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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Clonal analysis of CD4+/CD8+ T cells in a patient with aplastic anemia.</title><author><name sortKey="Moebius, U" sort="Moebius, U" uniqKey="Moebius U" first="U" last="Moebius">U. Moebius</name></author><author><name sortKey="Herrmann, F" sort="Herrmann, F" uniqKey="Herrmann F" first="F" last="Herrmann">F. Herrmann</name></author><author><name sortKey="Hercend, T" sort="Hercend, T" uniqKey="Hercend T" first="T" last="Hercend">T. Hercend</name></author><author><name sortKey="Meuer, S C" sort="Meuer, S C" uniqKey="Meuer S" first="S C" last="Meuer">S C Meuer</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">1827129</idno><idno type="pmc">295239</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC295239</idno><idno type="RBID">PMC:295239</idno><date when="1991">1991</date><idno type="wicri:Area/Pmc/Corpus">000164</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000164</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Clonal analysis of CD4+/CD8+ T cells in a patient with aplastic anemia.</title><author><name sortKey="Moebius, U" sort="Moebius, U" uniqKey="Moebius U" first="U" last="Moebius">U. Moebius</name></author><author><name sortKey="Herrmann, F" sort="Herrmann, F" uniqKey="Herrmann F" first="F" last="Herrmann">F. Herrmann</name></author><author><name sortKey="Hercend, T" sort="Hercend, T" uniqKey="Hercend T" first="T" last="Hercend">T. Hercend</name></author><author><name sortKey="Meuer, S C" sort="Meuer, S C" uniqKey="Meuer S" first="S C" last="Meuer">S C Meuer</name></author></analytic><series><title level="j">Journal of Clinical Investigation</title><idno type="ISSN">0021-9738</idno><imprint><date when="1991">1991</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>T cell clones were established from peripheral blood of a patient with severe aplastic anemia. 8 of 18 individual clonal T cell populations stably coexpressed CD4 and CD8 molecules, a phenotype characteristic for thymocytes and a minor subpopulation of circulating T lymphocytes. Analysis of T cell receptor genes revealed identical rearrangements of T cell receptor beta chain genes, suggesting clonality of these T cells. CD4+/CD8+ T cells clones were found to be efficiently cytotoxic towards autologous lymphoblasts. Autocytotoxicity could be blocked by a CD3 MAb, a MAb specific for monomorphic MHC class II determinants, and particularly, by an MHC-DP-specific MAb, suggesting specificity for autologous DP molecules. Perhaps more important, CD4+/CD8+ T cell clones inhibited differentiation of autologous progenitor enriched bone marrow cells in vitro by a direct cell-mediated mechanism. These data suggest that circulating cytotoxic CD4+/CD8+ T cell clones specific for autologous MHC-DP determinants may be involved in hematopoietic failure in some cases of aplastic anemia.</p><sec sec-type="scanned-figures"><title>Images</title><fig id="F1"><graphic xlink:href="jcinvest00059-0094-a" xlink:role="1570"></graphic></fig><fig id="F2"><graphic xlink:href="jcinvest00059-0094-b" xlink:role="1570"></graphic></fig></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Clin Invest</journal-id><journal-title>Journal of Clinical Investigation</journal-title><issn pub-type="ppub">0021-9738</issn></journal-meta><article-meta><article-id pub-id-type="pmid">1827129</article-id><article-id pub-id-type="pmc">295239</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title>Clonal analysis of CD4+/CD8+ T cells in a patient with aplastic anemia.</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Moebius</surname><given-names>U</given-names></name></contrib><contrib contrib-type="author"><name><surname>Herrmann</surname><given-names>F</given-names></name></contrib><contrib contrib-type="author"><name><surname>Hercend</surname><given-names>T</given-names></name></contrib><contrib contrib-type="author"><name><surname>Meuer</surname><given-names>S C</given-names></name></contrib></contrib-group><aff>Abteilung Angewandte Immunologie, Deutsches Krebsforschungszentrum, Heidelberg, FRG.</aff><pub-date pub-type="ppub"><month>5</month><year>1991</year></pub-date><volume>87</volume><issue>5</issue><fpage>1567</fpage><lpage>1574</lpage><abstract><p>T cell clones were established from peripheral blood of a patient with severe aplastic anemia. 8 of 18 individual clonal T cell populations stably coexpressed CD4 and CD8 molecules, a phenotype characteristic for thymocytes and a minor subpopulation of circulating T lymphocytes. Analysis of T cell receptor genes revealed identical rearrangements of T cell receptor beta chain genes, suggesting clonality of these T cells. CD4+/CD8+ T cells clones were found to be efficiently cytotoxic towards autologous lymphoblasts. Autocytotoxicity could be blocked by a CD3 MAb, a MAb specific for monomorphic MHC class II determinants, and particularly, by an MHC-DP-specific MAb, suggesting specificity for autologous DP molecules. Perhaps more important, CD4+/CD8+ T cell clones inhibited differentiation of autologous progenitor enriched bone marrow cells in vitro by a direct cell-mediated mechanism. These data suggest that circulating cytotoxic CD4+/CD8+ T cell clones specific for autologous MHC-DP determinants may be involved in hematopoietic failure in some cases of aplastic anemia.</p><sec sec-type="scanned-figures"><title>Images</title><fig id="F1"><graphic xlink:href="jcinvest00059-0094-a" xlink:role="1570"></graphic></fig><fig id="F2"><graphic xlink:href="jcinvest00059-0094-b" xlink:role="1570"></graphic></fig></sec></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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