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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Malagasy Genetic Ancestry Comes from an Historical Malay Trading Post in Southeast Borneo</title><author><name sortKey="Brucato, Nicolas" sort="Brucato, Nicolas" uniqKey="Brucato N" first="Nicolas" last="Brucato">Nicolas Brucato</name><affiliation><nlm:aff id="msw117-aff1">Evolutionary Medicine Group, Laboratoire d’Anthropologie Moléculaire et Imagerie de Synthèse UMR 5288 CNRS, Université Toulouse III, Université de Toulouse, Toulouse, France</nlm:aff></affiliation></author><author><name sortKey="Kusuma, Pradiptajati" sort="Kusuma, Pradiptajati" uniqKey="Kusuma P" first="Pradiptajati" last="Kusuma">Pradiptajati Kusuma</name><affiliation><nlm:aff id="msw117-aff1">Evolutionary Medicine Group, Laboratoire d’Anthropologie Moléculaire et Imagerie de Synthèse UMR 5288 CNRS, Université Toulouse III, Université de Toulouse, Toulouse, France</nlm:aff></affiliation><affiliation><nlm:aff id="msw117-aff2">Genome Diversity and Diseases Laboratory, Eijkman Institute for Molecular Biology, Jakarta, Indonesia</nlm:aff></affiliation></author><author><name sortKey="Cox, Murray P" sort="Cox, Murray P" uniqKey="Cox M" first="Murray P." last="Cox">Murray P. Cox</name><affiliation><nlm:aff id="msw117-aff3">Statistics and Bioinformatics Group, Institute of Fundamental Sciences, Massey University, Palmerston North, New Zealand</nlm:aff></affiliation></author><author><name sortKey="Pierron, Denis" sort="Pierron, Denis" uniqKey="Pierron D" first="Denis" last="Pierron">Denis Pierron</name><affiliation><nlm:aff id="msw117-aff1">Evolutionary Medicine Group, Laboratoire d’Anthropologie Moléculaire et Imagerie de Synthèse UMR 5288 CNRS, Université Toulouse III, Université de Toulouse, Toulouse, France</nlm:aff></affiliation></author><author><name sortKey="Purnomo, Gludhug A" sort="Purnomo, Gludhug A" uniqKey="Purnomo G" first="Gludhug A." last="Purnomo">Gludhug A. Purnomo</name><affiliation><nlm:aff id="msw117-aff2">Genome Diversity and Diseases Laboratory, Eijkman Institute for Molecular Biology, Jakarta, Indonesia</nlm:aff></affiliation></author><author><name sortKey="Adelaar, Alexander" sort="Adelaar, Alexander" uniqKey="Adelaar A" first="Alexander" last="Adelaar">Alexander Adelaar</name><affiliation><nlm:aff id="msw117-aff4">Asia Institute, University of Melbourne, Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Kivisild, Toomas" sort="Kivisild, Toomas" uniqKey="Kivisild T" first="Toomas" last="Kivisild">Toomas Kivisild</name><affiliation><nlm:aff id="msw117-aff5">Department of Biological Anthropology, University of Cambridge, Cambridge, United Kingdom</nlm:aff></affiliation><affiliation><nlm:aff id="msw117-aff6">Estonian Biocentre, Tartu, Estonia</nlm:aff></affiliation></author><author><name sortKey="Letellier, Thierry" sort="Letellier, Thierry" uniqKey="Letellier T" first="Thierry" last="Letellier">Thierry Letellier</name><affiliation><nlm:aff id="msw117-aff1">Evolutionary Medicine Group, Laboratoire d’Anthropologie Moléculaire et Imagerie de Synthèse UMR 5288 CNRS, Université Toulouse III, Université de Toulouse, Toulouse, France</nlm:aff></affiliation></author><author><name sortKey="Sudoyo, Herawati" sort="Sudoyo, Herawati" uniqKey="Sudoyo H" first="Herawati" last="Sudoyo">Herawati Sudoyo</name><affiliation><nlm:aff id="msw117-aff2">Genome Diversity and Diseases Laboratory, Eijkman Institute for Molecular Biology, Jakarta, Indonesia</nlm:aff></affiliation><affiliation><nlm:aff id="msw117-aff7">Department of Medical Biology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia</nlm:aff></affiliation></author><author><name sortKey="Ricaut, Francois Xavier" sort="Ricaut, Francois Xavier" uniqKey="Ricaut F" first="François-Xavier" last="Ricaut">François-Xavier Ricaut</name><affiliation><nlm:aff id="msw117-aff1">Evolutionary Medicine Group, Laboratoire d’Anthropologie Moléculaire et Imagerie de Synthèse UMR 5288 CNRS, Université Toulouse III, Université de Toulouse, Toulouse, France</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27381999</idno><idno type="pmc">4989113</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4989113</idno><idno type="RBID">PMC:4989113</idno><idno type="doi">10.1093/molbev/msw117</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">002765</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002765</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Malagasy Genetic Ancestry Comes from an Historical Malay Trading Post in Southeast Borneo</title><author><name sortKey="Brucato, Nicolas" sort="Brucato, Nicolas" uniqKey="Brucato N" first="Nicolas" last="Brucato">Nicolas Brucato</name><affiliation><nlm:aff id="msw117-aff1">Evolutionary Medicine Group, Laboratoire d’Anthropologie Moléculaire et Imagerie de Synthèse UMR 5288 CNRS, Université Toulouse III, Université de Toulouse, Toulouse, France</nlm:aff></affiliation></author><author><name sortKey="Kusuma, Pradiptajati" sort="Kusuma, Pradiptajati" uniqKey="Kusuma P" first="Pradiptajati" last="Kusuma">Pradiptajati Kusuma</name><affiliation><nlm:aff id="msw117-aff1">Evolutionary Medicine Group, Laboratoire d’Anthropologie Moléculaire et Imagerie de Synthèse UMR 5288 CNRS, Université Toulouse III, Université de Toulouse, Toulouse, France</nlm:aff></affiliation><affiliation><nlm:aff id="msw117-aff2">Genome Diversity and Diseases Laboratory, Eijkman Institute for Molecular Biology, Jakarta, Indonesia</nlm:aff></affiliation></author><author><name sortKey="Cox, Murray P" sort="Cox, Murray P" uniqKey="Cox M" first="Murray P." last="Cox">Murray P. Cox</name><affiliation><nlm:aff id="msw117-aff3">Statistics and Bioinformatics Group, Institute of Fundamental Sciences, Massey University, Palmerston North, New Zealand</nlm:aff></affiliation></author><author><name sortKey="Pierron, Denis" sort="Pierron, Denis" uniqKey="Pierron D" first="Denis" last="Pierron">Denis Pierron</name><affiliation><nlm:aff id="msw117-aff1">Evolutionary Medicine Group, Laboratoire d’Anthropologie Moléculaire et Imagerie de Synthèse UMR 5288 CNRS, Université Toulouse III, Université de Toulouse, Toulouse, France</nlm:aff></affiliation></author><author><name sortKey="Purnomo, Gludhug A" sort="Purnomo, Gludhug A" uniqKey="Purnomo G" first="Gludhug A." last="Purnomo">Gludhug A. Purnomo</name><affiliation><nlm:aff id="msw117-aff2">Genome Diversity and Diseases Laboratory, Eijkman Institute for Molecular Biology, Jakarta, Indonesia</nlm:aff></affiliation></author><author><name sortKey="Adelaar, Alexander" sort="Adelaar, Alexander" uniqKey="Adelaar A" first="Alexander" last="Adelaar">Alexander Adelaar</name><affiliation><nlm:aff id="msw117-aff4">Asia Institute, University of Melbourne, Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Kivisild, Toomas" sort="Kivisild, Toomas" uniqKey="Kivisild T" first="Toomas" last="Kivisild">Toomas Kivisild</name><affiliation><nlm:aff id="msw117-aff5">Department of Biological Anthropology, University of Cambridge, Cambridge, United Kingdom</nlm:aff></affiliation><affiliation><nlm:aff id="msw117-aff6">Estonian Biocentre, Tartu, Estonia</nlm:aff></affiliation></author><author><name sortKey="Letellier, Thierry" sort="Letellier, Thierry" uniqKey="Letellier T" first="Thierry" last="Letellier">Thierry Letellier</name><affiliation><nlm:aff id="msw117-aff1">Evolutionary Medicine Group, Laboratoire d’Anthropologie Moléculaire et Imagerie de Synthèse UMR 5288 CNRS, Université Toulouse III, Université de Toulouse, Toulouse, France</nlm:aff></affiliation></author><author><name sortKey="Sudoyo, Herawati" sort="Sudoyo, Herawati" uniqKey="Sudoyo H" first="Herawati" last="Sudoyo">Herawati Sudoyo</name><affiliation><nlm:aff id="msw117-aff2">Genome Diversity and Diseases Laboratory, Eijkman Institute for Molecular Biology, Jakarta, Indonesia</nlm:aff></affiliation><affiliation><nlm:aff id="msw117-aff7">Department of Medical Biology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia</nlm:aff></affiliation></author><author><name sortKey="Ricaut, Francois Xavier" sort="Ricaut, Francois Xavier" uniqKey="Ricaut F" first="François-Xavier" last="Ricaut">François-Xavier Ricaut</name><affiliation><nlm:aff id="msw117-aff1">Evolutionary Medicine Group, Laboratoire d’Anthropologie Moléculaire et Imagerie de Synthèse UMR 5288 CNRS, Université Toulouse III, Université de Toulouse, Toulouse, France</nlm:aff></affiliation></author></analytic><series><title level="j">Molecular Biology and Evolution</title><idno type="ISSN">0737-4038</idno><idno type="eISSN">1537-1719</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Malagasy genetic diversity results from an exceptional protoglobalization process that took place over a thousand years ago across the Indian Ocean. Previous efforts to locate the Asian origin of Malagasy highlighted Borneo broadly as a potential source, but so far no firm source populations were identified. Here, we have generated genome-wide data from two Southeast Borneo populations, the Banjar and the Ngaju, together with published data from populations across the Indian Ocean region. We find strong support for an origin of the Asian ancestry of Malagasy among the Banjar. This group emerged from the long-standing presence of a Malay Empire trading post in Southeast Borneo, which favored admixture between the Malay and an autochthonous Borneo group, the Ma’anyan. Reconciling genetic, historical, and linguistic data, we show that the Banjar, in Malay-led voyages, were the most probable Asian source among the analyzed groups in the founding of the Malagasy gene pool.