Non-TNF-Targeted Biologic vs a Second Anti-TNF Drug to Treat Rheumatoid Arthritis in Patients With Insufficient Response to a First Anti-TNF Drug: A Randomized Clinical Trial.
Identifieur interne : 000013 ( PubMed/Corpus ); précédent : 000012; suivant : 000014Non-TNF-Targeted Biologic vs a Second Anti-TNF Drug to Treat Rheumatoid Arthritis in Patients With Insufficient Response to a First Anti-TNF Drug: A Randomized Clinical Trial.
Auteurs : Jacques-Eric Gottenberg ; Olivier Brocq ; Aleth Perdriger ; Slim Lassoued ; Jean-Marie Berthelot ; Daniel Wendling ; Liana Euller-Ziegler ; Martin Soubrier ; Christophe Richez ; Bruno Fautrel ; Arnaud L. Constantin ; Xavier Mariette ; Jacques Morel ; Melanie Gilson ; Gregoire Cormier ; Jean Hugues Salmon ; Stephanie Rist ; Frederic Lioté ; Hubert Marotte ; Christine Bonnet ; Christian Marcelli ; Jeremie Sellam ; Olivier Meyer ; Elisabeth Solau-Gervais ; Sandrine Guis ; Jean-Marc Ziza ; Charles Zarnitsky ; Isabelle Chary-Valckenaere ; Olivier Vittecoq ; Alain Saraux ; Yves-Marie Pers ; Martine Gayraud ; Gilles Bolla ; Pascal Claudepierre ; Marc Ardizzone ; Emmanuelle Dernis ; Maxime A. Breban ; Olivier Fain ; Jean-Charles Balblanc ; Ouafaa Aberkane ; Marion Vazel ; Christelle Back ; Sophie Candon ; Lucienne Chatenoud ; Elodie Perrodeau ; Jean Sibilia ; Philippe RavaudSource :
- JAMA [ 1538-3598 ] ; 2016.
Abstract
One-third of patients with rheumatoid arthritis show inadequate response to tumor necrosis factor α (TNF-α) inhibitors; little guidance on choosing the next treatment exists.
DOI: 10.1001/jama.2016.13512
PubMed: 27654603
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Non-TNF-Targeted Biologic vs a Second Anti-TNF Drug to Treat Rheumatoid Arthritis in Patients With Insufficient Response to a First Anti-TNF Drug: A Randomized Clinical Trial.</title><author><name sortKey="Gottenberg, Jacques Eric" sort="Gottenberg, Jacques Eric" uniqKey="Gottenberg J" first="Jacques-Eric" last="Gottenberg">Jacques-Eric Gottenberg</name><affiliation><nlm:affiliation>Department of Rheumatology, National Reference Center for Systemic Autoimmune Diseases, Strasbourg University Hospital, Université de Strasbourg, Strasbourg, France.</nlm:affiliation></affiliation></author><author><name sortKey="Brocq, Olivier" sort="Brocq, Olivier" uniqKey="Brocq O" first="Olivier" last="Brocq">Olivier Brocq</name><affiliation><nlm:affiliation>Department of Rheumatology, Centre Hospitalier Princesse Grâce, Monaco.</nlm:affiliation></affiliation></author><author><name sortKey="Perdriger, Aleth" sort="Perdriger, Aleth" uniqKey="Perdriger A" first="Aleth" last="Perdriger">Aleth Perdriger</name><affiliation><nlm:affiliation>Department of Rheumatology, Rennes University Hospital, Rennes, France.</nlm:affiliation></affiliation></author><author><name sortKey="Lassoued, Slim" sort="Lassoued, Slim" uniqKey="Lassoued S" first="Slim" last="Lassoued">Slim Lassoued</name><affiliation><nlm:affiliation>Department of Rheumatology, Centre Hospitalier de Cahors, Cahors, France.</nlm:affiliation></affiliation></author><author><name sortKey="Berthelot, Jean Marie" sort="Berthelot, Jean Marie" uniqKey="Berthelot J" first="Jean-Marie" last="Berthelot">Jean-Marie Berthelot</name><affiliation><nlm:affiliation>Department of Rheumatology, Nantes University Hospital, Nantes, France.</nlm:affiliation></affiliation></author><author><name sortKey="Wendling, Daniel" sort="Wendling, Daniel" uniqKey="Wendling D" first="Daniel" last="Wendling">Daniel Wendling</name><affiliation><nlm:affiliation>Department of Rheumatology, Besançon University Hospital, Besançon, France.</nlm:affiliation></affiliation></author><author><name sortKey="Euller Ziegler, Liana" sort="Euller Ziegler, Liana" uniqKey="Euller Ziegler L" first="Liana" last="Euller-Ziegler">Liana Euller-Ziegler</name><affiliation><nlm:affiliation>Department of Rheumatology, Nice University Hospital, Nice, France.</nlm:affiliation></affiliation></author><author><name sortKey="Soubrier, Martin" sort="Soubrier, Martin" uniqKey="Soubrier M" first="Martin" last="Soubrier">Martin Soubrier</name><affiliation><nlm:affiliation>Department of Rheumatology, Clermont-Ferrand University Hospital, Clermont-Ferrand, France.</nlm:affiliation></affiliation></author><author><name sortKey="Richez, Christophe" sort="Richez, Christophe" uniqKey="Richez C" first="Christophe" last="Richez">Christophe Richez</name><affiliation><nlm:affiliation>Department of Rheumatology, Bordeaux University Hospital, Bordeaux, France.</nlm:affiliation></affiliation></author><author><name sortKey="Fautrel, Bruno" sort="Fautrel, Bruno" uniqKey="Fautrel B" first="Bruno" last="Fautrel">Bruno Fautrel</name><affiliation><nlm:affiliation>Department of Rheumatology, Hôpital La Pitié Salpétrière, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Constantin, Arnaud L" sort="Constantin, Arnaud L" uniqKey="Constantin A" first="Arnaud L" last="Constantin">Arnaud L. Constantin</name><affiliation><nlm:affiliation>Department of Rheumatology, Toulouse University Hospital, Toulouse, France.</nlm:affiliation></affiliation></author><author><name sortKey="Mariette, Xavier" sort="Mariette, Xavier" uniqKey="Mariette X" first="Xavier" last="Mariette">Xavier Mariette</name><affiliation><nlm:affiliation>Department of Rheumatology, Hôpital Kremlin Bicêtre, Kremlin Bicêtre, France.