Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47
Identifieur interne : 002244 ( Pmc/Checkpoint ); précédent : 002243; suivant : 002245Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47
Auteurs : Carl A. Anderson [Royaume-Uni] ; Gabrielle Boucher [Canada] ; Charlie W. Lees [Royaume-Uni] ; Andre Franke [Allemagne] ; Mauro D Mato [Suède] ; Kent D. Taylor [États-Unis] ; James C. Lee [Royaume-Uni] ; Philippe Goyette [Canada] ; Marcin Imielinski [États-Unis] ; Anna Latiano [Italie] ; Caroline Lagacé [Canada] ; Regan Scott [États-Unis] ; Leila Amininejad [Belgique] ; Suzannah Bumpstead [Royaume-Uni] ; Leonard Baidoo [États-Unis] ; Robert N. Baldassano [États-Unis] ; Murray Barclay [Nouvelle-Zélande] ; Theodore M. Bayless [États-Unis] ; Stephan Brand [Allemagne] ; Carsten Büning [Allemagne] ; Jean-Frédéric Colombel [France] ; Lee A. Denson [États-Unis] ; Martine De Vos [Belgique] ; Marla Dubinsky [États-Unis] ; Cathryn Edwards [Royaume-Uni] ; David Ellinghaus [Allemagne] ; Rudolf S. N. Fehrmann [Pays-Bas] ; James A. B. Floyd [Royaume-Uni] ; Tim Florin [Australie] ; Denis Franchimont [Belgique] ; Lude Franke [Pays-Bas] ; Michel Georges [Belgique] ; Jürgen Glas [Allemagne] ; Nicole L. Glazer [États-Unis] ; Stephen L. Guthery [États-Unis] ; Talin Haritunians [États-Unis] ; Nicholas K. Hayward [Australie] ; Jean-Pierre Hugot [France] ; Gilles Jobin [Canada] ; Debby Laukens [Belgique] ; Ian Lawrance [Australie] ; Marc Lémann [France] ; Arie Levine [Israël] ; Cecile Libioulle [Belgique] ; Edouard Louis [Belgique] ; Dermot P. Mcgovern [États-Unis] ; Monica Milla [Italie] ; Grant W. Montgomery [Australie] ; Katherine I. Morley [Royaume-Uni] ; Craig Mowat [Royaume-Uni] ; Aylwin Ng [États-Unis] ; William Newman [Royaume-Uni] ; Roel A. Ophoff [Pays-Bas] ; Laura Papi [Italie] ; Orazio Palmieri [Italie] ; Laurent Peyrin-Biroulet [France] ; Julián Panés [Espagne] ; Anne Phillips [Royaume-Uni] ; Natalie J. Prescott [Royaume-Uni] ; Deborah D. Proctor [États-Unis] ; Rebecca Roberts [Nouvelle-Zélande] ; Richard Russell [Royaume-Uni] ; Paul Rutgeerts [Belgique] ; Jeremy Sanderson [Royaume-Uni] ; Miquel Sans [Espagne] ; Philip Schumm [États-Unis] ; Frank Seibold [Suisse] ; Yashoda Sharma [États-Unis] ; Lisa Simms [Australie] ; Mark Seielstad [Singapour, États-Unis] ; A. Hillary Steinhart [Canada] ; Stephan R. Targan [États-Unis] ; Leonard H. Van Den Berg [Pays-Bas] ; Morten Vatn [Norvège] ; Hein Verspaget [Pays-Bas] ; Thomas Walters [Canada] ; Cisca Wijmenga [Pays-Bas] ; David C. Wilson [Royaume-Uni] ; Harm-Jan Westra [Pays-Bas] ; Ramnik J. Xavier [États-Unis] ; Zhen Z. Zhao [Australie] ; Cyriel Y. Ponsioen [Pays-Bas] ; Vibeke Andersen [Danemark] ; Leif Torkvist [Suède] ; Maria Gazouli [Grèce] ; Nicholas P. Anagnou [Grèce] ; Tom H. Karlsen [Norvège] ; Limas Kupcinskas [Lituanie] ; Jurgita Sventoraityte [Lituanie] ; John C. Mansfield [Royaume-Uni] ; Subra Kugathasan [États-Unis] ; Mark S. Silverberg [Canada] ; Jonas Halfvarson [Suède] ; Jerome I. Rotter [États-Unis] ; Christopher G. Mathew [Royaume-Uni] ; Anne M. Griffiths [Canada] ; Richard Gearry [Nouvelle-Zélande] ; Tariq Ahmad [Royaume-Uni] ; Steven R. Brant [États-Unis] ; Mathias Chamaillard [France] ; Jack Satsangi [Royaume-Uni] ; Judy H. Cho [États-Unis] ; Stefan Schreiber [Allemagne] ; Mark J. Daly [États-Unis] ; Jeffrey C. Barrett [Royaume-Uni] ; Miles Parkes [Royaume-Uni] ; Vito Annese [Italie] ; Hakon Hakonarson [États-Unis] ; Graham Radford-Smith [Australie] ; Richard H. Duerr [États-Unis] ; Séverine Vermeire [Belgique] ; Rinse K. Weersma [Pays-Bas] ; John D. Rioux [Canada]Source :
- Nature genetics [ 1061-4036 ] ; 2011.
