Skin phototoxicity variations during repeated bath PUVA exposures to 8‐methoxypsoralen and trimethylpsoralen
Identifieur interne : 003A48 ( Istex/Corpus ); précédent : 003A47; suivant : 003A49Skin phototoxicity variations during repeated bath PUVA exposures to 8‐methoxypsoralen and trimethylpsoralen
Auteurs : Leena M. Koulu ; Christer T. JansénSource :
- Clinical and Experimental Dermatology [ 0307-6938 ] ; 1984-01.
Abstract
When applying psoralens topically to the skin by a 15‐min bathing procedure, a dilute trioxsalen solution (0.2 mg/l) produced a ten‐ to fifteen‐fold stronger skin photosensitization than a two‐fold more concentrated methoxsalen solution. There were both inter‐ and intra‐individual variations in psoralen‐induced photosensitivity when the treatments were repeated five times in each of five test subjects. In particular, the skin UV‐A sensitivity increased progressively at each subsequent psoralen bathing, but this did not seem to be due to an accumulation of the psoralen in the skin.
Url:
DOI: 10.1111/j.1365-2230.1984.tb00757.x
Links to Exploration step
ISTEX:AA8FBE90D01E0CD20B70C9FFEBDA9612055DCA90Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Skin phototoxicity variations during repeated bath PUVA exposures to 8‐methoxypsoralen and trimethylpsoralen</title><author><name sortKey="Koulu, Leena M" sort="Koulu, Leena M" uniqKey="Koulu L" first="Leena M." last="Koulu">Leena M. Koulu</name><affiliation><mods:affiliation>Department of Dermatology, University of Turku, SF‐20520 Turku 52, Finland</mods:affiliation></affiliation></author><author><name sortKey="Jansen, Christer T" sort="Jansen, Christer T" uniqKey="Jansen C" first="Christer T." last="Jansén">Christer T. Jansén</name><affiliation><mods:affiliation>Department of Dermatology, University of Turku, SF‐20520 Turku 52, Finland</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:AA8FBE90D01E0CD20B70C9FFEBDA9612055DCA90</idno><date when="1984" year="1984">1984</date><idno type="doi">10.1111/j.1365-2230.1984.tb00757.x</idno><idno type="url">https://api.istex.fr/document/AA8FBE90D01E0CD20B70C9FFEBDA9612055DCA90/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">003A48</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Skin phototoxicity variations during repeated bath PUVA exposures to 8‐methoxypsoralen and trimethylpsoralen</title><author><name sortKey="Koulu, Leena M" sort="Koulu, Leena M" uniqKey="Koulu L" first="Leena M." last="Koulu">Leena M. Koulu</name><affiliation><mods:affiliation>Department of Dermatology, University of Turku, SF‐20520 Turku 52, Finland</mods:affiliation></affiliation></author><author><name sortKey="Jansen, Christer T" sort="Jansen, Christer T" uniqKey="Jansen C" first="Christer T." last="Jansén">Christer T. Jansén</name><affiliation><mods:affiliation>Department of Dermatology, University of Turku, SF‐20520 Turku 52, Finland</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Clinical and Experimental Dermatology</title><idno type="ISSN">0307-6938</idno><idno type="eISSN">1365-2230</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="1984-01">1984-01</date><biblScope unit="volume">9</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="64">64</biblScope><biblScope unit="page" to="69">69</biblScope></imprint><idno type="ISSN">0307-6938</idno></series><idno type="istex">AA8FBE90D01E0CD20B70C9FFEBDA9612055DCA90</idno><idno type="DOI">10.1111/j.1365-2230.1984.tb00757.x</idno><idno type="ArticleID">CED64</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0307-6938</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">When applying psoralens topically to the skin by a 15‐min bathing procedure, a dilute trioxsalen solution (0.2 mg/l) produced a ten‐ to fifteen‐fold stronger skin photosensitization than a two‐fold more concentrated methoxsalen solution. There were both inter‐ and intra‐individual variations in psoralen‐induced photosensitivity when the treatments were repeated five times in each of five test subjects. In particular, the skin UV‐A sensitivity increased progressively at each subsequent psoralen bathing, but this did not seem to be due to an accumulation of the psoralen in the skin.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>LEENA M. KOULU</name><affiliations><json:string>Department of Dermatology, University of Turku, SF‐20520 Turku 52, Finland</json:string></affiliations></json:item><json:item><name>CHRISTER T. JANSÉN</name><affiliations><json:string>Department of Dermatology, University of Turku, SF‐20520 Turku 52, Finland</json:string></affiliations></json:item></author><articleId><json:string>CED64</json:string></articleId><language><json:string>eng</json:string></language><abstract>When applying psoralens topically to the skin by a 15‐min bathing procedure, a dilute trioxsalen solution (0.2 mg/l) produced a ten‐ to fifteen‐fold stronger skin photosensitization than a two‐fold more concentrated methoxsalen solution. There were both inter‐ and intra‐individual variations in psoralen‐induced photosensitivity when the treatments were repeated five times in each of five test subjects. In particular, the skin UV‐A sensitivity increased progressively at each subsequent psoralen bathing, but this did not seem to be due to an accumulation of the psoralen in the skin.