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Adelaar, Ka" uniqKey="Adelaar K">KA. Adelaar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Adelaar, Ka" uniqKey="Adelaar K">KA. Adelaar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Adelaar, Ka" uniqKey="Adelaar K">KA. Adelaar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Adelaar, Ka" uniqKey="Adelaar K">KA. Adelaar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Adelaar, Ka" uniqKey="Adelaar K">KA. Adelaar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Alexander, Dh" uniqKey="Alexander D">DH Alexander</name></author><author><name sortKey="Novembre, J" uniqKey="Novembre J">J Novembre</name></author><author><name sortKey="Lange, K" uniqKey="Lange K">K. Lange</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Beaujard, P" uniqKey="Beaujard P">P. Beaujard</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Beaujard, P" uniqKey="Beaujard P">P. Beaujard</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brisbin, A" uniqKey="Brisbin A">A Brisbin</name></author><author><name sortKey="Bryc, K" uniqKey="Bryc K">K Bryc</name></author><author><name sortKey="Byrnes, J" uniqKey="Byrnes J">J Byrnes</name></author><author><name sortKey="Zakharia, F" uniqKey="Zakharia F">F Zakharia</name></author><author><name sortKey="Omberg, L" uniqKey="Omberg L">L Omberg</name></author><author><name sortKey="Degenhardt, J" uniqKey="Degenhardt J">J Degenhardt</name></author><author><name sortKey="Reynolds, A" uniqKey="Reynolds A">A Reynolds</name></author><author><name sortKey="Ostrer, H" uniqKey="Ostrer H">H Ostrer</name></author><author><name sortKey="Mezey, Jg" uniqKey="Mezey J">JG Mezey</name></author><author><name sortKey="Bustamante, Cd" uniqKey="Bustamante C">CD. Bustamante</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Capredon, M" uniqKey="Capredon M">M Capredon</name></author><author><name sortKey="Brucato, N" uniqKey="Brucato N">N Brucato</name></author><author><name sortKey="Tonasso, L" uniqKey="Tonasso L">L Tonasso</name></author><author><name sortKey="Choesmel Cadamuro, V" uniqKey="Choesmel Cadamuro V">V Choesmel-Cadamuro</name></author><author><name sortKey="Ricaut, F X" uniqKey="Ricaut F">F-X Ricaut</name></author><author><name sortKey="Razafindrazaka, H" uniqKey="Razafindrazaka H">H Razafindrazaka</name></author><author><name sortKey="Rakotondrabe, Ab" uniqKey="Rakotondrabe A">AB Rakotondrabe</name></author><author><name sortKey="Ratolojanahary, Ma" uniqKey="Ratolojanahary M">MA Ratolojanahary</name></author><author><name sortKey="Randriamarolaza, L P" uniqKey="Randriamarolaza L">L-P Randriamarolaza</name></author><author><name sortKey="Champion, B" uniqKey="Champion B">B Champion</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cox, Mp" uniqKey="Cox M">MP Cox</name></author><author><name sortKey="Nelson, Mg" uniqKey="Nelson M">MG Nelson</name></author><author><name sortKey="Tumonggor, Mk" uniqKey="Tumonggor M">MK Tumonggor</name></author><author><name sortKey="Ricaut, F X" uniqKey="Ricaut F">F-X Ricaut</name></author><author><name sortKey="Sudoyo, H" uniqKey="Sudoyo H">H. Sudoyo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dahl, Oc" uniqKey="Dahl O">OC. Dahl</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dahl, Oc" uniqKey="Dahl O">OC. Dahl</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dewar, Re" uniqKey="Dewar R">RE Dewar</name></author><author><name sortKey="Wright, Ht" uniqKey="Wright H">HT. Wright</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fourquet, R" uniqKey="Fourquet R">R Fourquet</name></author><author><name sortKey="Sarthou, J" uniqKey="Sarthou J">J Sarthou</name></author><author><name sortKey="Roux, J" uniqKey="Roux J">J Roux</name></author><author><name sortKey="Aori, K" uniqKey="Aori K">K. Aori</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fuller, Dq" uniqKey="Fuller D">DQ Fuller</name></author><author><name sortKey="Boivin, N" uniqKey="Boivin N">N Boivin</name></author><author><name sortKey="Hoogervorst, T" uniqKey="Hoogervorst T">T Hoogervorst</name></author><author><name sortKey="Allaby, R" uniqKey="Allaby R">R. Allaby</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hellenthal, G" uniqKey="Hellenthal G">G Hellenthal</name></author><author><name sortKey="Busby, Gb" uniqKey="Busby G">GB Busby</name></author><author><name sortKey="Band, G" uniqKey="Band G">G Band</name></author><author><name sortKey="Wilson, Jf" uniqKey="Wilson J">JF Wilson</name></author><author><name sortKey="Capelli, C" uniqKey="Capelli C">C Capelli</name></author><author><name sortKey="Falush, D" uniqKey="Falush D">D Falush</name></author><author><name sortKey="Myers, S" uniqKey="Myers S">S. Myers</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hewitt, R" uniqKey="Hewitt R">R Hewitt</name></author><author><name sortKey="Krause, A" uniqKey="Krause A">A Krause</name></author><author><name sortKey="Goldman, A" uniqKey="Goldman A">A Goldman</name></author><author><name sortKey="Campbell, G" uniqKey="Campbell G">G Campbell</name></author><author><name sortKey="Jenkins, T" uniqKey="Jenkins T">T. Jenkins</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huffman, Tn" uniqKey="Huffman T">TN. Huffman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hurles, Me" uniqKey="Hurles M">ME Hurles</name></author><author><name sortKey="Sykes, Bc" uniqKey="Sykes B">BC Sykes</name></author><author><name sortKey="Jobling, Ma" uniqKey="Jobling M">MA Jobling</name></author><author><name sortKey="Forster, P" uniqKey="Forster P">P. Forster</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kusuma, P" uniqKey="Kusuma P">P Kusuma</name></author><author><name sortKey="Brucato, N" uniqKey="Brucato N">N Brucato</name></author><author><name sortKey="Cox, Mp" uniqKey="Cox M">MP Cox</name></author><author><name sortKey="Pierron, D" uniqKey="Pierron D">D Pierron</name></author><author><name sortKey="Razafindrazaka, H" uniqKey="Razafindrazaka H">H Razafindrazaka</name></author><author><name sortKey="Adelaar, A" uniqKey="Adelaar A">A Adelaar</name></author><author><name sortKey="Sudoyo, H" uniqKey="Sudoyo H">H Sudoyo</name></author><author><name sortKey="Letellier, T" uniqKey="Letellier T">T Letellier</name></author><author><name sortKey="Ricaut, F X" uniqKey="Ricaut F">F-X. Ricaut</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kusuma, P" uniqKey="Kusuma P">P Kusuma</name></author><author><name sortKey="Cox, Mp" uniqKey="Cox M">MP Cox</name></author><author><name sortKey="Pierron, D" uniqKey="Pierron D">D Pierron</name></author><author><name sortKey="Razafindrazaka, H" uniqKey="Razafindrazaka H">H Razafindrazaka</name></author><author><name sortKey="Brucato, N" uniqKey="Brucato N">N Brucato</name></author><author><name sortKey="Tonasso, L" uniqKey="Tonasso L">L Tonasso</name></author><author><name sortKey="Suryadi, Hl" uniqKey="Suryadi H">HL Suryadi</name></author><author><name sortKey="Letellier, T" uniqKey="Letellier T">T Letellier</name></author><author><name sortKey="Sudoyo, H" uniqKey="Sudoyo H">H Sudoyo</name></author><author><name sortKey="Ricaut, F X" uniqKey="Ricaut F">F-X. Ricaut</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lawler, A" uniqKey="Lawler A">A. Lawler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lawson, Dj" uniqKey="Lawson D">DJ Lawson</name></author><author><name sortKey="Hellenthal, G" uniqKey="Hellenthal G">G Hellenthal</name></author><author><name sortKey="Myers, S" uniqKey="Myers S">S Myers</name></author><author><name sortKey="Falush, D" uniqKey="Falush D">D. Falush</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Loh, Pr" uniqKey="Loh P">PR Loh</name></author><author><name sortKey="Lipson, M" uniqKey="Lipson M">M Lipson</name></author><author><name sortKey="Patterson, N" uniqKey="Patterson N">N Patterson</name></author><author><name sortKey="Moorjani, P" uniqKey="Moorjani P">P Moorjani</name></author><author><name sortKey="Pickrell, Jk" uniqKey="Pickrell J">JK Pickrell</name></author><author><name sortKey="Reich, D" uniqKey="Reich D">D Reich</name></author><author><name sortKey="Berger, B" uniqKey="Berger B">B. Berger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Patterson, N" uniqKey="Patterson N">N Patterson</name></author><author><name sortKey="Price, Al" uniqKey="Price A">AL Price</name></author><author><name sortKey="Reich, D" uniqKey="Reich D">D. Reich</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Patterson, Nj" uniqKey="Patterson N">NJ Patterson</name></author><author><name sortKey="Moorjani, P" uniqKey="Moorjani P">P Moorjani</name></author><author><name sortKey="Luo, Y" uniqKey="Luo Y">Y Luo</name></author><author><name sortKey="Mallick, S" uniqKey="Mallick S">S Mallick</name></author><author><name sortKey="Rohland, N" uniqKey="Rohland N">N Rohland</name></author><author><name sortKey="Zhan, Y" uniqKey="Zhan Y">Y Zhan</name></author><author><name sortKey="Genschoreck, T" uniqKey="Genschoreck T">T Genschoreck</name></author><author><name sortKey="Webster, T" uniqKey="Webster T">T Webster</name></author><author><name sortKey="Reich, D" uniqKey="Reich D">D. Reich</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pickrell, Jk" uniqKey="Pickrell J">JK Pickrell</name></author><author><name sortKey="Pritchard, Jk" uniqKey="Pritchard J">JK. Pritchard</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pierron, D" uniqKey="Pierron D">D Pierron</name></author><author><name sortKey="Razafindrazaka, H" uniqKey="Razafindrazaka H">H Razafindrazaka</name></author><author><name sortKey="Pagani, L" uniqKey="Pagani L">L Pagani</name></author><author><name sortKey="Ricaut, F X" uniqKey="Ricaut F">F-X Ricaut</name></author><author><name