Living near agricultural pesticide applications and the risk of adverse reproductive outcomes: a review of the literature
Identifieur interne : 000E31 ( Istex/Corpus ); précédent : 000E30; suivant : 000E32Living near agricultural pesticide applications and the risk of adverse reproductive outcomes: a review of the literature
Auteurs : Adeleh Shirangi ; Mark Nieuwenhuijsen ; Danielle Vienneau ; C. D'Arcy J. HolmanSource :
- Paediatric and Perinatal Epidemiology [ 0269-5022 ] ; 2011-03.
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Abstract
Shirangi A, Nieuwenhuijsen M, Vienneau D, Holman CDJ. Living near agricultural pesticide applications and the risk of adverse reproductive outcomes: a review of the literature. Paediatric and Perinatal Epidemiology 2010. Over the last decade, there has been growing concern about the possible health effects, including a number of adverse reproductive outcomes, from pesticide exposure of people living near agricultural fields. This systematic review evaluates the current epidemiological evidence on the association between living near agricultural pesticide applications and adverse reproductive outcomes, including congenital malformations, stillbirth, intrauterine growth retardation (IUGR), low birthweight, preterm birth and miscarriage. We identified and reviewed 25 studies from a systematic search of the main scientific databases and other sources published in 1950–2007. Study methods and main results were summarised and tabulated according to the year of study, design and type of adverse reproductive outcome. The levels of evidence for reproductive toxicity in humans contributed by each study were assessed and the main limitations associated with these studies discussed. Residential proximity to agricultural pesticide applications may be an important source of ambient environmental exposure, but because of the underlying methodological difficulties, the strength of evidence for its relationship with adverse reproductive outcomes is generally weak and varied between outcomes. The evidence suggested an association for congenital malformations, but because of methodological limitations, such as poor exposure measurement and potentially inadequate control of confounding, a firm conclusion remains beyond reach. For the other outcomes (stillbirth, IUGR, low birthweight, preterm birth and miscarriage) the evidence for any associations was equivocal at best, but some leads warrant further investigation. Improved exposure assessment methods are needed to obtain a more reliable assessment of any risks.
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DOI: 10.1111/j.1365-3016.2010.01165.x
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ISTEX:03574126025BE47394354BA5350B77ED64020422Le document en format XML
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Living near agricultural pesticide applications and the risk of adverse reproductive outcomes: a review of the literature. Paediatric and Perinatal Epidemiology 2010. Over the last decade, there has been growing concern about the possible health effects, including a number of adverse reproductive outcomes, from pesticide exposure of people living near agricultural fields. This systematic review evaluates the current epidemiological evidence on the association between living near agricultural pesticide applications and adverse reproductive outcomes, including congenital malformations, stillbirth, intrauterine growth retardation (IUGR), low birthweight, preterm birth and miscarriage. We identified and reviewed 25 studies from a systematic search of the main scientific databases and other sources published in 1950–2007. Study methods and main results were summarised and tabulated according to the year of study, design and type of adverse reproductive outcome. The levels of evidence for reproductive toxicity in humans contributed by each study were assessed and the main limitations associated with these studies discussed. Residential proximity to agricultural pesticide applications may be an important source of ambient environmental exposure, but because of the underlying methodological difficulties, the strength of evidence for its relationship with adverse reproductive outcomes is generally weak and varied between outcomes. The evidence suggested an association for congenital malformations, but because of methodological limitations, such as poor exposure measurement and potentially inadequate control of confounding, a firm conclusion remains beyond reach. For the other outcomes (stillbirth, IUGR, low birthweight, preterm birth and miscarriage) the evidence for any associations was equivocal at best, but some leads warrant further investigation. Improved exposure assessment methods are needed to obtain a more reliable assessment of any risks.