BDNF Val66Met Polymorphism Influences Motor System Function in the Human Brain
Identifieur interne : 002679 ( Istex/Corpus ); précédent : 002678; suivant : 002680BDNF Val66Met Polymorphism Influences Motor System Function in the Human Brain
Auteurs : Stephanie A. Mchughen ; Paul F. Rodriguez ; Jeffrey A. Kleim ; Erin D. Kleim ; Laura Marchal Crespo ; Vincent Procaccio ; Steven C. CramerSource :
- Cerebral Cortex [ 1047-3211 ] ; 2009-09-10.
Abstract
Brain-derived neurotrophic factor (BDNF) is important to brain functions such as plasticity and repair. A single nucleotide polymorphism for this growth factor, val66met, is common and associated with decreased activity-dependent BDNF release. The current study evaluated the effects of this polymorphism in relation to human brain motor system function, short-term plasticity, and learning. Functional magnetic resonance imaging (fMRI) scanning during right index finger movement (n24) identified activation in a broad sensorimotor network. However, subjects with the polymorphism showed smaller activation volume within several brain regions as compared with subjects without the polymorphism. Repeat fMRI after 25 min of right index finger training found that the 2 genotype groups modulated brain activation differently. In several brain regions, subjects with the polymorphism showed greater activation volume reduction, whereas subjects without the polymorphism showed greater activation volume expansion. On a driving-based motor learning task (independent cohort, n29), subjects with the polymorphism showed greater error during short-term learning and poorer retention over 4 days, relative to subjects without the polymorphism. The presence of this BDNF polymorphism is associated with differences in brain motor system function, altered short-term plasticity, and greater error in short-term motor learning. The broader implications of these findings are considered.
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DOI: 10.1093/cercor/bhp189
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<front><div type="abstract">Brain-derived neurotrophic factor (BDNF) is important to brain functions such as plasticity and repair. A single nucleotide polymorphism for this growth factor, val66met, is common and associated with decreased activity-dependent BDNF release. The current study evaluated the effects of this polymorphism in relation to human brain motor system function, short-term plasticity, and learning. Functional magnetic resonance imaging (fMRI) scanning during right index finger movement (n24) identified activation in a broad sensorimotor network. However, subjects with the polymorphism showed smaller activation volume within several brain regions as compared with subjects without the polymorphism. Repeat fMRI after 25 min of right index finger training found that the 2 genotype groups modulated brain activation differently. In several brain regions, subjects with the polymorphism showed greater activation volume reduction, whereas subjects without the polymorphism showed greater activation volume expansion. On a driving-based motor learning task (independent cohort, n29), subjects with the polymorphism showed greater error during short-term learning and poorer retention over 4 days, relative to subjects without the polymorphism. The presence of this BDNF polymorphism is associated with differences in brain motor system function, altered short-term plasticity, and greater error in short-term motor learning. The broader implications of these findings are considered.</div>
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<aff id="aff1"><label>1</label>
Department of Anatomy and Neurobiology</aff>
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Department of Cognitive Science, University of California, Irvine, CA 92697, USA</aff>
<aff id="aff3"><label>3</label>
Department of Neuroscience, McKnight Brain Institute, University of Florida, Brain Rehabilitation Research Center, Malcom Randall VA Hospital, Gainesville, FL 32610-0244, USA, Departments of</aff>
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Mechanical & Aerospace Engineering</aff>
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<author-notes><corresp>Address correspondence to Dr Steven C. Cramer, MD, University of California Irvine Medical Center, 101Š The City Drive South, Building 53, Room 203, Orange, CA 92868-4280, USA. Email: <email>scramer@uci.edu</email>
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<abstract><p>Brain-derived neurotrophic factor (BDNF) is important to brain functions such as plasticity and repair. A single nucleotide polymorphism for this growth factor, val<sup>66</sup>
met, is common and associated with decreased activity-dependent BDNF release. The current study evaluated the effects of this polymorphism in relation to human brain motor system function, short-term plasticity, and learning. Functional magnetic resonance imaging (fMRI) scanning during right index finger movement (<italic>n</italic>
= 24) identified activation in a broad sensorimotor network. However, subjects with the polymorphism showed smaller activation volume within several brain regions as compared with subjects without the polymorphism. Repeat fMRI after 25 min of right index finger training found that the 2 genotype groups modulated brain activation differently. In several brain regions, subjects with the polymorphism showed greater activation volume reduction, whereas subjects without the polymorphism showed greater activation volume expansion. On a driving-based motor learning task (independent cohort, <italic>n</italic>