sortKey="Antao, T" uniqKey="Antao T">T Antao</name></author><author><name sortKey="Capredon, M" uniqKey="Capredon M">M Capredon</name></author><author><name sortKey="Sambo, C" uniqKey="Sambo C">C Sambo</name></author><author><name sortKey="Radimilahy, C" uniqKey="Radimilahy C">C Radimilahy</name></author><author><name sortKey="Rakotoarisoa, J A" uniqKey="Rakotoarisoa J">J-A Rakotoarisoa</name></author><author><name sortKey="Blench, Rm" uniqKey="Blench R">RM Blench</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ras, Jj" uniqKey="Ras J">JJ. Ras</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Serva, M" uniqKey="Serva M">M Serva</name></author><author><name sortKey="Petroni, F" uniqKey="Petroni F">F Petroni</name></author><author><name sortKey="Volchenkov, D" uniqKey="Volchenkov D">D Volchenkov</name></author><author><name sortKey="Wichmann, S" uniqKey="Wichmann S">S. Wichmann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Soodyall, H" uniqKey="Soodyall H">H Soodyall</name></author><author><name sortKey="Jenkins, T" uniqKey="Jenkins T">T Jenkins</name></author><author><name sortKey="Hewitt, R" uniqKey="Hewitt R">R Hewitt</name></author><author><name sortKey="Krause, A" uniqKey="Krause A">A Krause</name></author><author><name sortKey="Stoneking, M" uniqKey="Stoneking M">M. Stoneking</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tofanelli, S" uniqKey="Tofanelli S">S Tofanelli</name></author><author><name sortKey="Bertoncini, S" uniqKey="Bertoncini S">S Bertoncini</name></author><author><name sortKey="Castri, L" uniqKey="Castri L">L Castri</name></author><author><name sortKey="Luiselli, D" uniqKey="Luiselli D">D Luiselli</name></author><author><name sortKey="Calafell, F" uniqKey="Calafell F">F Calafell</name></author><author><name sortKey="Donati, G" uniqKey="Donati G">G Donati</name></author><author><name sortKey="Paoli, G" uniqKey="Paoli G">G. Paoli</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Mol Biol Evol</journal-id><journal-id journal-id-type="iso-abbrev">Mol. Biol. Evol</journal-id><journal-id journal-id-type="publisher-id">molbev</journal-id><journal-id journal-id-type="hwp">molbiolevol</journal-id><journal-title-group><journal-title>Molecular Biology and Evolution</journal-title></journal-title-group><issn pub-type="ppub">0737-4038</issn><issn pub-type="epub">1537-1719</issn><publisher><publisher-name>Oxford University Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">27381999</article-id><article-id pub-id-type="pmc">4989113</article-id><article-id pub-id-type="doi">10.1093/molbev/msw117</article-id><article-id pub-id-type="publisher-id">msw117</article-id><article-categories><subj-group subj-group-type="heading"><subject>Discoveries</subject></subj-group></article-categories><title-group><article-title>Malagasy Genetic Ancestry Comes from an Historical Malay Trading Post in Southeast Borneo</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Brucato</surname><given-names>Nicolas</given-names></name><xref ref-type="author-notes" rid="msw117-FM2"><sup>†</sup></xref><xref ref-type="aff" rid="msw117-aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Kusuma</surname><given-names>Pradiptajati</given-names></name><xref ref-type="author-notes" rid="msw117-FM2"><sup>†</sup></xref><xref ref-type="aff" rid="msw117-aff1"><sup>1</sup></xref><xref ref-type="aff" rid="msw117-aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Cox</surname><given-names>Murray P.</given-names></name><xref ref-type="aff" rid="msw117-aff3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Pierron</surname><given-names>Denis</given-names></name><xref ref-type="aff" rid="msw117-aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Purnomo</surname><given-names>Gludhug A.</given-names></name><xref ref-type="aff" rid="msw117-aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Adelaar</surname><given-names>Alexander</given-names></name><xref ref-type="aff" rid="msw117-aff4"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>Kivisild</surname><given-names>Toomas</given-names></name><xref ref-type="aff" rid="msw117-aff5"><sup>5</sup></xref><xref ref-type="aff" rid="msw117-aff6"><sup>6</sup></xref></contrib><contrib contrib-type="author"><name><surname>Letellier</surname><given-names>Thierry</given-names></name><xref ref-type="aff" rid="msw117-aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Sudoyo</surname><given-names>Herawati</given-names></name><xref ref-type="aff" rid="msw117-aff2"><sup>2</sup></xref><xref ref-type="aff" rid="msw117-aff7"><sup>7</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ricaut</surname><given-names>François-Xavier</given-names></name><xref ref-type="corresp" rid="msw117-cor1">*</xref><xref ref-type="aff" rid="msw117-aff1"><sup>1</sup></xref></contrib><aff id="msw117-aff1"><sup>1</sup>Evolutionary Medicine Group, Laboratoire d’Anthropologie Moléculaire et Imagerie de Synthèse UMR 5288 CNRS, Université Toulouse III, Université de Toulouse, Toulouse, France</aff><aff id="msw117-aff2"><sup>2</sup>Genome Diversity and Diseases Laboratory, Eijkman Institute for Molecular Biology, Jakarta, Indonesia</aff><aff id="msw117-aff3"><sup>3</sup>Statistics and Bioinformatics Group, Institute of Fundamental Sciences, Massey University, Palmerston North, New Zealand</aff><aff id="msw117-aff4"><sup>4</sup>Asia Institute, University of Melbourne, Melbourne, Australia</aff><aff id="msw117-aff5"><sup>5</sup>Department of Biological Anthropology, University of Cambridge, Cambridge, United Kingdom</aff><aff id="msw117-aff6"><sup>6</sup>Estonian Biocentre, Tartu, Estonia</aff><aff id="msw117-aff7"><sup>7</sup>Department of Medical Biology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia</aff></contrib-group><author-notes><fn id="msw117-FM2"><p><sup>†</sup>These authors contributed equally to this work.</p></fn><corresp id="msw117-cor1">*<bold>Corresponding author:</bold> E-mail: <email>francois-xavier.ricaut@univ-tlse3.fr</email>.</corresp><fn id="msw117-FM1"><p><bold>Associate editor</bold>: Connie Mulligan</p></fn></author-notes><pub-date pub-type="ppub"><month>9</month><year>2016</year></pub-date><pub-date pub-type="epub"><day>05</day><month>7</month><year>2016</year></pub-date><pub-date pub-type="pmc-release"><day>05</day><month>7</month><year>2016</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on the
<volume>33</volume><issue>9</issue><fpage>2396</fpage><lpage>2400</lpage><permissions><copyright-statement>© The Author 2016. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.</copyright-statement><copyright-year>2016</copyright-year><license xlink:href="http://creativecommons.org/licenses/by-nc/4.0/" license-type="creative-commons"><license-p>This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc/4.0/">http://creativecommons.org/licenses/by-nc/4.0/</ext-link>), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com</license-p></license></permissions><abstract><p>Malagasy genetic diversity results from an exceptional protoglobalization process that took place over a thousand years ago across the Indian Ocean. Previous efforts to locate the Asian origin of Malagasy highlighted Borneo broadly as a potential source, but so far no firm source populations were identified. Here, we have generated genome-wide data from two Southeast Borneo populations, the Banjar and the Ngaju, together with published data from populations across the Indian Ocean region. We find strong support for an origin of the Asian ancestry of Malagasy among the Banjar. This group emerged from the long-standing presence of a Malay Empire trading post in Southeast Borneo, which favored admixture between the Malay and an autochthonous Borneo group, the Ma’anyan. Reconciling genetic, historical, and linguistic data, we show that the Banjar, in Malay-led voyages, were the most probable Asian source among the analyzed groups in the founding of the Malagasy gene pool.</p></abstract><kwd-group><kwd>Madagascar</kwd><kwd>Austronesian</kwd><kwd>Borneo</kwd><kwd>Banjar</kwd><kwd>genome-wide.</kwd></kwd-group><counts><page-count count="5"></page-count></counts></article-meta></front><body><p>The Malagasy are the descendants of a unique prehistoric admixture event between African and Asian individuals, the outcome of one of the earliest protoglobalization processes that began approximately 4,000 years before present (BP) (<xref rid="msw117-B16" ref-type="bibr">Fuller et al. 2011</xref>; <xref rid="msw117-B7" ref-type="bibr">Beaujard 2012a</xref>, <xref rid="msw117-B8" ref-type="bibr">2012b</xref>; <xref rid="msw117-B23" ref-type="bibr">Lawler 2014</xref>). Today, this island population in the western Indian Ocean shows strong biological (<xref rid="msw117-B15" ref-type="bibr">Fourquet et al. 1974</xref>; <xref rid="msw117-B29" ref-type="bibr">Pierron et al. 2014</xref>) and linguistic (<xref rid="msw117-B4" ref-type="bibr">Adelaar 2009b</xref>; <xref rid="msw117-B31" ref-type="bibr">Serva et al. 2012</xref>) connections to east coast African and Island Southeast Asian groups. Although this remarkable admixture event has long been studied (<xref rid="msw117-B15" ref-type="bibr">Fourquet et al. 1974</xref>; <xref rid="msw117-B18" ref-type="bibr">Hewitt et al. 1996</xref>; <xref rid="msw117-B32" ref-type="bibr">Soodyall et al. 1996</xref>; <xref rid="msw117-B20" ref-type="bibr">Hurles et al. 2005</xref>; <xref rid="msw117-B33" ref-type="bibr">Tofanelli et al. 2009</xref>; <xref rid="msw117-B29" ref-type="bibr">Pierron et al. 2014</xref>; <xref rid="msw117-B22" ref-type="bibr">Kusuma et al. 2015</xref>), the settlement process—specifically the geographic origin of