Electrical characteristics in an excitable element of lipid membrane
Identifieur interne : 002630 ( Istex/Corpus ); précédent : 002629; suivant : 002631Electrical characteristics in an excitable element of lipid membrane
Auteurs : Kiyoshi Toko ; Norimasa Ozaki ; Satoru Iiyama ; Kaoru Yamafuji ; Yoshiko Matsui ; Keiko Yamafuji ; Minoru Saito ; Masakazu KatoSource :
- Biophysical Chemistry [ 0301-4622 ] ; 1991.
Abstract
Electrical characteristics in a membrane constructed from a porous filter adsorbed with a lipid analogue, dioleyl phosphate (DOPH), were investigated in a situation interposed between 100 mM NACl + 3 mM CaCl2 and 100 mM KCl. Calcium ions affected significantly the membrane characteristics. The membrane potential was negative on the KCl side, which implies the higher permeability to K+ than Na+; this tendency was increased by a tiny amount of Ca2+. While the membrane showed a low electrical resistance of several kΩ. cm2under K+/Na+ gradient, it showed several MΩ · cm2+ by Ca2+. The surface structure of the membrane exhibited many voids in the low-resistance state, but the surface was covered by oil droplets in the high-resistance state. Oscillations of the membrane potential appeared spontaneously with application of the electrical current from the KCl side to the NaCl + CaCl2 side. The frequency was increased with the electrical current. All these results were explained comprehensively using an electrochemical kinetic model taking account of the Ca2+ binding effect, where DOPH assemblies make a phase transition between oil droplets due to Ca2+ and multi-bilayers with excess K+. The oscillation arises from coupling of the phase transition to accumulation and release of K+ or Ca2+. This membrane can be used as an excitable element regulated by Ca2+ in neuro-computer devices.
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DOI: 10.1016/0301-4622(91)80014-I
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Electrical characteristics in an excitable element of lipid membrane</title><author><name sortKey="Toko, Kiyoshi" sort="Toko, Kiyoshi" uniqKey="Toko K" first="Kiyoshi" last="Toko">Kiyoshi Toko</name><affiliation><mods:affiliation>Department of Electronics, Faculty of Engineering, Kyushu University 36, Fukuoka 812 Japan</mods:affiliation></affiliation></author><author><name sortKey="Ozaki, Norimasa" sort="Ozaki, Norimasa" uniqKey="Ozaki N" first="Norimasa" last="Ozaki">Norimasa Ozaki</name><affiliation><mods:affiliation>Department of Electronics, Faculty of Engineering, Kyushu University 36, Fukuoka 812 Japan</mods:affiliation></affiliation></author><author><name sortKey="Iiyama, Satoru" sort="Iiyama, Satoru" uniqKey="Iiyama S" first="Satoru" last="Iiyama">Satoru Iiyama</name><affiliation><mods:affiliation>Department of Home Economics, Kyushu Junior College of Kinki University, Iizuka 820 Japan</mods:affiliation></affiliation></author><author><name sortKey="Yamafuji, Kaoru" sort="Yamafuji, Kaoru" uniqKey="Yamafuji K" first="Kaoru" last="Yamafuji">Kaoru Yamafuji</name><affiliation><mods:affiliation>Department of Electronics, Faculty of Engineering, Kyushu University 36, Fukuoka 812 Japan</mods:affiliation></affiliation></author><author><name sortKey="Matsui, Yoshiko" sort="Matsui, Yoshiko" uniqKey="Matsui Y" first="Yoshiko" last="Matsui">Yoshiko Matsui</name><affiliation><mods:affiliation>Department of Food and Nutrition, Nakamura Gakuen College, Fukuoka 814 Japan</mods:affiliation></affiliation></author><author><name sortKey="Yamafuji, Keiko" sort="Yamafuji, Keiko" uniqKey="Yamafuji K" first="Keiko" last="Yamafuji">Keiko Yamafuji</name><affiliation><mods:affiliation>Department of Food and Nutrition, Nakamura Gakuen College, Fukuoka 814 Japan</mods:affiliation></affiliation></author><author><name sortKey="Saito, Minoru" sort="Saito, Minoru" uniqKey="Saito M" first="Minoru" last="Saito">Minoru Saito</name><affiliation><mods:affiliation>Oki Electric Industty Co., Ltd., Hachioji, Tokyo 193 Japan</mods:affiliation></affiliation></author><author><name sortKey="Kato, Masakazu" sort="Kato, Masakazu" uniqKey="Kato M" first="Masakazu" last="Kato">Masakazu Kato</name><affiliation><mods:affiliation>Oki Electric Industty Co., Ltd., Hachioji, Tokyo 193 Japan</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:F55E1923E967EE7771B544BFEAEE67D43293E1AA</idno><date when="1991" year="1991">1991</date><idno type="doi">10.1016/0301-4622(91)80014-I</idno><idno