Impaired cytokine production in whole blood cell cultures of patients with gynaecological carcinomas in different clinical stages.
Identifieur interne : 000142 ( Pmc/Corpus ); précédent : 000141; suivant : 000143Impaired cytokine production in whole blood cell cultures of patients with gynaecological carcinomas in different clinical stages.
Auteurs : U. Els Sser-Beile ; S. Von Kleist ; W. Sauther ; H. Gallati ; J. S. MöntingSource :
- British Journal of Cancer [ 0007-0920 ] ; 1993.
Abstract
The production of the cytokines IFN-gamma, IL-1-alpha, IL-2 and TNF-alpha was investigated in mitogen-stimulated, whole blood cell culture from 239 untreated patients with primary gynaecological carcinomas (breast, cervix, ovary, endometrium), and 191 healthy female controls. The cytokines were measured in the 4-day post-induction supernatants by a sensitive enzymoimmunological assay. In the blood cell cultures of all four groups of cancer patients, significantly lower values of IFN-gamma (P < or = 0.001), IL-2 (P < or = 0.01) and IL-1 alpha (P < or = 0.01) were found as compared to the controls, although lymphocyte and monocyte counts were almost identical. Grouping the tumour patients into different clinical stages we could show in the four groups of carcinomas a gradual depression of the cytokine production according to growing tumour burden.
Url:
PubMed: 8318418
PubMed Central: 1968320
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Impaired cytokine production in whole blood cell cultures of patients with gynaecological carcinomas in different clinical stages.</title><author><name sortKey="Els Sser Beile, U" sort="Els Sser Beile, U" uniqKey="Els Sser Beile U" first="U." last="Els Sser-Beile">U. Els Sser-Beile</name></author><author><name sortKey="Von Kleist, S" sort="Von Kleist, S" uniqKey="Von Kleist S" first="S." last="Von Kleist">S. Von Kleist</name></author><author><name sortKey="Sauther, W" sort="Sauther, W" uniqKey="Sauther W" first="W." last="Sauther">W. Sauther</name></author><author><name sortKey="Gallati, H" sort="Gallati, H" uniqKey="Gallati H" first="H." last="Gallati">H. Gallati</name></author><author><name sortKey="Monting, J S" sort="Monting, J S" uniqKey="Monting J" first="J. S." last="Mönting">J. S. Mönting</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">8318418</idno><idno type="pmc">1968320</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968320</idno><idno type="RBID">PMC:1968320</idno><date when="1993">1993</date><idno type="wicri:Area/Pmc/Corpus">000142</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000142</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Impaired cytokine production in whole blood cell cultures of patients with gynaecological carcinomas in different clinical stages.</title><author><name sortKey="Els Sser Beile, U" sort="Els Sser Beile, U" uniqKey="Els Sser Beile U" first="U." last="Els Sser-Beile">U. Els Sser-Beile</name></author><author><name sortKey="Von Kleist, S" sort="Von Kleist, S" uniqKey="Von Kleist S" first="S." last="Von Kleist">S. Von Kleist</name></author><author><name sortKey="Sauther, W" sort="Sauther, W" uniqKey="Sauther W" first="W." last="Sauther">W. Sauther</name></author><author><name sortKey="Gallati, H" sort="Gallati, H" uniqKey="Gallati H" first="H." last="Gallati">H. Gallati</name></author><author><name sortKey="Monting, J S" sort="Monting, J S" uniqKey="Monting J" first="J. S." last="Mönting">J. S. Mönting</name></author></analytic><series><title level="j">British Journal of Cancer</title><idno type="ISSN">0007-0920</idno><idno type="eISSN">1532-1827</idno><imprint><date when="1993">1993</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The production of the cytokines IFN-gamma, IL-1-alpha, IL-2 and TNF-alpha was investigated in mitogen-stimulated, whole blood cell culture from 239 untreated patients with primary gynaecological carcinomas (breast, cervix, ovary, endometrium), and 191 healthy female controls. The cytokines were measured in the 4-day post-induction supernatants by a sensitive enzymoimmunological assay. In the blood cell cultures of all four groups of cancer patients, significantly lower values of IFN-gamma (P < or = 0.001), IL-2 (P < or = 0.01) and IL-1 alpha (P < or = 0.01) were found as compared to the controls, although lymphocyte and monocyte counts were almost identical. Grouping the tumour patients into different clinical stages we could show in the four groups of carcinomas a gradual depression of the cytokine production according to growing tumour burden.</p></div></front></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Br J Cancer</journal-id><journal-title>British Journal of Cancer</journal-title><issn pub-type="ppub">0007-0920</issn><issn pub-type="epub">1532-1827</issn></journal-meta><article-meta><article-id pub-id-type="pmid">8318418</article-id><article-id pub-id-type="pmc">1968320</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title>Impaired cytokine production in whole blood cell cultures of patients with gynaecological carcinomas in different clinical stages.</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Elsässer-Beile</surname><given-names>U.</given-names></name></contrib><contrib contrib-type="author"><name><surname>von Kleist</surname><given-names>S.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Sauther</surname><given-names>W.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Gallati</surname><given-names>H.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Mönting</surname><given-names>J. S.</given-names></name></contrib></contrib-group><aff>Institute of Immunobiology, Medical Faculty, University of Freiburg, Germany.</aff><pub-date pub-type="ppub"><month>7</month><year>1993</year></pub-date><volume>68</volume><issue>1</issue><fpage>32</fpage><lpage>36</lpage><abstract><p>The production of the cytokines IFN-gamma, IL-1-alpha, IL-2 and TNF-alpha was investigated in mitogen-stimulated, whole blood cell culture from 239 untreated patients with primary gynaecological carcinomas (breast, cervix, ovary, endometrium), and 191 healthy female controls. The cytokines were measured in the 4-day post-induction supernatants by a sensitive enzymoimmunological assay. In the blood cell cultures of all four groups of cancer patients, significantly lower values of IFN-gamma (P < or = 0.001), IL-2 (P < or = 0.01) and IL-1 alpha (P < or = 0.01) were found as compared to the controls, although lymphocyte and monocyte counts were almost identical. Grouping the tumour patients into different clinical stages we could show in the four groups of carcinomas a gradual depression of the cytokine production according to growing tumour burden.</p></abstract></article-meta></front><body><supplementary-material content-type="scanned-pages"><graphic xlink:href="brjcancer00197-0042.tif" xlink:title="scanned-page" xlink:role="32" mimetype="image" mime-subtype="tiff"></graphic><graphic xlink:href="brjcancer00197-0043.tif" xlink:title="scanned-page" xlink:role="33" mimetype="image" mime-subtype="tiff"></graphic><graphic xlink:href="brjcancer00197-0044.tif" xlink:title="scanned-page" xlink:role="34" mimetype="image" mime-subtype="tiff"></graphic><graphic xlink:href="brjcancer00197-0045.tif" xlink:title="scanned-page" xlink:role="35" mimetype="image" mime-subtype="tiff"></graphic><graphic xlink:href="brjcancer00197-0046.tif" xlink:title="scanned-page" xlink:role="36" mimetype="image" mime-subtype="tiff"></graphic></supplementary-material></body></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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