Immunologic events in pigeon breeders' disease
Identifieur interne : 000958 ( Istex/Corpus ); précédent : 000957; suivant : 000959Immunologic events in pigeon breeders' disease
Auteurs : Vernon L. Moore ; Jordan N. Fink ; Joseph J. Barboriak ; Louis L. Ruff ; Donald P. SchlueterSource :
- The Journal of Allergy and Clinical Immunology [ 0091-6749 ] ; 1973.
Abstract
The immunologic and physiologic status of a group of symptomatic and asymptomatic pigeon breeders was studied in an attempt to define the immunologic events occurring in pigeon breeders' disease. Antibody activity to antigen(s) present in pigeon dropping extract (PDE) and pigeon serum (PS) was detected in the serum of both symptomatic and asymptomatic breeders. Antibody activity, however, tended to be greater in the symptomatic pigeon breeders. When subjects were challenged with PS via aerosol, serum complement activity became depressed only in asymptomatic patients. Cellular hypersensitivity to antigens present in PDE was detected in vitro in peripheral lymphocyte populations of 4 of 5 symptomatic breeders and in none of the asymptomatic breeders; cellular hypersensitivity to antigens in PS was not demonstrated in any of the individuals tested. These findings indicate that cell-mediated hypersensitivity, as well as humoral immunologic processes, may be involved in the pathogenesis of the hypersensitivity pneumonitis found in pigeon breeders.
Url:
DOI: 10.1016/0091-6749(74)90115-8
Links to Exploration step
ISTEX:87BA6495D7936A90F8292D197CCEF2A8798C2F08Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Immunologic events in pigeon breeders' disease</title><author><name sortKey="Moore, Vernon L" sort="Moore, Vernon L" uniqKey="Moore V" first="Vernon L." last="Moore">Vernon L. Moore</name><affiliation><mods:affiliation>From the Allergy and Medical Chest Sections, Department of Medicine and the Department of Pharmacology, The Medical College of Wisconsin Milwaukee, Wis., USA</mods:affiliation></affiliation><affiliation><mods:affiliation>From the Research Service, Wood Veterans Administration Hospital Milwaukee, Wis., USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Reprint requests to: Vernon L. Moore, Ph.D., Research Service/151, VA Center, Wood, Wis. 53193.</mods:affiliation></affiliation></author><author><name sortKey="Fink, Jordan N" sort="Fink, Jordan N" uniqKey="Fink J" first="Jordan N." last="Fink">Jordan N. Fink</name><affiliation><mods:affiliation>From the Allergy and Medical Chest Sections, Department of Medicine and the Department of Pharmacology, The Medical College of Wisconsin Milwaukee, Wis., USA</mods:affiliation></affiliation><affiliation><mods:affiliation>From the Research Service, Wood Veterans Administration Hospital Milwaukee, Wis., USA</mods:affiliation></affiliation></author><author><name sortKey="Barboriak, Joseph J" sort="Barboriak, Joseph J" uniqKey="Barboriak J" first="Joseph J." last="Barboriak">Joseph J. Barboriak</name><affiliation><mods:affiliation>From the Allergy and Medical Chest Sections, Department of Medicine and the Department of Pharmacology, The Medical College of Wisconsin Milwaukee, Wis., USA</mods:affiliation></affiliation><affiliation><mods:affiliation>From the Research Service, Wood Veterans Administration Hospital Milwaukee, Wis., USA</mods:affiliation></affiliation></author><author><name sortKey="Ruff, Louis L" sort="Ruff, Louis L" uniqKey="Ruff L" first="Louis L." last="Ruff">Louis L. Ruff</name><affiliation><mods:affiliation>From the Allergy and Medical Chest Sections, Department of Medicine and the Department of Pharmacology, The Medical College of Wisconsin Milwaukee, Wis., USA</mods:affiliation></affiliation><affiliation><mods:affiliation>From the Research Service, Wood Veterans Administration Hospital Milwaukee, Wis., USA</mods:affiliation></affiliation></author><author><name sortKey="Schlueter, Donald P" sort="Schlueter, Donald P" uniqKey="Schlueter D" first="Donald P." last="Schlueter">Donald P. Schlueter</name><affiliation><mods:affiliation>From the Allergy and Medical Chest Sections, Department of Medicine and the Department of Pharmacology, The Medical College of Wisconsin Milwaukee, Wis., USA</mods:affiliation></affiliation><affiliation><mods:affiliation>From the Research Service, Wood Veterans Administration Hospital Milwaukee, Wis., USA</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:87BA6495D7936A90F8292D197CCEF2A8798C2F08</idno><date when="1974" year="1974">1974</date><idno type="doi">10.1016/0091-6749(74)90115-8</idno><idno