Genetic structure of north-west Africa revealed by STR analysis.
Identifieur interne : 000003 ( Ncbi/Checkpoint ); précédent : 000002; suivant : 000004Genetic structure of north-west Africa revealed by STR analysis.
Auteurs : E. Bosch [Espagne] ; F. Calafell ; A. Pérez-Lezaun ; J. Clarim N ; D. Comas ; E. Mateu ; R. Martínez-Arias ; B. Morera ; Z. Brakez ; O. Akhayat ; A. Sefiani ; G. Hariti ; A. Cambon-Thomsen ; J. BertranpetitSource :
- European journal of human genetics : EJHG [ 1018-4813 ] ; 2000.
Descripteurs français
- KwdFr :
- MESH :
- ethnologie : Afrique du Nord.
- génétique : Arabes, Répétitions microsatellites, Séquences répétées en tandem.
- Génétique des populations, Humains, Hétérogénéité génétique.
English descriptors
- KwdEn :
- MESH :
- geographic , ethnology : Africa, Northern.
- genetics : Arabs, Microsatellite Repeats, Tandem Repeat Sequences.
- Genetic Heterogeneity, Genetics, Population, Humans.
Abstract
We have analysed a large set of autosomal short tandem repeat (STR) loci in several Arabic and Berber-speaking groups from north-west Africa (ie Moroccan Arabs, northern-central and southern Moroccan Berbers, Saharawis, and Mozabites). Two levels of analysis have been devised using two sets of 12STR loci, (D3S1358, vWA, FGA, THO1, TPOX, CSF1PO, D8S1179, D21S11, D18S51, D5S818, D13S317 and D7S820) and 21 (the former set plus D9S926, D11S2010, D13S767, D14S306, D18S848, D2S1328, D4S243, F13A1, and FES/FPS). For each set, data for a number of external reference populations were gathered from the literature. Several methods of analysis based on genetic distances (neighbour-joining trees, principal coordinate analysis, boundary detection), as well as AMOVA, showed that genetic differentiation among NW African populations was very low and devoid of any spatial pattern. When the NW African populations were grouped according to cultural or linguistic differences, the partition was not associated with genetic differentiation. Thus, it is likely that Arabisation was mainly a cultural process. A clear genetic difference was found between NW African populations and Iberians, which underscores the Gilbraltar Straits as a strong barrier to genetic exchange; nonetheless, some degree of gene flow into Southern Iberia may have existed. NW Africans were genetically closer to Iberians and to other Europeans than to African Americans.
DOI: 10.1038/sj.ejhg.5200464
PubMed: 10854096
Affiliations:
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Bosch</name><affiliation wicri:level="4"><nlm:affiliation>Unitat de Biologia Evolutiva, Facultat de Ciències de la Salut i de la Vida, Universitat Pompeu Fabra, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Unitat de Biologia Evolutiva, Facultat de Ciències de la Salut i de la Vida, Universitat Pompeu Fabra, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName><orgName type="university">Université Pompeu Fabra</orgName></affiliation></author><author><name sortKey="Calafell, F" sort="Calafell, F" uniqKey="Calafell F" first="F" last="Calafell">F. Calafell</name></author><author><name sortKey="Perez Lezaun, A" sort="Perez Lezaun, A" uniqKey="Perez Lezaun A" first="A" last="Pérez-Lezaun">A. Pérez-Lezaun</name></author><author><name sortKey="Clarim N, J" sort="Clarim N, J" uniqKey="Clarim N J" first="J" last="Clarim N">J. Clarim N</name></author><author><name sortKey="Comas, D" sort="Comas, D" uniqKey="Comas D" first="D" last="Comas">D. Comas</name></author><author><name sortKey="Mateu, E" sort="Mateu, E" uniqKey="Mateu E" first="E" last="Mateu">E. Mateu</name></author><author><name sortKey="Martinez Arias, R" sort="Martinez Arias, R" uniqKey="Martinez Arias R" first="R" last="Martínez-Arias">R. Martínez-Arias</name></author><author><name sortKey="Morera, B" sort="Morera, B" uniqKey="Morera B" first="B" last="Morera">B. Morera</name></author><author><name sortKey="Brakez, Z" sort="Brakez, Z" uniqKey="Brakez Z" first="Z" last="Brakez">Z. Brakez</name></author><author><name sortKey="Akhayat, O" sort="Akhayat, O" uniqKey="Akhayat O" first="O" last="Akhayat">O. Akhayat</name></author><author><name sortKey="Sefiani, A" sort="Sefiani, A" uniqKey="Sefiani A" first="A" last="Sefiani">A. Sefiani</name></author><author><name sortKey="Hariti, G" sort="Hariti, G" uniqKey="Hariti G" first="G" last="Hariti">G. Hariti</name></author><author><name sortKey="Cambon Thomsen, A" sort="Cambon Thomsen, A" uniqKey="Cambon Thomsen A" first="A" last="Cambon-Thomsen">A. Cambon-Thomsen</name></author><author><name sortKey="Bertranpetit, J" sort="Bertranpetit, J" uniqKey="Bertranpetit J" first="J" last="Bertranpetit">J. Bertranpetit</name></author></analytic><series><title level="j">European journal of human genetics : EJHG</title><idno type="ISSN">1018-4813</idno><imprint><date