Quantitative upper airway endoscopy with swept-source anatomical optical coherence tomography
Identifieur interne : 001303 ( Pmc/Curation ); précédent : 001302; suivant : 001304Quantitative upper airway endoscopy with swept-source anatomical optical coherence tomography
Auteurs : Kushal Wijesundara [États-Unis] ; Carlton Zdanski [États-Unis] ; Julia Kimbell [États-Unis] ; Hillel Price [États-Unis] ; Nicusor Iftimia [États-Unis] ; Amy L. Oldenburg [États-Unis]Source :
- Biomedical Optics Express [ 2156-7085 ] ; 2014.
Abstract
Minimally invasive imaging of upper airway obstructions in children and adults is needed to improve clinical decision-making. Toward this goal, we demonstrate an anatomical optical coherence tomography (aOCT) system delivered via a small-bore, flexible endoscope to quantify the upper airway lumen geometry. Helical scans were obtained from a proximally-scanned fiber-optic catheter of 820 μm outer diameter and >2 mm focal length. Coupled with a long coherence length wavelength-swept light source, the system exhibited an SNR roll-off of < 10 dB over a 10 mm range. Operating at 10 rotations/s, the average accuracy of segmented cross-sectional areas was found to be −1.4 ± 1.0%. To demonstrate the capability of this system, aOCT was performed on a pediatric airway phantom and on
Url:
DOI: 10.1364/BOE.5.000788
PubMed: 24688814
PubMed Central: 3959831
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<series><title level="j">Biomedical Optics Express</title>
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<front><div type="abstract" xml:lang="en"><p>Minimally invasive imaging of upper airway obstructions in children and adults is needed to improve clinical decision-making. Toward this goal, we demonstrate an anatomical optical coherence tomography (aOCT) system delivered via a small-bore, flexible endoscope to quantify the upper airway lumen geometry. Helical scans were obtained from a proximally-scanned fiber-optic catheter of 820 μm outer diameter and >2 mm focal length. Coupled with a long coherence length wavelength-swept light source, the system exhibited an SNR roll-off of < 10 dB over a 10 mm range. Operating at 10 rotations/s, the average accuracy of segmented cross-sectional areas was found to be −1.4 ± 1.0%. To demonstrate the capability of this system, aOCT was performed on a pediatric airway phantom and on <italic>ex vivo</italic>
swine trachea. The ability for quantitative endoscopy afforded by this system can aid in diagnosis, medical and surgical decision making, and predictive modeling of upper airway obstructive disorders.</p>
</div>
</front>
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<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Biomed Opt Express</journal-id>
<journal-id journal-id-type="iso-abbrev">Biomed Opt Express</journal-id>
<journal-id journal-id-type="publisher-id">BOE</journal-id>
<journal-title-group><journal-title>Biomedical Optics Express</journal-title>
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<issn pub-type="epub">2156-7085</issn>
<publisher><publisher-name>Optical Society of America</publisher-name>
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<article-id pub-id-type="doi">10.1364/BOE.5.000788</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Endoscopes, Catheters and Micro-Optics</subject>
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<subj-group subj-group-type="article-type"><subject>Research-Article</subject>
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<title-group><article-title>Quantitative upper airway endoscopy with swept-source anatomical optical coherence tomography</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Wijesundara</surname>
<given-names>Kushal</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Zdanski</surname>
<given-names>Carlton</given-names>
</name>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kimbell</surname>
<given-names>Julia</given-names>
</name>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Price</surname>
<given-names>Hillel</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Iftimia</surname>
<given-names>Nicusor</given-names>
</name>
<xref ref-type="aff" rid="aff3"><sup>3</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Oldenburg</surname>
<given-names>Amy L.</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
<xref ref-type="aff" rid="aff4"><sup>4</sup>
</xref>
<xref ref-type="aff" rid="aff5"><sup>5</sup>
</xref>
<xref ref-type="corresp" rid="cor1"><sup>*</sup>
</xref>
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<aff id="aff1"><label>1</label>
Department of Physics and Astronomy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3255,<country>USA</country>
</aff>
<aff id="aff2"><label>2</label>
Department of Otolaryngology/Head and Neck Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7070,<country>USA</country>
</aff>
<aff id="aff3"><label>3</label>
Physical Sciences Inc., New England Business Center, Andover, MA 01810,<country>USA</country>
</aff>
<aff id="aff4"><label>4</label>
Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7513,<country>USA</country>
</aff>
<aff id="aff5"><label>5</label>
Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7575,<country>USA</country>
</aff>
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<author-notes><corresp id="cor1"><label>*</label>
<email xlink:href="aold@physics.unc.edu">aold@physics.unc.edu</email>
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<pub-date pub-type="epub"><day>19</day>
<month>2</month>
<year>2014</year>
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<pub-date pub-type="collection"><day>01</day>
<month>3</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>19</day>
<month>2</month>
<year>2014</year>
</pub-date>
<pmc-comment> PMC Release delay is 0 months and 0 days and was based on the
. </pmc-comment>
<volume>5</volume>
<issue>3</issue>
<fpage>788</fpage>
<lpage>799</lpage>
<history><date date-type="received"><day>24</day>
<month>12</month>
<year>2013</year>
</date>
<date date-type="rev-recd"><day>03</day>
<month>2</month>
<year>2014</year>
</date>
<date date-type="accepted"><day>03</day>
<month>2</month>
<year>2014</year>
</date>
</history>
<permissions><copyright-statement>© 2014 Optical Society of America</copyright-statement>
<copyright-year>2014</copyright-year>
<copyright-holder>Optical Society of America</copyright-holder>
</permissions>
<abstract><p>Minimally invasive imaging of upper airway obstructions in children and adults is needed to improve clinical decision-making. Toward this goal, we demonstrate an anatomical optical coherence tomography (aOCT) system delivered via a small-bore, flexible endoscope to quantify the upper airway lumen geometry. Helical scans were obtained from a proximally-scanned fiber-optic catheter of 820 μm outer diameter and >2 mm focal length. Coupled with a long coherence length wavelength-swept light source, the system exhibited an SNR roll-off of < 10 dB over a 10 mm range. Operating at 10 rotations/s, the average accuracy of segmented cross-sectional areas was found to be −1.4 ± 1.0%. To demonstrate the capability of this system, aOCT was performed on a pediatric airway phantom and on <italic>ex vivo</italic>
swine trachea. The ability for quantitative endoscopy afforded by this system can aid in diagnosis, medical and surgical decision making, and predictive modeling of upper airway obstructive disorders.</p>
</abstract>
<kwd-group kwd-group-type="OCIS"><title>OCIS codes: </title>
<kwd>(170.4500) Optical coherence tomography</kwd>
<kwd>(170.3880) Medical and biological imaging</kwd>
<kwd>(170.3890) Medical optics instrumentation</kwd>
<kwd>(170.2150) Endoscopic imaging</kwd>
</kwd-group>
<funding-group><award-group id="sp1"><funding-source>National Heart, Lung, and Blood Institute (NHBLI)<named-content content-type="doi">10.13039/100000050</named-content>
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