The effects of periodontal therapy on serum antibody (IgG) levels to plaque microorganisms
Identifieur interne : 000D77 ( Istex/Corpus ); précédent : 000D76; suivant : 000D78The effects of periodontal therapy on serum antibody (IgG) levels to plaque microorganisms
Auteurs : Ikramuddin Aukhil ; Dennis E. Lopatinct ; Salam A. Syed ; Edith C. Morrison ; Charles J. KowatskSource :
- Journal of Clinical Periodontology [ 0303-6979 ] ; 1988-10.
English descriptors
Abstract
Abstract. The influence of periodontal therapy on serum antibody titers to selected periodontal disease‐associated microorganisms was assessed in 23 patients having chronic inflammatory periodontal disease (CIPD), The immunoglobulin G (IgG) titers were détérmined by the micro ELISA technique in serum samples obtained prior to treatment; following a hygienic phase which included scaling, root planing, and oral hygiene instruction; following surgical treatment; and one year and two years following hygienic phase (maintenance phase). Considerable individual variability existed in the magnitude of immune response to specific bacterial preparations. Significant reductions in the mean antibody titers were seen to A. viscosus. S. sanguis. F. nucleatum, S, spuligena, B. gingivalis. B. interme‐dius. B. melaninogeniem, T. vincentii, and T denticola by the end of the second year of maintenance. There was no consistent response to Capnucytophaga. When individual patient responses were examined. 6 of the 23 were found to have elevated titers to at least one of the microorganisms in the interval between pretreatment and the end of the hygienic phase; however, in all but one case, the titers at the end of the second year of maintenance were below pretreatment levels. Antibody levels to bacteria such as S. sanguis were modified during therapy. This would indicate that immune responses to microbes not generally considered to be “periodontal pathogens” may be modified by adjuvant activity associated with subgingival plaque or changes in the environment of the sulcus and that subsequent changes in titer do not necessarily reflect a role of that microorganism in the disease process.
Url:
DOI: 10.1111/j.1600-051X.1988.tb02127.x
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ISTEX:23BC6B05AC50DC47739E1696C6D903FCF4A7DF36Le document en format XML
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Lopatinct</name><affiliation><mods:affiliation>Oral Biology, The University of Michigan, Ann Arbor, Michigan 48109–0402, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>The Dental Research Instituted, The University of Michigan, Ann Arbor, Michigan 48109–0402, USA</mods:affiliation></affiliation></author><author><name sortKey="Syed, Salam A" sort="Syed, Salam A" uniqKey="Syed S" first="Salam A." last="Syed">Salam A. Syed</name><affiliation><mods:affiliation>Oral Biology, The University of Michigan, Ann Arbor, Michigan 48109–0402, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>The Dental Research Instituted, The University of Michigan, Ann Arbor, Michigan 48109–0402, USA</mods:affiliation></affiliation></author><author><name sortKey="Morrison, Edith C" sort="Morrison, Edith C" uniqKey="Morrison E" first="Edith C." last="Morrison">Edith C. Morrison</name><affiliation><mods:affiliation>Departments of Periodontics, The University of Michigan, Ann Arbor, Michigan 48109–0402, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>The Dental Research Instituted, The University of Michigan, Ann Arbor, Michigan 48109–0402, USA</mods:affiliation></affiliation></author><author><name sortKey="Kowatsk, Charles J" sort="Kowatsk, Charles J" uniqKey="Kowatsk C" first="Charles J." last="Kowatsk">Charles J. 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Lopatinct</name><affiliation><mods:affiliation>Oral Biology, The University of Michigan, Ann Arbor, Michigan 48109–0402, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>The Dental Research Instituted, The University of Michigan, Ann Arbor, Michigan 48109–0402, USA</mods:affiliation></affiliation></author><author><name sortKey="Syed, Salam A" sort="Syed, Salam A" uniqKey="Syed S" first="Salam A." last="Syed">Salam A. Syed</name><affiliation><mods:affiliation>Oral Biology, The University of Michigan, Ann Arbor, Michigan 48109–0402, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>The Dental Research Instituted, The University of Michigan, Ann Arbor, Michigan 48109–0402, USA</mods:affiliation></affiliation></author><author><name sortKey="Morrison, Edith C" sort="Morrison, Edith C" uniqKey="Morrison E" first="Edith C." last="Morrison">Edith C. Morrison</name><affiliation><mods:affiliation>Departments of Periodontics, The University of Michigan, Ann Arbor, Michigan 48109–0402, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>The Dental Research Instituted, The University of Michigan, Ann Arbor, Michigan 48109–0402, USA</mods:affiliation></affiliation></author><author><name sortKey="Kowatsk, Charles J" sort="Kowatsk, Charles J" uniqKey="Kowatsk