Relatedness among Basques, Portuguese, Spaniards, and Algerians studied by HLA allelic frequencies and haplotypes.
Identifieur interne : 000030 ( PubMed/Checkpoint ); précédent : 000029; suivant : 000031Relatedness among Basques, Portuguese, Spaniards, and Algerians studied by HLA allelic frequencies and haplotypes.
Auteurs : A. Arnaiz-Villena [Espagne] ; J. Martínez-Laso ; E. G Mez-Casado ; N. Díaz-Campos ; P. Santos ; A. Martinho ; H. Breda-CoimbraSource :
- Immunogenetics [ 0093-7711 ] ; 1997.
Descripteurs français
- KwdFr :
- MESH :
- ethnologie : Espagne.
- génétique : Antigènes HLA, Groupes ethniques.
- Algérie, Allèles, Déséquilibre de liaison, Fréquence d'allèle, Haplotypes, Humains, Portugal, Émigration et immigration.
- Wicri :
- geographic : Espagne.
English descriptors
- KwdEn :
- MESH :
- chemical , genetics : HLA Antigens.
- geographic , ethnology : Spain.
- geographic : Algeria, Portugal.
- genetics : Ethnic Groups.
- Alleles, Emigration and Immigration, Gene Frequency, Haplotypes, Humans, Linkage Disequilibrium.
Abstract
HLA-A, -B, -DRB1, -DQA1, and DQB1 alleles were studied in Iberian and Algerian populations by serology and DNA sequence methodologies. The genetic and cultural relatedness among Basques, Spaniards, and paleo-North Africans (Berbers or Tamazights) was established. Portuguese people have also maintained a certain degree of cultural and ethnic-specific characteristics since ancient times. The results of the present HLA study in Portuguese populations show that they have features in common with Basques and Spaniards from Madrid: a high frequency of the HLA-haplotypes A29-B44-DR7 (ancient western Europeans), A2-B7-DR15 (ancient Europeans and paleo-North Africans), and A1-B8-DR3 (Europeans) are found as common characteristics. Portuguese and Basques do not show the Mediterranean A33-B14-DR1 haplotype, suggesting a lower admixture with Mediterraneans; Spaniards and Algerians do have this haplotype in a relatively high frequency, indicating a more extensive Mediterranean genetic influence. The paleo-North African haplotype A30-B18-DR3 present in Basques, Algerians, and Spaniards is not found in Portuguese either. The Portuguese have a characteristic unique among world populations: a high frequency of HLA-A25-B18-DR15 and A26-B38-DR13, which may reflect a still detectable founder effect coming from ancient Portuguese, i.e., oestrimnios and conios; Basques and Algerians also show specific haplotypes, A11-B27-DR1 and A2-B35-DR11, respectively, probably showing a relatively lower degree of admixture. A neighbor-joining dendrogram place Basques, Portuguese, Spaniards, and Algerians closer to each other and more separated from other populations. Genetic, cultural, geological, and linguistic evidence also supports the hypothesis that people coming from a fertile Saharan area emigrated towards the north (southern Europe, Mesopotamia, the Mediterranean Islands, and the North African coast) when the climate changed drastically to hotter and drier ca 10 000 years B.C.
PubMed: 9382919
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Arnaiz-Villena</name><affiliation wicri:level="3"><nlm:affiliation>Department of Immunology, Hospital 12 de Octubre, Universidad Complutense, Avda. Andalucía s/n. E-28041, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Immunology, Hospital 12 de Octubre, Universidad Complutense, Avda. Andalucía s/n. E-28041, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Martinez Laso, J" sort="Martinez Laso, J" uniqKey="Martinez Laso J" first="J" last="Martínez-Laso">J. Martínez-Laso</name></author><author><name sortKey="G Mez Casado, E" sort="G Mez Casado, E" uniqKey="G Mez Casado E" first="E" last="G Mez-Casado">E. G Mez-Casado</name></author><author><name sortKey="Diaz Campos, N" sort="Diaz Campos, N" uniqKey="Diaz Campos N" first="N" last="Díaz-Campos">N. Díaz-Campos</name></author><author><name sortKey="Santos, P" sort="Santos, P" uniqKey="Santos P" first="P" last="Santos">P. Santos</name></author><author><name sortKey="Martinho, A" sort="Martinho, A" uniqKey="Martinho A" first="A" last="Martinho">A. Martinho</name></author><author><name sortKey="Breda Coimbra, H" sort="Breda Coimbra, H" uniqKey="Breda Coimbra H" first="H" last="Breda-Coimbra">H. Breda-Coimbra</name></author></analytic><series><title level="j">Immunogenetics</title><idno type="ISSN">0093-7711</idno><imprint><date when="1997" type="published">1997</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Algeria</term><term>Alleles</term><term>Emigration and Immigration</term><term>Ethnic Groups (genetics)</term><term>Gene Frequency</term><term>HLA Antigens (genetics)</term><term>Haplotypes</term><term>Humans</term><term>Linkage Disequilibrium</term><term>Portugal</term><term>Spain (ethnology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Algérie</term><term>Allèles</term><term>Antigènes