Model simulation of a single oral dose of cefuroxime axetil and the related in-vitro kill kinetics against four bacterial species
Identifieur interne : 000957 ( Istex/Corpus ); précédent : 000956; suivant : 000958Model simulation of a single oral dose of cefuroxime axetil and the related in-vitro kill kinetics against four bacterial species
Auteurs : P. Silley ; D. Monsey ; A. M. HarrisSource :
- Journal of Antimicrobial Chemotherapy [ 0305-7453 ] ; 1990-01.
Abstract
An in-vitro model was shown to be capable of simulating a cefuroxime serum profile equivalent to that observed in human volunteer studies, following a single dose of 250 mg cefuroxime axetil. The model was used to carry out kill kinetic studies and showed cefuroxime to lyse the four bacterial test strains, time of onset of lysis being related to the sensitivity of the respective organisms. The more sensitive Staphylococcus aureus and Haemophilus influenzae strains were subject to a higher absolute kill and showed no regrowth over the duration of the simulated serum profile. In contrast, Proteus mirabilis and Escherichia coli showed regrowth after 4 and 5 h respectively. The kill kinetic profiles of the respective organisms are discussed in relation to the pharmacokinetic analysis of the cefuroxime serum profile.
Url:
DOI: 10.1093/jac/25.1.83
Links to Exploration step
ISTEX:E14EAA76BD80A5206181A10207F3F6E58A214599Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Model simulation of a single oral dose of cefuroxime axetil and the related in-vitro kill kinetics against four bacterial species</title><author><name sortKey="Silley, P" sort="Silley, P" uniqKey="Silley P" first="P." last="Silley">P. Silley</name><affiliation><mods:affiliation>Chemotherapy Department, Microbiology Division, Glaxo Group Research Limited, Greenford Road, Greenford UB 60HE, UK</mods:affiliation></affiliation></author><author><name sortKey="Monsey, D" sort="Monsey, D" uniqKey="Monsey D" first="D." last="Monsey">D. Monsey</name><affiliation><mods:affiliation>Chemotherapy Department, Microbiology Division, Glaxo Group Research Limited, Greenford Road, Greenford UB 60HE, UK</mods:affiliation></affiliation></author><author><name sortKey="Harris, A M" sort="Harris, A M" uniqKey="Harris A" first="A. M." last="Harris">A. M. Harris</name><affiliation><mods:affiliation>Chemotherapy Department, Microbiology Division, Glaxo Group Research Limited, Greenford Road, Greenford UB 60HE, UK</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:E14EAA76BD80A5206181A10207F3F6E58A214599</idno><date when="1990" year="1990">1990</date><idno type="doi">10.1093/jac/25.1.83</idno><idno type="url">https://api.istex.fr/document/E14EAA76BD80A5206181A10207F3F6E58A214599/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000957</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Model simulation of a single oral dose of cefuroxime axetil and the related in-vitro kill kinetics against four bacterial species</title><author><name sortKey="Silley, P" sort="Silley, P" uniqKey="Silley P" first="P." last="Silley">P. Silley</name><affiliation><mods:affiliation>Chemotherapy Department, Microbiology Division, Glaxo Group Research Limited, Greenford Road, Greenford UB 60HE, UK</mods:affiliation></affiliation></author><author><name sortKey="Monsey, D" sort="Monsey, D" uniqKey="Monsey D" first="D." last="Monsey">D. Monsey</name><affiliation><mods:affiliation>Chemotherapy Department, Microbiology Division, Glaxo Group Research Limited, Greenford Road, Greenford UB 60HE, UK</mods:affiliation></affiliation></author><author><name sortKey="Harris, A M" sort="Harris, A M" uniqKey="Harris A" first="A. M." last="Harris">A. M. Harris</name><affiliation><mods:affiliation>Chemotherapy Department, Microbiology Division, Glaxo Group Research Limited, Greenford Road, Greenford UB 60HE, UK</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Antimicrobial Chemotherapy</title><idno type="ISSN">0305-7453</idno><idno type="eISSN">1460-2091</idno><imprint><publisher>Oxford University Press</publisher><date type="published" when="1990-01">1990-01</date><biblScope unit="volume">25</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="83">83</biblScope><biblScope unit="page" to="90">90</biblScope></imprint><idno type="ISSN">0305-7453</idno></series><idno type="istex">E14EAA76BD80A5206181A10207F3F6E58A214599</idno><idno type="DOI">10.1093/jac/25.1.83</idno><idno type="ArticleID">25.1.83</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0305-7453</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">An in-vitro model was shown to be capable of simulating a cefuroxime serum profile equivalent to that observed in human volunteer studies, following a single dose of 250 mg cefuroxime axetil. The model was used to carry out kill kinetic studies and showed cefuroxime to lyse the four bacterial test strains, time of onset of lysis being related to the sensitivity of the respective organisms. The more sensitive Staphylococcus aureus and Haemophilus influenzae strains were subject to a higher absolute kill and showed no regrowth over the duration of the simulated serum profile. In contrast, Proteus mirabilis and Escherichia coli showed regrowth after 4 and 5 h respectively. The kill kinetic profiles of the respective organisms are discussed in relation to the pharmacokinetic analysis of the cefuroxime serum profile.