BDNF Val66Met Polymorphism Influences Motor System Function in the Human Brain
Identifieur interne : 003937 ( Main/Curation ); précédent : 003936; suivant : 003938BDNF Val66Met Polymorphism Influences Motor System Function in the Human Brain
Auteurs : Stephanie A. Mchughen ; Paul F. Rodriguez [États-Unis] ; Jeffrey A. Kleim ; Erin D. Kleim ; Laura Marchal Crespo ; Vincent Procaccio ; Steven C. Cramer [États-Unis]Source :
- Cerebral Cortex [ 1047-3211 ] ; 2009-09-10.
Abstract
Brain-derived neurotrophic factor (BDNF) is important to brain functions such as plasticity and repair. A single nucleotide polymorphism for this growth factor, val66met, is common and associated with decreased activity-dependent BDNF release. The current study evaluated the effects of this polymorphism in relation to human brain motor system function, short-term plasticity, and learning. Functional magnetic resonance imaging (fMRI) scanning during right index finger movement (n24) identified activation in a broad sensorimotor network. However, subjects with the polymorphism showed smaller activation volume within several brain regions as compared with subjects without the polymorphism. Repeat fMRI after 25 min of right index finger training found that the 2 genotype groups modulated brain activation differently. In several brain regions, subjects with the polymorphism showed greater activation volume reduction, whereas subjects without the polymorphism showed greater activation volume expansion. On a driving-based motor learning task (independent cohort, n29), subjects with the polymorphism showed greater error during short-term learning and poorer retention over 4 days, relative to subjects without the polymorphism. The presence of this BDNF polymorphism is associated with differences in brain motor system function, altered short-term plasticity, and greater error in short-term motor learning. The broader implications of these findings are considered.
Url:
- https://api.istex.fr/document/08F1F520873FAB65522D40A8F3E8D727073CB6A0/fulltext/pdf
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2852510
DOI: 10.1093/cercor/bhp189
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: Pour aller vers cette notice dans l'étape Curation :002679
- to stream Istex, to step Curation: Pour aller vers cette notice dans l'étape Curation :002679
- to stream Istex, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000734
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :001332
- to stream Pmc, to step Curation: Pour aller vers cette notice dans l'étape Curation :001332
- to stream Pmc, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :002201
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :001260
- to stream Ncbi, to step Curation: Pour aller vers cette notice dans l'étape Curation :001260
- to stream Ncbi, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :001260
- to stream Main, to step Merge: Pour aller vers cette notice dans l'étape Curation :003995
Links to Exploration step
ISTEX:08F1F520873FAB65522D40A8F3E8D727073CB6A0Curation
No country items
Stephanie A. Mchughen<affiliation><wicri:noCountry code="no comma">Department of Anatomy and Neurobiology</wicri:noCountry></affiliation><affiliation><wicri:noCountry code="subField">Departments of</wicri:noCountry></affiliation><affiliation><wicri:noCountry code="subField">Departments of</wicri:noCountry></affiliation><affiliation><wicri:noCountry code="no comma">Mechanical & Aerospace Engineering</wicri:noCountry></affiliation><affiliation><wicri:noCountry code="no comma">Pediatrics (Human Genetics Division and Metabolism)</wicri:noCountry></affiliation><affiliation><wicri:noCountry code="no comma">Department of Anatomy and Neurobiology</wicri:noCountry></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Neurology, University of California, Irvine, CA 92697</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation><affiliation wicri:level="1"><country wicri:rule="url">États-Unis</country></affiliation>Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>BDNF Val66Met Polymorphism Influences Motor System Function in the Human Brain</title><author><name sortKey="Mchughen, Stephanie A" sort="Mchughen, Stephanie A" uniqKey="Mchughen S" first="Stephanie A." last="Mchughen">Stephanie A. Mchughen</name></author><author><name sortKey="Rodriguez, Paul F" sort="Rodriguez, Paul F" uniqKey="Rodriguez P" first="Paul F." last="Rodriguez">Paul F. Rodriguez</name></author><author><name sortKey="Kleim, Jeffrey A" sort="Kleim, Jeffrey A" uniqKey="Kleim J" first="Jeffrey A." last="Kleim">Jeffrey A. Kleim</name></author><author><name sortKey="Kleim, Erin D" sort="Kleim, Erin D" uniqKey="Kleim E" first="Erin D." last="Kleim">Erin D. Kleim</name></author><author><name sortKey="Crespo, Laura Marchal" sort="Crespo, Laura Marchal" uniqKey="Crespo L" first="Laura Marchal" last="Crespo">Laura Marchal Crespo</name></author><author><name sortKey="Procaccio, Vincent" sort="Procaccio, Vincent" uniqKey="Procaccio V" first="Vincent" last="Procaccio">Vincent Procaccio</name></author><author><name sortKey="Cramer, Steven C" sort="Cramer, Steven C" uniqKey="Cramer S" first="Steven C." last="Cramer">Steven C. Cramer</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:08F1F520873FAB65522D40A8F3E8D727073CB6A0</idno><date when="2010" year="2010">2010</date><idno type="doi">10.1093/cercor/bhp189</idno><idno type="url">https://api.istex.fr/document/08F1F520873FAB65522D40A8F3E8D727073CB6A0/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">002679</idno><idno type="wicri:Area/Istex/Curation">002679</idno><idno