Expression of RAS-like family members, c-jun and c-myc mRNA levels in neoplastic hemocytes of soft-shell clams Mya arenaria using microsphere-based 8-plex branched DNA assay
Identifieur interne : 000383 ( Ncbi/Checkpoint ); précédent : 000382; suivant : 000384Expression of RAS-like family members, c-jun and c-myc mRNA levels in neoplastic hemocytes of soft-shell clams Mya arenaria using microsphere-based 8-plex branched DNA assay
Auteurs : A. Siah [Canada] ; P. Mckenna [Canada] ; J. M. Danger [France] ; G. Johnson [Canada] ; F. C. J. Berthe [Italie]Source :
- Results in Immunology [ 2211-2839 ] ; 2012.
Abstract
The molecular mechanisms by which disseminated neoplasia (DN) is developed in soft shell clams
Url:
DOI: 10.1016/j.rinim.2012.03.003
PubMed: 24371570
PubMed Central: 3862338
Affiliations:
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<affiliation wicri:level="1"><nlm:aff id="aff2">Department of Pathology & Microbiology, Atlantic Veterinary College, University of Prince Edward Island, 220 University Avenue, Charlottetown, PEI, Canada C1A 4P3</nlm:aff>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Expression of RAS-like family members, c-jun and c-myc mRNA levels in neoplastic hemocytes of soft-shell clams <italic>Mya arenaria</italic>
using microsphere-based 8-plex branched DNA assay</title>
<author><name sortKey="Siah, A" sort="Siah, A" uniqKey="Siah A" first="A." last="Siah">A. Siah</name>
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<series><title level="j">Results in Immunology</title>
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<front><div type="abstract" xml:lang="en"><p>The molecular mechanisms by which disseminated neoplasia (DN) is developed in soft shell clams <italic>Mya arenaria</italic>
remain largely unknown. This study aims at quantifying Rho-like GTPase, RAS-Rho, RAS-related C3 botulinum (RAS C3), c-jun as well as c-myc transcript levels in clams sampled at North River (Charlottetown, Prince Edward Island, Canada). The transcripts were quantified using multiplex gene analysis (Quantigene<sup>®</sup>
2 Plex, Affymetrix) in 3 groups of clams: (1) Group C (healthy clams considered as control) with a low percentage of tetraploid hemocytes (<10%); (2) Group D (disease in development): individuals presenting a percentage of tetraploid cells ranging between 10% and 50%; (3) Group E (established disease): clams with a high percentage of tetraploid hemocytes (>50%). Data showed a down-regulation of Rho-like GTPase, Rho-like subfamily, RAS C3, c-jun and an up-regulation of c-myc gene expression. It is believed that a deregulation of the expression of these genes could partly unravel the molecular mechanisms involved in the development of DN in soft shell clams <italic>Mya arenaria</italic>
. Further investigations should be pursued to determine the role of these gene products in clams' hemocytes.</p>
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