</div></front></TEI><istex><corpusName>oup</corpusName><author><json:item><name>P. Silley</name><affiliations><json:string>Chemotherapy Department, Microbiology Division, Glaxo Group Research Limited, Greenford Road, Greenford UB 60HE, UK</json:string></affiliations></json:item><json:item><name>D. Monsey</name><affiliations><json:string>Chemotherapy Department, Microbiology Division, Glaxo Group Research Limited, Greenford Road, Greenford UB 60HE, UK</json:string></affiliations></json:item><json:item><name>A. M. Harris</name><affiliations><json:string>Chemotherapy Department, Microbiology Division, Glaxo Group Research Limited, Greenford Road, Greenford UB 60HE, UK</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Original articles</value></json:item></subject><articleId><json:string>25.1.83</json:string></articleId><language><json:string>eng</json:string></language><abstract>An in-vitro model was shown to be capable of simulating a cefuroxime serum profile equivalent to that observed in human volunteer studies, following a single dose of 250 mg cefuroxime axetil. The model was used to carry out kill kinetic studies and showed cefuroxime to lyse the four bacterial test strains, time of onset of lysis being related to the sensitivity of the respective organisms. The more sensitive Staphylococcus aureus and Haemophilus influenzae strains were subject to a higher absolute kill and showed no regrowth over the duration of the simulated serum profile. In contrast, Proteus mirabilis and Escherichia coli showed regrowth after 4 and 5 h respectively. The kill kinetic profiles of the respective organisms are discussed in relation to the pharmacokinetic analysis of the cefuroxime serum profile.</abstract><qualityIndicators><score>4.995</score><pdfVersion>1.5</pdfVersion><pdfPageSize>628 x 811 pts</pdfPageSize><refBibsNative>false</refBibsNative><keywordCount>1</keywordCount><abstractCharCount>823</abstractCharCount><pdfWordCount>2447</pdfWordCount><pdfCharCount>14639</pdfCharCount><pdfPageCount>8</pdfPageCount><abstractWordCount>129</abstractWordCount></qualityIndicators><title>Model simulation of a single oral dose of cefuroxime axetil and the related in-vitro kill kinetics against four bacterial species</title><genre.original><json:string>research-article</json:string></genre.original><genre><json:string>research-article</json:string></genre><host><volume>25</volume><publisherId><json:string>jac</json:string></publisherId><pages><last>90</last><first>83</first></pages><issn><json:string>0305-7453</json:string></issn><issue>1</issue><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1460-2091</json:string></eissn><title>Journal of Antimicrobial Chemotherapy</title></host><categories><wos><json:string>INFECTIOUS DISEASES</json:string><json:string>PHARMACOLOGY & PHARMACY</json:string><json:string>MICROBIOLOGY</json:string></wos></categories><publicationDate>1990</publicationDate><copyrightDate>1990</copyrightDate><doi><json:string>10.1093/jac/25.1.83</json:string></doi><id>E14EAA76BD80A5206181A10207F3F6E58A214599</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/E14EAA76BD80A5206181A10207F3F6E58A214599/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/E14EAA76BD80A5206181A10207F3F6E58A214599/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/E14EAA76BD80A5206181A10207F3F6E58A214599/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a">Model simulation of a single oral dose of cefuroxime axetil and the related in-vitro kill kinetics against four bacterial species</title><respStmt xml:id="ISTEX-API" resp="Références bibliographiques récupérées via GROBID" name="ISTEX-API (INIST-CNRS)"></respStmt><respStmt xml:id="ISTEX-API" resp="Références bibliographiques récupérées via GROBID" name="ISTEX-API (INIST-CNRS)"></respStmt></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Oxford University Press</publisher><availability><p>OUP</p></availability><date>1990</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a">Model simulation of a single oral dose of cefuroxime axetil and the related in-vitro kill kinetics against four bacterial species</title><author><persName><forename type="first">P.</forename><surname>Silley</surname></persName><affiliation>Chemotherapy Department, Microbiology Division, Glaxo Group Research Limited, Greenford Road, Greenford UB 60HE, UK</affiliation></author><author><persName><forename type="first">D.