PGE2 Inhibits Glucose Uptake in Isolated Villous Epithelial Cells of the Ovine Small Intestine
Identifieur interne : 003239 ( Istex/Corpus ); précédent : 003238; suivant : 003240PGE2 Inhibits Glucose Uptake in Isolated Villous Epithelial Cells of the Ovine Small Intestine
Auteurs : H. S. Hyun ; S. Arai ; T. Onaga ; S. KatoSource :
- Journal of Veterinary Medicine Series A [ 0931-184X ] ; 1997-02-12.
Abstract
This study was designed to clarify whether PGE2 directly inhibits glucose absorption in villous cells. For this purpose, isolated villous epithelial cells of the ovine small intestine were used, and the uptake of 14C‐labelled glucose in the absorptive epithelial cells was measured in the presence and absence of 0.2 mM phlorizin or 10 μM PGE2. In isolated villous epithelial cells of the small intestine in sheep, net glucose absorption was reduced by 68.2% in the presence of phlorizin. This result indicates that most of the glucose in ruminants is absorbed by the specific transporter SGLT1, which is sensitive to phlorizin. PGE2 decreased glucose absorption by 26.5% in isolated villous epithelial cells in sheep, although this glucose absorption did not change in the presence of phlorizin. This result clearly indicates the PGE2 inhibits the phlorizin‐sensitive glucose absorptive process through direct action on the villous cells of ruminants.
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DOI: 10.1111/j.1439-0442.1997.tb01129.x
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Arai</name><affiliation><mods:affiliation>School of Veterinary Medicine, Chonnam National University, Kwang‐Ju 500‐757, Korea</mods:affiliation></affiliation><affiliation><mods:affiliation>School of Veterinary Medicine, Chonnam National University, Kwang‐Ju 500‐757, KoreaSchool of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069, Japan</mods:affiliation></affiliation></author><author><name sortKey="Onaga, T" sort="Onaga, T" uniqKey="Onaga T" first="T." last="Onaga">T. Onaga</name><affiliation><mods:affiliation>School of Veterinary Medicine, Chonnam National University, Kwang‐Ju 500‐757, Korea</mods:affiliation></affiliation><affiliation><mods:affiliation>School of Veterinary Medicine, Chonnam National University, Kwang‐Ju 500‐757, KoreaSchool of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069, Japan</mods:affiliation></affiliation></author><author><name sortKey="Kato, S" sort="Kato, S" uniqKey="Kato S" first="S." last="Kato">S. 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S." last="Hyun">H. S. Hyun</name><affiliation><mods:affiliation>School of Veterinary Medicine, Chonnam National University, Kwang‐Ju 500‐757, Korea</mods:affiliation></affiliation><affiliation><mods:affiliation>School of Veterinary Medicine, Chonnam National University, Kwang‐Ju 500‐757, KoreaSchool of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069, Japan</mods:affiliation></affiliation></author><author><name sortKey="Arai, S" sort="Arai, S" uniqKey="Arai S" first="S." last="Arai">S. Arai</name><affiliation><mods:affiliation>School of Veterinary Medicine, Chonnam National University, Kwang‐Ju 500‐757, Korea</mods:affiliation></affiliation><affiliation><mods:affiliation>School of Veterinary Medicine, Chonnam National University, Kwang‐Ju 500‐757, KoreaSchool of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069, Japan</mods:affiliation></affiliation></author><author><name sortKey="Onaga, T" sort="Onaga, T" uniqKey="Onaga T" first="T." last="Onaga">T. Onaga</name><affiliation><mods:affiliation>School of Veterinary Medicine, Chonnam National University, Kwang‐Ju 500‐757, Korea</mods:affiliation></affiliation><affiliation><mods:affiliation>School of Veterinary Medicine, Chonnam National University, Kwang‐Ju 500‐757, KoreaSchool of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069, Japan</mods:affiliation></affiliation></author><author><name sortKey="Kato, S" sort="Kato, S" uniqKey="Kato S" first="S." last="Kato">S. 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For this purpose, isolated villous epithelial cells of the ovine small intestine were used, and the uptake of 14C‐labelled glucose in the absorptive epithelial cells was measured in the presence and absence of 0.2 mM phlorizin or 10 μM PGE2. In isolated villous epithelial cells of the small intestine in sheep, net glucose absorption was reduced by 68.2% in the presence of phlorizin. This result indicates that most of the glucose in ruminants is absorbed by the specific transporter SGLT1, which is sensitive to phlorizin. PGE2 decreased glucose absorption by 26.5% in isolated villous epithelial cells in sheep, although this glucose absorption did not change in the presence of phlorizin. This result clearly indicates the PGE2 inhibits the phlorizin‐sensitive glucose absorptive process through direct action on the villous cells of ruminants.