</nlm:affiliation></affiliation></author><author><name sortKey="Morel, Jacques" sort="Morel, Jacques" uniqKey="Morel J" first="Jacques" last="Morel">Jacques Morel</name><affiliation><nlm:affiliation>Department of Rheumatology, Montpellier University Hospital, Montpellier, France.</nlm:affiliation></affiliation></author><author><name sortKey="Gilson, Melanie" sort="Gilson, Melanie" uniqKey="Gilson M" first="Melanie" last="Gilson">Melanie Gilson</name><affiliation><nlm:affiliation>Department of Rheumatology, Grenoble University Hospital, Grenoble, France.</nlm:affiliation></affiliation></author><author><name sortKey="Cormier, Gregoire" sort="Cormier, Gregoire" uniqKey="Cormier G" first="Gregoire" last="Cormier">Gregoire Cormier</name><affiliation><nlm:affiliation>Department of Rheumatology, Centre Hospitalier de La Roche Sur Yon, La Roche Sur Yon, France.</nlm:affiliation></affiliation></author><author><name sortKey="Salmon, Jean Hugues" sort="Salmon, Jean Hugues" uniqKey="Salmon J" first="Jean Hugues" last="Salmon">Jean Hugues Salmon</name><affiliation><nlm:affiliation>Department of Rheumatology, Reims University Hospital, Reims, France.</nlm:affiliation></affiliation></author><author><name sortKey="Rist, Stephanie" sort="Rist, Stephanie" uniqKey="Rist S" first="Stephanie" last="Rist">Stephanie Rist</name><affiliation><nlm:affiliation>Department of Rheumatology, Centre Hospitalier d'Orléans, Orléans, France.</nlm:affiliation></affiliation></author><author><name sortKey="Liote, Frederic" sort="Liote, Frederic" uniqKey="Liote F" first="Frederic" last="Lioté">Frederic Lioté</name><affiliation><nlm:affiliation>Department of Rheumatology, Hôpital Lariboisière, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Marotte, Hubert" sort="Marotte, Hubert" uniqKey="Marotte H" first="Hubert" last="Marotte">Hubert Marotte</name><affiliation><nlm:affiliation>Department of Rheumatology, Saint-Etienne University Hospital, Saint-Etienne, France.</nlm:affiliation></affiliation></author><author><name sortKey="Bonnet, Christine" sort="Bonnet, Christine" uniqKey="Bonnet C" first="Christine" last="Bonnet">Christine Bonnet</name><affiliation><nlm:affiliation>Department of Rheumatology, Limoges University Hospital, Limoges, France.</nlm:affiliation></affiliation></author><author><name sortKey="Marcelli, Christian" sort="Marcelli, Christian" uniqKey="Marcelli C" first="Christian" last="Marcelli">Christian Marcelli</name><affiliation><nlm:affiliation>Department of Rheumatology, Caen University Hospital, Caen France.</nlm:affiliation></affiliation></author><author><name sortKey="Sellam, Jeremie" sort="Sellam, Jeremie" uniqKey="Sellam J" first="Jeremie" last="Sellam">Jeremie Sellam</name><affiliation><nlm:affiliation>Department of Rheumatology, Hôpital Saint-Antoine, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Meyer, Olivier" sort="Meyer, Olivier" uniqKey="Meyer O" first="Olivier" last="Meyer">Olivier Meyer</name><affiliation><nlm:affiliation>Department of Rheumatology, Hôpital Bichat, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Solau Gervais, Elisabeth" sort="Solau Gervais, Elisabeth" uniqKey="Solau Gervais E" first="Elisabeth" last="Solau-Gervais">Elisabeth Solau-Gervais</name><affiliation><nlm:affiliation>Department of Rheumatology, Poitiers University Hospital, Poitiers, France.</nlm:affiliation></affiliation></author><author><name sortKey="Guis, Sandrine" sort="Guis, Sandrine" uniqKey="Guis S" first="Sandrine" last="Guis">Sandrine Guis</name><affiliation><nlm:affiliation>Department of Rheumatology, Marseille University Hospital, Marseille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Ziza, Jean Marc" sort="Ziza, Jean Marc" uniqKey="Ziza J" first="Jean-Marc" last="Ziza">Jean-Marc Ziza</name><affiliation><nlm:affiliation>Department of Rheumatology, Hôpital La Croix Saint Simon, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Zarnitsky, Charles" sort="Zarnitsky, Charles" uniqKey="Zarnitsky C" first="Charles" last="Zarnitsky">Charles Zarnitsky</name><affiliation><nlm:affiliation>Department of Rheumatology, Centre Hospitalier du Havre, Le Havre, France.</nlm:affiliation></affiliation></author><author><name sortKey="Chary Valckenaere, Isabelle" sort="Chary Valckenaere, Isabelle" uniqKey="Chary Valckenaere I" first="Isabelle" last="Chary-Valckenaere">Isabelle Chary-Valckenaere</name><affiliation><nlm:affiliation>Department of Rheumatology, Nancy University Hospital, Nancy, France.</nlm:affiliation></affiliation></author><author><name sortKey="Vittecoq, Olivier" sort="Vittecoq, Olivier" uniqKey="Vittecoq O" first="Olivier" last="Vittecoq">Olivier Vittecoq</name><affiliation><nlm:affiliation>Department of Rheumatology, Rouen University Hospital, Rouen, France.</nlm:affiliation></affiliation></author><author><name sortKey="Saraux, Alain" sort="Saraux, Alain" uniqKey="Saraux A" first="Alain" last="Saraux">Alain Saraux</name><affiliation><nlm:affiliation>Department of Rheumatology, Brest University Hospital, Brest, France.</nlm:affiliation></affiliation></author><author><name sortKey="Pers, Yves Marie" sort="Pers, Yves Marie" uniqKey="Pers Y" first="Yves-Marie" last="Pers">Yves-Marie Pers</name><affiliation><nlm:affiliation>Department of Rheumatology, Montpellier University Hospital, Montpellier, France.</nlm:affiliation></affiliation></author><author><name sortKey="Gayraud, Martine" sort="Gayraud, Martine" uniqKey="Gayraud M" first="Martine" last="Gayraud">Martine Gayraud</name><affiliation><nlm:affiliation>Department of Internal Medicine, Institut Montsouris, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Bolla, Gilles" sort="Bolla, Gilles" uniqKey="Bolla G" first="Gilles" last="Bolla">Gilles Bolla</name><affiliation><nlm:affiliation>Department of Rheumatology, Centre Hospitalier de Cannes, Cannes, France.