Polymorphic Alu insertions and the genetic structure of Iberian Basques.
Identifieur interne : 000017 ( PubMed/Corpus ); précédent : 000016; suivant : 000018Polymorphic Alu insertions and the genetic structure of Iberian Basques.
Auteurs : S. García-Obreg N ; M A Alfonso-Sánchez ; A M Pérez-Miranda ; M M De Pancorbo ; J A Pe ASource :
- Journal of human genetics [ 1434-5161 ] ; 2007.
English descriptors
- KwdEn :
- MESH :
- geographic , ethnology : Spain.
- ethnology : European Continental Ancestry Group.
- genetics : Alu Elements, Ethnic Groups.
- Gene Frequency, Humans, Polymorphism, Genetic.
Abstract
Eight Alu sequences (ACE, TPA25, PV92, APO, FXIIIB, D1, A25 and B65) were analyzed in two samples from Navarre and Guipúzcoa provinces (Basque Country, Spain). Alu data for other European, Caucasus and North African populations were compiled from the literature for comparison purposes to assess the genetic relationships of the Basques in a broader geographic context. Results of both MDS plot and AMOVA revealed spatial heterogeneity among these three population clusters clearly defined by geography. On the contrary, no substantial genetic heterogeneity was found between the Basque samples, or between Basques and other Europeans (excluding Caucasus populations). Moreover, the genetic information obtained from Alu data conflicts with hypotheses linking the origin of Basques with populations from North Africa (Berbers) or from the Caucasus region (Georgia). In order to explain the reduced genetic heterogeneity detected by Alu insertions among Basque subpopulations, values of the Wright's F(ST )statistic were estimated for both Alu markers and a set of short tandem repeats (STRs) in terms of two geographical scales: (1) the Basque Country, (2) Europe (including Basques). In the Basque area, estimates of Wahlund's effect for both genetic markers showed no statistical difference between Basque subpopulations. However, when this analysis was performed on a European scale, F(ST) values were significantly higher for Alu insertions than for STR alleles. From these results, we suggest that the spatial heterogeneity of the Basque gene pool identified in previous polymorphism studies is relatively recent and probably caused by a differential process of genetic admixture with non-Basque neighboring populations modulated by the effect of a linguistic barrier to random mating.
DOI: 10.1007/s10038-007-0114-9
PubMed: 17277899
Links to Exploration step
pubmed:17277899Le document en format XML
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García-Obreg N</name><affiliation><nlm:affiliation>Departamento de Genética, Antropología Física y Fisiología Animal, Facultad de Ciencia y Tecnología, Universidad del País Vasco, Bilbao, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Alfonso Sanchez, M A" sort="Alfonso Sanchez, M A" uniqKey="Alfonso Sanchez M" first="M A" last="Alfonso-Sánchez">M A Alfonso-Sánchez</name></author><author><name sortKey="Perez Miranda, A M" sort="Perez Miranda, A M" uniqKey="Perez Miranda A" first="A M" last="Pérez-Miranda">A M Pérez-Miranda</name></author><author><name sortKey="De Pancorbo, M M" sort="De Pancorbo, M M" uniqKey="De Pancorbo M" first="M M" last="De Pancorbo">M M De Pancorbo</name></author><author><name sortKey="Pe A, J A" sort="Pe A, J A" uniqKey="Pe A J" first="J A" last="Pe A">J A Pe A</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2007">2007</date><idno type="RBID">pubmed:17277899</idno><idno type="pmid">17277899</idno><idno type="doi">10.1007/s10038-007-0114-9</idno><idno type="wicri:Area/PubMed/Corpus">000017</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000017</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Polymorphic Alu insertions and the genetic structure of Iberian Basques.</title><author><name sortKey="Garcia Obreg N, S" sort="Garcia Obreg N, S" uniqKey="Garcia Obreg N S" first="S" last="García-Obreg N">S. García-Obreg N</name><affiliation><nlm:affiliation>Departamento de Genética, Antropología Física y Fisiología Animal, Facultad de Ciencia y Tecnología, Universidad del País Vasco, Bilbao, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Alfonso Sanchez, M A" sort="Alfonso Sanchez, M A" uniqKey="Alfonso Sanchez M" first="M A" last="Alfonso-Sánchez">M A Alfonso-Sánchez</name></author><author><name sortKey="Perez Miranda, A M" sort="Perez Miranda, A M" uniqKey="Perez Miranda A" first="A M" last="Pérez-Miranda">A M Pérez-Miranda</name></author><author><name sortKey="De Pancorbo, M M" sort="De Pancorbo, M M" uniqKey="De Pancorbo M" first="M M" last="De Pancorbo">M M De Pancorbo</name></author><author><name sortKey="Pe A, J A" sort="Pe A, J A" uniqKey="Pe A J" first="J A" last="Pe A">J A Pe A</name></author></analytic><series><title level="j">Journal of human genetics</title><idno type="ISSN">1434-5161</idno><imprint><date when="2007" type="published">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alu Elements (genetics)</term><term>Ethnic Groups (genetics)</term><term>European Continental Ancestry Group (ethnology)</term><term>Gene Frequency</term><term>Humans</term><term>Polymorphism, Genetic</term><term>Spain (ethnology)</term></keywords><keywords scheme="MESH" type="geographic" qualifier="ethnology" xml:lang="en"><term>Spain</term></keywords><keywords scheme="MESH" qualifier="ethnology" xml:lang="en"><term>European Continental Ancestry Group</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Alu Elements</term><term>Ethnic Groups</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Gene Frequency</term><term>Humans</term><term>Polymorphism, Genetic</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Eight Alu sequences (ACE, TPA25, PV92, APO, FXIIIB, D1, A25 and B65) were analyzed in two samples from Navarre and Guipúzcoa provinces (Basque Country, Spain). Alu data for other European, Caucasus and North African populations were compiled from the literature for comparison purposes to assess the genetic relationships of the Basques in a broader geographic context. Results of both MDS plot and AMOVA revealed spatial heterogeneity among these three population clusters clearly defined by geography. On