Association between a common immunoglobulin heavy chain allele and rheumatic heart disease risk in Oceania.
Identifieur interne : 001159 ( PubMed/Checkpoint ); précédent : 001158; suivant : 001160Association between a common immunoglobulin heavy chain allele and rheumatic heart disease risk in Oceania.
Auteurs : Tom Parks [Royaume-Uni] ; Mariana M. Mirabel [France] ; Joseph Kado [Fidji] ; Kathryn Auckland [Royaume-Uni] ; Jaroslaw Nowak [Royaume-Uni] ; Anna Rautanen [Royaume-Uni] ; Alexander J. Mentzer [Royaume-Uni] ; Eloi Marijon [France] ; Xavier Jouven [France] ; Mai Ling Perman [Fidji] ; Tuliana Cua [Fidji] ; John K. Kauwe [États-Unis] ; John B. Allen [États-Unis] ; Henry Taylor [Samoa] ; Kathryn J. Robson [Royaume-Uni] ; Charlotte M. Deane [Royaume-Uni] ; Andrew C. Steer [Australie] ; Adrian V S. Hill [Royaume-Uni]Source :
- Nature communications [ 2041-1723 ] ; 2017.
Abstract
The indigenous populations of the South Pacific experience a high burden of rheumatic heart disease (RHD). Here we report a genome-wide association study (GWAS) of RHD susceptibility in 2,852 individuals recruited in eight Oceanian countries. Stratifying by ancestry, we analysed genotyped and imputed variants in Melanesians (607 cases and 1,229 controls) before follow-up of suggestive loci in three further ancestral groups: Polynesians, South Asians and Mixed or other populations (totalling 399 cases and 617 controls). We identify a novel susceptibility signal in the immunoglobulin heavy chain (IGH) locus centring on a haplotype of nonsynonymous variants in the IGHV4-61 gene segment corresponding to the IGHV4-61*02 allele. We show each copy of IGHV4-61*02 is associated with a 1.4-fold increase in the risk of RHD (odds ratio 1.43, 95% confidence intervals 1.27-1.61, P=4.1 × 10(-9)). These findings provide new insight into the role of germline variation in the IGH locus in disease susceptibility.
DOI: 10.1038/ncomms14946
PubMed: 28492228
Affiliations:
- Australie, Fidji, France, Royaume-Uni, Samoa, États-Unis
- Angleterre, Oxfordshire, Victoria (État), Île-de-France
- Melbourne, Oxford, Paris
- Université d'Oxford, Université de Melbourne
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Mirabel</name><affiliation wicri:level="1"><nlm:affiliation>Paris Centre de Recherche Cardiovasculaire, Institut National de la Santé et de la Recherche Médicale, Hôpital Européen Georges Pompidou, 56, rue Leblanc, 75908 Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Paris Centre de Recherche Cardiovasculaire, Institut National de la Santé et de la Recherche Médicale, Hôpital Européen Georges Pompidou, 56, rue Leblanc, 75908 Paris</wicri:regionArea><wicri:noRegion>75908 Paris</wicri:noRegion><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Kado, Joseph" sort="Kado, Joseph" uniqKey="Kado J" first="Joseph" last="Kado">Joseph Kado</name><affiliation wicri:level="1"><nlm:affiliation>Department of Paediatrics, Ministry of Health and Medical Services, Colonial War Memorial Hospital, Brown Street, Suva, Fiji.</nlm:affiliation><country xml:lang="fr">Fidji</country><wicri:regionArea>Department of Paediatrics, Ministry of Health and Medical Services, Colonial War Memorial Hospital, Brown Street, Suva</wicri:regionArea><wicri:noRegion>Suva</wicri:noRegion></affiliation></author><author><name sortKey="Auckland, Kathryn" sort="Auckland, Kathryn" uniqKey="Auckland K" first="Kathryn" last="Auckland">Kathryn Auckland</name><affiliation wicri:level="4"><nlm:affiliation>Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN</wicri:regionArea><orgName type="university">Université d'Oxford</orgName><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Nowak, Jaroslaw" sort="Nowak, Jaroslaw" uniqKey="Nowak J" first="Jaroslaw" last="Nowak">Jaroslaw Nowak</name><affiliation wicri:level="4"><nlm:affiliation>Department of Statistics, University of Oxford, Peter Medawar Building for Pathogen Research, Oxford OX1 3S, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Statistics, University