C" first="Charles J." last="Kowatsk">Charles J. Kowatsk</name><affiliation><mods:affiliation>Oral Biology, The University of Michigan, Ann Arbor, Michigan 48109–0402, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>The Dental Research Instituted, The University of Michigan, Ann Arbor, Michigan 48109–0402, USA</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Clinical Periodontology</title><idno type="ISSN">0303-6979</idno><idno type="eISSN">1600-051X</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="1988-10">1988-10</date><biblScope unit="volume">15</biblScope><biblScope unit="issue">9</biblScope><biblScope unit="page" from="544">544</biblScope><biblScope unit="page" to="550">550</biblScope></imprint><idno type="ISSN">0303-6979</idno></series><idno type="istex">23BC6B05AC50DC47739E1696C6D903FCF4A7DF36</idno><idno type="DOI">10.1111/j.1600-051X.1988.tb02127.x</idno><idno type="ArticleID">JCPE544</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0303-6979</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>antibodies</term><term>immunoglobulins</term><term>longitudinal study</term><term>periodontal therapy</term><term>plaque microorganisms</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract. The influence of periodontal therapy on serum antibody titers to selected periodontal disease‐associated microorganisms was assessed in 23 patients having chronic inflammatory periodontal disease (CIPD), The immunoglobulin G (IgG) titers were détérmined by the micro ELISA technique in serum samples obtained prior to treatment; following a hygienic phase which included scaling, root planing, and oral hygiene instruction; following surgical treatment; and one year and two years following hygienic phase (maintenance phase). Considerable individual variability existed in the magnitude of immune response to specific bacterial preparations. Significant reductions in the mean antibody titers were seen to A. viscosus. S. sanguis. F. nucleatum, S, spuligena, B. gingivalis. B. interme‐dius. B. melaninogeniem, T. vincentii, and T denticola by the end of the second year of maintenance. There was no consistent response to Capnucytophaga. When individual patient responses were examined. 6 of the 23 were found to have elevated titers to at least one of the microorganisms in the interval between pretreatment and the end of the hygienic phase; however, in all but one case, the titers at the end of the second year of maintenance were below pretreatment levels. Antibody levels to bacteria such as S. sanguis were modified during therapy. This would indicate that immune responses to microbes not generally considered to be “periodontal pathogens” may be modified by adjuvant activity associated with subgingival plaque or changes in the environment of the sulcus and that subsequent changes in titer do not necessarily reflect a role of that microorganism in the disease process.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Ikramuddin Aukhil</name><affiliations><json:string>Departments of Periodontics, The University of Michigan, Ann Arbor, Michigan 48109–0402, USA</json:string></affiliations></json:item><json:item><name>Dennis E. Lopatinct</name><affiliations><json:string>Oral Biology, The University of Michigan, Ann Arbor, Michigan 48109–0402, USA</json:string><json:string>The Dental Research Instituted, The University of Michigan, Ann Arbor, Michigan 48109–0402, USA</json:string></affiliations></json:item><json:item><name>Salam A. Syed</name><affiliations><json:string>Oral Biology, The University of Michigan, Ann Arbor, Michigan 48109–0402, USA</json:string><json:string>The Dental Research Instituted, The University of Michigan, Ann Arbor, Michigan 48109–0402, USA</json:string></affiliations></json:item><json:item><name>Edith C. Morrison</name><affiliations><json:string>Departments of Periodontics, The University of Michigan, Ann Arbor, Michigan 48109–0402, USA</json:string><json:string>The Dental Research Instituted, The University of Michigan, Ann Arbor, Michigan 48109–0402, USA</json:string></affiliations></json:item><json:item><name>Charles J. Kowatsk</name><affiliations><json:string>Oral Biology, The University of Michigan, Ann Arbor, Michigan 48109–0402, USA</json:string><json:string>The Dental Research Instituted, The University of Michigan, Ann Arbor, Michigan 48109–0402, USA</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>periodontal therapy</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>antibodies</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>plaque microorganisms</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>immunoglobulins</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>longitudinal study</value></json:item></subject><articleId><json:string>JCPE544</json:string></articleId><language><json:string>eng</json:string></language><abstract>Abstract. The influence of periodontal therapy on serum antibody titers to selected periodontal disease‐associated microorganisms was assessed in 