Abstract
Genome-wide association studies (GWAS) and candidate gene studies in ulcerative colitis (UC) have identified 18 susceptibility loci. We conducted a meta-analysis of 6 UC GWAS, comprising 6,687 cases and 19,718 controls, and followed-up the top association signals in 9,628 cases and 12,917 controls. We identified 29 additional risk loci (P<5×10-8), increasing the number of UC associated loci to 47. After annotating associated regions using GRAIL, eQTL data and correlations with non-synonymous SNPs, we identified many candidate genes providing potentially important insights into disease pathogenesis, including
Url:
DOI: 10.1038/ng.764
PubMed: 21297633
PubMed Central: 3084597
Affiliations:
- Allemagne, Australie, Belgique, Canada, Danemark, Espagne, France, Grèce, Israël, Italie, Lituanie, Norvège, Nouvelle-Zélande, Pays-Bas, Royaume-Uni, Singapour, Suisse, Suède, États-Unis
- Angleterre, Angleterre de l'Est, Attique (région), Bavière, Berlin, Californie, Canton de Berne, Catalogne, Connecticut, District de Haute-Bavière, Grand Est, Grand Londres, Grand Manchester, Groningue (province), Géorgie (États-Unis), Hauts-de-France, Hollande-Méridionale, Hollande-Septentrionale, Illinois, Lorraine (région), Maryland, Massachusetts, Nord-Pas-de-Calais, Ohio, Ontario, Pennsylvanie, Province de Liège, Région de Bruxelles-Capitale, Région wallonne, Schleswig-Holstein, Svealand, Utah, Utrecht (province), Washington (État), Écosse, Île-de-France, Østlandet
- Amsterdam, Athènes, Barcelone, Berlin, Berne, Bruxelles, Cambridge, Groningue, Kiel, Leyde, Lille, Liège, Londres, Manchester, Munich, Nancy, Oslo, Paris, Seattle, Stockholm, Toronto, Utrecht, Vandœuvre-lès-Nancy, Édimbourg
- Université d'Édimbourg, Université de Berne, Université de Cambridge, Université de Liège, Université de Toronto, Université de Washington
Links toward previous steps (curation, corpus...)
Links to Exploration step
PMC:3084597Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47</title><author><name sortKey="Anderson, Carl A" sort="Anderson, Carl A" uniqKey="Anderson C" first="Carl A." last="Anderson">Carl A. Anderson</name><affiliation wicri:level="1"><nlm:aff id="A1">Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Boucher, Gabrielle" sort="Boucher, Gabrielle" uniqKey="Boucher G" first="Gabrielle" last="Boucher">Gabrielle Boucher</name><affiliation wicri:level="1"><nlm:aff id="A2">Université de Montréal, Medicine, Montréal, Québec, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Université de Montréal, Medicine, Montréal, Québec</wicri:regionArea><wicri:noRegion>Québec</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A3">Montreal Heart Institute, Research Center, Montréal, Québec, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Montreal Heart Institute, Research Center, Montréal, Québec</wicri:regionArea><wicri:noRegion>Québec</wicri:noRegion></affiliation></author><author><name sortKey="Lees, Charlie W" sort="Lees, Charlie W" uniqKey="Lees C" first="Charlie W." last="Lees">Charlie W. Lees</name><affiliation wicri:level="4"><nlm:aff id="A4">University of Edinburgh, Western General Hospital, Gastrointestinal Unit, Molecular Medicine Centre, Edinburgh, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University of Edinburgh, Western General Hospital, Gastrointestinal Unit, Molecular Medicine Centre, Edinburgh</wicri:regionArea><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region><settlement type="city">Édimbourg</settlement></placeName><orgName type="university">Université d'Édimbourg</orgName></affiliation></author><author><name sortKey="Franke, Andre" sort="Franke, Andre" uniqKey="Franke A" first="Andre" last="Franke">Andre Franke</name><affiliation wicri:level="3"><nlm:aff id="A5">Christian-Albrechts-University Kiel, Institute of Clinical Molecular Biology, Kiel, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Christian-Albrechts-University Kiel, Institute of Clinical Molecular Biology, Kiel</wicri:regionArea><placeName><region type="land" nuts="2">Schleswig-Holstein</region><settlement type="city">Kiel</settlement></placeName></affiliation></author><author><name sortKey="D Mato, Mauro" sort="D Mato, Mauro" uniqKey="D Mato M" first="Mauro" last="D Mato">Mauro D Mato</name><affiliation wicri:level="3"><nlm:aff id="A6">Karolinska Institute, Department of Biosciences and Nutrition, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Karolinska Institute, Department of Biosciences and Nutrition, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Taylor, Kent D" sort="Taylor, Kent D" uniqKey="Taylor K" first="Kent D." last="Taylor">Kent D. Taylor</name><affiliation wicri:level="2"><nlm:aff id="A7">Cedars-Sinai Medical Center, Inflammatory Bowel and Immunobiology Research Institute, Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cedars-Sinai Medical Center, Inflammatory Bowel and Immunobiology Research Institute, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Lee, James C" sort="Lee, James C" uniqKey="Lee J" first="James C." last="Lee">James C. Lee</name><affiliation wicri:level="4"><nlm:aff id="A8">Addenbrooke’s Hospital, University of Cambridge, Gastroenterology Research Unit, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Addenbrooke’s Hospital, University of Cambridge, Gastroenterology Research Unit, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Goyette, Philippe" sort="Goyette, Philippe" uniqKey="Goyette P" first="Philippe" last="Goyette">Philippe Goyette</name><affiliation wicri:level="1"><nlm:aff id="A2">Université de Montréal, Medicine, Montréal, Québec, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Université de Montréal, Medicine, Montréal, Québec</wicri:regionArea><wicri:noRegion>Québec</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A3">Montreal Heart Institute, Research