Cross-reactions of Ia antigens between mouse and man
Identifieur interne : 002B20 ( Istex/Corpus ); précédent : 002B19; suivant : 002B21Cross-reactions of Ia antigens between mouse and man
Auteurs : H. A. Vaughan ; M. S. Sandrin ; I. F. C. Mckenzie ; B. D. Tait ; A. TingSource :
- Human Immunology [ 0198-8859 ] ; 1981.
Abstract
Murine alloantisera with specificity for the I-region of the MHC were found to cross-react with human B lymphocytes. By using antisera selected for subregion specificity and including monoclonal antibodies, antisera directed to I-E/Ck products were shown to have the greatest cross-reactivity with human cells. In the reciprocal direction, human anti-DRw alloantisera were also found to contain antibodies that reacted with murine B lymphocytes and by using congenic strains this reaction was shown to be MHC restricted and was of the “Ia type.” By studying appropriate intra-H-2 recombinant strains, the reactivity could be mapped to the I-E subregion (especially to I-Ek). In addition, antibodies to the murine I-Ek subregion could specifically block the reaction of the two DRw antisera examined; whereas, anti-I-Ak antisera were without effect. These studies further highlight the unique cross-reactions between two highly polymorphic gene products in mouse and man, and demonstrate that the I-E
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DOI: 10.1016/0198-8859(81)90058-6
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Cross-reactions of Ia antigens between mouse and man</title><author><name sortKey="Vaughan, H A" sort="Vaughan, H A" uniqKey="Vaughan H" first="H. A." last="Vaughan">H. A. Vaughan</name><affiliation><mods:affiliation>Department of Medicine, Austin Hospital, Heidelberg, Victoria, Australia</mods:affiliation></affiliation><affiliation><mods:affiliation>Tissue Typing Laboratory, Royal Melbourne Hospital, Parkville, Victoria, Australia</mods:affiliation></affiliation><affiliation><mods:affiliation>Nuffield Department of Surgery, John Radcliffe Hospital, Oxford, England</mods:affiliation></affiliation></author><author><name sortKey="Sandrin, M S" sort="Sandrin, M S" uniqKey="Sandrin M" first="M. S." last="Sandrin">M. S. Sandrin</name><affiliation><mods:affiliation>Department of Medicine, Austin Hospital, Heidelberg, Victoria, Australia</mods:affiliation></affiliation><affiliation><mods:affiliation>Tissue Typing Laboratory, Royal Melbourne Hospital, Parkville, Victoria, Australia</mods:affiliation></affiliation><affiliation><mods:affiliation>Nuffield Department of Surgery, John Radcliffe Hospital, Oxford, England</mods:affiliation></affiliation></author><author><name sortKey="Mckenzie, I F C" sort="Mckenzie, I F C" uniqKey="Mckenzie I" first="I. F. C." last="Mckenzie">I. F. C. Mckenzie</name><affiliation><mods:affiliation>Department of Medicine, Austin Hospital, Heidelberg, Victoria, Australia</mods:affiliation></affiliation><affiliation><mods:affiliation>Tissue Typing Laboratory, Royal Melbourne Hospital, Parkville, Victoria, Australia</mods:affiliation></affiliation><affiliation><mods:affiliation>Nuffield Department of Surgery, John Radcliffe Hospital, Oxford, England</mods:affiliation></affiliation><affiliation><mods:affiliation>Address requests for reprints to Dr. I.F.C. McKenzie, Department of Medicine, Austin Hospital, Heidelberg, 3084, Victoria, Australia</mods:affiliation></affiliation></author><author><name sortKey="Tait, B D" sort="Tait, B D" uniqKey="Tait B" first="B. D." last="Tait">B. D. 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Sandrin</name><affiliation><mods:affiliation>Department of Medicine, Austin Hospital, Heidelberg, Victoria, Australia</mods:affiliation></affiliation><affiliation><mods:affiliation>Tissue Typing Laboratory, Royal Melbourne Hospital, Parkville, Victoria, Australia</mods:affiliation></affiliation><affiliation><mods:affiliation>Nuffield Department of Surgery, John Radcliffe Hospital, Oxford, England</mods:affiliation></affiliation></author><author><name sortKey="Mckenzie, I F C" sort="Mckenzie, I F C" uniqKey="Mckenzie I" first="I. F. C." last="Mckenzie">I. F. C. Mckenzie</name><affiliation><mods:affiliation>Department of Medicine, Austin