Schistosoma mansoni: Complement-mediated cytotoxic activity in vitro and effect of decomplementation on acquired immunity in mice
Identifieur interne : 000E52 ( Istex/Corpus ); précédent : 000E51; suivant : 000E53Schistosoma mansoni: Complement-mediated cytotoxic activity in vitro and effect of decomplementation on acquired immunity in mice
Auteurs : C. A. P. Tavares ; G. Gazzinelli ; T. A. Mota-Santos ; W. Dias Da SilvaSource :
- Experimental Parasitology [ 0014-4894 ] ; 1978.
Abstract
In this study of the role of the complement system in immunity to schistosomiasis, artificially transformed Schistosoma mansoni, schistosomula were treated with serum from mice with concomitant immunity as a source of antibody (Ab) and with fresh guinea pig serum as a source of complement. Two populations of schistosomula were identifiable. Some were susceptible to the action of complement alone while others were killed only in the presence of antibody and complement. Heated and zymosan treated guinea pig sera were inactive as a source of complement. Guinea pig serum deficient in the fourth component of complement could be used as a source of complement, but it was less effective than normal guinea pig serum. An effect of the complement system in vivo was also observed. Several groups of mice with concomitant immunity were challenged with 270 to 350 cercariae of S. mansoni. Five days later schistosomula were recovered from their lungs and counted. Recovery of worms was significantly increased (P < 0.05) in two out of three experiments in groups of animals which had been pretreated with cobra venom factor to deplete the third component of complement. These results strongly suggest that the complement system is one of the effector mechanisms in concomitant immunity in schistosomiasis.
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DOI: 10.1016/0014-4894(78)90126-1
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Schistosoma mansoni: Complement-mediated cytotoxic activity in vitro and effect of decomplementation on acquired immunity in mice</title><author><name sortKey="Tavares, C A P" sort="Tavares, C A P" uniqKey="Tavares C" first="C. A. P." last="Tavares">C. A. P. Tavares</name><affiliation><mods:affiliation>Departamento de Bioquímica-Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, CP 2486, 30.000 Belo Horizonte, Minas Gerais, Brazil</mods:affiliation></affiliation></author><author><name sortKey="Gazzinelli, G" sort="Gazzinelli, G" uniqKey="Gazzinelli G" first="G." last="Gazzinelli">G. Gazzinelli</name><affiliation><mods:affiliation>Departamento de Bioquímica-Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, CP 2486, 30.000 Belo Horizonte, Minas Gerais, Brazil</mods:affiliation></affiliation></author><author><name sortKey="Mota Santos, T A" sort="Mota Santos, T A" uniqKey="Mota Santos T" first="T. A." last="Mota-Santos">T. A. Mota-Santos</name><affiliation><mods:affiliation>Departamento de Bioquímica-Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, CP 2486, 30.000 Belo Horizonte, Minas Gerais, Brazil</mods:affiliation></affiliation></author><author><name sortKey="Da Silva, W Dias" sort="Da Silva, W Dias" uniqKey="Da Silva W" first="W. Dias" last="Da Silva">W. Dias Da Silva</name><affiliation><mods:affiliation>Departamento de Bioquímica-Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, CP 2486, 30.000 Belo Horizonte, Minas Gerais, Brazil</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:ED40CDF5D40B35D6E74AD28118085E682BFE75E6</idno><date when="1978" year="1978">1978</date><idno type="doi">10.1016/0014-4894(78)90126-1</idno><idno type="url">https://api.istex.fr/document/ED40CDF5D40B35D6E74AD28118085E682BFE75E6/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000E52</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Schistosoma mansoni: Complement-mediated cytotoxic activity in vitro and effect of decomplementation on acquired immunity in mice</title><author><name sortKey="Tavares, C A P" sort="Tavares, C A P" uniqKey="Tavares C" first="C. A. P." last="Tavares">C. A. P. Tavares</name><affiliation><mods:affiliation>Departamento de Bioquímica-Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, CP 2486, 30.000 Belo Horizonte, Minas Gerais, Brazil</mods:affiliation></affiliation></author><author><name sortKey="Gazzinelli, G" sort="Gazzinelli, G" uniqKey="Gazzinelli G" first="G." last="Gazzinelli">G. Gazzinelli</name><affiliation><mods:affiliation>Departamento de Bioquímica-Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, CP 2486, 30.000 Belo Horizonte, Minas Gerais, Brazil</mods:affiliation></affiliation></author><author><name sortKey="Mota Santos, T A" sort="Mota Santos, T A" uniqKey="Mota Santos