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Adeleh Shirangi</name><affiliations><json:string>MRC‐HPA Centre for Environment and Health, Department of Epidemiology and Biostatistics, Imperial College London, London, UK</json:string><json:string>Telethon Institute for Child Health Research, Centre for Child Health Research</json:string><json:string>E-mail: ashirangi@ichr.uwa.edu.au</json:string></affiliations></json:item><json:item><name>Mark Nieuwenhuijsen</name><affiliations><json:string>MRC‐HPA Centre for Environment and Health, Department of Epidemiology and Biostatistics, Imperial College London, London, UK</json:string><json:string>Center for Research in Environmental Epidemiology (CREAL), Barcelona, Spain</json:string></affiliations></json:item><json:item><name>Danielle Vienneau</name><affiliations><json:string>MRC‐HPA Centre for Environment and Health, Department of Epidemiology and Biostatistics, Imperial College London, London, UK</json:string></affiliations></json:item><json:item><name>C.D'Arcy J. 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Living near agricultural pesticide applications and the risk of adverse reproductive outcomes: a review of the literature. Paediatric and Perinatal Epidemiology 2010. Over the last decade, there has been growing concern about the possible health effects, including a number of adverse reproductive outcomes, from pesticide exposure of people living near agricultural fields. This systematic review evaluates the current epidemiological evidence on the association between living near agricultural pesticide applications and adverse reproductive outcomes, including congenital malformations, stillbirth, intrauterine growth retardation (IUGR), low birthweight, preterm birth and miscarriage. We identified and reviewed 25 studies from a systematic search of the main scientific databases and other sources published in 1950–2007. Study methods and main results were summarised and tabulated according to the year of study, design and type of adverse reproductive outcome. The levels of evidence for reproductive toxicity in humans contributed by each study were assessed and the main limitations associated with these studies discussed. Residential proximity to agricultural pesticide applications may be an important source of ambient environmental exposure, but because of the underlying methodological difficulties, the strength of evidence for its relationship with adverse reproductive outcomes is generally weak and varied between outcomes. The evidence suggested an association for congenital malformations, but because of methodological limitations, such as poor exposure measurement and potentially inadequate control of confounding, a firm conclusion remains beyond reach. For the other outcomes (stillbirth, IUGR, low birthweight, preterm birth and miscarriage) the evidence for any associations was equivocal at best, but some leads warrant further investigation. Improved exposure assessment methods are needed to obtain a more reliable assessment of any risks.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>keywords</head><item><term>pesticides</term></item><item><term>congenital malformations</term></item><item><term>outcome of pregnancy</term></item><item><term>miscarriage</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2011-03">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/03574126025BE47394354BA5350B77ED64020422/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Ltd</publisherName><publisherLoc>Oxford, UK</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1365-3016</doi><issn type="print">0269-5022</issn><issn type="electronic">1365-3016</issn><idGroup><id type="product" value="PPE"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="PAEDIATRIC PERINATAL EPIDEMIOLOGY">Paediatric and Perinatal Epidemiology</title></titleGroup></publicationMeta><publicationMeta level="part" position="03102"><doi origin="wiley">10.1111/ppe.2011.25.issue-2</doi><numberingGroup><numbering type="journalVolume" number="25">25</numbering><numbering type="journalIssue" number="2">2</numbering></numberingGroup><coverDate startDate="2011-03">March 2011</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="11" status="forIssue"><doi origin="wiley">10.1111/j.1365-3016.2010.01165.x</doi><idGroup><id type="unit" value="PPE1165"></id></idGroup><countGroup><count type="pageTotal" number="20"></count></countGroup><titleGroup><title type="tocHeading1">Environmental effects</title></titleGroup><copyright>© 2010 Blackwell Publishing Ltd.</copyright><eventGroup><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.4.4 mode:FullText" date="2011-02-01"></event><event type="publishedOnlineEarlyUnpaginated" date="2010-12-09"></event><event type="firstOnline" date="2010-12-09"></event><event type="publishedOnlineFinalForm" date="2011-02-01"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-07"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-11-03"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="172">172</numbering><numbering type="pageLast" number="191">191</numbering></numberingGroup><correspondenceTo>Dr Adeleh Shirangi, Telethon Institute for Child Health Research, Centre for Child Health Research, The University of Western Australia, 100 Roberts Road, Subiaco, WA 6008, Australia. E‐mail: <email>ashirangi@ichr.uwa.edu.au</email>.