Hospital, Heidelberg, Victoria, Australia</mods:affiliation></affiliation><affiliation><mods:affiliation>Tissue Typing Laboratory, Royal Melbourne Hospital, Parkville, Victoria, Australia</mods:affiliation></affiliation><affiliation><mods:affiliation>Nuffield Department of Surgery, John Radcliffe Hospital, Oxford, England</mods:affiliation></affiliation><affiliation><mods:affiliation>Address requests for reprints to Dr. I.F.C. McKenzie, Department of Medicine, Austin Hospital, Heidelberg, 3084, Victoria, Australia</mods:affiliation></affiliation></author><author><name sortKey="Tait, B D" sort="Tait, B D" uniqKey="Tait B" first="B. D." last="Tait">B. D. Tait</name><affiliation><mods:affiliation>Department of Medicine, Austin Hospital, Heidelberg, Victoria, Australia</mods:affiliation></affiliation><affiliation><mods:affiliation>Tissue Typing Laboratory, Royal Melbourne Hospital, Parkville, Victoria, Australia</mods:affiliation></affiliation><affiliation><mods:affiliation>Nuffield Department of Surgery, John Radcliffe Hospital, Oxford, England</mods:affiliation></affiliation></author><author><name sortKey="Ting, A" sort="Ting, A" uniqKey="Ting A" first="A." last="Ting">A. Ting</name><affiliation><mods:affiliation>Department of Medicine, Austin Hospital, Heidelberg, Victoria, Australia</mods:affiliation></affiliation><affiliation><mods:affiliation>Tissue Typing Laboratory, Royal Melbourne Hospital, Parkville, Victoria, Australia</mods:affiliation></affiliation><affiliation><mods:affiliation>Nuffield Department of Surgery, John Radcliffe Hospital, Oxford, England</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Human Immunology</title><title level="j" type="abbrev">HIM</title><idno type="ISSN">0198-8859</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1981">1981</date><biblScope unit="volume">2</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="113">113</biblScope><biblScope unit="page" to="123">123</biblScope></imprint><idno type="ISSN">0198-8859</idno></series><idno type="istex">BDD8B86C8455738B7AF95E3180CAD02C92A045AE</idno><idno type="DOI">10.1016/0198-8859(81)90058-6</idno><idno type="PII">0198-8859(81)90058-6</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0198-8859</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Murine alloantisera with specificity for the I-region of the MHC were found to cross-react with human B lymphocytes. By using antisera selected for subregion specificity and including monoclonal antibodies, antisera directed to I-E/Ck products were shown to have the greatest cross-reactivity with human cells. In the reciprocal direction, human anti-DRw alloantisera were also found to contain antibodies that reacted with murine B lymphocytes and by using congenic strains this reaction was shown to be MHC restricted and was of the “Ia type.” By studying appropriate intra-H-2 recombinant strains, the reactivity could be mapped to the I-E subregion (especially to I-Ek). In addition, antibodies to the murine I-Ek subregion could specifically block the reaction of the two DRw antisera examined; whereas, anti-I-Ak antisera were without effect. These studies further highlight the unique cross-reactions between two highly polymorphic gene products in mouse and man, and demonstrate that the I-E</div></front></TEI><istex><corpusName>elsevier</corpusName><author><json:item><name>H.A. Vaughan</name><affiliations><json:string>Department of Medicine, Austin Hospital, Heidelberg, Victoria, Australia</json:string><json:string>Tissue Typing Laboratory, Royal Melbourne Hospital, Parkville, Victoria, Australia</json:string><json:string>Nuffield Department of Surgery, John Radcliffe Hospital, Oxford, England</json:string></affiliations></json:item><json:item><name>M.S. Sandrin</name><affiliations><json:string>Department of Medicine, Austin Hospital, Heidelberg, Victoria, Australia</json:string><json:string>Tissue Typing Laboratory, Royal Melbourne Hospital, Parkville, Victoria, Australia</json:string><json:string>Nuffield Department of Surgery, John Radcliffe Hospital, Oxford, England</json:string></affiliations></json:item><json:item><name>I.F.C. McKenzie</name><affiliations><json:string>Department of Medicine, Austin Hospital, Heidelberg, Victoria, Australia</json:string><json:string>Tissue Typing Laboratory, Royal Melbourne Hospital, Parkville, Victoria, Australia</json:string><json:string>Nuffield Department of Surgery, John Radcliffe Hospital, Oxford, England</json:string><json:string>Address requests for reprints to Dr. I.F.C. McKenzie, Department of Medicine, Austin Hospital, Heidelberg, 3084, Victoria, Australia</json:string></affiliations></json:item><json:item><name>B.D. Tait</name><affiliations><json:string>Department of Medicine, Austin Hospital, Heidelberg, Victoria, Australia</json:string><json:string>Tissue Typing Laboratory, Royal Melbourne Hospital, Parkville, Victoria, Australia</json:string><json:string>Nuffield Department of Surgery, John Radcliffe Hospital, Oxford, England</json:string></affiliations></json:item><json:item><name>A. Ting</name><affiliations><json:string>Department of Medicine, Austin Hospital, Heidelberg, Victoria, Australia</json:string><json:string>Tissue Typing Laboratory, Royal Melbourne Hospital, Parkville, Victoria, Australia</json:string><json:string>Nuffield Department of Surgery, John Radcliffe Hospital, Oxford, England</json:string></affiliations></json:item></author><language><json:string>eng</json:string></language><abstract>Murine alloantisera with specificity for the I-region of the MHC were found to cross-react with human B lymphocytes. By using antisera selected for subregion specificity and including monoclonal antibodies, antisera directed to I-E/Ck products were shown to have the greatest cross-reactivity with human cells. In the reciprocal direction, human anti-DRw alloantisera were also found to contain antibodies that reacted with murine B lymphocytes and by using congenic strains this reaction was shown to be MHC restricted and was of the “Ia type.” By studying appropriate intra-H-2 recombinant strains, the reactivity could be mapped to the I-E subregion (especially to I-Ek). In addition, antibodies to the murine I-Ek subregion could specifically block the reaction of the two DRw antisera examined; whereas, anti-I-Ak antisera were without effect. These studies further highlight the unique cross-reactions between two highly polymorphic gene products in mouse and man, and demonstrate that the I-E</abstract><qualityIndicators><score>5.837</score><pdfVersion>1.2</pdfVersion><pdfPageSize>360 x 504 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>0</keywordCount><abstractCharCount>999</abstractCharCount><pdfWordCount>4073</pdfWordCount><pdfCharCount>23222</pdfCharCount><pdfPageCount>11</pdfPageCount><abstractWordCount>147</abstractWordCount></qualityIndicators><title>Cross-reactions of Ia antigens between mouse and man</title><pii><json:string>0198-8859(81)90058-6</json:string></pii><genre><json:string>research-article</json:string></genre><serie><volume>75</volume><pages><first>3953</first></pages><genre></genre><language><json:string>unknown</json:string></language><title>Proc Natl Acad Sci USA</title></serie><host><volume>2</volume><pii><json:string>S0198-8859(00)X0144-9</json:string></pii><pages><last>123</last><first>113</first></pages><issn><json:string>0198-8859</json:string></issn><issue>2</issue><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><title>Human Immunology</title><publicationDate>1981</publicationDate></host><categories><wos><json:string>IMMUNOLOGY</json:string></wos></categories><publicationDate>1981</publicationDate><copyrightDate>1981</copyrightDate><doi><json:string>10.1016/0198-8859(81)90058-6</json:string></doi><id>BDD8B86C8455738B7AF95E3180CAD02C92A045AE</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/BDD8B86C8455738B7AF95E3180CAD02C92A045AE/fulltext/pdf</uri></json:item><json:item><original>true</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/BDD8B86C8455738B7AF95E3180CAD02C92A045AE/fulltext/txt</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/BDD8B86C8455738B7AF95E3180CAD02C92A045AE/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/BDD8B86C8455738B7AF95E3180CAD02C92A045AE/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a">Cross-reactions of Ia antigens between mouse and man</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>ELSEVIER</publisher><availability><p>ELSEVIER</p></availability><date>1981</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a">Cross-reactions of Ia antigens between mouse and man</title><author><persName><forename type="first">H.A.