type="url">https://api.istex.fr/document/F55E1923E967EE7771B544BFEAEE67D43293E1AA/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">002630</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Electrical characteristics in an excitable element of lipid membrane</title><author><name sortKey="Toko, Kiyoshi" sort="Toko, Kiyoshi" uniqKey="Toko K" first="Kiyoshi" last="Toko">Kiyoshi Toko</name><affiliation><mods:affiliation>Department of Electronics, Faculty of Engineering, Kyushu University 36, Fukuoka 812 Japan</mods:affiliation></affiliation></author><author><name sortKey="Ozaki, Norimasa" sort="Ozaki, Norimasa" uniqKey="Ozaki N" first="Norimasa" last="Ozaki">Norimasa Ozaki</name><affiliation><mods:affiliation>Department of Electronics, Faculty of Engineering, Kyushu University 36, Fukuoka 812 Japan</mods:affiliation></affiliation></author><author><name sortKey="Iiyama, Satoru" sort="Iiyama, Satoru" uniqKey="Iiyama S" first="Satoru" last="Iiyama">Satoru Iiyama</name><affiliation><mods:affiliation>Department of Home Economics, Kyushu Junior College of Kinki University, Iizuka 820 Japan</mods:affiliation></affiliation></author><author><name sortKey="Yamafuji, Kaoru" sort="Yamafuji, Kaoru" uniqKey="Yamafuji K" first="Kaoru" last="Yamafuji">Kaoru Yamafuji</name><affiliation><mods:affiliation>Department of Electronics, Faculty of Engineering, Kyushu University 36, Fukuoka 812 Japan</mods:affiliation></affiliation></author><author><name sortKey="Matsui, Yoshiko" sort="Matsui, Yoshiko" uniqKey="Matsui Y" first="Yoshiko" last="Matsui">Yoshiko Matsui</name><affiliation><mods:affiliation>Department of Food and Nutrition, Nakamura Gakuen College, Fukuoka 814 Japan</mods:affiliation></affiliation></author><author><name sortKey="Yamafuji, Keiko" sort="Yamafuji, Keiko" uniqKey="Yamafuji K" first="Keiko" last="Yamafuji">Keiko Yamafuji</name><affiliation><mods:affiliation>Department of Food and Nutrition, Nakamura Gakuen College, Fukuoka 814 Japan</mods:affiliation></affiliation></author><author><name sortKey="Saito, Minoru" sort="Saito, Minoru" uniqKey="Saito M" first="Minoru" last="Saito">Minoru Saito</name><affiliation><mods:affiliation>Oki Electric Industty Co., Ltd., Hachioji, Tokyo 193 Japan</mods:affiliation></affiliation></author><author><name sortKey="Kato, Masakazu" sort="Kato, Masakazu" uniqKey="Kato M" first="Masakazu" last="Kato">Masakazu Kato</name><affiliation><mods:affiliation>Oki Electric Industty Co., Ltd., Hachioji, Tokyo 193 Japan</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Biophysical Chemistry</title><title level="j" type="abbrev">BIOCHE</title><idno type="ISSN">0301-4622</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1991">1991</date><biblScope unit="volume">41</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="143">143</biblScope><biblScope unit="page" to="156">156</biblScope></imprint><idno type="ISSN">0301-4622</idno></series><idno type="istex">F55E1923E967EE7771B544BFEAEE67D43293E1AA</idno><idno type="DOI">10.1016/0301-4622(91)80014-I</idno><idno type="PII">0301-4622(91)80014-I</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0301-4622</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Electrical characteristics in a membrane constructed from a porous filter adsorbed with a lipid analogue, dioleyl phosphate (DOPH), were investigated in a situation interposed between 100 mM NACl + 3 mM CaCl2 and 100 mM KCl. Calcium ions affected significantly the membrane characteristics. The membrane potential was negative on the KCl side, which implies the higher permeability to K+ than Na+; this tendency was increased by a tiny amount of Ca2+. While the membrane showed a low electrical resistance of several kΩ. cm2under K+/Na+ gradient, it showed several MΩ · cm2+ by Ca2+. The surface structure of the membrane exhibited many voids in the low-resistance state, but the surface was covered by oil droplets in the high-resistance state. Oscillations of the membrane potential appeared spontaneously with application of the electrical current from the KCl side to the NaCl + CaCl2 side. The frequency was increased with the electrical current. All these results were explained comprehensively using an electrochemical kinetic model taking account of the Ca2+ binding effect, where DOPH assemblies make a phase transition between oil droplets due to Ca2+ and multi-bilayers with excess K+. The oscillation arises from coupling of the phase transition to accumulation and release of K+ or Ca2+. This membrane can be used as an excitable element regulated by Ca2+ in neuro-computer devices.