= 29), subjects with the polymorphism showed greater error during short-term learning and poorer retention over 4 days, relative to subjects without the polymorphism. The presence of this BDNF polymorphism is associated with differences in brain motor system function, altered short-term plasticity, and greater error in short-term motor learning. The broader implications of these findings are considered.</p>
</abstract>
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<name type="personal"><namePart type="given">Stephanie A.</namePart>
<namePart type="family">McHughen</namePart>
<affiliation>Department of Anatomy and Neurobiology</affiliation>
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<name type="personal"><namePart type="given">Paul F.</namePart>
<namePart type="family">Rodriguez</namePart>
<affiliation>Department of Cognitive Science, University of California, Irvine, CA 92697, USA</affiliation>
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<name type="personal"><namePart type="given">Jeffrey A.</namePart>
<namePart type="family">Kleim</namePart>
<affiliation>Department of Neuroscience, McKnight Brain Institute, University of Florida, Brain Rehabilitation Research Center, Malcom Randall VA Hospital, Gainesville, FL 32610-0244, USA, Departments of</affiliation>
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<name type="personal"><namePart type="given">Erin D.</namePart>
<namePart type="family">Kleim</namePart>
<affiliation>Department of Neuroscience, McKnight Brain Institute, University of Florida, Brain Rehabilitation Research Center, Malcom Randall VA Hospital, Gainesville, FL 32610-0244, USA, Departments of</affiliation>
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<name type="personal"><namePart type="given">Laura Marchal</namePart>
<namePart type="family">Crespo</namePart>
<affiliation>Mechanical & Aerospace Engineering</affiliation>
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<name type="personal"><namePart type="given">Vincent</namePart>
<namePart type="family">Procaccio</namePart>
<affiliation>Pediatrics (Human Genetics Division and Metabolism)</affiliation>
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<name type="personal" displayLabel="corresp"><namePart type="given">Steven C.</namePart>
<namePart type="family">Cramer</namePart>
<affiliation>Department of Anatomy and Neurobiology</affiliation>
<affiliation>Neurology, University of California, Irvine, CA 92697, USA</affiliation>
<affiliation>E-mail: scramer@uci.edu</affiliation>
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<dateIssued encoding="w3cdtf">2009-09-10</dateIssued>
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<abstract>Brain-derived neurotrophic factor (BDNF) is important to brain functions such as plasticity and repair. A single nucleotide polymorphism for this growth factor, val66met, is common and associated with decreased activity-dependent BDNF release. The current study evaluated the effects of this polymorphism in relation to human brain motor system function, short-term plasticity, and learning. Functional magnetic resonance imaging (fMRI) scanning during right index finger movement (n24) identified activation in a broad sensorimotor network. However, subjects with the polymorphism showed smaller activation volume within several brain regions as compared with subjects without the polymorphism. Repeat fMRI after 25 min of right index finger training found that the 2 genotype groups modulated brain activation differently. In several brain regions, subjects with the polymorphism showed greater activation volume reduction, whereas subjects without the polymorphism showed greater activation volume expansion. On a driving-based motor learning task (independent cohort, n29), subjects with the polymorphism showed greater error during short-term learning and poorer retention over 4 days, relative to subjects without the polymorphism. The presence of this BDNF polymorphism is associated with differences in brain motor system function, altered short-term plasticity, and greater error in short-term motor learning. The broader implications of these findings are considered.</abstract>
<subject><genre>Keywords</genre>
<topic>cortex</topic>
<topic>fMRI</topic>
<topic>genetics</topic>
<topic>genotype</topic>
<topic>plasticity</topic>
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<relatedItem type="host"><titleInfo><title>Cerebral Cortex</title>
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<identifier type="ISSN">1047-3211</identifier>
<identifier type="eISSN">1460-2199</identifier>
<identifier type="PublisherID">cercor</identifier>
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<part><date>2009</date>
<detail type="volume"><caption>vol.</caption>
<number>20</number>
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<detail type="issue"><caption>no.</caption>
<number>5</number>
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<extent unit="pages"><start>1254</start>
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<identifier type="DOI">10.1093/cercor/bhp189</identifier>
<accessCondition type="use and reproduction" contentType="copyright">The Author 2009. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org</accessCondition>
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