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>H. S. Hyun</name><affiliations><json:string>School of Veterinary Medicine, Chonnam National University, Kwang‐Ju 500‐757, Korea</json:string><json:string>School of Veterinary Medicine, Chonnam National University, Kwang‐Ju 500‐757, KoreaSchool of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069, Japan</json:string></affiliations></json:item><json:item><name>S. Arai</name><affiliations><json:string>School of Veterinary Medicine, Chonnam National University, Kwang‐Ju 500‐757, Korea</json:string><json:string>School of Veterinary Medicine, Chonnam National University, Kwang‐Ju 500‐757, KoreaSchool of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069, Japan</json:string></affiliations></json:item><json:item><name>T. Onaga</name><affiliations><json:string>School of Veterinary Medicine, Chonnam National University, Kwang‐Ju 500‐757, Korea</json:string><json:string>School of Veterinary Medicine, Chonnam National University, Kwang‐Ju 500‐757, KoreaSchool of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069, Japan</json:string></affiliations></json:item><json:item><name>S. Kato</name><affiliations><json:string>School of Veterinary Medicine, Chonnam National University, Kwang‐Ju 500‐757, Korea</json:string><json:string>School of Veterinary Medicine, Chonnam National University, Kwang‐Ju 500‐757, KoreaSchool of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069, Japan</json:string></affiliations></json:item></author><articleId><json:string>TBED1129</json:string></articleId><language><json:string>eng</json:string></language><abstract>This study was designed to clarify whether PGE2 directly inhibits glucose absorption in villous cells. 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S.</forename><surname>Hyun</surname></persName><affiliation>School of Veterinary Medicine, Chonnam National University, Kwang‐Ju 500‐757, Korea</affiliation><affiliation>School of Veterinary Medicine, Chonnam National University, Kwang‐Ju 500‐757, KoreaSchool of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069, Japan</affiliation></author><author><persName><forename type="first">S.</forename><surname>Arai</surname></persName><affiliation>School of Veterinary Medicine, Chonnam National University, Kwang‐Ju 500‐757, Korea</affiliation><affiliation>School of Veterinary Medicine, Chonnam National University, Kwang‐Ju 500‐757, KoreaSchool of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069, Japan</affiliation></author><author><persName><forename type="first">T.</forename><surname>Onaga</surname></persName><affiliation>School of Veterinary Medicine, Chonnam National University, Kwang‐Ju 500‐757, Korea</affiliation><affiliation>School of Veterinary Medicine, Chonnam National University, Kwang‐Ju 500‐757, KoreaSchool of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069, Japan</affiliation></author><author><persName><forename type="first">S.</forename><surname>Kato</surname></persName><affiliation>School of Veterinary Medicine, Chonnam National University, Kwang‐Ju 500‐757, Korea</affiliation><affiliation>School of Veterinary Medicine, Chonnam National University, Kwang‐Ju 500‐757, KoreaSchool of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069, Japan</affiliation></author></analytic><monogr><title level="j">Journal of Veterinary Medicine Series A</title><idno type="pISSN">0931-184X</idno><idno type="eISSN">1439-0442</idno><idno type="DOI">10.1111/(ISSN)1439-0442</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="1997-02-12"></date><biblScope unit="volume">44</biblScope><biblScope unit="issue">1‐10</biblScope><biblScope unit="page" from="443">443</biblScope><biblScope unit="page" to="447">447</biblScope></imprint></monogr><idno type="istex">C87D8ACC182BCC9027A088A6F89612E36AF44A5B</idno><idno type="DOI">10.1111/j.1439-0442.1997.tb01129.x</idno><idno type="ArticleID">TBED1129</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1997</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>This study was designed to clarify whether PGE2 directly inhibits glucose absorption in villous cells. For this purpose, isolated villous epithelial cells of the ovine small intestine were used, and the uptake of 14C‐labelled glucose in the absorptive epithelial cells was measured in the presence and absence of 0.2 mM phlorizin or 10 μM PGE2. In isolated villous epithelial cells of the small intestine in sheep, net glucose absorption was reduced by 68.2% in the presence of phlorizin. This result indicates that most of the glucose in ruminants is absorbed by the specific transporter SGLT1, which is sensitive to phlorizin. PGE2 decreased glucose absorption by 26.5% in isolated villous epithelial cells in sheep, although this glucose absorption did not change in the presence of phlorizin. This result clearly indicates the PGE2 inhibits the phlorizin‐sensitive glucose absorptive process through direct action on the villous cells of ruminants.</p></abstract></profileDesc><revisionDesc><change when="1997-02-12">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/C87D8ACC182BCC9027A088A6F89612E36AF44A5B/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Ltd</publisherName><publisherLoc>Oxford, UK</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1439-0442</doi><issn type="print">0931-184X</issn><issn type="electronic">1439-0442</issn><idGroup><id type="product" value="TBED"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="JOURNAL OF VETERINARY MEDICINE SERIES A">Journal of Veterinary Medicine Series A</title></titleGroup></publicationMeta><publicationMeta level="part" position="02001"><doi origin="wiley">10.1111/tbed.1997.44.issue-1-10</doi><numberingGroup><numbering type="journalVolume" number="44">44</numbering><numbering type="journalIssue">1‐10</numbering></numberingGroup><coverDate startDate="1997-02-12">February‐December 1997</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="48" status="forIssue"><doi origin="wiley">10.1111/j.1439-0442.1997.tb01129.x</doi><idGroup><id type="unit" value="TBED1129"></id></idGroup><countGroup><count type="pageTotal" number="5"></count></countGroup><titleGroup><title type="tocHeading1">Original Paper/Originalarbeiten</title></titleGroup><copyright>© 1997 Blackwell Verlag GmbH</copyright><eventGroup><event type="firstOnline" date="2010-05-13"></event><event type="publishedOnlineFinalForm" date="2010-05-13"></event><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.3.6 mode:FullText source:HeaderRef result:HeaderRef" date="2010-05-17"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-10"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-31"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="443">443</numbering><numbering type="pageLast" number="447">447</numbering></numberingGroup><correspondenceTo><lineatedText><line>School of Veterinary Medicine, Chonnam National University, Kwang‐Ju 500‐757, Korea</line><line>School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069, Japan</line></lineatedText></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:TBED.TBED1129.pdf"></link></linkGroup></publicationMeta><contentMeta><unparsedEditorialHistory>April 7, 1997</unparsedEditorialHistory><countGroup><count type="referenceTotal" number="14"></count><count type="linksCrossRef" number="8"></count></countGroup><titleGroup><title type="main">PGE<sub>2</sub> Inhibits Glucose Uptake in Isolated Villous Epithelial Cells of the Ovine Small Intestine</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1" corresponding="yes"><personName><givenNames>H. S.</givenNames><familyName>Hyun</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a1" corresponding="yes"><personName><givenNames>S.</givenNames><familyName>Arai</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a1" corresponding="yes"><personName><givenNames>T.</givenNames><familyName>Onaga</familyName></personName></creator><creator creatorRole="author" xml:id="cr4" affiliationRef="#a1" corresponding="yes"><personName><givenNames>S.