the populations involved, dates of settlement and the nature of the population admixture event—are still routinely debated (<xref rid="msw117-B4" ref-type="bibr">Adelaar 2009b</xref>; <xref rid="msw117-B7" ref-type="bibr">Beaujard 2012a</xref>; <xref rid="msw117-B29" ref-type="bibr">Pierron et al. 2014</xref>; <xref rid="msw117-B22" ref-type="bibr">Kusuma et al. 2015</xref>; <xref rid="msw117-B5" ref-type="bibr">Adelaar forthcoming</xref>). Both linguistic and genetic studies suggest that the western and central regions of Indonesia (particularly Java, Borneo, and Sulawesi) have the closest Asian genetic connections with modern Malagasy (<xref rid="msw117-B22" ref-type="bibr">Kusuma et al. 2015</xref><xref rid="msw117-B21" ref-type="bibr">, 2016</xref>; <xref rid="msw117-B5" ref-type="bibr">Adelaar forthcoming</xref>), and the island was probably settled by a small founding population (<xref rid="msw117-B11" ref-type="bibr">Cox et al. 2012</xref>). More specifically, recent anthropological research points to the Southeast region of Borneo as a potential source location for Malagasy (<xref rid="msw117-B21" ref-type="bibr">Kusuma et al. 2016</xref>; <xref rid="msw117-B5" ref-type="bibr">Adelaar forthcoming</xref>). However, the Indonesian parental population of the Malagasy has so far not been clearly identified (<xref rid="msw117-B22" ref-type="bibr">Kusuma et al. 2015</xref><xref rid="msw117-B21" ref-type="bibr">, 2016</xref>). To better reconstruct the settlement history of Madagascar and identify the Asian source populations, we conducted widespread sampling and genome-wide analysis of human groups across the Indian Ocean region. In particular, we present here new genome-wide data for two southeast Borneo populations, the Banjar (<italic>n</italic> = 16) and the Ngaju (<italic>n</italic> = 25) (<ext-link ext-link-type="uri" xlink:href="http://mbe.oxfordjournals.org/lookup/suppl/doi:10.1093/molbev/msw117/-/DC1">supplementary fig. S1</ext-link>, <ext-link ext-link-type="uri" xlink:href="http://mbe.oxfordjournals.org/lookup/suppl/doi:10.1093/molbev/msw117/-/DC1">Supplementary Material</ext-link> online), which have previously been noted as potential parental groups to the Malagasy (<xref rid="msw117-B5" ref-type="bibr">Adelaar forthcoming</xref>). The newly generated data were analyzed in the context of previously published data for a wide range of populations from the Indian Ocean rim (<ext-link ext-link-type="uri" xlink:href="http://mbe.oxfordjournals.org/lookup/suppl/doi:10.1093/molbev/msw117/-/DC1">supplementary table S1</ext-link>, <ext-link ext-link-type="uri" xlink:href="http://mbe.oxfordjournals.org/lookup/suppl/doi:10.1093/molbev/msw117/-/DC1">Supplementary Material</ext-link> online).</p><sec><title>The Malagasy Asian Ancestry Derives from Southeast Borneo</title><p>To identify the most probable Asian parental groups of the Malagasy, we adopted a two-stage approach: first, we identified the most likely proxy populations using a data set with wide geographical coverage but relatively low density of single nucleotide polymorphism (SNP), then followed by a higher density SNP data set that gives increased statistical power. This allows us to reconstruct the admixture processes that led to the emergence of modern Malagasy. The admixture profile of our data set (2,183 individuals from 61 populations genotyped for 40,272 SNPs; <ext-link ext-link-type="uri" xlink:href="http://mbe.oxfordjournals.org/lookup/suppl/doi:10.1093/molbev/msw117/-/DC1">supplementary figs. S2 and S3</ext-link>, <ext-link ext-link-type="uri" xlink:href="http://mbe.oxfordjournals.org/lookup/suppl/doi:10.1093/molbev/msw117/-/DC1">Supplementary Material</ext-link> online), based on ADMIXTURE analyses (<xref rid="msw117-B6" ref-type="bibr">Alexander et al. 2009</xref>), shows that the Malagasy genetic diversity is best described as a mixture of 68% African genomic components and 32% Asian components, corresponding well with the results of previous studies (<xref rid="msw117-B10" ref-type="bibr">Capredon et al. 2013</xref>; <xref rid="msw117-B29" ref-type="bibr">Pierron et al. 2014</xref>). While the African ancestry component in Malagasy appears to be broadly similar to that still present today in South African Bantu, the Asian ancestry presents a more complex pattern. This complexity is the key reason why previous studies have been unable to point firmly to a unique Asian source, making any subsequent anthropological inferences debatable (<xref rid="msw117-B29" ref-type="bibr">Pierron et al. 2014</xref>). This problem arose with a study of the Ma’anyan population of Borneo, whose language has long been identified as the closest to the Malagasy language (<xref rid="msw117-B12" ref-type="bibr">Dahl 1951</xref>), but who surprisingly exhibit no clear genetic connection to Malagasy (<xref rid="msw117-B21" ref-type="bibr">Kusuma et al. 2016</xref>). Instead, the higher genetic complexity of the Asian ancestry component in Malagasy likely reflects the fact that more than a single source population was involved in its formation. Affinities to the Malagasy Asian components are found at high frequency across several Island Southeast Asian groups, but notably in Malay, a dominant group of ancient seafaring traders (first millennium CE), and admixed groups from Borneo (i.e., Banjar, Ngaju, South Kalimantan Dayak, Lebbo, Murut, Dusun, and Bidayuh; <ext-link ext-link-type="uri" xlink:href="http://mbe.oxfordjournals.org/lookup/suppl/doi:10.1093/molbev/msw117/-/DC1">supplementary fig. S2</ext-link>, <ext-link ext-link-type="uri" xlink:href="http://mbe.oxfordjournals.org/lookup/suppl/doi:10.1093/molbev/msw117/-/DC1">Supplementary Material</ext-link> online). The connection between Malagasy, and the Borneo and Malay populations, is supported by <italic>f3</italic>-statistics (z-scores<−2; <ext-link ext-link-type="uri" xlink:href="http://mbe.oxfordjournals.org/lookup/suppl/doi:10.1093/molbev/msw117/-/DC1">supplementary table S2</ext-link>, <ext-link ext-link-type="uri" xlink:href="http://mbe.oxfordjournals.org/lookup/suppl/doi:10.1093/molbev/msw117/-/DC1">Supplementary Material</ext-link> online) (<xref rid="msw117-B27" ref-type="bibr">Patterson et al. 2012</xref>) and TreeMix analyses (35% of Malay/Borneo gene flow to Malagasy; <ext-link ext-link-type="uri" xlink:href="http://mbe.oxfordjournals.org/lookup/suppl/doi:10.1093/molbev/msw117/-/DC1">supplementary fig. S4</ext-link>, <ext-link ext-link-type="uri" xlink:href="http://mbe.oxfordjournals.org/lookup/suppl/doi:10.1093/molbev/msw117/-/DC1">Supplementary Material</ext-link> online) (<xref rid="msw117-B28" ref-type="bibr">Pickrell and Pritchard 2012</xref>). However, to more specifically identify the Asian ancestry of the Malagasy genome, we performed a Local Ancestry analysis with PCAdmix (<xref rid="msw117-B9" ref-type="bibr">Brisbin et al. 2012</xref>) using two proxy parental meta-populations comprising 100 individuals with African ancestry (randomly selected from Yoruba, South African Bantu, Kenyan Luhya, and Somali groups) and Asian ancestry (randomly selected from Chinese, Philippine Igorot, Bornean Ma’anyan, and Malay groups). Masking the haplotypes inferred to derive from Africa, we performed an ancestry-specific Principal Components Analysis (PCA) (<xref rid="msw117-B26" ref-type="bibr">Patterson et al. 2006</xref>) and TreeMix analysis (<xref rid="msw117-B28" ref-type="bibr">Pickrell and Pritchard 2012</xref>). Both show that the Asian genomic components of Malagasy cluster tightly with Southeast Borneo groups (Banjar, South Kalimantan Dayak, Ngaju, and Ma’anyan) (1,664 SNPs; <xref ref-type="fig" rid="msw117-F1">fig. 1<italic>A</italic></xref> and <ext-link ext-link-type="uri" xlink:href="http://mbe.oxfordjournals.org/lookup/suppl/doi:10.1093/molbev/msw117/-/DC1">supplementary fig. S5</ext-link>, <ext-link ext-link-type="uri" xlink:href="http://mbe.oxfordjournals.org/lookup/suppl/doi:10.1093/molbev/msw117/-/DC1">Supplementary Material</ext-link> online). This connection is supported by the highest <italic>f</italic> 3-statistics and the lowest <italic>F</italic><sub>ST</sub> genetic distances also being observed between Asian ancestry of the Malagasy and these same Southeast Borneo groups (<italic>f</italic>3 > 0.12; <italic>F</italic><sub>ST </sub><<sub> </sub>0.02; <xref ref-type="fig" rid="msw117-F1">fig. 1<italic>B</italic>;</xref><ext-link ext-link-type="uri" xlink:href="http://mbe.oxfordjournals.org/lookup/suppl/doi:10.1093/molbev/msw117/-/DC1">supplementary tables S3 and S4</ext-link>, <ext-link ext-link-type="uri" xlink:href="http://mbe.oxfordjournals.org/lookup/suppl/doi:10.1093/molbev/msw117/-/DC1">Supplementary Material</ext-link> online).
