Blunted cortisol responses to psychosocial stress in asthmatic children: a general feature of atopic disease?
Identifieur interne : 000769 ( PubMed/Corpus ); précédent : 000768; suivant : 000770Blunted cortisol responses to psychosocial stress in asthmatic children: a general feature of atopic disease?
Auteurs : Angelika Buske-Kirschbaum ; Kristin Von Auer ; Silke Krieger ; Stefan Weis ; Wolfgang Rauh ; Dirk HellhammerSource :
- Psychosomatic medicine [ 1534-7796 ]
English descriptors
- KwdEn :
- Adrenal Cortex (secretion), Asthma (complications), Asthma (physiopathology), Asthma (psychology), Child, Circadian Rhythm, Female, Heart Rate, Humans, Hydrocortisone (analysis), Hydrocortisone (secretion), Hypersensitivity, Immediate (complications), Hypersensitivity, Immediate (physiopathology), Hypersensitivity, Immediate (psychology), Hypothalamo-Hypophyseal System (physiopathology), Male, Pituitary-Adrenal System (physiopathology), Saliva (chemistry), Stress, Psychological (complications), Stress, Psychological (physiopathology), Surveys and Questionnaires.
- MESH :
- chemical , analysis : Hydrocortisone.
- chemistry : Saliva.
- complications : Asthma, Hypersensitivity, Immediate, Stress, Psychological.
- physiopathology : Asthma, Hypersensitivity, Immediate, Hypothalamo-Hypophyseal System, Pituitary-Adrenal System, Stress, Psychological.
- psychology : Asthma, Hypersensitivity, Immediate.
- secretion : Adrenal Cortex, Hydrocortisone.
- Child, Circadian Rhythm, Female, Heart Rate, Humans, Male, Surveys and Questionnaires.
Abstract
Atopy is defined by the individual predisposition to develop a group of inflammatory disorders in response to certain food or environmental substances that are otherwise innocuous for the host. In previous studies we could demonstrate a reduced responsiveness of the hypothalamus-pituitary-adrenal (HPA) axis to psychosocial stress in young and adult patients with atopic dermatitis (AD), a chronic atopic skin disorder. With respect to the important immunoregulatory role of the HPA axis, especially under stress, this observation could be of clinical relevance and may at least partly explain stress-induced exacerbation of AD. The present study was designed to investigate whether attenuated responsiveness of the HPA axis to stress represents a characteristic feature of AD or whether it can also be found in other chronic manifestations of atopy.
PubMed: 14508024
Links to Exploration step
pubmed:14508024Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Blunted cortisol responses to psychosocial stress in asthmatic children: a general feature of atopic disease?</title><author><name sortKey="Buske Kirschbaum, Angelika" sort="Buske Kirschbaum, Angelika" uniqKey="Buske Kirschbaum A" first="Angelika" last="Buske-Kirschbaum">Angelika Buske-Kirschbaum</name><affiliation><nlm:affiliation>Department of Psychobiology, Center for Psychobiological and Psychosomatic Research, University of Trier, Trier, Germany. buske@uni-trier.de</nlm:affiliation></affiliation></author><author><name sortKey="Von Auer, Kristin" sort="Von Auer, Kristin" uniqKey="Von Auer K" first="Kristin" last="Von Auer">Kristin Von Auer</name></author><author><name sortKey="Krieger, Silke" sort="Krieger, Silke" uniqKey="Krieger S" first="Silke" last="Krieger">Silke Krieger</name></author><author><name sortKey="Weis, Stefan" sort="Weis, Stefan" uniqKey="Weis S" first="Stefan" last="Weis">Stefan Weis</name></author><author><name sortKey="Rauh, Wolfgang" sort="Rauh, Wolfgang" uniqKey="Rauh W" first="Wolfgang" last="Rauh">Wolfgang Rauh</name></author><author><name sortKey="Hellhammer, Dirk" sort="Hellhammer, Dirk" uniqKey="Hellhammer D" first="Dirk" last="Hellhammer">Dirk Hellhammer</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="????"><PubDate><MedlineDate>2003 Sep-Oct</MedlineDate></PubDate></date><idno type="RBID">pubmed:14508024</idno><idno type="pmid">14508024</idno><idno type="wicri:Area/PubMed/Corpus">000769</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000769</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Blunted cortisol responses to psychosocial stress in asthmatic children: a general feature of atopic disease?