Mechanism of trimethylamine-induced inhibition of macromolecular synthesis by mouse embryos in culture
Identifieur interne : 000081 ( Istex/Corpus ); précédent : 000080; suivant : 000082Mechanism of trimethylamine-induced inhibition of macromolecular synthesis by mouse embryos in culture
Auteurs : I. Guest ; D. G. Cyr ; D. R. VarmaSource :
- Food and Chemical Toxicology [ 0278-6915 ] ; 1993.
Abstract
The effects of trimethylamine (TMA) on uptake mechanisms and lysosomal function were studied in mouse embryos, isolated yolk sacs and limb buds. TMA at 0.75 mm did not inhibit uptake of [14C]sucrose by yolk sacs of day 9 embryos or by day 15 isolated yolk sacs but did inhibit uptake of 125I-labelled bovine serum albumin ([125I]BSA) by day 15 isolated yolk sacs. Concentrations of TMA up to 2.5 mm did not inhibit lysosomal degradation of [125I]BSA by isolated yolk sacs, as judged by the release of trichloroacetic acid (TCA)-soluble radioactivity into the culture media. The inhibition of [125I]BSA uptake induced by TMA was reversible on removal of TMA. When day 8 embryos were cultured in serum containing [3H]leucine-labelled proteins, uptake and incorporation of radioactivity in 0.75 mm TMA-treated embryos was 47 and 44%, respectively, of that in untreated controls. TMA at 0.75 mm did not inhibit the uptake and incorporation of free [3H]leucine into embryonic protein nor the amount of free [3H]leucine taken up or incorporated into protein by day 12 isolated limb buds. It is concluded that the reduced macromolecular synthesis in embryos exposed to TMA is due to an inhibition of receptor-medicated uptake of nutrients by the yolk sac.
Url:
DOI: 10.1016/0278-6915(94)90075-2
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Mechanism of trimethylamine-induced inhibition of macromolecular synthesis by mouse embryos in culture</title><author><name sortKey="Guest, I" sort="Guest, I" uniqKey="Guest I" first="I." last="Guest">I. Guest</name><affiliation><mods:affiliation>Department of Pharmacology and Therapeutics, McGill University, 3655 Drummond Street, Montreal, Canada H3G 1Y6</mods:affiliation></affiliation></author><author><name sortKey="Cyr, D G" sort="Cyr, D G" uniqKey="Cyr D" first="D. G." last="Cyr">D. G. Cyr</name><affiliation><mods:affiliation>Department of Pharmacology and Therapeutics, McGill University, 3655 Drummond Street, Montreal, Canada H3G 1Y6</mods:affiliation></affiliation></author><author><name sortKey="Varma, D R" sort="Varma, D R" uniqKey="Varma D" first="D. R." last="Varma">D. R. Varma</name><affiliation><mods:affiliation>Department of Pharmacology and Therapeutics, McGill University, 3655 Drummond Street, Montreal, Canada H3G 1Y6</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:D6962CA9DF95F8F2CD58C6A82AF9E74AA56C7F36</idno><date when="1994" year="1994">1994</date><idno type="doi">10.1016/0278-6915(94)90075-2</idno><idno type="url">https://api.istex.fr/document/D6962CA9DF95F8F2CD58C6A82AF9E74AA56C7F36/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000081</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Mechanism of trimethylamine-induced inhibition of macromolecular synthesis by mouse embryos in culture</title><author><name sortKey="Guest, I" sort="Guest, I" uniqKey="Guest I" first="I." last="Guest">I. Guest</name><affiliation><mods:affiliation>Department of Pharmacology and Therapeutics, McGill University, 3655 Drummond Street, Montreal, Canada H3G 1Y6</mods:affiliation></affiliation></author><author><name sortKey="Cyr, D G" sort="Cyr, D G" uniqKey="Cyr D" first="D. G." last="Cyr">D. G. Cyr</name><affiliation><mods:affiliation>Department of Pharmacology and Therapeutics, McGill University, 3655 Drummond Street, Montreal, Canada H3G 1Y6</mods:affiliation></affiliation></author><author><name sortKey="Varma, D R" sort="Varma, D R" uniqKey="Varma D" first="D. R." last="Varma">D. R. Varma</name><affiliation><mods:affiliation>Department of Pharmacology and Therapeutics, McGill University, 3655 Drummond Street, Montreal, Canada H3G 1Y6</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Food and Chemical Toxicology</title><title level="j" type="abbrev">FCT</title><idno type="ISSN">0278-6915</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1993">1993</date><biblScope