type="url">https://api.istex.fr/document/87BA6495D7936A90F8292D197CCEF2A8798C2F08/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000958</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Immunologic events in pigeon breeders' disease</title><author><name sortKey="Moore, Vernon L" sort="Moore, Vernon L" uniqKey="Moore V" first="Vernon L." last="Moore">Vernon L. Moore</name><affiliation><mods:affiliation>From the Allergy and Medical Chest Sections, Department of Medicine and the Department of Pharmacology, The Medical College of Wisconsin Milwaukee, Wis., USA</mods:affiliation></affiliation><affiliation><mods:affiliation>From the Research Service, Wood Veterans Administration Hospital Milwaukee, Wis., USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Reprint requests to: Vernon L. Moore, Ph.D., Research Service/151, VA Center, Wood, Wis. 53193.</mods:affiliation></affiliation></author><author><name sortKey="Fink, Jordan N" sort="Fink, Jordan N" uniqKey="Fink J" first="Jordan N." last="Fink">Jordan N. Fink</name><affiliation><mods:affiliation>From the Allergy and Medical Chest Sections, Department of Medicine and the Department of Pharmacology, The Medical College of Wisconsin Milwaukee, Wis., USA</mods:affiliation></affiliation><affiliation><mods:affiliation>From the Research Service, Wood Veterans Administration Hospital Milwaukee, Wis., USA</mods:affiliation></affiliation></author><author><name sortKey="Barboriak, Joseph J" sort="Barboriak, Joseph J" uniqKey="Barboriak J" first="Joseph J." last="Barboriak">Joseph J. Barboriak</name><affiliation><mods:affiliation>From the Allergy and Medical Chest Sections, Department of Medicine and the Department of Pharmacology, The Medical College of Wisconsin Milwaukee, Wis., USA</mods:affiliation></affiliation><affiliation><mods:affiliation>From the Research Service, Wood Veterans Administration Hospital Milwaukee, Wis., USA</mods:affiliation></affiliation></author><author><name sortKey="Ruff, Louis L" sort="Ruff, Louis L" uniqKey="Ruff L" first="Louis L." last="Ruff">Louis L. Ruff</name><affiliation><mods:affiliation>From the Allergy and Medical Chest Sections, Department of Medicine and the Department of Pharmacology, The Medical College of Wisconsin Milwaukee, Wis., USA</mods:affiliation></affiliation><affiliation><mods:affiliation>From the Research Service, Wood Veterans Administration Hospital Milwaukee, Wis., USA</mods:affiliation></affiliation></author><author><name sortKey="Schlueter, Donald P" sort="Schlueter, Donald P" uniqKey="Schlueter D" first="Donald P." last="Schlueter">Donald P. Schlueter</name><affiliation><mods:affiliation>From the Allergy and Medical Chest Sections, Department of Medicine and the Department of Pharmacology, The Medical College of Wisconsin Milwaukee, Wis., USA</mods:affiliation></affiliation><affiliation><mods:affiliation>From the Research Service, Wood Veterans Administration Hospital Milwaukee, Wis., USA</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">The Journal of Allergy and Clinical Immunology</title><title level="j" type="abbrev">YMAI</title><idno type="ISSN">0091-6749</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1973">1973</date><biblScope unit="volume">53</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="319">319</biblScope><biblScope unit="page" to="328">328</biblScope></imprint><idno type="ISSN">0091-6749</idno></series><idno type="istex">87BA6495D7936A90F8292D197CCEF2A8798C2F08</idno><idno type="DOI">10.1016/0091-6749(74)90115-8</idno><idno type="PII">0091-6749(74)90115-8</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0091-6749</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The immunologic and physiologic status of a group of symptomatic and asymptomatic pigeon breeders was studied in an attempt to define the immunologic events occurring in pigeon breeders' disease. Antibody activity to antigen(s) present in pigeon dropping extract (PDE) and pigeon serum (PS) was detected in the serum of both symptomatic and asymptomatic breeders. Antibody activity, however, tended to be greater in the symptomatic pigeon breeders. When subjects were challenged with PS via aerosol, serum complement activity became depressed only in asymptomatic patients. Cellular hypersensitivity to antigens present in PDE was detected in vitro in peripheral lymphocyte populations of 4 of 5 symptomatic breeders and in none of the asymptomatic breeders; cellular hypersensitivity to antigens in PS was not demonstrated in any of the individuals tested. These findings indicate that cell-mediated hypersensitivity, as well as humoral immunologic processes, may be involved in the pathogenesis of the hypersensitivity pneumonitis found in pigeon breeders.