T" first="T. A." last="Mota-Santos">T. A. Mota-Santos</name><affiliation><mods:affiliation>Departamento de Bioquímica-Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, CP 2486, 30.000 Belo Horizonte, Minas Gerais, Brazil</mods:affiliation></affiliation></author><author><name sortKey="Da Silva, W Dias" sort="Da Silva, W Dias" uniqKey="Da Silva W" first="W. Dias" last="Da Silva">W. Dias Da Silva</name><affiliation><mods:affiliation>Departamento de Bioquímica-Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, CP 2486, 30.000 Belo Horizonte, Minas Gerais, Brazil</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Experimental Parasitology</title><title level="j" type="abbrev">YEXPR</title><idno type="ISSN">0014-4894</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1978">1978</date><biblScope unit="volume">46</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="145">145</biblScope><biblScope unit="page" to="151">151</biblScope></imprint><idno type="ISSN">0014-4894</idno></series><idno type="istex">ED40CDF5D40B35D6E74AD28118085E682BFE75E6</idno><idno type="DOI">10.1016/0014-4894(78)90126-1</idno><idno type="PII">0014-4894(78)90126-1</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0014-4894</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In this study of the role of the complement system in immunity to schistosomiasis, artificially transformed Schistosoma mansoni, schistosomula were treated with serum from mice with concomitant immunity as a source of antibody (Ab) and with fresh guinea pig serum as a source of complement. Two populations of schistosomula were identifiable. Some were susceptible to the action of complement alone while others were killed only in the presence of antibody and complement. Heated and zymosan treated guinea pig sera were inactive as a source of complement. Guinea pig serum deficient in the fourth component of complement could be used as a source of complement, but it was less effective than normal guinea pig serum. An effect of the complement system in vivo was also observed. Several groups of mice with concomitant immunity were challenged with 270 to 350 cercariae of S. mansoni. Five days later schistosomula were recovered from their lungs and counted. Recovery of worms was significantly increased (P < 0.05) in two out of three experiments in groups of animals which had been pretreated with cobra venom factor to deplete the third component of complement. These results strongly suggest that the complement system is one of the effector mechanisms in concomitant immunity in schistosomiasis.</div></front></TEI><istex><corpusName>elsevier</corpusName><author><json:item><name>C.A.P. Tavares</name><affiliations><json:string>Departamento de Bioquímica-Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, CP 2486, 30.000 Belo Horizonte, Minas Gerais, Brazil</json:string></affiliations></json:item><json:item><name>G. Gazzinelli</name><affiliations><json:string>Departamento de Bioquímica-Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, CP 2486, 30.000 Belo Horizonte, Minas Gerais, Brazil</json:string></affiliations></json:item><json:item><name>T.A. Mota-Santos</name><affiliations><json:string>Departamento de Bioquímica-Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, CP 2486, 30.000 Belo Horizonte, Minas Gerais, Brazil</json:string></affiliations></json:item><json:item><name>W.Dias Da Silva</name><affiliations><json:string>Departamento de Bioquímica-Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, CP 2486, 30.000 Belo Horizonte, Minas Gerais, Brazil</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Schistosoma mansoni</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>trematode</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>blood fluke</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>mouse</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>concomitant immunity</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>complement</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>cytotoxicity</value></json:item></subject><language><json:string>eng</json:string></language><abstract>In this study of the role of the complement system in immunity to schistosomiasis, artificially transformed Schistosoma mansoni, schistosomula were treated with serum from mice with concomitant immunity as a source of antibody (Ab) and with fresh guinea pig serum as a source of complement. Two populations of schistosomula were identifiable. Some were susceptible to the action of complement alone while others were killed only in the presence of antibody and complement. Heated and zymosan treated guinea pig sera were inactive as a source of complement. Guinea pig serum