</nlm:affiliation></affiliation></author><author><name sortKey="Claudepierre, Pascal" sort="Claudepierre, Pascal" uniqKey="Claudepierre P" first="Pascal" last="Claudepierre">Pascal Claudepierre</name><affiliation><nlm:affiliation>Department of Rheumatology, Hôpital Mondor, Créteil, France.</nlm:affiliation></affiliation></author><author><name sortKey="Ardizzone, Marc" sort="Ardizzone, Marc" uniqKey="Ardizzone M" first="Marc" last="Ardizzone">Marc Ardizzone</name><affiliation><nlm:affiliation>Department of Rheumatology, Centre Hospitalier de Mulhouse, Mulhouse, France.</nlm:affiliation></affiliation></author><author><name sortKey="Dernis, Emmanuelle" sort="Dernis, Emmanuelle" uniqKey="Dernis E" first="Emmanuelle" last="Dernis">Emmanuelle Dernis</name><affiliation><nlm:affiliation>Department of Rheumatology, Centre Hospitalier du Mans, Le Mans, France.</nlm:affiliation></affiliation></author><author><name sortKey="Breban, Maxime A" sort="Breban, Maxime A" uniqKey="Breban M" first="Maxime A" last="Breban">Maxime A. Breban</name><affiliation><nlm:affiliation>Department of Rheumatology, Hôpital Ambroise Paré, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Fain, Olivier" sort="Fain, Olivier" uniqKey="Fain O" first="Olivier" last="Fain">Olivier Fain</name><affiliation><nlm:affiliation>Department of Internal Medicine, Hôpital Saint-Antoine, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Balblanc, Jean Charles" sort="Balblanc, Jean Charles" uniqKey="Balblanc J" first="Jean-Charles" last="Balblanc">Jean-Charles Balblanc</name><affiliation><nlm:affiliation>Department of Rheumatology, Centre Hospitalier de Belfort, Belfort, France.</nlm:affiliation></affiliation></author><author><name sortKey="Aberkane, Ouafaa" sort="Aberkane, Ouafaa" uniqKey="Aberkane O" first="Ouafaa" last="Aberkane">Ouafaa Aberkane</name><affiliation><nlm:affiliation>Department of Direction de la recherche clinique et de l'innovation, Strasbourg University Hospital, Strasbourg, France.</nlm:affiliation></affiliation></author><author><name sortKey="Vazel, Marion" sort="Vazel, Marion" uniqKey="Vazel M" first="Marion" last="Vazel">Marion Vazel</name><affiliation><nlm:affiliation>Department of Direction de la recherche clinique et de l'innovation, Strasbourg University Hospital, Strasbourg, France.</nlm:affiliation></affiliation></author><author><name sortKey="Back, Christelle" sort="Back, Christelle" uniqKey="Back C" first="Christelle" last="Back">Christelle Back</name><affiliation><nlm:affiliation>Department of Direction de la recherche clinique et de l'innovation, Strasbourg University Hospital, Strasbourg, France.</nlm:affiliation></affiliation></author><author><name sortKey="Candon, Sophie" sort="Candon, Sophie" uniqKey="Candon S" first="Sophie" last="Candon">Sophie Candon</name><affiliation><nlm:affiliation>Department of Immunology, Hôpital Necker, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Chatenoud, Lucienne" sort="Chatenoud, Lucienne" uniqKey="Chatenoud L" first="Lucienne" last="Chatenoud">Lucienne Chatenoud</name><affiliation><nlm:affiliation>Department of Immunology, Hôpital Necker, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Perrodeau, Elodie" sort="Perrodeau, Elodie" uniqKey="Perrodeau E" first="Elodie" last="Perrodeau">Elodie Perrodeau</name><affiliation><nlm:affiliation>Department of Epidemiology and Biostatistics, Hotel Dieu, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Sibilia, Jean" sort="Sibilia, Jean" uniqKey="Sibilia J" first="Jean" last="Sibilia">Jean Sibilia</name><affiliation><nlm:affiliation>Department of Rheumatology, National Reference Center for Systemic Autoimmune Diseases, Strasbourg University Hospital, Université de Strasbourg, Strasbourg, France.</nlm:affiliation></affiliation></author><author><name sortKey="Ravaud, Philippe" sort="Ravaud, Philippe" uniqKey="Ravaud P" first="Philippe" last="Ravaud">Philippe Ravaud</name><affiliation><nlm:affiliation>Department of Epidemiology and Biostatistics, Hotel Dieu, Paris, France.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27654603</idno><idno type="pmid">27654603</idno><idno type="doi">10.1001/jama.2016.13512</idno><idno type="wicri:Area/PubMed/Corpus">000013</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Non-TNF-Targeted Biologic vs a Second Anti-TNF Drug to Treat Rheumatoid Arthritis in Patients With Insufficient Response to a First Anti-TNF Drug: A Randomized Clinical Trial.</title><author><name sortKey="Gottenberg, Jacques Eric" sort="Gottenberg, Jacques Eric" uniqKey="Gottenberg J" first="Jacques-Eric" last="Gottenberg">Jacques-Eric Gottenberg</name><affiliation><nlm:affiliation>Department of Rheumatology, National Reference Center for Systemic Autoimmune Diseases, Strasbourg University Hospital, Université de Strasbourg, Strasbourg, France.</nlm:affiliation></affiliation></author><author><name sortKey="Brocq, Olivier" sort="Brocq, Olivier" uniqKey="Brocq O" first="Olivier" last="Brocq">Olivier Brocq</name><affiliation><nlm:affiliation>Department of Rheumatology, Centre Hospitalier Princesse Grâce, Monaco.</nlm:affiliation></affiliation></author><author><name sortKey="Perdriger, Aleth" sort="Perdriger, Aleth" uniqKey="Perdriger A" first="Aleth" last="Perdriger">Aleth Perdriger</name><affiliation><nlm:affiliation>Department of Rheumatology, Rennes University Hospital, Rennes, France.</nlm:affiliation></affiliation></author><author><name sortKey="Lassoued, Slim" sort="Lassoued, Slim" uniqKey="Lassoued S" first="Slim" last="Lassoued">Slim Lassoued</name><affiliation><nlm:affiliation>Department of Rheumatology, Centre Hospitalier de Cahors, Cahors, France.</nlm:affiliation></affiliation></author><author><name sortKey="Berthelot, Jean Marie" sort="Berthelot, Jean Marie" uniqKey="Berthelot J" first="Jean-Marie" last="Berthelot">Jean-Marie Berthelot</name><affiliation><nlm:affiliation>Department of Rheumatology, Nantes University Hospital, Nantes, France.</nlm:affiliation></affiliation></author><author><name sortKey="Wendling, Daniel" sort="Wendling, Daniel" uniqKey="Wendling D" first="Daniel" last="Wendling">Daniel Wendling</name><affiliation><nlm:affiliation>Department of Rheumatology, Besançon University Hospital, Besançon, France.</nlm:affiliation></affiliation></author><author><name sortKey="Euller Ziegler, Liana" sort="Euller Ziegler, Liana" uniqKey="Euller Ziegler L" first="Liana" last="Euller-Ziegler">Liana Euller-Ziegler</name><affiliation><nlm:affiliation>Department of Rheumatology, Nice University Hospital, Nice, France.</nlm:affiliation></affiliation></author><author><name sortKey="Soubrier, Martin" sort="Soubrier, Martin" uniqKey="Soubrier M" first="Martin" last="Soubrier">Martin Soubrier</name><affiliation><nlm:affiliation>Department of Rheumatology, Clermont-Ferrand University Hospital, Clermont-Ferrand, France.</nlm:affiliation></affiliation></author><author><name sortKey="Richez, Christophe" sort="Richez, Christophe" uniqKey="Richez C" first="Christophe" last="Richez">Christophe Richez</name><affiliation><nlm:affiliation>Department of Rheumatology, Bordeaux University Hospital, Bordeaux, France.</nlm:affiliation></affiliation></author><author><name sortKey="Fautrel, Bruno" sort="Fautrel, Bruno" uniqKey="Fautrel B" first="Bruno" last="Fautrel">Bruno Fautrel</name><affiliation><nlm:affiliation>Department of Rheumatology, Hôpital La Pitié Salpétrière, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Constantin, Arnaud L" sort="Constantin, Arnaud L" uniqKey="Constantin A" first="Arnaud L" last="Constantin">Arnaud L. Constantin</name><affiliation><nlm:affiliation>Department of Rheumatology, Toulouse University Hospital, Toulouse, France.</nlm:affiliation></affiliation></author><author><name sortKey="Mariette, Xavier" sort="Mariette, Xavier" uniqKey="Mariette X" first="Xavier" last="Mariette">Xavier Mariette</name><affiliation><nlm:affiliation>Department of Rheumatology, Hôpital Kremlin Bicêtre, Kremlin Bicêtre, France.</nlm:affiliation></affiliation></author><author><name sortKey="Morel, Jacques" sort="Morel, Jacques" uniqKey="Morel J" first="Jacques" last="Morel">Jacques Morel</name><affiliation><nlm:affiliation>Department of Rheumatology, Montpellier University Hospital, Montpellier, France.</nlm:affiliation></affiliation></author><author><name sortKey="Gilson, Melanie" sort="Gilson, Melanie" uniqKey="Gilson M" first="Melanie" last="Gilson">Melanie Gilson</name><affiliation><nlm:affiliation>Department of Rheumatology, Grenoble University Hospital, Grenoble, France.</nlm:affiliation></affiliation></author><author><name sortKey="Cormier, Gregoire" sort="Cormier, Gregoire" uniqKey="Cormier G" first="Gregoire" last="Cormier">Gregoire Cormier</name><affiliation><nlm:affiliation>Department of Rheumatology, Centre Hospitalier de La Roche Sur Yon, La Roche Sur Yon, France.</nlm:affiliation></affiliation></author><author><name sortKey="Salmon, Jean Hugues" sort="Salmon, Jean Hugues" uniqKey="Salmon J" first="Jean Hugues" last="Salmon">Jean Hugues Salmon</name><affiliation><nlm:affiliation>Department of Rheumatology, Reims University Hospital, Reims, France.</nlm:affiliation></affiliation></author><author><name sortKey="Rist, Stephanie" sort="Rist, Stephanie" uniqKey="Rist S" first="Stephanie" last="Rist">Stephanie Rist</name><affiliation><nlm:affiliation>Department of Rheumatology, Centre Hospitalier d'Orléans, Orléans, France.</nlm:affiliation></affiliation></author><author><name sortKey="Liote, Frederic" sort="Liote, Frederic" uniqKey="Liote F" first="Frederic" last="Lioté">Frederic Lioté</name><affiliation><nlm:affiliation>Department of Rheumatology, Hôpital Lariboisière, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Marotte, Hubert" sort="Marotte, Hubert" uniqKey="Marotte H" first="Hubert" last="Marotte">Hubert Marotte</name><affiliation><nlm:affiliation>Department of Rheumatology, Saint-Etienne University Hospital, Saint-Etienne, France.</nlm:affiliation></affiliation></author><author><name sortKey="Bonnet, Christine" sort="Bonnet, Christine" uniqKey="Bonnet C" first="Christine" last="Bonnet">Christine Bonnet</name><affiliation><nlm:affiliation>Department of Rheumatology, Limoges University Hospital, Limoges, France.</nlm:affiliation></affiliation></author><author><name sortKey="Marcelli, Christian" sort="Marcelli, Christian" uniqKey="Marcelli C" first="Christian" last="Marcelli">Christian Marcelli</name><affiliation><nlm:affiliation>Department of Rheumatology, Caen University Hospital, Caen France.</nlm:affiliation></affiliation></author><author><name sortKey="Sellam, Jeremie" sort="Sellam, Jeremie" uniqKey="Sellam J" first="Jeremie" last="Sellam">Jeremie Sellam</name><affiliation><nlm:affiliation>Department of Rheumatology, Hôpital Saint-Antoine, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Meyer, Olivier" sort="Meyer, Olivier" uniqKey="Meyer O" first="Olivier" last="Meyer">Olivier Meyer</name><affiliation><nlm:affiliation>Department of Rheumatology, Hôpital Bichat, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Solau Gervais, Elisabeth" sort="Solau Gervais, Elisabeth" uniqKey="Solau Gervais E" first="Elisabeth" last="Solau-Gervais">Elisabeth Solau-Gervais</name><affiliation><nlm:affiliation>Department of Rheumatology, Poitiers University Hospital, Poitiers, France.</nlm:affiliation></affiliation></author><author><name sortKey="Guis, Sandrine" sort="Guis, Sandrine" uniqKey="Guis S" first="Sandrine" last="Guis">Sandrine Guis</name><affiliation><nlm:affiliation>Department of Rheumatology, Marseille University Hospital, Marseille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Ziza, Jean Marc" sort="Ziza, Jean Marc" uniqKey="Ziza J" first="Jean-Marc" last="Ziza">Jean-Marc Ziza</name><affiliation><nlm:affiliation>Department of Rheumatology, Hôpital La Croix Saint Simon, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Zarnitsky, Charles" sort="Zarnitsky, Charles" uniqKey="Zarnitsky C" first="Charles" last="Zarnitsky">Charles Zarnitsky</name><affiliation><nlm:affiliation>Department of Rheumatology, Centre Hospitalier du Havre, Le Havre, France.</nlm:affiliation></affiliation></author><author><name sortKey="Chary Valckenaere, Isabelle" sort="Chary Valckenaere, Isabelle" uniqKey="Chary Valckenaere I" first="Isabelle" last="Chary-Valckenaere">Isabelle Chary-Valckenaere</name><affiliation><nlm:affiliation>Department of Rheumatology, Nancy University Hospital, Nancy, France.</nlm:affiliation></affiliation></author><author><name sortKey="Vittecoq, Olivier" sort="Vittecoq, Olivier" uniqKey="Vittecoq O" first="Olivier" last="Vittecoq">Olivier Vittecoq</name><affiliation><nlm:affiliation>Department of Rheumatology, Rouen University Hospital, Rouen, France.</nlm:affiliation></affiliation></author><author><name sortKey="Saraux, Alain" sort="Saraux, Alain" uniqKey="Saraux A" first="Alain" last="Saraux">Alain Saraux</name><affiliation><nlm:affiliation>Department of Rheumatology, Brest University Hospital, Brest, France.</nlm:affiliation></affiliation></author><author><name sortKey="Pers, Yves Marie" sort="Pers, Yves Marie" uniqKey="Pers Y" first="Yves-Marie" last="Pers">Yves-Marie Pers</name><affiliation><nlm:affiliation>Department of Rheumatology, Montpellier University Hospital, Montpellier, France.</nlm:affiliation></affiliation></author><author><name sortKey="Gayraud, Martine" sort="Gayraud, Martine" uniqKey="Gayraud M" first="Martine" last="Gayraud">Martine Gayraud</name><affiliation><nlm:affiliation>Department of Internal Medicine, Institut Montsouris, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Bolla, Gilles" sort="Bolla, Gilles" uniqKey="Bolla G" first="Gilles" last="Bolla">Gilles Bolla</name><affiliation><nlm:affiliation>Department of Rheumatology, Centre Hospitalier de Cannes, Cannes, France.</nlm:affiliation></affiliation></author><author><name sortKey="Claudepierre, Pascal" sort="Claudepierre, Pascal" uniqKey="Claudepierre P" first="Pascal" last="Claudepierre">Pascal Claudepierre</name><affiliation><nlm:affiliation>Department of Rheumatology, Hôpital Mondor, Créteil, France.</nlm:affiliation></affiliation></author><author><name sortKey="Ardizzone, Marc" sort="Ardizzone, Marc" uniqKey="Ardizzone M" first="Marc" last="Ardizzone">Marc Ardizzone</name><affiliation><nlm:affiliation>Department of Rheumatology, Centre Hospitalier de Mulhouse, Mulhouse, France.</nlm:affiliation></affiliation></author><author><name sortKey="Dernis, Emmanuelle" sort="Dernis, Emmanuelle" uniqKey="Dernis E" first="Emmanuelle" last="Dernis">Emmanuelle Dernis</name><affiliation><nlm:affiliation>Department of Rheumatology, Centre Hospitalier du Mans, Le Mans, France.</nlm:affiliation></affiliation></author><author><name sortKey="Breban, Maxime A" sort="Breban, Maxime A" uniqKey="Breban M" first="Maxime A" last="Breban">Maxime A. Breban</name><affiliation><nlm:affiliation>Department of Rheumatology, Hôpital Ambroise Paré, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Fain, Olivier" sort="Fain, Olivier" uniqKey="Fain O" first="Olivier" last="Fain">Olivier Fain</name><affiliation><nlm:affiliation>Department of Internal Medicine, Hôpital Saint-Antoine, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Balblanc, Jean Charles" sort="Balblanc, Jean Charles" uniqKey="Balblanc J" first="Jean-Charles" last="Balblanc">Jean-Charles Balblanc</name><affiliation><nlm:affiliation>Department of Rheumatology, Centre Hospitalier de Belfort, Belfort, France.</nlm:affiliation></affiliation></author><author><name sortKey="Aberkane, Ouafaa" sort="Aberkane, Ouafaa" uniqKey="Aberkane O" first="Ouafaa" last="Aberkane">Ouafaa Aberkane</name><affiliation><nlm:affiliation>Department of Direction de la recherche clinique et de l'innovation, Strasbourg University Hospital, Strasbourg, France.</nlm:affiliation></affiliation></author><author><name sortKey="Vazel, Marion" sort="Vazel, Marion" uniqKey="Vazel M" first="Marion" last="Vazel">Marion Vazel</name><affiliation><nlm:affiliation>Department of Direction de la recherche clinique et de l'innovation, Strasbourg University Hospital, Strasbourg, France.</nlm:affiliation></affiliation></author><author><name sortKey="Back, Christelle" sort="Back, Christelle" uniqKey="Back C" first="Christelle" last="Back">Christelle Back</name><affiliation><nlm:affiliation>Department of Direction de la recherche clinique et de l'innovation, Strasbourg University Hospital, Strasbourg, France.</nlm:affiliation></affiliation></author><author><name sortKey="Candon, Sophie" sort="Candon, Sophie" uniqKey="Candon S" first="Sophie" last="Candon">Sophie Candon</name><affiliation><nlm:affiliation>Department of Immunology, Hôpital Necker, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Chatenoud, Lucienne" sort="Chatenoud, Lucienne" uniqKey="Chatenoud L" first="Lucienne" last="Chatenoud">Lucienne Chatenoud</name><affiliation><nlm:affiliation>Department of Immunology, Hôpital Necker, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Perrodeau, Elodie" sort="Perrodeau, Elodie" uniqKey="Perrodeau E" first="Elodie" last="Perrodeau">Elodie Perrodeau</name><affiliation><nlm:affiliation>Department of Epidemiology and Biostatistics, Hotel Dieu, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Sibilia, Jean" sort="Sibilia, Jean" uniqKey="Sibilia J" first="Jean" last="Sibilia">Jean Sibilia</name><affiliation><nlm:affiliation>Department of Rheumatology, National Reference Center for Systemic Autoimmune Diseases, Strasbourg University Hospital, Université de Strasbourg, Strasbourg, France.</nlm:affiliation></affiliation></author><author><name sortKey="Ravaud, Philippe" sort="Ravaud, Philippe" uniqKey="Ravaud P" first="Philippe" last="Ravaud">Philippe Ravaud</name><affiliation><nlm:affiliation>Department of Epidemiology and Biostatistics, Hotel Dieu, Paris, France.</nlm:affiliation></affiliation></author></analytic><series><title level="j">JAMA</title><idno type="eISSN">1538-3598</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">One-third of patients with rheumatoid arthritis show inadequate response to tumor necrosis factor α (TNF-α) inhibitors; little guidance on choosing the next treatment exists.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">27654603</PMID><DateCreated><Year>2016</Year><Month>9</Month><Day>22</Day></DateCreated><DateRevised><Year>2016</Year><Month>10</Month><Day>17</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1538-3598</ISSN><JournalIssue CitedMedium="Internet"><Volume>316</Volume><Issue>11</Issue><PubDate><Year>2016</Year><Month>Sep</Month><Day>20</Day></PubDate></JournalIssue><Title>JAMA</Title><ISOAbbreviation>JAMA</ISOAbbreviation></Journal><ArticleTitle>Non-TNF-Targeted Biologic vs a Second Anti-TNF Drug to Treat Rheumatoid Arthritis in Patients With Insufficient Response to a First Anti-TNF Drug: A Randomized Clinical Trial.</ArticleTitle><Pagination><MedlinePgn>1172-1180</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1001/jama.2016.13512</ELocationID><Abstract><AbstractText Label="Importance" NlmCategory="UNASSIGNED">One-third of patients with rheumatoid arthritis show inadequate response to tumor necrosis factor α (TNF-α) inhibitors; little guidance on choosing the next treatment exists.</AbstractText><AbstractText Label="Objective" NlmCategory="UNASSIGNED">To compare the efficacy of a non-TNF-targeted biologic (non-TNF) vs a second anti-TNF drug for patients with insufficient response to a TNF inhibitor.</AbstractText><AbstractText Label="Design, Setting, and Participants" NlmCategory="UNASSIGNED">A total of 300 patients (conducted between 2009-2012) with rheumatoid arthritis, with persistent disease activity (disease activity score in 28 joints-erythrocyte sedimentation rate [DAS28-ESR] ≥ 3.2 [range, 0-9.3]) and an insufficient response to anti-TNF therapy were included in a 52-week multicenter, pragmatic, open-label randomized clinical trial. The final follow-up date was in August 2013.</AbstractText><AbstractText Label="Interventions" NlmCategory="UNASSIGNED">Patients were randomly assigned (1:1) to receive a non-TNF-targeted biologic agent or an anti-TNF that differed from their previous treatment. The choice of the biologic prescribed within each randomized group was left to the treating clinician.</AbstractText><AbstractText Label="Main Outcomes and Measures" NlmCategory="UNASSIGNED">The primary outcome was the proportion of patients with good or moderate response according to the European League Against Rheumatism (EULAR) scale at week 24. Secondary outcomes included the EULAR response at weeks 12 and 52; at weeks 12, 24, and 52; DAS28ESR, low disease activity (DAS28 ≤3.2), remission (DAS28 ≤2.6); serious adverse events; and serious infections.</AbstractText><AbstractText Label="Results" NlmCategory="UNASSIGNED">Of the 300 randomized patients (243 [83.2%] women; mean [SD] age, 57.1 [12.2] years; baseline DAS28-ESR, 5.1 [1.1]), 269 (89.7%) completed the study. At week 24, 101 of 146 patients (69%) in the non-TNF group and 76 (52%) in the second anti-TNF group achieved a good or moderate EULAR response (OR, 2.06; 95% CI, 1.27-3.37; P = .004, with imputation of missing data; absolute difference, 17.2%; 95% CI, 6.2% to 28.2%). The DAS28-ESR was lower in the non-TNF group than in the second anti-TNF group (mean difference adjusted for baseline differences, -0.43; 95% CI, -0.72 to -0.14; P = .004). At weeks 24 and 52, more patients in the non-TNF group vs the second anti-TNF group showed low disease activity (45% vs 28% at week 24; OR, 2.09; 95% CI, 1.27 to 3.43; P = .004 and 41% vs 23% at week 52; OR, 2.26; 95% CI, 1.33 to 3.86; P = .003).