Center, Montréal, Québec, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Montreal Heart Institute, Research Center, Montréal, Québec</wicri:regionArea><wicri:noRegion>Québec</wicri:noRegion></affiliation></author><author><name sortKey="Imielinski, Marcin" sort="Imielinski, Marcin" uniqKey="Imielinski M" first="Marcin" last="Imielinski">Marcin Imielinski</name><affiliation wicri:level="2"><nlm:aff id="A9">The Children’s Hospital of Philadelphia, Center for Applied Genomics, Philadelphia, Pennsylvania, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Children’s Hospital of Philadelphia, Center for Applied Genomics, Philadelphia, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Latiano, Anna" sort="Latiano, Anna" uniqKey="Latiano A" first="Anna" last="Latiano">Anna Latiano</name><affiliation wicri:level="1"><nlm:aff id="A10">IRCCS-CSS Hospital, Unit of Gastroenterology, San Giovanni Rotondo, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>IRCCS-CSS Hospital, Unit of Gastroenterology, San Giovanni Rotondo</wicri:regionArea><wicri:noRegion>San Giovanni Rotondo</wicri:noRegion></affiliation></author><author><name sortKey="Lagace, Caroline" sort="Lagace, Caroline" uniqKey="Lagace C" first="Caroline" last="Lagacé">Caroline Lagacé</name><affiliation wicri:level="1"><nlm:aff id="A2">Université de Montréal, Medicine, Montréal, Québec, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Université de Montréal, Medicine, Montréal, Québec</wicri:regionArea><wicri:noRegion>Québec</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A3">Montreal Heart Institute, Research Center, Montréal, Québec, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Montreal Heart Institute, Research Center, Montréal, Québec</wicri:regionArea><wicri:noRegion>Québec</wicri:noRegion></affiliation></author><author><name sortKey="Scott, Regan" sort="Scott, Regan" uniqKey="Scott R" first="Regan" last="Scott">Regan Scott</name><affiliation wicri:level="2"><nlm:aff id="A11">University of Pittsburgh School of Medicine, Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Pittsburgh, Pennsylvania, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Pittsburgh School of Medicine, Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Pittsburgh, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Amininejad, Leila" sort="Amininejad, Leila" uniqKey="Amininejad L" first="Leila" last="Amininejad">Leila Amininejad</name><affiliation wicri:level="3"><nlm:aff id="A12">Erasmus Hospital, Free University of Brussels, Department of Gastroenterology, Brussels, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Erasmus Hospital, Free University of Brussels, Department of Gastroenterology, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation></author><author><name sortKey="Bumpstead, Suzannah" sort="Bumpstead, Suzannah" uniqKey="Bumpstead S" first="Suzannah" last="Bumpstead">Suzannah Bumpstead</name><affiliation wicri:level="1"><nlm:aff id="A1">Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Baidoo, Leonard" sort="Baidoo, Leonard" uniqKey="Baidoo L" first="Leonard" last="Baidoo">Leonard Baidoo</name><affiliation wicri:level="2"><nlm:aff id="A11">University of Pittsburgh School of Medicine, Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Pittsburgh, Pennsylvania, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Pittsburgh School of Medicine, Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Pittsburgh, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Baldassano, Robert N" sort="Baldassano, Robert N" uniqKey="Baldassano R" first="Robert N." last="Baldassano">Robert N. Baldassano</name><affiliation wicri:level="2"><nlm:aff id="A13">The Children’s Hospital of Philadelphia, Department of Pediatrics, Center for Pediatric Inflammatory Bowel Disease, Philadelphia, Pennsylvania, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Children’s Hospital of Philadelphia, Department of Pediatrics, Center for Pediatric Inflammatory Bowel Disease, Philadelphia, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Barclay, Murray" sort="Barclay, Murray" uniqKey="Barclay M" first="Murray" last="Barclay">Murray Barclay</name><affiliation wicri:level="1"><nlm:aff id="A14">University of Otago, Department of Medicine, Christchurch, New Zealand</nlm:aff><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea>University of Otago, Department of Medicine, Christchurch</wicri:regionArea><wicri:noRegion>Christchurch</wicri:noRegion></affiliation></author><author><name sortKey="Bayless, Theodore M" sort="Bayless, Theodore M" uniqKey="Bayless T" first="Theodore M." last="Bayless">Theodore M. Bayless</name><affiliation wicri:level="2"><nlm:aff id="A15">Johns Hopkins University School of Medicine, Meyeroff Inflammatory Bowel Disease Center, Dept. of Medicine, Baltimore, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Johns Hopkins University School of Medicine, Meyeroff Inflammatory Bowel Disease Center, Dept. of Medicine, Baltimore, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Brand, Stephan" sort="Brand, Stephan" uniqKey="Brand S" first="Stephan" last="Brand">Stephan Brand</name><affiliation wicri:level="3"><nlm:aff id="A16">University Hospital Munich, Department of Medicine II, Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Hospital Munich, Department of Medicine II, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Buning, Carsten" sort="Buning, Carsten" uniqKey="Buning C" first="Carsten" last="Büning">Carsten Büning</name><affiliation wicri:level="3"><nlm:aff id="A17">Universitätsmedizin Berlin, Department of Gastroenterology, Charité, Campus Mitte, Berlin, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Universitätsmedizin Berlin, Department of Gastroenterology, Charité, Campus Mitte, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Colombel, Jean Frederic" sort="Colombel, Jean