LeHavreV1, PubMed, Checkpoint, bibRecord, 000344

[Methemoglobinemia induced by repeated abuse of lidocaine viscous gel].

Identifieur interne : 000344 ( PubMed/Checkpoint ); précédent : 000343; suivant : 000345

[Methemoglobinemia induced by repeated abuse of lidocaine viscous gel].

Auteurs : C. Lacroix [France] ; M. Peureux ; M. Borel ; J. Goulle

Source :

Acta clinica Belgica [ 1784-3286 ] ; 2002.

RBID : pubmed:11974447

English descriptors

KwdEn :
- Adult, Anesthetics, Local (administration & dosage), Anesthetics, Local (adverse effects), Humans, Lidocaine (administration & dosage), Lidocaine (adverse effects), Male, Methemoglobinemia (chemically induced), Substance-Related Disorders.
MESH :
- chemical , administration & dosage : Anesthetics, Local, Lidocaine.
- chemical , adverse effects : Anesthetics, Local, Lidocaine.
- chemically induced : Methemoglobinemia.
- Adult, Humans, Male, Substance-Related Disorders.

Abstract

Lidocaine use may lead to methemoglobinemia. Lidocaine is clinically widely used as an anaesthesic drug, however its toxic effect is rare. We report a high methemoglobinemia level of 31.1% following repeated Xylocaine gel oral applications. New metabolic pathways of lidocaine have been reported leading to dimethylphenylhydroxylamine in humans. This metabolism is very similar to the aniline derivative ones, and may explain lidocaine methemoglobinemia effect.

PubMed: 11974447

Affiliations:

