The origin of Cretan populations as determined by characterization of HLA alleles.
Identifieur interne : 000029 ( PubMed/Checkpoint ); précédent : 000028; suivant : 000030The origin of Cretan populations as determined by characterization of HLA alleles.
Auteurs : A. Arnaiz-Villena [Espagne] ; P. Iliakis ; M. González-Hevilla ; J. Longás ; E. G Mez-Casado ; K. Sfyridaki ; J. Trapaga ; C. Silvera-Redondo ; C. Matsouka ; J. Martínez-LasoSource :
- Tissue antigens [ 0001-2815 ] ; 1999.
Descripteurs français
- KwdFr :
- Allèles, Antigènes HLA (génétique), Antigènes HLA-A (génétique), Antigènes HLA-B (génétique), Antigènes HLA-DQ (génétique), Antigènes HLA-DR (génétique), Chaines HLA-DRB1, Chaines bêta des antigènes HLA-DQ, Fréquence d'allèle, Grèce, Génotype, Humains, Émigration et immigration, Évolution moléculaire.
- MESH :
- Wicri :
- geographic : Grèce.
English descriptors
- KwdEn :
- MESH :
- chemical , genetics : HLA Antigens, HLA-A Antigens, HLA-B Antigens, HLA-DQ Antigens, HLA-DR Antigens.
- geographic : Greece, HLA-DQ beta-Chains, HLA-DRB1 Chains.
- Alleles, Emigration and Immigration, Evolution, Molecular, Gene Frequency, Genotype, Humans.
Abstract
The Cretan HLA gene profile has been compared with those of other Mediterranean populations in order to provide additional information regarding the history of their origins. The allele frequencies, genetic distances between populations, relatedness dendrograms and correspondence analyses were calculated. Our results indicate that the Indoeuropean Greeks may be considered as a Mediterranean population of a more recent origin (after 2000 B.C.), while all other studied Mediterraneans (including Cretans) belong to an older substratum which was present in the area since pre-Neolithic times. A significant Turkish gene flow has not been detected in the Greek or Cretan populations, although Greeks and Turks have two high frequency HLA-DRB-DQB haplotypes in common. It is proposed that Imazighen (Caucasoid Berbers living at present in the North African coast and Saharan areas) are the remains of pre-Neolithic Saharan populations which could emigrate northwards between about 8000-6000 B.C., when desert desiccation began. They also could be part of the stock that gave rise to Sumerians, Cretans and Iberians; this is supported by both linguistic and HLA genetic data.
PubMed: 10203014
Affiliations:
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Arnaiz-Villena</name><affiliation wicri:level="3"><nlm:affiliation>Department of Immunology and Molecular Biology, H. 12 de Octubre, Universidad Complutense, Madrid, Spain. Antonio.Arnaiz@inm.h12o.es</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Immunology and Molecular Biology, H. 12 de Octubre, Universidad Complutense, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Iliakis, P" sort="Iliakis, P" uniqKey="Iliakis P" first="P" last="Iliakis">P. Iliakis</name></author><author><name sortKey="Gonzalez Hevilla, M" sort="Gonzalez Hevilla, M" uniqKey="Gonzalez Hevilla M" first="M" last="González-Hevilla">M. González-Hevilla</name></author><author><name sortKey="Longas, J" sort="Longas, J" uniqKey="Longas J" first="J" last="Longás">J. Longás</name></author><author><name sortKey="G Mez Casado, E" sort="G Mez Casado, E" uniqKey="G Mez Casado E" first="E" last="G Mez-Casado">E. G Mez-Casado</name></author><author><name sortKey="Sfyridaki, K" sort="Sfyridaki, K" uniqKey="Sfyridaki K" first="K" last="Sfyridaki">K. Sfyridaki</name></author><author><name sortKey="Trapaga, J" sort="Trapaga, J" uniqKey="Trapaga J" first="J" last="Trapaga">J. Trapaga</name></author><author><name sortKey="Silvera Redondo, C" sort="Silvera Redondo, C" uniqKey="Silvera Redondo C" first="C" last="Silvera-Redondo">C. Silvera-Redondo</name></author><author><name sortKey="Matsouka, C" sort="Matsouka, C" uniqKey="Matsouka C" first="C" last="Matsouka">C. Matsouka</name></author><author><name sortKey="Martinez Laso, J" sort="Martinez Laso, J" uniqKey="Martinez Laso J" first="J" last="Martínez-Laso">J. Martínez-Laso</name></author></analytic><series><title level="j">Tissue antigens</title><idno type="ISSN">0001-2815</idno><imprint><date when="1999" type="published">1999</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alleles</term><term>Emigration and Immigration</term><term>Evolution, Molecular</term><term>Gene Frequency</term><term>Genotype</term><term>Greece</term><term>HLA Antigens (genetics)</term><term>HLA-A Antigens (genetics)</term><term>HLA-B Antigens (genetics)</term><term>HLA-DQ Antigens (genetics)</term><term>HLA-DQ beta-Chains</term><term>HLA-DR Antigens (genetics)</term><term>HLA-DRB1 Chains</term><term>Humans</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Allèles</term><term>Antigènes HLA (génétique)</term><term>Antigènes