type="wicri:Area/Istex/Checkpoint">000734</idno><idno type="wicri:doubleKey">1047-3211:2010:Mchughen S:bdnf:val:met</idno><idno type="wicri:source">PMC</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2852510</idno><idno type="RBID">PMC:2852510</idno><idno type="wicri:Area/Pmc/Corpus">001332</idno><idno type="wicri:Area/Pmc/Curation">001332</idno><idno type="wicri:Area/Pmc/Checkpoint">002201</idno><idno type="wicri:Area/Ncbi/Merge">001260</idno><idno type="wicri:Area/Ncbi/Curation">001260</idno><idno type="wicri:Area/Ncbi/Checkpoint">001260</idno><idno type="wicri:Area/Main/Merge">003995</idno><idno type="wicri:Area/Main/Curation">003937</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">BDNF Val66Met Polymorphism Influences Motor System Function in the Human Brain</title><author><name sortKey="Mchughen, Stephanie A" sort="Mchughen, Stephanie A" uniqKey="Mchughen S" first="Stephanie A." last="Mchughen">Stephanie A. Mchughen</name><affiliation><wicri:noCountry code="no comma">Department of Anatomy and Neurobiology</wicri:noCountry></affiliation></author><author><name sortKey="Rodriguez, Paul F" sort="Rodriguez, Paul F" uniqKey="Rodriguez P" first="Paul F." last="Rodriguez">Paul F. Rodriguez</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Cognitive Science, University of California, Irvine, CA 92697</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Kleim, Jeffrey A" sort="Kleim, Jeffrey A" uniqKey="Kleim J" first="Jeffrey A." last="Kleim">Jeffrey A. Kleim</name><affiliation><wicri:noCountry code="subField">Departments of</wicri:noCountry></affiliation></author><author><name sortKey="Kleim, Erin D" sort="Kleim, Erin D" uniqKey="Kleim E" first="Erin D." last="Kleim">Erin D. Kleim</name><affiliation><wicri:noCountry code="subField">Departments of</wicri:noCountry></affiliation></author><author><name sortKey="Crespo, Laura Marchal" sort="Crespo, Laura Marchal" uniqKey="Crespo L" first="Laura Marchal" last="Crespo">Laura Marchal Crespo</name><affiliation><wicri:noCountry code="no comma">Mechanical & Aerospace Engineering</wicri:noCountry></affiliation></author><author><name sortKey="Procaccio, Vincent" sort="Procaccio, Vincent" uniqKey="Procaccio V" first="Vincent" last="Procaccio">Vincent Procaccio</name><affiliation><wicri:noCountry code="no comma">Pediatrics (Human Genetics Division and Metabolism)</wicri:noCountry></affiliation></author><author><name sortKey="Cramer, Steven C" sort="Cramer, Steven C" uniqKey="Cramer S" first="Steven C." last="Cramer">Steven C. Cramer</name><affiliation><wicri:noCountry code="no comma">Department of Anatomy and Neurobiology</wicri:noCountry></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Neurology, University of California, Irvine, CA 92697</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation><affiliation wicri:level="1"><country wicri:rule="url">États-Unis</country></affiliation></author></analytic><monogr></monogr><series><title level="j">Cerebral Cortex</title><idno type="ISSN">1047-3211</idno><idno type="eISSN">1460-2199</idno><imprint><publisher>Oxford University Press</publisher><date type="published" when="2009-09-10">2009-09-10</date><biblScope unit="volume">20</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="1254">1254</biblScope><biblScope unit="page" to="1262">1262</biblScope></imprint><idno type="ISSN">1047-3211</idno></series><idno type="istex">08F1F520873FAB65522D40A8F3E8D727073CB6A0</idno><idno type="DOI">10.1093/cercor/bhp189</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1047-3211</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Brain-derived neurotrophic factor (BDNF) is important to brain functions such as plasticity and repair. A single nucleotide polymorphism for this growth factor, val66met, is common and associated with decreased activity-dependent BDNF release. The current study evaluated the effects of this polymorphism in relation to human brain motor system function, short-term plasticity, and learning. Functional magnetic resonance imaging (fMRI) scanning during right index finger movement (n24) identified activation in a broad sensorimotor network. However, subjects with the polymorphism showed smaller activation volume within several brain regions as compared with subjects without the polymorphism. Repeat fMRI after 25 min of right index finger training found that the 2 genotype groups modulated brain activation differently. In several brain regions, subjects with the polymorphism showed greater activation volume reduction, whereas subjects without the polymorphism showed greater activation volume expansion. On a driving-based motor learning task (independent cohort, n29), subjects with the polymorphism showed greater error during short-term learning and poorer retention over 4 days, relative to subjects without the polymorphism. The presence of this BDNF polymorphism is associated with differences in brain motor system function, altered short-term plasticity, and greater error in short-term motor learning. The broader implications of these findings are considered.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Ticri/CIDE/explor/HapticV1/Data/Main/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003937 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Curation/biblio.hfd -nk 003937 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Ticri/CIDE
|area= HapticV1
|flux= Main
|étape= Curation
|type= RBID
|clé= ISTEX:08F1F520873FAB65522D40A8F3E8D727073CB6A0
|texte= BDNF Val66Met Polymorphism Influences Motor System Function in the Human Brain
}}
| This area was generated with Dilib version V0.6.23. |  |