</div></front></TEI><istex><corpusName>elsevier</corpusName><author><json:item><name>Kiyoshi Toko</name><affiliations><json:string>Department of Electronics, Faculty of Engineering, Kyushu University 36, Fukuoka 812 Japan</json:string></affiliations></json:item><json:item><name>Norimasa Ozaki</name><affiliations><json:string>Department of Electronics, Faculty of Engineering, Kyushu University 36, Fukuoka 812 Japan</json:string></affiliations></json:item><json:item><name>Satoru Iiyama</name><affiliations><json:string>Department of Home Economics, Kyushu Junior College of Kinki University, Iizuka 820 Japan</json:string></affiliations></json:item><json:item><name>Kaoru Yamafuji</name><affiliations><json:string>Department of Electronics, Faculty of Engineering, Kyushu University 36, Fukuoka 812 Japan</json:string></affiliations></json:item><json:item><name>Yoshiko Matsui</name><affiliations><json:string>Department of Food and Nutrition, Nakamura Gakuen College, Fukuoka 814 Japan</json:string></affiliations></json:item><json:item><name>Keiko Yamafuji</name><affiliations><json:string>Department of Food and Nutrition, Nakamura Gakuen College, Fukuoka 814 Japan</json:string></affiliations></json:item><json:item><name>Minoru Saito</name><affiliations><json:string>Oki Electric Industty Co., Ltd., Hachioji, Tokyo 193 Japan</json:string></affiliations></json:item><json:item><name>Masakazu Kato</name><affiliations><json:string>Oki Electric Industty Co., Ltd., Hachioji, Tokyo 193 Japan</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Lipid membrane</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Phase transition</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Oscillation</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Excitability</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Ca 2+ binding</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Neuro-computer</value></json:item></subject><language><json:string>eng</json:string></language><abstract>Electrical characteristics in a membrane constructed from a porous filter adsorbed with a lipid analogue, dioleyl phosphate (DOPH), were investigated in a situation interposed between 100 mM NACl + 3 mM CaCl2 and 100 mM KCl. Calcium ions affected significantly the membrane characteristics. The membrane potential was negative on the KCl side, which implies the higher permeability to K+ than Na+; this tendency was increased by a tiny amount of Ca2+. While the membrane showed a low electrical resistance of several kΩ. cm2under K+/Na+ gradient, it showed several MΩ · cm2+ by Ca2+. The surface structure of the membrane exhibited many voids in the low-resistance state, but the surface was covered by oil droplets in the high-resistance state. Oscillations of the membrane potential appeared spontaneously with application of the electrical current from the KCl side to the NaCl + CaCl2 side. The frequency was increased with the electrical current. All these results were explained comprehensively using an electrochemical kinetic model taking account of the Ca2+ binding effect, where DOPH assemblies make a phase transition between oil droplets due to Ca2+ and multi-bilayers with excess K+. The oscillation arises from coupling of the phase transition to accumulation and release of K+ or Ca2+. This membrane can be used as an excitable element regulated by Ca2+ in neuro-computer devices.</abstract><qualityIndicators><score>8.104</score><pdfVersion>1.4</pdfVersion><pdfPageSize>510 x 700 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>6</keywordCount><abstractCharCount>1395</abstractCharCount><pdfWordCount>6382</pdfWordCount><pdfCharCount>36571</pdfCharCount><pdfPageCount>14</pdfPageCount><abstractWordCount>217</abstractWordCount></qualityIndicators><title>Electrical characteristics in an excitable element of lipid membrane</title><pii><json:string>0301-4622(91)80014-I</json:string></pii><genre><json:string>research-article</json:string></genre><host><volume>41</volume><pii><json:string>S0301-4622(00)X0211-6</json:string></pii><pages><last>156</last><first>143</first></pages><issn><json:string>0301-4622</json:string></issn><issue>2</issue><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><title>Biophysical 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812 Japan</affiliation></author><author><persName><forename type="first">Satoru</forename><surname>Iiyama</surname></persName><affiliation>Department of Home Economics, Kyushu Junior College of Kinki University, Iizuka 820 