LeHavreV1, Ncbi, Checkpoint, bibRecord, 000238

Lymphoma in patients treated with anti-TNF: results of the 3-year prospective French RATIO registry

Identifieur interne : 000238 ( Ncbi/Checkpoint ); précédent : 000237; suivant : 000239

Lymphoma in patients treated with anti-TNF: results of the 3-year prospective French RATIO registry

Auteurs : Xavier Mariette ; Florence Tubach ; Haleh Bagheri ; Michel Bardet ; Jean-Marie Berthelot ; Philippe Gaudin ; Denis Heresbach ; Antoine Martin ; Thierry Schaeverbeke ; Dominique Salmon ; Marc Lemann ; Olivier Hermine ; Martine Raphael ; Philippe Ravaud

Source :

Annals of the Rheumatic Diseases [ 0003-4967 ] ; 2009.

RBID : PMC:2925048

Abstract

Objective

To describe cases of lymphoma associated with anti-TNF therapy, identify risk factors, estimate the incidence and compare risks for different anti-TNF agents.

Methods

We designed a national prospective registry (RATIO) from 2004 to 2006, for collecting all cases of lymphoma in French patients receiving anti-TNF therapy, whatever the indication. We conducted a case-control analysis including two controls treated with anti-TNF per case and an incidence study of lymphoma with the French population used as reference..

Results

We collected 38 cases of lymphoma, 31 non-Hodgkin’s lymphoma (NHL) (26 B-cell and 5 T-cell), 5 Hodgkin’s lymphoma (HL) and 2 Hodgkin’s-like lymphoma. Epstein-Barr virus (EBV) was detected in 2 of 2 Hodgkin’s-like lymphoma, 3 of 5 HL and one NHL. Patients receiving adalimumab or infliximab had a higher risk than those treated with etanercept: SIR = 4.1 (2.3–7.1) and 3.6 (2.3–5.6) versus 0.9 (0.4– 1.8). The exposure to adalimumab or infliximab versus etanercept was an independent risk factor for lymphoma in the case-control study: odds ratio=4.7 (1.3– 17.7) and 4.1 (1.4–12.5), respectively. The sex and age- adjusted incidence rate of lymphoma was 42.1 per 100,000 patient-years. The standardized incidence ratio (SIR) was 2.4 (95% confidence interval [CI] 1.7–3.2).

Conclusion

Some lymphomas associated with immunosuppression may occur in patients receiving anti TNF therapy, and the risk of lymphoma is higher with monoclonal-antibody therapy than with soluble-receptor therapy.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2925048

DOI: 10.1136/ard.2009.117762
PubMed: 19828563
PubMed Central: 2925048

Affiliations:

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PMC:2925048

Le document en format XML

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<author><name sortKey="Gaudin, Philippe" sort="Gaudin, Philippe" uniqKey="Gaudin P" first="Philippe" last="Gaudin">Philippe Gaudin</name>
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<author><name sortKey="Heresbach, Denis" sort="Heresbach, Denis" uniqKey="Heresbach D" first="Denis" last="Heresbach">Denis Heresbach</name>
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<author><name sortKey="Martin, Antoine" sort="Martin, Antoine" uniqKey="Martin A" first="Antoine" last="Martin">Antoine Martin</name>
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<author><name sortKey="Schaeverbeke, Thierry" sort="Schaeverbeke, Thierry" uniqKey="Schaeverbeke T" first="Thierry" last="Schaeverbeke">Thierry Schaeverbeke</name>
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<author><name sortKey="Salmon, Dominique" sort="Salmon, Dominique" uniqKey="Salmon D" first="Dominique" last="Salmon">Dominique Salmon</name>
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<addr-line>27 rue du Faubourg Saint Antoine, 75679 Paris Cedex 14, France,FR</addr-line>
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<author><name sortKey="Hermine, Olivier" sort="Hermine, Olivier" uniqKey="Hermine O" first="Olivier" last="Hermine">Olivier Hermine</name>
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<author><name sortKey="Raphael, Martine" sort="Raphael, Martine" uniqKey="Raphael M" first="Martine" last="Raphael">Martine Raphael</name>
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<author><name sortKey="Ravaud, Philippe" sort="Ravaud, Philippe" uniqKey="Ravaud P" first="Philippe" last="Ravaud">Philippe Ravaud</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Lymphoma in patients treated with anti-TNF: results of the 3-year prospective French RATIO registry</title>
<author><name sortKey="Mariette, Xavier" sort="Mariette, Xavier" uniqKey="Mariette X" first="Xavier" last="Mariette">Xavier Mariette</name>
<affiliation><nlm:aff id="A1">Service de rhumatologie<institution>AP-HP</institution>
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<author><name sortKey="Tubach, Florence" sort="Tubach, Florence" uniqKey="Tubach F" first="Florence" last="Tubach">Florence Tubach</name>
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<author><name sortKey="Bagheri, Haleh" sort="Bagheri, Haleh" uniqKey="Bagheri H" first="Haleh" last="Bagheri">Haleh Bagheri</name>
<affiliation><nlm:aff id="A3">Unité de Pharmacoépidémiologie : Evaluation de l'exposition et du risque médicamenteux<institution>Université Paul Sabatier - Toulouse III : EA3696</institution>
<institution>CHU Toulouse</institution>
<addr-line>F-31000 Toulouse,FR</addr-line>
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<wicri:noCountry code="subfield">R</wicri:noCountry>
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</author>
<author><name sortKey="Bardet, Michel" sort="Bardet, Michel" uniqKey="Bardet M" first="Michel" last="Bardet">Michel Bardet</name>
<affiliation><nlm:aff id="A4">Service de médecine interne et rhumatologie<institution>Hôpital de la source</institution>
<institution>CHR Orléans</institution>
<addr-line>Orleans,FR</addr-line>
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<author><name sortKey="Berthelot, Jean Marie" sort="Berthelot, Jean Marie" uniqKey="Berthelot J" first="Jean-Marie" last="Berthelot">Jean-Marie Berthelot</name>
<affiliation><nlm:aff id="A5">Service de Rhumatologie<institution>CHU Nantes</institution>
<institution>Hôtel-Dieu</institution>
<addr-line>Nantes,FR</addr-line>
</nlm:aff>
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<author><name sortKey="Gaudin, Philippe" sort="Gaudin, Philippe" uniqKey="Gaudin P" first="Philippe" last="Gaudin">Philippe Gaudin</name>
<affiliation><nlm:aff id="A6">Service de Rhumatologie<institution>Hôpital Michallon</institution>
<institution>CHU Grenoble</institution>
<institution>Université Joseph Fourier - Grenoble I</institution>
<addr-line>Grenoble,FR</addr-line>
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<author><name sortKey="Heresbach, Denis" sort="Heresbach, Denis" uniqKey="Heresbach D" first="Denis" last="Heresbach">Denis Heresbach</name>
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<author><name sortKey="Martin, Antoine" sort="Martin, Antoine" uniqKey="Martin A" first="Antoine" last="Martin">Antoine Martin</name>
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<addr-line>St Brieuc,FR</addr-line>
</nlm:aff>
<wicri:noCountry code="subfield">R</wicri:noCountry>
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<author><name sortKey="Schaeverbeke, Thierry" sort="Schaeverbeke, Thierry" uniqKey="Schaeverbeke T" first="Thierry" last="Schaeverbeke">Thierry Schaeverbeke</name>
<affiliation><nlm:aff id="A9">Service de rhumatologie<institution>CHU Bordeaux</institution>
<addr-line>FR</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Salmon, Dominique" sort="Salmon, Dominique" uniqKey="Salmon D" first="Dominique" last="Salmon">Dominique Salmon</name>
<affiliation><nlm:aff id="A10">Service de médecine interne<institution>AP-HP</institution>
<institution>Hôpital Cochin</institution>
<institution>Université Paris Descartes</institution>
<addr-line>27 rue du Faubourg Saint Antoine, 75679 Paris Cedex 14, France,FR</addr-line>
</nlm:aff>
<wicri:noCountry code="subfield">R</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Lemann, Marc" sort="Lemann, Marc" uniqKey="Lemann M" first="Marc" last="Lemann">Marc Lemann</name>
<affiliation><nlm:aff id="A11">Service de gastro-entérologie<institution>AP-HP</institution>
<institution>Hôpital Saint-Louis</institution>
