Effect of high velocity, large amplitude stimuli on the spread of Depolarization in S1 “Barrel” Cortex
Identifieur interne : 001A45 ( Pmc/Curation ); précédent : 001A44; suivant : 001A46Effect of high velocity, large amplitude stimuli on the spread of Depolarization in S1 “Barrel” Cortex
Auteurs : Douglas J. Davis [États-Unis] ; Robert Sachdev ; Vincent A. Pieribone [États-Unis]Source :
- Somatosensory & motor research [ 0899-0220 ] ; 2011.
Abstract
We examined the effect of large, controlled whisker movements, delivered at a high speed, on the amplitude and spread of depolarization in the anesthetized mouse barrel cortex. The stimulus speed was varied between 1500 to 6000 degrees per second and the extent of movement was varied between 4–16 degrees. The rate of rise of the response was linearly related to the rate of rise of the stimulus. The initial spatial extent of cortical activation was also related to the rate of rise of the stimulus: that is the faster the stimulus onset, the faster the rate of rise of the response, the larger the extent of cortex activated initially. The spatial extent of the response and the rate of rise of the response were not correlated with changes in the deflection amplitude. But slower, longer lasting stimuli produced an Off response, making the actual extent of activation larger for the slowest rising stimuli. These results indicate that the spread of cortical activation depends on stimulus features.
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DOI: 10.3109/08990220.2011.613177
PubMed: 22150170
PubMed Central: 3753103
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Douglas J. Davis<affiliation><nlm:aff id="A1">Interdepartmental Neuroscience Program, Yale University School of Medicine</nlm:aff><wicri:noCountry code="subfield">Yale University School of Medicine</wicri:noCountry></affiliation><affiliation><nlm:aff id="A3">Cellular & Molecular Physiology, Yale University School of Medicine</nlm:aff><wicri:noCountry code="subfield">Yale University School of Medicine</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="A4">The John B. Pierce Laboratory, New Haven CT 06519, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The John B. Pierce Laboratory, New Haven CT 06519</wicri:regionArea></affiliation><affiliation><nlm:aff id="A3">Cellular & Molecular Physiology, Yale University School of Medicine</nlm:aff><wicri:noCountry code="subfield">Yale University School of Medicine</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="A4">The John B. Pierce Laboratory, New Haven CT 06519, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The John B. Pierce Laboratory, New Haven CT 06519</wicri:regionArea></affiliation><affiliation><nlm:aff id="A2">Neurobiology, Yale University School of Medicine</nlm:aff><wicri:noCountry code="subfield">Yale University School of Medicine</wicri:noCountry></affiliation><affiliation><nlm:aff id="A1">Interdepartmental Neuroscience Program, Yale University School of Medicine</nlm:aff><wicri:noCountry code="subfield">Yale University School of Medicine</wicri:noCountry></affiliation><affiliation><nlm:aff id="A2">Neurobiology, Yale University School of Medicine</nlm:aff><wicri:noCountry code="subfield">Yale University School of Medicine</wicri:noCountry></affiliation><affiliation><nlm:aff id="A3">Cellular & Molecular Physiology, Yale University School of Medicine</nlm:aff><wicri:noCountry code="subfield">Yale University School of Medicine</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="A4">The John B. Pierce Laboratory, New Haven CT 06519, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The John B. Pierce Laboratory, New Haven CT 06519</wicri:regionArea></affiliation><affiliation><nlm:aff id="A2">Neurobiology, Yale University School of Medicine</nlm:aff><wicri:noCountry code="subfield">Yale University School of Medicine</wicri:noCountry></affiliation><affiliation><nlm:aff id="A3">Cellular & Molecular Physiology, Yale University School of Medicine</nlm:aff><wicri:noCountry code="subfield">Yale University School of Medicine</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="A4">The John B. Pierce Laboratory, New Haven CT 06519, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The John B. Pierce Laboratory, New Haven CT 06519</wicri:regionArea></affiliation><affiliation><nlm:aff id="A3">Cellular & Molecular Physiology, Yale University School of Medicine</nlm:aff><wicri:noCountry code="subfield">Yale University School of Medicine</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="A4">The John B. Pierce Laboratory, New Haven CT 06519, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The John B. Pierce Laboratory, New Haven CT 06519</wicri:regionArea></affiliation>Le document en format XML
