Lymphoma in patients treated with anti-TNF: results of the 3-year prospective French RATIO registry
Identifieur interne : 000115 ( Pmc/Checkpoint ); précédent : 000114; suivant : 000116Lymphoma in patients treated with anti-TNF: results of the 3-year prospective French RATIO registry
Auteurs : Xavier Mariette ; Florence Tubach ; Haleh Bagheri ; Michel Bardet ; Jean-Marie Berthelot ; Philippe Gaudin ; Denis Heresbach ; Antoine Martin ; Thierry Schaeverbeke ; Dominique Salmon ; Marc Lemann ; Olivier Hermine ; Martine Raphael ; Philippe RavaudSource :
- Annals of the Rheumatic Diseases [ 0003-4967 ] ; 2009.
Abstract
To describe cases of lymphoma associated with anti-TNF therapy, identify risk factors, estimate the incidence and compare risks for different anti-TNF agents.
We designed a national prospective registry (RATIO) from 2004 to 2006, for collecting all cases of lymphoma in French patients receiving anti-TNF therapy, whatever the indication. We conducted a case-control analysis including two controls treated with anti-TNF per case and an incidence study of lymphoma with the French population used as reference..
We collected 38 cases of lymphoma, 31 non-Hodgkin’s lymphoma (NHL) (26 B-cell and 5 T-cell), 5 Hodgkin’s lymphoma (HL) and 2 Hodgkin’s-like lymphoma. Epstein-Barr virus (EBV) was detected in 2 of 2 Hodgkin’s-like lymphoma, 3 of 5 HL and one NHL. Patients receiving adalimumab or infliximab had a higher risk than those treated with etanercept: SIR = 4.1 (2.3–7.1) and 3.6 (2.3–5.6) versus 0.9 (0.4– 1.8). The exposure to adalimumab or infliximab versus etanercept was an independent risk factor for lymphoma in the case-control study: odds ratio=4.7 (1.3– 17.7) and 4.1 (1.4–12.5), respectively. The sex and age- adjusted incidence rate of lymphoma was 42.1 per 100,000 patient-years. The standardized incidence ratio (SIR) was 2.4 (95% confidence interval [CI] 1.7–3.2).
Some lymphomas associated with immunosuppression may occur in patients receiving anti TNF therapy, and the risk of lymphoma is higher with monoclonal-antibody therapy than with soluble-receptor therapy.
Url:
DOI: 10.1136/ard.2009.117762
PubMed: 19828563
PubMed Central: 2925048
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
PMC:2925048Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Lymphoma in patients treated with anti-TNF: results of the 3-year prospective French RATIO registry</title><author><name sortKey="Mariette, Xavier" sort="Mariette, Xavier" uniqKey="Mariette X" first="Xavier" last="Mariette">Xavier Mariette</name><affiliation><nlm:aff id="A1">Service de rhumatologie<institution>AP-HP</institution><institution>Hôpital Bicêtre</institution><institution>Université Paris Sud - Paris XI</institution><addr-line>Le Kremlin-Bicêtre,FR</addr-line></nlm:aff><wicri:noCountry code="subfield">R</wicri:noCountry></affiliation></author><author><name sortKey="Tubach, Florence" sort="Tubach, Florence" uniqKey="Tubach F" first="Florence" last="Tubach">Florence Tubach</name><affiliation><nlm:aff id="A2">Modèles et méthodes de l'évaluation thérapeutique des maladies chroniques<institution>INSERM : U738</institution><institution>Université Paris-Diderot - Paris VII</institution><addr-line>Faculté de médecine Paris 7 16, Rue Henri Huchard 75018 Paris,FR</addr-line></nlm:aff><wicri:noCountry code="subfield">R</wicri:noCountry></affiliation></author><author><name sortKey="Bagheri, Haleh" sort="Bagheri, Haleh" uniqKey="Bagheri H" first="Haleh" last="Bagheri">Haleh Bagheri</name><affiliation><nlm:aff id="A3">Unité de Pharmacoépidémiologie : Evaluation de l'exposition et du risque médicamenteux<institution>Université Paul Sabatier - Toulouse III : EA3696</institution><institution>CHU Toulouse</institution><addr-line>F-31000 Toulouse,FR</addr-line></nlm:aff><wicri:noCountry code="subfield">R</wicri:noCountry></affiliation></author><author><name sortKey="Bardet, Michel" sort="Bardet, Michel" uniqKey="Bardet M" first="Michel" last="Bardet">Michel Bardet</name><affiliation><nlm:aff id="A4">Service de médecine interne et rhumatologie<institution>Hôpital de la source</institution><institution>CHR Orléans</institution><addr-line>Orleans,FR</addr-line></nlm:aff><wicri:noCountry code="subfield">R</wicri:noCountry></affiliation></author><author><name sortKey="Berthelot, Jean Marie" sort="Berthelot, Jean Marie" uniqKey="Berthelot J" first="Jean-Marie" last="Berthelot">Jean-Marie Berthelot</name><affiliation><nlm:aff id="A5">Service de Rhumatologie<institution>CHU Nantes</institution><institution>Hôtel-Dieu</institution><addr-line>Nantes,FR</addr-line></nlm:aff><wicri:noCountry code="subfield">R</wicri:noCountry></affiliation></author><author><name sortKey="Gaudin, Philippe" sort="Gaudin, Philippe" uniqKey="Gaudin P" first="Philippe" last="Gaudin">Philippe Gaudin</name><affiliation><nlm:aff id="A6">Service de Rhumatologie<institution>Hôpital Michallon</institution><institution>CHU Grenoble</institution><institution>Université Joseph Fourier - Grenoble I</institution><addr-line>Grenoble,FR</addr-line></nlm:aff><wicri:noCountry code="subfield">R</wicri:noCountry></affiliation></author><author><name sortKey="Heresbach, Denis" sort="Heresbach, Denis" uniqKey="Heresbach D" first="Denis" last="Heresbach">Denis Heresbach</name><affiliation><nlm:aff id="A7">Service de Gastroentérologie<institution>CHU Rennes</institution><institution>Hôpital Pontchaillou</institution><addr-line>2 Rue Henri le Guilloux 35033 Rennes,FR</addr-line></nlm:aff><wicri:noCountry code="subfield">R</wicri:noCountry></affiliation></author><author><name sortKey="Martin, Antoine" sort="Martin, Antoine" uniqKey="Martin A" first="Antoine" last="Martin">Antoine Martin</name><affiliation><nlm:aff id="A8">Service de Rhumatologie<institution>Hôpital de St Brieuc</institution><addr-line>St Brieuc,FR</addr-line></nlm:aff><wicri:noCountry code="subfield">R</wicri:noCountry></affiliation></author><author><name sortKey="Schaeverbeke, Thierry" sort="Schaeverbeke, Thierry" uniqKey="Schaeverbeke T" first="Thierry" last="Schaeverbeke">Thierry Schaeverbeke</name><affiliation><nlm:aff id="A9">Service de rhumatologie<institution>CHU Bordeaux</institution><addr-line>FR</addr-line></nlm:aff></affiliation></author><author><name sortKey="Salmon, Dominique" sort="Salmon, Dominique" uniqKey="Salmon D" first="Dominique" last="Salmon">Dominique Salmon</name><affiliation><nlm:aff id="A10">Service de médecine interne<institution>AP-HP</institution><institution>Hôpital Cochin</institution><institution>Université Paris Descartes</institution><addr-line>27 rue du Faubourg Saint Antoine, 75679 Paris Cedex 14, France,FR</addr-line></nlm:aff><wicri:noCountry code="subfield">R</wicri:noCountry></affiliation></author><author><name sortKey="Lemann, Marc" sort="Lemann, Marc" uniqKey="Lemann M" first="Marc" last="Lemann">Marc Lemann</name><affiliation><nlm:aff id="A11">Service de gastro-entérologie<institution>AP-HP</institution><institution>Hôpital Saint-Louis</institution><addr-line>Paris, FR</addr-line></nlm:aff><wicri:noCountry code="subfield">FR</wicri:noCountry></affiliation></author><author><name