HLA (génétique)</term><term>Déséquilibre de liaison</term><term>Espagne (ethnologie)</term><term>Fréquence d'allèle</term><term>Groupes ethniques (génétique)</term><term>Haplotypes</term><term>Humains</term><term>Portugal</term><term>Émigration et immigration</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>HLA Antigens</term></keywords><keywords scheme="MESH" type="geographic" qualifier="ethnology" xml:lang="en"><term>Spain</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Algeria</term><term>Portugal</term></keywords><keywords scheme="MESH" qualifier="ethnologie" xml:lang="fr"><term>Espagne</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Ethnic Groups</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Antigènes HLA</term><term>Groupes ethniques</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Alleles</term><term>Emigration and Immigration</term><term>Gene Frequency</term><term>Haplotypes</term><term>Humans</term><term>Linkage Disequilibrium</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Algérie</term><term>Allèles</term><term>Déséquilibre de liaison</term><term>Fréquence d'allèle</term><term>Haplotypes</term><term>Humains</term><term>Portugal</term><term>Émigration et immigration</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Espagne</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">HLA-A, -B, -DRB1, -DQA1, and DQB1 alleles were studied in Iberian and Algerian populations by serology and DNA sequence methodologies. The genetic and cultural relatedness among Basques, Spaniards, and paleo-North Africans (Berbers or Tamazights) was established. Portuguese people have also maintained a certain degree of cultural and ethnic-specific characteristics since ancient times. The results of the present HLA study in Portuguese populations show that they have features in common with Basques and Spaniards from Madrid: a high frequency of the HLA-haplotypes A29-B44-DR7 (ancient western Europeans), A2-B7-DR15 (ancient Europeans and paleo-North Africans), and A1-B8-DR3 (Europeans) are found as common characteristics. Portuguese and Basques do not show the Mediterranean A33-B14-DR1 haplotype, suggesting a lower admixture with Mediterraneans; Spaniards and Algerians do have this haplotype in a relatively high frequency, indicating a more extensive Mediterranean genetic influence. The paleo-North African haplotype A30-B18-DR3 present in Basques, Algerians, and Spaniards is not found in Portuguese either. The Portuguese have a characteristic unique among world populations: a high frequency of HLA-A25-B18-DR15 and A26-B38-DR13, which may reflect a still detectable founder effect coming from ancient Portuguese, i.e., oestrimnios and conios; Basques and Algerians also show specific haplotypes, A11-B27-DR1 and A2-B35-DR11, respectively, probably showing a relatively lower degree of admixture. A neighbor-joining dendrogram place Basques, Portuguese, Spaniards, and Algerians closer to each other and more separated from other populations. Genetic, cultural, geological, and linguistic evidence also supports the hypothesis that people coming from a fertile Saharan area emigrated towards the north (southern Europe, Mesopotamia, the Mediterranean Islands, and the North African coast) when the climate changed drastically to hotter and drier ca 10 000 years B.C.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">9382919</PMID><DateCreated><Year>1998</Year><Month>01</Month><Day>15</Day></DateCreated><DateCompleted><Year>1998</Year><Month>01</Month><Day>15</Day></DateCompleted><DateRevised><Year>2006</Year><Month>11</Month><Day>15</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0093-7711</ISSN><JournalIssue CitedMedium="Print"><Volume>47</Volume><Issue>1</Issue><PubDate><Year>1997</Year></PubDate></JournalIssue><Title>Immunogenetics</Title><ISOAbbreviation>Immunogenetics</ISOAbbreviation></Journal><ArticleTitle>Relatedness among Basques, Portuguese, Spaniards, and Algerians studied by HLA allelic frequencies and haplotypes.</ArticleTitle><Pagination><MedlinePgn>37-43</MedlinePgn></Pagination><Abstract><AbstractText>HLA-A, -B, -DRB1, -DQA1, and DQB1 alleles were studied in Iberian and Algerian populations by serology and DNA sequence methodologies. The genetic and cultural relatedness among Basques, Spaniards, and paleo-North Africans (Berbers or Tamazights) was established. Portuguese people have also maintained a certain degree of cultural and ethnic-specific characteristics since ancient times. The results of the present HLA study in Portuguese populations show that they have features in common with Basques and Spaniards from Madrid: a high frequency of the HLA-haplotypes A29-B44-DR7 (ancient western Europeans), A2-B7-DR15 (ancient Europeans and paleo-North Africans), and A1-B8-DR3 (Europeans) are found as common