deficient in the fourth component of complement could be used as a source of complement, but it was less effective than normal guinea pig serum. An effect of the complement system in vivo was also observed. Several groups of mice with concomitant immunity were challenged with 270 to 350 cercariae of S. mansoni. Five days later schistosomula were recovered from their lungs and counted. Recovery of worms was significantly increased (P > 0.05) in two out of three experiments in groups of animals which had been pretreated with cobra venom factor to deplete the third component of complement. These results strongly suggest that the complement system is one of the effector mechanisms in concomitant immunity in schistosomiasis.</abstract><qualityIndicators><score>5.006</score><pdfVersion>1.3</pdfVersion><pdfPageSize>504 x 720 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>7</keywordCount><abstractCharCount>1303</abstractCharCount><pdfWordCount>2534</pdfWordCount><pdfCharCount>18429</pdfCharCount><pdfPageCount>7</pdfPageCount><abstractWordCount>206</abstractWordCount></qualityIndicators><title>Schistosoma mansoni: Complement-mediated cytotoxic activity in vitro and effect of decomplementation on acquired immunity in mice</title><pii><json:string>0014-4894(78)90126-1</json:string></pii><genre><json:string>research-article</json:string></genre><serie><volume>36</volume><pages><first>1057</first></pages><genre></genre><language><json:string>unknown</json:string></language><title>Federation 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uri="https://api.istex.fr/document/ED40CDF5D40B35D6E74AD28118085E682BFE75E6/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a">Schistosoma mansoni: Complement-mediated cytotoxic activity in vitro and effect of decomplementation on acquired immunity in mice</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>ELSEVIER</publisher><availability><p>ELSEVIER</p></availability><date>1978</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a">Schistosoma mansoni: Complement-mediated cytotoxic activity in vitro and effect of decomplementation on acquired immunity in mice</title><author><persName><forename type="first">C.A.P.</forename><surname>Tavares</surname></persName><affiliation>Departamento de Bioquímica-Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, CP 2486, 30.000 Belo Horizonte, Minas Gerais, Brazil</affiliation></author><author><persName><forename type="first">G.</forename><surname>Gazzinelli</surname></persName><affiliation>Departamento de Bioquímica-Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, CP 2486, 30.000 Belo Horizonte, Minas Gerais, Brazil</affiliation></author><author><persName><forename type="first">T.A.</forename><surname>Mota-Santos</surname></persName><affiliation>Departamento de Bioquímica-Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, CP 2486, 30.000 Belo Horizonte, Minas Gerais, Brazil</affiliation></author><author><persName><forename type="first">W.Dias</forename><surname>Da Silva</surname></persName><note type="biography">Present address: Departamento de Microbiologia e Imunologia, ICB., USP., São Paulo, Brazil.</note><affiliation>Present address: Departamento de Microbiologia e Imunologia, ICB., USP., São Paulo, Brazil.</affiliation><affiliation>Departamento de Bioquímica-Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, CP 2486, 30.000 Belo Horizonte, Minas Gerais, Brazil</affiliation></author></analytic><monogr><title level="j">Experimental Parasitology</title><title level="j" type="abbrev">YEXPR</title><idno type="pISSN">0014-4894</idno><idno type="PII">S0014-4894(00)X0135-X</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1978"></date><biblScope unit="volume">46</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="145">145</biblScope><biblScope unit="page" to="151">151</biblScope></imprint></monogr><idno type="istex">ED40CDF5D40B35D6E74AD28118085E682BFE75E6</idno><idno type="DOI">10.1016/0014-4894(78)90126-1</idno><idno type="PII">0014-4894(78)90126-1</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1978</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>In this study of the role of the complement system in immunity to schistosomiasis, artificially transformed Schistosoma mansoni, schistosomula were treated with serum from mice with concomitant immunity as a source of antibody (Ab) and with fresh guinea pig serum as a source of complement. Two populations of schistosomula were identifiable. Some were susceptible to the action of complement alone while others were killed only in the presence of antibody and complement. Heated and zymosan treated guinea pig sera were inactive as a source of complement. Guinea pig