France

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pubmed:11974447

Le document en format XML

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<author><name sortKey="Lacroix, C" sort="Lacroix, C" uniqKey="Lacroix C" first="C" last="Lacroix">C. Lacroix</name>
<affiliation wicri:level="1"><nlm:affiliation>Laboratoire de Pharmacocinétique et de Toxicologie Clinique-Groupe Hospitalier B.P. 24-76083 Le Havre, France. clacroix@ch-havre.fr</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratoire de Pharmacocinétique et de Toxicologie Clinique-Groupe Hospitalier B.P. 24-76083 Le Havre</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Peureux, M" sort="Peureux, M" uniqKey="Peureux M" first="M" last="Peureux">M. Peureux</name>
</author>
<author><name sortKey="Borel, M" sort="Borel, M" uniqKey="Borel M" first="M" last="Borel">M. Borel</name>
</author>
<author><name sortKey="Goulle, J" sort="Goulle, J" uniqKey="Goulle J" first="J" last="Goulle">J. Goulle</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">[Methemoglobinemia induced by repeated abuse of lidocaine viscous gel].</title>
<author><name sortKey="Lacroix, C" sort="Lacroix, C" uniqKey="Lacroix C" first="C" last="Lacroix">C. Lacroix</name>
<affiliation wicri:level="1"><nlm:affiliation>Laboratoire de Pharmacocinétique et de Toxicologie Clinique-Groupe Hospitalier B.P. 24-76083 Le Havre, France. clacroix@ch-havre.fr</nlm:affiliation>
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<author><name sortKey="Peureux, M" sort="Peureux, M" uniqKey="Peureux M" first="M" last="Peureux">M. Peureux</name>
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<author><name sortKey="Borel, M" sort="Borel, M" uniqKey="Borel M" first="M" last="Borel">M. Borel</name>
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<author><name sortKey="Goulle, J" sort="Goulle, J" uniqKey="Goulle J" first="J" last="Goulle">J. Goulle</name>
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<series><title level="j">Acta clinica Belgica</title>
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<term>Humans</term>
<term>Lidocaine (administration & dosage)</term>
<term>Lidocaine (adverse effects)</term>
<term>Male</term>
<term>Methemoglobinemia (chemically induced)</term>
<term>Substance-Related Disorders</term>
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<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Anesthetics, Local</term>
<term>Lidocaine</term>
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<keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Anesthetics, Local</term>
<term>Lidocaine</term>
</keywords>
<keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Methemoglobinemia</term>
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<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
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<term>Male</term>
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<front><div type="abstract" xml:lang="en">Lidocaine use may lead to methemoglobinemia. Lidocaine is clinically widely used as an anaesthesic drug, however its toxic effect is rare. We report a high methemoglobinemia level of 31.1% following repeated Xylocaine gel oral applications. New metabolic pathways of lidocaine have been reported leading to dimethylphenylhydroxylamine in humans. This metabolism is very similar to the aniline derivative ones, and may explain lidocaine methemoglobinemia effect.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">11974447</PMID>
<DateCreated><Year>2002</Year>
<Month>4</Month>
<Day>26</Day>
</DateCreated>
<DateCompleted><Year>2002</Year>
<Month>06</Month>
<Day>19</Day>
</DateCompleted>
<DateRevised><Year>2016</Year>
<Month>3</Month>
<Day>14</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Print">1784-3286</ISSN>
<JournalIssue CitedMedium="Print"><Volume>57 Suppl 1</Volume>
<PubDate><Year>2002</Year>
</PubDate>
</JournalIssue>
<Title>Acta clinica Belgica</Title>
<ISOAbbreviation>Acta Clin Belg</ISOAbbreviation>
</Journal>
<ArticleTitle>[Methemoglobinemia induced by repeated abuse of lidocaine viscous gel].</ArticleTitle>
<Pagination><MedlinePgn>58-62</MedlinePgn>
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<Abstract><AbstractText>Lidocaine use may lead to methemoglobinemia. Lidocaine is clinically widely used as an anaesthesic drug, however its toxic effect is rare. We report a high methemoglobinemia level of 31.1% following repeated Xylocaine gel oral applications. New metabolic pathways of lidocaine have been reported leading to dimethylphenylhydroxylamine in humans. This metabolism is very similar to the aniline derivative ones, and may explain lidocaine methemoglobinemia effect.</AbstractText>
</Abstract>
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<Initials>C</Initials>
<AffiliationInfo><Affiliation>Laboratoire de Pharmacocinétique et de Toxicologie Clinique-Groupe Hospitalier B.P. 24-76083 Le Havre, France. clacroix@ch-havre.fr</Affiliation>
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<Author ValidYN="Y"><LastName>Borel</LastName>
<ForeName>M</ForeName>
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<Author ValidYN="Y"><LastName>Goulle</LastName>
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<VernacularTitle>Methemoglobinemie consecutive a l'abus de gel de Lidocaïne visqueuse.</VernacularTitle>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>Acta Clin Belg</MedlineTA>
<NlmUniqueID>0370306</NlmUniqueID>
<ISSNLinking>1784-3286</ISSNLinking>
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<QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
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<MeshHeading><DescriptorName UI="D008012" MajorTopicYN="N">Lidocaine</DescriptorName>
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<QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008708" MajorTopicYN="N">Methemoglobinemia</DescriptorName>
<QualifierName UI="Q000139" MajorTopicYN="Y">chemically induced</QualifierName>
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<MeshHeading><DescriptorName UI="D019966" MajorTopicYN="N">Substance-Related Disorders</DescriptorName>
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<PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2002</Year>
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<Day>27</Day>
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<affiliations><list><country><li>France</li>
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<tree><noCountry><name sortKey="Borel, M" sort="Borel, M" uniqKey="Borel M" first="M" last="Borel">M. Borel</name>
<name sortKey="Goulle, J" sort="Goulle, J" uniqKey="Goulle J" first="J" last="Goulle">J. Goulle</name>
<name sortKey="Peureux, M" sort="Peureux, M" uniqKey="Peureux M" first="M" last="Peureux">M. Peureux</name>
</noCountry>
<country name="France"><noRegion><name sortKey="Lacroix, C" sort="Lacroix, C" uniqKey="Lacroix C" first="C" last="Lacroix">C. Lacroix</name>
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[Methemoglobinemia induced by repeated abuse of lidocaine viscous gel].

[Methemoglobinemia induced by repeated abuse of lidocaine viscous gel].

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki