A Serum Factor Reacting with Acriflavin Causing an Error in ABO Cell Grouping
Identifieur interne : 002685 ( Istex/Corpus ); précédent : 002684; suivant : 002686A Serum Factor Reacting with Acriflavin Causing an Error in ABO Cell Grouping
Auteurs : K. M. Beattie ; W. W. ZuelzerSource :
- Transfusion [ 0041-1132 ] ; 1968-07-08.
Abstract
The blood of a donor was investigated because of a discrepancy between cell grouping and serum confirmation. Her whole blood reacted strongly with five commercial preparations of anti‐B sera, yet her serum contained normal anti‐B isoagglutinins. Grouping tests with the donor's washed red cells suspended in saline indicated they were group O. Further tests of the donor's whole blood showed that raw high titered anti‐B did not cause agglutination. The addition of acriflavin (the dye used to color commercial preparation of anti‐B) to the donor's blood caused spontaneous agglutination. The donor's serum plus acriflavin caused agglutination of all random group O red cells. Various antibiotics, drugs and vitamins such as riboflavin, cyanocobalamin, tetracycline, penicillin, chloromycetin, mycostatin, gantrisin, streptomycin, phenacetin, atabrine and quinidine did not cause agglutination. The serum, when tested against her own cells or random group O cells in the presence of acriflavin, was reactive at a titer of 1:64; the reaction was not positive by the antiglobulin test. 2‐Mercaptoethanol destroyed the reactivity of the serum. Inasmuch as the reaction was not complement dependent or enzyme affected, the phenomenon of immune adherence was ruled out. One year later her serum was still reactive at a titer of 1:32. No other example of this serum factor was found in 1,000 random hospital patients. An antigen‐antibody reaction comparable to that observed in phenacetin dependent reactions3 is postulated.
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DOI: 10.1111/j.1537-2995.1968.tb02418.x
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Zuelzer</name><affiliation><mods:affiliation>Michigan Community Blood Center and The Child Research Center of Michigan, Detroit, Michigan</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:7E878CDE33F4C44C7D88FC9278E36B33396BA2EE</idno><date when="1968" year="1968">1968</date><idno type="doi">10.1111/j.1537-2995.1968.tb02418.x</idno><idno type="url">https://api.istex.fr/document/7E878CDE33F4C44C7D88FC9278E36B33396BA2EE/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">002685</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">A Serum Factor Reacting with Acriflavin Causing an Error in ABO Cell Grouping</title><author><name sortKey="Beattie, K M" sort="Beattie, K M" uniqKey="Beattie K" first="K. M." last="Beattie">K. M. Beattie</name><affiliation><mods:affiliation>Michigan Community Blood Center and The Child Research Center of Michigan, Detroit, Michigan</mods:affiliation></affiliation></author><author><name sortKey="Zuelzer, W W" sort="Zuelzer, W W" uniqKey="Zuelzer W" first="W. W." last="Zuelzer">W. W. Zuelzer</name><affiliation><mods:affiliation>Michigan Community Blood Center and The Child Research Center of Michigan, Detroit, Michigan</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Transfusion</title><idno type="ISSN">0041-1132</idno><idno type="eISSN">1537-2995</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="1968-07-08">1968-07-08</date><biblScope unit="volume">8</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="254">254</biblScope><biblScope unit="page" to="257">257</biblScope></imprint><idno type="ISSN">0041-1132</idno></series><idno type="istex">7E878CDE33F4C44C7D88FC9278E36B33396BA2EE</idno><idno type="DOI">10.1111/j.1537-2995.1968.tb02418.x</idno><idno type="ArticleID">TRF2418</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0041-1132</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The blood of a donor was investigated because of a discrepancy between cell grouping and serum confirmation. Her whole blood reacted strongly with five commercial preparations of anti‐B sera, yet her serum contained normal anti‐B isoagglutinins. Grouping tests with the donor's washed red cells suspended in saline indicated they were group O. Further tests of the donor's whole blood showed that raw high titered anti‐B did not cause agglutination. The addition of acriflavin (the dye used to color commercial preparation of anti‐B) to the donor's blood caused spontaneous agglutination. The donor's serum plus acriflavin caused agglutination of all random group O red cells. Various antibiotics, drugs and vitamins such as riboflavin, cyanocobalamin, tetracycline, penicillin, chloromycetin, mycostatin, gantrisin, streptomycin, phenacetin, atabrine and quinidine did not cause agglutination. The serum, when tested against her own cells or random group O cells in the presence of acriflavin, was reactive at a titer of 1:64; the reaction was not positive by the antiglobulin test. 2‐Mercaptoethanol destroyed the reactivity of the serum. Inasmuch as the reaction was not complement dependent or enzyme affected, the phenomenon of immune adherence was ruled out. One year later her serum was still reactive at a titer of 1:32. No other example of this serum factor was found in 1,000 random hospital patients. An antigen‐antibody reaction comparable to that observed in phenacetin dependent reactions3 is postulated.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>K. M. Beattie</name><affiliations><json:string>Michigan Community Blood Center and The Child Research Center of Michigan, Detroit, Michigan</json:string></affiliations></json:item><json:item><name>W. W. 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Various antibiotics, drugs and vitamins such as riboflavin, cyanocobalamin, tetracycline, penicillin, chloromycetin, mycostatin, gantrisin, streptomycin, phenacetin, atabrine and quinidine did not cause agglutination. The serum, when tested against her own cells or random group O cells in the presence of acriflavin, was reactive at a titer of 1:64; the reaction was not positive by the antiglobulin test. 2‐Mercaptoethanol destroyed the reactivity of the serum. Inasmuch as the reaction was not complement dependent or enzyme affected, the phenomenon of immune adherence was ruled out. One year later her serum was still reactive at a titer of 1:32. No other example of this serum factor was found in 1,000 random hospital patients. An antigen‐antibody reaction comparable to that observed in phenacetin dependent reactions3 is postulated.</abstract><qualityIndicators><score>4.55</score><pdfVersion>1.3</pdfVersion><pdfPageSize>504 x 720.24 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>0</keywordCount><abstractCharCount>1518</abstractCharCount><pdfWordCount>1838</pdfWordCount><pdfCharCount>11252</pdfCharCount><pdfPageCount>4</pdfPageCount><abstractWordCount>226</abstractWordCount></qualityIndicators><title>A Serum Factor Reacting with Acriflavin Causing an Error in ABO Cell Grouping</title><genre><json:string>article</json:string></genre><host><volume>8</volume><publisherId><json:string>TRF</json:string></publisherId><pages><total>4</total><last>257</last><first>254</first></pages><issn><json:string>0041-1132</json:string></issn><issue>4</issue><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1537-2995</json:string></eissn><title>Transfusion</title><doi><json:string>10.1111/(ISSN)1537-2995</json:string></doi></host><publicationDate>1968</publicationDate><copyrightDate>1968</copyrightDate><doi><json:string>10.1111/j.1537-2995.1968.tb02418.x</json:string></doi><id>7E878CDE33F4C44C7D88FC9278E36B33396BA2EE</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/7E878CDE33F4C44C7D88FC9278E36B33396BA2EE/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/7E878CDE33F4C44C7D88FC9278E36B33396BA2EE/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/7E878CDE33F4C44C7D88FC9278E36B33396BA2EE/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">A Serum Factor Reacting with Acriflavin Causing an Error in ABO Cell Grouping</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><availability><p>WILEY</p></availability><date>1968</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">A Serum Factor Reacting with Acriflavin Causing an Error in ABO Cell Grouping</title><author><persName><forename type="first">K. M.</forename><surname>Beattie</surname></persName><note type="correspondence"><p>Correspondence: Michigan Community Blood Center, 3156 Woodward Avenue, Detroit, Michigan 48201.</p></note><affiliation>Michigan Community Blood Center and The Child Research Center of Michigan, Detroit, Michigan</affiliation></author><author><persName><forename type="first">W. W.</forename><surname>Zuelzer</surname></persName><affiliation>Michigan Community Blood Center and The Child Research Center of Michigan, Detroit, Michigan</affiliation></author></analytic><monogr><title level="j">Transfusion</title><idno type="pISSN">0041-1132</idno><idno type="eISSN">1537-2995</idno><idno type="DOI">10.1111/(ISSN)1537-2995</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="1968-07-08"></date><biblScope unit="volume">8</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="254">254</biblScope><biblScope unit="page" to="257">257</biblScope></imprint></monogr><idno type="istex">7E878CDE33F4C44C7D88FC9278E36B33396BA2EE</idno><idno type="DOI">10.1111/j.1537-2995.1968.tb02418.x</idno><idno type="ArticleID">TRF2418</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1968</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>The blood of a donor was investigated