</title><author><name sortKey="Buske Kirschbaum, Angelika" sort="Buske Kirschbaum, Angelika" uniqKey="Buske Kirschbaum A" first="Angelika" last="Buske-Kirschbaum">Angelika Buske-Kirschbaum</name><affiliation><nlm:affiliation>Department of Psychobiology, Center for Psychobiological and Psychosomatic Research, University of Trier, Trier, Germany. buske@uni-trier.de</nlm:affiliation></affiliation></author><author><name sortKey="Von Auer, Kristin" sort="Von Auer, Kristin" uniqKey="Von Auer K" first="Kristin" last="Von Auer">Kristin Von Auer</name></author><author><name sortKey="Krieger, Silke" sort="Krieger, Silke" uniqKey="Krieger S" first="Silke" last="Krieger">Silke Krieger</name></author><author><name sortKey="Weis, Stefan" sort="Weis, Stefan" uniqKey="Weis S" first="Stefan" last="Weis">Stefan Weis</name></author><author><name sortKey="Rauh, Wolfgang" sort="Rauh, Wolfgang" uniqKey="Rauh W" first="Wolfgang" last="Rauh">Wolfgang Rauh</name></author><author><name sortKey="Hellhammer, Dirk" sort="Hellhammer, Dirk" uniqKey="Hellhammer D" first="Dirk" last="Hellhammer">Dirk Hellhammer</name></author></analytic><series><title level="j">Psychosomatic medicine</title><idno type="eISSN">1534-7796</idno></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adrenal Cortex (secretion)</term><term>Asthma (complications)</term><term>Asthma (physiopathology)</term><term>Asthma (psychology)</term><term>Child</term><term>Circadian Rhythm</term><term>Female</term><term>Heart Rate</term><term>Humans</term><term>Hydrocortisone (analysis)</term><term>Hydrocortisone (secretion)</term><term>Hypersensitivity, Immediate (complications)</term><term>Hypersensitivity, Immediate (physiopathology)</term><term>Hypersensitivity, Immediate (psychology)</term><term>Hypothalamo-Hypophyseal System (physiopathology)</term><term>Male</term><term>Pituitary-Adrenal System (physiopathology)</term><term>Saliva (chemistry)</term><term>Stress, Psychological (complications)</term><term>Stress, Psychological (physiopathology)</term><term>Surveys and Questionnaires</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Hydrocortisone</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Saliva</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Asthma</term><term>Hypersensitivity, Immediate</term><term>Stress, Psychological</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Asthma</term><term>Hypersensitivity, Immediate</term><term>Hypothalamo-Hypophyseal System</term><term>Pituitary-Adrenal System</term><term>Stress, Psychological</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Asthma</term><term>Hypersensitivity, Immediate</term></keywords><keywords scheme="MESH" qualifier="secretion" xml:lang="en"><term>Adrenal Cortex</term><term>Hydrocortisone</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Child</term><term>Circadian Rhythm</term><term>Female</term><term>Heart Rate</term><term>Humans</term><term>Male</term><term>Surveys and Questionnaires</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Atopy is defined by the individual predisposition to develop a group of inflammatory disorders in response to certain food or environmental substances that are otherwise innocuous for the host. In previous studies we could demonstrate a reduced responsiveness of the hypothalamus-pituitary-adrenal (HPA) axis to psychosocial stress in young and adult patients with atopic dermatitis (AD), a chronic atopic skin disorder. With respect to the important immunoregulatory role of the HPA axis, especially under stress, this observation could be of clinical relevance and may at least partly explain stress-induced exacerbation of AD. The present study was designed to investigate whether attenuated responsiveness of the HPA axis to stress represents a characteristic feature of AD or whether it can also be found in other chronic manifestations of atopy.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">14508024</PMID><DateCreated><Year>2003</Year><Month>09</Month><Day>25</Day></DateCreated><DateCompleted><Year>2004</Year><Month>04</Month><Day>15</Day></DateCompleted><DateRevised><Year>2015</Year><Month>11</Month><Day>19</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1534-7796</ISSN><JournalIssue CitedMedium="Internet"><Volume>65</Volume><Issue>5</Issue><PubDate><MedlineDate>2003 Sep-Oct</MedlineDate></PubDate></JournalIssue><Title>Psychosomatic medicine</Title><ISOAbbreviation>Psychosom Med</ISOAbbreviation></Journal><ArticleTitle>Blunted cortisol responses to psychosocial stress in asthmatic children: a general feature of atopic disease?</ArticleTitle><Pagination><MedlinePgn>806-10</MedlinePgn></Pagination><Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">Atopy is defined by the individual predisposition to develop a group of inflammatory disorders in response to certain food or environmental substances that are otherwise innocuous for the host. In previous studies we could demonstrate a reduced responsiveness of the hypothalamus-pituitary-adrenal (HPA) axis to psychosocial stress in young and adult patients with atopic dermatitis (AD), a chronic atopic skin disorder. With respect to the important immunoregulatory role of the HPA axis, especially under stress, this observation could be of clinical relevance and may at least partly explain stress-induced exacerbation of AD. The present study was designed to investigate whether attenuated responsiveness of the HPA axis to stress represents a characteristic feature of AD or whether it can also be found in other chronic manifestations of atopy.