</AbstractText><AbstractText Label="Conclusions and Relevance" NlmCategory="UNASSIGNED">Among patients with rheumatoid arthritis previously treated with anti-TNF drugs but with inadequate primary response, a non-TNF biologic agent was more effective in achieving a good or moderate disease activity response at 24 weeks than was the second anti-TNF medication.</AbstractText><AbstractText Label="Trial Registration" NlmCategory="UNASSIGNED">clinicaltrials.gov Identifier: NCT01000441.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Gottenberg</LastName><ForeName>Jacques-Eric</ForeName><Initials>JE</Initials><AffiliationInfo><Affiliation>Department of Rheumatology, National Reference Center for Systemic Autoimmune Diseases, Strasbourg University Hospital, Université de Strasbourg, Strasbourg, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brocq</LastName><ForeName>Olivier</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>Department of Rheumatology, Centre Hospitalier Princesse Grâce, Monaco.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Perdriger</LastName><ForeName>Aleth</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Rheumatology, Rennes University Hospital, Rennes, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lassoued</LastName><ForeName>Slim</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Rheumatology, Centre Hospitalier de Cahors, Cahors, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Berthelot</LastName><ForeName>Jean-Marie</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>Department of Rheumatology, Nantes University Hospital, Nantes, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wendling</LastName><ForeName>Daniel</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Rheumatology, Besançon University Hospital, Besançon, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Euller-Ziegler</LastName><ForeName>Liana</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Rheumatology, Nice University Hospital, Nice, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Soubrier</LastName><ForeName>Martin</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Rheumatology, Clermont-Ferrand University Hospital, Clermont-Ferrand, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Richez</LastName><ForeName>Christophe</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Rheumatology, Bordeaux University Hospital, Bordeaux, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fautrel</LastName><ForeName>Bruno</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of Rheumatology, Hôpital La Pitié Salpétrière, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Constantin</LastName><ForeName>Arnaud L</ForeName><Initials>AL</Initials><AffiliationInfo><Affiliation>Department of Rheumatology, Toulouse University Hospital, Toulouse, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mariette</LastName><ForeName>Xavier</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Department of Rheumatology, Hôpital Kremlin Bicêtre, Kremlin Bicêtre, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Morel</LastName><ForeName>Jacques</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Rheumatology, Montpellier University Hospital, Montpellier, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gilson</LastName><ForeName>Melanie</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Rheumatology, Grenoble University Hospital, Grenoble, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cormier</LastName><ForeName>Gregoire</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Rheumatology, Centre Hospitalier de La Roche Sur Yon, La Roche Sur Yon, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Salmon</LastName><ForeName>Jean Hugues</ForeName><Initials>JH</Initials><AffiliationInfo><Affiliation>Department of Rheumatology, Reims University Hospital, Reims, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rist</LastName><ForeName>Stephanie</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Rheumatology, Centre Hospitalier d'Orléans, Orléans, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lioté</LastName><ForeName>Frederic</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Department of Rheumatology, Hôpital Lariboisière, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Marotte</LastName><ForeName>Hubert</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Rheumatology, Saint-Etienne University Hospital, Saint-Etienne, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bonnet</LastName><ForeName>Christine</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Rheumatology, Limoges University Hospital, Limoges, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Marcelli</LastName><ForeName>Christian</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Rheumatology, Caen University Hospital, Caen France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sellam</LastName><ForeName>Jeremie</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Rheumatology, Hôpital Saint-Antoine, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Meyer</LastName><ForeName>Olivier</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>Department of Rheumatology, Hôpital Bichat, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Solau-Gervais</LastName><ForeName>Elisabeth</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Rheumatology, Poitiers University