</forename><surname>Monsey</surname></persName><affiliation>Chemotherapy Department, Microbiology Division, Glaxo Group Research Limited, Greenford Road, Greenford UB 60HE, UK</affiliation></author><author><persName><forename type="first">A. M.</forename><surname>Harris</surname></persName><affiliation>Chemotherapy Department, Microbiology Division, Glaxo Group Research Limited, Greenford Road, Greenford UB 60HE, UK</affiliation></author></analytic><monogr><title level="j">Journal of Antimicrobial Chemotherapy</title><idno type="pISSN">0305-7453</idno><idno type="eISSN">1460-2091</idno><imprint><publisher>Oxford University Press</publisher><date type="published" when="1990-01"></date><biblScope unit="volume">25</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="83">83</biblScope><biblScope unit="page" to="90">90</biblScope></imprint></monogr><idno type="istex">E14EAA76BD80A5206181A10207F3F6E58A214599</idno><idno type="DOI">10.1093/jac/25.1.83</idno><idno type="ArticleID">25.1.83</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1990</date></creation><langUsage><language ident="en">en</language></langUsage><abstract><p>An in-vitro model was shown to be capable of simulating a cefuroxime serum profile equivalent to that observed in human volunteer studies, following a single dose of 250 mg cefuroxime axetil. The model was used to carry out kill kinetic studies and showed cefuroxime to lyse the four bacterial test strains, time of onset of lysis being related to the sensitivity of the respective organisms. The more sensitive Staphylococcus aureus and Haemophilus influenzae strains were subject to a higher absolute kill and showed no regrowth over the duration of the simulated serum profile. In contrast, Proteus mirabilis and Escherichia coli showed regrowth after 4 and 5 h respectively. The kill kinetic profiles of the respective organisms are discussed in relation to the pharmacokinetic analysis of the cefuroxime serum profile.</p></abstract><textClass><keywords scheme="keyword"><list><item><term>Original articles</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1990-01">Published</change><change xml:id="refBibs-istex" who="#ISTEX-API" when="2016-3-15">References added</change><change xml:id="refBibs-istex" who="#ISTEX-API" when="2016-3-22">References added</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/E14EAA76BD80A5206181A10207F3F6E58A214599/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="corpus oup" wicri:toSee="no header"><istex:docType PUBLIC="-//NLM//DTD Journal Publishing DTD v2.3 20070202//EN" URI="journalpublishing.dtd" name="istex:docType"></istex:docType><istex:document><article article-type="research-article"><front><journal-meta><journal-id journal-id-type="hwp">jac</journal-id><journal-id journal-id-type="publisher-id">jac</journal-id><journal-id journal-id-type="pmc">jac</journal-id><journal-title>Journal of Antimicrobial Chemotherapy</journal-title><issn pub-type="epub">1460-2091</issn><issn pub-type="ppub">0305-7453</issn><publisher><publisher-name>Oxford University Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">25.1.83</article-id><article-id pub-id-type="doi">10.1093/jac/25.1.83</article-id><article-categories><subj-group><subject>Original articles</subject></subj-group></article-categories><title-group><article-title>Model simulation of a single oral dose of cefuroxime axetil and the related in-vitro kill kinetics against four bacterial species</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Silley</surname><given-names>P.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Monsey</surname><given-names>D.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Harris</surname><given-names>A. M.</given-names></name></contrib><aff><institution>Chemotherapy Department, Microbiology Division, Glaxo Group Research Limited</institution> <addr-line>Greenford Road, Greenford UB 60HE, UK</addr-line></aff></contrib-group><pub-date pub-type="ppub"><month>1</month><year>1990</year></pub-date><volume>25</volume><issue>1</issue><fpage>83</fpage><lpage>90</lpage><history><date date-type="received"><day>30</day><month>3</month><year>1989</year></date><date date-type="accepted"><day>30</day><month>8</month><year>1989</year></date></history><copyright-statement>© 1990 The British Society for Antimicrobial Chemotherapy</copyright-statement><copyright-year>1990</copyright-year><abstract><p>An in-vitro model was shown to be capable of simulating a cefuroxime serum profile equivalent to that observed in human volunteer studies, following a single dose of 250 mg cefuroxime axetil. The model was used to carry out kill kinetic studies and showed cefuroxime to lyse the four bacterial test strains, time of onset of lysis being related to the sensitivity of the respective organisms. The more sensitive <italic>Staphylococcus aureus</italic> and <italic>Haemophilus influenzae</italic> strains were subject to a higher absolute kill and showed no regrowth over the duration of the simulated serum profile. In contrast, <italic>Proteus mirabilis</italic> and <italic>Escherichia coli</italic> showed regrowth after 4 and 5 h respectively. The kill kinetic profiles of the respective organisms are discussed in relation to the pharmacokinetic analysis of the cefuroxime serum profile.