Heart failure care in low- and middle-income countries: a systematic review and meta-analysis.
Identifieur interne : 003566 ( PubMed/Corpus ); précédent : 003565; suivant : 003567Heart failure care in low- and middle-income countries: a systematic review and meta-analysis.
Auteurs : Thomas Callender ; Mark Woodward ; Gregory Roth ; Farshad Farzadfar ; Jean-Christophe Lemarie ; Stéphanie Gicquel ; John Atherton ; Shadi Rahimzadeh ; Mehdi Ghaziani ; Maaz Shaikh ; Derrick Bennett ; Anushka Patel ; Carolyn S P. Lam ; Karen Sliwa ; Antonio Barretto ; Bambang Budi Siswanto ; Alejandro Diaz ; Daniel Herpin ; Henry Krum ; Thomas Eliasz ; Anna Forbes ; Alastair Kiszely ; Rajit Khosla ; Tatjana Petrinic ; Devarsetty Praveen ; Roohi Shrivastava ; Du Xin ; Stephen Macmahon ; John Mcmurray ; Kazem RahimiSource :
- PLoS medicine [ 1549-1676 ] ; 2014.
English descriptors
- KwdEn :
- MESH :
- diagnosis : Heart Failure.
- economics : Heart Failure.
- etiology : Heart Failure.
- therapy : Heart Failure.
- Developing Countries, Humans.
Abstract
Heart failure places a significant burden on patients and health systems in high-income countries. However, information about its burden in low- and middle-income countries (LMICs) is scant. We thus set out to review both published and unpublished information on the presentation, causes, management, and outcomes of heart failure in LMICs.
DOI: 10.1371/journal.pmed.1001699
PubMed: 25117081
Links to Exploration step
pubmed:25117081Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Heart failure care in low- and middle-income countries: a systematic review and meta-analysis.</title><author><name sortKey="Callender, Thomas" sort="Callender, Thomas" uniqKey="Callender T" first="Thomas" last="Callender">Thomas Callender</name><affiliation><nlm:affiliation>The George Institute for Global Health, University of Oxford, Oxford, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Woodward, Mark" sort="Woodward, Mark" uniqKey="Woodward M" first="Mark" last="Woodward">Mark Woodward</name><affiliation><nlm:affiliation>The George Institute for Global Health, University of Oxford, Oxford, United Kingdom; The George Institute for Global Health, University of Sydney, Sydney, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Roth, Gregory" sort="Roth, Gregory" uniqKey="Roth G" first="Gregory" last="Roth">Gregory Roth</name><affiliation><nlm:affiliation>Institute for Health Metrics and Evaluation, University of Washington, Seattle, Washington, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Farzadfar, Farshad" sort="Farzadfar, Farshad" uniqKey="Farzadfar F" first="Farshad" last="Farzadfar">Farshad Farzadfar</name><affiliation><nlm:affiliation>Non-Communicable Diseases Research Centre, Tehran University of Medical Sciences, Tehran, Iran; Endocrinology and Metabolism Research Centre, Tehran University of Medical Sciences, Tehran, Iran.</nlm:affiliation></affiliation></author><author><name sortKey="Lemarie, Jean Christophe" sort="Lemarie, Jean Christophe" uniqKey="Lemarie J" first="Jean-Christophe" last="Lemarie">Jean-Christophe Lemarie</name><affiliation><nlm:affiliation>Effi-Stat, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Gicquel, Stephanie" sort="Gicquel, Stephanie" uniqKey="Gicquel S" first="Stéphanie" last="Gicquel">Stéphanie Gicquel</name><affiliation><nlm:affiliation>Effi-Stat, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Atherton, John" sort="Atherton, John" uniqKey="Atherton J" first="John" last="Atherton">John Atherton</name><affiliation><nlm:affiliation>Department of Cardiology, Royal Brisbane and Women's Children Hospital and University of Queensland School of Medicine, Brisbane, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Rahimzadeh, Shadi" sort="Rahimzadeh, Shadi" uniqKey="Rahimzadeh S" first="Shadi" last="Rahimzadeh">Shadi Rahimzadeh</name><affiliation><nlm:affiliation>Non-Communicable Diseases Research Centre, Tehran University of Medical Sciences, Tehran, Iran; Department of Epidemiology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.</nlm:affiliation></affiliation></author><author><name sortKey="Ghaziani, Mehdi" sort="Ghaziani, Mehdi" uniqKey="Ghaziani M" first="Mehdi" last="Ghaziani">Mehdi Ghaziani</name><affiliation><nlm:affiliation>Non-Communicable Diseases Research Centre, Tehran University of Medical Sciences, Tehran, Iran; Endocrinology and Metabolism Research Centre, Tehran University of Medical Sciences, Tehran, Iran.