Non-TNF-Targeted Biologic vs a Second Anti-TNF Drug to Treat Rheumatoid Arthritis in Patients With Insufficient Response to a First Anti-TNF Drug: A Randomized Clinical Trial.
Identifieur interne : 000046 ( Main/Merge ); précédent : 000045; suivant : 000047Non-TNF-Targeted Biologic vs a Second Anti-TNF Drug to Treat Rheumatoid Arthritis in Patients With Insufficient Response to a First Anti-TNF Drug: A Randomized Clinical Trial.
Auteurs : Jacques-Eric Gottenberg [France] ; Olivier Brocq [Monaco] ; Aleth Perdriger [France] ; Slim Lassoued [France] ; Jean-Marie Berthelot [France] ; Daniel Wendling [France] ; Liana Euller-Ziegler [France] ; Martin Soubrier [France] ; Christophe Richez [France] ; Bruno Fautrel [France] ; Arnaud L. Constantin [France] ; Xavier Mariette [France] ; Jacques Morel [France] ; Melanie Gilson [France] ; Gregoire Cormier [France] ; Jean Hugues Salmon [France] ; Stephanie Rist [France] ; Frederic Lioté [France] ; Hubert Marotte [France] ; Christine Bonnet [France] ; Christian Marcelli ; Jeremie Sellam [France] ; Olivier Meyer [France] ; Elisabeth Solau-Gervais [France] ; Sandrine Guis [France] ; Jean-Marc Ziza [France] ; Charles Zarnitsky [France] ; Isabelle Chary-Valckenaere [France] ; Olivier Vittecoq [France] ; Alain Saraux [France] ; Yves-Marie Pers [France] ; Martine Gayraud [France] ; Gilles Bolla [France] ; Pascal Claudepierre [France] ; Marc Ardizzone [France] ; Emmanuelle Dernis [France] ; Maxime A. Breban [France] ; Olivier Fain [France] ; Jean-Charles Balblanc [France] ; Ouafaa Aberkane [France] ; Marion Vazel [France] ; Christelle Back [France] ; Sophie Candon [France] ; Lucienne Chatenoud [France] ; Elodie Perrodeau [France] ; Jean Sibilia [France] ; Philippe Ravaud [France]Source :
- JAMA [ 1538-3598 ] ; 2016.
Abstract
One-third of patients with rheumatoid arthritis show inadequate response to tumor necrosis factor α (TNF-α) inhibitors; little guidance on choosing the next treatment exists.
Url:
DOI: 10.1001/jama.2016.13512
PubMed: 27654603
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Nice</wicri:regionArea><placeName><settlement type="city">Nice</settlement></placeName></affiliation></author><author><name sortKey="Soubrier, Martin" sort="Soubrier, Martin" uniqKey="Soubrier M" first="Martin" last="Soubrier">Martin Soubrier</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Clermont-Ferrand University Hospital, Clermont-Ferrand, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Clermont-Ferrand University Hospital, Clermont-Ferrand</wicri:regionArea><placeName><settlement type="city">Clermont-Ferrand</settlement></placeName></affiliation></author><author><name sortKey="Richez, Christophe" sort="Richez, Christophe" uniqKey="Richez C" first="Christophe" last="Richez">Christophe Richez</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Bordeaux University Hospital, Bordeaux, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Bordeaux University Hospital, Bordeaux</wicri:regionArea><placeName><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Fautrel, Bruno" sort="Fautrel, Bruno" uniqKey="Fautrel B" first="Bruno" last="Fautrel">Bruno Fautrel</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Hôpital La Pitié Salpétrière, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Hôpital La Pitié Salpétrière, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Constantin, Arnaud L" sort="Constantin, Arnaud L" uniqKey="Constantin A" first="Arnaud L" last="Constantin">Arnaud L. Constantin</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Toulouse University Hospital, Toulouse, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Toulouse University Hospital, Toulouse</wicri:regionArea><placeName><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Mariette, Xavier" sort="Mariette, Xavier" uniqKey="Mariette X" first="Xavier" last="Mariette">Xavier Mariette</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Hôpital Kremlin Bicêtre, Kremlin Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Hôpital Kremlin Bicêtre, Kremlin Bicêtre</wicri:regionArea><wicri:noRegion>Kremlin Bicêtre</wicri:noRegion><wicri:noRegion>Kremlin Bicêtre</wicri:noRegion></affiliation></author><author><name sortKey="Morel, Jacques" sort="Morel, Jacques" uniqKey="Morel J" first="Jacques" last="Morel">Jacques Morel</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Montpellier University Hospital, Montpellier, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Montpellier University Hospital, Montpellier</wicri:regionArea><placeName><settlement type="city">Montpellier</settlement></placeName></affiliation></author><author><name sortKey="Gilson, Melanie" sort="Gilson, Melanie" uniqKey="Gilson M" first="Melanie" last="Gilson">Melanie Gilson</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Grenoble University Hospital, Grenoble, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Grenoble University Hospital, Grenoble</wicri:regionArea><placeName><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Cormier, Gregoire" sort="Cormier, Gregoire" uniqKey="Cormier G" first="Gregoire" last="Cormier">Gregoire Cormier</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Centre Hospitalier de La Roche Sur Yon, La Roche Sur Yon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Centre Hospitalier de La Roche Sur Yon, La Roche Sur Yon</wicri:regionArea><placeName><settlement type="city">La Roche-sur-Yon</settlement></placeName></affiliation></author><author><name sortKey="Salmon, Jean Hugues" sort="Salmon, Jean Hugues" uniqKey="Salmon J" first="Jean Hugues" last="Salmon">Jean Hugues Salmon</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Reims University Hospital, Reims, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Reims University Hospital, Reims</wicri:regionArea><placeName><settlement type="city">Reims</settlement></placeName></affiliation></author><author><name sortKey="Rist, Stephanie" sort="Rist, Stephanie" uniqKey="Rist S" first="Stephanie" last="Rist">Stephanie Rist</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Centre Hospitalier d'Orléans, Orléans, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Centre Hospitalier d'Orléans, Orléans</wicri:regionArea><placeName><settlement type="city">Orléans</settlement></placeName></affiliation></author><author><name sortKey="Liote, Frederic" sort="Liote, Frederic" uniqKey="Liote F" first="Frederic" last="Lioté">Frederic Lioté</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Hôpital Lariboisière, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Hôpital Lariboisière, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Marotte, Hubert" sort="Marotte, Hubert" uniqKey="Marotte H" first="Hubert" last="Marotte">Hubert Marotte</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Saint-Etienne University Hospital, Saint-Etienne, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Saint-Etienne University Hospital, Saint-Etienne</wicri:regionArea><placeName><settlement type="city">Saint-Étienne</settlement></placeName></affiliation></author><author><name sortKey="Bonnet, Christine" sort="Bonnet, Christine" uniqKey="Bonnet C" first="Christine" last="Bonnet">Christine Bonnet</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Limoges University Hospital, Limoges, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Limoges University Hospital, Limoges</wicri:regionArea><placeName><settlement type="city">Limoges</settlement></placeName></affiliation></author><author><name sortKey="Marcelli, Christian" sort="Marcelli, Christian" uniqKey="Marcelli C" first="Christian" last="Marcelli">Christian Marcelli</name><affiliation><nlm:affiliation>Department of Rheumatology, Caen University Hospital, Caen France.</nlm:affiliation><wicri:noCountry code="subField">Caen France</wicri:noCountry></affiliation></author><author><name sortKey="Sellam, Jeremie" sort="Sellam, Jeremie" uniqKey="Sellam J" first="Jeremie" last="Sellam">Jeremie Sellam</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Hôpital Saint-Antoine, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Hôpital Saint-Antoine, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Meyer, Olivier" sort="Meyer, Olivier" uniqKey="Meyer O" first="Olivier" last="Meyer">Olivier Meyer</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Hôpital Bichat, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Hôpital Bichat, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Solau Gervais, Elisabeth" sort="Solau Gervais, Elisabeth" uniqKey="Solau Gervais E" first="Elisabeth" last="Solau-Gervais">Elisabeth Solau-Gervais</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Poitiers University Hospital, Poitiers, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Poitiers University Hospital, Poitiers</wicri:regionArea><placeName><settlement type="city">Poitiers</settlement></placeName></affiliation></author><author><name sortKey="Guis, Sandrine" sort="Guis, Sandrine" uniqKey="Guis S" first="Sandrine" last="Guis">Sandrine Guis</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Marseille University Hospital, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Marseille University Hospital, Marseille</wicri:regionArea><placeName><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Ziza, Jean Marc" sort="Ziza, Jean Marc" uniqKey="Ziza J" first="Jean-Marc" last="Ziza">Jean-Marc Ziza</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Hôpital La Croix Saint Simon, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Hôpital La Croix Saint Simon, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Zarnitsky, Charles" sort="Zarnitsky, Charles" uniqKey="Zarnitsky C" first="Charles" last="Zarnitsky">Charles Zarnitsky</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Centre Hospitalier du Havre, Le Havre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Centre Hospitalier du Havre, Le Havre</wicri:regionArea><placeName><settlement type="city">Le Havre</settlement></placeName></affiliation></author><author><name sortKey="Chary Valckenaere, Isabelle" sort="Chary Valckenaere, Isabelle" uniqKey="Chary Valckenaere I" first="Isabelle" last="Chary-Valckenaere">Isabelle Chary-Valckenaere</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Nancy University Hospital, Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Nancy University Hospital, Nancy</wicri:regionArea><placeName><settlement type="city">Nancy</settlement></placeName></affiliation></author><author><name sortKey="Vittecoq, Olivier" sort="Vittecoq, Olivier" uniqKey="Vittecoq O" first="Olivier" last="Vittecoq">Olivier Vittecoq</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Rouen University Hospital, Rouen, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Rouen University