because of a discrepancy between cell grouping and serum confirmation. Her whole blood reacted strongly with five commercial preparations of anti‐B sera, yet her serum contained normal anti‐B isoagglutinins. Grouping tests with the donor's washed red cells suspended in saline indicated they were group O. Further tests of the donor's whole blood showed that raw high titered anti‐B did not cause agglutination. The addition of acriflavin (the dye used to color commercial preparation of anti‐B) to the donor's blood caused spontaneous agglutination. The donor's serum plus acriflavin caused agglutination of all random group O red cells. Various antibiotics, drugs and vitamins such as riboflavin, cyanocobalamin, tetracycline, penicillin, chloromycetin, mycostatin, gantrisin, streptomycin, phenacetin, atabrine and quinidine did not cause agglutination. The serum, when tested against her own cells or random group O cells in the presence of acriflavin, was reactive at a titer of 1:64; the reaction was not positive by the antiglobulin test. 2‐Mercaptoethanol destroyed the reactivity of the serum. Inasmuch as the reaction was not complement dependent or enzyme affected, the phenomenon of immune adherence was ruled out. One year later her serum was still reactive at a titer of 1:32. No other example of this serum factor was found in 1,000 random hospital patients. An antigen‐antibody reaction comparable to that observed in phenacetin dependent reactions3 is postulated.</p></abstract></profileDesc><revisionDesc><change when="1968-07-08">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/7E878CDE33F4C44C7D88FC9278E36B33396BA2EE/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Ltd</publisherName><publisherLoc>Oxford, UK</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1537-2995</doi><issn type="print">0041-1132</issn><issn type="electronic">1537-2995</issn><idGroup><id type="product" value="TRF"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="TRANSFUSION">Transfusion</title></titleGroup></publicationMeta><publicationMeta level="part" position="07004"><doi origin="wiley">10.1111/trf.1968.8.issue-4</doi><numberingGroup><numbering type="journalVolume" number="8">8</numbering><numbering type="journalIssue" number="4">4</numbering></numberingGroup><coverDate startDate="1968-07-08">July‐August 1968</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="8" status="forIssue"><doi origin="wiley">10.1111/j.1537-2995.1968.tb02418.x</doi><idGroup><id type="unit" value="TRF2418"></id></idGroup><countGroup><count type="pageTotal" number="4"></count></countGroup><titleGroup><title type="tocHeading1">Original Article</title></titleGroup><copyright>1968 AABB</copyright><eventGroup><event type="firstOnline" date="2009-10-20"></event><event type="publishedOnlineFinalForm" date="2009-10-20"></event><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.3.6 mode:FullText source:HeaderRef result:HeaderRef" date="2010-04-20"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-10"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-11-04"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="254">254</numbering><numbering type="pageLast" number="257">257</numbering></numberingGroup><correspondenceTo>Michigan Community Blood Center, 3156 Woodward Avenue, Detroit, Michigan 48201.</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:TRF.TRF2418.pdf"></link></linkGroup></publicationMeta><contentMeta><unparsedEditorialHistory>Received for publication January 23, 1968; accepted April 16, 1968.</unparsedEditorialHistory><countGroup><count type="referenceTotal" number="9"></count><count type="linksCrossRef" number="3"></count></countGroup><titleGroup><title type="main">A Serum Factor Reacting with Acriflavin Causing an Error in ABO Cell Grouping</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1" corresponding="yes"><personName><givenNames>K. M.</givenNames><familyName>Beattie</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a1"><personName><givenNames>W. W.</givenNames><familyName>Zuelzer</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1" countryCode="US"><unparsedAffiliation>Michigan Community Blood Center and The Child Research Center of Michigan, Detroit, Michigan</unparsedAffiliation></affiliation></affiliationGroup><abstractGroup><abstract type="main" xml:lang="en"><p>The blood of a donor was investigated because of a discrepancy between cell grouping and serum confirmation. Her whole blood reacted strongly with five commercial preparations of anti‐B sera, yet her serum contained normal anti‐B isoagglutinins. Grouping tests with the donor's washed red cells suspended in saline indicated they were group O. Further tests of the donor's whole blood showed that raw high titered anti‐B did not cause agglutination. The addition of acriflavin (the dye used to color commercial preparation of anti‐B) to the donor's blood caused spontaneous agglutination. The donor's serum plus acriflavin caused agglutination of all random group O red cells. Various antibiotics, drugs and vitamins such as riboflavin, cyanocobalamin, tetracycline, penicillin, chloromycetin, mycostatin, gantrisin, streptomycin, phenacetin, atabrine and quinidine did not cause agglutination.