Electrical characteristics in an excitable element of lipid membrane
Identifieur interne : 002630 ( Istex/Corpus ); précédent : 002629; suivant : 002631Electrical characteristics in an excitable element of lipid membrane
Auteurs : Kiyoshi Toko ; Norimasa Ozaki ; Satoru Iiyama ; Kaoru Yamafuji ; Yoshiko Matsui ; Keiko Yamafuji ; Minoru Saito ; Masakazu KatoSource :
- Biophysical Chemistry [ 0301-4622 ] ; 1991.
Abstract
Electrical characteristics in a membrane constructed from a porous filter adsorbed with a lipid analogue, dioleyl phosphate (DOPH), were investigated in a situation interposed between 100 mM NACl + 3 mM CaCl2 and 100 mM KCl. Calcium ions affected significantly the membrane characteristics. The membrane potential was negative on the KCl side, which implies the higher permeability to K+ than Na+; this tendency was increased by a tiny amount of Ca2+. While the membrane showed a low electrical resistance of several kΩ. cm2under K+/Na+ gradient, it showed several MΩ · cm2+ by Ca2+. The surface structure of the membrane exhibited many voids in the low-resistance state, but the surface was covered by oil droplets in the high-resistance state. Oscillations of the membrane potential appeared spontaneously with application of the electrical current from the KCl side to the NaCl + CaCl2 side. The frequency was increased with the electrical current. All these results were explained comprehensively using an electrochemical kinetic model taking account of the Ca2+ binding effect, where DOPH assemblies make a phase transition between oil droplets due to Ca2+ and multi-bilayers with excess K+. The oscillation arises from coupling of the phase transition to accumulation and release of K+ or Ca2+. This membrane can be used as an excitable element regulated by Ca2+ in neuro-computer devices.
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DOI: 10.1016/0301-4622(91)80014-I
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<front><div type="abstract" xml:lang="en">Electrical characteristics in a membrane constructed from a porous filter adsorbed with a lipid analogue, dioleyl phosphate (DOPH), were investigated in a situation interposed between 100 mM NACl + 3 mM CaCl2 and 100 mM KCl. Calcium ions affected significantly the membrane characteristics. The membrane potential was negative on the KCl side, which implies the higher permeability to K+ than Na+; this tendency was increased by a tiny amount of Ca2+. While the membrane showed a low electrical resistance of several kΩ. cm2under K+/Na+ gradient, it showed several MΩ · cm2+ by Ca2+. The surface structure of the membrane exhibited many voids in the low-resistance state, but the surface was covered by oil droplets in the high-resistance state. Oscillations of the membrane potential appeared spontaneously with application of the electrical current from the KCl side to the NaCl + CaCl2 side. The frequency was increased with the electrical current. All these results were explained comprehensively using an electrochemical kinetic model taking account of the Ca2+ binding effect, where DOPH assemblies make a phase transition between oil droplets due to Ca2+ and multi-bilayers with excess K+. The oscillation arises from coupling of the phase transition to accumulation and release of K+ or Ca2+. This membrane can be used as an excitable element regulated by Ca2+ in neuro-computer devices.</div>
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<abstract xml:lang="en"><p>Electrical characteristics in a membrane constructed from a porous filter adsorbed with a lipid analogue, dioleyl phosphate (DOPH), were investigated in a situation interposed between 100 mM NACl + 3 mM CaCl2 and 100 mM KCl. Calcium ions affected significantly the membrane characteristics. The membrane potential was negative on the KCl side, which implies the higher permeability to K+ than Na+; this tendency was increased by a tiny amount of Ca2+. While the membrane showed a low electrical resistance of several kΩ. cm2under K+/Na+ gradient, it showed several MΩ · cm2+ by Ca2+. The surface structure of the membrane exhibited many voids in the low-resistance state, but the surface was covered by oil