23 patients having chronic inflammatory periodontal disease (CIPD), The immunoglobulin G (IgG) titers were détérmined by the micro ELISA technique in serum samples obtained prior to treatment; following a hygienic phase which included scaling, root planing, and oral hygiene instruction; following surgical treatment; and one year and two years following hygienic phase (maintenance phase). Considerable individual variability existed in the magnitude of immune response to specific bacterial preparations. Significant reductions in the mean antibody titers were seen to A. viscosus. S. sanguis. F. nucleatum, S, spuligena, B. gingivalis. B. interme‐dius. B. melaninogeniem, T. vincentii, and T denticola by the end of the second year of maintenance. There was no consistent response to Capnucytophaga. When individual patient responses were examined. 6 of the 23 were found to have elevated titers to at least one of the microorganisms in the interval between pretreatment and the end of the hygienic phase; however, in all but one case, the titers at the end of the second year of maintenance were below pretreatment levels. Antibody levels to bacteria such as S. sanguis were modified during therapy. This would indicate that immune responses to microbes not generally considered to be “periodontal pathogens” may be modified by adjuvant activity associated with subgingival plaque or changes in the environment of the sulcus and that subsequent changes in titer do not necessarily reflect a role of that microorganism in the disease process.</abstract><qualityIndicators><score>8.325</score><pdfVersion>1.4</pdfVersion><pdfPageSize>342 x 492 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>5</keywordCount><abstractCharCount>1691</abstractCharCount><pdfWordCount>4825</pdfWordCount><pdfCharCount>30944</pdfCharCount><pdfPageCount>8</pdfPageCount><abstractWordCount>251</abstractWordCount></qualityIndicators><title>The effects of periodontal therapy on serum antibody (IgG) levels to plaque microorganisms</title><genre><json:string>article</json:string></genre><host><volume>15</volume><publisherId><json:string>JCPE</json:string></publisherId><pages><total>7</total><last>550</last><first>544</first></pages><issn><json:string>0303-6979</json:string></issn><issue>9</issue><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1600-051X</json:string></eissn><title>Journal of Clinical Periodontology</title><doi><json:string>10.1111/(ISSN)1600-051X</json:string></doi></host><publicationDate>1988</publicationDate><copyrightDate>1988</copyrightDate><doi><json:string>10.1111/j.1600-051X.1988.tb02127.x</json:string></doi><id>23BC6B05AC50DC47739E1696C6D903FCF4A7DF36</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/23BC6B05AC50DC47739E1696C6D903FCF4A7DF36/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/23BC6B05AC50DC47739E1696C6D903FCF4A7DF36/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/23BC6B05AC50DC47739E1696C6D903FCF4A7DF36/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">The effects of periodontal therapy on serum antibody (IgG) levels to plaque microorganisms</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><availability><p>WILEY</p></availability><date>1988</date></publicationStmt><notesStmt><note type="content">*This work was supported by United States Public Health Service Grant DE 02731 from the National Institute for Dental Research.</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">The effects of periodontal therapy on serum antibody (IgG) levels to plaque microorganisms</title><author><persName><forename type="first">Ikramuddin</forename><surname>Aukhil</surname></persName><note type="biography">Current address: Department of Periodontics, University of North Carolina at Chapel Hill, School of Dentistry 209H, Chapel Hill, North Carolina 27514, USA.</note><affiliation>Current address: Department of Periodontics, University of North Carolina at Chapel Hill, School of Dentistry 209H, Chapel Hill, North Carolina 27514, USA.</affiliation><affiliation>Departments of Periodontics, The University of Michigan, Ann Arbor, Michigan 48109–0402, USA</affiliation></author><author><persName><forename type="first">Dennis E.</forename><surname>Lopatinct</surname></persName><note type="correspondence"><p>Correspondence: Dennis E. Lopatin, 300 North Ingalls Building. Roam 1192, School of Dentistry, The University of Michigan, Ann Arbor. Michigan 48109‐0402, USA</p></note><affiliation>Oral Biology, The University of Michigan, Ann Arbor, Michigan 48109–0402, USA</affiliation><affiliation>The Dental Research Instituted, The University of Michigan, Ann Arbor, Michigan 48109–0402, USA</affiliation></author><author><persName><forename type="first">Salam A.</forename><surname>Syed</surname></persName><affiliation>Oral Biology, The University of Michigan, Ann Arbor, Michigan 48109–0402, USA</affiliation><affiliation>The Dental Research Instituted, The University of Michigan, Ann Arbor, Michigan 48109–0402, USA</affiliation></author><author><persName><forename type="first">Edith C.