sortKey="Hermine, Olivier" sort="Hermine, Olivier" uniqKey="Hermine O" first="Olivier" last="Hermine">Olivier Hermine</name><affiliation><nlm:aff id="A12">Service d'hématologie biologique<institution>AP-HP</institution><institution>Hôpital Necker - Enfants Malades</institution><institution>Université Paris Descartes</institution><addr-line>Paris,FR</addr-line></nlm:aff><wicri:noCountry code="subfield">R</wicri:noCountry></affiliation></author><author><name sortKey="Raphael, Martine" sort="Raphael, Martine" uniqKey="Raphael M" first="Martine" last="Raphael">Martine Raphael</name><affiliation><nlm:aff id="A13">Laboratoire d'Hématologie<institution>AP-HP</institution><institution>Université Paris Sud - Paris XI</institution><institution>Hôpital Bicêtre</institution><addr-line>FR</addr-line></nlm:aff></affiliation></author><author><name sortKey="Ravaud, Philippe" sort="Ravaud, Philippe" uniqKey="Ravaud P" first="Philippe" last="Ravaud">Philippe Ravaud</name><affiliation><nlm:aff id="A2">Modèles et méthodes de l'évaluation thérapeutique des maladies chroniques<institution>INSERM : U738</institution><institution>Université Paris-Diderot - Paris VII</institution><addr-line>Faculté de médecine Paris 7 16, Rue Henri Huchard 75018 Paris,FR</addr-line></nlm:aff><wicri:noCountry code="subfield">R</wicri:noCountry></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">19828563</idno><idno type="pmc">2925048</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2925048</idno><idno type="RBID">PMC:2925048</idno><idno type="doi">10.1136/ard.2009.117762</idno><date when="2009">2009</date><idno type="wicri:Area/Pmc/Corpus">000200</idno><idno type="wicri:Area/Pmc/Curation">000198</idno><idno type="wicri:Area/Pmc/Checkpoint">000115</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Lymphoma in patients treated with anti-TNF: results of the 3-year prospective French RATIO registry</title><author><name sortKey="Mariette, Xavier" sort="Mariette, Xavier" uniqKey="Mariette X" first="Xavier" last="Mariette">Xavier Mariette</name><affiliation><nlm:aff id="A1">Service de rhumatologie<institution>AP-HP</institution><institution>Hôpital Bicêtre</institution><institution>Université Paris Sud - Paris XI</institution><addr-line>Le Kremlin-Bicêtre,FR</addr-line></nlm:aff><wicri:noCountry code="subfield">R</wicri:noCountry></affiliation></author><author><name sortKey="Tubach, Florence" sort="Tubach, Florence" uniqKey="Tubach F" first="Florence" last="Tubach">Florence Tubach</name><affiliation><nlm:aff id="A2">Modèles et méthodes de l'évaluation thérapeutique des maladies chroniques<institution>INSERM : U738</institution><institution>Université Paris-Diderot - Paris VII</institution><addr-line>Faculté de médecine Paris 7 16, Rue Henri Huchard 75018 Paris,FR</addr-line></nlm:aff><wicri:noCountry code="subfield">R</wicri:noCountry></affiliation></author><author><name sortKey="Bagheri, Haleh" sort="Bagheri, Haleh" uniqKey="Bagheri H" first="Haleh" last="Bagheri">Haleh Bagheri</name><affiliation><nlm:aff id="A3">Unité de Pharmacoépidémiologie : Evaluation de l'exposition et du risque médicamenteux<institution>Université Paul Sabatier - Toulouse III : EA3696</institution><institution>CHU Toulouse</institution><addr-line>F-31000 Toulouse,FR</addr-line></nlm:aff><wicri:noCountry code="subfield">R</wicri:noCountry></affiliation></author><author><name sortKey="Bardet, Michel" sort="Bardet, Michel" uniqKey="Bardet M" first="Michel" last="Bardet">Michel Bardet</name><affiliation><nlm:aff id="A4">Service de médecine interne et rhumatologie<institution>Hôpital de la source</institution><institution>CHR Orléans</institution><addr-line>Orleans,FR</addr-line></nlm:aff><wicri:noCountry code="subfield">R</wicri:noCountry></affiliation></author><author><name sortKey="Berthelot, Jean Marie" sort="Berthelot, Jean Marie" uniqKey="Berthelot J" first="Jean-Marie" last="Berthelot">Jean-Marie Berthelot</name><affiliation><nlm:aff id="A5">Service de Rhumatologie<institution>CHU Nantes</institution><institution>Hôtel-Dieu</institution><addr-line>Nantes,FR</addr-line></nlm:aff><wicri:noCountry code="subfield">R</wicri:noCountry></affiliation></author><author><name sortKey="Gaudin, Philippe" sort="Gaudin, Philippe" uniqKey="Gaudin P" first="Philippe" last="Gaudin">Philippe Gaudin</name><affiliation><nlm:aff id="A6">Service de Rhumatologie<institution>Hôpital Michallon</institution><institution>CHU Grenoble</institution><institution>Université Joseph Fourier - Grenoble I</institution><addr-line>Grenoble,FR</addr-line></nlm:aff><wicri:noCountry code="subfield">R</wicri:noCountry></affiliation></author><author><name sortKey="Heresbach, Denis" sort="Heresbach, Denis" uniqKey="Heresbach D" first="Denis" last="Heresbach">Denis Heresbach</name><affiliation><nlm:aff id="A7">Service de Gastroentérologie<institution>CHU Rennes</institution><institution>Hôpital Pontchaillou</institution><addr-line>2 Rue Henri le Guilloux 35033 Rennes,FR</addr-line></nlm:aff><wicri:noCountry code="subfield">R</wicri:noCountry></affiliation></author><author><name sortKey="Martin, Antoine" sort="Martin, Antoine" uniqKey="Martin A" first="Antoine" last="Martin">Antoine Martin</name><affiliation><nlm:aff id="A8">Service de Rhumatologie<institution>Hôpital de St Brieuc</institution><addr-line>St Brieuc,FR</addr-line></nlm:aff><wicri:noCountry code="subfield">R</wicri:noCountry></affiliation></author><author><name sortKey="Schaeverbeke, Thierry" sort="Schaeverbeke, Thierry" uniqKey="Schaeverbeke T" first="Thierry" last="Schaeverbeke">Thierry Schaeverbeke</name><affiliation><nlm:aff id="A9">Service de rhumatologie<institution>CHU Bordeaux</institution><addr-line>FR</addr-line></nlm:aff></affiliation></author><author><name sortKey="Salmon, Dominique" sort="Salmon, Dominique" uniqKey="Salmon D" first="Dominique" last="Salmon">Dominique Salmon</name><affiliation><nlm:aff id="A10">Service de médecine interne<institution>AP-HP</institution><institution>Hôpital Cochin</institution><institution>Université Paris Descartes</institution><addr-line>27 rue du Faubourg Saint Antoine, 75679 Paris Cedex 14, France,FR</addr-line></nlm:aff><wicri:noCountry code="subfield">R</wicri:noCountry></affiliation></author><author><name sortKey="Lemann, Marc" sort="Lemann, Marc" uniqKey="Lemann M" first="Marc" last="Lemann">Marc Lemann</name><affiliation><nlm:aff id="A11">Service de gastro-entérologie<institution>AP-HP</institution><institution>Hôpital Saint-Louis</institution><addr-line>Paris, FR</addr-line></nlm:aff><wicri:noCountry code="subfield">FR</wicri:noCountry></affiliation></author><author><name sortKey="Hermine, Olivier" sort="Hermine, Olivier" uniqKey="Hermine O" first="Olivier" last="Hermine">Olivier Hermine</name><affiliation><nlm:aff id="A12">Service d'hématologie biologique<institution>AP-HP</institution><institution>Hôpital Necker - Enfants Malades</institution><institution>Université Paris Descartes</institution><addr-line>Paris,FR</addr-line></nlm:aff><wicri:noCountry code="subfield">R</wicri:noCountry></affiliation></author><author><name sortKey="Raphael, Martine" sort="Raphael, Martine" uniqKey="Raphael