</div></front></TEI><istex><corpusName>elsevier</corpusName><author><json:item><name>Vernon L. Moore Ph.D.</name><affiliations><json:string>From the Allergy and Medical Chest Sections, Department of Medicine and the Department of Pharmacology, The Medical College of Wisconsin Milwaukee, Wis., USA</json:string><json:string>From the Research Service, Wood Veterans Administration Hospital Milwaukee, Wis., USA</json:string><json:string>Reprint requests to: Vernon L. Moore, Ph.D., Research Service/151, VA Center, Wood, Wis. 53193.</json:string></affiliations></json:item><json:item><name>Jordan N. Fink M.D.</name><affiliations><json:string>From the Allergy and Medical Chest Sections, Department of Medicine and the Department of Pharmacology, The Medical College of Wisconsin Milwaukee, Wis., USA</json:string><json:string>From the Research Service, Wood Veterans Administration Hospital Milwaukee, Wis., USA</json:string></affiliations></json:item><json:item><name>Joseph J. Barboriak Sc.D.</name><affiliations><json:string>From the Allergy and Medical Chest Sections, Department of Medicine and the Department of Pharmacology, The Medical College of Wisconsin Milwaukee, Wis., USA</json:string><json:string>From the Research Service, Wood Veterans Administration Hospital Milwaukee, Wis., USA</json:string></affiliations></json:item><json:item><name>Louis L. Ruff M.D.</name><affiliations><json:string>From the Allergy and Medical Chest Sections, Department of Medicine and the Department of Pharmacology, The Medical College of Wisconsin Milwaukee, Wis., USA</json:string><json:string>From the Research Service, Wood Veterans Administration Hospital Milwaukee, Wis., USA</json:string></affiliations></json:item><json:item><name>Donald P. Schlueter M.D.</name><affiliations><json:string>From the Allergy and Medical Chest Sections, Department of Medicine and the Department of Pharmacology, The Medical College of Wisconsin Milwaukee, Wis., USA</json:string><json:string>From the Research Service, Wood Veterans Administration Hospital Milwaukee, Wis., USA</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>PBS : phosphate-buffered saline</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>PDE : pigeon dropping extract</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>PS : pigeon serum</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>MIF : migration inhibition factor</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>MIS : migration inhibition studies</value></json:item></subject><language><json:string>eng</json:string></language><abstract>The immunologic and physiologic status of a group of symptomatic and asymptomatic pigeon breeders was studied in an attempt to define the immunologic events occurring in pigeon breeders' disease. Antibody activity to antigen(s) present in pigeon dropping extract (PDE) and pigeon serum (PS) was detected in the serum of both symptomatic and asymptomatic breeders. Antibody activity, however, tended to be greater in the symptomatic pigeon breeders. When subjects were challenged with PS via aerosol, serum complement activity became depressed only in asymptomatic patients. Cellular hypersensitivity to antigens present in PDE was detected in vitro in peripheral lymphocyte populations of 4 of 5 symptomatic breeders and in none of the asymptomatic breeders; cellular hypersensitivity to antigens in PS was not demonstrated in any of the individuals tested. These findings indicate that cell-mediated hypersensitivity, as well as humoral immunologic processes, may be involved in the pathogenesis of the hypersensitivity pneumonitis found in pigeon breeders.</abstract><qualityIndicators><score>5.451</score><pdfVersion>1.3</pdfVersion><pdfPageSize>468 x 684 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>5</keywordCount><abstractCharCount>1058</abstractCharCount><pdfWordCount>3627</pdfWordCount><pdfCharCount>24281</pdfCharCount><pdfPageCount>10</pdfPageCount><abstractWordCount>152</abstractWordCount></qualityIndicators><title>Immunologic events in pigeon breeders' disease</title><pii><json:string>0091-6749(74)90115-8</json:string></pii><genre><json:string>research-article</json:string></genre><serie><volume>132</volume><pages><last>911</last><first>907</first></pages><genre></genre><language><json:string>unknown</json:string></language><title>Proc. Soc. Exp. Biol. Med</title></serie><host><volume>53</volume><pii><json:string>S0091-6749(00)X0220-5</json:string></pii><pages><last>328</last><first>319</first></pages><conference><json:item><name>American Academy of Allergy, Thirty-first Annual Meeting, Town and Country Hotel, San Diego, Calif. 