Frederic" uniqKey="Colombel J" first="Jean-Frédéric" last="Colombel">Jean-Frédéric Colombel</name><affiliation wicri:level="3"><nlm:aff id="A18">Université de Lille Department of Hepato-Gastroenterology, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université de Lille Department of Hepato-Gastroenterology, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Denson, Lee A" sort="Denson, Lee A" uniqKey="Denson L" first="Lee A." last="Denson">Lee A. Denson</name><affiliation wicri:level="2"><nlm:aff id="A19">Cincinnati Children’s Hospital Medical Center, Pediatric Gastroenterology, Cincinnati, Ohio, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cincinnati Children’s Hospital Medical Center, Pediatric Gastroenterology, Cincinnati, Ohio</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="De Vos, Martine" sort="De Vos, Martine" uniqKey="De Vos M" first="Martine" last="De Vos">Martine De Vos</name><affiliation wicri:level="1"><nlm:aff id="A20">Ghent University Hospital, Department of Hepatology and Gastroenterology, Ghent, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Ghent University Hospital, Department of Hepatology and Gastroenterology, Ghent</wicri:regionArea><wicri:noRegion>Ghent</wicri:noRegion></affiliation></author><author><name sortKey="Dubinsky, Marla" sort="Dubinsky, Marla" uniqKey="Dubinsky M" first="Marla" last="Dubinsky">Marla Dubinsky</name><affiliation wicri:level="2"><nlm:aff id="A21">Cedars-Sinai Medical Center, Department of Pediatrics, Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cedars-Sinai Medical Center, Department of Pediatrics, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Edwards, Cathryn" sort="Edwards, Cathryn" uniqKey="Edwards C" first="Cathryn" last="Edwards">Cathryn Edwards</name><affiliation wicri:level="1"><nlm:aff id="A22">Torbay Hospital, Department of Gastroenterology, Torbay, Devon, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Torbay Hospital, Department of Gastroenterology, Torbay, Devon</wicri:regionArea><wicri:noRegion>Devon</wicri:noRegion></affiliation></author><author><name sortKey="Ellinghaus, David" sort="Ellinghaus, David" uniqKey="Ellinghaus D" first="David" last="Ellinghaus">David Ellinghaus</name><affiliation wicri:level="3"><nlm:aff id="A5">Christian-Albrechts-University Kiel, Institute of Clinical Molecular Biology, Kiel, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Christian-Albrechts-University Kiel, Institute of Clinical Molecular Biology, Kiel</wicri:regionArea><placeName><region type="land" nuts="2">Schleswig-Holstein</region><settlement type="city">Kiel</settlement></placeName></affiliation></author><author><name sortKey="Fehrmann, Rudolf S N" sort="Fehrmann, Rudolf S N" uniqKey="Fehrmann R" first="Rudolf S. N." last="Fehrmann">Rudolf S. N. Fehrmann</name><affiliation wicri:level="3"><nlm:aff id="A23">University Medical Center Groningen, Department of Genetics, Groningen, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>University Medical Center Groningen, Department of Genetics, Groningen</wicri:regionArea><placeName><settlement type="city">Groningue</settlement><region nuts="2" type="province">Groningue (province)</region></placeName></affiliation></author><author><name sortKey="Floyd, James A B" sort="Floyd, James A B" uniqKey="Floyd J" first="James A. B." last="Floyd">James A. B. Floyd</name><affiliation wicri:level="1"><nlm:aff id="A1">Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Florin, Tim" sort="Florin, Tim" uniqKey="Florin T" first="Tim" last="Florin">Tim Florin</name><affiliation wicri:level="1"><nlm:aff id="A24">Mater Health Services, Department of Gastroenterology, Brisbane, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Mater Health Services, Department of Gastroenterology, Brisbane</wicri:regionArea><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Franchimont, Denis" sort="Franchimont, Denis" uniqKey="Franchimont D" first="Denis" last="Franchimont">Denis Franchimont</name><affiliation wicri:level="3"><nlm:aff id="A25">Erasmus Hospital, Free University of Brussels, Department of Gastroenterology, Brussels, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Erasmus Hospital, Free University of Brussels, Department of Gastroenterology, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation></author><author><name sortKey="Franke, Lude" sort="Franke, Lude" uniqKey="Franke L" first="Lude" last="Franke">Lude Franke</name><affiliation wicri:level="3"><nlm:aff id="A23">University Medical Center Groningen, Department of Genetics, Groningen, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>University Medical Center Groningen, Department of Genetics, Groningen</wicri:regionArea><placeName><settlement type="city">Groningue</settlement><region nuts="2" type="province">Groningue (province)</region></placeName></affiliation></author><author><name sortKey="Georges, Michel" sort="Georges, Michel" uniqKey="Georges M" first="Michel" last="Georges">Michel Georges</name><affiliation wicri:level="4"><nlm:aff id="A26">University of Liège, Department of Genetics, Faculty of Veterinary Medicine, Liège, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>University of Liège, Department of Genetics, Faculty of Veterinary Medicine, Liège</wicri:regionArea><orgName type="university">Université de Liège</orgName><placeName><settlement type="city">Liège</settlement><region type="region" nuts="1">Région wallonne</region><region type="province" nuts="1">Province de Liège</region></placeName></affiliation></author><author><name sortKey="Glas, Jurgen" sort="Glas, Jurgen" uniqKey="Glas J" first="Jürgen" last="Glas">Jürgen Glas</name><affiliation wicri:level="3"><nlm:aff id="A16">University Hospital Munich, Department of Medicine II, Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Hospital Munich, Department of Medicine II, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Glazer, Nicole L" sort="Glazer, Nicole L" uniqKey="Glazer N" first="Nicole L." last="Glazer">Nicole L. Glazer</name><affiliation wicri:level="4"><nlm:aff id="A27">University of Washington, Cardiovascular Health Research Unit, Department of Internal Medicine, Seattle, Washington, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Washington, Cardiovascular Health Research Unit, Department of Internal Medicine, Seattle, Washington</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Guthery, Stephen L" sort="Guthery, Stephen L" uniqKey="Guthery S" first="Stephen L." last="Guthery">Stephen L. Guthery</name><affiliation wicri:level="2"><nlm:aff id="A28">University of Utah School of Medicine, Department of Pediatrics, Salt Lake City, Utah, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Utah School of Medicine, Department of Pediatrics, Salt Lake City, Utah</wicri:regionArea><placeName><region type="state">Utah</region></placeName></affiliation></author><author><name sortKey="Haritunians, Talin" sort="Haritunians, Talin" uniqKey="Haritunians T" first="Talin" last="Haritunians">Talin Haritunians</name><affiliation wicri:level="2"><nlm:aff id="A29">Cedars-Sinai Medical Center, Medical Genetics Institute, Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cedars-Sinai Medical Center, Medical Genetics Institute, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Hayward, Nicholas K" sort="Hayward, Nicholas K" uniqKey="Hayward N" first="Nicholas K." last="Hayward">Nicholas K. Hayward</name><affiliation wicri:level="1"><nlm:aff id="A30">Queensland Institute of Medical Research, Genetic Epidemiology, Brisbane, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research, Genetic Epidemiology, Brisbane</wicri:regionArea><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Hugot, Jean Pierre" sort="Hugot, Jean Pierre" uniqKey="Hugot J" first="Jean-Pierre" last="Hugot">Jean-Pierre Hugot</name><affiliation wicri:level="3"><nlm:aff id="A31">Université Paris Diderot & INSERM & Hopital Robert Debre APHP, Gastroenterology, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Paris Diderot & INSERM & Hopital Robert Debre APHP, Gastroenterology, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Jobin, Gilles" sort="Jobin, Gilles" uniqKey="Jobin G" first="Gilles" last="Jobin">Gilles Jobin</name><affiliation wicri:level="1"><nlm:aff id="A2">Université de Montréal, Medicine, Montréal, Québec, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Université de Montréal, Medicine, Montréal, Québec</wicri:regionArea><wicri:noRegion>Québec</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A32">Hôpital Maisonneuve-Rosemont, Dept of Gastroenterology, Montréal, Québec, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Hôpital Maisonneuve-Rosemont, Dept of Gastroenterology, Montréal, Québec</wicri:regionArea><wicri:noRegion>Québec</wicri:noRegion></affiliation></author><author><name sortKey="Laukens, Debby" sort="Laukens, Debby" uniqKey="Laukens D" first="Debby" last="Laukens">Debby Laukens</name><affiliation wicri:level="1"><nlm:aff id="A20">Ghent University Hospital, Department of Hepatology and Gastroenterology, Ghent, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Ghent University Hospital, Department of Hepatology and Gastroenterology, Ghent</wicri:regionArea><wicri:noRegion>Ghent</wicri:noRegion></affiliation></author><author><name sortKey="Lawrance, Ian" sort="Lawrance, Ian" uniqKey="Lawrance I" first="Ian" last="Lawrance">Ian Lawrance</name><affiliation wicri:level="1"><nlm:aff id="A33">The University of Western Australia, School of Medicine and Pharmacology, Fremantle, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>The University of Western Australia, School of Medicine and Pharmacology, Fremantle</wicri:regionArea><wicri:noRegion>Fremantle</wicri:noRegion></affiliation></author><author><name sortKey="Lemann, Marc" sort="Lemann, Marc" uniqKey="Lemann M" first="Marc" last="Lémann">Marc Lémann</name><affiliation wicri:level="3"><nlm:aff id="A34">Université Paris Diderot, GETAID group, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Paris Diderot, GETAID group, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Levine, Arie" sort="Levine, Arie" uniqKey="Levine A" first="Arie" last="Levine">Arie Levine</name><affiliation wicri:level="1"><nlm:aff id="A35">Tel Aviv University, Pediatric Gastroenterology Unit, Wolfson Medical Center and Sackler School of Medicine, Tel Aviv, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Tel Aviv University, Pediatric Gastroenterology Unit, Wolfson Medical Center and Sackler School of Medicine, Tel Aviv</wicri:regionArea><wicri:noRegion>Tel Aviv</wicri:noRegion></affiliation></author><author><name sortKey="Libioulle, Cecile" sort="Libioulle, Cecile" uniqKey="Libioulle C" first="Cecile" last="Libioulle">Cecile Libioulle</name><affiliation wicri:level="1"><nlm:aff id="A36">Centre Hospitalier Universitaire Université de Liège, Division of Gastroenterology, Liège, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Centre Hospitalier Universitaire Université de Liège, Division of Gastroenterology, Liège</wicri:regionArea><wicri:noRegion>Liège</wicri:noRegion></affiliation></author><author><name sortKey="Louis, Edouard" sort="Louis, Edouard" uniqKey="Louis E" first="Edouard" last="Louis">Edouard Louis</name><affiliation wicri:level="1"><nlm:aff id="A36">Centre Hospitalier Universitaire Université de Liège, Division of Gastroenterology, Liège, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Centre Hospitalier Universitaire Université de Liège, Division of Gastroenterology, Liège</wicri:regionArea><wicri:noRegion>Liège</wicri:noRegion></affiliation></author><author><name sortKey="Mcgovern, Dermot P" sort="Mcgovern, Dermot P" uniqKey="Mcgovern D" first="Dermot