characteristics. Portuguese and Basques do not show the Mediterranean A33-B14-DR1 haplotype, suggesting a lower admixture with Mediterraneans; Spaniards and Algerians do have this haplotype in a relatively high frequency, indicating a more extensive Mediterranean genetic influence. The paleo-North African haplotype A30-B18-DR3 present in Basques, Algerians, and Spaniards is not found in Portuguese either. The Portuguese have a characteristic unique among world populations: a high frequency of HLA-A25-B18-DR15 and A26-B38-DR13, which may reflect a still detectable founder effect coming from ancient Portuguese, i.e., oestrimnios and conios; Basques and Algerians also show specific haplotypes, A11-B27-DR1 and A2-B35-DR11, respectively, probably showing a relatively lower degree of admixture. A neighbor-joining dendrogram place Basques, Portuguese, Spaniards, and Algerians closer to each other and more separated from other populations. Genetic, cultural, geological, and linguistic evidence also supports the hypothesis that people coming from a fertile Saharan area emigrated towards the north (southern Europe, Mesopotamia, the Mediterranean Islands, and the North African coast) when the climate changed drastically to hotter and drier ca 10 000 years B.C.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Arnaiz-Villena</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Immunology, Hospital 12 de Octubre, Universidad Complutense, Avda. Andalucía s/n. E-28041, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Martínez-Laso</LastName><ForeName>J</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Gómez-Casado</LastName><ForeName>E</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Díaz-Campos</LastName><ForeName>N</ForeName><Initials>N</Initials></Author><Author ValidYN="Y"><LastName>Santos</LastName><ForeName>P</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Martinho</LastName><ForeName>A</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Breda-Coimbra</LastName><ForeName>H</ForeName><Initials>H</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Immunogenetics</MedlineTA><NlmUniqueID>0420404</NlmUniqueID><ISSNLinking>0093-7711</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D006680">HLA Antigens</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000462" MajorTopicYN="N" Type="Geographic">Algeria</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000483" MajorTopicYN="N">Alleles</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004641" MajorTopicYN="N">Emigration and Immigration</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005006" MajorTopicYN="N">Ethnic Groups</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005787" MajorTopicYN="N">Gene Frequency</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006680" MajorTopicYN="N">HLA Antigens</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006239" MajorTopicYN="N">Haplotypes</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015810" MajorTopicYN="N">Linkage Disequilibrium</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011174" MajorTopicYN="N" Type="Geographic">Portugal</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013030" MajorTopicYN="N" Type="Geographic">Spain</DescriptorName><QualifierName UI="Q000208" MajorTopicYN="N">ethnology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1997</Year><Month>1</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1998</Year><Month>2</Month><Day>12</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1997</Year><Month>1</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">9382919</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Espagne</li></country><region><li>Communauté de Madrid</li></region><settlement><li>Madrid</li></settlement></list><tree><noCountry><name sortKey="Breda Coimbra, H" sort="Breda Coimbra, H" uniqKey="Breda Coimbra H" first="H" last="Breda-Coimbra">H. Breda-Coimbra</name><name sortKey="Diaz Campos, N" sort="Diaz Campos, N" uniqKey="Diaz Campos N" first="N" last="Díaz-Campos">N. Díaz-Campos</name><name sortKey="G Mez Casado, E" sort="G Mez Casado, E" uniqKey="G Mez Casado E" first="E" last="G Mez-Casado">E. G Mez-Casado</name><name sortKey="Martinez Laso, J" sort="Martinez Laso, J" uniqKey="Martinez Laso J" first="J" last="Martínez-Laso">J. Martínez-Laso</name><name sortKey="Martinho, A" sort="Martinho, A" uniqKey="Martinho A" first="A" last="Martinho">A. Martinho</name><name sortKey="Santos, P" sort="Santos, P" uniqKey="Santos P" first="P" last="Santos">P. Santos</name></noCountry><country name="Espagne"><region name="Communauté de Madrid"><name sortKey="Arnaiz Villena, A" sort="Arnaiz Villena, A" uniqKey="Arnaiz Villena A" first="A" last="Arnaiz-Villena">A. Arnaiz-Villena</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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