Comparison of the intraocular pressure lowering effect of latanoprost and a fixed combination of timolol-pilocarpine eye drops in patients insufficiently controlled with β adrenergic antagonists
Identifieur interne : 000009 ( Ncbi/Curation ); précédent : 000008; suivant : 000010Comparison of the intraocular pressure lowering effect of latanoprost and a fixed combination of timolol-pilocarpine eye drops in patients insufficiently controlled with β adrenergic antagonists
Auteurs : J. Nordmann ; M. Soderstrom ; J. Rouland ; F. Malecaze ; F. The ; S. TheSource :
- The British Journal of Ophthalmology [ 0007-1161 ] ; 2000.
Abstract
Url:
DOI: 10.1136/bjo.84.2.181
PubMed: 10655195
PubMed Central: 1723381
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Comparison of the intraocular pressure lowering effect of latanoprost and a fixed combination of timolol-pilocarpine eye drops in patients insufficiently controlled with β adrenergic antagonists</title><author><name sortKey="Nordmann, J" sort="Nordmann, J" uniqKey="Nordmann J" first="J." last="Nordmann">J. Nordmann</name></author><author><name sortKey="Soderstrom, M" sort="Soderstrom, M" uniqKey="Soderstrom M" first="M." last="Soderstrom">M. Soderstrom</name></author><author><name sortKey="Rouland, J" sort="Rouland, J" uniqKey="Rouland J" first="J." last="Rouland">J. Rouland</name></author><author><name sortKey="Malecaze, F" sort="Malecaze, F" uniqKey="Malecaze F" first="F." last="Malecaze">F. Malecaze</name></author><author><name sortKey="The, F" sort="The, F" uniqKey="The F" first="F" last="The">F. The</name></author><author><name sortKey="The, S" sort="The, S" uniqKey="The S" first="S" last="The">S. The</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">10655195</idno><idno type="pmc">1723381</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1723381</idno><idno type="RBID">PMC:1723381</idno><idno type="doi">10.1136/bjo.84.2.181</idno><date when="2000">2000</date><idno type="wicri:Area/Pmc/Corpus">000182</idno><idno type="wicri:Area/Pmc/Curation">000180</idno><idno type="wicri:Area/Pmc/Checkpoint">000156</idno><idno type="wicri:Area/Ncbi/Merge">000009</idno><idno type="wicri:Area/Ncbi/Curation">000009</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Comparison of the intraocular pressure lowering effect of latanoprost and a fixed combination of timolol-pilocarpine eye drops in patients insufficiently controlled with β adrenergic antagonists</title><author><name sortKey="Nordmann, J" sort="Nordmann, J" uniqKey="Nordmann J" first="J." last="Nordmann">J. Nordmann</name></author><author><name sortKey="Soderstrom, M" sort="Soderstrom, M" uniqKey="Soderstrom M" first="M." last="Soderstrom">M. Soderstrom</name></author><author><name sortKey="Rouland, J" sort="Rouland, J" uniqKey="Rouland J" first="J." last="Rouland">J. Rouland</name></author><author><name sortKey="Malecaze, F" sort="Malecaze, F" uniqKey="Malecaze F" first="F." last="Malecaze">F. Malecaze</name></author><author><name sortKey="The, F" sort="The, F" uniqKey="The F" first="F" last="The">F. The</name></author><author><name sortKey="The, S" sort="The, S" uniqKey="The S" first="S" last="The">S. The</name></author></analytic><series><title level="j">The British Journal of Ophthalmology</title><idno type="ISSN">0007-1161</idno><idno type="eISSN">1468-2079</idno><imprint><date when="2000">2000</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><italic>AIMS</italic>—To compare the effect on intraocular pressure (IOP) of latanoprost monotherapy and timolol-pilocarpine in patients with glaucoma or ocular hypertension with inadequately controlled IOP on topical β adrenergic antagonists.
<italic>METHODS</italic>—This was a multicentre, randomised, observer masked, 6 week study performed in France and Sweden. 23 centres enrolled 237<sup> </sup>patients with glaucoma or ocular hypertension and an IOP of at least 22 mm Hg on treatment with topical β adrenergic antagonists, alone or in combination. After a 21 day run in period on timolol 0.5% twice daily, patients were randomised either to latanoprost 0.005% once daily or to a fixed combination of timolol-pilocarpine twice daily. Changes in mean diurnal IOP from the baseline to the 6 week visit were determined with an analysis of covariance.
<italic>RESULTS</italic>—Mean diurnal IOP was statistically significantly decreased from baseline in both groups (p<0.001). Switching to latanoprost treatment reduced mean diurnal IOP by 5.4 (SEM 0.3) mm Hg (ANCOVA −22%) and switching to timolol-pilocarpine treatment reduced mean diurnal IOP by 4.9 (0.4) mm Hg (−20%). Blurred vision, decreased visual acuity, decreased twilight vision, and headache were statistically significantly more frequent in the timolol-pilocarpine group.
<italic>CONCLUSIONS</italic>—Latanoprost monotherapy was at least as effective as fixed combination timolol-pilocarpine twice daily treatment in reducing mean diurnal IOP in patients not adequately controlled on topical β adrenergic antagonists. Latanoprost was better tolerated than timolol-pilocarpine regarding side effects. These results indicate that a switch to latanoprost monotherapy can be attempted before combination therapy is initiated.
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