Hospital, Poitiers, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Guis</LastName><ForeName>Sandrine</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Rheumatology, Marseille University Hospital, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ziza</LastName><ForeName>Jean-Marc</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>Department of Rheumatology, Hôpital La Croix Saint Simon, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zarnitsky</LastName><ForeName>Charles</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Rheumatology, Centre Hospitalier du Havre, Le Havre, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chary-Valckenaere</LastName><ForeName>Isabelle</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Department of Rheumatology, Nancy University Hospital, Nancy, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vittecoq</LastName><ForeName>Olivier</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>Department of Rheumatology, Rouen University Hospital, Rouen, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Saraux</LastName><ForeName>Alain</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Rheumatology, Brest University Hospital, Brest, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pers</LastName><ForeName>Yves-Marie</ForeName><Initials>YM</Initials><AffiliationInfo><Affiliation>Department of Rheumatology, Montpellier University Hospital, Montpellier, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gayraud</LastName><ForeName>Martine</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, Institut Montsouris, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bolla</LastName><ForeName>Gilles</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Rheumatology, Centre Hospitalier de Cannes, Cannes, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Claudepierre</LastName><ForeName>Pascal</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Rheumatology, Hôpital Mondor, Créteil, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ardizzone</LastName><ForeName>Marc</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Rheumatology, Centre Hospitalier de Mulhouse, Mulhouse, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dernis</LastName><ForeName>Emmanuelle</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Rheumatology, Centre Hospitalier du Mans, Le Mans, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Breban</LastName><ForeName>Maxime A</ForeName><Initials>MA</Initials><AffiliationInfo><Affiliation>Department of Rheumatology, Hôpital Ambroise Paré, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fain</LastName><ForeName>Olivier</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, Hôpital Saint-Antoine, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Balblanc</LastName><ForeName>Jean-Charles</ForeName><Initials>JC</Initials><AffiliationInfo><Affiliation>Department of Rheumatology, Centre Hospitalier de Belfort, Belfort, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Aberkane</LastName><ForeName>Ouafaa</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>Department of Direction de la recherche clinique et de l'innovation, Strasbourg University Hospital, Strasbourg, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vazel</LastName><ForeName>Marion</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Direction de la recherche clinique et de l'innovation, Strasbourg University Hospital, Strasbourg, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Back</LastName><ForeName>Christelle</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Direction de la recherche clinique et de l'innovation, Strasbourg University Hospital, Strasbourg, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Candon</LastName><ForeName>Sophie</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Immunology, Hôpital Necker, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chatenoud</LastName><ForeName>Lucienne</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Immunology, Hôpital Necker, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Perrodeau</LastName><ForeName>Elodie</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Epidemiology and Biostatistics, Hotel Dieu, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sibilia</LastName><ForeName>Jean</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Rheumatology, National Reference Center for Systemic Autoimmune Diseases, Strasbourg University Hospital, Université de Strasbourg, Strasbourg, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ravaud</LastName><ForeName>Philippe</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Epidemiology and Biostatistics, Hotel Dieu, Paris, France.</Affiliation></AffiliationInfo></Author></AuthorList><Language>ENG</Language><PublicationTypeList><PublicationType UI="">JOURNAL ARTICLE</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>JAMA</MedlineTA><NlmUniqueID>7501160</NlmUniqueID><ISSNLinking>0098-7484</ISSNLinking></MedlineJournalInfo></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>9</Month><Day>23</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>9</Month><Day>23</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>9</Month><Day>23</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27654603</ArticleId><ArticleId IdType="pii">2553449</ArticleId><ArticleId IdType="doi">10.1001/jama.2016.13512</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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