P." last="Mcgovern">Dermot P. Mcgovern</name><affiliation wicri:level="2"><nlm:aff id="A7">Cedars-Sinai Medical Center, Inflammatory Bowel and Immunobiology Research Institute, Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cedars-Sinai Medical Center, Inflammatory Bowel and Immunobiology Research Institute, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A29">Cedars-Sinai Medical Center, Medical Genetics Institute, Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cedars-Sinai Medical Center, Medical Genetics Institute, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Milla, Monica" sort="Milla, Monica" uniqKey="Milla M" first="Monica" last="Milla">Monica Milla</name><affiliation wicri:level="1"><nlm:aff id="A37">AOU Careggi, Unit of Gastroenterology SOD2, Florence, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>AOU Careggi, Unit of Gastroenterology SOD2, Florence</wicri:regionArea><wicri:noRegion>Florence</wicri:noRegion></affiliation></author><author><name sortKey="Montgomery, Grant W" sort="Montgomery, Grant W" uniqKey="Montgomery G" first="Grant W." last="Montgomery">Grant W. Montgomery</name><affiliation wicri:level="1"><nlm:aff id="A30">Queensland Institute of Medical Research, Genetic Epidemiology, Brisbane, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research, Genetic Epidemiology, Brisbane</wicri:regionArea><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Morley, Katherine I" sort="Morley, Katherine I" uniqKey="Morley K" first="Katherine I." last="Morley">Katherine I. Morley</name><affiliation wicri:level="1"><nlm:aff id="A1">Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Mowat, Craig" sort="Mowat, Craig" uniqKey="Mowat C" first="Craig" last="Mowat">Craig Mowat</name><affiliation wicri:level="1"><nlm:aff id="A38">Ninewells Hospital and Medical School, Dept of Medicine, Dundee, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Ninewells Hospital and Medical School, Dept of Medicine, Dundee</wicri:regionArea><wicri:noRegion>Dundee</wicri:noRegion></affiliation></author><author><name sortKey="Ng, Aylwin" sort="Ng, Aylwin" uniqKey="Ng A" first="Aylwin" last="Ng">Aylwin Ng</name><affiliation wicri:level="2"><nlm:aff id="A39">Massachusetts General Hospital, Harvard Medical School, Gastroenterology Unit Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Massachusetts General Hospital, Harvard Medical School, Gastroenterology Unit Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A40">Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Newman, William" sort="Newman, William" uniqKey="Newman W" first="William" last="Newman">William Newman</name><affiliation wicri:level="3"><nlm:aff id="A41">University of Manchester Department of Medical Genetics, Manchester, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University of Manchester Department of Medical Genetics, Manchester</wicri:regionArea><placeName><settlement type="city">Manchester</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Manchester</region></placeName></affiliation></author><author><name sortKey="Ophoff, Roel A" sort="Ophoff, Roel A" uniqKey="Ophoff R" first="Roel A" last="Ophoff">Roel A. Ophoff</name><affiliation wicri:level="3"><nlm:aff id="A42">University Medical Center Utrecht, Department of Medical Genetics, Utrecht, Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>University Medical Center Utrecht, Department of Medical Genetics, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Papi, Laura" sort="Papi, Laura" uniqKey="Papi L" first="Laura" last="Papi">Laura Papi</name><affiliation wicri:level="1"><nlm:aff id="A43">University of Florence, Institute of Human Genetics, Florence, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>University of Florence, Institute of Human Genetics, Florence</wicri:regionArea><wicri:noRegion>Florence</wicri:noRegion></affiliation></author><author><name sortKey="Palmieri, Orazio" sort="Palmieri, Orazio" uniqKey="Palmieri O" first="Orazio" last="Palmieri">Orazio Palmieri</name><affiliation wicri:level="1"><nlm:aff id="A10">IRCCS-CSS Hospital, Unit of Gastroenterology, San Giovanni Rotondo, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>IRCCS-CSS Hospital, Unit of Gastroenterology, San Giovanni Rotondo</wicri:regionArea><wicri:noRegion>San Giovanni Rotondo</wicri:noRegion></affiliation></author><author><name sortKey="Peyrin Biroulet, Laurent" sort="Peyrin Biroulet, Laurent" uniqKey="Peyrin Biroulet L" first="Laurent" last="Peyrin-Biroulet">Laurent Peyrin-Biroulet</name><affiliation wicri:level="3"><nlm:aff id="A44">University Hospital of Nancy, Department of Hepato-Gastroenterology, Vandoeuvre-lès-Nancy, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>University Hospital of Nancy, Department of Hepato-Gastroenterology, Vandoeuvre-lès-Nancy</wicri:regionArea><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Lorraine (région)</region><settlement type="city">Vandœuvre-lès-Nancy</settlement><settlement type="city" wicri:auto="agglo">Nancy</settlement></placeName></affiliation></author><author><name sortKey="Panes, Julian" sort="Panes, Julian" uniqKey="Panes J" first="Julián" last="Panés">Julián Panés</name><affiliation wicri:level="3"><nlm:aff id="A45">Hospital Clínic de Barcelona, IDIBAPS, CIBERehd, Department of Gastroenterology, Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital Clínic de Barcelona, IDIBAPS, CIBERehd, Department of Gastroenterology, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Phillips, Anne" sort="Phillips, Anne" uniqKey="Phillips A" first="Anne" last="Phillips">Anne Phillips</name><affiliation wicri:level="1"><nlm:aff id="A38">Ninewells Hospital and Medical School, Dept of Medicine, Dundee, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Ninewells Hospital and Medical School, Dept of Medicine, Dundee</wicri:regionArea><wicri:noRegion>Dundee</wicri:noRegion></affiliation></author><author><name