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Children (aged 7-12) with allergic asthma (AA; N = 17) and age- and sex-matched healthy controls (N = 18) were exposed to the "Trier Social Stress Test for Children"(TSST-C), which mainly consists of a free speech and mental arithmetic tasks in front of an audience. Salivary cortisol was measured in ten-minute intervals before and after the TSST-C, while heart rate was monitored continuously. In addition, early morning cortisol levels (after awakening, +10, +20, +30 minutes) were assessed on three consecutive days.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Data analysis yielded a significant increase of cortisol concentrations (F (9297)= 16.79; p <.001) and heart rates (F(32,992)= 9.16; p <.001) after the stressor with no between-group difference in heart rate responses. However, AA children showed a significantly blunted cortisol response to the TSST-C when compared with the control group (F(9297)= 2.95; p <.01). Awakening in the morning was accompanied by a significant rise of cortisol levels on all three experimental days in AA and control subjects (all p <.001) that was not different between the two groups.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">These findings suggest that a blunted adrenocortical response to stress may represent a common feature of chronic allergic inflammatory processes that may be relevant in different forms of chronic manifestation of atopy.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Buske-Kirschbaum</LastName><ForeName>Angelika</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Psychobiology, Center for Psychobiological and Psychosomatic Research, University of Trier, Trier, Germany. buske@uni-trier.de</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>von Auer</LastName><ForeName>Kristin</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Krieger</LastName><ForeName>Silke</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Weis</LastName><ForeName>Stefan</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Rauh</LastName><ForeName>Wolfgang</ForeName><Initials>W</Initials></Author><Author ValidYN="Y"><LastName>Hellhammer</LastName><ForeName>Dirk</ForeName><Initials>D</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Psychosom Med</MedlineTA><NlmUniqueID>0376505</NlmUniqueID><ISSNLinking>0033-3174</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>WI4X0X7BPJ</RegistryNumber><NameOfSubstance UI="D006854">Hydrocortisone</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000302" MajorTopicYN="N">Adrenal Cortex</DescriptorName><QualifierName UI="Q000557" MajorTopicYN="Y">secretion</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001249" MajorTopicYN="N">Asthma</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName><QualifierName UI="Q000523" MajorTopicYN="N">psychology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002940" MajorTopicYN="N">Circadian Rhythm</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006339" MajorTopicYN="N">Heart Rate</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006854" MajorTopicYN="N">Hydrocortisone</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName><QualifierName UI="Q000557" MajorTopicYN="Y">secretion</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006969" MajorTopicYN="N">Hypersensitivity, Immediate</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName><QualifierName UI="Q000523" MajorTopicYN="N">psychology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007030" MajorTopicYN="N">Hypothalamo-Hypophyseal System</DescriptorName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010913" MajorTopicYN="N">Pituitary-Adrenal System</DescriptorName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012463" MajorTopicYN="N">Saliva</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013315" MajorTopicYN="N">Stress, Psychological</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011795" MajorTopicYN="N">Surveys and Questionnaires</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2003</Year><Month>9</Month><Day>26</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate 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