</p><p>The serum, when tested against her own cells or random group O cells in the presence of acriflavin, was reactive at a titer of 1:64; the reaction was not positive by the antiglobulin test. 2‐Mercaptoethanol destroyed the reactivity of the serum. Inasmuch as the reaction was not complement dependent or enzyme affected, the phenomenon of immune adherence was ruled out. One year later her serum was still reactive at a titer of 1:32.</p><p>No other example of this serum factor was found in 1,000 random hospital patients.</p><p>An antigen‐antibody reaction comparable to that observed in phenacetin dependent reactions<sup>3</sup> is postulated.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>A Serum Factor Reacting with Acriflavin Causing an Error in ABO Cell Grouping</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>A Serum Factor Reacting with Acriflavin Causing an Error in ABO Cell Grouping</title></titleInfo><name type="personal"><namePart type="given">K. M.</namePart><namePart type="family">Beattie</namePart><affiliation>Michigan Community Blood Center and The Child Research Center of Michigan, Detroit, Michigan</affiliation><description>Correspondence: Michigan Community Blood Center, 3156 Woodward Avenue, Detroit, Michigan 48201.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W. W.</namePart><namePart type="family">Zuelzer</namePart><affiliation>Michigan Community Blood Center and The Child Research Center of Michigan, Detroit, Michigan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">1968-07-08</dateIssued><edition>Received for publication January 23, 1968; accepted April 16, 1968.</edition><copyrightDate encoding="w3cdtf">1968</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="references">9</extent></physicalDescription><abstract lang="en">The blood of a donor was investigated because of a discrepancy between cell grouping and serum confirmation. Her whole blood reacted strongly with five commercial preparations of anti‐B sera, yet her serum contained normal anti‐B isoagglutinins. Grouping tests with the donor's washed red cells suspended in saline indicated they were group O. Further tests of the donor's whole blood showed that raw high titered anti‐B did not cause agglutination. The addition of acriflavin (the dye used to color commercial preparation of anti‐B) to the donor's blood caused spontaneous agglutination. The donor's serum plus acriflavin caused agglutination of all random group O red cells. Various antibiotics, drugs and vitamins such as riboflavin, cyanocobalamin, tetracycline, penicillin, chloromycetin, mycostatin, gantrisin, streptomycin, phenacetin, atabrine and quinidine did not cause agglutination. The serum, when tested against her own cells or random group O cells in the presence of acriflavin, was reactive at a titer of 1:64; the reaction was not positive by the antiglobulin test. 2‐Mercaptoethanol destroyed the reactivity of the serum. Inasmuch as the reaction was not complement dependent or enzyme affected, the phenomenon of immune adherence was ruled out. One year later her serum was still reactive at a titer of 1:32. No other example of this serum factor was found in 1,000 random hospital patients. An antigen‐antibody reaction comparable to that observed in phenacetin dependent reactions3 is postulated.</abstract><relatedItem type="host"><titleInfo><title>Transfusion</title></titleInfo><genre type="Journal">journal</genre><identifier type="ISSN">0041-1132</identifier><identifier type="eISSN">1537-2995</identifier><identifier type="DOI">10.1111/(ISSN)1537-2995</identifier><identifier type="PublisherID">TRF</identifier><part><date>1968</date><detail type="volume"><caption>vol.</caption><number>8</number></detail><detail type="issue"><caption>no.</caption><number>4</number></detail><extent unit="pages"><start>254</start><end>257</end><total>4</total></extent></part></relatedItem><identifier type="istex">7E878CDE33F4C44C7D88FC9278E36B33396BA2EE</identifier><identifier type="DOI">10.1111/j.1537-2995.1968.tb02418.x</identifier><identifier type="ArticleID">TRF2418</identifier><accessCondition type="use and reproduction" contentType="copyright">1968 AABB</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Blackwell Publishing Ltd</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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