<addr-line>Paris, FR</addr-line>
</nlm:aff>
<wicri:noCountry code="subfield">FR</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Hermine, Olivier" sort="Hermine, Olivier" uniqKey="Hermine O" first="Olivier" last="Hermine">Olivier Hermine</name>
<affiliation><nlm:aff id="A12">Service d'hématologie biologique<institution>AP-HP</institution>
<institution>Hôpital Necker - Enfants Malades</institution>
<institution>Université Paris Descartes</institution>
<addr-line>Paris,FR</addr-line>
</nlm:aff>
<wicri:noCountry code="subfield">R</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Raphael, Martine" sort="Raphael, Martine" uniqKey="Raphael M" first="Martine" last="Raphael">Martine Raphael</name>
<affiliation><nlm:aff id="A13">Laboratoire d'Hématologie<institution>AP-HP</institution>
<institution>Université Paris Sud - Paris XI</institution>
<institution>Hôpital Bicêtre</institution>
<addr-line>FR</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ravaud, Philippe" sort="Ravaud, Philippe" uniqKey="Ravaud P" first="Philippe" last="Ravaud">Philippe Ravaud</name>
<affiliation><nlm:aff id="A2">Modèles et méthodes de l'évaluation thérapeutique des maladies chroniques<institution>INSERM : U738</institution>
<institution>Université Paris-Diderot - Paris VII</institution>
<addr-line>Faculté de médecine Paris 7 16, Rue Henri Huchard 75018 Paris,FR</addr-line>
</nlm:aff>
<wicri:noCountry code="subfield">R</wicri:noCountry>
</affiliation>
</author>
</analytic>
<series><title level="j">Annals of the Rheumatic Diseases</title>
<idno type="ISSN">0003-4967</idno>
<idno type="eISSN">1468-2060</idno>
<imprint><date when="2009">2009</date>
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<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Objective</title>
<p id="P1">To describe cases of lymphoma associated with anti-TNF therapy, identify risk factors, estimate the incidence and compare risks for different anti-TNF agents.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P2">We designed a national prospective registry (RATIO) from 2004 to 2006, for collecting all cases of lymphoma in French patients receiving anti-TNF therapy, whatever the indication. We conducted a case-control analysis including two controls treated with anti-TNF per case and an incidence study of lymphoma with the French population used as reference..</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">We collected 38 cases of lymphoma, 31 non-Hodgkin’s lymphoma (NHL) (26 B-cell and 5 T-cell), 5 Hodgkin’s lymphoma (HL) and 2 Hodgkin’s-like lymphoma. Epstein-Barr virus (EBV) was detected in 2 of 2 Hodgkin’s-like lymphoma, 3 of 5 HL and one NHL. Patients receiving adalimumab or infliximab had a higher risk than those treated with etanercept: SIR = 4.1 (2.3–7.1) and 3.6 (2.3–5.6) versus 0.9 (0.4– 1.8). The exposure to adalimumab or infliximab versus etanercept was an independent risk factor for lymphoma in the case-control study: odds ratio=4.7 (1.3– 17.7) and 4.1 (1.4–12.5), respectively. The sex and age- adjusted incidence rate of lymphoma was 42.1 per 100,000 patient-years. The standardized incidence ratio (SIR) was 2.4 (95% confidence interval [CI] 1.7–3.2).</p>
</sec>
<sec id="S4"><title>Conclusion</title>
<p id="P4">Some lymphomas associated with immunosuppression may occur in patients receiving anti TNF therapy, and the risk of lymphoma is higher with monoclonal-antibody therapy than with soluble-receptor therapy.</p>
</sec>
</div>
</front>
</TEI>
<affiliations><list></list>
<tree><noCountry><name sortKey="Bagheri, Haleh" sort="Bagheri, Haleh" uniqKey="Bagheri H" first="Haleh" last="Bagheri">Haleh Bagheri</name>
<name sortKey="Bardet, Michel" sort="Bardet, Michel" uniqKey="Bardet M" first="Michel" last="Bardet">Michel Bardet</name>
<name sortKey="Berthelot, Jean Marie" sort="Berthelot, Jean Marie" uniqKey="Berthelot J" first="Jean-Marie" last="Berthelot">Jean-Marie Berthelot</name>
<name sortKey="Gaudin, Philippe" sort="Gaudin, Philippe" uniqKey="Gaudin P" first="Philippe" last="Gaudin">Philippe Gaudin</name>
<name sortKey="Heresbach, Denis" sort="Heresbach, Denis" uniqKey="Heresbach D" first="Denis" last="Heresbach">Denis Heresbach</name>
<name sortKey="Hermine, Olivier" sort="Hermine, Olivier" uniqKey="Hermine O" first="Olivier" last="Hermine">Olivier Hermine</name>
<name sortKey="Lemann, Marc" sort="Lemann, Marc" uniqKey="Lemann M" first="Marc" last="Lemann">Marc Lemann</name>
<name sortKey="Mariette, Xavier" sort="Mariette, Xavier" uniqKey="Mariette X" first="Xavier" last="Mariette">Xavier Mariette</name>
<name sortKey="Martin, Antoine" sort="Martin, Antoine" uniqKey="Martin A" first="Antoine" last="Martin">Antoine Martin</name>
<name sortKey="Raphael, Martine" sort="Raphael, Martine" uniqKey="Raphael M" first="Martine" last="Raphael">Martine Raphael</name>
<name sortKey="Ravaud, Philippe" sort="Ravaud, Philippe" uniqKey="Ravaud P" first="Philippe" last="Ravaud">Philippe Ravaud</name>
<name sortKey="Salmon, Dominique" sort="Salmon, Dominique" uniqKey="Salmon D" first="Dominique" last="Salmon">Dominique Salmon</name>
<name sortKey="Schaeverbeke, Thierry" sort="Schaeverbeke, Thierry" uniqKey="Schaeverbeke T" first="Thierry" last="Schaeverbeke">Thierry Schaeverbeke</name>
<name sortKey="Tubach, Florence" sort="Tubach, Florence" uniqKey="Tubach F" first="Florence" last="Tubach">Florence Tubach</name>
</noCountry>
</tree>
</affiliations>
</record>

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Lymphoma in patients treated with anti-TNF: results of the 3-year prospective French RATIO registry

Lymphoma in patients treated with anti-TNF: results of the 3-year prospective French RATIO registry

Source :

Abstract

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