Association between Plasma Ceramides and Phosphatidylcholines and Hippocampal Brain Volume in Late Onset Alzheimer's Disease.
Identifieur interne : 001160 ( PubMed/Checkpoint ); précédent : 001159; suivant : 001161Association between Plasma Ceramides and Phosphatidylcholines and Hippocampal Brain Volume in Late Onset Alzheimer's Disease.
Auteurs : Min Kim [Royaume-Uni] ; Alejo Nevado-Holgado [Royaume-Uni] ; Luke Whiley [Royaume-Uni] ; Stuart G. Snowden [Royaume-Uni] ; Hilkka Soininen [Finlande] ; Iwona Kloszewska [Pologne] ; Patrizia Mecocci [Italie] ; Magda Tsolaki [Grèce] ; Bruno Vellas [France] ; Madhav Thambisetty [États-Unis] ; Richard J B. Dobson [Royaume-Uni] ; John F. Powell [Royaume-Uni] ; Michelle K. Lupton [Australie] ; Andy Simmons [Royaume-Uni] ; Latha Velayudhan [Royaume-Uni] ; Simon Lovestone [Royaume-Uni] ; Petroula Proitsi [Royaume-Uni] ; Cristina Legido-Quigley [Royaume-Uni]Source :
- Journal of Alzheimer's disease : JAD [ 1875-8908 ] ; 2017.
Abstract
Lipids such as ceramides and phosphatidylcholines (PC) have been found altered in the plasma of Alzheimer's disease (AD) patients in a number of discovery studies. For this reason, the levels of 6 ceramides and 3 PCs, with different fatty acid length and saturation levels, were measured in the plasma from 412 participants (AD n = 205, Control n = 207) using mass spectrometry coupled with ultra-performance liquid chromatography. After this, associations with AD status, brain atrophy, and age-related effects were studied. In the plasma of AD participants, cross-sectional analysis revealed elevated levels of three ceramides (Cer16:0 p < 0.01, Cer18:0 p < 0.01, Cer24:1 p < 0.05). In addition, two PCs in AD plasma (PC36:5 p < 0.05, PC38:6 p < 0.05) were found to be depleted compared to the control group, with PC36:5 also associating with hippocampal atrophy (p < 0.01). Age-specific analysis further revealed that levels of Cer16:0, Cer18:0, and Cer20:0 were associated with hippocampal atrophy only in younger participants (age < 75, p < 0.05), while all 3 PCs did so in the older participants (age > 75, p < 0.05). PC36:5 was associated with AD status in the younger group (p < 0.01), while PC38:6 and 40:6 did so in the older group (p < 0.05). In this study, elevated ceramides and depleted PCs were found in the plasma from 205 AD volunteers. Our findings also suggest that dysregulation in PC and ceramide metabolism could be occurring in different stages of AD progression.
DOI: 10.3233/JAD-160645
PubMed: 27911300
Affiliations:
- Australie, Finlande, France, Grèce, Italie, Pologne, Royaume-Uni, États-Unis
- Angleterre, Grand Londres, Maryland, Midi-Pyrénées, Occitanie (région administrative), Oxfordshire
- Londres, Oxford, Toulouse
- Université d'Oxford
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Londres</region></placeName></affiliation></author><author><name sortKey="Legido Quigley, Cristina" sort="Legido Quigley, Cristina" uniqKey="Legido Quigley C" first="Cristina" last="Legido-Quigley">Cristina Legido-Quigley</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Pharmaceutical Science, King's College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Pharmaceutical Science, King's College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:27911300</idno><idno type="pmid">27911300</idno><idno type="doi">10.3233/JAD-160645</idno><idno type="wicri:Area/PubMed/Corpus">001344</idno><idno type="wicri:explorRef" 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type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Nevado Holgado, Alejo" sort="Nevado Holgado, Alejo" uniqKey="Nevado Holgado A" first="Alejo" last="Nevado-Holgado">Alejo Nevado-Holgado</name><affiliation wicri:level="4"><nlm:affiliation>Department of Psychiatry, University of Oxford, Oxford, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Psychiatry, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Whiley, Luke" sort="Whiley, Luke" uniqKey="Whiley L" first="Luke" last="Whiley">Luke Whiley</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Pharmaceutical Science, King's College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Pharmaceutical Science, King's College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Snowden, Stuart G" sort="Snowden, Stuart G" uniqKey="Snowden S" first="Stuart G" last="Snowden">Stuart G. Snowden</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Pharmaceutical