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Pieribone</name><affiliation><nlm:aff id="A1">Interdepartmental Neuroscience Program, Yale University School of Medicine</nlm:aff><wicri:noCountry code="subfield">Yale University School of Medicine</wicri:noCountry></affiliation><affiliation><nlm:aff id="A2">Neurobiology, Yale University School of Medicine</nlm:aff><wicri:noCountry code="subfield">Yale University School of Medicine</wicri:noCountry></affiliation><affiliation><nlm:aff id="A3">Cellular & Molecular Physiology, Yale University School of Medicine</nlm:aff><wicri:noCountry code="subfield">Yale University School of Medicine</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="A4">The John B. Pierce Laboratory, New Haven CT 06519, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The John B. 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The initial spatial extent of cortical activation was also related to the rate of rise of the stimulus: that is the faster the stimulus onset, the faster the rate of rise of the response, the larger the extent of cortex activated initially. The spatial extent of the response and the rate of rise of the response were not correlated with changes in the deflection amplitude. But slower, longer lasting stimuli produced an Off response, making the actual extent of activation larger for the slowest rising stimuli. These results indicate that the spread of cortical activation depends on stimulus features.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">8904127</journal-id><journal-id journal-id-type="pubmed-jr-id">8272</journal-id><journal-id journal-id-type="nlm-ta">Somatosens Mot Res</journal-id><journal-id journal-id-type="iso-abbrev">Somatosens Mot Res</journal-id><journal-title-group><journal-title>Somatosensory & motor research</journal-title></journal-title-group><issn pub-type="ppub">0899-0220</issn><issn pub-type="epub">1369-1651</issn></journal-meta><article-meta><article-id pub-id-type="pmid">22150170</article-id><article-id pub-id-type="pmc">3753103</article-id><article-id pub-id-type="doi">10.3109/08990220.2011.613177</article-id><article-id pub-id-type="manuscript">NIHMS494098</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Effect of high velocity, large amplitude stimuli on the spread of Depolarization in S1 “Barrel” Cortex</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Davis</surname><given-names>Douglas J.</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A3">3</xref><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Sachdev</surname><given-names>Robert</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Pieribone</surname><given-names>Vincent A.</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A3">3</xref><xref ref-type="aff" rid="A4">4</xref></contrib></contrib-group><aff id="A1"><label>1</label>Interdepartmental Neuroscience Program, Yale University School of Medicine</aff><aff id="A2"><label>2</label>Neurobiology, Yale University School of Medicine</aff><aff id="A3"><label>3</label>Cellular & Molecular Physiology, Yale University School of Medicine</aff><aff id="A4"><label>4</label>The John B. Pierce Laboratory, New Haven CT 06519, USA</aff><author-notes><corresp id="FN1">Corresponding author address: Vincent A. Pieribone, Ph.D., The John B. Pierce Laboratory, 290 Congress Avenue, New Haven, CT 06519; <email>Vpieribo@jbpierce.org</email>. Robert Sachdev, Yale School of Medicine, Dept of Neurobiology, <email>Robert.N.S.Sachdev@yale.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>22</day><month>7</month><year>2013</year></pub-date><pub-date pub-type="epub"><day>13</day><month>12</month><year>2011</year></pub-date><pub-date pub-type="ppub"><year>2011</year></pub-date><pub-date pub-type="pmc-release"><day>26</day><month>8</month><year>2013</year></pub-date><volume>28</volume><issue>0</issue><fpage>73</fpage><lpage>85</lpage><abstract><p id="P1">We examined the effect of large, controlled whisker movements, delivered at a high speed, on the amplitude and spread of depolarization in the anesthetized mouse barrel cortex. The stimulus speed was varied between 1500 to 6000 degrees per second and the extent of movement was varied between 4–16 degrees. The rate of rise of the response was linearly related to the rate of rise of the stimulus. The initial spatial extent of cortical activation was also related to the rate of rise of the stimulus: that is the faster the stimulus onset, the faster the rate of rise of the response, the larger the extent of cortex activated initially. The spatial extent of the response and the rate of rise of the response were not correlated with changes in the deflection amplitude. But slower, longer lasting stimuli produced an Off response, making the actual extent of activation larger for the slowest rising stimuli. These results indicate that the spread of cortical activation depends on stimulus features.</p></abstract><funding-group><award-group><funding-source country="United States">National Institute of Mental Health : NIMH</funding-source><award-id>R21 MH064214 || MH</award-id></award-group></funding-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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