<fig id="msw117-F1" orientation="portrait" position="float"><label><sc>Fig</sc>. 1</label><caption><p>Localization of the Asian ancestry of Malagasy by (<italic>A</italic>) a TreeMix dendrogram, (<italic>B</italic>) F<sub>ST</sub> distances and <italic>f</italic>3 statistics, all based on the Asian-SNP data set, and (C) a shared identity-by-descent (IBD) analysis based on haplotypes inferred from the high density of SNP data set. (<italic>A</italic>) The TreeMix dendrogram was inferred imposing no a priori assumptions of migration, displaying only the tree topology. (<italic>B</italic>) Values of the <italic>f</italic>3 (Asian-SNP Vezo, X; Yoruba) statistics are represented by dots with standard error bars. The color of each dot corresponds to the <italic>F</italic><sub>ST</sub> distances between the Asian ancestry of the Vezo and each Asian population using a gray-yellow-red color scale from the highest (0.196) to the lowest values (0.02). (<italic>C</italic>) The cumulative shared IBD (Mb) between pairs of Malagasy:Asian individuals were averaged to obtain one value of IBD sharing per Asian population. The obtained values are represented by a gray-yellow-red color scale. The numbers 1–15 correspond to the populations presented on the TreeMix dendrogram with the addition of 16 which stands for Brahmin Indian.</p></caption><graphic xlink:href="msw117f1p"></graphic></fig></p><p>To explore this connection in more detail, we turned to the high density SNP data set (551 individuals from 24 populations genotyped for 374,189 SNPs; <ext-link ext-link-type="uri" xlink:href="http://mbe.oxfordjournals.org/lookup/suppl/doi:10.1093/molbev/msw117/-/DC1">supplementary table S1</ext-link>, <ext-link ext-link-type="uri" xlink:href="http://mbe.oxfordjournals.org/lookup/suppl/doi:10.1093/molbev/msw117/-/DC1">Supplementary Material</ext-link> online). This allows more statistically powerful analyses based on haplotypes. We confirmed the earlier result that Malagasy have the highest values of cumulative shared identity-by-descent fragments with Southeast Borneo populations (<xref ref-type="fig" rid="msw117-F1">fig. 1<italic>C</italic>;</xref><ext-link ext-link-type="uri" xlink:href="http://mbe.oxfordjournals.org/lookup/suppl/doi:10.1093/molbev/msw117/-/DC1">supplementary fig. S6</ext-link>, <ext-link ext-link-type="uri" xlink:href="http://mbe.oxfordjournals.org/lookup/suppl/doi:10.1093/molbev/msw117/-/DC1">Supplementary Material</ext-link> online). To expand on this, however, we inferred the population sources of the Malagasy, their relative ratios and the dates of potential admixture events with GLOBETROTTER (<xref rid="msw117-B17" ref-type="bibr">Hellenthal et al. 2014</xref>), defining each population in our data set as a donor/surrogate group and the Malagasy as the recipient, using the haplotype “painting” data obtained with Chromopainter (<xref rid="msw117-B24" ref-type="bibr">Lawson et al. 2012</xref>). The best fit outcome for the Malagasy was obtained under a model of a single admixture event between two sources: the Banjar representing 37% of modern Malagasy and the South African Bantu population representing the other 63% (<italic>r</italic><sup>2 </sup>=<sup> </sup>0.99, <italic>P</italic> < 0.01; <xref ref-type="fig" rid="msw117-F2">fig. 2</xref> and <ext-link ext-link-type="uri" xlink:href="http://mbe.oxfordjournals.org/lookup/suppl/doi:10.1093/molbev/msw117/-/DC1">supplementary table S5</ext-link>, <ext-link ext-link-type="uri" xlink:href="http://mbe.oxfordjournals.org/lookup/suppl/doi:10.1093/molbev/msw117/-/DC1">Supplementary Material</ext-link> online). The admixture event was dated to 675 years BP (95% CI: 625–725 years BP, <ext-link ext-link-type="uri" xlink:href="http://mbe.oxfordjournals.org/lookup/suppl/doi:10.1093/molbev/msw117/-/DC1">supplementary table S5</ext-link>, <ext-link ext-link-type="uri" xlink:href="http://mbe.oxfordjournals.org/lookup/suppl/doi:10.1093/molbev/msw117/-/DC1">Supplementary Material</ext-link> online), which is similar to the dates of admixture estimated by ALDER (550–750 years BP) using Banjar population in combination with the South African Bantu (<ext-link ext-link-type="uri" xlink:href="http://mbe.oxfordjournals.org/lookup/suppl/doi:10.1093/molbev/msw117/-/DC1">supplementary table S6</ext-link>, <ext-link ext-link-type="uri" xlink:href="http://mbe.oxfordjournals.org/lookup/suppl/doi:10.1093/molbev/msw117/-/DC1">Supplementary Material</ext-link> online) (<xref rid="msw117-B25" ref-type="bibr">Loh et al. 2013</xref>). When each Malagasy ethnic group is analyzed separately, similar parental populations, admixture proportions, and dates are obtained with the noticeable older estimated dates toward the east coast of Madagascar (<ext-link ext-link-type="uri" xlink:href="http://mbe.oxfordjournals.org/lookup/suppl/doi:10.1093/molbev/msw117/-/DC1">supplementary table S5</ext-link>, <ext-link ext-link-type="uri" xlink:href="http://mbe.oxfordjournals.org/lookup/suppl/doi:10.1093/molbev/msw117/-/DC1">Supplementary Material</ext-link> online).
<fig id="msw117-F2" orientation="portrait" position="float"><label><sc>Fig</sc>. 2</label><caption><p>Scenario for the Asian genetic ancestry in Malagasy based on the best fit models inferred by GLOBETROTTER. The brown circle represents the Malagasy (bottom left), while the green circle represents the Banjar (right). Red semicircles show the African ancestry (South African Bantu), whereas the other semicircles represent Asian ancestry from Malay (blue), Banjar (green), and Ma’anyan (yellow). Black dots highlight other populations included in the high density genomic data set. The arrows show migration events, with indicative routes, inferred in our analyses with dates of admixture in italic estimated by GLOBETROTTER. Dates in bold correspond to dates of migration estimated from archaeological and historical data (<xref rid="msw117-B7" ref-type="bibr">Beaujard 2012a</xref>).</p></caption><graphic xlink:href="msw117f2p"></graphic></fig></p><p>Crucially, these dates of genetic admixture, in agreement with a previous study (<xref rid="msw117-B29" ref-type="bibr">Pierron et al. 2014</xref>), reflect the midpoint or end of noticeable admixture between groups of Asian and African ancestry in Madagascar, rather than the start of this contact. Therefore, they could correspond to the end of the period of the main Austronesian presence in Madagascar that started around the first millennium CE (<xref rid="msw117-B12" ref-type="bibr">Dahl 1951</xref>, <xref rid="msw117-B13" ref-type="bibr">1991</xref>; <xref rid="msw117-B14" ref-type="bibr">Dewar and Wright 1993</xref>; <xref rid="msw117-B3" ref-type="bibr">Adelaar 1995</xref>; <xref rid="msw117-B11" ref-type="bibr">Cox et al. 2012</xref>; <xref rid="msw117-B5" ref-type="bibr">Adelaar forthcoming</xref>). On the other hand, around 1100–700 years BP, climatic changes in the South of Africa forced Bantu populations to move to more hospitable places (<xref rid="msw117-B19" ref-type="bibr">Huffman 2000</xref>). This South Bantu migration has previously been suggested as an explanation for the higher density of populations observed in the South of Madagascar (<xref rid="msw117-B7" ref-type="bibr">Beaujard 2012a</xref>). As all of our sampled groups live in the South of Madagascar, and considering that the estimated dates of admixture are more recent on the west coast (<ext-link ext-link-type="uri" xlink:href="http://mbe.oxfordjournals.org/lookup/suppl/doi:10.1093/molbev/msw117/-/DC1">supplementary tables S5 and S6</ext-link>, <ext-link ext-link-type="uri" xlink:href="http://mbe.oxfordjournals.org/lookup/suppl/doi:10.1093/molbev/msw117/-/DC1">Supplementary Material</ext-link> online), it is tempting to interpret our admixture date as marking the last significant Bantu migration to Madagascar, perhaps initiated by climatic changes in Africa.</p></sec><sec><title>The Proto-Malagasy People Were a Malay-Ma’anyan Admixed Group</title><p>These analyses clearly identify an Austronesian-speaking population, the Banjar in the southeast region of Borneo, as the closest Asian sources for modern Malagasy. Linguistic reconstruction of the Proto-Malagasy language indicated that it appears to be derived mainly from the Southeast Barito language spoken today by the Ma’anyan (<xref rid="msw117-B12" ref-type="bibr">Dahl 1951</xref>), a Southeast Borneo group. However, we have previously shown (<xref rid="msw117-B21" ref-type="bibr">Kusuma et al. 2016</xref>), and reconfirm here, that in genetic analyses, the Ma’anyan are only distantly related to the Malagasy in terms of genetics. In contrast, the Banjar currently speak a Malay language. Interestingly, the linguistic studies indicated a noticeable proportion of Malay words in present-day Malagasy languages (<xref rid="msw117-B2" ref-type="bibr">Adelaar 1989</xref>, <xref rid="msw117-B4" ref-type="bibr">2009b</xref>). We estimated the best fit scenario for the admixture process by modeling the current Banjar diversity with GLOBETROTTER (<xref rid="msw117-B17" ref-type="bibr">Hellenthal et al. 2014</xref>). The genetic diversity of the Banjar best fits a model of a unique admixture event (<italic>r</italic><sup>2 </sup>=<sup> </sup>0.62; <italic>P</italic> < 0.01) between two major ancestries that can be traced back to Malay (77%) and Ma’anyan (23%) (<xref ref-type="fig" rid="msw117-F2">fig. 2</xref> and <ext-link ext-link-type="uri" xlink:href="http://mbe.oxfordjournals.org/lookup/suppl/doi:10.1093/molbev/msw117/-/DC1">supplementary table S5</ext-link>, <ext-link ext-link-type="uri" xlink:href="http://mbe.oxfordjournals.org/lookup/suppl/doi:10.1093/molbev/msw117/-/DC1">Supplementary Material</ext-link> online). We estimate the date of the last noticeable admixture approximately 425 years BP (95% CI: 275–500 years BP). Since the Banjar originated from a Ma’anyan-Malay admixture, at a time preceding the supposed date of migration to Madagascar (i.e., 1000 years BP), the ancestors of the Banjar were presumably speaking a language close to that reconstructed for Proto-Malagasy (<xref rid="msw117-B5" ref-type="bibr">Adelaar forthcoming</xref>). Although we cannot fully exclude that the Malay-Ma’anyan admixture occurred in Malagasy, prior to the Bantu gene flow, the observed haplotypic structure is so similar to the ones observed in the Banjar that it is more parsimonious to interpret this admixture to have happened first in Borneo. This analysis reconciles both the linguistic and genetic data, strengthening our scenario placing