</forename><surname>Vaughan</surname></persName><affiliation>Department of Medicine, Austin Hospital, Heidelberg, Victoria, Australia</affiliation><affiliation>Tissue Typing Laboratory, Royal Melbourne Hospital, Parkville, Victoria, Australia</affiliation><affiliation>Nuffield Department of Surgery, John Radcliffe Hospital, Oxford, England</affiliation></author><author><persName><forename type="first">M.S.</forename><surname>Sandrin</surname></persName><affiliation>Department of Medicine, Austin Hospital, Heidelberg, Victoria, Australia</affiliation><affiliation>Tissue Typing Laboratory, Royal Melbourne Hospital, Parkville, Victoria, Australia</affiliation><affiliation>Nuffield Department of Surgery, John Radcliffe Hospital, Oxford, England</affiliation></author><author><persName><forename type="first">I.F.C.</forename><surname>McKenzie</surname></persName><affiliation>Department of Medicine, Austin Hospital, Heidelberg, Victoria, Australia</affiliation><affiliation>Tissue Typing Laboratory, Royal Melbourne Hospital, Parkville, Victoria, Australia</affiliation><affiliation>Nuffield Department of Surgery, John Radcliffe Hospital, Oxford, England</affiliation><affiliation>Address requests for reprints to Dr. I.F.C. McKenzie, Department of Medicine, Austin Hospital, Heidelberg, 3084, Victoria, Australia</affiliation></author><author><persName><forename type="first">B.D.</forename><surname>Tait</surname></persName><affiliation>Department of Medicine, Austin Hospital, Heidelberg, Victoria, Australia</affiliation><affiliation>Tissue Typing Laboratory, Royal Melbourne Hospital, Parkville, Victoria, Australia</affiliation><affiliation>Nuffield Department of Surgery, John Radcliffe Hospital, Oxford, England</affiliation></author><author><persName><forename type="first">A.</forename><surname>Ting</surname></persName><affiliation>Department of Medicine, Austin Hospital, Heidelberg, Victoria, Australia</affiliation><affiliation>Tissue Typing Laboratory, Royal Melbourne Hospital, Parkville, Victoria, Australia</affiliation><affiliation>Nuffield Department of Surgery, John Radcliffe Hospital, Oxford, England</affiliation></author></analytic><monogr><title level="j">Human Immunology</title><title level="j" type="abbrev">HIM</title><idno type="pISSN">0198-8859</idno><idno type="PII">S0198-8859(00)X0144-9</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1981"></date><biblScope unit="volume">2</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="113">113</biblScope><biblScope unit="page" to="123">123</biblScope></imprint></monogr><idno type="istex">BDD8B86C8455738B7AF95E3180CAD02C92A045AE</idno><idno type="DOI">10.1016/0198-8859(81)90058-6</idno><idno type="PII">0198-8859(81)90058-6</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1981</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Murine alloantisera with specificity for the I-region of the MHC were found to cross-react with human B lymphocytes. By using antisera selected for subregion specificity and including monoclonal antibodies, antisera directed to I-E/Ck products were shown to have the greatest cross-reactivity with human cells. In the reciprocal direction, human anti-DRw alloantisera were also found to contain antibodies that reacted with murine B lymphocytes and by using congenic strains this reaction was shown to be MHC restricted and was of the “Ia type.” By studying appropriate intra-H-2 recombinant strains, the reactivity could be mapped to the I-E subregion (especially to I-Ek). In addition, antibodies to the murine I-Ek subregion could specifically block the reaction of the two DRw antisera examined; whereas, anti-I-Ak antisera were without effect. These studies further highlight the unique cross-reactions between two highly polymorphic gene products in mouse and man, and demonstrate that the I-E</p></abstract></profileDesc><revisionDesc><change when="1981">Published</change></revisionDesc></teiHeader></istex:fulltextTEI></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla"><item-info><jid>HIM</jid><aid>81900586</aid><ce:pii>0198-8859(81)90058-6</ce:pii><ce:doi>10.1016/0198-8859(81)90058-6</ce:doi><ce:copyright type="unknown" year="1981"></ce:copyright></item-info><head><ce:title>Cross-reactions of Ia antigens between mouse and man</ce:title><ce:author-group><ce:author><ce:given-name>H.A.