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Aminoterminal propeptide of type III procollagen in methotrexate‐induced liver fibrosis and cirrhosis

Identifieur interne : 002180 ( Istex/Corpus ); précédent : 002179; suivant : 002181

Aminoterminal propeptide of type III procollagen in methotrexate‐induced liver fibrosis and cirrhosis

Auteurs : J. Risteli ; H. S Gaard ; A. Oikarinen ; L. Risteli ; J. Karvonen ; H. Zachariae

Source :

RBID : ISTEX:350F372AD0F42DCE0960A56C8EF60D85E9DF046B

Abstract

Twenty‐four psoriatic patients on methotrexate were studied with liver biopsies and serum measurements of aminoterminal propeptide of type III procollagen (PHI NP). All but one of nine patients with scrum levels of PHI NP above the normal range had liver fibrosis or cirrhosis and no normal liver biopsies were obtained in this group. In contrast, nine normal liver biopsies and two biopsies with minimal fibrosis were found among the 15 patients with normal serum levels of PHI NP. The study indicates that aminoterminal propeptide of type III procollagen can be utilized as a valuable non‐invasive marker of fibrogenesis in the liver. This analysis is not specific for the liver, but it seems that the number of liver biopsies probably can be reduced in psoriatics on methotrexate who have normal levels of PHI NP.

Url:
DOI: 10.1111/j.1365-2133.1988.tb03224.x

Links to Exploration step

ISTEX:350F372AD0F42DCE0960A56C8EF60D85E9DF046B

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<affiliation>Department of Dermatology, Marselisborg Hospital, University of Aarhus, Denmark</affiliation>
<description>Correspondence: Dr H.Zachariae, Department of Dermatology, arselisborg Hospital, DK‐8000 Aarhus C, Denmark.</description>
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<publisher>Blackwell Publishing Ltd</publisher>
<place>
<placeTerm type="text">Oxford, UK</placeTerm>
</place>
<dateIssued encoding="w3cdtf">1988-09</dateIssued>
<edition>Accepted for publication 28 March 1988</edition>
<copyrightDate encoding="w3cdtf">1988</copyrightDate>
</originInfo>
<language>
<languageTerm type="code" authority="rfc3066">en</languageTerm>
<languageTerm type="code" authority="iso639-2b">eng</languageTerm>
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<extent unit="references">12</extent>
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<abstract lang="en">Twenty‐four psoriatic patients on methotrexate were studied with liver biopsies and serum measurements of aminoterminal propeptide of type III procollagen (PHI NP). All but one of nine patients with scrum levels of PHI NP above the normal range had liver fibrosis or cirrhosis and no normal liver biopsies were obtained in this group. In contrast, nine normal liver biopsies and two biopsies with minimal fibrosis were found among the 15 patients with normal serum levels of PHI NP. The study indicates that aminoterminal propeptide of type III procollagen can be utilized as a valuable non‐invasive marker of fibrogenesis in the liver. This analysis is not specific for the liver, but it seems that the number of liver biopsies probably can be reduced in psoriatics on methotrexate who have normal levels of PHI NP.</abstract>
<relatedItem type="host">
<titleInfo>
<title>British Journal of Dermatology</title>
</titleInfo>
<genre type="Journal">journal</genre>
<identifier type="ISSN">0007-0963</identifier>
<identifier type="eISSN">1365-2133</identifier>
<identifier type="DOI">10.1111/(ISSN)1365-2133</identifier>
<identifier type="PublisherID">BJD</identifier>
<part>
<date>1988</date>
<detail type="volume">
<caption>vol.</caption>
<number>119</number>
</detail>
<detail type="issue">
<caption>no.</caption>
<number>3</number>
</detail>
<extent unit="pages">
<start>321</start>
<end>325</end>
<total>5</total>
</extent>
</part>
</relatedItem>
<identifier type="istex">350F372AD0F42DCE0960A56C8EF60D85E9DF046B</identifier>
<identifier type="DOI">10.1111/j.1365-2133.1988.tb03224.x</identifier>
<identifier type="ArticleID">BJD321</identifier>
<recordInfo>
<recordContentSource>WILEY</recordContentSource>
<recordOrigin>Blackwell Publishing Ltd</recordOrigin>
</recordInfo>
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<serie></serie>
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