serum deficient in the fourth component of complement could be used as a source of complement, but it was less effective than normal guinea pig serum. An effect of the complement system in vivo was also observed. Several groups of mice with concomitant immunity were challenged with 270 to 350 cercariae of S. mansoni. Five days later schistosomula were recovered from their lungs and counted. Recovery of worms was significantly increased (P < 0.05) in two out of three experiments in groups of animals which had been pretreated with cobra venom factor to deplete the third component of complement. These results strongly suggest that the complement system is one of the effector mechanisms in concomitant immunity in schistosomiasis.</p></abstract><textClass><keywords scheme="keyword"><list><head>Keywords</head><item><term>Schistosoma mansoni</term></item><item><term>trematode</term></item><item><term>blood fluke</term></item><item><term>mouse</term></item><item><term>concomitant immunity</term></item><item><term>complement</term></item><item><term>cytotoxicity</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1978-07-12">Registration</change><change when="1978">Published</change></revisionDesc></teiHeader></istex:fulltextTEI></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla"><item-info><jid>YEXPR</jid><aid>78901261</aid><ce:pii>0014-4894(78)90126-1</ce:pii><ce:doi>10.1016/0014-4894(78)90126-1</ce:doi><ce:copyright type="unknown" year="1978"></ce:copyright></item-info><head><ce:title><ce:italic>Schistosoma mansoni:</ce:italic> Complement-mediated cytotoxic activity <ce:italic>in vitro</ce:italic> and effect of decomplementation on acquired immunity in mice</ce:title><ce:author-group><ce:author><ce:given-name>C.A.P.</ce:given-name><ce:surname>Tavares</ce:surname></ce:author><ce:author><ce:given-name>G.</ce:given-name><ce:surname>Gazzinelli</ce:surname></ce:author><ce:author><ce:given-name>T.A.</ce:given-name><ce:surname>Mota-Santos</ce:surname></ce:author><ce:author><ce:given-name>W.Dias</ce:given-name><ce:surname>Da Silva</ce:surname><ce:cross-ref refid="FN1"><ce:sup>1</ce:sup></ce:cross-ref></ce:author><ce:affiliation><ce:textfn>Departamento de Bioquímica-Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, CP 2486, 30.000 Belo Horizonte, Minas Gerais, Brazil</ce:textfn></ce:affiliation><ce:footnote id="FN1"><ce:label>1</ce:label><ce:note-para>Present address: Departamento de Microbiologia e Imunologia, ICB., USP., São Paulo, Brazil.</ce:note-para></ce:footnote></ce:author-group><ce:date-accepted day="12" month="7" year="1978"></ce:date-accepted><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>In this study of the role of the complement system in immunity to schistosomiasis, artificially transformed <ce:italic>Schistosoma mansoni</ce:italic>, schistosomula were treated with serum from mice with concomitant immunity as a source of antibody (Ab) and with fresh guinea pig serum as a source of complement. Two populations of schistosomula were identifiable. Some were susceptible to the action of complement alone while others were killed only in the presence of antibody and complement. Heated and zymosan treated guinea pig sera were inactive as a source of complement. Guinea pig serum deficient in the fourth component of complement could be used as a source of complement, but it was less effective than normal guinea pig serum. An effect of the complement system <ce:italic>in vivo</ce:italic> was also observed. Several groups of mice with concomitant immunity were challenged with 270 to 350 cercariae of <ce:italic>S. mansoni</ce:italic>. Five days later schistosomula were recovered from their lungs and counted. Recovery of worms was significantly increased (<ce:italic>P</ce:italic> < 0.05) in two out of three experiments in groups of animals which had been pretreated with cobra venom factor to deplete the third component of complement. These results strongly suggest that the complement system is one of the effector mechanisms in concomitant immunity in schistosomiasis.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords><ce:section-title>Keywords</ce:section-title><ce:keyword><ce:text><ce:italic>Schistosoma mansoni</ce:italic></ce:text></ce:keyword><ce:keyword><ce:text>trematode</ce:text></ce:keyword><ce:keyword><ce:text>blood fluke</ce:text></ce:keyword><ce:keyword><ce:text>mouse</ce:text></ce:keyword><ce:keyword><ce:text>concomitant immunity</ce:text></ce:keyword><ce:keyword><ce:text>complement</ce:text></ce:keyword><ce:keyword><ce:text>cytotoxicity</ce:text></ce:keyword></ce:keywords></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Schistosoma mansoni: Complement-mediated cytotoxic activity in vitro and effect of decomplementation on acquired immunity in mice</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Complement-mediated cytotoxic activity</title></titleInfo><name type="personal"><namePart type="given">C.A.P.