Low IgG4 concentrations in infants with Haemophilus influenzae type b infections
Identifieur interne : 001687 ( Istex/Corpus ); précédent : 001686; suivant : 001688Low IgG4 concentrations in infants with Haemophilus influenzae type b infections
Auteurs : L. J. Beard ; J. F. Hagedorn ; A. FerranteSource :
- Pediatric Allergy and Immunology [ 0905-6157 ] ; 1993-02.
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Abstract
Haemophilus influenzae type b causes considerable morbidity and mortality in infants and young children. Immunity to this organism has been attributed in part to the formation, and increase with age, of antibodies to the capsular polysaccharide of the bacteria. A degree of immunodeficiency could explain why some infants and young children develop invasive haemophilus disease. In this study we investigated immunocom‐petence in ten infants with invasive haemophilus disease. We found normal lymphocyte mitogen responses, neutrophil iodination and bactericidal and fungicidal capacities in this group. While we found no deficiencies of any of the immunoglobulin classes, three patients had low concentrations of IgG4 and two of them had low concentrations of IgG2 as well. These findings suggest that in some infants who develop haemophilus infections, the measurement of IgG subclasses may reveal immune defects that would not otherwise be apparent.
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DOI: 10.1111/j.1399-3038.1993.tb00056.x
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Immunity to this organism has been attributed in part to the formation, and increase with age, of antibodies to the capsular polysaccharide of the bacteria. A degree of immunodeficiency could explain why some infants and young children develop invasive haemophilus disease. In this study we investigated immunocom‐petence in ten infants with invasive haemophilus disease. We found normal lymphocyte mitogen responses, neutrophil iodination and bactericidal and fungicidal capacities in this group. While we found no deficiencies of any of the immunoglobulin classes, three patients had low concentrations of IgG4 and two of them had low concentrations of IgG2 as well. These findings suggest that in some infants who develop haemophilus infections, the measurement of IgG subclasses may reveal immune defects that would not otherwise be apparent.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>L. J. 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J.</forename><surname>Beard</surname></persName><note type="correspondence"><p>Correspondence: L. J. Beard, University Department of Paediatrics, Adelaide Children's Hospital, North Adelaide, South Australia 5006.</p></note><affiliation>Department of Paediatrics, University of Adelaide, Australia.</affiliation><affiliation>Department of Immunology, Adelaide Children's Hospital, Australia.</affiliation></author><author><persName><forename type="first">J. 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Immunity to this organism has been attributed in part to the formation, and increase with age, of antibodies to the capsular polysaccharide of the bacteria. A degree of immunodeficiency could explain why some infants and young children develop invasive haemophilus disease. In this study we investigated immunocom‐petence in ten infants with invasive haemophilus disease. We found normal lymphocyte mitogen responses, neutrophil iodination and bactericidal and fungicidal capacities in this group. While we found no deficiencies of any of the immunoglobulin classes, three patients had low concentrations of IgG4 and two of them had low concentrations of IgG2 as well. 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J. Beard, University Department of Paediatrics, Adelaide Children's Hospital, North Adelaide, South Australia 5006.</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:PAI.PAI1.pdf"></link></linkGroup></publicationMeta><contentMeta><unparsedEditorialHistory>Received March 25, 1992 Accepted September 10, 1992</unparsedEditorialHistory><countGroup><count type="referenceTotal" number="33"></count><count type="linksCrossRef" number="6"></count></countGroup><titleGroup><title type="main">Low IgG4 concentrations in infants with <i>Haemophilus influenzae</i> type b infections</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1 #a2" corresponding="yes"><personName><givenNames>L. J.</givenNames><familyName>Beard</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a2"><personName><givenNames>J. F.</givenNames><familyName>Hagedorn</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a1 #a2"><personName><givenNames>A.</givenNames><familyName>Ferrante</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1" countryCode="AU"><unparsedAffiliation>Department of Paediatrics, University of Adelaide, Australia.