</forename><surname>Morrison</surname></persName><affiliation>Departments of Periodontics, The University of Michigan, Ann Arbor, Michigan 48109–0402, USA</affiliation><affiliation>The Dental Research Instituted, The University of Michigan, Ann Arbor, Michigan 48109–0402, USA</affiliation></author><author><persName><forename type="first">Charles J.</forename><surname>Kowatsk</surname></persName><affiliation>Oral Biology, The University of Michigan, Ann Arbor, Michigan 48109–0402, USA</affiliation><affiliation>The Dental Research Instituted, The University of Michigan, Ann Arbor, Michigan 48109–0402, USA</affiliation></author></analytic><monogr><title level="j">Journal of Clinical Periodontology</title><idno type="pISSN">0303-6979</idno><idno type="eISSN">1600-051X</idno><idno type="DOI">10.1111/(ISSN)1600-051X</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="1988-10"></date><biblScope unit="volume">15</biblScope><biblScope unit="issue">9</biblScope><biblScope unit="page" from="544">544</biblScope><biblScope unit="page" to="550">550</biblScope></imprint></monogr><idno type="istex">23BC6B05AC50DC47739E1696C6D903FCF4A7DF36</idno><idno type="DOI">10.1111/j.1600-051X.1988.tb02127.x</idno><idno type="ArticleID">JCPE544</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1988</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Abstract. The influence of periodontal therapy on serum antibody titers to selected periodontal disease‐associated microorganisms was assessed in 23 patients having chronic inflammatory periodontal disease (CIPD), The immunoglobulin G (IgG) titers were détérmined by the micro ELISA technique in serum samples obtained prior to treatment; following a hygienic phase which included scaling, root planing, and oral hygiene instruction; following surgical treatment; and one year and two years following hygienic phase (maintenance phase). Considerable individual variability existed in the magnitude of immune response to specific bacterial preparations. Significant reductions in the mean antibody titers were seen to A. viscosus. S. sanguis. F. nucleatum, S, spuligena, B. gingivalis. B. interme‐dius. B. melaninogeniem, T. vincentii, and T denticola by the end of the second year of maintenance. There was no consistent response to Capnucytophaga. When individual patient responses were examined. 6 of the 23 were found to have elevated titers to at least one of the microorganisms in the interval between pretreatment and the end of the hygienic phase; however, in all but one case, the titers at the end of the second year of maintenance were below pretreatment levels. Antibody levels to bacteria such as S. sanguis were modified during therapy. This would indicate that immune responses to microbes not generally considered to be “periodontal pathogens” may be modified by adjuvant activity associated with subgingival plaque or changes in the environment of the sulcus and that subsequent changes in titer do not necessarily reflect a role of that microorganism in the disease process.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>periodontal therapy</term></item><item><term>antibodies</term></item><item><term>plaque microorganisms</term></item><item><term>immunoglobulins</term></item><item><term>longitudinal study</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1988-10">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/23BC6B05AC50DC47739E1696C6D903FCF4A7DF36/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Ltd</publisherName><publisherLoc>Oxford, UK</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1600-051X</doi><issn type="print">0303-6979</issn><issn type="electronic">1600-051X</issn><idGroup><id type="product" value="JCPE"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="JOURNAL OF CLINICAL PERIODONTOLOGY">Journal of Clinical Periodontology</title></titleGroup></publicationMeta><publicationMeta level="part" position="10009"><doi origin="wiley">10.1111/cpe.1988.15.issue-9</doi><numberingGroup><numbering type="journalVolume" number="15">15</numbering><numbering type="journalIssue" number="9">9</numbering></numberingGroup><coverDate startDate="1988-10">October 1988</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="0054400" status="forIssue"><doi origin="wiley">10.1111/j.1600-051X.1988.tb02127.x</doi><idGroup><id type="unit" value="JCPE544"></id></idGroup><countGroup><count type="pageTotal" number="7"></count></countGroup><titleGroup><title type="tocHeading1">Original Articles</title></titleGroup><eventGroup><event type="firstOnline" date="2005-12-14"></event><event type="publishedOnlineFinalForm" date="2005-12-14"></event><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.3.2 mode:FullText source:HeaderRef result:HeaderRef" date="2010-03-09"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:4.0.1" date="2014-03-19"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-23"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="544">544</numbering><numbering