Real-time detection of p-phenylenediamine penetration into human skin by in vivo Raman spectroscopy.
Identifieur interne : 000161 ( PubMed/Curation ); précédent : 000160; suivant : 000162Real-time detection of p-phenylenediamine penetration into human skin by in vivo Raman spectroscopy.
Auteurs : Laura Marjolijn Pot [Pays-Bas] ; Pieter-Jan Coenraads [Pays-Bas] ; Brunhilde Blömeke [Allemagne] ; Gerwin J. Puppels [Pays-Bas] ; Peter J. Caspers [Pays-Bas]Source :
- Contact dermatitis [ 1600-0536 ] ; 2016.
English descriptors
- KwdEn :
- Acetylation, Adult, Coloring Agents (administration & dosage), Coloring Agents (metabolism), Coloring Agents (pharmacokinetics), Female, Half-Life, Humans, Male, Phenylenediamines (administration & dosage), Phenylenediamines (metabolism), Phenylenediamines (pharmacokinetics), Skin (chemistry), Skin (metabolism), Skin Absorption, Spectrum Analysis, Raman.
- MESH :
- chemical , administration & dosage : Coloring Agents, Phenylenediamines.
- chemical , metabolism : Coloring Agents, Phenylenediamines.
- chemical , pharmacokinetics : Coloring Agents, Phenylenediamines.
- chemistry : Skin.
- metabolism : Skin.
- Acetylation, Adult, Female, Half-Life, Humans, Male, Skin Absorption, Spectrum Analysis, Raman.
Abstract
Penetration, autoxidation and N-acetylation of p-phenylenediamine (PPD) have been studied in vitro and ex vivo. However, a clear understanding of in vivo PPD penetration and the formation of PPD derivatives is lacking.
DOI: 10.1111/cod.12523
PubMed: 26778536
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Puppels</name><affiliation wicri:level="1"><nlm:affiliation>Department of Dermatology, Centre for Optical Diagnostics and Therapy, Erasmus MC, 3015, CE, Rotterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Dermatology, Centre for Optical Diagnostics and Therapy, Erasmus MC, 3015, CE, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Caspers, Peter J" sort="Caspers, Peter J" uniqKey="Caspers P" first="Peter J" last="Caspers">Peter J. Caspers</name><affiliation wicri:level="1"><nlm:affiliation>Department of Dermatology, Centre for Optical Diagnostics and Therapy, Erasmus MC, 3015, CE, Rotterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Dermatology, Centre for Optical Diagnostics and Therapy, Erasmus MC, 3015, CE, Rotterdam</wicri:regionArea></affiliation></author></analytic><series><title level="j">Contact dermatitis</title><idno type="eISSN">1600-0536</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acetylation</term><term>Adult</term><term>Coloring Agents (administration & dosage)</term><term>Coloring Agents (metabolism)</term><term>Coloring Agents (pharmacokinetics)</term><term>Female</term><term>Half-Life</term><term>Humans</term><term>Male</term><term>Phenylenediamines (administration & dosage)</term><term>Phenylenediamines (metabolism)</term><term>Phenylenediamines (pharmacokinetics)</term><term>Skin (chemistry)</term><term>Skin (metabolism)</term><term>Skin Absorption</term><term>Spectrum Analysis, Raman</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Coloring Agents</term><term>Phenylenediamines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Coloring Agents</term><term>Phenylenediamines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacokinetics" xml:lang="en"><term>Coloring Agents</term><term>Phenylenediamines</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Skin</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Skin</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Acetylation</term><term>Adult</term><term>Female</term><term>Half-Life</term><term>Humans</term><term>Male</term><term>Skin Absorption</term><term>Spectrum Analysis, Raman</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Penetration, autoxidation and N-acetylation of p-phenylenediamine (PPD) have been studied in vitro and ex vivo. However, a clear understanding of in vivo PPD penetration and the formation of PPD derivatives is lacking.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26778536</PMID><DateCreated><Year>2016</Year><Month>02</Month><Day>22</Day></DateCreated><DateCompleted><Year>2016</Year><Month>12</Month><Day>13</Day></DateCompleted><DateRevised><Year>2016</Year><Month>12</Month><Day>30</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1600-0536</ISSN><JournalIssue CitedMedium="Internet"><Volume>74</Volume><Issue>3</Issue><PubDate><Year>2016</Year><Month>Mar</Month></PubDate></JournalIssue><Title>Contact dermatitis</Title><ISOAbbreviation>Contact Derm.</ISOAbbreviation></Journal><ArticleTitle>Real-time detection of p-phenylenediamine penetration into human skin by in vivo Raman spectroscopy.</ArticleTitle><Pagination><MedlinePgn>152-8</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/cod.12523</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Penetration, autoxidation and N-acetylation of p-phenylenediamine (PPD) have been studied in vitro and ex vivo. However, a clear understanding of in vivo PPD penetration and the formation of PPD derivatives is lacking.