Comparison of the intraocular pressure lowering effect of latanoprost and a fixed combination of timolol-pilocarpine eye drops in patients insufficiently controlled with β adrenergic antagonists
Identifieur interne : 001968 ( Main/Curation ); précédent : 001967; suivant : 001969Comparison of the intraocular pressure lowering effect of latanoprost and a fixed combination of timolol-pilocarpine eye drops in patients insufficiently controlled with β adrenergic antagonists
Auteurs : Jean-Philippe Nordmann ; Mats Söderström ; Jean-François Rouland ; François MalecazeSource :
- British Journal of Ophthalmology [ 0007-1161 ] ; 2000-02-01.
Abstract
AIMS To compare the effect on intraocular pressure (IOP) of latanoprost monotherapy and timolol-pilocarpine in patients with glaucoma or ocular hypertension with inadequately controlled IOP on topical β adrenergic antagonists. METHODS This was a multicentre, randomised, observer masked, 6 week study performed in France and Sweden. 23 centres enrolled 237 patients with glaucoma or ocular hypertension and an IOP of at least 22 mm Hg on treatment with topical β adrenergic antagonists, alone or in combination. After a 21 day run in period on timolol 0.5% twice daily, patients were randomised either to latanoprost 0.005% once daily or to a fixed combination of timolol-pilocarpine twice daily. Changes in mean diurnal IOP from the baseline to the 6 week visit were determined with an analysis of covariance. RESULTS Mean diurnal IOP was statistically significantly decreased from baseline in both groups (p<0.001). Switching to latanoprost treatment reduced mean diurnal IOP by 5.4 (SEM 0.3) mm Hg (ANCOVA −22%) and switching to timolol-pilocarpine treatment reduced mean diurnal IOP by 4.9 (0.4) mm Hg (−20%). Blurred vision, decreased visual acuity, decreased twilight vision, and headache were statistically significantly more frequent in the timolol-pilocarpine group. CONCLUSIONS Latanoprost monotherapy was at least as effective as fixed combination timolol-pilocarpine twice daily treatment in reducing mean diurnal IOP in patients not adequately controlled on topical β adrenergic antagonists. Latanoprost was better tolerated than timolol-pilocarpine regarding side effects. These results indicate that a switch to latanoprost monotherapy can be attempted before combination therapy is initiated.
Url:
- https://api.istex.fr/document/0B27EB2DD40967F4CA50B0FABCE95ECE70E9BDCC/fulltext/pdf
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1723381
DOI: 10.1136/bjo.84.2.181
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: Pour aller vers cette notice dans l'étape Curation :001196
- to stream Istex, to step Curation: Pour aller vers cette notice dans l'étape Curation :001196
- to stream Istex, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000A06
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000182
- to stream Pmc, to step Curation: Pour aller vers cette notice dans l'étape Curation :000180
- to stream Pmc, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000156
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :000009
- to stream Ncbi, to step Curation: Pour aller vers cette notice dans l'étape Curation :000009
- to stream Ncbi, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000009
- to stream Main, to step Merge: Pour aller vers cette notice dans l'étape Curation :001A15
Links to Exploration step
ISTEX:0B27EB2DD40967F4CA50B0FABCE95ECE70E9BDCCLe document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Comparison of the intraocular pressure lowering effect of latanoprost and a fixed combination of timolol-pilocarpine eye drops in patients insufficiently controlled with β adrenergic antagonists</title>
<author><name sortKey="Nordmann, Jean Philippe" sort="Nordmann, Jean Philippe" uniqKey="Nordmann J" first="Jean-Philippe" last="Nordmann">Jean-Philippe Nordmann</name>
</author>
<author><name sortKey="Soderstrom, Mats" sort="Soderstrom, Mats" uniqKey="Soderstrom M" first="Mats" last="Söderström">Mats Söderström</name>
</author>
<author><name sortKey="Rouland, Jean Francois" sort="Rouland, Jean Francois" uniqKey="Rouland J" first="Jean-François" last="Rouland">Jean-François Rouland</name>
</author>
<author><name sortKey="Malecaze, Francois" sort="Malecaze, Francois" uniqKey="Malecaze F" first="François" last="Malecaze">François Malecaze</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:0B27EB2DD40967F4CA50B0FABCE95ECE70E9BDCC</idno>
<date when="2000" year="2000">2000</date>
<idno type="doi">10.1136/bjo.84.2.181</idno>
<idno type="url">https://api.istex.fr/document/0B27EB2DD40967F4CA50B0FABCE95ECE70E9BDCC/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">001196</idno>
<idno type="wicri:Area/Istex/Curation">001196</idno>
<idno type="wicri:Area/Istex/Checkpoint">000A06</idno>
<idno type="wicri:doubleKey">0007-1161:2000:Nordmann J:comparison:of:the</idno>