of Oxford, Peter Medawar Building for Pathogen Research, Oxford OX1 3S</wicri:regionArea><orgName type="university">Université d'Oxford</orgName><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Rautanen, Anna" sort="Rautanen, Anna" uniqKey="Rautanen A" first="Anna" last="Rautanen">Anna Rautanen</name><affiliation wicri:level="4"><nlm:affiliation>Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN</wicri:regionArea><orgName type="university">Université d'Oxford</orgName><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Mentzer, Alexander J" sort="Mentzer, Alexander J" uniqKey="Mentzer A" first="Alexander J" last="Mentzer">Alexander J. Mentzer</name><affiliation wicri:level="4"><nlm:affiliation>Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN</wicri:regionArea><orgName type="university">Université d'Oxford</orgName><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Marijon, Eloi" sort="Marijon, Eloi" uniqKey="Marijon E" first="Eloi" last="Marijon">Eloi Marijon</name><affiliation wicri:level="1"><nlm:affiliation>Paris Centre de Recherche Cardiovasculaire, Institut National de la Santé et de la Recherche Médicale, Hôpital Européen Georges Pompidou, 56, rue Leblanc, 75908 Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Paris Centre de Recherche Cardiovasculaire, Institut National de la Santé et de la Recherche Médicale, Hôpital Européen Georges Pompidou, 56, rue Leblanc, 75908 Paris</wicri:regionArea><wicri:noRegion>75908 Paris</wicri:noRegion><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Jouven, Xavier" sort="Jouven, Xavier" uniqKey="Jouven X" first="Xavier" last="Jouven">Xavier Jouven</name><affiliation wicri:level="1"><nlm:affiliation>Paris Centre de Recherche Cardiovasculaire, Institut National de la Santé et de la Recherche Médicale, Hôpital Européen Georges Pompidou, 56, rue Leblanc, 75908 Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Paris Centre de Recherche Cardiovasculaire, Institut National de la Santé et de la Recherche Médicale, Hôpital Européen Georges Pompidou, 56, rue Leblanc, 75908 Paris</wicri:regionArea><wicri:noRegion>75908 Paris</wicri:noRegion><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Perman, Mai Ling" sort="Perman, Mai Ling" uniqKey="Perman M" first="Mai Ling" last="Perman">Mai Ling Perman</name><affiliation wicri:level="1"><nlm:affiliation>College of Medicine, Nursing &Health Sciences, Fiji National University, Brown Street, Suva, Fiji.</nlm:affiliation><country xml:lang="fr">Fidji</country><wicri:regionArea>College of Medicine, Nursing &Health Sciences, Fiji National University, Brown Street, Suva</wicri:regionArea><wicri:noRegion>Suva</wicri:noRegion></affiliation></author><author><name sortKey="Cua, Tuliana" sort="Cua, Tuliana" uniqKey="Cua T" first="Tuliana" last="Cua">Tuliana Cua</name><affiliation wicri:level="1"><nlm:affiliation>Rheumatic Heart Disease Control Programme, Ministry of Health and Medical Services, Colonial War Memorial Hospital, Brown Street, Suva, Fiji.</nlm:affiliation><country xml:lang="fr">Fidji</country><wicri:regionArea>Rheumatic Heart Disease Control Programme, Ministry of Health and Medical Services, Colonial War Memorial Hospital, Brown Street, Suva</wicri:regionArea><wicri:noRegion>Suva</wicri:noRegion></affiliation></author><author><name sortKey="Kauwe, John K" sort="Kauwe, John K" uniqKey="Kauwe J" first="John K" last="Kauwe">John K. Kauwe</name><affiliation wicri:level="1"><nlm:affiliation>College of Life Sciences, Brigham Young University, 4146 Life Sciences Building, Provo, Utah 84602, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>College of Life Sciences, Brigham Young University, 4146 Life Sciences Building, Provo, Utah 84602</wicri:regionArea><wicri:noRegion>Utah 84602</wicri:noRegion></affiliation></author><author><name sortKey="Allen, John B" sort="Allen, John B" uniqKey="Allen J" first="John B" last="Allen">John B. Allen</name><affiliation wicri:level="1"><nlm:affiliation>College