19750215 19750219</name></json:item></conference><issn><json:string>0091-6749</json:string></issn><issue>6</issue><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><title>The Journal of Allergy and Clinical Immunology</title><publicationDate>1974</publicationDate></host><categories><wos><json:string>ALLERGY</json:string><json:string>IMMUNOLOGY</json:string></wos></categories><publicationDate>1973</publicationDate><copyrightDate>1974</copyrightDate><doi><json:string>10.1016/0091-6749(74)90115-8</json:string></doi><id>87BA6495D7936A90F8292D197CCEF2A8798C2F08</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/87BA6495D7936A90F8292D197CCEF2A8798C2F08/fulltext/pdf</uri></json:item><json:item><original>true</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/87BA6495D7936A90F8292D197CCEF2A8798C2F08/fulltext/txt</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/87BA6495D7936A90F8292D197CCEF2A8798C2F08/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/87BA6495D7936A90F8292D197CCEF2A8798C2F08/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a">Immunologic events in pigeon breeders' disease</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>ELSEVIER</publisher><availability><p>ELSEVIER</p></availability><date>1974</date></publicationStmt><notesStmt><note>Supported by Specialized Center of Research (SCOR) Grant No. HL15389 from the National Heart and Lung Institutes, Training Grant No. AI316 from the National Institute of Allergy and Infectious Diseases, Clinical Research Grant No. MO58 from the National Institutes of Health, and a grant in memory of William Heller, Sr.</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a">Immunologic events in pigeon breeders' disease</title><author><persName><forename type="first">Vernon L.</forename><surname>Moore</surname></persName><roleName type="degree">Ph.D.</roleName><affiliation>From the Allergy and Medical Chest Sections, Department of Medicine and the Department of Pharmacology, The Medical College of Wisconsin Milwaukee, Wis., USA</affiliation><affiliation>From the Research Service, Wood Veterans Administration Hospital Milwaukee, Wis., USA</affiliation><affiliation>Reprint requests to: Vernon L. Moore, Ph.D., Research Service/151, VA Center, Wood, Wis. 53193.</affiliation></author><author><persName><forename type="first">Jordan N.</forename><surname>Fink</surname></persName><roleName type="degree">M.D.</roleName><affiliation>From the Allergy and Medical Chest Sections, Department of Medicine and the Department of Pharmacology, The Medical College of Wisconsin Milwaukee, Wis., USA</affiliation><affiliation>From the Research Service, Wood Veterans Administration Hospital Milwaukee, Wis., USA</affiliation></author><author><persName><forename type="first">Joseph J.</forename><surname>Barboriak</surname></persName><roleName type="degree">Sc.D.</roleName><affiliation>From the Allergy and Medical Chest Sections, Department of Medicine and the Department of Pharmacology, The Medical College of Wisconsin Milwaukee, Wis., USA</affiliation><affiliation>From the Research Service, Wood Veterans Administration Hospital Milwaukee, Wis., USA</affiliation></author><author><persName><forename type="first">Louis L.</forename><surname>Ruff</surname></persName><roleName type="degree">M.D.</roleName><affiliation>From the Allergy and Medical Chest Sections, Department of Medicine and the Department of Pharmacology, The Medical College of Wisconsin Milwaukee, Wis., USA</affiliation><affiliation>From the Research Service, Wood Veterans Administration Hospital Milwaukee, Wis., USA</affiliation></author><author><persName><forename type="first">Donald P.</forename><surname>Schlueter</surname></persName><roleName type="degree">M.D.</roleName><affiliation>From the Allergy and Medical Chest Sections, Department of Medicine and the Department of Pharmacology, The Medical College of Wisconsin Milwaukee, Wis., USA</affiliation><affiliation>From the Research Service, Wood Veterans Administration Hospital Milwaukee, Wis., USA</affiliation></author></analytic><monogr><title level="j">The Journal of Allergy and Clinical Immunology</title><title level="j" type="abbrev">YMAI</title><idno type="pISSN">0091-6749</idno><idno type="PII">S0091-6749(00)X0220-5</idno><meeting><addName>American Academy of Allergy, Thirty-first Annual Meeting, Town and Country Hotel, San Diego, Calif.