Science, King's College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Pharmaceutical Science, King's College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Soininen, Hilkka" sort="Soininen, Hilkka" uniqKey="Soininen H" first="Hilkka" last="Soininen">Hilkka Soininen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Kuopio University Hospital and University of Eastern Finland, Kuopio, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Neurology, Kuopio University Hospital and University of Eastern Finland, Kuopio</wicri:regionArea><wicri:noRegion>Kuopio</wicri:noRegion></affiliation></author><author><name sortKey="Kloszewska, Iwona" sort="Kloszewska, Iwona" uniqKey="Kloszewska I" first="Iwona" last="Kloszewska">Iwona Kloszewska</name><affiliation wicri:level="1"><nlm:affiliation>Department of Old Age Psychiatry & Psychotic Disorders, Medical University of Lodz, Lodz, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Old Age Psychiatry & Psychotic Disorders, Medical University of Lodz, Lodz</wicri:regionArea><wicri:noRegion>Lodz</wicri:noRegion></affiliation></author><author><name sortKey="Mecocci, Patrizia" sort="Mecocci, Patrizia" uniqKey="Mecocci P" first="Patrizia" last="Mecocci">Patrizia Mecocci</name><affiliation wicri:level="1"><nlm:affiliation>Section of Gerontology and Geriatrics, Department of Medicine, University of Perugia, Perugia, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Section of Gerontology and Geriatrics, Department of Medicine, University of Perugia, Perugia</wicri:regionArea><wicri:noRegion>Perugia</wicri:noRegion></affiliation></author><author><name sortKey="Tsolaki, Magda" sort="Tsolaki, Magda" uniqKey="Tsolaki M" first="Magda" last="Tsolaki">Magda Tsolaki</name><affiliation wicri:level="1"><nlm:affiliation>Third Department of Neurology, Memory and Dementia Centre, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>Third Department of Neurology, Memory and Dementia Centre, Medical School, Aristotle University of Thessaloniki, Thessaloniki</wicri:regionArea><wicri:noRegion>Thessaloniki</wicri:noRegion></affiliation></author><author><name sortKey="Vellas, Bruno" sort="Vellas, Bruno" uniqKey="Vellas B" first="Bruno" last="Vellas">Bruno Vellas</name><affiliation wicri:level="3"><nlm:affiliation>Department of Internal and Geriatrics Medicine, INSERM U 1027, Gerontopole, Hôpitaux de Toulouse, Toulouse, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Internal and Geriatrics Medicine, INSERM U 1027, Gerontopole, Hôpitaux de Toulouse, Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Thambisetty, Madhav" sort="Thambisetty, Madhav" uniqKey="Thambisetty M" first="Madhav" last="Thambisetty">Madhav Thambisetty</name><affiliation wicri:level="2"><nlm:affiliation>Clinical and Translational Neuroscience Unit, Laboratory of Behavioral Neuroscience, National Institute on Aging, Baltimore, MD, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Clinical and Translational Neuroscience Unit, Laboratory of Behavioral Neuroscience, National Institute on Aging, Baltimore, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Dobson, Richard J B" sort="Dobson, Richard J B" uniqKey="Dobson R" first="Richard J B" last="Dobson">Richard J B. Dobson</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Psychiatry, Psychology & Neuroscience, King's College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Powell, John F" sort="Powell, John F" uniqKey="Powell J" first="John F" last="Powell">John F. Powell</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Psychiatry, Psychology & Neuroscience, King's College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Lupton, Michelle K" sort="Lupton, Michelle K" uniqKey="Lupton M" first="Michelle K" last="Lupton">Michelle K. Lupton</name><affiliation wicri:level="1"><nlm:affiliation>Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Qld, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Qld</wicri:regionArea><wicri:noRegion>Qld</wicri:noRegion></affiliation></author><author><name sortKey="Simmons, Andy" sort="Simmons, Andy" uniqKey="Simmons A" first="Andy" last="Simmons">Andy Simmons</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Psychiatry, Psychology & Neuroscience, King's College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Velayudhan, Latha" sort="Velayudhan, Latha" uniqKey="Velayudhan L" first="Latha" last="Velayudhan">Latha