M" first="Martine" last="Raphael">Martine Raphael</name><affiliation><nlm:aff id="A13">Laboratoire d'Hématologie<institution>AP-HP</institution><institution>Université Paris Sud - Paris XI</institution><institution>Hôpital Bicêtre</institution><addr-line>FR</addr-line></nlm:aff></affiliation></author><author><name sortKey="Ravaud, Philippe" sort="Ravaud, Philippe" uniqKey="Ravaud P" first="Philippe" last="Ravaud">Philippe Ravaud</name><affiliation><nlm:aff id="A2">Modèles et méthodes de l'évaluation thérapeutique des maladies chroniques<institution>INSERM : U738</institution><institution>Université Paris-Diderot - Paris VII</institution><addr-line>Faculté de médecine Paris 7 16, Rue Henri Huchard 75018 Paris,FR</addr-line></nlm:aff><wicri:noCountry code="subfield">R</wicri:noCountry></affiliation></author></analytic><series><title level="j">Annals of the Rheumatic Diseases</title><idno type="ISSN">0003-4967</idno><idno type="eISSN">1468-2060</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Objective</title><p id="P1">To describe cases of lymphoma associated with anti-TNF therapy, identify risk factors, estimate the incidence and compare risks for different anti-TNF agents.</p></sec><sec id="S2"><title>Methods</title><p id="P2">We designed a national prospective registry (RATIO) from 2004 to 2006, for collecting all cases of lymphoma in French patients receiving anti-TNF therapy, whatever the indication. We conducted a case-control analysis including two controls treated with anti-TNF per case and an incidence study of lymphoma with the French population used as reference..</p></sec><sec id="S3"><title>Results</title><p id="P3">We collected 38 cases of lymphoma, 31 non-Hodgkin’s lymphoma (NHL) (26 B-cell and 5 T-cell), 5 Hodgkin’s lymphoma (HL) and 2 Hodgkin’s-like lymphoma. Epstein-Barr virus (EBV) was detected in 2 of 2 Hodgkin’s-like lymphoma, 3 of 5 HL and one NHL. Patients receiving adalimumab or infliximab had a higher risk than those treated with etanercept: SIR = 4.1 (2.3–7.1) and 3.6 (2.3–5.6) versus 0.9 (0.4– 1.8). The exposure to adalimumab or infliximab versus etanercept was an independent risk factor for lymphoma in the case-control study: odds ratio=4.7 (1.3– 17.7) and 4.1 (1.4–12.5), respectively. The sex and age- adjusted incidence rate of lymphoma was 42.1 per 100,000 patient-years. The standardized incidence ratio (SIR) was 2.4 (95% confidence interval [CI] 1.7–3.2).</p></sec><sec id="S4"><title>Conclusion</title><p id="P4">Some lymphomas associated with immunosuppression may occur in patients receiving anti TNF therapy, and the risk of lymphoma is higher with monoclonal-antibody therapy than with soluble-receptor therapy.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Ann Rheum Dis</journal-id><journal-title-group><journal-title>Annals of the Rheumatic Diseases</journal-title></journal-title-group><issn pub-type="ppub">0003-4967</issn><issn pub-type="epub">1468-2060</issn><publisher><publisher-name>BMJ Group</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">19828563</article-id><article-id pub-id-type="pmc">2925048</article-id><article-id pub-id-type="manuscript">HALMS431509</article-id><article-id pub-id-type="doi">10.1136/ard.2009.117762</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject><subj-group subj-group-type="subrepository"><subject>INSERM Subrepository</subject></subj-group></subj-group></article-categories><title-group><article-title>Lymphoma in patients treated with anti-TNF: results of the 3-year prospective French RATIO registry</article-title><alt-title>Lymphoma