</ce:given-name><ce:surname>Vaughan</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF2"><ce:sup>b</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF3"><ce:sup>c</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>M.S.</ce:given-name><ce:surname>Sandrin</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF2"><ce:sup>b</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF3"><ce:sup>c</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>I.F.C.</ce:given-name><ce:surname>McKenzie</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF2"><ce:sup>b</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF3"><ce:sup>c</ce:sup></ce:cross-ref><ce:cross-ref refid="COR1">*</ce:cross-ref></ce:author><ce:author><ce:given-name>B.D.</ce:given-name><ce:surname>Tait</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF2"><ce:sup>b</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF3"><ce:sup>c</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>A.</ce:given-name><ce:surname>Ting</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF2"><ce:sup>b</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF3"><ce:sup>c</ce:sup></ce:cross-ref></ce:author><ce:affiliation id="AFF1"><ce:label>a</ce:label><ce:textfn>Department of Medicine, Austin Hospital, Heidelberg, Victoria, Australia</ce:textfn></ce:affiliation><ce:affiliation id="AFF2"><ce:label>b</ce:label><ce:textfn>Tissue Typing Laboratory, Royal Melbourne Hospital, Parkville, Victoria, Australia</ce:textfn></ce:affiliation><ce:affiliation id="AFF3"><ce:label>c</ce:label><ce:textfn>Nuffield Department of Surgery, John Radcliffe Hospital, Oxford, England</ce:textfn></ce:affiliation><ce:correspondence id="COR1"><ce:label>∗</ce:label><ce:text>Address requests for reprints to Dr. I.F.C. McKenzie, Department of Medicine, Austin Hospital, Heidelberg, 3084, Victoria, Australia</ce:text></ce:correspondence></ce:author-group><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>Murine alloantisera with specificity for the I-region of the MHC were found to cross-react with human B lymphocytes. By using antisera selected for subregion specificity and including monoclonal antibodies, antisera directed to I-E/C<ce:sup>k</ce:sup> products were shown to have the greatest cross-reactivity with human cells. In the reciprocal direction, human anti-DRw alloantisera were also found to contain antibodies that reacted with murine B lymphocytes and by using congenic strains this reaction was shown to be MHC restricted and was of the “Ia type.” By studying appropriate intra-H-2 recombinant strains, the reactivity could be mapped to the I-E subregion (especially to I-E<ce:sup>k</ce:sup>). In addition, antibodies to the murine I-E<ce:sup>k</ce:sup> subregion could specifically block the reaction of the two DRw antisera examined; whereas, anti-I-A<ce:sup>k</ce:sup> antisera were without effect. These studies further highlight the unique cross-reactions between two highly polymorphic gene products in mouse and man, and demonstrate that the I-E</ce:simple-para></ce:abstract-sec></ce:abstract></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Cross-reactions of Ia antigens between mouse and man</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Cross-reactions of Ia antigens between mouse and man</title></titleInfo><name type="personal"><namePart type="given">H.A.</namePart><namePart type="family">Vaughan</namePart><affiliation>Department of Medicine, Austin Hospital, Heidelberg, Victoria, Australia</affiliation><affiliation>Tissue Typing Laboratory, Royal Melbourne Hospital, Parkville, Victoria, Australia</affiliation><affiliation>Nuffield Department of Surgery, John Radcliffe Hospital, Oxford, England</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.S.