</namePart><namePart type="family">Tavares</namePart><affiliation>Departamento de Bioquímica-Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, CP 2486, 30.000 Belo Horizonte, Minas Gerais, Brazil</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G.</namePart><namePart type="family">Gazzinelli</namePart><affiliation>Departamento de Bioquímica-Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, CP 2486, 30.000 Belo Horizonte, Minas Gerais, Brazil</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T.A.</namePart><namePart type="family">Mota-Santos</namePart><affiliation>Departamento de Bioquímica-Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, CP 2486, 30.000 Belo Horizonte, Minas Gerais, Brazil</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W.Dias</namePart><namePart type="family">Da Silva</namePart><affiliation>Departamento de Bioquímica-Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, CP 2486, 30.000 Belo Horizonte, Minas Gerais, Brazil</affiliation><description>Present address: Departamento de Microbiologia e Imunologia, ICB., USP., São Paulo, Brazil.</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article"></genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1978</dateIssued><dateValid encoding="w3cdtf">1978-07-12</dateValid><copyrightDate encoding="w3cdtf">1978</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">In this study of the role of the complement system in immunity to schistosomiasis, artificially transformed Schistosoma mansoni, schistosomula were treated with serum from mice with concomitant immunity as a source of antibody (Ab) and with fresh guinea pig serum as a source of complement. Two populations of schistosomula were identifiable. Some were susceptible to the action of complement alone while others were killed only in the presence of antibody and complement. Heated and zymosan treated guinea pig sera were inactive as a source of complement. Guinea pig serum deficient in the fourth component of complement could be used as a source of complement, but it was less effective than normal guinea pig serum. An effect of the complement system in vivo was also observed. Several groups of mice with concomitant immunity were challenged with 270 to 350 cercariae of S. mansoni. Five days later schistosomula were recovered from their lungs and counted. Recovery of worms was significantly increased (P < 0.05) in two out of three experiments in groups of animals which had been pretreated with cobra venom factor to deplete the third component of complement. These results strongly suggest that the complement system is one of the effector mechanisms in concomitant immunity in schistosomiasis.</abstract><subject><genre>Keywords</genre><topic>Schistosoma mansoni</topic><topic>trematode</topic><topic>blood fluke</topic><topic>mouse</topic><topic>concomitant immunity</topic><topic>complement</topic><topic>cytotoxicity</topic></subject><relatedItem type="host"><titleInfo><title>Experimental Parasitology</title></titleInfo><titleInfo type="abbreviated"><title>YEXPR</title></titleInfo><genre type="Journal">journal</genre><originInfo><dateIssued encoding="w3cdtf">197812</dateIssued></originInfo><identifier type="ISSN">0014-4894</identifier><identifier type="PII">S0014-4894(00)X0135-X</identifier><part><date>197812</date><detail type="volume"><number>46</number><caption>vol.</caption></detail><detail type="issue"><number>2</number><caption>no.</caption></detail><extent unit="issue pages"><start>133</start><end>354</end></extent><extent unit="pages"><start>145</start><end>151</end></extent></part></relatedItem><identifier type="istex">ED40CDF5D40B35D6E74AD28118085E682BFE75E6</identifier><identifier type="DOI">10.1016/0014-4894(78)90126-1</identifier><identifier type="PII">0014-4894(78)90126-1</identifier><recordInfo><recordContentSource>ELSEVIER</recordContentSource></recordInfo></mods></metadata><enrichments><istex:catWosTEI uri="https://api.istex.fr/document/ED40CDF5D40B35D6E74AD28118085E682BFE75E6/enrichments/catWos"><teiHeader><profileDesc><textClass><classCode scheme="WOS">PARASITOLOGY</classCode></textClass></profileDesc></teiHeader></istex:catWosTEI></enrichments></istex></record>Pour manipuler ce document sous Unix (Dilib)
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|texte= Schistosoma mansoni: Complement-mediated cytotoxic activity in vitro and effect of decomplementation on acquired immunity in mice
}}
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