</addName><date>19750215</date><date>19750219</date></meeting><imprint><publisher>ELSEVIER</publisher><date type="published" when="1973"></date><biblScope unit="volume">53</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="319">319</biblScope><biblScope unit="page" to="328">328</biblScope></imprint></monogr><idno type="istex">87BA6495D7936A90F8292D197CCEF2A8798C2F08</idno><idno type="DOI">10.1016/0091-6749(74)90115-8</idno><idno type="PII">0091-6749(74)90115-8</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1974</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>The immunologic and physiologic status of a group of symptomatic and asymptomatic pigeon breeders was studied in an attempt to define the immunologic events occurring in pigeon breeders' disease. Antibody activity to antigen(s) present in pigeon dropping extract (PDE) and pigeon serum (PS) was detected in the serum of both symptomatic and asymptomatic breeders. Antibody activity, however, tended to be greater in the symptomatic pigeon breeders. When subjects were challenged with PS via aerosol, serum complement activity became depressed only in asymptomatic patients. Cellular hypersensitivity to antigens present in PDE was detected in vitro in peripheral lymphocyte populations of 4 of 5 symptomatic breeders and in none of the asymptomatic breeders; cellular hypersensitivity to antigens in PS was not demonstrated in any of the individuals tested. These findings indicate that cell-mediated hypersensitivity, as well as humoral immunologic processes, may be involved in the pathogenesis of the hypersensitivity pneumonitis found in pigeon breeders.</p></abstract><textClass><keywords scheme="keyword"><list><head>Abbreviations</head><item><term>PBS</term><term>phosphate-buffered saline</term></item><item><term>PDE</term><term>pigeon dropping extract</term></item><item><term>PS</term><term>pigeon serum</term></item><item><term>MIF</term><term>migration inhibition factor</term></item><item><term>MIS</term><term>migration inhibition studies</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1973-08-28">Received</change><change when="1973">Published</change></revisionDesc></teiHeader></istex:fulltextTEI></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla"><item-info><jid>YMAI</jid><aid>74901158</aid><ce:pii>0091-6749(74)90115-8</ce:pii><ce:doi>10.1016/0091-6749(74)90115-8</ce:doi><ce:copyright type="unknown" year="1974"></ce:copyright></item-info><head><ce:article-footnote><ce:label>☆</ce:label><ce:note-para>Supported by Specialized Center of Research (SCOR) Grant No. HL15389 from the National Heart and Lung Institutes, Training Grant No. AI316 from the National Institute of Allergy and Infectious Diseases, Clinical Research Grant No. MO58 from the National Institutes of Health, and a grant in memory of William Heller, Sr.</ce:note-para></ce:article-footnote><ce:title>Immunologic events in pigeon breeders' disease</ce:title><ce:author-group><ce:author><ce:given-name>Vernon L.</ce:given-name><ce:surname>Moore</ce:surname><ce:degrees>Ph.D.</ce:degrees><ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF2"><ce:sup>b</ce:sup></ce:cross-ref><ce:cross-ref refid="COR1"><ce:sup>∗</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Jordan N.</ce:given-name><ce:surname>Fink</ce:surname><ce:degrees>M.D.</ce:degrees><ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF2"><ce:sup>b</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Joseph J.</ce:given-name><ce:surname>Barboriak</ce:surname><ce:degrees>Sc.D.</ce:degrees><ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF2"><ce:sup>b</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Louis L.</ce:given-name><ce:surname>Ruff</ce:surname><ce:degrees>M.D.</ce:degrees><ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF2"><ce:sup>b</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Donald P.</ce:given-name><ce:surname>Schlueter</ce:surname><ce:degrees>M.D.</ce:degrees><ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF2"><ce:sup>b</ce:sup></ce:cross-ref></ce:author><ce:affiliation id="AFF1"><ce:label>a</ce:label><ce:textfn>From the Allergy and Medical Chest Sections, Department of Medicine and the Department of Pharmacology, The Medical College of Wisconsin Milwaukee, Wis., USA</ce:textfn></ce:affiliation><ce:affiliation id="AFF2"><ce:label>b</ce:label><ce:textfn>From the Research Service, Wood Veterans Administration Hospital Milwaukee, Wis., USA</ce:textfn></ce:affiliation><ce:correspondence id="COR1"><ce:label>∗</ce:label><ce:text>Reprint requests to: Vernon L. Moore, Ph.D., Research Service/151, VA Center, Wood, Wis. 53193.