when="2000" type="published">2000</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Africa, Northern (ethnology)</term><term>Arabs (genetics)</term><term>Genetic Heterogeneity</term><term>Genetics, Population</term><term>Humans</term><term>Microsatellite Repeats (genetics)</term><term>Tandem Repeat Sequences (genetics)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Afrique du Nord (ethnologie)</term><term>Arabes (génétique)</term><term>Génétique des populations</term><term>Humains</term><term>Hétérogénéité génétique</term><term>Répétitions microsatellites (génétique)</term><term>Séquences répétées en tandem (génétique)</term></keywords><keywords scheme="MESH" type="geographic" qualifier="ethnology" xml:lang="en"><term>Africa, Northern</term></keywords><keywords scheme="MESH" qualifier="ethnologie" xml:lang="fr"><term>Afrique du Nord</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Arabs</term><term>Microsatellite Repeats</term><term>Tandem Repeat Sequences</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Arabes</term><term>Répétitions microsatellites</term><term>Séquences répétées en tandem</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Genetic Heterogeneity</term><term>Genetics, Population</term><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Génétique des populations</term><term>Humains</term><term>Hétérogénéité génétique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We have analysed a large set of autosomal short tandem repeat (STR) loci in several Arabic and Berber-speaking groups from north-west Africa (ie Moroccan Arabs, northern-central and southern Moroccan Berbers, Saharawis, and Mozabites). Two levels of analysis have been devised using two sets of 12STR loci, (D3S1358, vWA, FGA, THO1, TPOX, CSF1PO, D8S1179, D21S11, D18S51, D5S818, D13S317 and D7S820) and 21 (the former set plus D9S926, D11S2010, D13S767, D14S306, D18S848, D2S1328, D4S243, F13A1, and FES/FPS). For each set, data for a number of external reference populations were gathered from the literature. Several methods of analysis based on genetic distances (neighbour-joining trees, principal coordinate analysis, boundary detection), as well as AMOVA, showed that genetic differentiation among NW African populations was very low and devoid of any spatial pattern. When the NW African populations were grouped according to cultural or linguistic differences, the partition was not associated with genetic differentiation. Thus, it is likely that Arabisation was mainly a cultural process. A clear genetic difference was found between NW African populations and Iberians, which underscores the Gilbraltar Straits as a strong barrier to genetic exchange; nonetheless, some degree of gene flow into Southern Iberia may have existed. NW Africans were genetically closer to Iberians and to other Europeans than to African Americans.</div></front></TEI><affiliations><list><country><li>Espagne</li></country><region><li>Catalogne</li></region><settlement><li>Barcelone</li></settlement><orgName><li>Université Pompeu Fabra</li></orgName></list><tree><noCountry><name sortKey="Akhayat, O" sort="Akhayat, O" uniqKey="Akhayat O" first="O" last="Akhayat">O. Akhayat</name><name sortKey="Bertranpetit, J" sort="Bertranpetit, J" uniqKey="Bertranpetit J" first="J" last="Bertranpetit">J. Bertranpetit</name><name sortKey="Brakez, Z" sort="Brakez, Z" uniqKey="Brakez Z" first="Z" last="Brakez">Z. Brakez</name><name sortKey="Calafell, F" sort="Calafell, F" uniqKey="Calafell F" first="F" last="Calafell">F. Calafell</name><name sortKey="Cambon Thomsen, A" sort="Cambon Thomsen, A" uniqKey="Cambon Thomsen A" first="A" last="Cambon-Thomsen">A. Cambon-Thomsen</name><name sortKey="Clarim N, J" sort="Clarim N, J" uniqKey="Clarim N J" first="J" last="Clarim N">J. Clarim N</name><name sortKey="Comas, D" sort="Comas, D" uniqKey="Comas D" first="D" last="Comas">D. Comas</name><name sortKey="Hariti, G" sort="Hariti, G" uniqKey="Hariti G" first="G" last="Hariti">G. Hariti</name><name sortKey="Martinez Arias, R" sort="Martinez Arias, R" uniqKey="Martinez Arias R" first="R" last="Martínez-Arias">R. Martínez-Arias</name><name sortKey="Mateu, E" sort="Mateu, E" uniqKey="Mateu E" first="E" last="Mateu">E. Mateu</name><name sortKey="Morera, B" sort="Morera, B" uniqKey="Morera B" first="B" last="Morera">B. Morera</name><name sortKey="Perez Lezaun, A" sort="Perez Lezaun, A" uniqKey="Perez Lezaun A" first="A" last="Pérez-Lezaun">A. Pérez-Lezaun</name><name sortKey="Sefiani, A" sort="Sefiani, A" uniqKey="Sefiani A" first="A" last="Sefiani">A. Sefiani</name></noCountry><country name="Espagne"><region name="Catalogne"><name sortKey="Bosch, E" sort="Bosch, E" uniqKey="Bosch E" first="E" last="Bosch">E. Bosch</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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