Velayudhan</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Psychiatry, Psychology & Neuroscience, King's College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Lovestone, Simon" sort="Lovestone, Simon" uniqKey="Lovestone S" first="Simon" last="Lovestone">Simon Lovestone</name><affiliation wicri:level="4"><nlm:affiliation>Department of Psychiatry, University of Oxford, Oxford, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Psychiatry, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName><orgName type="university">Université d'Oxford</orgName><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Proitsi, Petroula" sort="Proitsi, Petroula" uniqKey="Proitsi P" first="Petroula" last="Proitsi">Petroula Proitsi</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Psychiatry, Psychology & Neuroscience, King's College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Legido Quigley, Cristina" sort="Legido Quigley, Cristina" uniqKey="Legido Quigley C" first="Cristina" last="Legido-Quigley">Cristina Legido-Quigley</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Pharmaceutical Science, King's College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Pharmaceutical Science, King's College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author></analytic><series><title level="j">Journal of Alzheimer's disease : JAD</title><idno type="eISSN">1875-8908</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Lipids such as ceramides and phosphatidylcholines (PC) have been found altered in the plasma of Alzheimer's disease (AD) patients in a number of discovery studies. For this reason, the levels of 6 ceramides and 3 PCs, with different fatty acid length and saturation levels, were measured in the plasma from 412 participants (AD n = 205, Control n = 207) using mass spectrometry coupled with ultra-performance liquid chromatography. After this, associations with AD status, brain atrophy, and age-related effects were studied. In the plasma of AD participants, cross-sectional analysis revealed elevated levels of three ceramides (Cer16:0 p < 0.01, Cer18:0 p < 0.01, Cer24:1 p < 0.05). In addition, two PCs in AD plasma (PC36:5 p < 0.05, PC38:6 p < 0.05) were found to be depleted compared to the control group, with PC36:5 also associating with hippocampal atrophy (p < 0.01). Age-specific analysis further revealed that levels of Cer16:0, Cer18:0, and Cer20:0 were associated with hippocampal atrophy only in younger participants (age < 75, p < 0.05), while all 3 PCs did so in the older participants (age > 75, p < 0.05). PC36:5 was associated with AD status in the younger group (p < 0.01), while PC38:6 and 40:6 did so in the older group (p < 0.05). In this study, elevated ceramides and depleted PCs were found in the plasma from 205 AD volunteers. Our findings also suggest that dysregulation in PC and ceramide metabolism could be occurring in different stages of AD progression.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">27911300</PMID><DateCreated><Year>2016</Year><Month>12</Month><Day>02</Day></DateCreated><DateRevised><Year>2017</Year><Month>11</Month><Day>18</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1875-8908</ISSN><JournalIssue CitedMedium="Internet"><Volume>60</Volume><Issue>3</Issue><PubDate><Year>2017</Year></PubDate></JournalIssue><Title>Journal of Alzheimer's disease : JAD</Title><ISOAbbreviation>J. Alzheimers Dis.</ISOAbbreviation></Journal><ArticleTitle>Association between Plasma Ceramides and Phosphatidylcholines and Hippocampal Brain Volume in Late Onset Alzheimer's Disease.</ArticleTitle><Pagination><MedlinePgn>809-817</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.3233/JAD-160645</ELocationID><Abstract><AbstractText>Lipids such as ceramides and phosphatidylcholines (PC) have been found altered in the plasma of Alzheimer's disease (AD) patients in a number of discovery studies. For this reason, the levels of 6 ceramides and 3 PCs, with different fatty acid length and saturation levels, were measured in the plasma from 412 participants (AD n = 205, Control n = 207) using mass spectrometry coupled with ultra-performance liquid chromatography. After this, associations with AD status, brain atrophy, and age-related effects were studied. In the plasma of AD participants, cross-sectional analysis revealed elevated levels of three ceramides (Cer16:0 p < 0.01, Cer18:0 p < 0.01, Cer24:1 p < 0.05). In