Hospital, Rouen</wicri:regionArea><placeName><settlement type="city">Rouen</settlement></placeName></affiliation></author><author><name sortKey="Saraux, Alain" sort="Saraux, Alain" uniqKey="Saraux A" first="Alain" last="Saraux">Alain Saraux</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Brest University Hospital, Brest, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Brest University Hospital, Brest</wicri:regionArea><placeName><settlement type="city">Brest</settlement></placeName></affiliation></author><author><name sortKey="Pers, Yves Marie" sort="Pers, Yves Marie" uniqKey="Pers Y" first="Yves-Marie" last="Pers">Yves-Marie Pers</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Montpellier University Hospital, Montpellier, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Montpellier University Hospital, Montpellier</wicri:regionArea><placeName><settlement type="city">Montpellier</settlement></placeName></affiliation></author><author><name sortKey="Gayraud, Martine" sort="Gayraud, Martine" uniqKey="Gayraud M" first="Martine" last="Gayraud">Martine Gayraud</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine, Institut Montsouris, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Internal Medicine, Institut Montsouris, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Bolla, Gilles" sort="Bolla, Gilles" uniqKey="Bolla G" first="Gilles" last="Bolla">Gilles Bolla</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Centre Hospitalier de Cannes, Cannes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Centre Hospitalier de Cannes, Cannes</wicri:regionArea><wicri:noRegion>Cannes</wicri:noRegion><wicri:noRegion>Cannes</wicri:noRegion></affiliation></author><author><name sortKey="Claudepierre, Pascal" sort="Claudepierre, Pascal" uniqKey="Claudepierre P" first="Pascal" last="Claudepierre">Pascal Claudepierre</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Hôpital Mondor, Créteil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Hôpital Mondor, Créteil</wicri:regionArea><placeName><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="Ardizzone, Marc" sort="Ardizzone, Marc" uniqKey="Ardizzone M" first="Marc" last="Ardizzone">Marc Ardizzone</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Centre Hospitalier de Mulhouse, Mulhouse, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Centre Hospitalier de Mulhouse, Mulhouse</wicri:regionArea><placeName><settlement type="city">Mulhouse</settlement></placeName></affiliation></author><author><name sortKey="Dernis, Emmanuelle" sort="Dernis, Emmanuelle" uniqKey="Dernis E" first="Emmanuelle" last="Dernis">Emmanuelle Dernis</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Centre Hospitalier du Mans, Le Mans, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Centre Hospitalier du Mans, Le Mans</wicri:regionArea><placeName><settlement type="city">Le Mans</settlement></placeName></affiliation></author><author><name sortKey="Breban, Maxime A" sort="Breban, Maxime A" uniqKey="Breban M" first="Maxime A" last="Breban">Maxime A. Breban</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Hôpital Ambroise Paré, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Hôpital Ambroise Paré, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Fain, Olivier" sort="Fain, Olivier" uniqKey="Fain O" first="Olivier" last="Fain">Olivier Fain</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine, Hôpital Saint-Antoine, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Internal Medicine, Hôpital Saint-Antoine, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Balblanc, Jean Charles" sort="Balblanc, Jean Charles" uniqKey="Balblanc J" first="Jean-Charles" last="Balblanc">Jean-Charles Balblanc</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Centre Hospitalier de Belfort, Belfort, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Centre Hospitalier de Belfort, Belfort</wicri:regionArea><placeName><settlement type="city">Belfort</settlement></placeName></affiliation></author><author><name sortKey="Aberkane, Ouafaa" sort="Aberkane, Ouafaa" uniqKey="Aberkane O" first="Ouafaa" last="Aberkane">Ouafaa Aberkane</name><affiliation wicri:level="1"><nlm:affiliation>Department of Direction de la recherche clinique et de l'innovation, Strasbourg University Hospital, Strasbourg, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Direction de la recherche clinique et de l'innovation, Strasbourg University Hospital, Strasbourg</wicri:regionArea><placeName><settlement type="city">Strasbourg</settlement></placeName></affiliation></author><author><name sortKey="Vazel, Marion" sort="Vazel, Marion" uniqKey="Vazel M" first="Marion" last="Vazel">Marion Vazel</name><affiliation wicri:level="1"><nlm:affiliation>Department of Direction de la recherche clinique et de l'innovation, Strasbourg University Hospital, Strasbourg, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Direction de la recherche clinique et de l'innovation, Strasbourg University Hospital, Strasbourg</wicri:regionArea><placeName><settlement type="city">Strasbourg</settlement></placeName></affiliation></author><author><name sortKey="Back, Christelle" sort="Back, Christelle" uniqKey="Back C" first="Christelle" last="Back">Christelle Back</name><affiliation wicri:level="1"><nlm:affiliation>Department of Direction de la recherche clinique et de l'innovation, Strasbourg University Hospital, Strasbourg, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Direction de la recherche clinique et de l'innovation, Strasbourg University Hospital, Strasbourg</wicri:regionArea><placeName><settlement type="city">Strasbourg</settlement></placeName></affiliation></author><author><name sortKey="Candon, Sophie" sort="Candon, Sophie" uniqKey="Candon S" first="Sophie" last="Candon">Sophie Candon</name><affiliation wicri:level="1"><nlm:affiliation>Department of Immunology, Hôpital Necker, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Immunology, Hôpital Necker, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Chatenoud, Lucienne" sort="Chatenoud, Lucienne" uniqKey="Chatenoud L" first="Lucienne" last="Chatenoud">Lucienne Chatenoud</name><affiliation wicri:level="1"><nlm:affiliation>Department of Immunology, Hôpital Necker, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Immunology, Hôpital Necker, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Perrodeau, Elodie" sort="Perrodeau, Elodie" uniqKey="Perrodeau E" first="Elodie" last="Perrodeau">Elodie Perrodeau</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology and Biostatistics, Hotel Dieu, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Epidemiology and Biostatistics, Hotel Dieu, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Sibilia, Jean" sort="Sibilia, Jean" uniqKey="Sibilia J" first="Jean" last="Sibilia">Jean Sibilia</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, National Reference Center for Systemic Autoimmune Diseases, Strasbourg University Hospital, Université de Strasbourg, Strasbourg, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, National Reference Center for Systemic Autoimmune Diseases, Strasbourg University Hospital, Université de Strasbourg, Strasbourg</wicri:regionArea><placeName><settlement type="city">Strasbourg</settlement></placeName></affiliation></author><author><name sortKey="Ravaud, Philippe" sort="Ravaud, Philippe" uniqKey="Ravaud P" first="Philippe" last="Ravaud">Philippe Ravaud</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology and Biostatistics, Hotel Dieu, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Epidemiology and Biostatistics, Hotel Dieu, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27654603</idno><idno type="pmid">27654603</idno><idno type="doi">10.1001/jama.2016.13512</idno><idno type="wicri:Area/PubMed/Corpus">000013</idno><idno type="wicri:Area/PubMed/Curation">000013</idno><idno type="wicri:Area/PubMed/Checkpoint">000013</idno><idno type="wicri:Area/Ncbi/Merge">000567</idno><idno type="wicri:Area/Ncbi/Curation">000567</idno><idno type="wicri:Area/Ncbi/Checkpoint">000567</idno><idno type="wicri:source">HAL</idno><idno type="RBID">Hal:hal-01374313</idno><idno type="url">https://hal.archives-ouvertes.fr/hal-01374313</idno><idno type="wicri:Area/Hal/Corpus">000237</idno><idno type="wicri:Area/Hal/Curation">000237</idno><idno type="wicri:Area/Hal/Checkpoint">000002</idno><idno type="wicri:doubleKey">0098-7484:2016:Gottenberg J:non:tnf:targeted</idno><idno type="wicri:Area/Main/Merge">000046</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Non-TNF-Targeted Biologic vs a Second Anti-TNF Drug to Treat Rheumatoid Arthritis in Patients With Insufficient Response to a First Anti-TNF Drug: A Randomized Clinical Trial.</title><author><name sortKey="Gottenberg, Jacques Eric" sort="Gottenberg, Jacques Eric" uniqKey="Gottenberg J" first="Jacques-Eric" last="Gottenberg">Jacques-Eric Gottenberg</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, National Reference Center for Systemic Autoimmune Diseases, Strasbourg University Hospital, Université de Strasbourg, Strasbourg, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, National Reference Center for Systemic Autoimmune Diseases, Strasbourg University Hospital, Université de Strasbourg, Strasbourg</wicri:regionArea><placeName><settlement type="city">Strasbourg</settlement></placeName></affiliation></author><author><name sortKey="Brocq, Olivier" sort="Brocq, Olivier" uniqKey="Brocq O" first="Olivier" last="Brocq">Olivier Brocq</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Centre Hospitalier Princesse Grâce, Monaco.</nlm:affiliation><country xml:lang="fr">Monaco</country><wicri:regionArea>Department of Rheumatology, Centre Hospitalier Princesse Grâce</wicri:regionArea><wicri:noRegion>Centre Hospitalier Princesse Grâce</wicri:noRegion></affiliation></author><author><name sortKey="Perdriger, Aleth" sort="Perdriger, Aleth" uniqKey="Perdriger A" first="Aleth" last="Perdriger">Aleth Perdriger</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Rennes University Hospital, Rennes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Rennes University Hospital, Rennes</wicri:regionArea><placeName><settlement type="city">Rennes</settlement></placeName></affiliation></author><author><name sortKey="Lassoued, Slim" sort="Lassoued, Slim" uniqKey="Lassoued S" first="Slim" last="Lassoued">Slim Lassoued</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Centre Hospitalier de Cahors, Cahors, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Centre Hospitalier de Cahors, Cahors</wicri:regionArea><placeName><settlement type="city">Cahors</settlement></placeName></affiliation></author><author><name sortKey="Berthelot, Jean Marie" sort="Berthelot, Jean Marie" uniqKey="Berthelot J" first="Jean-Marie" last="Berthelot">Jean-Marie Berthelot</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Nantes University Hospital, Nantes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Nantes University Hospital, Nantes</wicri:regionArea><placeName><settlement type="city">Nantes</settlement></placeName></affiliation></author><author><name sortKey="Wendling, Daniel" sort="Wendling, Daniel" uniqKey="Wendling D" first="Daniel" last="Wendling">Daniel Wendling</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Besançon University Hospital, Besançon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Besançon University Hospital, Besançon</wicri:regionArea><placeName><settlement type="city">Besançon</settlement></placeName></affiliation></author><author><name sortKey="Euller Ziegler, Liana" sort="Euller Ziegler, Liana" uniqKey="Euller Ziegler L" first="Liana" last="Euller-Ziegler">Liana Euller-Ziegler</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Nice University Hospital, Nice, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Nice University Hospital, Nice</wicri:regionArea><placeName><settlement type="city">Nice</settlement></placeName></affiliation></author><author><name sortKey="Soubrier, Martin" sort="Soubrier, Martin" uniqKey="Soubrier M" first="Martin" last="Soubrier">Martin Soubrier</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Clermont-Ferrand University Hospital, Clermont-Ferrand, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Clermont-Ferrand University Hospital, Clermont-Ferrand</wicri:regionArea><placeName><settlement type="city">Clermont-Ferrand</settlement></placeName></affiliation></author><author><name sortKey="Richez, Christophe" sort="Richez, Christophe" uniqKey="Richez C" first="Christophe" last="Richez">Christophe Richez</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Bordeaux University Hospital, Bordeaux, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Bordeaux University Hospital, Bordeaux</wicri:regionArea><placeName><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Fautrel, Bruno" sort="Fautrel, Bruno" uniqKey="Fautrel B" first="Bruno" last="Fautrel">Bruno Fautrel</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Hôpital La Pitié Salpétrière, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Hôpital La Pitié Salpétrière, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Constantin, Arnaud L" sort="Constantin, Arnaud L" uniqKey="Constantin A" first="Arnaud L" last="Constantin">Arnaud L. Constantin</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Toulouse University Hospital, Toulouse, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Toulouse University Hospital, Toulouse</wicri:regionArea><placeName><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Mariette, Xavier" sort="Mariette, Xavier" uniqKey="Mariette X" first="Xavier" last="Mariette">Xavier Mariette</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Hôpital Kremlin Bicêtre, Kremlin Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Hôpital Kremlin Bicêtre, Kremlin Bicêtre</wicri:regionArea><wicri:noRegion>Kremlin Bicêtre</wicri:noRegion><wicri:noRegion>Kremlin Bicêtre</wicri:noRegion></affiliation></author><author><name sortKey="Morel, Jacques" sort="Morel, Jacques" uniqKey="Morel J" first="Jacques" last="Morel">Jacques Morel</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Montpellier University Hospital, Montpellier, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Montpellier University Hospital, Montpellier</wicri:regionArea><placeName><settlement type="city">Montpellier</settlement></placeName></affiliation></author><author><name sortKey="Gilson, Melanie" sort="Gilson, Melanie" uniqKey="Gilson M" first="Melanie" last="Gilson">Melanie Gilson</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Grenoble University Hospital, Grenoble, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Grenoble University Hospital, Grenoble</wicri:regionArea><placeName><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Cormier, Gregoire" sort="Cormier, Gregoire" uniqKey="Cormier G" first="Gregoire" last="Cormier">Gregoire Cormier</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Centre Hospitalier de La Roche Sur Yon, La Roche Sur Yon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Centre Hospitalier de La Roche Sur Yon, La Roche Sur Yon</wicri:regionArea><placeName><settlement type="city">La Roche-sur-Yon</settlement></placeName></affiliation></author><author><name sortKey="Salmon, Jean Hugues" sort="Salmon, Jean Hugues" uniqKey="Salmon J" first="Jean Hugues" last="Salmon">Jean Hugues Salmon</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Reims University Hospital, Reims, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Reims University Hospital, Reims</wicri:regionArea><placeName><settlement type="city">Reims</settlement></placeName></affiliation></author><author><name sortKey="Rist, Stephanie" sort="Rist, Stephanie" uniqKey="Rist S" first="Stephanie" last="Rist">Stephanie Rist</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Centre Hospitalier d'Orléans, Orléans, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Centre Hospitalier d'Orléans, Orléans</wicri:regionArea><placeName><settlement type="city">Orléans</settlement></placeName></affiliation></author><author><name sortKey="Liote, Frederic" sort="Liote, Frederic" uniqKey="Liote F" first="Frederic" last="Lioté">Frederic Lioté</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Hôpital Lariboisière, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Hôpital Lariboisière, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Marotte, Hubert" sort="Marotte, Hubert" uniqKey="Marotte H" first="Hubert" last="Marotte">Hubert Marotte</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Saint-Etienne University Hospital, Saint-Etienne, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Saint-Etienne University Hospital, Saint-Etienne</wicri:regionArea><placeName><settlement type="city">Saint-Étienne</settlement></placeName></affiliation></author><author><name sortKey="Bonnet, Christine" sort="Bonnet, Christine" uniqKey="Bonnet C" first="Christine" last="Bonnet">Christine Bonnet</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Limoges University Hospital, Limoges, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Limoges University Hospital, Limoges</wicri:regionArea><placeName><settlement type="city">Limoges</settlement></placeName></affiliation></author><author><name sortKey="Marcelli, Christian" sort="Marcelli, Christian" uniqKey="Marcelli C" first="Christian" last="Marcelli">Christian Marcelli</name><affiliation><nlm:affiliation>Department of Rheumatology, Caen University Hospital, Caen France.</nlm:affiliation><wicri:noCountry code="subField">Caen France</wicri:noCountry></affiliation></author><author><name sortKey="Sellam, Jeremie" sort="Sellam, Jeremie" uniqKey="Sellam J" first="Jeremie" last="Sellam">Jeremie Sellam</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Hôpital Saint-Antoine, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Hôpital Saint-Antoine, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Meyer, Olivier" sort="Meyer, Olivier" uniqKey="Meyer O" first="Olivier" last="Meyer">Olivier Meyer</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Hôpital Bichat, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Hôpital Bichat, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Solau Gervais, Elisabeth" sort="Solau Gervais, Elisabeth" uniqKey="Solau Gervais E" first="Elisabeth" last="Solau-Gervais">Elisabeth Solau-Gervais</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Poitiers University Hospital, Poitiers, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Poitiers University Hospital, Poitiers</wicri:regionArea><placeName><settlement type="city">Poitiers</settlement></placeName></affiliation></author><author><name sortKey="Guis, Sandrine" sort="Guis, Sandrine" uniqKey="Guis S" first="Sandrine" last="Guis">Sandrine Guis</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Marseille University Hospital, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Marseille University Hospital, Marseille</wicri:regionArea><placeName><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Ziza, Jean Marc" sort="Ziza, Jean Marc" uniqKey="Ziza J" first="Jean-Marc" last="Ziza">Jean-Marc Ziza</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Hôpital La Croix Saint Simon, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Hôpital La Croix Saint Simon, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Zarnitsky, Charles" sort="Zarnitsky, Charles" uniqKey="Zarnitsky C" first="Charles" last="Zarnitsky">Charles Zarnitsky</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Centre Hospitalier du Havre, Le Havre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Centre Hospitalier du Havre, Le Havre</wicri:regionArea><placeName><settlement type="city">Le Havre</settlement></placeName></affiliation></author><author><name sortKey="Chary Valckenaere, Isabelle" sort="Chary Valckenaere, Isabelle" uniqKey="Chary Valckenaere I" first="Isabelle" last="Chary-Valckenaere">Isabelle Chary-Valckenaere</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Nancy University Hospital, Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Nancy University Hospital, Nancy</wicri:regionArea><placeName><settlement type="city">Nancy</settlement></placeName></affiliation></author><author><name sortKey="Vittecoq, Olivier" sort="Vittecoq, Olivier" uniqKey="Vittecoq O" first="Olivier" last="Vittecoq">Olivier Vittecoq</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Rouen University Hospital, Rouen, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Rouen University Hospital, Rouen</wicri:regionArea><placeName><settlement type="city">Rouen</settlement></placeName></affiliation></author><author><name sortKey="Saraux, Alain" sort="Saraux, Alain" uniqKey="Saraux A" first="Alain" last="Saraux">Alain Saraux</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Brest University Hospital, Brest, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Brest University Hospital, Brest</wicri:regionArea><placeName><settlement type="city">Brest</settlement></placeName></affiliation></author><author><name sortKey="Pers, Yves Marie" sort="Pers, Yves Marie" uniqKey="Pers Y" first="Yves-Marie" last="Pers">Yves-Marie Pers</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Montpellier University Hospital, Montpellier, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Montpellier University Hospital, Montpellier</wicri:regionArea><placeName><settlement type="city">Montpellier</settlement></placeName></affiliation></author><author><name sortKey="Gayraud, Martine" sort="Gayraud, Martine" uniqKey="Gayraud M" first="Martine" last="Gayraud">Martine Gayraud</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine, Institut Montsouris, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Internal Medicine, Institut Montsouris, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Bolla, Gilles" sort="Bolla, Gilles" uniqKey="Bolla G" first="Gilles" last="Bolla">Gilles Bolla</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Centre Hospitalier de Cannes, Cannes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Centre Hospitalier de Cannes, Cannes</wicri:regionArea><wicri:noRegion>Cannes</wicri:noRegion><wicri:noRegion>Cannes</wicri:noRegion></affiliation></author><author><name sortKey="Claudepierre, Pascal" sort="Claudepierre, Pascal" uniqKey="Claudepierre P" first="Pascal" last="Claudepierre">Pascal Claudepierre</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Hôpital Mondor, Créteil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Hôpital Mondor, Créteil</wicri:regionArea><placeName><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="Ardizzone, Marc" sort="Ardizzone, Marc" uniqKey="Ardizzone M" first="Marc" last="Ardizzone">Marc Ardizzone</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Centre Hospitalier de Mulhouse, Mulhouse, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Centre Hospitalier de Mulhouse, Mulhouse</wicri:regionArea><placeName><settlement type="city">Mulhouse</settlement></placeName></affiliation></author><author><name sortKey="Dernis, Emmanuelle" sort="Dernis, Emmanuelle" uniqKey="Dernis E" first="Emmanuelle" last="Dernis">Emmanuelle Dernis</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Centre Hospitalier du Mans, Le Mans, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Centre Hospitalier du Mans, Le Mans</wicri:regionArea><placeName><settlement type="city">Le Mans</settlement></placeName></affiliation></author><author><name sortKey="Breban, Maxime A" sort="Breban, Maxime A" uniqKey="Breban M" first="Maxime A" last="Breban">Maxime A. Breban</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Hôpital Ambroise Paré, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Hôpital Ambroise Paré, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Fain, Olivier" sort="Fain, Olivier" uniqKey="Fain O" first="Olivier" last="Fain">Olivier Fain</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine, Hôpital Saint-Antoine, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Internal Medicine, Hôpital Saint-Antoine, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Balblanc, Jean Charles" sort="Balblanc, Jean Charles" uniqKey="Balblanc J" first="Jean-Charles" last="Balblanc">Jean-Charles Balblanc</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Centre Hospitalier de Belfort, Belfort, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Centre Hospitalier de Belfort, Belfort</wicri:regionArea><placeName><settlement type="city">Belfort</settlement></placeName></affiliation></author><author><name sortKey="Aberkane, Ouafaa" sort="Aberkane, Ouafaa" uniqKey="Aberkane O" first="Ouafaa" last="Aberkane">Ouafaa Aberkane</name><affiliation wicri:level="1"><nlm:affiliation>Department of Direction de la recherche clinique et de l'innovation, Strasbourg University Hospital, Strasbourg, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Direction de la recherche clinique et de l'innovation, Strasbourg University Hospital, Strasbourg</wicri:regionArea><placeName><settlement type="city">Strasbourg</settlement></placeName></affiliation></author><author><name sortKey="Vazel, Marion" sort="Vazel, Marion" uniqKey="Vazel M" first="Marion" last="Vazel">Marion Vazel</name><affiliation wicri:level="1"><nlm:affiliation>Department of Direction de la recherche clinique et de l'innovation, Strasbourg University Hospital, Strasbourg, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Direction de la recherche clinique et de l'innovation, Strasbourg University Hospital, Strasbourg</wicri:regionArea><placeName><settlement type="city">Strasbourg</settlement></placeName></affiliation></author><author><name sortKey="Back, Christelle" sort="Back, Christelle" uniqKey="Back C" first="Christelle" last="Back">Christelle Back</name><affiliation wicri:level="1"><nlm:affiliation>Department of Direction de la recherche clinique et de l'innovation, Strasbourg University Hospital, Strasbourg, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Direction de la recherche clinique et de l'innovation, Strasbourg University Hospital, Strasbourg</wicri:regionArea><placeName><settlement type="city">Strasbourg</settlement></placeName></affiliation></author><author><name sortKey="Candon, Sophie" sort="Candon, Sophie" uniqKey="Candon S" first="Sophie" last="Candon">Sophie Candon</name><affiliation wicri:level="1"><nlm:affiliation>Department of Immunology, Hôpital Necker, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Immunology, Hôpital Necker, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Chatenoud, Lucienne" sort="Chatenoud, Lucienne" uniqKey="Chatenoud L" first="Lucienne" last="Chatenoud">Lucienne Chatenoud</name><affiliation wicri:level="1"><nlm:affiliation>Department of Immunology, Hôpital Necker, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Immunology, Hôpital Necker, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Perrodeau, Elodie" sort="Perrodeau, Elodie" uniqKey="Perrodeau E" first="Elodie" last="Perrodeau">Elodie Perrodeau</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology and Biostatistics, Hotel Dieu, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Epidemiology and Biostatistics, Hotel Dieu, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Sibilia, Jean" sort="Sibilia, Jean" uniqKey="Sibilia J" first="Jean" last="Sibilia">Jean Sibilia</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, National Reference Center for Systemic Autoimmune Diseases, Strasbourg University Hospital, Université de Strasbourg, Strasbourg, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, National Reference Center for Systemic Autoimmune Diseases, Strasbourg University Hospital, Université de Strasbourg, Strasbourg</wicri:regionArea><placeName><settlement type="city">Strasbourg</settlement></placeName></affiliation></author><author><name sortKey="Ravaud, Philippe" sort="Ravaud, Philippe" uniqKey="Ravaud P" first="Philippe" last="Ravaud">Philippe Ravaud</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology and Biostatistics, Hotel Dieu, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Epidemiology and Biostatistics, Hotel Dieu, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author></analytic><series><title level="j">JAMA</title><idno type="eISSN">1538-3598</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">One-third of patients with rheumatoid arthritis show inadequate response to tumor necrosis factor α (TNF-α) inhibitors; little guidance on choosing the next treatment exists.</div></front></TEI><double doi="10.1001/jama.2016.13512"><HAL><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Non–TNF-Targeted Biologic vs a Second Anti-TNF Drug to Treat Rheumatoid Arthritis in Patients With Insufficient Response to a First Anti-TNF Drug</title><author><name sortKey="Gottenberg, Jacques" sort="Gottenberg, Jacques" uniqKey="Gottenberg J" first="Jacques" last="Gottenberg">Jacques Gottenberg</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-222993" status="VALID"><orgName>Immuno-Rhumatologie 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</desc></org></tutelle><tutelle active="#struct-303171" type="indirect"><org type="institution" xml:id="struct-303171" status="VALID"><orgName>Université Sorbonne Paris Cité</orgName><orgName type="acronym">USPC</orgName><desc><address><country key="FR"></country></address><ref type="url">http://www.sorbonne-paris-cite.fr/fr</ref></desc></org></tutelle><tutelle name="U1153" active="#struct-303623" type="indirect"><org type="institution" xml:id="struct-303623" status="VALID"><idno type="IdRef">026388278</idno><orgName>Institut National de la Santé et de la Recherche Médicale</orgName><orgName type="acronym">INSERM</orgName><desc><address><addrLine>101, rue de Tolbiac, 75013 Paris </addrLine><country key="FR"></country></address><ref type="url">http://www.inserm.fr</ref></desc></org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Sibilia, Jean" sort="Sibilia, Jean" uniqKey="Sibilia J" first="Jean" last="Sibilia">Jean Sibilia</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-222993" status="VALID"><orgName>Immuno-Rhumatologie Moléculaire</orgName><desc><address><addrLine>1 Place de l'Hôpital 67000 Strasbourg</addrLine><country key="FR"></country></address></desc><listRelation><relation name="EA4438" active="#struct-302445" type="direct"></relation><relation name="U1109" active="#struct-303623" type="direct"></relation><relation active="#struct-303705" type="direct"></relation></listRelation><tutelles><tutelle name="EA4438" active="#struct-302445" type="direct"><org type="institution" xml:id="struct-302445" status="VALID"><orgName>Université de Strasbourg</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle><tutelle name="U1109" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"><idno type="IdRef">026388278</idno><orgName>Institut National de la Santé et de la Recherche Médicale</orgName><orgName type="acronym">INSERM</orgName><desc><address><addrLine>101, rue de Tolbiac, 75013 Paris </addrLine><country key="FR"></country></address><ref type="url">http://www.inserm.fr</ref></desc></org></tutelle><tutelle active="#struct-303705" type="direct"><org type="institution" xml:id="struct-303705" status="INCOMING"><orgName>Faculté de Médecine</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle></tutelles></hal:affiliation><country>France</country><placeName><settlement type="city">Strasbourg</settlement><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Alsace (région administrative)</region></placeName><orgName type="university">Université de Strasbourg</orgName></affiliation></author><author><name sortKey="Ravaud, Philippe" sort="Ravaud, Philippe" uniqKey="Ravaud P" first="Philippe" last="Ravaud">Philippe Ravaud</name><affiliation wicri:level="1"><hal:affiliation type="researchteam" xml:id="struct-405341" status="VALID"> <orgName>Equipe 5 : "METHODS" - Méthodes de l’évaluation thérapeutique des maladies chroniques</orgName> <orgName type="acronym">CRESS</orgName> <desc> <address> <addrLine>1 place du Parvis Notre-Dame 75004 Paris</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-446175" type="direct"></relation> <relation name="UR1125" active="#struct-92114" type="indirect"></relation> <relation active="#struct-301516" type="indirect"></relation> <relation active="#struct-303171" type="indirect"></relation> <relation name="U1153" active="#struct-303623" type="indirect"></relation> </listRelation><tutelles><tutelle active="#struct-446175" type="direct"><org type="laboratory" xml:id="struct-446175" status="VALID"> <orgName>Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité</orgName> <orgName type="acronym">CRESS</orgName> <desc> <address> <country key="FR"></country> </address> </desc> <listRelation> <relation name="UR1125" active="#struct-92114" type="direct"></relation> <relation active="#struct-301516" type="direct"></relation> <relation active="#struct-303171" type="direct"></relation> <relation name="U1153" active="#struct-303623" type="direct"></relation> </listRelation></org></tutelle><tutelle name="UR1125" active="#struct-92114" type="indirect"><org type="institution" xml:id="struct-92114" status="VALID"> <orgName>Institut National de la Recherche Agronomique</orgName> <orgName type="acronym">INRA</orgName> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.inra.fr</ref> </desc></org></tutelle><tutelle active="#struct-301516" type="indirect"><org type="institution" xml:id="struct-301516" status="VALID"> <orgName>CNAM</orgName> <desc> <address> <country key="FR"></country> </address> </desc></org></tutelle><tutelle active="#struct-303171" type="indirect"><org type="institution" xml:id="struct-303171" status="VALID"><orgName>Université Sorbonne Paris Cité</orgName><orgName type="acronym">USPC</orgName><desc><address><country key="FR"></country></address><ref type="url">http://www.sorbonne-paris-cite.fr/fr</ref></desc></org></tutelle><tutelle name="U1153" active="#struct-303623" type="indirect"><org type="institution" xml:id="struct-303623" status="VALID"><idno type="IdRef">026388278</idno><orgName>Institut National de la Santé et de la Recherche Médicale</orgName><orgName type="acronym">INSERM</orgName><desc><address><addrLine>101, rue de Tolbiac, 75013 Paris </addrLine><country key="FR"></country></address><ref type="url">http://www.inserm.fr</ref></desc></org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author></analytic><idno type="DOI">10.1001/jama.2016.13512</idno><series><title level="j">Journal of the American Medical Association</title><idno type="ISSN">0098-7484</idno><imprint><date type="datePub">2016-09-20</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader></TEI></HAL><PubMed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Non-TNF-Targeted Biologic vs a Second Anti-TNF Drug to Treat Rheumatoid Arthritis in Patients With Insufficient Response to a First Anti-TNF Drug: A Randomized Clinical Trial.</title><author><name sortKey="Gottenberg, Jacques Eric" sort="Gottenberg, Jacques Eric" uniqKey="Gottenberg J" first="Jacques-Eric" last="Gottenberg">Jacques-Eric Gottenberg</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, National Reference Center for Systemic Autoimmune Diseases, Strasbourg University Hospital, Université de Strasbourg, Strasbourg, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, National Reference Center for Systemic Autoimmune Diseases, Strasbourg University Hospital, Université de Strasbourg, Strasbourg</wicri:regionArea><placeName><settlement type="city">Strasbourg</settlement></placeName></affiliation></author><author><name sortKey="Brocq, Olivier" sort="Brocq, Olivier" uniqKey="Brocq O" first="Olivier" last="Brocq">Olivier Brocq</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Centre Hospitalier Princesse Grâce, Monaco.</nlm:affiliation><country xml:lang="fr">Monaco</country><wicri:regionArea>Department of Rheumatology, Centre Hospitalier Princesse Grâce</wicri:regionArea><wicri:noRegion>Centre Hospitalier Princesse Grâce</wicri:noRegion></affiliation></author><author><name sortKey="Perdriger, Aleth" sort="Perdriger, Aleth" uniqKey="Perdriger A" first="Aleth" last="Perdriger">Aleth Perdriger</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Rennes University Hospital, Rennes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Rennes University Hospital, Rennes</wicri:regionArea><placeName><settlement type="city">Rennes</settlement></placeName></affiliation></author><author><name sortKey="Lassoued, Slim" sort="Lassoued, Slim" uniqKey="Lassoued S" first="Slim" last="Lassoued">Slim Lassoued</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Centre Hospitalier de Cahors, Cahors, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Centre Hospitalier de Cahors, Cahors</wicri:regionArea><placeName><settlement type="city">Cahors</settlement></placeName></affiliation></author><author><name sortKey="Berthelot, Jean Marie" sort="Berthelot, Jean Marie" uniqKey="Berthelot J" first="Jean-Marie" last="Berthelot">Jean-Marie Berthelot</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Nantes University Hospital, Nantes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Nantes University Hospital, Nantes</wicri:regionArea><placeName><settlement type="city">Nantes</settlement></placeName></affiliation></author><author><name sortKey="Wendling, Daniel" sort="Wendling, Daniel" uniqKey="Wendling D" first="Daniel" last="Wendling">Daniel Wendling</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Besançon University Hospital, Besançon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Besançon University Hospital, Besançon</wicri:regionArea><placeName><settlement type="city">Besançon</settlement></placeName></affiliation></author><author><name sortKey="Euller Ziegler, Liana" sort="Euller Ziegler, Liana" uniqKey="Euller Ziegler L" first="Liana" last="Euller-Ziegler">Liana Euller-Ziegler</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Nice University Hospital, Nice, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Nice University Hospital, Nice</wicri:regionArea><placeName><settlement type="city">Nice</settlement></placeName></affiliation></author><author><name sortKey="Soubrier, Martin" sort="Soubrier, Martin" uniqKey="Soubrier M" first="Martin" last="Soubrier">Martin Soubrier</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Clermont-Ferrand University Hospital, Clermont-Ferrand, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Clermont-Ferrand University Hospital, Clermont-Ferrand</wicri:regionArea><placeName><settlement type="city">Clermont-Ferrand</settlement></placeName></affiliation></author><author><name sortKey="Richez, Christophe" sort="Richez, Christophe" uniqKey="Richez C" first="Christophe" last="Richez">Christophe Richez</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Bordeaux University Hospital, Bordeaux, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Bordeaux University Hospital, Bordeaux</wicri:regionArea><placeName><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Fautrel, Bruno" sort="Fautrel, Bruno" uniqKey="Fautrel B" first="Bruno" last="Fautrel">Bruno Fautrel</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Hôpital La Pitié Salpétrière, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Hôpital La Pitié Salpétrière, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Constantin, Arnaud L" sort="Constantin, Arnaud L" uniqKey="Constantin A" first="Arnaud L" last="Constantin">Arnaud L. Constantin</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Toulouse University Hospital, Toulouse, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Toulouse University Hospital, Toulouse</wicri:regionArea><placeName><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Mariette, Xavier" sort="Mariette, Xavier" uniqKey="Mariette X" first="Xavier" last="Mariette">Xavier Mariette</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Hôpital Kremlin Bicêtre, Kremlin Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Hôpital Kremlin Bicêtre, Kremlin Bicêtre</wicri:regionArea><wicri:noRegion>Kremlin Bicêtre</wicri:noRegion><wicri:noRegion>Kremlin Bicêtre</wicri:noRegion></affiliation></author><author><name sortKey="Morel, Jacques" sort="Morel, Jacques" uniqKey="Morel J" first="Jacques" last="Morel">Jacques Morel</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Montpellier University Hospital, Montpellier, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Montpellier University Hospital, Montpellier</wicri:regionArea><placeName><settlement type="city">Montpellier</settlement></placeName></affiliation></author><author><name sortKey="Gilson, Melanie" sort="Gilson, Melanie" uniqKey="Gilson M" first="Melanie" last="Gilson">Melanie Gilson</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Grenoble University Hospital, Grenoble, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Grenoble University Hospital, Grenoble</wicri:regionArea><placeName><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Cormier, Gregoire" sort="Cormier, Gregoire" uniqKey="Cormier G" first="Gregoire" last="Cormier">Gregoire Cormier</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Centre Hospitalier de La Roche Sur Yon, La Roche Sur Yon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Centre Hospitalier de La Roche Sur Yon, La Roche Sur Yon</wicri:regionArea><placeName><settlement type="city">La Roche-sur-Yon</settlement></placeName></affiliation></author><author><name sortKey="Salmon, Jean Hugues" sort="Salmon, Jean Hugues" uniqKey="Salmon J" first="Jean Hugues" last="Salmon">Jean Hugues Salmon</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Reims University Hospital, Reims, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Reims University Hospital, Reims</wicri:regionArea><placeName><settlement type="city">Reims</settlement></placeName></affiliation></author><author><name sortKey="Rist, Stephanie" sort="Rist, Stephanie" uniqKey="Rist S" first="Stephanie" last="Rist">Stephanie Rist</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Centre Hospitalier d'Orléans, Orléans, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Centre Hospitalier d'Orléans, Orléans</wicri:regionArea><placeName><settlement type="city">Orléans</settlement></placeName></affiliation></author><author><name sortKey="Liote, Frederic" sort="Liote, Frederic" uniqKey="Liote F" first="Frederic" last="Lioté">Frederic Lioté</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Hôpital Lariboisière, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Hôpital Lariboisière, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Marotte, Hubert" sort="Marotte, Hubert" uniqKey="Marotte H" first="Hubert" last="Marotte">Hubert Marotte</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Saint-Etienne University Hospital, Saint-Etienne, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Saint-Etienne University Hospital, Saint-Etienne</wicri:regionArea><placeName><settlement type="city">Saint-Étienne</settlement></placeName></affiliation></author><author><name sortKey="Bonnet, Christine" sort="Bonnet, Christine" uniqKey="Bonnet C" first="Christine" last="Bonnet">Christine Bonnet</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Limoges University Hospital, Limoges, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Limoges University Hospital, Limoges</wicri:regionArea><placeName><settlement type="city">Limoges</settlement></placeName></affiliation></author><author><name sortKey="Marcelli, Christian" sort="Marcelli, Christian" uniqKey="Marcelli C" first="Christian" last="Marcelli">Christian Marcelli</name><affiliation><nlm:affiliation>Department of Rheumatology, Caen University Hospital, Caen France.