</namePart><namePart type="family">Sandrin</namePart><affiliation>Department of Medicine, Austin Hospital, Heidelberg, Victoria, Australia</affiliation><affiliation>Tissue Typing Laboratory, Royal Melbourne Hospital, Parkville, Victoria, Australia</affiliation><affiliation>Nuffield Department of Surgery, John Radcliffe Hospital, Oxford, England</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I.F.C.</namePart><namePart type="family">McKenzie</namePart><affiliation>Department of Medicine, Austin Hospital, Heidelberg, Victoria, Australia</affiliation><affiliation>Tissue Typing Laboratory, Royal Melbourne Hospital, Parkville, Victoria, Australia</affiliation><affiliation>Nuffield Department of Surgery, John Radcliffe Hospital, Oxford, England</affiliation><affiliation>Address requests for reprints to Dr. I.F.C. McKenzie, Department of Medicine, Austin Hospital, Heidelberg, 3084, Victoria, Australia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B.D.</namePart><namePart type="family">Tait</namePart><affiliation>Department of Medicine, Austin Hospital, Heidelberg, Victoria, Australia</affiliation><affiliation>Tissue Typing Laboratory, Royal Melbourne Hospital, Parkville, Victoria, Australia</affiliation><affiliation>Nuffield Department of Surgery, John Radcliffe Hospital, Oxford, England</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Ting</namePart><affiliation>Department of Medicine, Austin Hospital, Heidelberg, Victoria, Australia</affiliation><affiliation>Tissue Typing Laboratory, Royal Melbourne Hospital, Parkville, Victoria, Australia</affiliation><affiliation>Nuffield Department of Surgery, John Radcliffe Hospital, Oxford, England</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article"></genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1981</dateIssued><copyrightDate encoding="w3cdtf">1981</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">Murine alloantisera with specificity for the I-region of the MHC were found to cross-react with human B lymphocytes. By using antisera selected for subregion specificity and including monoclonal antibodies, antisera directed to I-E/Ck products were shown to have the greatest cross-reactivity with human cells. In the reciprocal direction, human anti-DRw alloantisera were also found to contain antibodies that reacted with murine B lymphocytes and by using congenic strains this reaction was shown to be MHC restricted and was of the “Ia type.” By studying appropriate intra-H-2 recombinant strains, the reactivity could be mapped to the I-E subregion (especially to I-Ek). In addition, antibodies to the murine I-Ek subregion could specifically block the reaction of the two DRw antisera examined; whereas, anti-I-Ak antisera were without effect. These studies further highlight the unique cross-reactions between two highly polymorphic gene products in mouse and man, and demonstrate that the I-E</abstract><relatedItem type="host"><titleInfo><title>Human Immunology</title></titleInfo><titleInfo type="abbreviated"><title>HIM</title></titleInfo><genre type="Journal">journal</genre><originInfo><dateIssued encoding="w3cdtf">198103</dateIssued></originInfo><identifier type="ISSN">0198-8859</identifier><identifier type="PII">S0198-8859(00)X0144-9</identifier><part><date>198103</date><detail type="volume"><number>2</number><caption>vol.</caption></detail><detail type="issue"><number>2</number><caption>no.</caption></detail><extent unit="issue pages"><start>91</start><end>184</end></extent><extent unit="pages"><start>113</start><end>123</end></extent></part></relatedItem><identifier type="istex">BDD8B86C8455738B7AF95E3180CAD02C92A045AE</identifier><identifier type="DOI">10.1016/0198-8859(81)90058-6</identifier><identifier type="PII">0198-8859(81)90058-6</identifier><recordInfo><recordContentSource>ELSEVIER</recordContentSource></recordInfo></mods></metadata><enrichments><istex:catWosTEI uri="https://api.istex.fr/document/BDD8B86C8455738B7AF95E3180CAD02C92A045AE/enrichments/catWos"><teiHeader><profileDesc><textClass><classCode scheme="WOS">IMMUNOLOGY</classCode></textClass></profileDesc></teiHeader></istex:catWosTEI></enrichments></istex></record>Pour manipuler ce document sous Unix (Dilib)
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