addition, two PCs in AD plasma (PC36:5 p < 0.05, PC38:6 p < 0.05) were found to be depleted compared to the control group, with PC36:5 also associating with hippocampal atrophy (p < 0.01). Age-specific analysis further revealed that levels of Cer16:0, Cer18:0, and Cer20:0 were associated with hippocampal atrophy only in younger participants (age < 75, p < 0.05), while all 3 PCs did so in the older participants (age > 75, p < 0.05). PC36:5 was associated with AD status in the younger group (p < 0.01), while PC38:6 and 40:6 did so in the older group (p < 0.05). In this study, elevated ceramides and depleted PCs were found in the plasma from 205 AD volunteers. Our findings also suggest that dysregulation in PC and ceramide metabolism could be occurring in different stages of AD progression.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Kim</LastName><ForeName>Min</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Institute of Pharmaceutical Science, King's College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nevado-Holgado</LastName><ForeName>Alejo</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, University of Oxford, Oxford, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Whiley</LastName><ForeName>Luke</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Institute of Pharmaceutical Science, King's College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Snowden</LastName><ForeName>Stuart G</ForeName><Initials>SG</Initials><AffiliationInfo><Affiliation>Institute of Pharmaceutical Science, King's College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Soininen</LastName><ForeName>Hilkka</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Neurology, Kuopio University Hospital and University of Eastern Finland, Kuopio, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kloszewska</LastName><ForeName>Iwona</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Department of Old Age Psychiatry & Psychotic Disorders, Medical University of Lodz, Lodz, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mecocci</LastName><ForeName>Patrizia</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Section of Gerontology and Geriatrics, Department of Medicine, University of Perugia, Perugia, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tsolaki</LastName><ForeName>Magda</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Third Department of Neurology, Memory and Dementia Centre, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vellas</LastName><ForeName>Bruno</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of Internal and Geriatrics Medicine, INSERM U 1027, Gerontopole, Hôpitaux de Toulouse, Toulouse, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Thambisetty</LastName><ForeName>Madhav</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Clinical and Translational Neuroscience Unit, Laboratory of Behavioral Neuroscience, National Institute on Aging, Baltimore, MD, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dobson</LastName><ForeName>Richard J B</ForeName><Initials>RJB</Initials><AffiliationInfo><Affiliation>Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Powell</LastName><ForeName>John F</ForeName><Initials>JF</Initials><AffiliationInfo><Affiliation>Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lupton</LastName><ForeName>Michelle K</ForeName><Initials>MK</Initials><AffiliationInfo><Affiliation>Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Qld, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Simmons</LastName><ForeName>Andy</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>National Institute for Health Research (NIHR) Biomedical Research Centre (BRC) for Mental Health at South London and Maudsley NHS Foundation Trust, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Velayudhan</LastName><ForeName>Latha</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lovestone</LastName><ForeName>Simon</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, University of Oxford, Oxford, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Proitsi</LastName><ForeName>Petroula</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Legido-Quigley</LastName><ForeName>Cristina</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Institute of Pharmaceutical Science, King's College London, London, UK.