HLA-A (génétique)</term><term>Antigènes HLA-B (génétique)</term><term>Antigènes HLA-DQ (génétique)</term><term>Antigènes HLA-DR (génétique)</term><term>Chaines HLA-DRB1</term><term>Chaines bêta des antigènes HLA-DQ</term><term>Fréquence d'allèle</term><term>Grèce</term><term>Génotype</term><term>Humains</term><term>Émigration et immigration</term><term>Évolution moléculaire</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>HLA Antigens</term><term>HLA-A Antigens</term><term>HLA-B Antigens</term><term>HLA-DQ Antigens</term><term>HLA-DR Antigens</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Greece</term><term>HLA-DQ beta-Chains</term><term>HLA-DRB1 Chains</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Antigènes HLA</term><term>Antigènes HLA-A</term><term>Antigènes HLA-B</term><term>Antigènes HLA-DQ</term><term>Antigènes HLA-DR</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Alleles</term><term>Emigration and Immigration</term><term>Evolution, Molecular</term><term>Gene Frequency</term><term>Genotype</term><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Allèles</term><term>Chaines HLA-DRB1</term><term>Chaines bêta des antigènes HLA-DQ</term><term>Fréquence d'allèle</term><term>Grèce</term><term>Génotype</term><term>Humains</term><term>Émigration et immigration</term><term>Évolution moléculaire</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Grèce</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The Cretan HLA gene profile has been compared with those of other Mediterranean populations in order to provide additional information regarding the history of their origins. The allele frequencies, genetic distances between populations, relatedness dendrograms and correspondence analyses were calculated. Our results indicate that the Indoeuropean Greeks may be considered as a Mediterranean population of a more recent origin (after 2000 B.C.), while all other studied Mediterraneans (including Cretans) belong to an older substratum which was present in the area since pre-Neolithic times. A significant Turkish gene flow has not been detected in the Greek or Cretan populations, although Greeks and Turks have two high frequency HLA-DRB-DQB haplotypes in common. It is proposed that Imazighen (Caucasoid Berbers living at present in the North African coast and Saharan areas) are the remains of pre-Neolithic Saharan populations which could emigrate northwards between about 8000-6000 B.C., when desert desiccation began. They also could be part of the stock that gave rise to Sumerians, Cretans and Iberians; this is supported by both linguistic and HLA genetic data.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">10203014</PMID><DateCreated><Year>1999</Year><Month>06</Month><Day>01</Day></DateCreated><DateCompleted><Year>1999</Year><Month>06</Month><Day>01</Day></DateCompleted><DateRevised><Year>2011</Year><Month>11</Month><Day>17</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0001-2815</ISSN><JournalIssue CitedMedium="Print"><Volume>53</Volume><Issue>3</Issue><PubDate><Year>1999</Year><Month>Mar</Month></PubDate></JournalIssue><Title>Tissue antigens</Title><ISOAbbreviation>Tissue Antigens</ISOAbbreviation></Journal><ArticleTitle>The origin of Cretan populations as determined by characterization of HLA alleles.</ArticleTitle><Pagination><MedlinePgn>213-26</MedlinePgn></Pagination><Abstract><AbstractText>The Cretan HLA gene profile has been compared with those of other Mediterranean populations in order to provide additional information regarding the history of their origins. The allele frequencies, genetic distances between populations, relatedness dendrograms and correspondence analyses were calculated. Our results indicate that the Indoeuropean Greeks may be considered as a Mediterranean population of a more recent origin (after 2000 B.C.), while all other studied Mediterraneans (including Cretans) belong to an older substratum which was present in the area since pre-Neolithic times. A significant Turkish gene flow has not been detected in the Greek or Cretan populations, although Greeks and Turks have two high frequency HLA-DRB-DQB haplotypes in common. It is proposed that Imazighen (Caucasoid Berbers living at present in the North African coast and Saharan areas) are the remains of pre-Neolithic Saharan populations which could emigrate northwards between about 8000-6000 B.C., when desert desiccation began. They also could be part of the stock that gave rise to Sumerians, Cretans and Iberians; this is supported by both linguistic and HLA genetic data.