</givenNames><familyName>Kato</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1"><unparsedAffiliation>School of Veterinary Medicine, Chonnam National University, Kwang‐Ju 500‐757, Korea</unparsedAffiliation></affiliation></affiliationGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Summary</title><p>This study was designed to clarify whether PGE<sub>2</sub> directly inhibits glucose absorption in villous cells. For this purpose, isolated villous epithelial cells of the ovine small intestine were used, and the uptake of <sup>14</sup>C‐labelled glucose in the absorptive epithelial cells was measured in the presence and absence of 0.2 mM phlorizin or 10 μM PGE<sub>2</sub>. In isolated villous epithelial cells of the small intestine in sheep, net glucose absorption was reduced by 68.2% in the presence of phlorizin. This result indicates that most of the glucose in ruminants is absorbed by the specific transporter SGLT1, which is sensitive to phlorizin. PGE<sub>2</sub> decreased glucose absorption by 26.5% in isolated villous epithelial cells in sheep, although this glucose absorption did not change in the presence of phlorizin. This result clearly indicates the PGE<sub>2</sub> inhibits the phlorizin‐sensitive glucose absorptive process through direct action on the villous cells of ruminants.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>PGE2 Inhibits Glucose Uptake in Isolated Villous Epithelial Cells of the Ovine Small Intestine</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>PGE</title></titleInfo><name type="personal"><namePart type="given">H. S.</namePart><namePart type="family">Hyun</namePart><affiliation>School of Veterinary Medicine, Chonnam National University, Kwang‐Ju 500‐757, Korea</affiliation><affiliation>School of Veterinary Medicine, Chonnam National University, Kwang‐Ju 500‐757, KoreaSchool of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Arai</namePart><affiliation>School of Veterinary Medicine, Chonnam National University, Kwang‐Ju 500‐757, Korea</affiliation><affiliation>School of Veterinary Medicine, Chonnam National University, Kwang‐Ju 500‐757, KoreaSchool of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T.</namePart><namePart type="family">Onaga</namePart><affiliation>School of Veterinary Medicine, Chonnam National University, Kwang‐Ju 500‐757, Korea</affiliation><affiliation>School of Veterinary Medicine, Chonnam National University, Kwang‐Ju 500‐757, KoreaSchool of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Kato</namePart><affiliation>School of Veterinary Medicine, Chonnam National University, Kwang‐Ju 500‐757, Korea</affiliation><affiliation>School of Veterinary Medicine, Chonnam National University, Kwang‐Ju 500‐757, KoreaSchool of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">1997-02-12</dateIssued><edition>April 7, 1997</edition><copyrightDate encoding="w3cdtf">1997</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="references">14</extent></physicalDescription><abstract lang="en">This study was designed to clarify whether PGE2 directly inhibits glucose absorption in villous cells. For this purpose, isolated villous epithelial cells of the ovine small intestine were used, and the uptake of 14C‐labelled glucose in the absorptive epithelial cells was measured in the presence and absence of 0.2 mM phlorizin or 10 μM PGE2. In isolated villous epithelial cells of the small intestine in sheep, net glucose absorption was reduced by 68.2% in the presence of phlorizin. This result indicates that most of the glucose in ruminants is absorbed by the specific transporter SGLT1, which is sensitive to phlorizin. PGE2 decreased glucose absorption by 26.5% in isolated villous epithelial cells in sheep, although this glucose absorption did not change in the presence of phlorizin. This result clearly indicates the PGE2 inhibits the phlorizin‐sensitive glucose absorptive process through direct action on the villous cells of ruminants.</abstract><relatedItem type="host"><titleInfo><title>Journal of Veterinary Medicine Series A</title></titleInfo><genre type="Journal">journal</genre><identifier type="ISSN">0931-184X</identifier><identifier type="eISSN">1439-0442</identifier><identifier type="DOI">10.1111/(ISSN)1439-0442</identifier><identifier type="PublisherID">TBED</identifier><part><date>1997</date><detail type="volume"><caption>vol.</caption><number>44</number></detail><detail type="issue"><caption>no.</caption><number>1‐10</number></detail><extent unit="pages"><start>443</start><end>447</end><total>5</total></extent></part></relatedItem><identifier type="istex">C87D8ACC182BCC9027A088A6F89612E36AF44A5B</identifier><identifier type="DOI">10.1111/j.1439-0442.1997.tb01129.x</identifier><identifier type="ArticleID">TBED1129</identifier><accessCondition type="use and reproduction" contentType="copyright">© 1997 Blackwell Verlag GmbH</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Blackwell Publishing Ltd</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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