type="pageLast" number="550">550</numbering></numberingGroup><correspondenceTo>Dennis E. Lopatin, 300 North Ingalls Building. Roam 1192, School of Dentistry, The University of Michigan, Ann Arbor. Michigan 48109‐0402, USA</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:JCPE.JCPE544.pdf"></link></linkGroup></publicationMeta><contentMeta><unparsedEditorialHistory>Accepted for publication 28 November 1987</unparsedEditorialHistory><countGroup><count type="referenceTotal" number="31"></count><count type="linksCrossRef" number="12"></count></countGroup><titleGroup><title type="main">The effects of periodontal therapy on serum antibody (IgG) levels to plaque microorganisms<link href="#fn2">*</link></title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1" noteRef="#fn1"><personName><givenNames>Ikramuddin</givenNames><familyName>Aukhil</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a2 #a3" corresponding="yes"><personName><givenNames>Dennis E.</givenNames><familyName>Lopatinct</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a2 #a3"><personName><givenNames>Salam A.</givenNames><familyName>Syed</familyName></personName></creator><creator creatorRole="author" xml:id="cr4" affiliationRef="#a1 #a3"><personName><givenNames>Edith C.</givenNames><familyName>Morrison</familyName></personName></creator><creator creatorRole="author" xml:id="cr5" affiliationRef="#a2 #a3"><personName><givenNames>Charles J.</givenNames><familyName>Kowatsk</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1" countryCode="US"><unparsedAffiliation>Departments of Periodontics, The University of Michigan, Ann Arbor, Michigan 48109–0402, USA</unparsedAffiliation></affiliation><affiliation xml:id="a2" countryCode="US"><unparsedAffiliation>Oral Biology, The University of Michigan, Ann Arbor, Michigan 48109–0402, USA</unparsedAffiliation></affiliation><affiliation xml:id="a3" countryCode="US"><unparsedAffiliation> The Dental Research Institute<sup>d</sup>, The University of Michigan, Ann Arbor, Michigan 48109–0402, USA</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1">periodontal therapy</keyword><keyword xml:id="k2">antibodies</keyword><keyword xml:id="k3">plaque microorganisms</keyword><keyword xml:id="k4">immunoglobulins</keyword><keyword xml:id="k5">longitudinal study</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><p><b>Abstract. </b> The influence of periodontal therapy on serum antibody titers to selected periodontal disease‐associated microorganisms was assessed in 23 patients having chronic inflammatory periodontal disease (CIPD), The immunoglobulin G (IgG) titers were détérmined by the micro ELISA technique in serum samples obtained prior to treatment; following a hygienic phase which included scaling, root planing, and oral hygiene instruction; following surgical treatment; and one year and two years following hygienic phase (maintenance phase). Considerable individual variability existed in the magnitude of immune response to specific bacterial preparations. Significant reductions in the mean antibody titers were seen to <i>A. viscosus. S. sanguis. F. nucleatum, S, spuligena, B. gingivalis. B. interme‐dius. B. melaninogeniem, T. vincentii</i>, and <i>T denticola</i> by the end of the second year of maintenance. There was no consistent response to <i>Capnucytophaga.</i> When individual patient responses were examined. 6 of the 23 were found to have elevated titers to at least one of the microorganisms in the interval between pretreatment and the end of the hygienic phase; however, in all but one case, the titers at the end of the second year of maintenance were below pretreatment levels. Antibody levels to bacteria such as <i>S. sanguis</i> were modified during therapy. This would indicate that immune responses to microbes not generally considered to be “periodontal pathogens” may be modified by adjuvant activity associated with subgingival plaque or changes in the environment of the sulcus and that subsequent changes in titer do not necessarily reflect a role of that microorganism in the disease process.</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn1"><label>a</label><p>Current address: Department of Periodontics, University of North Carolina at Chapel Hill, School of Dentistry 209H, Chapel Hill, North Carolina 27514, USA.</p></note><note xml:id="fn2"><label>*</label><p>This work was supported by United States Public Health Service Grant DE 02731 from the National Institute for Dental Research.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>The effects of periodontal therapy on serum antibody (IgG) levels to plaque microorganisms</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>The effects of periodontal therapy on serum antibody (IgG) levels to plaque microorganisms</title></titleInfo><name type="personal"><namePart type="given">Ikramuddin</namePart><namePart type="family">Aukhil</namePart><affiliation>Departments of Periodontics, The University of Michigan, Ann Arbor, Michigan 48109–0402, USA</affiliation><description>Current address: Department of Periodontics, University of North Carolina at Chapel Hill, School of Dentistry 209H, Chapel Hill, North Carolina 27514, USA.