complicating anti-TNF therapy</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Mariette</surname><given-names>Xavier</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref rid="FN1" ref-type="author-notes">*</xref><xref ref-type="author-notes" rid="FN2">#</xref></contrib><contrib contrib-type="author"><name><surname>Tubach</surname><given-names>Florence</given-names></name><xref ref-type="aff" rid="A2">2</xref><xref ref-type="author-notes" rid="FN2">#</xref></contrib><contrib contrib-type="author"><name><surname>Bagheri</surname><given-names>Haleh</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Bardet</surname><given-names>Michel</given-names></name><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Berthelot</surname><given-names>Jean-Marie</given-names></name><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Gaudin</surname><given-names>Philippe</given-names></name><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Heresbach</surname><given-names>Denis</given-names></name><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author"><name><surname>Martin</surname><given-names>Antoine</given-names></name><xref ref-type="aff" rid="A8">8</xref></contrib><contrib contrib-type="author"><name><surname>Schaeverbeke</surname><given-names>Thierry</given-names></name><xref ref-type="aff" rid="A9">9</xref></contrib><contrib contrib-type="author"><name><surname>Salmon</surname><given-names>Dominique</given-names></name><xref ref-type="aff" rid="A10">10</xref></contrib><contrib contrib-type="author"><name><surname>Lemann</surname><given-names>Marc</given-names></name><xref ref-type="aff" rid="A11">11</xref></contrib><contrib contrib-type="author"><name><surname>Hermine</surname><given-names>Olivier</given-names></name><xref ref-type="aff" rid="A12">12</xref></contrib><contrib contrib-type="author"><name><surname>Raphael</surname><given-names>Martine</given-names></name><xref ref-type="aff" rid="A13">13</xref></contrib><contrib contrib-type="author"><name><surname>Ravaud</surname><given-names>Philippe</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><on-behalf-of>for the RATIO group</on-behalf-of></contrib-group><aff id="A1"><label>1</label>Service de rhumatologie<institution>AP-HP</institution><institution>Hôpital Bicêtre</institution><institution>Université Paris Sud - Paris XI</institution><addr-line>Le Kremlin-Bicêtre,FR</addr-line></aff><aff id="A2"><label>2</label>Modèles et méthodes de l'évaluation thérapeutique des maladies chroniques<institution>INSERM : U738</institution><institution>Université Paris-Diderot - Paris VII</institution><addr-line>Faculté de médecine Paris 7 16, Rue Henri Huchard 75018 Paris,FR</addr-line></aff><aff id="A3"><label>3</label>Unité de Pharmacoépidémiologie : Evaluation de l'exposition et du risque médicamenteux<institution>Université Paul Sabatier - Toulouse III : EA3696</institution><institution>CHU Toulouse</institution><addr-line>F-31000 Toulouse,FR</addr-line></aff><aff id="A4"><label>4</label>Service de médecine interne et rhumatologie<institution>Hôpital de la source</institution><institution>CHR Orléans</institution><addr-line>Orleans,FR</addr-line></aff><aff id="A5"><label>5</label>Service de Rhumatologie<institution>CHU Nantes</institution><institution>Hôtel-Dieu</institution><addr-line>Nantes,FR</addr-line></aff><aff id="A6"><label>6</label>Service de Rhumatologie<institution>Hôpital Michallon</institution><institution>CHU Grenoble</institution><institution>Université Joseph Fourier - Grenoble I</institution><addr-line>Grenoble,FR</addr-line></aff><aff