</unparsedAffiliation></affiliation><affiliation xml:id="a2" countryCode="AU"><unparsedAffiliation>Department of Immunology, Adelaide Children's Hospital, Australia.</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1">IgG subclasses</keyword><keyword xml:id="k2"><i>H. influenzae</i></keyword><keyword xml:id="k3">meningitis</keyword><keyword xml:id="k4">IgG4 deficiency</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><p> <i>Haemophilus influenzae</i> type b causes considerable morbidity and mortality in infants and young children. Immunity to this organism has been attributed in part to the formation, and increase with age, of antibodies to the capsular polysaccharide of the bacteria. A degree of immunodeficiency could explain why some infants and young children develop invasive haemophilus disease. In this study we investigated immunocom‐petence in ten infants with invasive haemophilus disease. We found normal lymphocyte mitogen responses, neutrophil iodination and bactericidal and fungicidal capacities in this group. While we found no deficiencies of any of the immunoglobulin classes, three patients had low concentrations of IgG4 and two of them had low concentrations of IgG2 as well. These findings suggest that in some infants who develop haemophilus infections, the measurement of IgG subclasses may reveal immune defects that would not otherwise be apparent.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Low IgG4 concentrations in infants with Haemophilus influenzae type b infections</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Low IgG4 concentrations in infants with</title></titleInfo><name type="personal"><namePart type="given">L. J.</namePart><namePart type="family">Beard</namePart><affiliation>Department of Paediatrics, University of Adelaide, Australia.</affiliation><affiliation>Department of Immunology, Adelaide Children's Hospital, Australia.</affiliation><description>Correspondence: L. J. Beard, University Department of Paediatrics, Adelaide Children's Hospital, North Adelaide, South Australia 5006.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. F.</namePart><namePart type="family">Hagedorn</namePart><affiliation>Department of Immunology, Adelaide Children's Hospital, Australia.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Ferrante</namePart><affiliation>Department of Paediatrics, University of Adelaide, Australia.</affiliation><affiliation>Department of Immunology, Adelaide Children's Hospital, Australia.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">1993-02</dateIssued><edition>Received March 25, 1992 Accepted September 10, 1992</edition><copyrightDate encoding="w3cdtf">1993</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="references">33</extent></physicalDescription><abstract lang="en">Haemophilus influenzae type b causes considerable morbidity and mortality in infants and young children. Immunity to this organism has been attributed in part to the formation, and increase with age, of antibodies to the capsular polysaccharide of the bacteria. A degree of immunodeficiency could explain why some infants and young children develop invasive haemophilus disease. In this study we investigated immunocom‐petence in ten infants with invasive haemophilus disease. We found normal lymphocyte mitogen responses, neutrophil iodination and bactericidal and fungicidal capacities in this group. While we found no deficiencies of any of the immunoglobulin classes, three patients had low concentrations of IgG4 and two of them had low concentrations of IgG2 as well. These findings suggest that in some infants who develop haemophilus infections, the measurement of IgG subclasses may reveal immune defects that would not otherwise be apparent.</abstract><subject lang="en"><genre>Keywords</genre><topic>IgG subclasses</topic><topic>H. influenzae</topic><topic>meningitis</topic><topic>IgG4 deficiency</topic></subject><relatedItem type="host"><titleInfo><title>Pediatric Allergy and Immunology</title></titleInfo><genre type="Journal">journal</genre><identifier type="ISSN">0905-6157</identifier><identifier type="eISSN">1399-3038</identifier><identifier type="DOI">10.1111/(ISSN)1399-3038</identifier><identifier type="PublisherID">PAI</identifier><part><date>1993</date><detail type="volume"><caption>vol.</caption><number>4</number></detail><detail type="issue"><caption>no.</caption><number>1</number></detail><extent unit="pages"><start>1</start><end>5</end><total>5</total></extent></part></relatedItem><identifier type="istex">CB7F2E528925B2C796224254FD17A276F88EF0A6</identifier><identifier type="DOI">10.1111/j.1399-3038.1993.tb00056.x</identifier><identifier type="ArticleID">PAI1</identifier><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Blackwell Publishing Ltd</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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