the contrary, no substantial genetic heterogeneity was found between the Basque samples, or between Basques and other Europeans (excluding Caucasus populations). Moreover, the genetic information obtained from Alu data conflicts with hypotheses linking the origin of Basques with populations from North Africa (Berbers) or from the Caucasus region (Georgia). In order to explain the reduced genetic heterogeneity detected by Alu insertions among Basque subpopulations, values of the Wright's F(ST )statistic were estimated for both Alu markers and a set of short tandem repeats (STRs) in terms of two geographical scales: (1) the Basque Country, (2) Europe (including Basques). In the Basque area, estimates of Wahlund's effect for both genetic markers showed no statistical difference between Basque subpopulations. However, when this analysis was performed on a European scale, F(ST) values were significantly higher for Alu insertions than for STR alleles. From these results, we suggest that the spatial heterogeneity of the Basque gene pool identified in previous polymorphism studies is relatively recent and probably caused by a differential process of genetic admixture with non-Basque neighboring populations modulated by the effect of a linguistic barrier to random mating.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">17277899</PMID><DateCreated><Year>2007</Year><Month>03</Month><Day>27</Day></DateCreated><DateCompleted><Year>2007</Year><Month>07</Month><Day>03</Day></DateCompleted><DateRevised><Year>2007</Year><Month>03</Month><Day>27</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">1434-5161</ISSN><JournalIssue CitedMedium="Print"><Volume>52</Volume><Issue>4</Issue><PubDate><Year>2007</Year></PubDate></JournalIssue><Title>Journal of human genetics</Title><ISOAbbreviation>J. Hum. Genet.</ISOAbbreviation></Journal><ArticleTitle>Polymorphic Alu insertions and the genetic structure of Iberian Basques.</ArticleTitle><Pagination><MedlinePgn>317-27</MedlinePgn></Pagination><Abstract><AbstractText>Eight Alu sequences (ACE, TPA25, PV92, APO, FXIIIB, D1, A25 and B65) were analyzed in two samples from Navarre and Guipúzcoa provinces (Basque Country, Spain). Alu data for other European, Caucasus and North African populations were compiled from the literature for comparison purposes to assess the genetic relationships of the Basques in a broader geographic context. Results of both MDS plot and AMOVA revealed spatial heterogeneity among these three population clusters clearly defined by geography. On the contrary, no substantial genetic heterogeneity was found between the Basque samples, or between Basques and other Europeans (excluding Caucasus populations). Moreover, the genetic information obtained from Alu data conflicts with hypotheses linking the origin of Basques with populations from North Africa (Berbers) or from the Caucasus region (Georgia). In order to explain the reduced genetic heterogeneity detected by Alu insertions among Basque subpopulations, values of the Wright's F(ST )statistic were estimated for both Alu markers and a set of short tandem repeats (STRs) in terms of two geographical scales: (1) the Basque Country, (2) Europe (including Basques). In the Basque area, estimates of Wahlund's effect for both genetic markers showed no statistical difference between Basque subpopulations. However, when this analysis was performed on a European scale, F(ST) values were significantly higher for Alu insertions than for STR alleles. From these results, we suggest that the spatial heterogeneity of the Basque gene pool identified in previous polymorphism studies is relatively recent and probably caused by a differential process of genetic admixture with non-Basque neighboring populations modulated by the effect of a linguistic barrier to random mating.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>García-Obregón</LastName><ForeName>S</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Departamento de Genética, Antropología Física y Fisiología Animal, Facultad de Ciencia y Tecnología, Universidad del País Vasco, Bilbao, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Alfonso-Sánchez</LastName><ForeName>M A</ForeName><Initials>MA</Initials></Author><Author ValidYN="Y"><LastName>Pérez-Miranda</LastName><ForeName>A M</ForeName><Initials>AM</Initials></Author><Author ValidYN="Y"><LastName>de Pancorbo</LastName><ForeName>M M</ForeName><Initials>MM</Initials></Author><Author ValidYN="Y"><LastName>Peña</LastName><ForeName>J A</ForeName><Initials>JA</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2007</Year><Month>02</Month><Day>03</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>J Hum Genet</MedlineTA><NlmUniqueID>9808008</NlmUniqueID><ISSNLinking>1434-5161</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D020087" MajorTopicYN="N">Alu Elements</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005006" MajorTopicYN="N">Ethnic Groups</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D044465" MajorTopicYN="N">European Continental Ancestry Group</DescriptorName><QualifierName UI="Q000208" MajorTopicYN="Y">ethnology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005787" MajorTopicYN="N">Gene Frequency</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011110" MajorTopicYN="Y">Polymorphism, Genetic</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013030" MajorTopicYN="N" Type="Geographic">Spain</DescriptorName><QualifierName UI="Q000208" MajorTopicYN="N">ethnology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2006</Year><Month>09</Month><Day>13</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2007</Year><Month>01</Month><Day>04</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2007</Year><Month>2</Month><Day>6</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2007</Year><Month>7</Month><Day>4</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2007</Year><Month>2</Month><Day>6</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">17277899</ArticleId><ArticleId IdType="doi">10.1007/s10038-007-0114-9</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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