id="A7"><label>7</label>Service de Gastroentérologie<institution>CHU Rennes</institution><institution>Hôpital Pontchaillou</institution><addr-line>2 Rue Henri le Guilloux 35033 Rennes,FR</addr-line></aff><aff id="A8"><label>8</label>Service de Rhumatologie<institution>Hôpital de St Brieuc</institution><addr-line>St Brieuc,FR</addr-line></aff><aff id="A9"><label>9</label>Service de rhumatologie<institution>CHU Bordeaux</institution><addr-line>FR</addr-line></aff><aff id="A10"><label>10</label>Service de médecine interne<institution>AP-HP</institution><institution>Hôpital Cochin</institution><institution>Université Paris Descartes</institution><addr-line>27 rue du Faubourg Saint Antoine, 75679 Paris Cedex 14, France,FR</addr-line></aff><aff id="A11"><label>11</label>Service de gastro-entérologie<institution>AP-HP</institution><institution>Hôpital Saint-Louis</institution><addr-line>Paris, FR</addr-line></aff><aff id="A12"><label>12</label>Service d'hématologie biologique<institution>AP-HP</institution><institution>Hôpital Necker - Enfants Malades</institution><institution>Université Paris Descartes</institution><addr-line>Paris,FR</addr-line></aff><aff id="A13"><label>13</label>Laboratoire d'Hématologie<institution>AP-HP</institution><institution>Université Paris Sud - Paris XI</institution><institution>Hôpital Bicêtre</institution><addr-line>FR</addr-line></aff><author-notes><corresp id="FN1">* Correspondence should be adressed to: Pr Xavier MARIETTE <email>xavier.mariette@bct.ap-hop-paris.fr</email></corresp><fn id="FN2"><label>#</label><p>the two authors contributed equally to the work</p></fn></author-notes><pub-date pub-type="ppub"><month>2</month><year>2010</year></pub-date><pub-date pub-type="epub"><day>14</day><month>10</month><year>2009</year></pub-date><pub-date pub-type="pmc-release"><day>23</day><month>8</month><year>2010</year></pub-date><volume>69</volume><issue>2</issue><fpage>400</fpage><lpage>408</lpage><abstract><sec id="S1"><title>Objective</title><p id="P1">To describe cases of lymphoma associated with anti-TNF therapy, identify risk factors, estimate the incidence and compare risks for different anti-TNF agents.</p></sec><sec id="S2"><title>Methods</title><p id="P2">We designed a national prospective registry (RATIO) from 2004 to 2006, for collecting all cases of lymphoma in French patients receiving anti-TNF therapy, whatever the indication. We conducted a case-control analysis including two controls treated with anti-TNF per case and an incidence study of lymphoma with the French population used as reference..</p></sec><sec id="S3"><title>Results</title><p id="P3">We collected 38 cases of lymphoma, 31 non-Hodgkin’s lymphoma (NHL) (26 B-cell and 5 T-cell), 5 Hodgkin’s lymphoma (HL) and 2 Hodgkin’s-like lymphoma. Epstein-Barr virus (EBV) was detected in 2 of 2 Hodgkin’s-like lymphoma, 3 of 5 HL and one NHL. Patients receiving adalimumab or infliximab had a higher risk than those treated with etanercept: SIR = 4.1 (2.3–7.1) and 3.6 (2.3–5.6) versus 0.9 (0.4– 1.8). The exposure to adalimumab or infliximab versus etanercept was an independent risk factor for lymphoma in the case-control study: odds ratio=4.7 (1.3– 17.7) and 4.1 (1.4–12.5), respectively. The sex and age- adjusted incidence rate of lymphoma was 42.1 per 100,000 patient-years. The standardized incidence ratio (SIR) was 2.4 (95% confidence interval [CI] 1.7–3.2).</p></sec><sec id="S4"><title>Conclusion</title><p id="P4">Some lymphomas associated with immunosuppression may occur in patients receiving anti TNF therapy, and the risk of lymphoma is higher with monoclonal-antibody therapy than with soluble-receptor therapy.