of Life Sciences, Brigham Young University, 4146 Life Sciences Building, Provo, Utah 84602, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>College of Life Sciences, Brigham Young University, 4146 Life Sciences Building, Provo, Utah 84602</wicri:regionArea><wicri:noRegion>Utah 84602</wicri:noRegion></affiliation></author><author><name sortKey="Taylor, Henry" sort="Taylor, Henry" uniqKey="Taylor H" first="Henry" last="Taylor">Henry Taylor</name><affiliation wicri:level="1"><nlm:affiliation>Rheumatic Heart Disease Control Programme, Samoa Ministry of Health, Moto'otua, Ifiifi Street, Apia, Samoa.</nlm:affiliation><country xml:lang="fr">Samoa</country><wicri:regionArea>Rheumatic Heart Disease Control Programme, Samoa Ministry of Health, Moto'otua, Ifiifi Street, Apia</wicri:regionArea><wicri:noRegion>Apia</wicri:noRegion></affiliation></author><author><name sortKey="Robson, Kathryn J" sort="Robson, Kathryn J" uniqKey="Robson K" first="Kathryn J" last="Robson">Kathryn J. Robson</name><affiliation wicri:level="4"><nlm:affiliation>MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DS</wicri:regionArea><orgName type="university">Université d'Oxford</orgName><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Deane, Charlotte M" sort="Deane, Charlotte M" uniqKey="Deane C" first="Charlotte M" last="Deane">Charlotte M. Deane</name><affiliation wicri:level="4"><nlm:affiliation>Department of Statistics, University of Oxford, Peter Medawar Building for Pathogen Research, Oxford OX1 3S, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Statistics, University of Oxford, Peter Medawar Building for Pathogen Research, Oxford OX1 3S</wicri:regionArea><orgName type="university">Université d'Oxford</orgName><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Steer, Andrew C" sort="Steer, Andrew C" uniqKey="Steer A" first="Andrew C" last="Steer">Andrew C. Steer</name><affiliation wicri:level="4"><nlm:affiliation>Centre for International Child Health, University of Melbourne, 50 Flemington Road, Parkville, Melbourne Victoria 3052, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for International Child Health, University of Melbourne, 50 Flemington Road, Parkville, Melbourne Victoria 3052</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Hill, Adrian V S" sort="Hill, Adrian V S" uniqKey="Hill A" first="Adrian V S" last="Hill">Adrian V S. Hill</name><affiliation wicri:level="4"><nlm:affiliation>Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN</wicri:regionArea><orgName type="university">Université d'Oxford</orgName><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation></author></analytic><series><title level="j">Nature communications</title><idno type="eISSN">2041-1723</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The indigenous populations of the South Pacific experience a high burden of rheumatic heart disease (RHD). Here we report a genome-wide association study (GWAS) of RHD susceptibility in 2,852 individuals recruited in eight Oceanian countries. Stratifying by ancestry, we analysed genotyped and imputed variants in Melanesians (607 cases and 1,229 controls) before follow-up of suggestive loci in three further ancestral groups: Polynesians, South Asians and Mixed or other populations (totalling 399 cases and 617 controls). We identify a novel susceptibility signal in the immunoglobulin heavy chain (IGH) locus centring on a haplotype of nonsynonymous variants in the IGHV4-61 gene segment corresponding to the IGHV4-61*02 allele. We show each copy of IGHV4-61*02 is associated with a 1.4-fold increase in the risk of RHD (odds ratio 1.43, 95% confidence intervals 1.27-1.61, P=4.1 × 10(-9)). These findings provide new insight into the role of germline variation in the IGH locus in disease susceptibility.