<idno type="wicri:source">PMC</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1723381</idno>
<idno type="RBID">PMC:1723381</idno>
<idno type="wicri:Area/Pmc/Corpus">000182</idno>
<idno type="wicri:Area/Pmc/Curation">000180</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000156</idno>
<idno type="wicri:Area/Ncbi/Merge">000009</idno>
<idno type="wicri:Area/Ncbi/Curation">000009</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000009</idno>
<idno type="wicri:doubleKey">0007-1161:2000:Nordmann J:comparison:of:the</idno>
<idno type="wicri:Area/Main/Merge">001A15</idno>
<idno type="wicri:Area/Main/Curation">001968</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Comparison of the intraocular pressure lowering effect of latanoprost and a fixed combination of timolol-pilocarpine eye drops in patients insufficiently controlled with β adrenergic antagonists</title>
<author><name sortKey="Nordmann, Jean Philippe" sort="Nordmann, Jean Philippe" uniqKey="Nordmann J" first="Jean-Philippe" last="Nordmann">Jean-Philippe Nordmann</name>
</author>
<author><name sortKey="Soderstrom, Mats" sort="Soderstrom, Mats" uniqKey="Soderstrom M" first="Mats" last="Söderström">Mats Söderström</name>
</author>
<author><name sortKey="Rouland, Jean Francois" sort="Rouland, Jean Francois" uniqKey="Rouland J" first="Jean-François" last="Rouland">Jean-François Rouland</name>
</author>
<author><name sortKey="Malecaze, Francois" sort="Malecaze, Francois" uniqKey="Malecaze F" first="François" last="Malecaze">François Malecaze</name>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">British Journal of Ophthalmology</title>
<title level="j" type="abbrev">Br J Ophthalmol</title>
<idno type="ISSN">0007-1161</idno>
<idno type="eISSN">1468-2079</idno>
<imprint><publisher>BMJ Publishing Group Ltd.</publisher>
<pubPlace>BMA House, Tavistock Square, London, WC1H 9JR</pubPlace>
<date type="published" when="2000-02-01">2000-02-01</date>
<biblScope unit="volume">84</biblScope>
<biblScope unit="issue">2</biblScope>
<biblScope unit="page" from="181">181</biblScope>
</imprint>
<idno type="ISSN">0007-1161</idno>
</series>
<idno type="istex">0B27EB2DD40967F4CA50B0FABCE95ECE70E9BDCC</idno>
<idno type="DOI">10.1136/bjo.84.2.181</idno>
<idno type="href">bjophthalmol-84-181.pdf</idno>
<idno type="PMID">10655195</idno>
<idno type="local">bjophthalmol;84/2/181</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0007-1161</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass></textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract">AIMS To compare the effect on intraocular pressure (IOP) of latanoprost monotherapy and timolol-pilocarpine in patients with glaucoma or ocular hypertension with inadequately controlled IOP on topical β adrenergic antagonists. METHODS This was a multicentre, randomised, observer masked, 6 week study performed in France and Sweden. 23 centres enrolled 237 patients with glaucoma or ocular hypertension and an IOP of at least 22 mm Hg on treatment with topical β adrenergic antagonists, alone or in combination. After a 21 day run in period on timolol 0.5% twice daily, patients were randomised either to latanoprost 0.005% once daily or to a fixed combination of timolol-pilocarpine twice daily. Changes in mean diurnal IOP from the baseline to the 6 week visit were determined with an analysis of covariance. RESULTS Mean diurnal IOP was statistically significantly decreased from baseline in both groups (p<0.001). Switching to latanoprost treatment reduced mean diurnal IOP by 5.4 (SEM 0.3) mm Hg (ANCOVA −22%) and switching to timolol-pilocarpine treatment reduced mean diurnal IOP by 4.9 (0.4) mm Hg (−20%). Blurred vision, decreased visual acuity, decreased twilight vision, and headache were statistically significantly more frequent in the timolol-pilocarpine group. CONCLUSIONS Latanoprost monotherapy was at least as effective as fixed combination timolol-pilocarpine twice daily treatment in reducing mean diurnal IOP in patients not adequately controlled on topical β adrenergic antagonists. Latanoprost was better tolerated than timolol-pilocarpine regarding side effects. These results indicate that a switch to latanoprost monotherapy can be attempted before combination therapy is initiated.</div>
</front>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/France/explor/LeHavreV1/Data/Main/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001968 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Curation/biblio.hfd -nk 001968 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/France |area= LeHavreV1 |flux= Main |étape= Curation |type= RBID |clé= ISTEX:0B27EB2DD40967F4CA50B0FABCE95ECE70E9BDCC |texte= Comparison of the intraocular pressure lowering effect of latanoprost and a fixed combination of timolol-pilocarpine eye drops in patients insufficiently controlled with β adrenergic antagonists }}
This area was generated with Dilib version V0.6.25. |