Effect of high velocity, large amplitude stimuli on the spread of Depolarization in S1 “Barrel” Cortex
Identifieur interne : 001D11 ( Ncbi/Checkpoint ); précédent : 001D10; suivant : 001D12Effect of high velocity, large amplitude stimuli on the spread of Depolarization in S1 “Barrel” Cortex
Auteurs : Douglas J. Davis [États-Unis] ; Robert Sachdev ; Vincent A. Pieribone [États-Unis]Source :
- Somatosensory & motor research [ 0899-0220 ] ; 2011.
Abstract
We examined the effect of large, controlled whisker movements, delivered at a high speed, on the amplitude and spread of depolarization in the anesthetized mouse barrel cortex. The stimulus speed was varied between 1500 to 6000 degrees per second and the extent of movement was varied between 4–16 degrees. The rate of rise of the response was linearly related to the rate of rise of the stimulus. The initial spatial extent of cortical activation was also related to the rate of rise of the stimulus: that is the faster the stimulus onset, the faster the rate of rise of the response, the larger the extent of cortex activated initially. The spatial extent of the response and the rate of rise of the response were not correlated with changes in the deflection amplitude. But slower, longer lasting stimuli produced an Off response, making the actual extent of activation larger for the slowest rising stimuli. These results indicate that the spread of cortical activation depends on stimulus features.
Url:
DOI: 10.3109/08990220.2011.613177
PubMed: 22150170
PubMed Central: 3753103
Affiliations:
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Davis</name><affiliation><nlm:aff id="A1">Interdepartmental Neuroscience Program, Yale University School of Medicine</nlm:aff><wicri:noCountry code="subfield">Yale University School of Medicine</wicri:noCountry></affiliation><affiliation><nlm:aff id="A3">Cellular & Molecular Physiology, Yale University School of Medicine</nlm:aff><wicri:noCountry code="subfield">Yale University School of Medicine</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="A4">The John B. Pierce Laboratory, New Haven CT 06519, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The John B. 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Pieribone</name><affiliation><nlm:aff id="A1">Interdepartmental Neuroscience Program, Yale University School of Medicine</nlm:aff><wicri:noCountry code="subfield">Yale University School of Medicine</wicri:noCountry></affiliation><affiliation><nlm:aff id="A2">Neurobiology, Yale University School of Medicine</nlm:aff><wicri:noCountry code="subfield">Yale University School of Medicine</wicri:noCountry></affiliation><affiliation><nlm:aff id="A3">Cellular & Molecular Physiology, Yale University School of Medicine</nlm:aff><wicri:noCountry code="subfield">Yale University School of Medicine</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="A4">The John B. Pierce Laboratory, New Haven CT 06519, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The John B. Pierce Laboratory, New Haven CT 06519</wicri:regionArea><wicri:noRegion>New Haven CT 06519</wicri:noRegion></affiliation></author></analytic><series><title level="j">Somatosensory & motor research</title><idno type="ISSN">0899-0220</idno><idno type="eISSN">1369-1651</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">We examined the effect of large, controlled whisker movements, delivered at a high speed, on the amplitude and spread of depolarization in the anesthetized mouse barrel cortex. The stimulus speed was varied between 1500 to 6000 degrees per second and the extent of movement was varied between 4–16 degrees. The rate of rise of the response was linearly related to the rate of rise of the stimulus. The initial spatial extent of cortical activation was also related to the rate of rise of the stimulus: that is the faster the stimulus onset, the faster the rate of rise of the response, the larger the extent of cortex activated initially. The spatial extent of the response and the rate of rise of the response were not correlated with changes in the deflection amplitude. But slower, longer lasting stimuli produced an Off response, making the actual extent of activation larger for the slowest rising stimuli. 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