Real-time detection of p-phenylenediamine penetration into human skin by in vivo Raman spectroscopy.
Identifieur interne : 000104 ( Main/Exploration ); précédent : 000103; suivant : 000105Real-time detection of p-phenylenediamine penetration into human skin by in vivo Raman spectroscopy.
Auteurs : Laura Marjolijn Pot [Pays-Bas] ; Pieter-Jan Coenraads [Pays-Bas] ; Brunhilde Blömeke [Allemagne] ; Gerwin J. Puppels [Pays-Bas] ; Peter J. Caspers [Pays-Bas]Source :
- Contact dermatitis [ 1600-0536 ] ; 2016.
English descriptors
- KwdEn :
- Acetylation, Adult, Coloring Agents (administration & dosage), Coloring Agents (metabolism), Coloring Agents (pharmacokinetics), Female, Half-Life, Humans, Male, Phenylenediamines (administration & dosage), Phenylenediamines (metabolism), Phenylenediamines (pharmacokinetics), Skin (chemistry), Skin (metabolism), Skin Absorption, Spectrum Analysis, Raman.
- MESH :
- chemical , administration & dosage : Coloring Agents, Phenylenediamines.
- chemical , metabolism : Coloring Agents, Phenylenediamines.
- chemical , pharmacokinetics : Coloring Agents, Phenylenediamines.
- chemistry : Skin.
- metabolism : Skin.
- Acetylation, Adult, Female, Half-Life, Humans, Male, Skin Absorption, Spectrum Analysis, Raman.
Abstract
Penetration, autoxidation and N-acetylation of p-phenylenediamine (PPD) have been studied in vitro and ex vivo. However, a clear understanding of in vivo PPD penetration and the formation of PPD derivatives is lacking.
DOI: 10.1111/cod.12523
PubMed: 26778536
Affiliations:
- Allemagne, Pays-Bas
- Groningue (province), Hollande-Méridionale, Rhénanie-Palatinat
- Groningue, Rotterdam, Trèves (Allemagne)
- Université de Trèves
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Le document en format XML
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<series><title level="j">Contact dermatitis</title>
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<term>Coloring Agents (metabolism)</term>
<term>Coloring Agents (pharmacokinetics)</term>
<term>Female</term>
<term>Half-Life</term>
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<term>Male</term>
<term>Phenylenediamines (administration & dosage)</term>
<term>Phenylenediamines (metabolism)</term>
<term>Phenylenediamines (pharmacokinetics)</term>
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<term>Skin (metabolism)</term>
<term>Skin Absorption</term>
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<term>Phenylenediamines</term>
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<term>Phenylenediamines</term>
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<term>Phenylenediamines</term>
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<front><div type="abstract" xml:lang="en">Penetration, autoxidation and N-acetylation of p-phenylenediamine (PPD) have been studied in vitro and ex vivo. However, a clear understanding of in vivo PPD penetration and the formation of PPD derivatives is lacking.</div>
</front>
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<li>Pays-Bas</li>
</country>
<region><li>Groningue (province)</li>
<li>Hollande-Méridionale</li>
<li>Rhénanie-Palatinat</li>
</region>
<settlement><li>Groningue</li>
<li>Rotterdam</li>
<li>Trèves (Allemagne)</li>
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<orgName><li>Université de Trèves</li>
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<tree><country name="Pays-Bas"><region name="Groningue (province)"><name sortKey="Pot, Laura Marjolijn" sort="Pot, Laura Marjolijn" uniqKey="Pot L" first="Laura Marjolijn" last="Pot">Laura Marjolijn Pot</name>
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<name sortKey="Caspers, Peter J" sort="Caspers, Peter J" uniqKey="Caspers P" first="Peter J" last="Caspers">Peter J. Caspers</name>
<name sortKey="Coenraads, Pieter Jan" sort="Coenraads, Pieter Jan" uniqKey="Coenraads P" first="Pieter-Jan" last="Coenraads">Pieter-Jan Coenraads</name>
<name sortKey="Puppels, Gerwin J" sort="Puppels, Gerwin J" uniqKey="Puppels G" first="Gerwin J" last="Puppels">Gerwin J. Puppels</name>
</country>
<country name="Allemagne"><region name="Rhénanie-Palatinat"><name sortKey="Blomeke, Brunhilde" sort="Blomeke, Brunhilde" uniqKey="Blomeke B" first="Brunhilde" last="Blömeke">Brunhilde Blömeke</name>
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