Complement Levels in Relation to Certain Antibodies in Polytransfused Thalassaemic Patients
Identifieur interne : 002179 ( Istex/Corpus ); précédent : 002178; suivant : 002180Complement Levels in Relation to Certain Antibodies in Polytransfused Thalassaemic Patients
Auteurs : Joanna Economidou ; C. Pathouli ; S. Hadziyannis ; G. Fostiropoulos ; M. ConstantoulakisSource :
- Vox Sanguinis [ 0042-9007 ] ; 1976-12.
Abstract
Abstract. Polytransfused patients are exposed to a variety of antigenic stimuli which may eventually trigger autoimmune reactions. The relation of scrum complement to the occurrence of various antibodies has been investigated in a group of 75 polytransfused thalassaemic patients. The incidence of the antibodies studied was as follows: anti‐HBs 77%, anti‐Gm 64%, rheumatoid factor 31%, antinuclear 13%, anti‐smooth muscle 47%. Anti‐parietal cell, anti‐thyroid and anti‐kidney were only rarely found and antimitochondrial antibodies were never detected. Total hemolytic complement was low in 6 and incidentally decreased in 21 patients. A positive correlation was found between low serum complement and presence of rheumatoid factor. The high incidence of anti‐smooth muscle antibodies seems to be unrelated to liver disease.
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DOI: 10.1111/j.1423-0410.1976.tb02220.x
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<front><div type="abstract" xml:lang="en">Abstract. Polytransfused patients are exposed to a variety of antigenic stimuli which may eventually trigger autoimmune reactions. The relation of scrum complement to the occurrence of various antibodies has been investigated in a group of 75 polytransfused thalassaemic patients. The incidence of the antibodies studied was as follows: anti‐HBs 77%, anti‐Gm 64%, rheumatoid factor 31%, antinuclear 13%, anti‐smooth muscle 47%. Anti‐parietal cell, anti‐thyroid and anti‐kidney were only rarely found and antimitochondrial antibodies were never detected. Total hemolytic complement was low in 6 and incidentally decreased in 21 patients. A positive correlation was found between low serum complement and presence of rheumatoid factor. The high incidence of anti‐smooth muscle antibodies seems to be unrelated to liver disease.</div>
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<abstract lang="en">Abstract. Polytransfused patients are exposed to a variety of antigenic stimuli which may eventually trigger autoimmune reactions. The relation of scrum complement to the occurrence of various antibodies has been investigated in a group of 75 polytransfused thalassaemic patients. The incidence of the antibodies studied was as follows: anti‐HBs 77%, anti‐Gm 64%, rheumatoid factor 31%, antinuclear 13%, anti‐smooth muscle 47%. Anti‐parietal cell, anti‐thyroid and anti‐kidney were only rarely found and antimitochondrial antibodies were never detected. Total hemolytic complement was low in 6 and incidentally decreased in 21 patients. A positive correlation was found between low serum complement and presence of rheumatoid factor. The high incidence of anti‐smooth muscle antibodies seems to be unrelated to liver disease.</abstract>
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