</nlm:affiliation></affiliation></author><author><name sortKey="Shaikh, Maaz" sort="Shaikh, Maaz" uniqKey="Shaikh M" first="Maaz" last="Shaikh">Maaz Shaikh</name><affiliation><nlm:affiliation>The George Institute for Global Health, University of Oxford, Oxford, United Kingdom; The George Institute for Global Health, Hyderabad, India.</nlm:affiliation></affiliation></author><author><name sortKey="Bennett, Derrick" sort="Bennett, Derrick" uniqKey="Bennett D" first="Derrick" last="Bennett">Derrick Bennett</name><affiliation><nlm:affiliation>Clinical Trials Service Unit, University of Oxford, Oxford, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Patel, Anushka" sort="Patel, Anushka" uniqKey="Patel A" first="Anushka" last="Patel">Anushka Patel</name><affiliation><nlm:affiliation>The George Institute for Global Health, University of Sydney, Sydney, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Lam, Carolyn S P" sort="Lam, Carolyn S P" uniqKey="Lam C" first="Carolyn S P" last="Lam">Carolyn S P. Lam</name><affiliation><nlm:affiliation>National University of Singapore, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="Sliwa, Karen" sort="Sliwa, Karen" uniqKey="Sliwa K" first="Karen" last="Sliwa">Karen Sliwa</name><affiliation><nlm:affiliation>Hatter Institute for Cardiovascular Research in Africa, University of Cape Town, Cape Town, South Africa.</nlm:affiliation></affiliation></author><author><name sortKey="Barretto, Antonio" sort="Barretto, Antonio" uniqKey="Barretto A" first="Antonio" last="Barretto">Antonio Barretto</name><affiliation><nlm:affiliation>Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.</nlm:affiliation></affiliation></author><author><name sortKey="Siswanto, Bambang Budi" sort="Siswanto, Bambang Budi" uniqKey="Siswanto B" first="Bambang Budi" last="Siswanto">Bambang Budi Siswanto</name><affiliation><nlm:affiliation>National Cardiovascular Centre University Indonesia, Jakarta, Indonesia.</nlm:affiliation></affiliation></author><author><name sortKey="Diaz, Alejandro" sort="Diaz, Alejandro" uniqKey="Diaz A" first="Alejandro" last="Diaz">Alejandro Diaz</name><affiliation><nlm:affiliation>Universidad Nacional del Centro de la Provincia de Buenos Aires, Buenos Aires, Argentina.</nlm:affiliation></affiliation></author><author><name sortKey="Herpin, Daniel" sort="Herpin, Daniel" uniqKey="Herpin D" first="Daniel" last="Herpin">Daniel Herpin</name><affiliation><nlm:affiliation>Centre Hospitalier Universitaire de Poitiers, Poitiers Cedex, France.</nlm:affiliation></affiliation></author><author><name sortKey="Krum, Henry" sort="Krum, Henry" uniqKey="Krum H" first="Henry" last="Krum">Henry Krum</name><affiliation><nlm:affiliation>Centre of Cardiovascular Research & Education in Therapeutics, Monash University, Melbourne, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Eliasz, Thomas" sort="Eliasz, Thomas" uniqKey="Eliasz T" first="Thomas" last="Eliasz">Thomas Eliasz</name><affiliation><nlm:affiliation>The George Institute for Global Health, University of Oxford, Oxford, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Forbes, Anna" sort="Forbes, Anna" uniqKey="Forbes A" first="Anna" last="Forbes">Anna Forbes</name><affiliation><nlm:affiliation>The George Institute for Global Health, University of Oxford, Oxford, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Kiszely, Alastair" sort="Kiszely, Alastair" uniqKey="Kiszely A" first="Alastair" last="Kiszely">Alastair Kiszely</name><affiliation><nlm:affiliation>The George Institute for Global Health, University of Oxford, Oxford, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Khosla, Rajit" sort="Khosla, Rajit" uniqKey="Khosla R" first="Rajit" last="Khosla">Rajit Khosla</name><affiliation><nlm:affiliation>The George Institute for Global Health, University of Oxford, Oxford, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Petrinic, Tatjana" sort="Petrinic, Tatjana" uniqKey="Petrinic T" first="Tatjana" last="Petrinic">Tatjana Petrinic</name><affiliation><nlm:affiliation>Bodleian Healthcare Libraries, University of Oxford, Oxford, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Praveen, Devarsetty" sort="Praveen, Devarsetty" uniqKey="Praveen D" first="Devarsetty" last="Praveen">Devarsetty Praveen</name><affiliation><nlm:affiliation>The George Institute for Global Health, University of Sydney, Sydney, Australia; The George Institute for Global Health, Hyderabad, India.