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Dennis E.</namePart><namePart type="family">Lopatinct</namePart><affiliation>Oral Biology, The University of Michigan, Ann Arbor, Michigan 48109–0402, USA</affiliation><affiliation>The Dental Research Instituted, The University of Michigan, Ann Arbor, Michigan 48109–0402, USA</affiliation><description>Correspondence: Dennis E. Lopatin, 300 North Ingalls Building. Roam 1192, School of Dentistry, The University of Michigan, Ann Arbor. Michigan 48109‐0402, USA</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Salam A.</namePart><namePart type="family">Syed</namePart><affiliation>Oral Biology, The University of Michigan, Ann Arbor, Michigan 48109–0402, USA</affiliation><affiliation>The Dental Research Instituted, The University of Michigan, Ann Arbor, Michigan 48109–0402, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Edith C.</namePart><namePart type="family">Morrison</namePart><affiliation>Departments of Periodontics, The University of Michigan, Ann Arbor, Michigan 48109–0402, USA</affiliation><affiliation>The Dental Research Instituted, The University of Michigan, Ann Arbor, Michigan 48109–0402, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Charles J.</namePart><namePart type="family">Kowatsk</namePart><affiliation>Oral Biology, The University of Michigan, Ann Arbor, Michigan 48109–0402, USA</affiliation><affiliation>The Dental Research Instituted, The University of Michigan, Ann Arbor, Michigan 48109–0402, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">1988-10</dateIssued><edition>Accepted for publication 28 November 1987</edition><copyrightDate encoding="w3cdtf">1988</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="references">31</extent></physicalDescription><abstract lang="en">Abstract. The influence of periodontal therapy on serum antibody titers to selected periodontal disease‐associated microorganisms was assessed in 23 patients having chronic inflammatory periodontal disease (CIPD), The immunoglobulin G (IgG) titers were détérmined by the micro ELISA technique in serum samples obtained prior to treatment; following a hygienic phase which included scaling, root planing, and oral hygiene instruction; following surgical treatment; and one year and two years following hygienic phase (maintenance phase). Considerable individual variability existed in the magnitude of immune response to specific bacterial preparations. Significant reductions in the mean antibody titers were seen to A. viscosus. S. sanguis. F. nucleatum, S, spuligena, B. gingivalis. B. interme‐dius. B. melaninogeniem, T. vincentii, and T denticola by the end of the second year of maintenance. There was no consistent response to Capnucytophaga. When individual patient responses were examined. 6 of the 23 were found to have elevated titers to at least one of the microorganisms in the interval between pretreatment and the end of the hygienic phase; however, in all but one case, the titers at the end of the second year of maintenance were below pretreatment levels. Antibody levels to bacteria such as S. sanguis were modified during therapy. This would indicate that immune responses to microbes not generally considered to be “periodontal pathogens” may be modified by adjuvant activity associated with subgingival plaque or changes in the environment of the sulcus and that subsequent changes in titer do not necessarily reflect a role of that microorganism in the disease process.</abstract><note type="content">*This work was supported by United States Public Health Service Grant DE 02731 from the National Institute for Dental Research.</note><subject lang="en"><genre>Keywords</genre><topic>periodontal therapy</topic><topic>antibodies</topic><topic>plaque microorganisms</topic><topic>immunoglobulins</topic><topic>longitudinal study</topic></subject><relatedItem type="host"><titleInfo><title>Journal of Clinical Periodontology</title></titleInfo><genre type="Journal">journal</genre><identifier type="ISSN">0303-6979</identifier><identifier type="eISSN">1600-051X</identifier><identifier type="DOI">10.1111/(ISSN)1600-051X</identifier><identifier type="PublisherID">JCPE</identifier><part><date>1988</date><detail type="volume"><caption>vol.</caption><number>15</number></detail><detail type="issue"><caption>no.</caption><number>9</number></detail><extent unit="pages"><start>544</start><end>550</end><total>7</total></extent></part></relatedItem><identifier type="istex">23BC6B05AC50DC47739E1696C6D903FCF4A7DF36</identifier><identifier type="DOI">10.1111/j.1600-051X.1988.tb02127.x</identifier><identifier type="ArticleID">JCPE544</identifier><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Blackwell Publishing Ltd</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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