the Banjar as the main Asian parental populations of the Malagasy. Their current genetic diversity appears to be the reflection of the historical relationship between Madagascar, Southeast Borneo, and the Malay. The maritime routes linking Madagascar to Borneo were particularly exploited during the rapid expansion of trading networks led by the Hindu Malay Kingdoms, such as Srivijaya (6th–13th centuries) (<xref rid="msw117-B30" ref-type="bibr">Ras 1968</xref>; <xref rid="msw117-B7" ref-type="bibr">Beaujard 2012a</xref>). Established on the islands of Sumatra and Java, the Malay traded with far-distant regions, notably across East Asia and reaching as far as East Africa (<xref rid="msw117-B7" ref-type="bibr">Beaujard 2012a</xref>). Their influence increased across all the Southeast Asian islands, notably in Borneo where they established several trading posts, such as one in the city of Banjarmasin in Southeast Borneo (<xref rid="msw117-B30" ref-type="bibr">Ras 1968</xref>; <xref rid="msw117-B7" ref-type="bibr">Beaujard 2012a</xref>). As related in the only Banjarese historical records available, the <italic>Hikayat Banjar</italic> (“Tale of Banjar”) (<xref rid="msw117-B30" ref-type="bibr">Ras 1968</xref>), the main city of the Banjar population was a major trading post in the former Malay Empires. This probably favored interactions with inland groups in Borneo, such as the Ma’anyan, but also with other populations such as the Bajo sea nomads (<ext-link ext-link-type="uri" xlink:href="http://mbe.oxfordjournals.org/lookup/suppl/doi:10.1093/molbev/msw117/-/DC1">supplementary fig. S6</ext-link> and <ext-link ext-link-type="uri" xlink:href="http://mbe.oxfordjournals.org/lookup/suppl/doi:10.1093/molbev/msw117/-/DC1">table S5</ext-link>, <ext-link ext-link-type="uri" xlink:href="http://mbe.oxfordjournals.org/lookup/suppl/doi:10.1093/molbev/msw117/-/DC1">Supplementary Material</ext-link> online) (<xref rid="msw117-B1" ref-type="bibr">Adelaar 2009a</xref>; <xref rid="msw117-B7" ref-type="bibr">Beaujard 2012a</xref>; <xref rid="msw117-B22" ref-type="bibr">Kusuma et al. 2015</xref>). The Malay domination of trading networks collapsed during the 15th–16th centuries, with the emergence of several sultanates and the arrival of Europeans, which could correspond to the end of noticeable Malay gene flow into the Banjar population, as indicated by our estimated date of admixture between Malay and Ma’anyan around 425 years BP.</p><p>Our study provides strong support for a new scenario for the Austronesian settlement of Madagascar, reconciling cultural, linguistic, and genetic data, in which the Banjar population played key roles in establishing the Asian founder population of the Malagasy. The Malay trading networks during the first millennium CE triggered one of the earliest protoglobalization processes, bringing Southeast Asian populations to East Africa (<xref rid="msw117-B7" ref-type="bibr">Beaujard 2012a</xref>). The Banjar, currently living in Southeast Borneo, show the highest affinity to the main genetic ancestry component in Malagasy and can therefore be suggested to be likely to have been the ethnic group that accompanied the Malay in their maritime voyages to Madagascar. This population with composite ethnic ancestry emerged from the long-standing presence of Malay in Borneo, creating an admixed community with local Austronesian-speaking groups, such as the Ma’anyan. Before the probable date of migration (around 1000 years BP), the ancestors of the current Banjar would have contained both Malay and Ma’anyan genetic diversity, and probably linguistic inheritances from both (<xref rid="msw117-B5" ref-type="bibr">Adelaar forthcoming</xref>). Although the exact maritime route(s) of migration from Borneo to Madagascar are still an open question, our study identifies the flow of Malay-Ma’anyan genomic ancestries as carried by Banjar ancestors as the source to Malagasy.</p></sec><sec sec-type="materials|methods"><title>Materials and Methods</title><p>All experimental and analytical procedures are described in the <ext-link ext-link-type="uri" xlink:href="http://mbe.oxfordjournals.org/lookup/suppl/doi:10.1093/molbev/msw117/-/DC1">supplementary method</ext-link> file, <ext-link ext-link-type="uri" xlink:href="http://mbe.oxfordjournals.org/lookup/suppl/doi:10.1093/molbev/msw117/-/DC1">Supplementary Material</ext-link> online. This study was approved by the Research Ethics Commission of the Eijkman Institute for Molecular Biology (Jakarta, Indonesia).</p></sec><sec sec-type="supplementary-material"><title>Supplementary Material</title><p><ext-link ext-link-type="uri" xlink:href="http://mbe.oxfordjournals.org/lookup/suppl/doi:10.1093/molbev/msw117/-/DC1">Supplementary material</ext-link> is available at <italic>Molecular Biology and Evolution</italic> online (<ext-link ext-link-type="uri" xlink:href="http://www.mbe.oxfordjournals.org/">http://www.mbe.oxfordjournals.org/</ext-link>).</p><supplementary-material id="PMC_1" content-type="local-data"><caption><title>Supplementary Data</title></caption><media mimetype="text" mime-subtype="html" xlink:href="supp_33_9_2396__index.html"></media><media xlink:role="associated-file" mimetype="application" mime-subtype="pdf" xlink:href="supp_msw117_Banjar_Paper_MBE_v01062016_Sup_Files_Revised_COMPLETE.pdf"></media></supplementary-material></sec></body><back><ack><title>Acknowledgments</title><p>The authors thank the Eijkman Institute for Molecular Biology (Jakarta, Indonesia), especially Alida Harahap and Deni Feriandika, and the Department of Health, Banjarmasin city in the province of South Kalimantan, for accommodating the sampling program. The authors wish to acknowledge support from the GenoToul bioinformatics facility of the Genopole Toulouse Midi Pyrénées, France. They also thank Harilanto Razafindrazaka for her useful comments on the manuscript. This research was supported by <funding-source>French ANR</funding-source> grant number <award-id>ANR-14-CE31-0013-01</award-id> (grant <award-id>OceoAdapto</award-id> to F.-X.R.), the French Ministry of Foreign and European Affairs (French Archaeological Mission in Borneo (MAFBO) to F.-X.R.), and the French Embassy in Indonesia through its Cultural and Cooperation Services (Institut Français en Indonésie). Genetic data have been deposited at the European Genome-phenome Archive (EGA, <ext-link ext-link-type="uri" xlink:href="https://ega-archive.org">https://ega-archive.org</ext-link>), jointly managed by the EBI and CRG, under accession number <award-id>EGAS00001001841</award-id>.</p></ack><ref-list><title>References</title><ref id="msw117-B1"><mixed-citation publication-type="book"><person-group person-group-type="author"><name><surname>Adelaar</surname><given-names>KA.</given-names></name></person-group><year>2009a</year><chapter-title>Towards an Integrated Theory about the lndonesian Migrations to Madagascar</chapter-title> In: <source>Peregrine PN, Peiros I, M. F, editors. Ancient human migrations: a multidisciplinary approach</source>. <publisher-name>Salt Lake City</publisher-name>: University of Utah Press. p. 149–172.</mixed-citation></ref><ref id="msw117-B2"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Adelaar</surname><given-names>KA.</given-names></name></person-group><year>1989</year><article-title>Malay influence on Malagasy: linguistic and culture-historical implications</article-title>. <source>Ocean Linguist.</source><volume>28</volume>:<fpage>1</fpage>–<lpage>46</lpage>.</mixed-citation></ref><ref id="msw117-B3"><mixed-citation publication-type="book"><person-group person-group-type="author"><name><surname>Adelaar</surname><given-names>KA.</given-names></name></person-group><year>1995</year><chapter-title>Borneo as a cross-roads for comparative Austronesian linguistics</chapter-title> In: <person-group person-group-type="editor"><name><surname>Fox</surname><given-names>JJ</given-names></name></person-group>, Tryon D, Bellwood P, editor. <source>The Austronesians: comparative and historical perspectives. Canberra (Australia): The Australian National University</source>. p. <fpage>75</fpage>–<lpage>95</lpage>.</mixed-citation></ref><ref id="msw117-B4"><mixed-citation publication-type="book"><person-group person-group-type="author"><name><surname>Adelaar</surname><given-names>KA.</given-names></name></person-group><year>2009b</year><chapter-title>Loanwords in Malagasy</chapter-title> In: <person-group person-group-type="editor"><name><surname>Haspelmath</surname><given-names>M</given-names></name><name><surname>Tadmor</surname><given-names>U</given-names></name></person-group>, editors. <source>Loanwords in the world’s languages: a comparative handbook</source>. <publisher-loc>Berlin, Germany</publisher-loc>: <publisher-name>De Gruyter Mouton</publisher-name> p. <fpage>717</fpage>–<lpage>746</lpage>.</mixed-citation></ref><ref id="msw117-B5"><mixed-citation publication-type="book"><person-group person-group-type="author"><name><surname>Adelaar</surname><given-names>KA.</given-names></name></person-group> Forthcoming. <chapter-title>Who were the first Malagasy, and what did they speak</chapter-title>? In: <person-group person-group-type="editor"><name><surname>Acri</surname><given-names>A</given-names></name><name><surname>Landmann</surname><given-names>A</given-names></name></person-group>, editors. <source>Cultural Transfer in Early Monsoon Asia</source>. <publisher-loc>Singapore</publisher-loc>: <publisher-name>Institute of Southeast Asian Studies</publisher-name>.