</nlm:affiliation></affiliation></author><author><name sortKey="Shrivastava, Roohi" sort="Shrivastava, Roohi" uniqKey="Shrivastava R" first="Roohi" last="Shrivastava">Roohi Shrivastava</name><affiliation><nlm:affiliation>The George Institute for Global Health, University of Oxford, Oxford, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Xin, Du" sort="Xin, Du" uniqKey="Xin D" first="Du" last="Xin">Du Xin</name><affiliation><nlm:affiliation>The George Institute for Global Health, Peking University, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Macmahon, Stephen" sort="Macmahon, Stephen" uniqKey="Macmahon S" first="Stephen" last="Macmahon">Stephen Macmahon</name><affiliation><nlm:affiliation>The George Institute for Global Health, University of Oxford, Oxford, United Kingdom; The George Institute for Global Health, University of Sydney, Sydney, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Mcmurray, John" sort="Mcmurray, John" uniqKey="Mcmurray J" first="John" last="Mcmurray">John Mcmurray</name><affiliation><nlm:affiliation>University of Glasgow, Glasgow, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Rahimi, Kazem" sort="Rahimi, Kazem" uniqKey="Rahimi K" first="Kazem" last="Rahimi">Kazem Rahimi</name><affiliation><nlm:affiliation>The George Institute for Global Health, University of Oxford, Oxford, United Kingdom.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:25117081</idno><idno type="pmid">25117081</idno><idno type="doi">10.1371/journal.pmed.1001699</idno><idno type="wicri:Area/PubMed/Corpus">003566</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003566</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Heart failure care in low- and middle-income countries: a systematic review and meta-analysis.</title><author><name sortKey="Callender, Thomas" sort="Callender, Thomas" uniqKey="Callender T" first="Thomas" last="Callender">Thomas Callender</name><affiliation><nlm:affiliation>The George Institute for Global Health, University of Oxford, Oxford, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Woodward, Mark" sort="Woodward, Mark" uniqKey="Woodward M" first="Mark" last="Woodward">Mark Woodward</name><affiliation><nlm:affiliation>The George Institute for Global Health, University of Oxford, Oxford, United Kingdom; The George Institute for Global Health, University of Sydney, Sydney, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Roth, Gregory" sort="Roth, Gregory" uniqKey="Roth G" first="Gregory" last="Roth">Gregory Roth</name><affiliation><nlm:affiliation>Institute for Health Metrics and Evaluation, University of Washington, Seattle, Washington, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Farzadfar, Farshad" sort="Farzadfar, Farshad" uniqKey="Farzadfar F" first="Farshad" last="Farzadfar">Farshad Farzadfar</name><affiliation><nlm:affiliation>Non-Communicable Diseases Research Centre, Tehran University of Medical Sciences, Tehran, Iran; Endocrinology and Metabolism Research Centre, Tehran University of Medical Sciences, Tehran, Iran.</nlm:affiliation></affiliation></author><author><name sortKey="Lemarie, Jean Christophe" sort="Lemarie, Jean Christophe" uniqKey="Lemarie J" first="Jean-Christophe" last="Lemarie">Jean-Christophe Lemarie</name><affiliation><nlm:affiliation>Effi-Stat, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Gicquel, Stephanie" sort="Gicquel, Stephanie" uniqKey="Gicquel S" first="Stéphanie" last="Gicquel">Stéphanie Gicquel</name><affiliation><nlm:affiliation>Effi-Stat, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Atherton, John" sort="Atherton, John" uniqKey="Atherton J" first="John" last="Atherton">John Atherton</name><affiliation><nlm:affiliation>Department of Cardiology, Royal Brisbane and Women's Children Hospital and University of Queensland School of Medicine, Brisbane, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Rahimzadeh, Shadi" sort="Rahimzadeh, Shadi" uniqKey="Rahimzadeh S" first="Shadi" last="Rahimzadeh">Shadi Rahimzadeh</name><affiliation><nlm:affiliation>Non-Communicable Diseases Research Centre, Tehran University of Medical Sciences, Tehran, Iran; Department of Epidemiology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.