</AbstractText><AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">To obtain insights into the in vivo penetration, clearance and formation of PPD derivatives in human skin.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Patch test chambers containing PPD 1% pet. were applied to the forearms of two human volunteers, with increasing application times. Non-invasive Raman microspectroscopy was used for detection of PPD (derivatives) in skin at several follow-up times.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Application of a PPD 1% pet. patch for 30 min resulted in substantial amounts of PPD in the stratum corneum of 90 mg PPD/g keratin. PPD contents were highest after three applications for 1 h each (330 mg PPD/g keratin), followed by single applications for 2 h 40 min, 2 h, and 23 h. The PPD half-time in the skin was 3 h. No spectral contributions of Bandrowski's base, monoacetyl-PPD and diacetyl-PPD were detected.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">We have gained insights into the in vivo penetration of PPD in human skin by using non-invasive Raman spectroscopy. Penetration into the skin was fast, and the PPD concentrations detected in the stratum corneum were high. PPD was detected in both the stratum corneum and the viable epidermis. Oxidized or acetylated PPD derivatives could not be detected.</AbstractText><CopyrightInformation>© 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Pot</LastName><ForeName>Laura Marjolijn</ForeName><Initials>LM</Initials><AffiliationInfo><Affiliation>Department of Dermatology, University Medical Centre Groningen, University of Groningen, 9700, RB, Groningen, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Coenraads</LastName><ForeName>Pieter-Jan</ForeName><Initials>PJ</Initials><AffiliationInfo><Affiliation>Department of Dermatology, University Medical Centre Groningen, University of Groningen, 9700, RB, Groningen, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Blömeke</LastName><ForeName>Brunhilde</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of Environmental Toxicology, University of Trier, D-54296, Trier, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Puppels</LastName><ForeName>Gerwin J</ForeName><Initials>GJ</Initials><AffiliationInfo><Affiliation>Department of Dermatology, Centre for Optical Diagnostics and Therapy, Erasmus MC, 3015, CE, Rotterdam, The Netherlands.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>RiverD International B.V., 3029, AK, Rotterdam, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Caspers</LastName><ForeName>Peter J</ForeName><Initials>PJ</Initials><AffiliationInfo><Affiliation>Department of Dermatology, Centre for Optical Diagnostics and Therapy, Erasmus MC, 3015, CE, Rotterdam, The Netherlands.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>RiverD International B.V., 3029, AK, Rotterdam, The Netherlands.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>01</Month><Day>18</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Contact Dermatitis</MedlineTA><NlmUniqueID>7604950</NlmUniqueID><ISSNLinking>0105-1873</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D004396">Coloring Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010655">Phenylenediamines</NameOfSubstance></Chemical><Chemical><RegistryNumber>U770QIT64J</RegistryNumber><NameOfSubstance UI="C029728">4-phenylenediamine</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000107" MajorTopicYN="N">Acetylation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004396" MajorTopicYN="N">Coloring Agents</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName><QualifierName UI="Q000493" MajorTopicYN="Y">pharmacokinetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006207" MajorTopicYN="N">Half-Life</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010655" MajorTopicYN="N">Phenylenediamines</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName><QualifierName UI="Q000493" MajorTopicYN="Y">pharmacokinetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012867" MajorTopicYN="N">Skin</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012869" MajorTopicYN="Y">Skin Absorption</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013059" MajorTopicYN="N">Spectrum Analysis, Raman</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Raman spectroscopy</Keyword><Keyword MajorTopicYN="N">in vivo</Keyword><Keyword MajorTopicYN="N">p-phenylenediamine (PPD)</Keyword><Keyword MajorTopicYN="N">penetration</Keyword><Keyword MajorTopicYN="N">skin</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>05</Month><Day>06</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2015</Year><Month>10</Month><Day>25</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2015</Year><Month>09</Month><Day>24</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>1</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>1</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>12</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">26778536</ArticleId><ArticleId IdType="doi">10.1111/cod.12523</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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