Japan</affiliation></author><author><persName><forename type="first">Kaoru</forename><surname>Yamafuji</surname></persName><affiliation>Department of Electronics, Faculty of Engineering, Kyushu University 36, Fukuoka 812 Japan</affiliation></author><author><persName><forename type="first">Yoshiko</forename><surname>Matsui</surname></persName><affiliation>Department of Food and Nutrition, Nakamura Gakuen College, Fukuoka 814 Japan</affiliation></author><author><persName><forename type="first">Keiko</forename><surname>Yamafuji</surname></persName><affiliation>Department of Food and Nutrition, Nakamura Gakuen College, Fukuoka 814 Japan</affiliation></author><author><persName><forename type="first">Minoru</forename><surname>Saito</surname></persName><affiliation>Oki Electric Industty Co., Ltd., Hachioji, Tokyo 193 Japan</affiliation></author><author><persName><forename type="first">Masakazu</forename><surname>Kato</surname></persName><affiliation>Oki Electric Industty Co., Ltd., Hachioji, Tokyo 193 Japan</affiliation></author></analytic><monogr><title level="j">Biophysical Chemistry</title><title level="j" type="abbrev">BIOCHE</title><idno type="pISSN">0301-4622</idno><idno type="PII">S0301-4622(00)X0211-6</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1991"></date><biblScope unit="volume">41</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="143">143</biblScope><biblScope unit="page" to="156">156</biblScope></imprint></monogr><idno type="istex">F55E1923E967EE7771B544BFEAEE67D43293E1AA</idno><idno type="DOI">10.1016/0301-4622(91)80014-I</idno><idno type="PII">0301-4622(91)80014-I</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1991</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Electrical characteristics in a membrane constructed from a porous filter adsorbed with a lipid analogue, dioleyl phosphate (DOPH), were investigated in a situation interposed between 100 mM NACl + 3 mM CaCl2 and 100 mM KCl. Calcium ions affected significantly the membrane characteristics. The membrane potential was negative on the KCl side, which implies the higher permeability to K+ than Na+; this tendency was increased by a tiny amount of Ca2+. While the membrane showed a low electrical resistance of several kΩ. cm2under K+/Na+ gradient, it showed several MΩ · cm2+ by Ca2+. The surface structure of the membrane exhibited many voids in the low-resistance state, but the surface was covered by oil droplets in the high-resistance state. Oscillations of the membrane potential appeared spontaneously with application of the electrical current from the KCl side to the NaCl + CaCl2 side. The frequency was increased with the electrical current. All these results were explained comprehensively using an electrochemical kinetic model taking account of the Ca2+ binding effect, where DOPH assemblies make a phase transition between oil droplets due to Ca2+ and multi-bilayers with excess K+. The oscillation arises from coupling of the phase transition to accumulation and release of K+ or Ca2+. This membrane can be used as an excitable element regulated by Ca2+ in neuro-computer devices.</p></abstract><textClass><keywords scheme="keyword"><list><head>Keywords</head><item><term>Lipid membrane</term></item><item><term>Phase transition</term></item><item><term>Oscillation</term></item><item><term>Excitability</term></item><item><term>Ca 2+ binding</term></item><item><term>Neuro-computer</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1991-03-05">Registration</change><change when="1991">Published</change></revisionDesc></teiHeader></istex:fulltextTEI></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla"><item-info><jid>BIOCHE</jid><aid>9180014I</aid><ce:pii>0301-4622(91)80014-I</ce:pii><ce:doi>10.1016/0301-4622(91)80014-I</ce:doi><ce:copyright type="unknown" year="1991"></ce:copyright></item-info><head><ce:title>Electrical characteristics in an excitable element of lipid membrane</ce:title><ce:author-group><ce:author><ce:given-name>Kiyoshi</ce:given-name><ce:surname>Toko</ce:surname><ce:cross-ref refid="COR1"><ce:sup>∗</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Norimasa</ce:given-name><ce:surname>Ozaki</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Satoru</ce:given-name><ce:surname>Iiyama</ce:surname><ce:cross-ref refid="AFF2"><ce:sup>b</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Kaoru</ce:given-name><ce:surname>Yamafuji</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Yoshiko</ce:given-name><ce:surname>Matsui</ce:surname><ce:cross-ref