</nlm:affiliation></affiliation></author><author><name sortKey="Ghaziani, Mehdi" sort="Ghaziani, Mehdi" uniqKey="Ghaziani M" first="Mehdi" last="Ghaziani">Mehdi Ghaziani</name><affiliation><nlm:affiliation>Non-Communicable Diseases Research Centre, Tehran University of Medical Sciences, Tehran, Iran; Endocrinology and Metabolism Research Centre, Tehran University of Medical Sciences, Tehran, Iran.</nlm:affiliation></affiliation></author><author><name sortKey="Shaikh, Maaz" sort="Shaikh, Maaz" uniqKey="Shaikh M" first="Maaz" last="Shaikh">Maaz Shaikh</name><affiliation><nlm:affiliation>The George Institute for Global Health, University of Oxford, Oxford, United Kingdom; The George Institute for Global Health, Hyderabad, India.</nlm:affiliation></affiliation></author><author><name sortKey="Bennett, Derrick" sort="Bennett, Derrick" uniqKey="Bennett D" first="Derrick" last="Bennett">Derrick Bennett</name><affiliation><nlm:affiliation>Clinical Trials Service Unit, University of Oxford, Oxford, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Patel, Anushka" sort="Patel, Anushka" uniqKey="Patel A" first="Anushka" last="Patel">Anushka Patel</name><affiliation><nlm:affiliation>The George Institute for Global Health, University of Sydney, Sydney, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Lam, Carolyn S P" sort="Lam, Carolyn S P" uniqKey="Lam C" first="Carolyn S P" last="Lam">Carolyn S P. Lam</name><affiliation><nlm:affiliation>National University of Singapore, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="Sliwa, Karen" sort="Sliwa, Karen" uniqKey="Sliwa K" first="Karen" last="Sliwa">Karen Sliwa</name><affiliation><nlm:affiliation>Hatter Institute for Cardiovascular Research in Africa, University of Cape Town, Cape Town, South Africa.</nlm:affiliation></affiliation></author><author><name sortKey="Barretto, Antonio" sort="Barretto, Antonio" uniqKey="Barretto A" first="Antonio" last="Barretto">Antonio Barretto</name><affiliation><nlm:affiliation>Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.</nlm:affiliation></affiliation></author><author><name sortKey="Siswanto, Bambang Budi" sort="Siswanto, Bambang Budi" uniqKey="Siswanto B" first="Bambang Budi" last="Siswanto">Bambang Budi Siswanto</name><affiliation><nlm:affiliation>National Cardiovascular Centre University Indonesia, Jakarta, Indonesia.</nlm:affiliation></affiliation></author><author><name sortKey="Diaz, Alejandro" sort="Diaz, Alejandro" uniqKey="Diaz A" first="Alejandro" last="Diaz">Alejandro Diaz</name><affiliation><nlm:affiliation>Universidad Nacional del Centro de la Provincia de Buenos Aires, Buenos Aires, Argentina.</nlm:affiliation></affiliation></author><author><name sortKey="Herpin, Daniel" sort="Herpin, Daniel" uniqKey="Herpin D" first="Daniel" last="Herpin">Daniel Herpin</name><affiliation><nlm:affiliation>Centre Hospitalier Universitaire de Poitiers, Poitiers Cedex, France.</nlm:affiliation></affiliation></author><author><name sortKey="Krum, Henry" sort="Krum, Henry" uniqKey="Krum H" first="Henry" last="Krum">Henry Krum</name><affiliation><nlm:affiliation>Centre of Cardiovascular Research & Education in Therapeutics, Monash University, Melbourne, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Eliasz, Thomas" sort="Eliasz, Thomas" uniqKey="Eliasz T" first="Thomas" last="Eliasz">Thomas Eliasz</name><affiliation><nlm:affiliation>The George Institute for Global Health, University of Oxford, Oxford, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Forbes, Anna" sort="Forbes, Anna" uniqKey="Forbes A" first="Anna" last="Forbes">Anna Forbes</name><affiliation><nlm:affiliation>The George Institute for Global Health, University of Oxford, Oxford, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Kiszely, Alastair" sort="Kiszely, Alastair" uniqKey="Kiszely A" first="Alastair" last="Kiszely">Alastair Kiszely</name><affiliation><nlm:affiliation>The George Institute for Global Health, University of Oxford, Oxford, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Khosla, Rajit" sort="Khosla, Rajit" uniqKey="Khosla R" first="Rajit" last="Khosla">Rajit Khosla</name><affiliation><nlm:affiliation>The George Institute for Global Health, University of Oxford, Oxford, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Petrinic, Tatjana" sort="Petrinic, Tatjana" uniqKey="Petrinic T" first="Tatjana" last="Petrinic">Tatjana Petrinic</name><affiliation><nlm:affiliation>Bodleian Healthcare Libraries, University of Oxford, Oxford, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Praveen, Devarsetty" sort="Praveen, Devarsetty" uniqKey="Praveen D" first="Devarsetty" last="Praveen">Devarsetty Praveen</name><affiliation><nlm:affiliation>The George Institute for Global Health, University of Sydney, Sydney, Australia; The George Institute for Global Health, Hyderabad, India.