sortKey="Prescott, Natalie J" sort="Prescott, Natalie J" uniqKey="Prescott N" first="Natalie J." last="Prescott">Natalie J. Prescott</name><affiliation wicri:level="3"><nlm:aff id="A46">King’s College London School of Medicine, Guy’s Hospital, Department of Medical and Molecular Genetics, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>King’s College London School of Medicine, Guy’s Hospital, Department of Medical and Molecular Genetics, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Proctor, Deborah D" sort="Proctor, Deborah D" uniqKey="Proctor D" first="Deborah D." last="Proctor">Deborah D. Proctor</name><affiliation wicri:level="2"><nlm:aff id="A47">Yale University, Section of Digestive Diseases, Department of Medicine, New Haven, Connecticut, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Yale University, Section of Digestive Diseases, Department of Medicine, New Haven, Connecticut</wicri:regionArea><placeName><region type="state">Connecticut</region></placeName></affiliation></author><author><name sortKey="Roberts, Rebecca" sort="Roberts, Rebecca" uniqKey="Roberts R" first="Rebecca" last="Roberts">Rebecca Roberts</name><affiliation wicri:level="1"><nlm:aff id="A14">University of Otago, Department of Medicine, Christchurch, New Zealand</nlm:aff><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea>University of Otago, Department of Medicine, Christchurch</wicri:regionArea><wicri:noRegion>Christchurch</wicri:noRegion></affiliation></author><author><name sortKey="Russell, Richard" sort="Russell, Richard" uniqKey="Russell R" first="Richard" last="Russell">Richard Russell</name><affiliation wicri:level="1"><nlm:aff id="A48">Royal Hospital for Sick Children, Paediatric Gastroenterology and Nutrition, Glasgow, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Royal Hospital for Sick Children, Paediatric Gastroenterology and Nutrition, Glasgow</wicri:regionArea><wicri:noRegion>Glasgow</wicri:noRegion></affiliation></author><author><name sortKey="Rutgeerts, Paul" sort="Rutgeerts, Paul" uniqKey="Rutgeerts P" first="Paul" last="Rutgeerts">Paul Rutgeerts</name><affiliation wicri:level="1"><nlm:aff id="A49">University Hospital Gasthuisberg, Division of Gastroenterology, Leuven, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>University Hospital Gasthuisberg, Division of Gastroenterology, Leuven</wicri:regionArea><wicri:noRegion>Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Sanderson, Jeremy" sort="Sanderson, Jeremy" uniqKey="Sanderson J" first="Jeremy" last="Sanderson">Jeremy Sanderson</name><affiliation wicri:level="3"><nlm:aff id="A50">Guy’s & St Thomas’ NHS Foundation Trust, St Thomas’ Hospital, Dept Gastroenterology, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Guy’s & St Thomas’ NHS Foundation Trust, St Thomas’ Hospital, Dept Gastroenterology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Sans, Miquel" sort="Sans, Miquel" uniqKey="Sans M" first="Miquel" last="Sans">Miquel Sans</name><affiliation wicri:level="3"><nlm:aff id="A51">Hospital Clínic de Barcelona, IDIBAPS, CIBERehd, Department of Gastroenterology, Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital Clínic de Barcelona, IDIBAPS, CIBERehd, Department of Gastroenterology, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Schumm, Philip" sort="Schumm, Philip" uniqKey="Schumm P" first="Philip" last="Schumm">Philip Schumm</name><affiliation wicri:level="2"><nlm:aff id="A52">University of Chicago, Department of Health Studies, Chicago, Illinois, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Chicago, Department of Health Studies, Chicago, Illinois</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Seibold, Frank" sort="Seibold, Frank" uniqKey="Seibold F" first="Frank" last="Seibold">Frank Seibold</name><affiliation wicri:level="4"><nlm:aff id="A53">University of Bern, Division of Gastroenterology, Inselspital, Bern, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>University of Bern, Division of Gastroenterology, Inselspital, Bern</wicri:regionArea><placeName><settlement type="city">Berne</settlement><region type="région" nuts="3">Canton de Berne</region><settlement type="city">Berne</settlement></placeName><orgName type="university">Université de Berne</orgName></affiliation></author><author><name sortKey="Sharma, Yashoda" sort="Sharma, Yashoda" uniqKey="Sharma Y" first="Yashoda" last="Sharma">Yashoda Sharma</name><affiliation wicri:level="2"><nlm:aff id="A47">Yale University, Section of Digestive Diseases, Department of Medicine, New Haven, Connecticut, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Yale University, Section of Digestive Diseases, Department of Medicine, New Haven, Connecticut</wicri:regionArea><placeName><region type="state">Connecticut</region></placeName></affiliation></author><author><name sortKey="Simms, Lisa" sort="Simms, Lisa" uniqKey="Simms L" first="Lisa" last="Simms">Lisa Simms</name><affiliation wicri:level="1"><nlm:aff id="A30">Queensland Institute of Medical Research, Genetic Epidemiology, Brisbane, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research, Genetic Epidemiology, Brisbane</wicri:regionArea><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Seielstad, Mark" sort="Seielstad, Mark" uniqKey="Seielstad M" first="Mark" last="Seielstad">Mark Seielstad</name><affiliation wicri:level="1"><nlm:aff id="A54">Genome Institute of Singapore, Human Genetics, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Genome Institute of Singapore, Human Genetics</wicri:regionArea><wicri:noRegion>Human Genetics</wicri:noRegion></affiliation><affiliation wicri:level="2"><nlm:aff id="A55">Institute for Human Genetics, University of California San Fransisco, San Francisco, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institute for Human