droplets in the high-resistance state. Oscillations of the membrane potential appeared spontaneously with application of the electrical current from the KCl side to the NaCl + CaCl2 side. The frequency was increased with the electrical current. All these results were explained comprehensively using an electrochemical kinetic model taking account of the Ca2+ binding effect, where DOPH assemblies make a phase transition between oil droplets due to Ca2+ and multi-bilayers with excess K+. The oscillation arises from coupling of the phase transition to accumulation and release of K+ or Ca2+. This membrane can be used as an excitable element regulated by Ca2+ in neuro-computer devices.</p>
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<ce:date-accepted day="5" month="3" year="1991"></ce:date-accepted>
<ce:abstract><ce:section-title>Abstract</ce:section-title>
<ce:abstract-sec><ce:simple-para>Electrical characteristics in a membrane constructed from a porous filter adsorbed with a lipid analogue, dioleyl phosphate (DOPH), were investigated in a situation interposed between 100 m<ce:italic>M</ce:italic>
NACl + 3 m<ce:italic>M</ce:italic>
CaCl<ce:inf>2</ce:inf>
and 100 m<ce:italic>M</ce:italic>
KCl. Calcium ions affected significantly the membrane characteristics. The membrane potential was negative on the KCl side, which implies the higher permeability to K<ce:sup>+</ce:sup>
than Na<ce:sup>+</ce:sup>
; this tendency was increased by a tiny amount of Ca<ce:sup>2+</ce:sup>
. While the membrane showed a low electrical resistance of several kΩ. cm<ce:sup>2</ce:sup>
under K<ce:sup>+</ce:sup>
/Na<ce:sup>+</ce:sup>
gradient, it showed several MΩ · cm<ce:sup>2+</ce:sup>
by Ca<ce:sup>2+</ce:sup>
. The surface structure of the membrane exhibited many voids in the low-resistance state, but the surface was covered by oil droplets in the high-resistance state. Oscillations of the membrane potential appeared spontaneously with application of the electrical current from the KCl side to the NaCl + CaCl<ce:inf>2</ce:inf>
side. The frequency was increased with the electrical current. All these results were explained comprehensively using an electrochemical kinetic model taking account of the Ca<ce:sup>2+</ce:sup>
binding effect, where DOPH assemblies make a phase transition between oil droplets due to Ca<ce:sup>2+</ce:sup>
and multi-bilayers with excess K<ce:sup>+</ce:sup>
. The oscillation arises from coupling of the phase transition to accumulation and release of K<ce:sup>+</ce:sup>
or Ca<ce:sup>2+</ce:sup>
. This membrane can be used as an excitable element regulated by Ca<ce:sup>2+</ce:sup>
in neuro-computer devices.</ce:simple-para>
</ce:abstract-sec>
</ce:abstract>
<ce:keywords><ce:section-title>Keywords</ce:section-title>
<ce:keyword><ce:text>Lipid membrane</ce:text>
</ce:keyword>
<ce:keyword><ce:text>Phase transition</ce:text>
</ce:keyword>
<ce:keyword><ce:text>Oscillation</ce:text>
</ce:keyword>
<ce:keyword><ce:text>Excitability</ce:text>
</ce:keyword>
<ce:keyword><ce:text>Ca <ce:sup loc="pre">2+</ce:sup>
binding</ce:text>
</ce:keyword>
<ce:keyword><ce:text>Neuro-computer</ce:text>
</ce:keyword>
</ce:keywords>
</head>
</converted-article>
</istex:document>
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<mods version="3.6"><titleInfo><title>Electrical characteristics in an excitable element of lipid membrane</title>
</titleInfo>
<titleInfo type="alternative" contentType="CDATA"><title>Electrical characteristics in an excitable element of lipid membrane</title>
</titleInfo>
<name type="personal"><namePart type="given">Kiyoshi</namePart>
<namePart type="family">Toko</namePart>
<affiliation>Department of Electronics, Faculty of Engineering, Kyushu University 36, Fukuoka 812 Japan</affiliation>
<description>To whom correspondence should be addressed.</description>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Norimasa</namePart>
<namePart type="family">Ozaki</namePart>
<affiliation>Department of Electronics, Faculty of Engineering, Kyushu University 36, Fukuoka 812 Japan</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Satoru</namePart>
<namePart type="family">Iiyama</namePart>