</abstract><qualityIndicators><score>3.63</score><pdfVersion>1.4</pdfVersion><pdfPageSize>512 x 685 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>0</keywordCount><abstractCharCount>587</abstractCharCount><pdfWordCount>2098</pdfWordCount><pdfCharCount>12635</pdfCharCount><pdfPageCount>7</pdfPageCount><abstractWordCount>86</abstractWordCount></qualityIndicators><title>Skin phototoxicity variations during repeated bath PUVA exposures to 8‐methoxypsoralen and trimethylpsoralen</title><genre><json:string>article</json:string></genre><host><volume>9</volume><publisherId><json:string>CED</json:string></publisherId><pages><total>6</total><last>69</last><first>64</first></pages><issn><json:string>0307-6938</json:string></issn><issue>1</issue><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1365-2230</json:string></eissn><title>Clinical and Experimental Dermatology</title><doi><json:string>10.1111/(ISSN)1365-2230</json:string></doi></host><publicationDate>1984</publicationDate><copyrightDate>1984</copyrightDate><doi><json:string>10.1111/j.1365-2230.1984.tb00757.x</json:string></doi><id>AA8FBE90D01E0CD20B70C9FFEBDA9612055DCA90</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/AA8FBE90D01E0CD20B70C9FFEBDA9612055DCA90/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/AA8FBE90D01E0CD20B70C9FFEBDA9612055DCA90/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/AA8FBE90D01E0CD20B70C9FFEBDA9612055DCA90/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Skin phototoxicity variations during repeated bath PUVA exposures to 8‐methoxypsoralen and trimethylpsoralen</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><availability><p>WILEY</p></availability><date>1984</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Skin phototoxicity variations during repeated bath PUVA exposures to 8‐methoxypsoralen and trimethylpsoralen</title><author><persName><forename type="first">LEENA M.</forename><surname>KOULU</surname></persName><note type="correspondence"><p>Correspondence: Leena Koula, M.D., Department of Dermatology, University of Turku, SF‐20520 Turku 52, Finland.</p></note><affiliation>Department of Dermatology, University of Turku, SF‐20520 Turku 52, Finland</affiliation></author><author><persName><forename type="first">CHRISTER T.</forename><surname>JANSÉN</surname></persName><affiliation>Department of Dermatology, University of Turku, SF‐20520 Turku 52, Finland</affiliation></author></analytic><monogr><title level="j">Clinical and Experimental Dermatology</title><idno type="pISSN">0307-6938</idno><idno type="eISSN">1365-2230</idno><idno type="DOI">10.1111/(ISSN)1365-2230</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="1984-01"></date><biblScope unit="volume">9</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="64">64</biblScope><biblScope unit="page" to="69">69</biblScope></imprint></monogr><idno type="istex">AA8FBE90D01E0CD20B70C9FFEBDA9612055DCA90</idno><idno type="DOI">10.1111/j.1365-2230.1984.tb00757.x</idno><idno type="ArticleID">CED64</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1984</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>When applying psoralens topically to the skin by a 15‐min bathing procedure, a dilute trioxsalen solution (0.2 mg/l) produced a ten‐ to fifteen‐fold stronger skin photosensitization than a two‐fold more concentrated methoxsalen solution. There were both inter‐ and intra‐individual variations in psoralen‐induced photosensitivity when the treatments were repeated five times in each of five test subjects. In particular, the skin UV‐A sensitivity increased progressively at each subsequent psoralen bathing, but this did not seem to be due to an accumulation of the psoralen in the skin.</p></abstract></profileDesc><revisionDesc><change when="1984-01">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/AA8FBE90D01E0CD20B70C9FFEBDA9612055DCA90/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Ltd</publisherName><publisherLoc>Oxford, UK</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1365-2230</doi><issn type="print">0307-6938</issn><issn type="electronic">1365-2230</issn><idGroup><id type="product" value="CED"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="CLINICAL EXPERIMENTAL DERMATOLOGY">Clinical and Experimental Dermatology</title></titleGroup></publicationMeta><publicationMeta level="part" position="01001"><doi origin="wiley">10.1111/ced.1984.9.issue-1</doi><numberingGroup><numbering type="journalVolume" number="9">9</numbering><numbering type="journalIssue" number="1">1</numbering></numberingGroup><coverDate startDate="1984-01">January 1984</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="0006400" status="forIssue"><doi origin="wiley">10.1111/j.1365-2230.1984.tb00757.x</doi><idGroup><id type="unit" value="CED64"></id></idGroup><countGroup><count type="pageTotal" number="6"></count></countGroup><titleGroup><title type="tocHeading1">Original Articles</title></titleGroup><eventGroup><event type="firstOnline" date="2006-04-27"></event><event type="publishedOnlineFinalForm" date="2006-04-27"></event><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.3.2 mode:FullText source:HeaderRef result:HeaderRef" date="2010-03-09"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-01-09"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-16"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="64">64</numbering><numbering type="pageLast" number="69">69</numbering></numberingGroup><correspondenceTo>Leena Koula, M.D., Department of Dermatology, University of Turku, SF‐20520 Turku 52, Finland.