</div></front></TEI><pubmed><MedlineCitation Status="In-Data-Review" Owner="NLM"><PMID Version="1">28492228</PMID><DateCreated><Year>2017</Year><Month>05</Month><Day>11</Day></DateCreated><DateRevised><Year>2017</Year><Month>06</Month><Day>03</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">2041-1723</ISSN><JournalIssue CitedMedium="Internet"><Volume>8</Volume><PubDate><Year>2017</Year><Month>May</Month><Day>11</Day></PubDate></JournalIssue><Title>Nature communications</Title><ISOAbbreviation>Nat Commun</ISOAbbreviation></Journal><ArticleTitle>Association between a common immunoglobulin heavy chain allele and rheumatic heart disease risk in Oceania.</ArticleTitle><Pagination><MedlinePgn>14946</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1038/ncomms14946</ELocationID><Abstract><AbstractText>The indigenous populations of the South Pacific experience a high burden of rheumatic heart disease (RHD). Here we report a genome-wide association study (GWAS) of RHD susceptibility in 2,852 individuals recruited in eight Oceanian countries. Stratifying by ancestry, we analysed genotyped and imputed variants in Melanesians (607 cases and 1,229 controls) before follow-up of suggestive loci in three further ancestral groups: Polynesians, South Asians and Mixed or other populations (totalling 399 cases and 617 controls). We identify a novel susceptibility signal in the immunoglobulin heavy chain (IGH) locus centring on a haplotype of nonsynonymous variants in the IGHV4-61 gene segment corresponding to the IGHV4-61*02 allele. We show each copy of IGHV4-61*02 is associated with a 1.4-fold increase in the risk of RHD (odds ratio 1.43, 95% confidence intervals 1.27-1.61, P=4.1 × 10(-9)). These findings provide new insight into the role of germline variation in the IGH locus in disease susceptibility.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Parks</LastName><ForeName>Tom</ForeName><Initials>T</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-1163-8654</Identifier><AffiliationInfo><Affiliation>Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mirabel</LastName><ForeName>Mariana M</ForeName><Initials>MM</Initials><AffiliationInfo><Affiliation>Paris Centre de Recherche Cardiovasculaire, Institut National de la Santé et de la Recherche Médicale, Hôpital Européen Georges Pompidou, 56, rue Leblanc, 75908 Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kado</LastName><ForeName>Joseph</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Paediatrics, Ministry of Health and Medical Services, Colonial War Memorial Hospital, Brown Street, Suva, Fiji.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>College of Medicine, Nursing &Health Sciences, Fiji National University, Brown Street, Suva, Fiji.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Auckland</LastName><ForeName>Kathryn</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nowak</LastName><ForeName>Jaroslaw</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Statistics, University of Oxford, Peter Medawar Building for Pathogen Research, Oxford OX1 3S, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rautanen</LastName><ForeName>Anna</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mentzer</LastName><ForeName>Alexander J</ForeName><Initials>AJ</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-4502-2209</Identifier><AffiliationInfo><Affiliation>Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Marijon</LastName><ForeName>Eloi</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Paris Centre de Recherche Cardiovasculaire, Institut National de la Santé et de la Recherche Médicale, Hôpital Européen Georges Pompidou, 56, rue Leblanc, 75908 Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Faculté de Médecine Paris Descartes, Université Paris Descartes, 15, rue de l'école de medicine, 75006 Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jouven</LastName><ForeName>Xavier</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Paris Centre de Recherche Cardiovasculaire, Institut National de la Santé et de la Recherche Médicale, Hôpital Européen Georges Pompidou, 56, rue Leblanc, 75908 Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Faculté de Médecine Paris Descartes, Université Paris Descartes, 15, rue de l'école de medicine, 75006 Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Perman</LastName><ForeName>Mai Ling</ForeName><Initials>ML</Initials><AffiliationInfo><Affiliation>College of Medicine, Nursing &Health Sciences, Fiji National University, Brown Street, Suva, Fiji.