unit="volume">32</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="365">365</biblScope><biblScope unit="page" to="371">371</biblScope></imprint><idno type="ISSN">0278-6915</idno></series><idno type="istex">D6962CA9DF95F8F2CD58C6A82AF9E74AA56C7F36</idno><idno type="DOI">10.1016/0278-6915(94)90075-2</idno><idno type="PII">0278-6915(94)90075-2</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0278-6915</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The effects of trimethylamine (TMA) on uptake mechanisms and lysosomal function were studied in mouse embryos, isolated yolk sacs and limb buds. TMA at 0.75 mm did not inhibit uptake of [14C]sucrose by yolk sacs of day 9 embryos or by day 15 isolated yolk sacs but did inhibit uptake of 125I-labelled bovine serum albumin ([125I]BSA) by day 15 isolated yolk sacs. Concentrations of TMA up to 2.5 mm did not inhibit lysosomal degradation of [125I]BSA by isolated yolk sacs, as judged by the release of trichloroacetic acid (TCA)-soluble radioactivity into the culture media. The inhibition of [125I]BSA uptake induced by TMA was reversible on removal of TMA. When day 8 embryos were cultured in serum containing [3H]leucine-labelled proteins, uptake and incorporation of radioactivity in 0.75 mm TMA-treated embryos was 47 and 44%, respectively, of that in untreated controls. TMA at 0.75 mm did not inhibit the uptake and incorporation of free [3H]leucine into embryonic protein nor the amount of free [3H]leucine taken up or incorporated into protein by day 12 isolated limb buds. It is concluded that the reduced macromolecular synthesis in embryos exposed to TMA is due to an inhibition of receptor-medicated uptake of nutrients by the yolk sac.</div></front></TEI><istex><corpusName>elsevier</corpusName><author><json:item><name>I. Guest</name><affiliations><json:string>Department of Pharmacology and Therapeutics, McGill University, 3655 Drummond Street, Montreal, Canada H3G 1Y6</json:string></affiliations></json:item><json:item><name>D.G. Cyr</name><affiliations><json:string>Department of Pharmacology and Therapeutics, McGill University, 3655 Drummond Street, Montreal, Canada H3G 1Y6</json:string></affiliations></json:item><json:item><name>D.R. Varma</name><affiliations><json:string>Department of Pharmacology and Therapeutics, McGill University, 3655 Drummond Street, Montreal, Canada H3G 1Y6</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>BSA = bovine serum albumin</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>IGF = insulin-like growth factor</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>TCA = trichloroacetic acid</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>TMA = trimethylamine</value></json:item></subject><language><json:string>eng</json:string></language><abstract>The effects of trimethylamine (TMA) on uptake mechanisms and lysosomal function were studied in mouse embryos, isolated yolk sacs and limb buds. TMA at 0.75 mm did not inhibit uptake of [14C]sucrose by yolk sacs of day 9 embryos or by day 15 isolated yolk sacs but did inhibit uptake of 125I-labelled bovine serum albumin ([125I]BSA) by day 15 isolated yolk sacs. Concentrations of TMA up to 2.5 mm did not inhibit lysosomal degradation of [125I]BSA by isolated yolk sacs, as judged by the release of trichloroacetic acid (TCA)-soluble radioactivity into the culture media. The inhibition of [125I]BSA uptake induced by TMA was reversible on removal of TMA. When day 8 embryos were cultured in serum containing [3H]leucine-labelled proteins, uptake and incorporation of radioactivity in 0.75 mm TMA-treated embryos was 47 and 44%, respectively, of that in untreated controls. TMA at 0.75 mm did not inhibit the uptake and incorporation of free [3H]leucine into embryonic protein nor the amount of free [3H]leucine taken up or incorporated into protein by day 12 isolated limb buds. It is concluded that the reduced macromolecular synthesis in embryos exposed to TMA is due to an inhibition of receptor-medicated uptake of nutrients by the yolk sac.