</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:PPE.PPE1165.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="0"></count><count type="tableTotal" number="4"></count><count type="formulaTotal" number="0"></count><count type="referenceTotal" number="95"></count><count type="wordTotal" number="11780"></count><count type="linksPubMed" number="0"></count><count type="linksCrossRef" number="0"></count></countGroup><titleGroup><title type="main">Living near agricultural pesticide applications and the risk of adverse reproductive outcomes: a review of the literature</title><title type="shortAuthors"><i>A. Shirangi</i> et al.</title><title type="short">Reproductive outcomes of pesticides</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1 #a2" corresponding="yes"><personName><givenNames>Adeleh</givenNames><familyName>Shirangi</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a1 #a4"><personName><givenNames>Mark</givenNames><familyName>Nieuwenhuijsen</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a1"><personName><givenNames>Danielle</givenNames><familyName>Vienneau</familyName></personName></creator><creator creatorRole="author" xml:id="cr4" affiliationRef="#a3"><personName><givenNames>C.D'Arcy J.</givenNames><familyName>Holman</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1" countryCode="GB"><unparsedAffiliation>MRC‐HPA Centre for Environment and Health, Department of Epidemiology and Biostatistics, Imperial College London, London, UK</unparsedAffiliation></affiliation><affiliation xml:id="a2"><unparsedAffiliation>Telethon Institute for Child Health Research, Centre for Child Health Research</unparsedAffiliation></affiliation><affiliation xml:id="a3" countryCode="AU"><unparsedAffiliation>School of Population Health, The University of Western Australia, Subiaco, WA, Australia</unparsedAffiliation></affiliation><affiliation xml:id="a4" countryCode="ES"><unparsedAffiliation>Center for Research in Environmental Epidemiology (CREAL), Barcelona, Spain</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1">pesticides</keyword><keyword xml:id="k2">congenital malformations</keyword><keyword xml:id="k3">outcome of pregnancy</keyword><keyword xml:id="k4">miscarriage</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Summary</title><p>Shirangi A, Nieuwenhuijsen M, Vienneau D, Holman CDJ. Living near agricultural pesticide applications and the risk of adverse reproductive outcomes: a review of the literature. <i>Paediatric and Perinatal Epidemiology</i> 2010.</p><p>Over the last decade, there has been growing concern about the possible health effects, including a number of adverse reproductive outcomes, from pesticide exposure of people living near agricultural fields. This systematic review evaluates the current epidemiological evidence on the association between living near agricultural pesticide applications and adverse reproductive outcomes, including congenital malformations, stillbirth, intrauterine growth retardation (IUGR), low birthweight, preterm birth and miscarriage.</p><p>We identified and reviewed 25 studies from a systematic search of the main scientific databases and other sources published in 1950–2007. Study methods and main results were summarised and tabulated according to the year of study, design and type of adverse reproductive outcome. The levels of evidence for reproductive toxicity in humans contributed by each study were assessed and the main limitations associated with these studies discussed.</p><p>Residential proximity to agricultural pesticide applications may be an important source of ambient environmental exposure, but because of the underlying methodological difficulties, the strength of evidence for its relationship with adverse reproductive outcomes is generally weak and varied between outcomes. The evidence suggested an association for congenital malformations, but because of methodological limitations, such as poor exposure measurement and potentially inadequate control of confounding, a firm conclusion remains beyond reach. For the other outcomes (stillbirth, IUGR, low birthweight, preterm birth and miscarriage) the evidence for any associations was equivocal at best, but some leads warrant further investigation. Improved exposure assessment methods are needed to obtain a more reliable assessment of any risks.