refid="AFF3"><ce:sup>c</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Keiko</ce:given-name><ce:surname>Yamafuji</ce:surname><ce:cross-ref refid="AFF3"><ce:sup>c</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Minoru</ce:given-name><ce:surname>Saito</ce:surname><ce:cross-ref refid="AFF4"><ce:sup>d</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Masakazu</ce:given-name><ce:surname>Kato</ce:surname><ce:cross-ref refid="AFF4"><ce:sup>d</ce:sup></ce:cross-ref></ce:author><ce:affiliation id="AFF1"><ce:label>a</ce:label><ce:textfn>Department of Electronics, Faculty of Engineering, Kyushu University 36, Fukuoka 812 Japan</ce:textfn></ce:affiliation><ce:affiliation id="AFF2"><ce:label>b</ce:label><ce:textfn>Department of Home Economics, Kyushu Junior College of Kinki University, Iizuka 820 Japan</ce:textfn></ce:affiliation><ce:affiliation id="AFF3"><ce:label>c</ce:label><ce:textfn>Department of Food and Nutrition, Nakamura Gakuen College, Fukuoka 814 Japan</ce:textfn></ce:affiliation><ce:affiliation id="AFF4"><ce:label>d</ce:label><ce:textfn>Oki Electric Industty Co., Ltd., Hachioji, Tokyo 193 Japan</ce:textfn></ce:affiliation><ce:correspondence id="COR1"><ce:label>*</ce:label><ce:text>To whom correspondence should be addressed.</ce:text></ce:correspondence></ce:author-group><ce:date-received day="24" month="5" year="1990"></ce:date-received><ce:date-accepted day="5" month="3" year="1991"></ce:date-accepted><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>Electrical characteristics in a membrane constructed from a porous filter adsorbed with a lipid analogue, dioleyl phosphate (DOPH), were investigated in a situation interposed between 100 m<ce:italic>M</ce:italic> NACl + 3 m<ce:italic>M</ce:italic> CaCl<ce:inf>2</ce:inf> and 100 m<ce:italic>M</ce:italic> KCl. Calcium ions affected significantly the membrane characteristics. The membrane potential was negative on the KCl side, which implies the higher permeability to K<ce:sup>+</ce:sup> than Na<ce:sup>+</ce:sup>; this tendency was increased by a tiny amount of Ca<ce:sup>2+</ce:sup>. While the membrane showed a low electrical resistance of several kΩ. cm<ce:sup>2</ce:sup>under K<ce:sup>+</ce:sup>/Na<ce:sup>+</ce:sup> gradient, it showed several MΩ · cm<ce:sup>2+</ce:sup> by Ca<ce:sup>2+</ce:sup>. The surface structure of the membrane exhibited many voids in the low-resistance state, but the surface was covered by oil droplets in the high-resistance state. Oscillations of the membrane potential appeared spontaneously with application of the electrical current from the KCl side to the NaCl + CaCl<ce:inf>2</ce:inf> side. The frequency was increased with the electrical current. All these results were explained comprehensively using an electrochemical kinetic model taking account of the Ca<ce:sup>2+</ce:sup> binding effect, where DOPH assemblies make a phase transition between oil droplets due to Ca<ce:sup>2+</ce:sup> and multi-bilayers with excess K<ce:sup>+</ce:sup>. The oscillation arises from coupling of the phase transition to accumulation and release of K<ce:sup>+</ce:sup> or Ca<ce:sup>2+</ce:sup>. This membrane can be used as an excitable element regulated by Ca<ce:sup>2+</ce:sup> in neuro-computer devices.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords><ce:section-title>Keywords</ce:section-title><ce:keyword><ce:text>Lipid membrane</ce:text></ce:keyword><ce:keyword><ce:text>Phase transition</ce:text></ce:keyword><ce:keyword><ce:text>Oscillation</ce:text></ce:keyword><ce:keyword><ce:text>Excitability</ce:text></ce:keyword><ce:keyword><ce:text>Ca <ce:sup loc="pre">2+</ce:sup> binding</ce:text></ce:keyword><ce:keyword><ce:text>Neuro-computer</ce:text></ce:keyword></ce:keywords></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Electrical characteristics in an excitable element of lipid membrane</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Electrical characteristics in an excitable element of lipid membrane</title></titleInfo><name type="personal"><namePart type="given">Kiyoshi</namePart><namePart type="family">Toko</namePart><affiliation>Department of Electronics, Faculty of Engineering, Kyushu University 36, Fukuoka 812 Japan</affiliation><description>To whom correspondence should be addressed.