</abstract><qualityIndicators><score>7.144</score><pdfVersion>1.2</pdfVersion><pdfPageSize>533 x 764 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>4</keywordCount><abstractCharCount>1248</abstractCharCount><pdfWordCount>4732</pdfWordCount><pdfCharCount>28056</pdfCharCount><pdfPageCount>7</pdfPageCount><abstractWordCount>201</abstractWordCount></qualityIndicators><title>Mechanism of trimethylamine-induced inhibition of macromolecular synthesis by mouse embryos in culture</title><pii><json:string>0278-6915(94)90075-2</json:string></pii><genre><json:string>research-article</json:string></genre><serie><pages><last>121</last><first>109</first></pages><genre></genre><language><json:string>unknown</json:string></language><title>I. Relative contributions of free amino acids and of proteins</title></serie><host><volume>32</volume><pii><json:string>S0278-6915(00)X0192-5</json:string></pii><pages><last>371</last><first>365</first></pages><issn><json:string>0278-6915</json:string></issn><issue>4</issue><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><title>Food and Chemical Toxicology</title><publicationDate>1994</publicationDate></host><categories><wos><json:string>TOXICOLOGY</json:string><json:string>TRANSPLANTATION</json:string><json:string>FOOD SCIENCE & TECHNOLOGY</json:string></wos></categories><publicationDate>1993</publicationDate><copyrightDate>1994</copyrightDate><doi><json:string>10.1016/0278-6915(94)90075-2</json:string></doi><id>D6962CA9DF95F8F2CD58C6A82AF9E74AA56C7F36</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/D6962CA9DF95F8F2CD58C6A82AF9E74AA56C7F36/fulltext/pdf</uri></json:item><json:item><original>true</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/D6962CA9DF95F8F2CD58C6A82AF9E74AA56C7F36/fulltext/txt</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/D6962CA9DF95F8F2CD58C6A82AF9E74AA56C7F36/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/D6962CA9DF95F8F2CD58C6A82AF9E74AA56C7F36/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a">Mechanism of trimethylamine-induced inhibition of macromolecular synthesis by mouse embryos in culture</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>ELSEVIER</publisher><availability><p>ELSEVIER</p></availability><date>1994</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a">Mechanism of trimethylamine-induced inhibition of macromolecular synthesis by mouse embryos in culture</title><author><persName><forename type="first">I.</forename><surname>Guest</surname></persName><affiliation>Department of Pharmacology and Therapeutics, McGill University, 3655 Drummond Street, Montreal, Canada H3G 1Y6</affiliation></author><author><persName><forename type="first">D.G.</forename><surname>Cyr</surname></persName><affiliation>Department of Pharmacology and Therapeutics, McGill University, 3655 Drummond Street, Montreal, Canada H3G 1Y6</affiliation></author><author><persName><forename type="first">D.R.</forename><surname>Varma</surname></persName><affiliation>To whom correspondence should be addressed.</affiliation><affiliation>Department of Pharmacology and Therapeutics, McGill University, 3655 Drummond Street, Montreal, Canada H3G 1Y6</affiliation></author></analytic><monogr><title level="j">Food and Chemical Toxicology</title><title level="j" type="abbrev">FCT</title><idno type="pISSN">0278-6915</idno><idno type="PII">S0278-6915(00)X0192-5</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1993"></date><biblScope unit="volume">32</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="365">365</biblScope><biblScope unit="page" to="371">371</biblScope></imprint></monogr><idno type="istex">D6962CA9DF95F8F2CD58C6A82AF9E74AA56C7F36</idno><idno type="DOI">10.1016/0278-6915(94)90075-2</idno><idno type="PII">0278-6915(94)90075-2</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1994</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>The effects of trimethylamine (TMA) on uptake mechanisms and lysosomal function were studied in mouse embryos, isolated yolk sacs and limb buds. TMA at 0.75 mm did not inhibit uptake of [14C]sucrose by yolk sacs of day 9 embryos or by day 15 isolated yolk sacs but did inhibit uptake of 125I-labelled bovine serum albumin ([125I]BSA) by day 15 isolated yolk sacs. Concentrations of TMA up to 2.5 mm did not inhibit lysosomal degradation of [125I]BSA by isolated yolk sacs, as judged by the release of trichloroacetic acid (TCA)-soluble radioactivity into the culture media. The inhibition of [125I]BSA uptake induced by TMA was reversible on removal of TMA. When day 8 embryos were cultured in serum containing [3H]leucine-labelled proteins, uptake and incorporation of radioactivity in 0.75 mm TMA-treated embryos was 47 and 44%, respectively, of that in untreated controls. TMA at 0.75 mm did not inhibit the uptake and incorporation of free [3H]leucine into embryonic protein nor the amount of free [3H]leucine taken up or incorporated into protein by day 12 isolated limb buds. It is concluded that the reduced macromolecular synthesis in embryos exposed to TMA is due to an inhibition of receptor-medicated uptake of nutrients by the yolk sac.</p></abstract><textClass><keywords scheme="keyword"><list><head>Abbreviations</head><item><term>BSA = bovine serum albumin</term></item><item><term>IGF = insulin-like growth factor</term></item><item><term>TCA = trichloroacetic acid</term></item><item><term>TMA = trimethylamine</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1993-09-09">Registration</change><change when="1993">Published</change></revisionDesc></teiHeader></istex:fulltextTEI></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla"><item-info><jid>FCT</jid><aid>94900752</aid><ce:pii>0278-6915(94)90075-2</ce:pii><ce:doi>10.1016/0278-6915(94)90075-2</ce:doi><ce:copyright type="unknown" year="1994"></ce:copyright></item-info><head><ce:title>Mechanism of trimethylamine-induced inhibition of macromolecular synthesis by mouse embryos in culture</ce:title><ce:author-group><ce:author><ce:given-name>I.</ce:given-name><ce:surname>Guest</ce:surname></ce:author><ce:author><ce:given-name>D.G.</ce:given-name><ce:surname>Cyr</ce:surname></ce:author><ce:author><ce:given-name>D.R.</ce:given-name><ce:surname>Varma</ce:surname><ce:cross-ref refid="COR1"><ce:sup>∗</ce:sup></ce:cross-ref></ce:author><ce:affiliation><ce:textfn>Department of Pharmacology and Therapeutics, McGill University, 3655 Drummond Street, Montreal, Canada H3G 1Y6</ce:textfn></ce:affiliation><ce:correspondence id="COR1"><ce:label>∗</ce:label><ce:text>To whom correspondence should be addressed.</ce:text></ce:correspondence></ce:author-group><ce:date-accepted day="9" month="9" year="1993"></ce:date-accepted><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>The effects of trimethylamine (TMA) on uptake mechanisms and lysosomal function were studied in mouse embryos, isolated yolk sacs and limb buds. TMA at 0.75 m<ce:small-caps>m</ce:small-caps> did not inhibit uptake of [<ce:sup loc="pre">14</ce:sup>C]sucrose by yolk sacs of day 9 embryos or by day 15 isolated yolk sacs but did inhibit uptake of <ce:sup>125</ce:sup>I-labelled bovine serum albumin ([<ce:sup loc="pre">125</ce:sup>I]BSA) by day 15 isolated yolk sacs. Concentrations of TMA up to 2.5 m<ce:small-caps>m</ce:small-caps> did not inhibit lysosomal degradation of [<ce:sup loc="pre">125</ce:sup>I]BSA by isolated yolk sacs, as judged by the release of trichloroacetic acid (TCA)-soluble radioactivity into the culture media. The inhibition of [<ce:sup loc="pre">125</ce:sup>I]BSA uptake induced by TMA was reversible on removal of TMA. When day 8 embryos were cultured in serum containing [<ce:sup loc="pre">3</ce:sup>H]leucine-labelled proteins, uptake and incorporation of radioactivity in 0.75 m<ce:small-caps>m</ce:small-caps> TMA-treated embryos was 47 and 44%, respectively, of that in untreated controls. TMA at 0.75 m<ce:small-caps>m</ce:small-caps> did not inhibit the uptake and incorporation of free [<ce:sup loc="pre">3</ce:sup>H]leucine into embryonic protein nor the amount of free [<ce:sup loc="pre">3</ce:sup>H]leucine taken up or incorporated into protein by day 12 isolated limb buds. It is concluded that the reduced macromolecular synthesis in embryos exposed to TMA is due to an inhibition of receptor-medicated uptake of nutrients by the yolk sac.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords class="abr"><ce:section-title>Abbreviations</ce:section-title><ce:keyword><ce:text>BSA = bovine serum albumin</ce:text></ce:keyword><ce:keyword><ce:text>IGF = insulin-like growth factor</ce:text></ce:keyword><ce:keyword><ce:text>TCA = trichloroacetic acid</ce:text></ce:keyword><ce:keyword><ce:text>TMA = trimethylamine</ce:text></ce:keyword></ce:keywords></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Mechanism of trimethylamine-induced inhibition of macromolecular synthesis by mouse embryos in culture</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Mechanism of trimethylamine-induced inhibition of macromolecular synthesis by mouse embryos in culture</title></titleInfo><name type="personal"><namePart type="given">I.</namePart><namePart type="family">Guest</namePart><affiliation>Department of Pharmacology and Therapeutics, McGill University, 3655 Drummond Street, Montreal, Canada H3G 1Y6</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D.G.</namePart><namePart type="family">Cyr</namePart><affiliation>Department of Pharmacology and Therapeutics, McGill University, 3655 Drummond Street, Montreal, Canada H3G 1Y6</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D.R.</namePart><namePart type="family">Varma</namePart><affiliation>Department of Pharmacology and Therapeutics, McGill University, 3655 Drummond Street, Montreal, Canada H3G 1Y6</affiliation><description>To whom correspondence should be addressed.</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article"></genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1993</dateIssued><dateValid encoding="w3cdtf">1993-09-09</dateValid><copyrightDate encoding="w3cdtf">1994</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">The effects of trimethylamine (TMA) on uptake mechanisms and lysosomal function were studied in mouse embryos, isolated yolk sacs and limb buds. TMA at 0.75 mm did not inhibit uptake of [14C]sucrose by yolk sacs of day 9 embryos or by day 15 isolated yolk sacs but did inhibit uptake of 125I-labelled bovine serum albumin ([125I]BSA) by day 15 isolated yolk sacs. Concentrations of TMA up to 2.5 mm did not inhibit lysosomal degradation of [125I]BSA by isolated yolk sacs, as judged by the release of trichloroacetic acid (TCA)-soluble radioactivity into the culture media. The inhibition of [125I]BSA uptake induced by TMA was reversible on removal of TMA. When day 8 embryos were cultured in serum containing [3H]leucine-labelled proteins, uptake and incorporation of radioactivity in 0.75 mm TMA-treated embryos was 47 and 44%, respectively, of that in untreated controls. TMA at 0.75 mm did not inhibit the uptake and incorporation of free [3H]leucine into embryonic protein nor the amount of free [3H]leucine taken up or incorporated into protein by day 12 isolated limb buds. It is concluded that the reduced macromolecular synthesis in embryos exposed to TMA is due to an inhibition of receptor-medicated uptake of nutrients by the yolk sac.</abstract><subject><genre>Abbreviations</genre><topic>BSA = bovine serum albumin</topic><topic>IGF = insulin-like growth factor</topic><topic>TCA = trichloroacetic acid</topic><topic>TMA = trimethylamine</topic></subject><relatedItem type="host"><titleInfo><title>Food and Chemical Toxicology</title></titleInfo><titleInfo type="abbreviated"><title>FCT</title></titleInfo><genre type="Journal">journal</genre><originInfo><dateIssued encoding="w3cdtf">199404</dateIssued></originInfo><identifier type="ISSN">0278-6915</identifier><identifier type="PII">S0278-6915(00)X0192-5</identifier><part><date>199404</date><detail type="volume"><number>32</number><caption>vol.</caption></detail><detail type="issue"><number>4</number><caption>no.</caption></detail><extent unit="issue pages"><start>297</start><end>395</end></extent><extent unit="pages"><start>365</start><end>371</end></extent></part></relatedItem><identifier type="istex">D6962CA9DF95F8F2CD58C6A82AF9E74AA56C7F36</identifier><identifier type="DOI">10.1016/0278-6915(94)90075-2</identifier><identifier type="PII">0278-6915(94)90075-2</identifier><recordInfo><recordContentSource>ELSEVIER</recordContentSource></recordInfo></mods></metadata><enrichments><istex:catWosTEI uri="https://api.istex.fr/document/D6962CA9DF95F8F2CD58C6A82AF9E74AA56C7F36/enrichments/catWos"><teiHeader><profileDesc><textClass><classCode scheme="WOS">TOXICOLOGY</classCode><classCode scheme="WOS">TRANSPLANTATION</classCode><classCode scheme="WOS">FOOD SCIENCE & TECHNOLOGY</classCode></textClass></profileDesc></teiHeader></istex:catWosTEI></enrichments></istex></record>Pour manipuler ce document sous Unix (Dilib)
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