Factors affecting amylase output by the isolated perfused liver
Identifieur interne : 005614 ( Main/Curation ); précédent : 005613; suivant : 005615Factors affecting amylase output by the isolated perfused liver
Auteurs : Robert L. Mcgeachin [États-Unis] ; Betty Ann Potter [États-Unis] ; Agamemnon Despopoulos [États-Unis]Source :
- Archives of Biochemistry and Biophysics [ 0003-9861 ] ; 1962.
Abstract
During the perfusion of isolated rat livers with either diluted whole rat blood or washed red blood cells in a reconstituted medium, the amylase content of the plasma increased two- to threefold, and it was determined that there was a net gain in the amylase of the total system. Amylase was found in the bile excreted from these livers during the perfusion. Administration of N-nitrosodimethylamine to rats produced damage to their livers. Amylase output and bile formation by these damaged livers were below normal as were the amylase contents of the livers themselves. Lack of oxygenation of the perfusing blood resulted in lowered amylase output and bile formation by the perfused livers. No significant effects of the hormones, glucagon and insulin, on amylase production were noted. Epinephrine in large amounts inhibited amylase output probably because of its effect on blood flow through the liver. Amylase was found to be uniformly distributed throughout all lobes of the rat liver.
Url:
DOI: 10.1016/0003-9861(62)90149-2
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