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><Agency>Wellcome Trust</Agency><Country>United Kingdom</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>J Alzheimers Dis</MedlineTA><NlmUniqueID>9814863</NlmUniqueID><ISSNLinking>1387-2877</ISSNLinking></MedlineJournalInfo><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Neuroscience. 2005;130(3):657-66</RefSource><PMID Version="1">15590150</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Cereb Blood Flow Metab. 2016 Jul;36(7):1212-23</RefSource><PMID Version="1">26661209</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nature. 2014 May 22;509(7501):503-6</RefSource><PMID Version="1">24828044</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Alzheimers Dement. 2010 Sep;6(5):378-85</RefSource><PMID Version="1">20813340</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Alzheimers Dement. 2015 Mar;11(3):332-84</RefSource><PMID Version="1">25984581</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Alzheimers Dis. 2015;46(2):313-27</RefSource><PMID Version="1">25835424</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Aging Cell. 2012 Dec;11(6):960-7</RefSource><PMID Version="1">22834969</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurochem Int. 2006 Mar;48(4):286-95</RefSource><PMID Version="1">16434124</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Br J Nutr. 2003 Apr;89(4):483-9</RefSource><PMID Version="1">12654166</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS One. 2011;6(7):e21643</RefSource><PMID Version="1">21779331</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Anal Chem. 2012 Jul 17;84(14):5992-9</RefSource><PMID Version="1">22702345</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurobiol Dis. 2006 Jul;23 (1):178-89</RefSource><PMID Version="1">16626961</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Anal Chem. 2010 Dec 1;82(23):9858-64</RefSource><PMID Version="1">21062019</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Alzheimers Dement. 2017 Feb;13(2):140-151</RefSource><PMID Version="1">27693183</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Rev Cancer. 2013 Jan;13(1):51-65</RefSource><PMID Version="1">23235911</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Alzheimers Dement. 2016 Jul;12 (7):815-22</RefSource><PMID Version="1">26806385</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Rev Neurosci. 2015 Jan;16(1):30-42</RefSource><PMID Version="1">25524120</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS One. 2011;6(10):e24777</RefSource><PMID Version="1">22046234</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Rev Cancer. 2004 Aug;4(8):604-16</RefSource><PMID Version="1">15286740</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Biol Chem. 2012 Jan 20;287(4):2678-88</RefSource><PMID Version="1">22134919</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Med. 2014 Apr;20(4):415-8</RefSource><PMID Version="1">24608097</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Nutr Health Aging. 2007 Jul-Aug;11(4):359-61</RefSource><PMID Version="1">17653500</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Alzheimers Dis. 2012;29(3):537-47</RefSource><PMID Version="1">22258513</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurobiol Aging. 2007 Oct;28(10):1465-80</RefSource><PMID Version="1">16876913</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>JAMA Neurol. 2014 Jul 1;71(7):855-62</RefSource><PMID Version="1">24818585</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Biol Chem. 2003 May 30;278(22):19777-83</RefSource><PMID Version="1">12649271</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Alzheimers Dement. 2015 Sep;11(9):1007-14</RefSource><PMID Version="1">25681666</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Biochim Biophys Acta. 2014 Aug;1842(8):1232-9</RefSource><PMID Version="1">23816564</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Atherosclerosis. 2014 Aug;235(2):384-91</RefSource><PMID Version="1">24929287</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurology. 2013 May 7;80(19):1778-83</RefSource><PMID Version="1">23390181</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurobiol Aging. 2014 Feb;35(2):271-8</RefSource><PMID Version="1">24041970</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurology. 2012 Aug 14;79(7):633-41</RefSource><PMID Version="1">22815558</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 2004 Feb 17;101(7):2070-5</RefSource><PMID Version="1">14970312</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Transl Psychiatry. 