Cross-reactions of Ia antigens between mouse and man
Identifieur interne : 002B20 ( Istex/Corpus ); précédent : 002B19; suivant : 002B21Cross-reactions of Ia antigens between mouse and man
Auteurs : H. A. Vaughan ; M. S. Sandrin ; I. F. C. Mckenzie ; B. D. Tait ; A. TingSource :
- Human Immunology [ 0198-8859 ] ; 1981.
Abstract
Murine alloantisera with specificity for the I-region of the MHC were found to cross-react with human B lymphocytes. By using antisera selected for subregion specificity and including monoclonal antibodies, antisera directed to I-E/Ck products were shown to have the greatest cross-reactivity with human cells. In the reciprocal direction, human anti-DRw alloantisera were also found to contain antibodies that reacted with murine B lymphocytes and by using congenic strains this reaction was shown to be MHC restricted and was of the “Ia type.” By studying appropriate intra-H-2 recombinant strains, the reactivity could be mapped to the I-E subregion (especially to I-Ek). In addition, antibodies to the murine I-Ek subregion could specifically block the reaction of the two DRw antisera examined; whereas, anti-I-Ak antisera were without effect. These studies further highlight the unique cross-reactions between two highly polymorphic gene products in mouse and man, and demonstrate that the I-E
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DOI: 10.1016/0198-8859(81)90058-6
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<front><div type="abstract" xml:lang="en">Murine alloantisera with specificity for the I-region of the MHC were found to cross-react with human B lymphocytes. By using antisera selected for subregion specificity and including monoclonal antibodies, antisera directed to I-E/Ck products were shown to have the greatest cross-reactivity with human cells. In the reciprocal direction, human anti-DRw alloantisera were also found to contain antibodies that reacted with murine B lymphocytes and by using congenic strains this reaction was shown to be MHC restricted and was of the “Ia type.” By studying appropriate intra-H-2 recombinant strains, the reactivity could be mapped to the I-E subregion (especially to I-Ek). In addition, antibodies to the murine I-Ek subregion could specifically block the reaction of the two DRw antisera examined; whereas, anti-I-Ak antisera were without effect. These studies further highlight the unique cross-reactions between two highly polymorphic gene products in mouse and man, and demonstrate that the I-E</div>
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<abstract xml:lang="en"><p>Murine alloantisera with specificity for the I-region of the MHC were found to cross-react with human B lymphocytes. By using antisera selected for subregion specificity and including monoclonal antibodies, antisera directed to I-E/Ck products were shown to have the greatest cross-reactivity with human cells. In the reciprocal direction, human anti-DRw alloantisera were also found to contain antibodies that reacted with murine B lymphocytes and by using congenic strains this reaction was shown to be MHC restricted and was of the “Ia type.” By studying appropriate intra-H-2 recombinant strains, the reactivity could be mapped to the I-E subregion (especially to I-Ek). In addition, antibodies to the murine I-Ek subregion could specifically block the reaction of the two DRw antisera examined; whereas, anti-I-Ak antisera were without effect. These studies further highlight the unique cross-reactions between two highly polymorphic gene products in mouse and man, and demonstrate that the I-E</p>
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<head><ce:title>Cross-reactions of Ia antigens between mouse and man</ce:title>
<ce:author-group><ce:author><ce:given-name>H.A.</ce:given-name>
<ce:surname>Vaughan</ce:surname>
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<ce:author><ce:given-name>M.S.</ce:given-name>
<ce:surname>Sandrin</ce:surname>
<ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup>
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<ce:author><ce:given-name>I.F.C.</ce:given-name>
<ce:surname>McKenzie</ce:surname>
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<ce:cross-ref refid="COR1">*</ce:cross-ref>
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<ce:author><ce:given-name>B.D.</ce:given-name>
<ce:surname>Tait</ce:surname>
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<ce:author><ce:given-name>A.</ce:given-name>
<ce:surname>Ting</ce:surname>
<ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup>
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<ce:textfn>Nuffield Department of Surgery, John Radcliffe Hospital, Oxford, England</ce:textfn>
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<ce:text>Address requests for reprints to Dr. I.F.C. McKenzie, Department of Medicine, Austin Hospital, Heidelberg, 3084, Victoria, Australia</ce:text>
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<ce:abstract><ce:section-title>Abstract</ce:section-title>
