Blunted cortisol responses to psychosocial stress in asthmatic children: a general feature of atopic disease?
Identifieur interne : 003836 ( Main/Exploration ); précédent : 003835; suivant : 003837Blunted cortisol responses to psychosocial stress in asthmatic children: a general feature of atopic disease?
Auteurs : Angelika Buske-Kirschbaum [Allemagne] ; Kristin Von Auer ; Silke Krieger ; Stefan Weis ; Wolfgang Rauh ; Dirk HellhammerSource :
- Psychosomatic medicine [ 1534-7796 ]
English descriptors
- KwdEn :
- Adrenal Cortex (secretion), Asthma (complications), Asthma (physiopathology), Asthma (psychology), Child, Circadian Rhythm, Female, Heart Rate, Humans, Hydrocortisone (analysis), Hydrocortisone (secretion), Hypersensitivity, Immediate (complications), Hypersensitivity, Immediate (physiopathology), Hypersensitivity, Immediate (psychology), Hypothalamo-Hypophyseal System (physiopathology), Male, Pituitary-Adrenal System (physiopathology), Saliva (chemistry), Stress, Psychological (complications), Stress, Psychological (physiopathology), Surveys and Questionnaires.
- MESH :
- chemical , analysis : Hydrocortisone.
- chemistry : Saliva.
- complications : Asthma, Hypersensitivity, Immediate, Stress, Psychological.
- physiopathology : Asthma, Hypersensitivity, Immediate, Hypothalamo-Hypophyseal System, Pituitary-Adrenal System, Stress, Psychological.
- psychology : Asthma, Hypersensitivity, Immediate.
- secretion : Adrenal Cortex, Hydrocortisone.
- Child, Circadian Rhythm, Female, Heart Rate, Humans, Male, Surveys and Questionnaires.
Abstract
Atopy is defined by the individual predisposition to develop a group of inflammatory disorders in response to certain food or environmental substances that are otherwise innocuous for the host. In previous studies we could demonstrate a reduced responsiveness of the hypothalamus-pituitary-adrenal (HPA) axis to psychosocial stress in young and adult patients with atopic dermatitis (AD), a chronic atopic skin disorder. With respect to the important immunoregulatory role of the HPA axis, especially under stress, this observation could be of clinical relevance and may at least partly explain stress-induced exacerbation of AD. The present study was designed to investigate whether attenuated responsiveness of the HPA axis to stress represents a characteristic feature of AD or whether it can also be found in other chronic manifestations of atopy.
PubMed: 14508024
Affiliations:
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Le document en format XML
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<front><div type="abstract" xml:lang="en">Atopy is defined by the individual predisposition to develop a group of inflammatory disorders in response to certain food or environmental substances that are otherwise innocuous for the host. In previous studies we could demonstrate a reduced responsiveness of the hypothalamus-pituitary-adrenal (HPA) axis to psychosocial stress in young and adult patients with atopic dermatitis (AD), a chronic atopic skin disorder. With respect to the important immunoregulatory role of the HPA axis, especially under stress, this observation could be of clinical relevance and may at least partly explain stress-induced exacerbation of AD. The present study was designed to investigate whether attenuated responsiveness of the HPA axis to stress represents a characteristic feature of AD or whether it can also be found in other chronic manifestations of atopy.</div>
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<name sortKey="Krieger, Silke" sort="Krieger, Silke" uniqKey="Krieger S" first="Silke" last="Krieger">Silke Krieger</name>
<name sortKey="Rauh, Wolfgang" sort="Rauh, Wolfgang" uniqKey="Rauh W" first="Wolfgang" last="Rauh">Wolfgang Rauh</name>
<name sortKey="Von Auer, Kristin" sort="Von Auer, Kristin" uniqKey="Von Auer K" first="Kristin" last="Von Auer">Kristin Von Auer</name>
<name sortKey="Weis, Stefan" sort="Weis, Stefan" uniqKey="Weis S" first="Stefan" last="Weis">Stefan Weis</name>
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