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Arnaiz-Villena</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Immunology and Molecular Biology, H. 12 de Octubre, Universidad Complutense, Madrid, Spain. Antonio.Arnaiz@inm.h12o.es</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Iliakis</LastName><ForeName>P</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>González-Hevilla</LastName><ForeName>M</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Longás</LastName><ForeName>J</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Gómez-Casado</LastName><ForeName>E</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Sfyridaki</LastName><ForeName>K</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Trapaga</LastName><ForeName>J</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Silvera-Redondo</LastName><ForeName>C</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Matsouka</LastName><ForeName>C</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Martínez-Laso</LastName><ForeName>J</ForeName><Initials>J</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Tissue Antigens</MedlineTA><NlmUniqueID>0331072</NlmUniqueID><ISSNLinking>0001-2815</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D006680">HLA Antigens</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015234">HLA-A Antigens</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015235">HLA-B Antigens</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D006683">HLA-DQ Antigens</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D059866">HLA-DQ beta-Chains</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C069051">HLA-DQB1 antigen</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D006684">HLA-DR Antigens</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D059811">HLA-DRB1 Chains</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000483" MajorTopicYN="N">Alleles</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004641" MajorTopicYN="N">Emigration and Immigration</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019143" MajorTopicYN="Y">Evolution, Molecular</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005787" MajorTopicYN="N">Gene Frequency</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005838" MajorTopicYN="N">Genotype</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006115" MajorTopicYN="N" Type="Geographic">Greece</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006680" MajorTopicYN="N">HLA Antigens</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015234" MajorTopicYN="N">HLA-A Antigens</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015235" MajorTopicYN="N">HLA-B Antigens</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006683" MajorTopicYN="N">HLA-DQ Antigens</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D059866" MajorTopicYN="N">HLA-DQ beta-Chains</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006684" MajorTopicYN="N">HLA-DR Antigens</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D059811" MajorTopicYN="N">HLA-DRB1 Chains</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1999</Year><Month>4</Month><Day>15</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1999</Year><Month>4</Month><Day>15</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1999</Year><Month>4</Month><Day>15</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">10203014</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Espagne</li></country><region><li>Communauté de Madrid</li></region><settlement><li>Madrid</li></settlement></list><tree><noCountry><name sortKey="G Mez Casado, E" sort="G Mez Casado, E" uniqKey="G Mez Casado E" first="E" last="G Mez-Casado">E. G Mez-Casado</name><name sortKey="Gonzalez Hevilla, M" sort="Gonzalez Hevilla, M" uniqKey="Gonzalez Hevilla M" first="M" last="González-Hevilla">M. González-Hevilla</name><name sortKey="Iliakis, P" sort="Iliakis, P" uniqKey="Iliakis P" first="P" last="Iliakis">P. Iliakis</name><name sortKey="Longas, J" sort="Longas, J" uniqKey="Longas J" first="J" last="Longás">J. Longás</name><name sortKey="Martinez Laso, J" sort="Martinez Laso, J" uniqKey="Martinez Laso J" first="J" last="Martínez-Laso">J. Martínez-Laso</name><name sortKey="Matsouka, C" sort="Matsouka, C" uniqKey="Matsouka C" first="C" last="Matsouka">C. Matsouka</name><name sortKey="Sfyridaki, K" sort="Sfyridaki, K" uniqKey="Sfyridaki K" first="K" last="Sfyridaki">K. Sfyridaki</name><name sortKey="Silvera Redondo, C" sort="Silvera Redondo, C" uniqKey="Silvera Redondo C" first="C" last="Silvera-Redondo">C. Silvera-Redondo</name><name sortKey="Trapaga, J" sort="Trapaga, J" uniqKey="Trapaga J" first="J" last="Trapaga">J. Trapaga</name></noCountry><country name="Espagne"><region name="Communauté de Madrid"><name sortKey="Arnaiz Villena, A" sort="Arnaiz Villena, A" uniqKey="Arnaiz Villena A" first="A" last="Arnaiz-Villena">A. Arnaiz-Villena</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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