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Norimasa</namePart><namePart type="family">Ozaki</namePart><affiliation>Department of Electronics, Faculty of Engineering, Kyushu University 36, Fukuoka 812 Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Satoru</namePart><namePart type="family">Iiyama</namePart><affiliation>Department of Home Economics, Kyushu Junior College of Kinki University, Iizuka 820 Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Kaoru</namePart><namePart type="family">Yamafuji</namePart><affiliation>Department of Electronics, Faculty of Engineering, Kyushu University 36, Fukuoka 812 Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Yoshiko</namePart><namePart type="family">Matsui</namePart><affiliation>Department of Food and Nutrition, Nakamura Gakuen College, Fukuoka 814 Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Keiko</namePart><namePart type="family">Yamafuji</namePart><affiliation>Department of Food and Nutrition, Nakamura Gakuen College, Fukuoka 814 Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Minoru</namePart><namePart type="family">Saito</namePart><affiliation>Oki Electric Industty Co., Ltd., Hachioji, Tokyo 193 Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Masakazu</namePart><namePart type="family">Kato</namePart><affiliation>Oki Electric Industty Co., Ltd., Hachioji, Tokyo 193 Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article"></genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1991</dateIssued><dateValid encoding="w3cdtf">1991-03-05</dateValid><copyrightDate encoding="w3cdtf">1991</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">Electrical characteristics in a membrane constructed from a porous filter adsorbed with a lipid analogue, dioleyl phosphate (DOPH), were investigated in a situation interposed between 100 mM NACl + 3 mM CaCl2 and 100 mM KCl. Calcium ions affected significantly the membrane characteristics. The membrane potential was negative on the KCl side, which implies the higher permeability to K+ than Na+; this tendency was increased by a tiny amount of Ca2+. While the membrane showed a low electrical resistance of several kΩ. cm2under K+/Na+ gradient, it showed several MΩ · cm2+ by Ca2+. The surface structure of the membrane exhibited many voids in the low-resistance state, but the surface was covered by oil droplets in the high-resistance state. Oscillations of the membrane potential appeared spontaneously with application of the electrical current from the KCl side to the NaCl + CaCl2 side. The frequency was increased with the electrical current. All these results were explained comprehensively using an electrochemical kinetic model taking account of the Ca2+ binding effect, where DOPH assemblies make a phase transition between oil droplets due to Ca2+ and multi-bilayers with excess K+. The oscillation arises from coupling of the phase transition to accumulation and release of K+ or Ca2+. This membrane can be used as an excitable element regulated by Ca2+ in neuro-computer devices.</abstract><subject><genre>Keywords</genre><topic>Lipid membrane</topic><topic>Phase transition</topic><topic>Oscillation</topic><topic>Excitability</topic><topic>Ca 2+ binding</topic><topic>Neuro-computer</topic></subject><relatedItem type="host"><titleInfo><title>Biophysical Chemistry</title></titleInfo><titleInfo type="abbreviated"><title>BIOCHE</title></titleInfo><genre type="Journal">journal</genre><originInfo><dateIssued encoding="w3cdtf">199111</dateIssued></originInfo><identifier type="ISSN">0301-4622</identifier><identifier type="PII">S0301-4622(00)X0211-6</identifier><part><date>199111</date><detail type="volume"><number>41</number><caption>vol.</caption></detail><detail type="issue"><number>2</number><caption>no.</caption></detail><extent unit="issue pages"><start>111</start><end>216</end></extent><extent unit="pages"><start>143</start><end>156</end></extent></part></relatedItem><identifier type="istex">F55E1923E967EE7771B544BFEAEE67D43293E1AA</identifier><identifier type="DOI">10.1016/0301-4622(91)80014-I</identifier><identifier type="PII">0301-4622(91)80014-I</identifier><recordInfo><recordContentSource>ELSEVIER</recordContentSource></recordInfo></mods></metadata><enrichments><istex:catWosTEI uri="https://api.istex.fr/document/F55E1923E967EE7771B544BFEAEE67D43293E1AA/enrichments/catWos"><teiHeader><profileDesc><textClass><classCode scheme="WOS">CHEMISTRY, PHYSICAL</classCode><classCode scheme="WOS">BIOCHEMISTRY & MOLECULAR BIOLOGY</classCode><classCode scheme="WOS">BIOPHYSICS</classCode></textClass></profileDesc></teiHeader></istex:catWosTEI></enrichments><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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