</nlm:affiliation><wicri:noCountry code="subField">Caen France</wicri:noCountry></affiliation></author><author><name sortKey="Sellam, Jeremie" sort="Sellam, Jeremie" uniqKey="Sellam J" first="Jeremie" last="Sellam">Jeremie Sellam</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Hôpital Saint-Antoine, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Hôpital Saint-Antoine, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Meyer, Olivier" sort="Meyer, Olivier" uniqKey="Meyer O" first="Olivier" last="Meyer">Olivier Meyer</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Hôpital Bichat, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Hôpital Bichat, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Solau Gervais, Elisabeth" sort="Solau Gervais, Elisabeth" uniqKey="Solau Gervais E" first="Elisabeth" last="Solau-Gervais">Elisabeth Solau-Gervais</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Poitiers University Hospital, Poitiers, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Poitiers University Hospital, Poitiers</wicri:regionArea><placeName><settlement type="city">Poitiers</settlement></placeName></affiliation></author><author><name sortKey="Guis, Sandrine" sort="Guis, Sandrine" uniqKey="Guis S" first="Sandrine" last="Guis">Sandrine Guis</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Marseille University Hospital, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Marseille University Hospital, Marseille</wicri:regionArea><placeName><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Ziza, Jean Marc" sort="Ziza, Jean Marc" uniqKey="Ziza J" first="Jean-Marc" last="Ziza">Jean-Marc Ziza</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Hôpital La Croix Saint Simon, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Hôpital La Croix Saint Simon, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Zarnitsky, Charles" sort="Zarnitsky, Charles" uniqKey="Zarnitsky C" first="Charles" last="Zarnitsky">Charles Zarnitsky</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Centre Hospitalier du Havre, Le Havre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Centre Hospitalier du Havre, Le Havre</wicri:regionArea><placeName><settlement type="city">Le Havre</settlement></placeName></affiliation></author><author><name sortKey="Chary Valckenaere, Isabelle" sort="Chary Valckenaere, Isabelle" uniqKey="Chary Valckenaere I" first="Isabelle" last="Chary-Valckenaere">Isabelle Chary-Valckenaere</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Nancy University Hospital, Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Nancy University Hospital, Nancy</wicri:regionArea><placeName><settlement type="city">Nancy</settlement></placeName></affiliation></author><author><name sortKey="Vittecoq, Olivier" sort="Vittecoq, Olivier" uniqKey="Vittecoq O" first="Olivier" last="Vittecoq">Olivier Vittecoq</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Rouen University Hospital, Rouen, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Rouen University Hospital, Rouen</wicri:regionArea><placeName><settlement type="city">Rouen</settlement></placeName></affiliation></author><author><name sortKey="Saraux, Alain" sort="Saraux, Alain" uniqKey="Saraux A" first="Alain" last="Saraux">Alain Saraux</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Brest University Hospital, Brest, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Brest University Hospital, Brest</wicri:regionArea><placeName><settlement type="city">Brest</settlement></placeName></affiliation></author><author><name sortKey="Pers, Yves Marie" sort="Pers, Yves Marie" uniqKey="Pers Y" first="Yves-Marie" last="Pers">Yves-Marie Pers</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Montpellier University Hospital, Montpellier, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Montpellier University Hospital, Montpellier</wicri:regionArea><placeName><settlement type="city">Montpellier</settlement></placeName></affiliation></author><author><name sortKey="Gayraud, Martine" sort="Gayraud, Martine" uniqKey="Gayraud M" first="Martine" last="Gayraud">Martine Gayraud</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine, Institut Montsouris, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Internal Medicine, Institut Montsouris, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Bolla, Gilles" sort="Bolla, Gilles" uniqKey="Bolla G" first="Gilles" last="Bolla">Gilles Bolla</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Centre Hospitalier de Cannes, Cannes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Centre Hospitalier de Cannes, Cannes</wicri:regionArea><wicri:noRegion>Cannes</wicri:noRegion><wicri:noRegion>Cannes</wicri:noRegion></affiliation></author><author><name sortKey="Claudepierre, Pascal" sort="Claudepierre, Pascal" uniqKey="Claudepierre P" first="Pascal" last="Claudepierre">Pascal Claudepierre</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Hôpital Mondor, Créteil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Hôpital Mondor, Créteil</wicri:regionArea><placeName><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="Ardizzone, Marc" sort="Ardizzone, Marc" uniqKey="Ardizzone M" first="Marc" last="Ardizzone">Marc Ardizzone</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Centre Hospitalier de Mulhouse, Mulhouse, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Centre Hospitalier de Mulhouse, Mulhouse</wicri:regionArea><placeName><settlement type="city">Mulhouse</settlement></placeName></affiliation></author><author><name sortKey="Dernis, Emmanuelle" sort="Dernis, Emmanuelle" uniqKey="Dernis E" first="Emmanuelle" last="Dernis">Emmanuelle Dernis</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Centre Hospitalier du Mans, Le Mans, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Centre Hospitalier du Mans, Le Mans</wicri:regionArea><placeName><settlement type="city">Le Mans</settlement></placeName></affiliation></author><author><name sortKey="Breban, Maxime A" sort="Breban, Maxime A" uniqKey="Breban M" first="Maxime A" last="Breban">Maxime A. Breban</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Hôpital Ambroise Paré, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Hôpital Ambroise Paré, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Fain, Olivier" sort="Fain, Olivier" uniqKey="Fain O" first="Olivier" last="Fain">Olivier Fain</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine, Hôpital Saint-Antoine, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Internal Medicine, Hôpital Saint-Antoine, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Balblanc, Jean Charles" sort="Balblanc, Jean Charles" uniqKey="Balblanc J" first="Jean-Charles" last="Balblanc">Jean-Charles Balblanc</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Centre Hospitalier de Belfort, Belfort, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Centre Hospitalier de Belfort, Belfort</wicri:regionArea><placeName><settlement type="city">Belfort</settlement></placeName></affiliation></author><author><name sortKey="Aberkane, Ouafaa" sort="Aberkane, Ouafaa" uniqKey="Aberkane O" first="Ouafaa" last="Aberkane">Ouafaa Aberkane</name><affiliation wicri:level="1"><nlm:affiliation>Department of Direction de la recherche clinique et de l'innovation, Strasbourg University Hospital, Strasbourg, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Direction de la recherche clinique et de l'innovation, Strasbourg University Hospital, Strasbourg</wicri:regionArea><placeName><settlement type="city">Strasbourg</settlement></placeName></affiliation></author><author><name sortKey="Vazel, Marion" sort="Vazel, Marion" uniqKey="Vazel M" first="Marion" last="Vazel">Marion Vazel</name><affiliation wicri:level="1"><nlm:affiliation>Department of Direction de la recherche clinique et de l'innovation, Strasbourg University Hospital, Strasbourg, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Direction de la recherche clinique et de l'innovation, Strasbourg University Hospital, Strasbourg</wicri:regionArea><placeName><settlement type="city">Strasbourg</settlement></placeName></affiliation></author><author><name sortKey="Back, Christelle" sort="Back, Christelle" uniqKey="Back C" first="Christelle" last="Back">Christelle Back</name><affiliation wicri:level="1"><nlm:affiliation>Department of Direction de la recherche clinique et de l'innovation, Strasbourg University Hospital, Strasbourg, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Direction de la recherche clinique et de l'innovation, Strasbourg University Hospital, Strasbourg</wicri:regionArea><placeName><settlement type="city">Strasbourg</settlement></placeName></affiliation></author><author><name sortKey="Candon, Sophie" sort="Candon, Sophie" uniqKey="Candon S" first="Sophie" last="Candon">Sophie Candon</name><affiliation wicri:level="1"><nlm:affiliation>Department of Immunology, Hôpital Necker, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Immunology, Hôpital Necker, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Chatenoud, Lucienne" sort="Chatenoud, Lucienne" uniqKey="Chatenoud L" first="Lucienne" last="Chatenoud">Lucienne Chatenoud</name><affiliation wicri:level="1"><nlm:affiliation>Department of Immunology, Hôpital Necker, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Immunology, Hôpital Necker, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Perrodeau, Elodie" sort="Perrodeau, Elodie" uniqKey="Perrodeau E" first="Elodie" last="Perrodeau">Elodie Perrodeau</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology and Biostatistics, Hotel Dieu, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Epidemiology and Biostatistics, Hotel Dieu, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Sibilia, Jean" sort="Sibilia, Jean" uniqKey="Sibilia J" first="Jean" last="Sibilia">Jean Sibilia</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, National Reference Center for Systemic Autoimmune Diseases, Strasbourg University Hospital, Université de Strasbourg, Strasbourg, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, National Reference Center for Systemic Autoimmune Diseases, Strasbourg University Hospital, Université de Strasbourg, Strasbourg</wicri:regionArea><placeName><settlement type="city">Strasbourg</settlement></placeName></affiliation></author><author><name sortKey="Ravaud, Philippe" sort="Ravaud, Philippe" uniqKey="Ravaud P" first="Philippe" last="Ravaud">Philippe Ravaud</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology and Biostatistics, Hotel Dieu, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Epidemiology and Biostatistics, Hotel Dieu, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27654603</idno><idno type="pmid">27654603</idno><idno type="doi">10.1001/jama.2016.13512</idno><idno type="wicri:Area/PubMed/Corpus">000013</idno><idno type="wicri:Area/PubMed/Curation">000013</idno><idno type="wicri:Area/PubMed/Checkpoint">000013</idno><idno type="wicri:Area/Ncbi/Merge">000567</idno><idno type="wicri:Area/Ncbi/Curation">000567</idno><idno type="wicri:Area/Ncbi/Checkpoint">000567</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Non-TNF-Targeted Biologic vs a Second Anti-TNF Drug to Treat Rheumatoid Arthritis in Patients With Insufficient Response to a First Anti-TNF Drug: A Randomized Clinical Trial.</title><author><name sortKey="Gottenberg, Jacques Eric" sort="Gottenberg, Jacques Eric" uniqKey="Gottenberg J" first="Jacques-Eric" last="Gottenberg">Jacques-Eric Gottenberg</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, National Reference Center for Systemic Autoimmune Diseases, Strasbourg University Hospital, Université de Strasbourg, Strasbourg, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, National Reference Center for Systemic Autoimmune Diseases, Strasbourg University Hospital, Université de Strasbourg, Strasbourg</wicri:regionArea><placeName><settlement type="city">Strasbourg</settlement></placeName></affiliation></author><author><name sortKey="Brocq, Olivier" sort="Brocq, Olivier" uniqKey="Brocq O" first="Olivier" last="Brocq">Olivier Brocq</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Centre Hospitalier Princesse Grâce, Monaco.</nlm:affiliation><country xml:lang="fr">Monaco</country><wicri:regionArea>Department of Rheumatology, Centre Hospitalier Princesse Grâce</wicri:regionArea><wicri:noRegion>Centre Hospitalier Princesse Grâce</wicri:noRegion></affiliation></author><author><name sortKey="Perdriger, Aleth" sort="Perdriger, Aleth" uniqKey="Perdriger A" first="Aleth" last="Perdriger">Aleth Perdriger</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Rennes University Hospital, Rennes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Rennes University Hospital, Rennes</wicri:regionArea><placeName><settlement type="city">Rennes</settlement></placeName></affiliation></author><author><name sortKey="Lassoued, Slim" sort="Lassoued, Slim" uniqKey="Lassoued S" first="Slim" last="Lassoued">Slim Lassoued</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Centre Hospitalier de Cahors, Cahors, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Centre Hospitalier de Cahors, Cahors</wicri:regionArea><placeName><settlement type="city">Cahors</settlement></placeName></affiliation></author><author><name sortKey="Berthelot, Jean Marie" sort="Berthelot, Jean Marie" uniqKey="Berthelot J" first="Jean-Marie" last="Berthelot">Jean-Marie Berthelot</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Nantes University Hospital, Nantes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Nantes University Hospital, Nantes</wicri:regionArea><placeName><settlement type="city">Nantes</settlement></placeName></affiliation></author><author><name sortKey="Wendling, Daniel" sort="Wendling, Daniel" uniqKey="Wendling D" first="Daniel" last="Wendling">Daniel Wendling</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Besançon University Hospital, Besançon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Besançon University Hospital, Besançon</wicri:regionArea><placeName><settlement type="city">Besançon</settlement></placeName></affiliation></author><author><name sortKey="Euller Ziegler, Liana" sort="Euller Ziegler, Liana" uniqKey="Euller Ziegler L" first="Liana" last="Euller-Ziegler">Liana Euller-Ziegler</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Nice University Hospital, Nice, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Nice University Hospital, Nice</wicri:regionArea><placeName><settlement type="city">Nice</settlement></placeName></affiliation></author><author><name sortKey="Soubrier, Martin" sort="Soubrier, Martin" uniqKey="Soubrier M" first="Martin" last="Soubrier">Martin Soubrier</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Clermont-Ferrand University Hospital, Clermont-Ferrand, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Clermont-Ferrand University Hospital, Clermont-Ferrand</wicri:regionArea><placeName><settlement type="city">Clermont-Ferrand</settlement></placeName></affiliation></author><author><name sortKey="Richez, Christophe" sort="Richez, Christophe" uniqKey="Richez C" first="Christophe" last="Richez">Christophe Richez</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Bordeaux University Hospital, Bordeaux, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Bordeaux University Hospital, Bordeaux</wicri:regionArea><placeName><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Fautrel, Bruno" sort="Fautrel, Bruno" uniqKey="Fautrel B" first="Bruno" last="Fautrel">Bruno Fautrel</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Hôpital La Pitié Salpétrière, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Hôpital La Pitié Salpétrière, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Constantin, Arnaud L" sort="Constantin, Arnaud L" uniqKey="Constantin A" first="Arnaud L" last="Constantin">Arnaud L. Constantin</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Toulouse University Hospital, Toulouse, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Toulouse University Hospital, Toulouse</wicri:regionArea><placeName><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Mariette, Xavier" sort="Mariette, Xavier" uniqKey="Mariette X" first="Xavier" last="Mariette">Xavier Mariette</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Hôpital Kremlin Bicêtre, Kremlin Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Hôpital Kremlin Bicêtre, Kremlin Bicêtre</wicri:regionArea><wicri:noRegion>Kremlin Bicêtre</wicri:noRegion><wicri:noRegion>Kremlin Bicêtre</wicri:noRegion></affiliation></author><author><name sortKey="Morel, Jacques" sort="Morel, Jacques" uniqKey="Morel J" first="Jacques" last="Morel">Jacques Morel</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Montpellier University Hospital, Montpellier, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Montpellier University Hospital, Montpellier</wicri:regionArea><placeName><settlement type="city">Montpellier</settlement></placeName></affiliation></author><author><name sortKey="Gilson, Melanie" sort="Gilson, Melanie" uniqKey="Gilson M" first="Melanie" last="Gilson">Melanie Gilson</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Grenoble University Hospital, Grenoble, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Grenoble University Hospital, Grenoble</wicri:regionArea><placeName><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Cormier, Gregoire" sort="Cormier, Gregoire" uniqKey="Cormier G" first="Gregoire" last="Cormier">Gregoire Cormier</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Centre Hospitalier de La Roche Sur Yon, La Roche Sur Yon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Centre Hospitalier de La Roche Sur Yon, La Roche Sur Yon</wicri:regionArea><placeName><settlement type="city">La Roche-sur-Yon</settlement></placeName></affiliation></author><author><name sortKey="Salmon, Jean Hugues" sort="Salmon, Jean Hugues" uniqKey="Salmon J" first="Jean Hugues" last="Salmon">Jean Hugues Salmon</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Reims University Hospital, Reims, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Reims University Hospital, Reims</wicri:regionArea><placeName><settlement type="city">Reims</settlement></placeName></affiliation></author><author><name sortKey="Rist, Stephanie" sort="Rist, Stephanie" uniqKey="Rist S" first="Stephanie" last="Rist">Stephanie Rist</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Centre Hospitalier d'Orléans, Orléans, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Centre Hospitalier d'Orléans, Orléans</wicri:regionArea><placeName><settlement type="city">Orléans</settlement></placeName></affiliation></author><author><name sortKey="Liote, Frederic" sort="Liote, Frederic" uniqKey="Liote F" first="Frederic" last="Lioté">Frederic Lioté</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Hôpital Lariboisière, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Hôpital Lariboisière, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Marotte, Hubert" sort="Marotte, Hubert" uniqKey="Marotte H" first="Hubert" last="Marotte">Hubert Marotte</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Saint-Etienne University Hospital, Saint-Etienne, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Saint-Etienne University Hospital, Saint-Etienne</wicri:regionArea><placeName><settlement type="city">Saint-Étienne</settlement></placeName></affiliation></author><author><name sortKey="Bonnet, Christine" sort="Bonnet, Christine" uniqKey="Bonnet C" first="Christine" last="Bonnet">Christine Bonnet</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Limoges University Hospital, Limoges, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Limoges University Hospital, Limoges</wicri:regionArea><placeName><settlement type="city">Limoges</settlement></placeName></affiliation></author><author><name sortKey="Marcelli, Christian" sort="Marcelli, Christian" uniqKey="Marcelli C" first="Christian" last="Marcelli">Christian Marcelli</name><affiliation><nlm:affiliation>Department of Rheumatology, Caen University Hospital, Caen France.