</nlm:affiliation></affiliation></author><author><name sortKey="Shrivastava, Roohi" sort="Shrivastava, Roohi" uniqKey="Shrivastava R" first="Roohi" last="Shrivastava">Roohi Shrivastava</name><affiliation><nlm:affiliation>The George Institute for Global Health, University of Oxford, Oxford, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Xin, Du" sort="Xin, Du" uniqKey="Xin D" first="Du" last="Xin">Du Xin</name><affiliation><nlm:affiliation>The George Institute for Global Health, Peking University, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Macmahon, Stephen" sort="Macmahon, Stephen" uniqKey="Macmahon S" first="Stephen" last="Macmahon">Stephen Macmahon</name><affiliation><nlm:affiliation>The George Institute for Global Health, University of Oxford, Oxford, United Kingdom; The George Institute for Global Health, University of Sydney, Sydney, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Mcmurray, John" sort="Mcmurray, John" uniqKey="Mcmurray J" first="John" last="Mcmurray">John Mcmurray</name><affiliation><nlm:affiliation>University of Glasgow, Glasgow, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Rahimi, Kazem" sort="Rahimi, Kazem" uniqKey="Rahimi K" first="Kazem" last="Rahimi">Kazem Rahimi</name><affiliation><nlm:affiliation>The George Institute for Global Health, University of Oxford, Oxford, United Kingdom.</nlm:affiliation></affiliation></author></analytic><series><title level="j">PLoS medicine</title><idno type="eISSN">1549-1676</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Developing Countries</term><term>Heart Failure (diagnosis)</term><term>Heart Failure (economics)</term><term>Heart Failure (etiology)</term><term>Heart Failure (therapy)</term><term>Humans</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Heart Failure</term></keywords><keywords scheme="MESH" qualifier="economics" xml:lang="en"><term>Heart Failure</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Heart Failure</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Heart Failure</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Developing Countries</term><term>Humans</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Heart failure places a significant burden on patients and health systems in high-income countries. However, information about its burden in low- and middle-income countries (LMICs) is scant. We thus set out to review both published and unpublished information on the presentation, causes, management, and outcomes of heart failure in LMICs.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25117081</PMID><DateCreated><Year>2014</Year><Month>08</Month><Day>13</Day></DateCreated><DateCompleted><Year>2015</Year><Month>10</Month><Day>15</Day></DateCompleted><DateRevised><Year>2017</Year><Month>09</Month><Day>22</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Electronic">1549-1676</ISSN><JournalIssue CitedMedium="Internet"><Volume>11</Volume><Issue>8</Issue><PubDate><Year>2014</Year><Month>Aug</Month></PubDate></JournalIssue><Title>PLoS medicine</Title><ISOAbbreviation>PLoS Med.</ISOAbbreviation></Journal><ArticleTitle>Heart failure care in low- and middle-income countries: a systematic review and meta-analysis.</ArticleTitle><Pagination><MedlinePgn>e1001699</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1371/journal.pmed.1001699</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Heart failure places a significant burden on patients and health systems in high-income countries. However, information about its burden in low- and middle-income countries (LMICs) is scant. We thus set out to review both published and unpublished information on the presentation, causes, management, and outcomes of heart failure in LMICs.