<ce:abstract-sec><ce:simple-para>Murine alloantisera with specificity for the I-region of the MHC were found to cross-react with human B lymphocytes. By using antisera selected for subregion specificity and including monoclonal antibodies, antisera directed to I-E/C<ce:sup>k</ce:sup>
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subregion could specifically block the reaction of the two DRw antisera examined; whereas, anti-I-A<ce:sup>k</ce:sup>
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<name type="personal"><namePart type="given">H.A.</namePart>
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<affiliation>Department of Medicine, Austin Hospital, Heidelberg, Victoria, Australia</affiliation>
<affiliation>Tissue Typing Laboratory, Royal Melbourne Hospital, Parkville, Victoria, Australia</affiliation>
<affiliation>Nuffield Department of Surgery, John Radcliffe Hospital, Oxford, England</affiliation>
<role><roleTerm type="text">author</roleTerm>
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</name>
<name type="personal"><namePart type="given">M.S.</namePart>
<namePart type="family">Sandrin</namePart>
<affiliation>Department of Medicine, Austin Hospital, Heidelberg, Victoria, Australia</affiliation>
<affiliation>Tissue Typing Laboratory, Royal Melbourne Hospital, Parkville, Victoria, Australia</affiliation>
<affiliation>Nuffield Department of Surgery, John Radcliffe Hospital, Oxford, England</affiliation>
<role><roleTerm type="text">author</roleTerm>
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</name>
<name type="personal"><namePart type="given">I.F.C.</namePart>
<namePart type="family">McKenzie</namePart>
<affiliation>Department of Medicine, Austin Hospital, Heidelberg, Victoria, Australia</affiliation>
<affiliation>Tissue Typing Laboratory, Royal Melbourne Hospital, Parkville, Victoria, Australia</affiliation>
<affiliation>Nuffield Department of Surgery, John Radcliffe Hospital, Oxford, England</affiliation>
<affiliation>Address requests for reprints to Dr. I.F.C. McKenzie, Department of Medicine, Austin Hospital, Heidelberg, 3084, Victoria, Australia</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">B.D.</namePart>
<namePart type="family">Tait</namePart>
<affiliation>Department of Medicine, Austin Hospital, Heidelberg, Victoria, Australia</affiliation>
<affiliation>Tissue Typing Laboratory, Royal Melbourne Hospital, Parkville, Victoria, Australia</affiliation>
<affiliation>Nuffield Department of Surgery, John Radcliffe Hospital, Oxford, England</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">A.</namePart>
<namePart type="family">Ting</namePart>
<affiliation>Department of Medicine, Austin Hospital, Heidelberg, Victoria, Australia</affiliation>
<affiliation>Tissue Typing Laboratory, Royal Melbourne Hospital, Parkville, Victoria, Australia</affiliation>
<affiliation>Nuffield Department of Surgery, John Radcliffe Hospital, Oxford, England</affiliation>
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<originInfo><publisher>ELSEVIER</publisher>
<dateIssued encoding="w3cdtf">1981</dateIssued>
<copyrightDate encoding="w3cdtf">1981</copyrightDate>
</originInfo>
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<languageTerm type="code" authority="rfc3066">en</languageTerm>
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<abstract lang="en">Murine alloantisera with specificity for the I-region of the MHC were found to cross-react with human B lymphocytes. By using antisera selected for subregion specificity and including monoclonal antibodies, antisera directed to I-E/Ck products were shown to have the greatest cross-reactivity with human cells. In the reciprocal direction, human anti-DRw alloantisera were also found to contain antibodies that reacted with murine B lymphocytes and by using congenic strains this reaction was shown to be MHC restricted and was of the “Ia type.” By studying appropriate intra-H-2 recombinant strains, the reactivity could be mapped to the I-E subregion (especially to I-Ek). In addition, antibodies to the murine I-Ek subregion could specifically block the reaction of the two DRw antisera examined; whereas, anti-I-Ak antisera were without effect. These studies further highlight the unique cross-reactions between two highly polymorphic gene products in mouse and man, and demonstrate that the I-E</abstract>
<relatedItem type="host"><titleInfo><title>Human Immunology</title>
</titleInfo>
<titleInfo type="abbreviated"><title>HIM</title>
</titleInfo>
<genre type="Journal">journal</genre>
<originInfo><dateIssued encoding="w3cdtf">198103</dateIssued>
</originInfo>
<identifier type="ISSN">0198-8859</identifier>
<identifier type="PII">S0198-8859(00)X0144-9</identifier>
<part><date>198103</date>
<detail type="volume"><number>2</number>
<caption>vol.</caption>
</detail>
<detail type="issue"><number>2</number>
<caption>no.</caption>
</detail>
<extent unit="issue pages"><start>91</start>
<end>184</end>
</extent>
<extent unit="pages"><start>113</start>
<end>123</end>
</extent>
</part>
</relatedItem>
<identifier type="istex">BDD8B86C8455738B7AF95E3180CAD02C92A045AE</identifier>
<identifier type="DOI">10.1016/0198-8859(81)90058-6</identifier>
<identifier type="PII">0198-8859(81)90058-6</identifier>
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