</nlm:affiliation><wicri:noCountry code="subField">Caen France</wicri:noCountry></affiliation></author><author><name sortKey="Sellam, Jeremie" sort="Sellam, Jeremie" uniqKey="Sellam J" first="Jeremie" last="Sellam">Jeremie Sellam</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Hôpital Saint-Antoine, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Hôpital Saint-Antoine, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Meyer, Olivier" sort="Meyer, Olivier" uniqKey="Meyer O" first="Olivier" last="Meyer">Olivier Meyer</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Hôpital Bichat, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Hôpital Bichat, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Solau Gervais, Elisabeth" sort="Solau Gervais, Elisabeth" uniqKey="Solau Gervais E" first="Elisabeth" last="Solau-Gervais">Elisabeth Solau-Gervais</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Poitiers University Hospital, Poitiers, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Poitiers University Hospital, Poitiers</wicri:regionArea><placeName><settlement type="city">Poitiers</settlement></placeName></affiliation></author><author><name sortKey="Guis, Sandrine" sort="Guis, Sandrine" uniqKey="Guis S" first="Sandrine" last="Guis">Sandrine Guis</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Marseille University Hospital, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Marseille University Hospital, Marseille</wicri:regionArea><placeName><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Ziza, Jean Marc" sort="Ziza, Jean Marc" uniqKey="Ziza J" first="Jean-Marc" last="Ziza">Jean-Marc Ziza</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Hôpital La Croix Saint Simon, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Hôpital La Croix Saint Simon, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Zarnitsky, Charles" sort="Zarnitsky, Charles" uniqKey="Zarnitsky C" first="Charles" last="Zarnitsky">Charles Zarnitsky</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Centre Hospitalier du Havre, Le Havre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Centre Hospitalier du Havre, Le Havre</wicri:regionArea><placeName><settlement type="city">Le Havre</settlement></placeName></affiliation></author><author><name sortKey="Chary Valckenaere, Isabelle" sort="Chary Valckenaere, Isabelle" uniqKey="Chary Valckenaere I" first="Isabelle" last="Chary-Valckenaere">Isabelle Chary-Valckenaere</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Nancy University Hospital, Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Nancy University Hospital, Nancy</wicri:regionArea><placeName><settlement type="city">Nancy</settlement></placeName></affiliation></author><author><name sortKey="Vittecoq, Olivier" sort="Vittecoq, Olivier" uniqKey="Vittecoq O" first="Olivier" last="Vittecoq">Olivier Vittecoq</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Rouen University Hospital, Rouen, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Rouen University Hospital, Rouen</wicri:regionArea><placeName><settlement type="city">Rouen</settlement></placeName></affiliation></author><author><name sortKey="Saraux, Alain" sort="Saraux, Alain" uniqKey="Saraux A" first="Alain" last="Saraux">Alain Saraux</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Brest University Hospital, Brest, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Brest University Hospital, Brest</wicri:regionArea><placeName><settlement type="city">Brest</settlement></placeName></affiliation></author><author><name sortKey="Pers, Yves Marie" sort="Pers, Yves Marie" uniqKey="Pers Y" first="Yves-Marie" last="Pers">Yves-Marie Pers</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Montpellier University Hospital, Montpellier, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Montpellier University Hospital, Montpellier</wicri:regionArea><placeName><settlement type="city">Montpellier</settlement></placeName></affiliation></author><author><name sortKey="Gayraud, Martine" sort="Gayraud, Martine" uniqKey="Gayraud M" first="Martine" last="Gayraud">Martine Gayraud</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine, Institut Montsouris, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Internal Medicine, Institut Montsouris, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Bolla, Gilles" sort="Bolla, Gilles" uniqKey="Bolla G" first="Gilles" last="Bolla">Gilles Bolla</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Centre Hospitalier de Cannes, Cannes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Centre Hospitalier de Cannes, Cannes</wicri:regionArea><wicri:noRegion>Cannes</wicri:noRegion><wicri:noRegion>Cannes</wicri:noRegion></affiliation></author><author><name sortKey="Claudepierre, Pascal" sort="Claudepierre, Pascal" uniqKey="Claudepierre P" first="Pascal" last="Claudepierre">Pascal Claudepierre</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Hôpital Mondor, Créteil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Hôpital Mondor, Créteil</wicri:regionArea><placeName><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="Ardizzone, Marc" sort="Ardizzone, Marc" uniqKey="Ardizzone M" first="Marc" last="Ardizzone">Marc Ardizzone</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Centre Hospitalier de Mulhouse, Mulhouse, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Centre Hospitalier de Mulhouse, Mulhouse</wicri:regionArea><placeName><settlement type="city">Mulhouse</settlement></placeName></affiliation></author><author><name sortKey="Dernis, Emmanuelle" sort="Dernis, Emmanuelle" uniqKey="Dernis E" first="Emmanuelle" last="Dernis">Emmanuelle Dernis</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Centre Hospitalier du Mans, Le Mans, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Centre Hospitalier du Mans, Le Mans</wicri:regionArea><placeName><settlement type="city">Le Mans</settlement></placeName></affiliation></author><author><name sortKey="Breban, Maxime A" sort="Breban, Maxime A" uniqKey="Breban M" first="Maxime A" last="Breban">Maxime A. Breban</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Hôpital Ambroise Paré, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Hôpital Ambroise Paré, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Fain, Olivier" sort="Fain, Olivier" uniqKey="Fain O" first="Olivier" last="Fain">Olivier Fain</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine, Hôpital Saint-Antoine, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Internal Medicine, Hôpital Saint-Antoine, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Balblanc, Jean Charles" sort="Balblanc, Jean Charles" uniqKey="Balblanc J" first="Jean-Charles" last="Balblanc">Jean-Charles Balblanc</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Centre Hospitalier de Belfort, Belfort, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Centre Hospitalier de Belfort, Belfort</wicri:regionArea><placeName><settlement type="city">Belfort</settlement></placeName></affiliation></author><author><name sortKey="Aberkane, Ouafaa" sort="Aberkane, Ouafaa" uniqKey="Aberkane O" first="Ouafaa" last="Aberkane">Ouafaa Aberkane</name><affiliation wicri:level="1"><nlm:affiliation>Department of Direction de la recherche clinique et de l'innovation, Strasbourg University Hospital, Strasbourg, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Direction de la recherche clinique et de l'innovation, Strasbourg University Hospital, Strasbourg</wicri:regionArea><placeName><settlement type="city">Strasbourg</settlement></placeName></affiliation></author><author><name sortKey="Vazel, Marion" sort="Vazel, Marion" uniqKey="Vazel M" first="Marion" last="Vazel">Marion Vazel</name><affiliation wicri:level="1"><nlm:affiliation>Department of Direction de la recherche clinique et de l'innovation, Strasbourg University Hospital, Strasbourg, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Direction de la recherche clinique et de l'innovation, Strasbourg University Hospital, Strasbourg</wicri:regionArea><placeName><settlement type="city">Strasbourg</settlement></placeName></affiliation></author><author><name sortKey="Back, Christelle" sort="Back, Christelle" uniqKey="Back C" first="Christelle" last="Back">Christelle Back</name><affiliation wicri:level="1"><nlm:affiliation>Department of Direction de la recherche clinique et de l'innovation, Strasbourg University Hospital, Strasbourg, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Direction de la recherche clinique et de l'innovation, Strasbourg University Hospital, Strasbourg</wicri:regionArea><placeName><settlement type="city">Strasbourg</settlement></placeName></affiliation></author><author><name sortKey="Candon, Sophie" sort="Candon, Sophie" uniqKey="Candon S" first="Sophie" last="Candon">Sophie Candon</name><affiliation wicri:level="1"><nlm:affiliation>Department of Immunology, Hôpital Necker, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Immunology, Hôpital Necker, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Chatenoud, Lucienne" sort="Chatenoud, Lucienne" uniqKey="Chatenoud L" first="Lucienne" last="Chatenoud">Lucienne Chatenoud</name><affiliation wicri:level="1"><nlm:affiliation>Department of Immunology, Hôpital Necker, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Immunology, Hôpital Necker, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Perrodeau, Elodie" sort="Perrodeau, Elodie" uniqKey="Perrodeau E" first="Elodie" last="Perrodeau">Elodie Perrodeau</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology and Biostatistics, Hotel Dieu, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Epidemiology and Biostatistics, Hotel Dieu, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Sibilia, Jean" sort="Sibilia, Jean" uniqKey="Sibilia J" first="Jean" last="Sibilia">Jean Sibilia</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, National Reference Center for Systemic Autoimmune Diseases, Strasbourg University Hospital, Université de Strasbourg, Strasbourg, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, National Reference Center for Systemic Autoimmune Diseases, Strasbourg University Hospital, Université de Strasbourg, Strasbourg</wicri:regionArea><placeName><settlement type="city">Strasbourg</settlement></placeName></affiliation></author><author><name sortKey="Ravaud, Philippe" sort="Ravaud, Philippe" uniqKey="Ravaud P" first="Philippe" last="Ravaud">Philippe Ravaud</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology and Biostatistics, Hotel Dieu, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Epidemiology and Biostatistics, Hotel Dieu, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author></analytic><series><title level="j">JAMA</title><idno type="eISSN">1538-3598</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">One-third of patients with rheumatoid arthritis show inadequate response to tumor necrosis factor α (TNF-α) inhibitors; little guidance on choosing the next treatment exists.</div></front></TEI></PubMed></double></record>Pour manipuler ce document sous Unix (Dilib)
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|texte= Non-TNF-Targeted Biologic vs a Second Anti-TNF Drug to Treat Rheumatoid Arthritis in Patients With Insufficient Response to a First Anti-TNF Drug: A Randomized Clinical Trial.
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