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cua</LastName><ForeName>Tuliana</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Rheumatic Heart Disease Control Programme, Ministry of Health and Medical Services, Colonial War Memorial Hospital, Brown Street, Suva, Fiji.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kauwe</LastName><ForeName>John K</ForeName><Initials>JK</Initials><AffiliationInfo><Affiliation>College of Life Sciences, Brigham Young University, 4146 Life Sciences Building, Provo, Utah 84602, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Allen</LastName><ForeName>John B</ForeName><Initials>JB</Initials><AffiliationInfo><Affiliation>College of Life Sciences, Brigham Young University, 4146 Life Sciences Building, Provo, Utah 84602, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Taylor</LastName><ForeName>Henry</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Rheumatic Heart Disease Control Programme, Samoa Ministry of Health, Moto'otua, Ifiifi Street, Apia, Samoa.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Robson</LastName><ForeName>Kathryn J</ForeName><Initials>KJ</Initials><AffiliationInfo><Affiliation>MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Deane</LastName><ForeName>Charlotte M</ForeName><Initials>CM</Initials><Identifier Source="ORCID">http://orcid.org/0000-0003-1388-2252</Identifier><AffiliationInfo><Affiliation>Department of Statistics, University of Oxford, Peter Medawar Building for Pathogen Research, Oxford OX1 3S, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Steer</LastName><ForeName>Andrew C</ForeName><Initials>AC</Initials><AffiliationInfo><Affiliation>Centre for International Child Health, University of Melbourne, 50 Flemington Road, Parkville, Melbourne Victoria 3052, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Murdoch Children's Research Institute, 50 Flemington Road, Parkville, Melbourne, Victoria 3052, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hill</LastName><ForeName>Adrian V S</ForeName><Initials>AVS</Initials><AffiliationInfo><Affiliation>Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>Pacific Islands Rheumatic Heart Disease Genetics Network</CollectiveName></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><Agency>Wellcome Trust</Agency><Country>United Kingdom</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>05</Month><Day>11</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Nat 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ValidYN="Y"><LastName>Braunstein</LastName><ForeName>Corinne</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Colquhoun</LastName><ForeName>Samantha M</ForeName><Initials>SM</Initials></Investigator><Investigator ValidYN="Y"><LastName>Jewine</LastName><ForeName>Aurélia</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ah Kee</LastName><ForeName>Maureen</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Kumar</LastName><ForeName>Rina</ForeName><Initials>R</Initials></Investigator><Investigator ValidYN="Y"><LastName>John Martin</LastName><ForeName>William</ForeName><Initials>W</Initials></Investigator><Investigator ValidYN="Y"><LastName>Mataika</LastName><ForeName>Reapi</ForeName><Initials>R</Initials></Investigator><Investigator ValidYN="Y"><LastName>Nadra</LastName><ForeName>Marie</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Nadu</LastName><ForeName>Shahin</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Naseri</LastName><ForeName>Take</ForeName><Initials>T</Initials></Investigator><Investigator