</mixed-citation></ref><ref id="msw117-B6"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Alexander</surname><given-names>DH</given-names></name><name><surname>Novembre</surname><given-names>J</given-names></name><name><surname>Lange</surname><given-names>K.</given-names></name></person-group><year>2009</year><article-title>Fast model-based estimation of ancestry in unrelated individuals</article-title>. <source>Genome Res.</source><volume>19</volume>:<fpage>1655</fpage>–<lpage>1664</lpage>.<pub-id pub-id-type="pmid">19648217</pub-id></mixed-citation></ref><ref id="msw117-B7"><mixed-citation publication-type="other"><person-group person-group-type="author"><name><surname>Beaujard</surname><given-names>P.</given-names></name></person-group><year>2012a</year>. Les mondes de l’ocean indien. Vol. 2: L’océan Indien, au cœur des globalisations de l'Ancien Monde (7e-15e siècles). Paris, France: Armand Collin.</mixed-citation></ref><ref id="msw117-B8"><mixed-citation publication-type="other"><person-group person-group-type="author"><name><surname>Beaujard</surname><given-names>P.</given-names></name></person-group><year>2012b</year>. Les mondes de l’océan Indien. Vol. 1: De la formation de l’État au premier système-monde afro-eurasien (4e millénaire av. J.-C.-6e siècle apr. J.-C.). Paris, France: Armand Collin.</mixed-citation></ref><ref id="msw117-B9"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Brisbin</surname><given-names>A</given-names></name><name><surname>Bryc</surname><given-names>K</given-names></name><name><surname>Byrnes</surname><given-names>J</given-names></name><name><surname>Zakharia</surname><given-names>F</given-names></name><name><surname>Omberg</surname><given-names>L</given-names></name><name><surname>Degenhardt</surname><given-names>J</given-names></name><name><surname>Reynolds</surname><given-names>A</given-names></name><name><surname>Ostrer</surname><given-names>H</given-names></name><name><surname>Mezey</surname><given-names>JG</given-names></name><name><surname>Bustamante</surname><given-names>CD.</given-names></name></person-group><year>2012</year><article-title>PCAdmix: principal components-based assignment of ancestry along each chromosome in individuals with admixed ancestry from two or more populations</article-title>. <source>Hum Biol.</source><volume>84</volume>:<fpage>343</fpage>–<lpage>364</lpage>.<pub-id pub-id-type="pmid">23249312</pub-id></mixed-citation></ref><ref id="msw117-B10"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Capredon</surname><given-names>M</given-names></name><name><surname>Brucato</surname><given-names>N</given-names></name><name><surname>Tonasso</surname><given-names>L</given-names></name><name><surname>Choesmel-Cadamuro</surname><given-names>V</given-names></name><name><surname>Ricaut</surname><given-names>F-X</given-names></name><name><surname>Razafindrazaka</surname><given-names>H</given-names></name><name><surname>Rakotondrabe</surname><given-names>AB</given-names></name><name><surname>Ratolojanahary</surname><given-names>MA</given-names></name><name><surname>Randriamarolaza</surname><given-names>L-P</given-names></name><name><surname>Champion</surname><given-names>B</given-names></name></person-group><etal></etal><year>2013</year><article-title>Tracing Arab-Islamic inheritance in Madagascar: study of the Y-chromosome and mitochondrial DNA in the Antemoro</article-title>. <source>PLoS One</source><volume>8</volume>:<fpage>e80932.</fpage><pub-id pub-id-type="pmid">24278350</pub-id></mixed-citation></ref><ref id="msw117-B11"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Cox</surname><given-names>MP</given-names></name><name><surname>Nelson</surname><given-names>MG</given-names></name><name><surname>Tumonggor</surname><given-names>MK</given-names></name><name><surname>Ricaut</surname><given-names>F-X</given-names></name><name><surname>Sudoyo</surname><given-names>H.</given-names></name></person-group><year>2012</year><article-title>A small cohort of Island Southeast Asian women founded Madagascar. <italic>Proc</italic></article-title><source>R Soc B Biol Sci</source>. <volume>279</volume>:<fpage>2761</fpage>–<lpage>2768</lpage>.</mixed-citation></ref><ref id="msw117-B12"><mixed-citation publication-type="book"><person-group person-group-type="author"><name><surname>Dahl</surname><given-names>OC.</given-names></name></person-group><year>1951</year><source>Malgache et maanjan: une comparaison linguistique</source>. <publisher-loc>Oslo, Norway</publisher-loc>: <publisher-name>Edege-Intituttet</publisher-name>.</mixed-citation></ref><ref id="msw117-B13"><mixed-citation publication-type="book"><person-group person-group-type="author"><name><surname>Dahl</surname><given-names>OC.</given-names></name></person-group><year>1991</year><source>Migration from Kalimantan to Madagascar</source>. <publisher-loc>Oslo, Norway</publisher-loc>: <publisher-name>Norwegian University Press: Institute for Comparative Research in Human Culture</publisher-name>.</mixed-citation></ref><ref id="msw117-B14"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Dewar</surname><given-names>RE</given-names></name><name><surname>Wright</surname><given-names>HT.</given-names></name></person-group><year>1993</year><article-title>The culture history of Madagascar</article-title>. <source>J World Prehist</source>. <volume>7</volume>:<fpage>417</fpage>–<lpage>466</lpage>.</mixed-citation></ref><ref id="msw117-B15"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Fourquet</surname><given-names>R</given-names></name><name><surname>Sarthou</surname><given-names>J</given-names></name><name><surname>Roux</surname><given-names>J</given-names></name><name><surname>Aori</surname><given-names>K.</given-names></name></person-group><year>1974</year><article-title>Hemoglobine S et origines du peuplement de Madagascar: nouvelle hypothese sur son introduction en Afrique [Hemoglobin S and origins for the settlement of Madagascar: new hypothesis on its introduction to Africa]</article-title>. <source>Arch Inst Pasteur Madagascar</source>. <volume>43</volume>:<fpage>185</fpage>–<lpage>220</lpage>.</mixed-citation></ref><ref id="msw117-B16"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Fuller</surname><given-names>DQ</given-names></name><name><surname>Boivin</surname><given-names>N</given-names></name><name><surname>Hoogervorst</surname><given-names>T</given-names></name><name><surname>Allaby</surname><given-names>R.</given-names></name></person-group><year>2011</year><article-title>Across the Indian Ocean: the prehistoric movement of plants and animals</article-title>. <source>Antiquity</source><volume>85</volume>:<fpage>544</fpage>–<lpage>558</lpage>.</mixed-citation></ref><ref id="msw117-B17"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Hellenthal</surname><given-names>G</given-names></name><name><surname>Busby</surname><given-names>GB</given-names></name><name><surname>Band</surname><given-names>G</given-names></name><name><surname>Wilson</surname><given-names>JF</given-names></name><name><surname>Capelli</surname><given-names>C</given-names></name><name><surname>Falush</surname><given-names>D</given-names></name><name><surname>Myers</surname><given-names>S.</given-names></name></person-group><year>2014</year><article-title>A genetic atlas of human admixture history</article-title>. <source>Science</source><volume>343</volume>:<fpage>747</fpage>–<lpage>751</lpage>.<pub-id pub-id-type="pmid">24531965</pub-id></mixed-citation></ref><ref id="msw117-B18"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Hewitt</surname><given-names>R</given-names></name><name><surname>Krause</surname><given-names>A</given-names></name><name><surname>Goldman</surname><given-names>A</given-names></name><name><surname>Campbell</surname><given-names>G</given-names></name><name><surname>Jenkins</surname><given-names>T.</given-names></name></person-group><year>1996</year><article-title>Beta-globin haplotype analysis suggests that a major source of Malagasy ancestry is derived from Bantu-speaking Negroids</article-title>. <source>Am J Hum Genet</source>. <volume>58</volume>:<fpage>1303</fpage>–<lpage>1308</lpage>.<pub-id pub-id-type="pmid">8651308</pub-id></mixed-citation></ref><ref id="msw117-B19"><mixed-citation publication-type="book"><person-group person-group-type="author"><name><surname>Huffman</surname><given-names>TN.</given-names></name></person-group><year>2000</year><chapter-title>Mapungubwe and the origins of the Zimbabwe culture</chapter-title> In: <person-group person-group-type="editor"><name><surname>Leslie</surname><given-names>M</given-names></name><name><surname>Maggs</surname><given-names>T</given-names></name></person-group>, editors. <source>African naissance: The Limpopo valley 1000 years ago</source>. <publisher-loc>Cape Town, South Africa</publisher-loc>: <publisher-name>South African Archaeological Society</publisher-name> p. <fpage>14</fpage>–<lpage>29</lpage>.</mixed-citation></ref><ref id="msw117-B20"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Hurles</surname><given-names>ME</given-names></name><name><surname>Sykes</surname><given-names>BC</given-names></name><name><surname>Jobling</surname><given-names>MA</given-names></name><name><surname>Forster</surname><given-names>P.</given-names></name></person-group><year>2005</year><article-title>The dual origin of the Malagasy in Island Southeast Asia and East Africa: evidence from maternal and paternal lineages</article-title>. <source>Am J Hum Genet</source>. <volume>76</volume>:<fpage>894</fpage>–<lpage>901</lpage>.