</AbstractText><AbstractText Label="METHODS AND FINDINGS" NlmCategory="RESULTS">Medline, Embase, Global Health Database, and World Health Organization regional databases were searched for studies from LMICs published between 1 January 1995 and 30 March 2014. Additional unpublished data were requested from investigators and international heart failure experts. We identified 42 studies that provided relevant information on acute hospital care (25 LMICs; 232,550 patients) and 11 studies on the management of chronic heart failure in primary care or outpatient settings (14 LMICs; 5,358 patients). The mean age of patients studied ranged from 42 y in Cameroon and Ghana to 75 y in Argentina, and mean age in studies largely correlated with the human development index of the country in which they were conducted (r = 0.71, p<0.001). Overall, ischaemic heart disease was the main reported cause of heart failure in all regions except Africa and the Americas, where hypertension was predominant. Taking both those managed acutely in hospital and those in non-acute outpatient or community settings together, 57% (95% confidence interval [CI]: 49%-64%) of patients were treated with angiotensin-converting enzyme inhibitors, 34% (95% CI: 28%-41%) with beta-blockers, and 32% (95% CI: 25%-39%) with mineralocorticoid receptor antagonists. Mean inpatient stay was 10 d, ranging from 3 d in India to 23 d in China. Acute heart failure accounted for 2.2% (range: 0.3%-7.7%) of total hospital admissions, and mean in-hospital mortality was 8% (95% CI: 6%-10%). There was substantial variation between studies (p<0.001 across all variables), and most data were from urban tertiary referral centres. Only one population-based study assessing incidence and/or prevalence of heart failure was identified.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">The presentation, underlying causes, management, and outcomes of heart failure vary substantially across LMICs. On average, the use of evidence-based medications tends to be suboptimal. Better strategies for heart failure surveillance and management in LMICs are needed. Please see later in the article for the Editors' Summary.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Callender</LastName><ForeName>Thomas</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>The George Institute for Global Health, University of Oxford, Oxford, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Woodward</LastName><ForeName>Mark</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>The George Institute for Global Health, University of Oxford, Oxford, United Kingdom; The George Institute for Global Health, University of Sydney, Sydney, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Roth</LastName><ForeName>Gregory</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Institute for Health Metrics and Evaluation, University of Washington, Seattle, Washington, United States of America.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Farzadfar</LastName><ForeName>Farshad</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Non-Communicable Diseases Research Centre, Tehran University of Medical Sciences, Tehran, Iran; Endocrinology and Metabolism Research Centre, Tehran University of Medical Sciences, Tehran, Iran.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lemarie</LastName><ForeName>Jean-Christophe</ForeName><Initials>JC</Initials><AffiliationInfo><Affiliation>Effi-Stat, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gicquel</LastName><ForeName>Stéphanie</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Effi-Stat, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Atherton</LastName><ForeName>John</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Cardiology, Royal Brisbane and Women's Children Hospital and University of Queensland School of Medicine, Brisbane, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rahimzadeh</LastName><ForeName>Shadi</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Non-Communicable Diseases Research Centre, Tehran University of Medical Sciences, Tehran, Iran; Department of Epidemiology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ghaziani</LastName><ForeName>Mehdi</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Non-Communicable Diseases Research Centre, Tehran University of Medical Sciences, Tehran, Iran; Endocrinology and Metabolism Research Centre, Tehran University of Medical Sciences, Tehran, Iran.