</p></abstract></article-meta></front></article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Model simulation of a single oral dose of cefuroxime axetil and the related in-vitro kill kinetics against four bacterial species</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Model simulation of a single oral dose of cefuroxime axetil and the related in-vitro kill kinetics against four bacterial species</title></titleInfo><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Silley</namePart><affiliation>Chemotherapy Department, Microbiology Division, Glaxo Group Research Limited, Greenford Road, Greenford UB 60HE, UK</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D.</namePart><namePart type="family">Monsey</namePart><affiliation>Chemotherapy Department, Microbiology Division, Glaxo Group Research Limited, Greenford Road, Greenford UB 60HE, UK</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A. M.</namePart><namePart type="family">Harris</namePart><affiliation>Chemotherapy Department, Microbiology Division, Glaxo Group Research Limited, Greenford Road, Greenford UB 60HE, UK</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="research-article"></genre><subject><topic>Original articles</topic></subject><originInfo><publisher>Oxford University Press</publisher><dateIssued encoding="w3cdtf">1990-01</dateIssued><copyrightDate encoding="w3cdtf">1990</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract>An in-vitro model was shown to be capable of simulating a cefuroxime serum profile equivalent to that observed in human volunteer studies, following a single dose of 250 mg cefuroxime axetil. The model was used to carry out kill kinetic studies and showed cefuroxime to lyse the four bacterial test strains, time of onset of lysis being related to the sensitivity of the respective organisms. The more sensitive Staphylococcus aureus and Haemophilus influenzae strains were subject to a higher absolute kill and showed no regrowth over the duration of the simulated serum profile. In contrast, Proteus mirabilis and Escherichia coli showed regrowth after 4 and 5 h respectively. The kill kinetic profiles of the respective organisms are discussed in relation to the pharmacokinetic analysis of the cefuroxime serum profile.</abstract><relatedItem type="host"><titleInfo><title>Journal of Antimicrobial Chemotherapy</title></titleInfo><genre type="Journal">journal</genre><identifier type="ISSN">0305-7453</identifier><identifier type="eISSN">1460-2091</identifier><identifier type="PublisherID">jac</identifier><identifier type="PublisherID-hwp">jac</identifier><part><date>1990</date><detail type="volume"><caption>vol.</caption><number>25</number></detail><detail type="issue"><caption>no.</caption><number>1</number></detail><extent unit="pages"><start>83</start><end>90</end></extent></part></relatedItem><identifier type="istex">E14EAA76BD80A5206181A10207F3F6E58A214599</identifier><identifier type="DOI">10.1093/jac/25.1.83</identifier><identifier type="ArticleID">25.1.83</identifier><accessCondition type="use and reproduction" contentType="copyright">© 1990 The British Society for Antimicrobial Chemotherapy</accessCondition><recordInfo><recordContentSource>OUP</recordContentSource></recordInfo></mods></metadata><annexes><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/E14EAA76BD80A5206181A10207F3F6E58A214599/annexes/pdf</uri></json:item></annexes><enrichments><istex:catWosTEI uri="https://api.istex.fr/document/E14EAA76BD80A5206181A10207F3F6E58A214599/enrichments/catWos"><teiHeader><profileDesc><textClass><classCode scheme="WOS">INFECTIOUS DISEASES</classCode><classCode scheme="WOS">PHARMACOLOGY & PHARMACY</classCode><classCode scheme="WOS">MICROBIOLOGY</classCode></textClass></profileDesc></teiHeader></istex:catWosTEI></enrichments><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Informatique/explor/ScrumV1/Data/Istex/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000957 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Corpus/biblio.hfd -nk 000957 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Informatique
|area= ScrumV1
|flux= Istex
|étape= Corpus
|type= RBID
|clé= ISTEX:E14EAA76BD80A5206181A10207F3F6E58A214599
|texte= Model simulation of a single oral dose of cefuroxime axetil and the related in-vitro kill kinetics against four bacterial species
}}
| This area was generated with Dilib version V0.6.39. |  |