</p></sec></abstract><kwd-group kwd-group-type="MESH"><kwd>Aged</kwd><kwd>Antirheumatic Agents</kwd><kwd>adverse effects</kwd><kwd>therapeutic use</kwd><kwd>Arthritis</kwd><kwd>drug therapy</kwd><kwd>Epidemiologic Methods</kwd><kwd>Female</kwd><kwd>France</kwd><kwd>epidemiology</kwd><kwd>Humans</kwd><kwd>Immunocompromised Host</kwd><kwd>Immunosuppressive Agents</kwd><kwd>adverse effects</kwd><kwd>therapeutic use</kwd><kwd>Lymphoma</kwd><kwd>chemically induced</kwd><kwd>epidemiology</kwd><kwd>immunology</kwd><kwd>Male</kwd><kwd>Middle Aged</kwd><kwd>Registries</kwd><kwd>Tumor Necrosis Factor-alpha</kwd><kwd>antagonists & inhibitors</kwd></kwd-group><kwd-group kwd-group-type="Author"><kwd>Anti-TNF</kwd><kwd>Lymphoma</kwd><kwd>Safety</kwd><kwd>Rheumatoid arthritis</kwd><kwd>Spondylarthropathies</kwd></kwd-group></article-meta></front></pmc><affiliations><list></list><tree><noCountry><name sortKey="Bagheri, Haleh" sort="Bagheri, Haleh" uniqKey="Bagheri H" first="Haleh" last="Bagheri">Haleh Bagheri</name><name sortKey="Bardet, Michel" sort="Bardet, Michel" uniqKey="Bardet M" first="Michel" last="Bardet">Michel Bardet</name><name sortKey="Berthelot, Jean Marie" sort="Berthelot, Jean Marie" uniqKey="Berthelot J" first="Jean-Marie" last="Berthelot">Jean-Marie Berthelot</name><name sortKey="Gaudin, Philippe" sort="Gaudin, Philippe" uniqKey="Gaudin P" first="Philippe" last="Gaudin">Philippe Gaudin</name><name sortKey="Heresbach, Denis" sort="Heresbach, Denis" uniqKey="Heresbach D" first="Denis" last="Heresbach">Denis Heresbach</name><name sortKey="Hermine, Olivier" sort="Hermine, Olivier" uniqKey="Hermine O" first="Olivier" last="Hermine">Olivier Hermine</name><name sortKey="Lemann, Marc" sort="Lemann, Marc" uniqKey="Lemann M" first="Marc" last="Lemann">Marc Lemann</name><name sortKey="Mariette, Xavier" sort="Mariette, Xavier" uniqKey="Mariette X" first="Xavier" last="Mariette">Xavier Mariette</name><name sortKey="Martin, Antoine" sort="Martin, Antoine" uniqKey="Martin A" first="Antoine" last="Martin">Antoine Martin</name><name sortKey="Raphael, Martine" sort="Raphael, Martine" uniqKey="Raphael M" first="Martine" last="Raphael">Martine Raphael</name><name sortKey="Ravaud, Philippe" sort="Ravaud, Philippe" uniqKey="Ravaud P" first="Philippe" last="Ravaud">Philippe Ravaud</name><name sortKey="Salmon, Dominique" sort="Salmon, Dominique" uniqKey="Salmon D" first="Dominique" last="Salmon">Dominique Salmon</name><name sortKey="Schaeverbeke, Thierry" sort="Schaeverbeke, Thierry" uniqKey="Schaeverbeke T" first="Thierry" last="Schaeverbeke">Thierry Schaeverbeke</name><name sortKey="Tubach, Florence" sort="Tubach, Florence" uniqKey="Tubach F" first="Florence" last="Tubach">Florence Tubach</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/France/explor/LeHavreV1/Data/Pmc/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000115 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Checkpoint/biblio.hfd -nk 000115 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/France
|area= LeHavreV1
|flux= Pmc
|étape= Checkpoint
|type= RBID
|clé= PMC:2925048
|texte= Lymphoma in patients treated with anti-TNF: results of the 3-year prospective French RATIO registry
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Checkpoint/RBID.i -Sk "pubmed:19828563" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Checkpoint/biblio.hfd \
| NlmPubMed2Wicri -a LeHavreV1
| This area was generated with Dilib version V0.6.25. |  |