<affiliation>Department of Home Economics, Kyushu Junior College of Kinki University, Iizuka 820 Japan</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Kaoru</namePart>
<namePart type="family">Yamafuji</namePart>
<affiliation>Department of Electronics, Faculty of Engineering, Kyushu University 36, Fukuoka 812 Japan</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Yoshiko</namePart>
<namePart type="family">Matsui</namePart>
<affiliation>Department of Food and Nutrition, Nakamura Gakuen College, Fukuoka 814 Japan</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Keiko</namePart>
<namePart type="family">Yamafuji</namePart>
<affiliation>Department of Food and Nutrition, Nakamura Gakuen College, Fukuoka 814 Japan</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Minoru</namePart>
<namePart type="family">Saito</namePart>
<affiliation>Oki Electric Industty Co., Ltd., Hachioji, Tokyo 193 Japan</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Masakazu</namePart>
<namePart type="family">Kato</namePart>
<affiliation>Oki Electric Industty Co., Ltd., Hachioji, Tokyo 193 Japan</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<typeOfResource>text</typeOfResource>
<genre type="research-article" displayLabel="Full-length article"></genre>
<originInfo><publisher>ELSEVIER</publisher>
<dateIssued encoding="w3cdtf">1991</dateIssued>
<dateValid encoding="w3cdtf">1991-03-05</dateValid>
<copyrightDate encoding="w3cdtf">1991</copyrightDate>
</originInfo>
<language><languageTerm type="code" authority="iso639-2b">eng</languageTerm>
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<abstract lang="en">Electrical characteristics in a membrane constructed from a porous filter adsorbed with a lipid analogue, dioleyl phosphate (DOPH), were investigated in a situation interposed between 100 mM NACl + 3 mM CaCl2 and 100 mM KCl. Calcium ions affected significantly the membrane characteristics. The membrane potential was negative on the KCl side, which implies the higher permeability to K+ than Na+; this tendency was increased by a tiny amount of Ca2+. While the membrane showed a low electrical resistance of several kΩ. cm2under K+/Na+ gradient, it showed several MΩ · cm2+ by Ca2+. The surface structure of the membrane exhibited many voids in the low-resistance state, but the surface was covered by oil droplets in the high-resistance state. Oscillations of the membrane potential appeared spontaneously with application of the electrical current from the KCl side to the NaCl + CaCl2 side. The frequency was increased with the electrical current. All these results were explained comprehensively using an electrochemical kinetic model taking account of the Ca2+ binding effect, where DOPH assemblies make a phase transition between oil droplets due to Ca2+ and multi-bilayers with excess K+. The oscillation arises from coupling of the phase transition to accumulation and release of K+ or Ca2+. This membrane can be used as an excitable element regulated by Ca2+ in neuro-computer devices.</abstract>
<subject><genre>Keywords</genre>
<topic>Lipid membrane</topic>
<topic>Phase transition</topic>
<topic>Oscillation</topic>
<topic>Excitability</topic>
<topic>Ca 2+ binding</topic>
<topic>Neuro-computer</topic>
</subject>
<relatedItem type="host"><titleInfo><title>Biophysical Chemistry</title>
</titleInfo>
<titleInfo type="abbreviated"><title>BIOCHE</title>
</titleInfo>
<genre type="Journal">journal</genre>
<originInfo><dateIssued encoding="w3cdtf">199111</dateIssued>
</originInfo>
<identifier type="ISSN">0301-4622</identifier>
<identifier type="PII">S0301-4622(00)X0211-6</identifier>
<part><date>199111</date>
<detail type="volume"><number>41</number>
<caption>vol.</caption>
</detail>
<detail type="issue"><number>2</number>
<caption>no.</caption>
</detail>
<extent unit="issue pages"><start>111</start>
<end>216</end>
</extent>
<extent unit="pages"><start>143</start>
<end>156</end>
</extent>
</part>
</relatedItem>
<identifier type="istex">F55E1923E967EE7771B544BFEAEE67D43293E1AA</identifier>
<identifier type="DOI">10.1016/0301-4622(91)80014-I</identifier>
<identifier type="PII">0301-4622(91)80014-I</identifier>
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