ValidYN="Y"><LastName>Noël</LastName><ForeName>Baptiste</ForeName><Initials>B</Initials></Investigator><Investigator ValidYN="Y"><LastName>Simon</LastName><ForeName>Nathalie</ForeName><Initials>N</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ward</LastName><ForeName>Brenton</ForeName><Initials>B</Initials></Investigator></InvestigatorList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>09</Month><Day>15</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2017</Year><Month>02</Month><Day>15</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>5</Month><Day>12</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>5</Month><Day>12</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>5</Month><Day>12</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">28492228</ArticleId><ArticleId IdType="pii">ncomms14946</ArticleId><ArticleId IdType="doi">10.1038/ncomms14946</ArticleId><ArticleId IdType="pmc">PMC5437274</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Australie</li><li>Fidji</li><li>France</li><li>Royaume-Uni</li><li>Samoa</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Oxfordshire</li><li>Victoria (État)</li><li>Île-de-France</li></region><settlement><li>Melbourne</li><li>Oxford</li><li>Paris</li></settlement><orgName><li>Université d'Oxford</li><li>Université de Melbourne</li></orgName></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Parks, Tom" sort="Parks, Tom" uniqKey="Parks T" first="Tom" last="Parks">Tom Parks</name></region><name sortKey="Auckland, Kathryn" sort="Auckland, Kathryn" uniqKey="Auckland K" first="Kathryn" last="Auckland">Kathryn Auckland</name><name sortKey="Deane, Charlotte M" sort="Deane, Charlotte M" uniqKey="Deane C" first="Charlotte M" last="Deane">Charlotte M. Deane</name><name sortKey="Hill, Adrian V S" sort="Hill, Adrian V S" uniqKey="Hill A" first="Adrian V S" last="Hill">Adrian V S. Hill</name><name sortKey="Mentzer, Alexander J" sort="Mentzer, Alexander J" uniqKey="Mentzer A" first="Alexander J" last="Mentzer">Alexander J. Mentzer</name><name sortKey="Nowak, Jaroslaw" sort="Nowak, Jaroslaw" uniqKey="Nowak J" first="Jaroslaw" last="Nowak">Jaroslaw Nowak</name><name sortKey="Rautanen, Anna" sort="Rautanen, Anna" uniqKey="Rautanen A" first="Anna" last="Rautanen">Anna Rautanen</name><name sortKey="Robson, Kathryn J" sort="Robson, Kathryn J" uniqKey="Robson K" first="Kathryn J" last="Robson">Kathryn J. Robson</name></country><country name="France"><region name="Île-de-France"><name sortKey="Mirabel, Mariana M" sort="Mirabel, Mariana M" uniqKey="Mirabel M" first="Mariana M" last="Mirabel">Mariana M. Mirabel</name></region><name sortKey="Jouven, Xavier" sort="Jouven, Xavier" uniqKey="Jouven X" first="Xavier" last="Jouven">Xavier Jouven</name><name sortKey="Marijon, Eloi" sort="Marijon, Eloi" uniqKey="Marijon E" first="Eloi" last="Marijon">Eloi Marijon</name></country><country name="Fidji"><noRegion><name sortKey="Kado, Joseph" sort="Kado, Joseph" uniqKey="Kado J" first="Joseph" last="Kado">Joseph Kado</name></noRegion><name sortKey="Cua, Tuliana" sort="Cua, Tuliana" uniqKey="Cua T" first="Tuliana" last="Cua">Tuliana Cua</name><name sortKey="Perman, Mai Ling" sort="Perman, Mai Ling" uniqKey="Perman M" first="Mai Ling" last="Perman">Mai Ling Perman</name></country><country name="États-Unis"><noRegion><name sortKey="Kauwe, John K" sort="Kauwe, John K" uniqKey="Kauwe J" first="John K" last="Kauwe">John K. Kauwe</name></noRegion><name sortKey="Allen, John B" sort="Allen, John B" uniqKey="Allen J" first="John B" last="Allen">John B. Allen</name></country><country name="Samoa"><noRegion><name sortKey="Taylor, Henry" sort="Taylor, Henry" uniqKey="Taylor H" first="Henry" last="Taylor">Henry Taylor</name></noRegion></country><country name="Australie"><region name="Victoria (État)"><name sortKey="Steer, Andrew C" sort="Steer, Andrew C" uniqKey="Steer A" first="Andrew C" last="Steer">Andrew C. Steer</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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