</ce:text></ce:correspondence></ce:author-group><ce:date-received day="28" month="8" year="1973"></ce:date-received><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>The immunologic and physiologic status of a group of symptomatic and asymptomatic pigeon breeders was studied in an attempt to define the immunologic events occurring in pigeon breeders' disease. Antibody activity to antigen(s) present in pigeon dropping extract (PDE) and pigeon serum (PS) was detected in the serum of both symptomatic and asymptomatic breeders. Antibody activity, however, tended to be greater in the symptomatic pigeon breeders. When subjects were challenged with PS via aerosol, serum complement activity became depressed only in asymptomatic patients. Cellular hypersensitivity to antigens present in PDE was detected in vitro in peripheral lymphocyte populations of 4 of 5 symptomatic breeders and in none of the asymptomatic breeders; cellular hypersensitivity to antigens in PS was not demonstrated in any of the individuals tested. These findings indicate that cell-mediated hypersensitivity, as well as humoral immunologic processes, may be involved in the pathogenesis of the hypersensitivity pneumonitis found in pigeon breeders.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords class="abr"><ce:section-title>Abbreviations</ce:section-title><ce:keyword><ce:text>PBS</ce:text><ce:keyword><ce:text>phosphate-buffered saline</ce:text></ce:keyword></ce:keyword><ce:keyword><ce:text>PDE</ce:text><ce:keyword><ce:text>pigeon dropping extract</ce:text></ce:keyword></ce:keyword><ce:keyword><ce:text>PS</ce:text><ce:keyword><ce:text>pigeon serum</ce:text></ce:keyword></ce:keyword><ce:keyword><ce:text>MIF</ce:text><ce:keyword><ce:text>migration inhibition factor</ce:text></ce:keyword></ce:keyword><ce:keyword><ce:text>MIS</ce:text><ce:keyword><ce:text>migration inhibition studies</ce:text></ce:keyword></ce:keyword></ce:keywords></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Immunologic events in pigeon breeders' disease</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Immunologic events in pigeon breeders' disease</title></titleInfo><name type="personal"><namePart type="given">Vernon L.</namePart><namePart type="family">Moore</namePart><namePart type="termsOfAddress">Ph.D.</namePart><affiliation>From the Allergy and Medical Chest Sections, Department of Medicine and the Department of Pharmacology, The Medical College of Wisconsin Milwaukee, Wis., USA</affiliation><affiliation>From the Research Service, Wood Veterans Administration Hospital Milwaukee, Wis., USA</affiliation><affiliation>Reprint requests to: Vernon L. Moore, Ph.D., Research Service/151, VA Center, Wood, Wis. 53193.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jordan N.</namePart><namePart type="family">Fink</namePart><namePart type="termsOfAddress">M.D.</namePart><affiliation>From the Allergy and Medical Chest Sections, Department of Medicine and the Department of Pharmacology, The Medical College of Wisconsin Milwaukee, Wis., USA</affiliation><affiliation>From the Research Service, Wood Veterans Administration Hospital Milwaukee, Wis., USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Joseph J.</namePart><namePart type="family">Barboriak</namePart><namePart type="termsOfAddress">Sc.D.</namePart><affiliation>From the Allergy and Medical Chest Sections, Department of Medicine and the Department of Pharmacology, The Medical College of Wisconsin Milwaukee, Wis., USA</affiliation><affiliation>From the Research Service, Wood Veterans Administration Hospital Milwaukee, Wis., USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Louis L.</namePart><namePart type="family">Ruff</namePart><namePart type="termsOfAddress">M.D.</namePart><affiliation>From the Allergy and Medical Chest Sections, Department of Medicine and the Department of Pharmacology, The Medical College of Wisconsin Milwaukee, Wis., USA</affiliation><affiliation>From the Research Service, Wood Veterans Administration Hospital Milwaukee, Wis., USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Donald P.</namePart><namePart type="family">Schlueter</namePart><namePart type="termsOfAddress">M.D.