2015 Jan 13;5:e494</RefSource><PMID Version="1">25585166</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Lancet Neurol. 2013 Feb;12(2):207-16</RefSource><PMID Version="1">23332364</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Altern Med Rev. 2007 Sep;12(3):207-27</RefSource><PMID Version="1">18072818</PMID></CommentsCorrections></CommentsCorrectionsList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Alzheimer’s disease</Keyword><Keyword MajorTopicYN="N">brain atrophy</Keyword><Keyword MajorTopicYN="N">ceramide</Keyword><Keyword MajorTopicYN="N">phosphatidylcholine</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>12</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>12</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>12</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27911300</ArticleId><ArticleId IdType="pii">JAD160645</ArticleId><ArticleId IdType="doi">10.3233/JAD-160645</ArticleId><ArticleId IdType="pmc">PMC5676755</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Australie</li><li>Finlande</li><li>France</li><li>Grèce</li><li>Italie</li><li>Pologne</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Grand Londres</li><li>Maryland</li><li>Midi-Pyrénées</li><li>Occitanie (région administrative)</li><li>Oxfordshire</li></region><settlement><li>Londres</li><li>Oxford</li><li>Toulouse</li></settlement><orgName><li>Université d'Oxford</li></orgName></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Kim, Min" sort="Kim, Min" uniqKey="Kim M" first="Min" last="Kim">Min Kim</name></region><name sortKey="Dobson, Richard J B" sort="Dobson, Richard J B" uniqKey="Dobson R" first="Richard J B" last="Dobson">Richard J B. Dobson</name><name sortKey="Legido Quigley, Cristina" sort="Legido Quigley, Cristina" uniqKey="Legido Quigley C" first="Cristina" last="Legido-Quigley">Cristina Legido-Quigley</name><name sortKey="Lovestone, Simon" sort="Lovestone, Simon" uniqKey="Lovestone S" first="Simon" last="Lovestone">Simon Lovestone</name><name sortKey="Nevado Holgado, Alejo" sort="Nevado Holgado, Alejo" uniqKey="Nevado Holgado A" first="Alejo" last="Nevado-Holgado">Alejo Nevado-Holgado</name><name sortKey="Powell, John F" sort="Powell, John F" uniqKey="Powell J" first="John F" last="Powell">John F. Powell</name><name sortKey="Proitsi, Petroula" sort="Proitsi, Petroula" uniqKey="Proitsi P" first="Petroula" last="Proitsi">Petroula Proitsi</name><name sortKey="Simmons, Andy" sort="Simmons, Andy" uniqKey="Simmons A" first="Andy" last="Simmons">Andy Simmons</name><name sortKey="Snowden, Stuart G" sort="Snowden, Stuart G" uniqKey="Snowden S" first="Stuart G" last="Snowden">Stuart G. Snowden</name><name sortKey="Velayudhan, Latha" sort="Velayudhan, Latha" uniqKey="Velayudhan L" first="Latha" last="Velayudhan">Latha Velayudhan</name><name sortKey="Whiley, Luke" sort="Whiley, Luke" uniqKey="Whiley L" first="Luke" last="Whiley">Luke Whiley</name></country><country name="Finlande"><noRegion><name sortKey="Soininen, Hilkka" sort="Soininen, Hilkka" uniqKey="Soininen H" first="Hilkka" last="Soininen">Hilkka Soininen</name></noRegion></country><country name="Pologne"><noRegion><name sortKey="Kloszewska, Iwona" sort="Kloszewska, Iwona" uniqKey="Kloszewska I" first="Iwona" last="Kloszewska">Iwona Kloszewska</name></noRegion></country><country name="Italie"><noRegion><name sortKey="Mecocci, Patrizia" sort="Mecocci, Patrizia" uniqKey="Mecocci P" first="Patrizia" last="Mecocci">Patrizia Mecocci</name></noRegion></country><country name="Grèce"><noRegion><name sortKey="Tsolaki, Magda" sort="Tsolaki, Magda" uniqKey="Tsolaki M" first="Magda" last="Tsolaki">Magda Tsolaki</name></noRegion></country><country name="France"><region name="Occitanie (région administrative)"><name sortKey="Vellas, Bruno" sort="Vellas, Bruno" uniqKey="Vellas B" first="Bruno" last="Vellas">Bruno Vellas</name></region></country><country name="États-Unis"><region name="Maryland"><name sortKey="Thambisetty, Madhav" sort="Thambisetty, Madhav" uniqKey="Thambisetty M" first="Madhav" last="Thambisetty">Madhav Thambisetty</name></region></country><country name="Australie"><noRegion><name sortKey="Lupton, Michelle K" sort="Lupton, Michelle K" uniqKey="Lupton M" first="Michelle K" last="Lupton">Michelle K. 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