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shaikh</LastName><ForeName>Maaz</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>The George Institute for Global Health, University of Oxford, Oxford, United Kingdom; 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Cape Town, Cape Town, South Africa.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Barretto</LastName><ForeName>Antonio</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Siswanto</LastName><ForeName>Bambang Budi</ForeName><Initials>BB</Initials><AffiliationInfo><Affiliation>National Cardiovascular Centre University Indonesia, Jakarta, Indonesia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Diaz</LastName><ForeName>Alejandro</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Universidad Nacional del Centro de la Provincia de Buenos Aires, Buenos Aires, Argentina.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Herpin</LastName><ForeName>Daniel</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Centre Hospitalier Universitaire de Poitiers, Poitiers Cedex, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Krum</LastName><ForeName>Henry</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Centre of Cardiovascular Research & Education in Therapeutics, Monash University, Melbourne, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Eliasz</LastName><ForeName>Thomas</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>The George Institute for Global Health, University of Oxford, Oxford, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Forbes</LastName><ForeName>Anna</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>The George Institute for Global Health, University of Oxford, Oxford, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kiszely</LastName><ForeName>Alastair</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>The George Institute for Global Health, University of Oxford, Oxford, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Khosla</LastName><ForeName>Rajit</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>The George Institute for Global Health, University of Oxford, Oxford, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Petrinic</LastName><ForeName>Tatjana</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Bodleian Healthcare Libraries, University of Oxford, Oxford, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Praveen</LastName><ForeName>Devarsetty</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>The George Institute for Global Health, University of Sydney, Sydney, Australia; The George Institute for Global Health, Hyderabad, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shrivastava</LastName><ForeName>Roohi</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>The George Institute for Global Health, University of Oxford, Oxford, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Xin</LastName><ForeName>Du</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>The George Institute for Global Health, Peking University, Beijing, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>MacMahon</LastName><ForeName>Stephen</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>The George Institute for Global Health, University of Oxford, Oxford, United Kingdom; The George Institute for Global Health, University of Sydney, Sydney, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>McMurray</LastName><ForeName>John</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>University of Glasgow, Glasgow, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rahimi</LastName><ForeName>Kazem</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>The George Institute for Global Health, University of Oxford, Oxford, United Kingdom.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>CDF-2013-06-012</GrantID><Agency>Department of Health</Agency><Country>United Kingdom</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D017418">Meta-Analysis</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>08</Month><Day>12</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>PLoS 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