</namePart><affiliation>From the Allergy and Medical Chest Sections, Department of Medicine and the Department of Pharmacology, The Medical College of Wisconsin Milwaukee, Wis., USA</affiliation><affiliation>From the Research Service, Wood Veterans Administration Hospital Milwaukee, Wis., USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article"></genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1973</dateIssued><dateCaptured encoding="w3cdtf">1973-08-28</dateCaptured><copyrightDate encoding="w3cdtf">1974</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">The immunologic and physiologic status of a group of symptomatic and asymptomatic pigeon breeders was studied in an attempt to define the immunologic events occurring in pigeon breeders' disease. Antibody activity to antigen(s) present in pigeon dropping extract (PDE) and pigeon serum (PS) was detected in the serum of both symptomatic and asymptomatic breeders. Antibody activity, however, tended to be greater in the symptomatic pigeon breeders. When subjects were challenged with PS via aerosol, serum complement activity became depressed only in asymptomatic patients. Cellular hypersensitivity to antigens present in PDE was detected in vitro in peripheral lymphocyte populations of 4 of 5 symptomatic breeders and in none of the asymptomatic breeders; cellular hypersensitivity to antigens in PS was not demonstrated in any of the individuals tested. These findings indicate that cell-mediated hypersensitivity, as well as humoral immunologic processes, may be involved in the pathogenesis of the hypersensitivity pneumonitis found in pigeon breeders.</abstract><note>Supported by Specialized Center of Research (SCOR) Grant No. HL15389 from the National Heart and Lung Institutes, Training Grant No. AI316 from the National Institute of Allergy and Infectious Diseases, Clinical Research Grant No. MO58 from the National Institutes of Health, and a grant in memory of William Heller, Sr.</note><subject><genre>Abbreviations</genre><topic>PBS : phosphate-buffered saline</topic><topic>PDE : pigeon dropping extract</topic><topic>PS : pigeon serum</topic><topic>MIF : migration inhibition factor</topic><topic>MIS : migration inhibition studies</topic></subject><relatedItem type="host"><titleInfo><title>The Journal of Allergy and Clinical Immunology</title></titleInfo><titleInfo type="abbreviated"><title>YMAI</title></titleInfo><name type="conference"><namePart>American Academy of Allergy, Thirty-first Annual Meeting, Town and Country Hotel, San Diego, Calif.</namePart><namePart type="date">19750215</namePart><namePart type="date" encoding="w3cdtf">19750219</namePart></name><genre type="Journal">journal</genre><originInfo><dateIssued encoding="w3cdtf">197406</dateIssued></originInfo><identifier type="ISSN">0091-6749</identifier><identifier type="PII">S0091-6749(00)X0220-5</identifier><part><date>197406</date><detail type="issue"><title>American Academy of Allergy, Thirty-first Annual Meeting, Town and Country Hotel, San Diego, Calif.</title></detail><detail type="volume"><number>53</number><caption>vol.</caption></detail><detail type="issue"><number>6</number><caption>no.</caption></detail><extent unit="issue pages"><start>A3</start><end>A31</end></extent><extent unit="issue pages"><start>A37</start><end>A64</end></extent><extent unit="issue pages"><start>319</start><end>378</end></extent><extent unit="pages"><start>319</start><end>328</end></extent></part></relatedItem><identifier type="istex">87BA6495D7936A90F8292D197CCEF2A8798C2F08</identifier><identifier type="DOI">10.1016/0091-6749(74)90115-8</identifier><identifier type="PII">0091-6749(74)90115-8</identifier><recordInfo><recordContentSource>ELSEVIER</recordContentSource></recordInfo></mods></metadata><enrichments><istex:catWosTEI uri="https://api.istex.fr/document/87BA6495D7936A90F8292D197CCEF2A8798C2F08/enrichments/catWos"><teiHeader><profileDesc><textClass><classCode scheme="WOS">ALLERGY</classCode><classCode scheme="WOS">IMMUNOLOGY</classCode></textClass></profileDesc></teiHeader></istex:catWosTEI></enrichments></istex></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Informatique/explor/ScrumV1/Data/Istex/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000958 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Corpus/biblio.hfd -nk 000958 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Informatique
|area= ScrumV1
|flux= Istex
|étape= Corpus
|type= RBID
|clé= ISTEX:87BA6495D7936A90F8292D197CCEF2A8798C2F08
|texte= Immunologic events in pigeon breeders' disease
}}
| This area was generated with Dilib version V0.6.39. |  |