</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:CED.CED64.pdf"></link></linkGroup></publicationMeta><contentMeta><unparsedEditorialHistory>Accepted for publication 4 January 1983</unparsedEditorialHistory><countGroup><count type="referenceTotal" number="13"></count><count type="linksCrossRef" number="3"></count></countGroup><titleGroup><title type="main">Skin phototoxicity variations during repeated bath PUVA exposures to 8‐methoxypsoralen and trimethylpsoralen</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1" corresponding="yes"><personName><givenNames>LEENA M.</givenNames><familyName>KOULU</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a1"><personName><givenNames>CHRISTER T.</givenNames><familyName>JANSÉN</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1" countryCode="FI"><unparsedAffiliation>Department of Dermatology, University of Turku, SF‐20520 Turku 52, Finland</unparsedAffiliation></affiliation></affiliationGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Summary</title><p>When applying psoralens topically to the skin by a 15‐min bathing procedure, a dilute trioxsalen solution (0.2 mg/l) produced a ten‐ to fifteen‐fold stronger skin photosensitization than a two‐fold more concentrated methoxsalen solution. There were both inter‐ and intra‐individual variations in psoralen‐induced photosensitivity when the treatments were repeated five times in each of five test subjects. In particular, the skin UV‐A sensitivity increased progressively at each subsequent psoralen bathing, but this did not seem to be due to an accumulation of the psoralen in the skin.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Skin phototoxicity variations during repeated bath PUVA exposures to 8‐methoxypsoralen and trimethylpsoralen</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Skin phototoxicity variations during repeated bath PUVA exposures to 8‐methoxypsoralen and trimethylpsoralen</title></titleInfo><name type="personal"><namePart type="given">LEENA M.</namePart><namePart type="family">KOULU</namePart><affiliation>Department of Dermatology, University of Turku, SF‐20520 Turku 52, Finland</affiliation><description>Correspondence: Leena Koula, M.D., Department of Dermatology, University of Turku, SF‐20520 Turku 52, Finland.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CHRISTER T.</namePart><namePart type="family">JANSÉN</namePart><affiliation>Department of Dermatology, University of Turku, SF‐20520 Turku 52, Finland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">1984-01</dateIssued><edition>Accepted for publication 4 January 1983</edition><copyrightDate encoding="w3cdtf">1984</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="references">13</extent></physicalDescription><abstract lang="en">When applying psoralens topically to the skin by a 15‐min bathing procedure, a dilute trioxsalen solution (0.2 mg/l) produced a ten‐ to fifteen‐fold stronger skin photosensitization than a two‐fold more concentrated methoxsalen solution. There were both inter‐ and intra‐individual variations in psoralen‐induced photosensitivity when the treatments were repeated five times in each of five test subjects. In particular, the skin UV‐A sensitivity increased progressively at each subsequent psoralen bathing, but this did not seem to be due to an accumulation of the psoralen in the skin.</abstract><relatedItem type="host"><titleInfo><title>Clinical and Experimental Dermatology</title></titleInfo><genre type="Journal">journal</genre><identifier type="ISSN">0307-6938</identifier><identifier type="eISSN">1365-2230</identifier><identifier type="DOI">10.1111/(ISSN)1365-2230</identifier><identifier type="PublisherID">CED</identifier><part><date>1984</date><detail type="volume"><caption>vol.</caption><number>9</number></detail><detail type="issue"><caption>no.</caption><number>1</number></detail><extent unit="pages"><start>64</start><end>69</end><total>6</total></extent></part></relatedItem><identifier type="istex">AA8FBE90D01E0CD20B70C9FFEBDA9612055DCA90</identifier><identifier type="DOI">10.1111/j.1365-2230.1984.tb00757.x</identifier><identifier type="ArticleID">CED64</identifier><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Blackwell Publishing Ltd</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Informatique/explor/ScrumV1/Data/Istex/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003A48 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Corpus/biblio.hfd -nk 003A48 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Informatique
|area= ScrumV1
|flux= Istex
|étape= Corpus
|type= RBID
|clé= ISTEX:AA8FBE90D01E0CD20B70C9FFEBDA9612055DCA90
|texte= Skin phototoxicity variations during repeated bath PUVA exposures to 8‐methoxypsoralen and trimethylpsoralen
}}
| This area was generated with Dilib version V0.6.39. |  |