<pub-id pub-id-type="pmid">15793703</pub-id></mixed-citation></ref><ref id="msw117-B21"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kusuma</surname><given-names>P</given-names></name><name><surname>Brucato</surname><given-names>N</given-names></name><name><surname>Cox</surname><given-names>MP</given-names></name><name><surname>Pierron</surname><given-names>D</given-names></name><name><surname>Razafindrazaka</surname><given-names>H</given-names></name><name><surname>Adelaar</surname><given-names>A</given-names></name><name><surname>Sudoyo</surname><given-names>H</given-names></name><name><surname>Letellier</surname><given-names>T</given-names></name><name><surname>Ricaut</surname><given-names>F-X.</given-names></name></person-group><year>2016</year><article-title>Contrasting linguistic and genetic influences during the Austronesian Settlement of Madagascar</article-title>. <source>Sci Rep.</source><volume>6</volume>:<fpage>26066.</fpage><pub-id pub-id-type="pmid">27188237</pub-id></mixed-citation></ref><ref id="msw117-B22"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kusuma</surname><given-names>P</given-names></name><name><surname>Cox</surname><given-names>MP</given-names></name><name><surname>Pierron</surname><given-names>D</given-names></name><name><surname>Razafindrazaka</surname><given-names>H</given-names></name><name><surname>Brucato</surname><given-names>N</given-names></name><name><surname>Tonasso</surname><given-names>L</given-names></name><name><surname>Suryadi</surname><given-names>HL</given-names></name><name><surname>Letellier</surname><given-names>T</given-names></name><name><surname>Sudoyo</surname><given-names>H</given-names></name><name><surname>Ricaut</surname><given-names>F-X.</given-names></name></person-group><year>2015</year><article-title>Mitochondrial DNA and the Y chromosome suggest the settlement of Madagascar by Indonesian sea nomad populations</article-title>. <source>BMC Genomics</source><volume>16</volume>:<fpage>191.</fpage><pub-id pub-id-type="pmid">25880430</pub-id></mixed-citation></ref><ref id="msw117-B23"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lawler</surname><given-names>A.</given-names></name></person-group><year>2014</year><article-title>Sailing Sinbad's seas</article-title>. <source>Science</source><volume>344</volume>:<fpage>1440</fpage>–<lpage>1445</lpage>.<pub-id pub-id-type="pmid">24970060</pub-id></mixed-citation></ref><ref id="msw117-B24"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lawson</surname><given-names>DJ</given-names></name><name><surname>Hellenthal</surname><given-names>G</given-names></name><name><surname>Myers</surname><given-names>S</given-names></name><name><surname>Falush</surname><given-names>D.</given-names></name></person-group><year>2012</year><article-title>Inference of population structure using dense haplotype data</article-title>. <source>PLoS Genet</source>. <volume>8</volume>:<fpage>e1002453.</fpage><pub-id pub-id-type="pmid">22291602</pub-id></mixed-citation></ref><ref id="msw117-B25"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Loh</surname><given-names>PR</given-names></name><name><surname>Lipson</surname><given-names>M</given-names></name><name><surname>Patterson</surname><given-names>N</given-names></name><name><surname>Moorjani</surname><given-names>P</given-names></name><name><surname>Pickrell</surname><given-names>JK</given-names></name><name><surname>Reich</surname><given-names>D</given-names></name><name><surname>Berger</surname><given-names>B.</given-names></name></person-group><year>2013</year><article-title>Inferring admixture histories of human populations using linkage disequilibrium</article-title>. <source>Genetics</source><volume>193</volume>:<fpage>1233</fpage>–<lpage>1254</lpage>.<pub-id pub-id-type="pmid">23410830</pub-id></mixed-citation></ref><ref id="msw117-B26"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Patterson</surname><given-names>N</given-names></name><name><surname>Price</surname><given-names>AL</given-names></name><name><surname>Reich</surname><given-names>D.</given-names></name></person-group><year>2006</year><article-title>Population structure and eigenanalysis</article-title>. <source>PLoS Genet</source>. <volume>2</volume>:<fpage>e190.</fpage><pub-id pub-id-type="pmid">17194218</pub-id></mixed-citation></ref><ref id="msw117-B27"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Patterson</surname><given-names>NJ</given-names></name><name><surname>Moorjani</surname><given-names>P</given-names></name><name><surname>Luo</surname><given-names>Y</given-names></name><name><surname>Mallick</surname><given-names>S</given-names></name><name><surname>Rohland</surname><given-names>N</given-names></name><name><surname>Zhan</surname><given-names>Y</given-names></name><name><surname>Genschoreck</surname><given-names>T</given-names></name><name><surname>Webster</surname><given-names>T</given-names></name><name><surname>Reich</surname><given-names>D.</given-names></name></person-group><year>2012</year><article-title>Ancient admixture in human history</article-title>. <source>Genetics</source><volume>192</volume>:<fpage>1065</fpage>–<lpage>1093</lpage>.<pub-id pub-id-type="pmid">22960212</pub-id></mixed-citation></ref><ref id="msw117-B28"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Pickrell</surname><given-names>JK</given-names></name><name><surname>Pritchard</surname><given-names>JK.</given-names></name></person-group><year>2012</year><article-title>Inference of population splits and mixtures from genome-wide allele frequency data</article-title>. <source>PLoS Genet</source>. <volume>8</volume>:<fpage>e1002967.</fpage><pub-id pub-id-type="pmid">23166502</pub-id></mixed-citation></ref><ref id="msw117-B29"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Pierron</surname><given-names>D</given-names></name><name><surname>Razafindrazaka</surname><given-names>H</given-names></name><name><surname>Pagani</surname><given-names>L</given-names></name><name><surname>Ricaut</surname><given-names>F-X</given-names></name><name><surname>Antao</surname><given-names>T</given-names></name><name><surname>Capredon</surname><given-names>M</given-names></name><name><surname>Sambo</surname><given-names>C</given-names></name><name><surname>Radimilahy</surname><given-names>C</given-names></name><name><surname>Rakotoarisoa</surname><given-names>J-A</given-names></name><name><surname>Blench</surname><given-names>RM</given-names></name></person-group>, <etal></etal><year>2014</year><article-title>Genome-wide evidence of Austronesian–Bantu admixture and cultural reversion in a hunter-gatherer group of Madagascar</article-title>. <source>Proc Natl Acad Sci U S A</source>.<volume>111</volume>:<fpage>936</fpage>–<lpage>941</lpage>.<pub-id pub-id-type="pmid">24395773</pub-id></mixed-citation></ref><ref id="msw117-B30"><mixed-citation publication-type="book"><person-group person-group-type="author"><name><surname>Ras</surname><given-names>JJ.</given-names></name></person-group><year>1968</year><source>Hikajat Banjar: a study in Malay historiography</source>. <publisher-loc>The Hague</publisher-loc>: <publisher-name>Martinus Nijhoff</publisher-name>.</mixed-citation></ref><ref id="msw117-B31"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Serva</surname><given-names>M</given-names></name><name><surname>Petroni</surname><given-names>F</given-names></name><name><surname>Volchenkov</surname><given-names>D</given-names></name><name><surname>Wichmann</surname><given-names>S.</given-names></name></person-group><year>2012</year><article-title>Malagasy dialects and the peopling of Madagascar</article-title>. <source>J R Soc Interface</source>. <volume>9</volume>:<fpage>54</fpage>–<lpage>67</lpage>.<pub-id pub-id-type="pmid">21632612</pub-id></mixed-citation></ref><ref id="msw117-B32"><mixed-citation publication-type="book"><person-group person-group-type="author"><name><surname>Soodyall</surname><given-names>H</given-names></name><name><surname>Jenkins</surname><given-names>T</given-names></name><name><surname>Hewitt</surname><given-names>R</given-names></name><name><surname>Krause</surname><given-names>A</given-names></name><name><surname>Stoneking</surname><given-names>M.</given-names></name></person-group><year>1996</year><chapter-title>The peopling of Madagascar</chapter-title> In: <person-group person-group-type="editor"><name><surname>Boyce</surname><given-names>A</given-names></name><name><surname>Mascie-Taylor</surname><given-names>C</given-names></name></person-group>, editors. <source>Molecular biology and human diversity</source>. <publisher-loc>Cambridge, UK</publisher-loc>: <publisher-name>Cambridge University Press</publisher-name> p. <fpage>156</fpage>–<lpage>170</lpage>.</mixed-citation></ref><ref id="msw117-B33"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Tofanelli</surname><given-names>S</given-names></name><name><surname>Bertoncini</surname><given-names>S</given-names></name><name><surname>Castri</surname><given-names>L</given-names></name><name><surname>Luiselli</surname><given-names>D</given-names></name><name><surname>Calafell</surname><given-names>F</given-names></name><name><surname>Donati</surname><given-names>G</given-names></name><name><surname>Paoli</surname><given-names>G.</given-names></name></person-group><year>2009</year><article-title>On the origins and admixture of Malagasy: new evidence from high-resolution analyses of paternal and maternal lineages</article-title>. <source>Mol Biol Evol</source>. <volume>26</volume>:<fpage>2109</fpage>–<lpage>2124</lpage>.<pub-id pub-id-type="pmid">19535740</pub-id></mixed-citation></ref></ref-list></back></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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