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Living near agricultural pesticide applications and the risk of adverse reproductive outcomes: a review of the literature</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Reproductive outcomes of pesticides</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Living near agricultural pesticide applications and the risk of adverse reproductive outcomes: a review of the literature</title></titleInfo><name type="personal"><namePart type="given">Adeleh</namePart><namePart type="family">Shirangi</namePart><affiliation>MRC‐HPA Centre for Environment and Health, Department of Epidemiology and Biostatistics, Imperial College London, London, UK</affiliation><affiliation>Telethon Institute for Child Health Research, Centre for Child Health Research</affiliation><affiliation>E-mail: ashirangi@ichr.uwa.edu.au</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Mark</namePart><namePart type="family">Nieuwenhuijsen</namePart><affiliation>MRC‐HPA Centre for Environment and Health, Department of Epidemiology and Biostatistics, Imperial College London, London, UK</affiliation><affiliation>Center for Research in Environmental Epidemiology (CREAL), Barcelona, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Danielle</namePart><namePart type="family">Vienneau</namePart><affiliation>MRC‐HPA Centre for Environment and Health, Department of Epidemiology and Biostatistics, Imperial College London, London, UK</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.D'Arcy J.</namePart><namePart type="family">Holman</namePart><affiliation>School of Population Health, The University of Western Australia, Subiaco, WA, Australia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">2011-03</dateIssued><copyrightDate encoding="w3cdtf">2011</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="tables">4</extent><extent unit="references">95</extent><extent unit="words">11780</extent></physicalDescription><abstract lang="en">Shirangi A, Nieuwenhuijsen M, Vienneau D, Holman CDJ. Living near agricultural pesticide applications and the risk of adverse reproductive outcomes: a review of the literature. Paediatric and Perinatal Epidemiology 2010. Over the last decade, there has been growing concern about the possible health effects, including a number of adverse reproductive outcomes, from pesticide exposure of people living near agricultural fields. This systematic review evaluates the current epidemiological evidence on the association between living near agricultural pesticide applications and adverse reproductive outcomes, including congenital malformations, stillbirth, intrauterine growth retardation (IUGR), low birthweight, preterm birth and miscarriage. We identified and reviewed 25 studies from a systematic search of the main scientific databases and other sources published in 1950–2007. Study methods and main results were summarised and tabulated according to the year of study, design and type of adverse reproductive outcome. The levels of evidence for reproductive toxicity in humans contributed by each study were assessed and the main limitations associated with these studies discussed. Residential proximity to agricultural pesticide applications may be an important source of ambient environmental exposure, but because of the underlying methodological difficulties, the strength of evidence for its relationship with adverse reproductive outcomes is generally weak and varied between outcomes. The evidence suggested an association for congenital malformations, but because of methodological limitations, such as poor exposure measurement and potentially inadequate control of confounding, a firm conclusion remains beyond reach. For the other outcomes (stillbirth, IUGR, low birthweight, preterm birth and miscarriage) the evidence for any associations was equivocal at best, but some leads warrant further investigation. Improved exposure assessment methods are needed to obtain a more reliable assessment of any risks.</abstract><subject lang="en"><genre>keywords</genre><topic>pesticides</topic><topic>congenital malformations</topic><topic>outcome of pregnancy</topic><topic>miscarriage</topic></subject><relatedItem type="host"><titleInfo><title>Paediatric and Perinatal Epidemiology</title></titleInfo><genre type="journal">journal</genre><identifier type="ISSN">0269-5022</identifier><identifier type="eISSN">1365-3016</identifier><identifier type="DOI">10.1111/(ISSN)1365-3016</identifier><identifier type="PublisherID">PPE</identifier><part><date>2011</date><detail type="volume"><caption>vol.</caption><number>25</number></detail><detail type="issue"><caption>no.</caption><number>2</number></detail><extent unit="pages"><start>172</start><end>191</end><total>20</total></extent></part></relatedItem><identifier type="istex">03574126025BE47394354BA5350B77ED64020422</identifier><identifier type="DOI">10.1111/j.1365-3016.2010.01165.x</identifier><identifier type="ArticleID">PPE1165</identifier><accessCondition type="use and reproduction" contentType="copyright">© 2010 Blackwell Publishing Ltd.</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Blackwell Publishing Ltd</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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