Skin phototoxicity variations during repeated bath PUVA exposures to 8‐methoxypsoralen and trimethylpsoralen
Identifieur interne : 003247 ( Main/Exploration ); précédent : 003246; suivant : 003248Skin phototoxicity variations during repeated bath PUVA exposures to 8‐methoxypsoralen and trimethylpsoralen
Auteurs : Leena M. Koulu [Finlande] ; Christer T. Jansén [Finlande]Source :
- Clinical and Experimental Dermatology [ 0307-6938 ] ; 1984-01.
Abstract
When applying psoralens topically to the skin by a 15‐min bathing procedure, a dilute trioxsalen solution (0.2 mg/l) produced a ten‐ to fifteen‐fold stronger skin photosensitization than a two‐fold more concentrated methoxsalen solution. There were both inter‐ and intra‐individual variations in psoralen‐induced photosensitivity when the treatments were repeated five times in each of five test subjects. In particular, the skin UV‐A sensitivity increased progressively at each subsequent psoralen bathing, but this did not seem to be due to an accumulation of the psoralen in the skin.
Url:
DOI: 10.1111/j.1365-2230.1984.tb00757.x
Affiliations:
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