Genetics, University of California San Fransisco, San Francisco, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Steinhart, A Hillary" sort="Steinhart, A Hillary" uniqKey="Steinhart A" first="A. Hillary" last="Steinhart">A. Hillary Steinhart</name><affiliation wicri:level="4"><nlm:aff id="A56">University of Toronto, Mount Sinai Hospital Inflammatory Bowel Disease Centre, Toronto, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>University of Toronto, Mount Sinai Hospital Inflammatory Bowel Disease Centre, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Targan, Stephan R" sort="Targan, Stephan R" uniqKey="Targan S" first="Stephan R." last="Targan">Stephan R. Targan</name><affiliation wicri:level="2"><nlm:aff id="A7">Cedars-Sinai Medical Center, Inflammatory Bowel and Immunobiology Research Institute, Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cedars-Sinai Medical Center, Inflammatory Bowel and Immunobiology Research Institute, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Van Den Berg, Leonard H" sort="Van Den Berg, Leonard H" uniqKey="Van Den Berg L" first="Leonard H." last="Van Den Berg">Leonard H. Van Den Berg</name><affiliation wicri:level="3"><nlm:aff id="A57">Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Department of Neurology, Utrecht, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Department of Neurology, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Vatn, Morten" sort="Vatn, Morten" uniqKey="Vatn M" first="Morten" last="Vatn">Morten Vatn</name><affiliation wicri:level="3"><nlm:aff id="A58">Rikshospitalet University Hospital, Medical Department, Oslo, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea>Rikshospitalet University Hospital, Medical Department, Oslo</wicri:regionArea><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation></author><author><name sortKey="Verspaget, Hein" sort="Verspaget, Hein" uniqKey="Verspaget H" first="Hein" last="Verspaget">Hein Verspaget</name><affiliation wicri:level="3"><nlm:aff id="A59">Leiden University Medical Center, Experimental Gastroenterology, Leiden, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Leiden University Medical Center, Experimental Gastroenterology, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Walters, Thomas" sort="Walters, Thomas" uniqKey="Walters T" first="Thomas" last="Walters">Thomas Walters</name><affiliation wicri:level="4"><nlm:aff id="A60">The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>The Hospital for Sick Children, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Wijmenga, Cisca" sort="Wijmenga, Cisca" uniqKey="Wijmenga C" first="Cisca" last="Wijmenga">Cisca Wijmenga</name><affiliation wicri:level="3"><nlm:aff id="A23">University Medical Center Groningen, Department of Genetics, Groningen, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>University Medical Center Groningen, Department of Genetics, Groningen</wicri:regionArea><placeName><settlement type="city">Groningue</settlement><region nuts="2" type="province">Groningue (province)</region></placeName></affiliation></author><author><name sortKey="Wilson, David C" sort="Wilson, David C" uniqKey="Wilson D" first="David C." last="Wilson">David C. Wilson</name><affiliation wicri:level="1"><nlm:aff id="A48">Royal Hospital for Sick Children, Paediatric Gastroenterology and Nutrition, Glasgow, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Royal Hospital for Sick Children, Paediatric Gastroenterology and Nutrition, Glasgow</wicri:regionArea><wicri:noRegion>Glasgow</wicri:noRegion></affiliation><affiliation wicri:level="2"><nlm:aff id="A61">Child Life and Health, University of Edinburgh, Scotland</nlm:aff><country>Royaume-Uni</country><placeName><region type="country">Écosse</region></placeName><wicri:cityArea>Child Life and Health, University of Edinburgh</wicri:cityArea></affiliation></author><author><name sortKey="Westra, Harm Jan" sort="Westra, Harm Jan" uniqKey="Westra H" first="Harm-Jan" last="Westra">Harm-Jan Westra</name><affiliation wicri:level="3"><nlm:aff id="A23">University Medical Center Groningen, Department of Genetics, Groningen, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>University Medical Center Groningen, Department of Genetics, Groningen</wicri:regionArea><placeName><settlement type="city">Groningue</settlement><region nuts="2" type="province">Groningue (province)</region></placeName></affiliation></author><author><name sortKey="Xavier, Ramnik J" sort="Xavier, Ramnik J" uniqKey="Xavier R" first="Ramnik J." last="Xavier">Ramnik J. Xavier</name><affiliation wicri:level="2"><nlm:aff id="A39">Massachusetts General Hospital, Harvard Medical School, Gastroenterology Unit Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Massachusetts General Hospital, Harvard Medical School, Gastroenterology Unit Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A40">Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Zhao, Zhen Z" sort="Zhao, Zhen Z" uniqKey="Zhao Z" first="Zhen Z." last="Zhao">Zhen Z. Zhao</name><affiliation wicri:level="1"><nlm:aff id="A30">Queensland Institute of Medical Research, Genetic Epidemiology, Brisbane, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research, Genetic Epidemiology, Brisbane</wicri:regionArea><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Ponsioen, Cyriel Y" sort="Ponsioen, Cyriel Y" uniqKey="Ponsioen C" first="Cyriel Y." last="Ponsioen">Cyriel Y. Ponsioen</name><affiliation wicri:level="3"><nlm:aff id="A62">Academic Medical Center, Department of Gastroenterology, Amsterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Academic Medical Center, Department of Gastroenterology, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Andersen, Vibeke" sort="Andersen, Vibeke" uniqKey="Andersen V" first="Vibeke" last="Andersen">Vibeke Andersen</name><affiliation wicri:level="1"><nlm:aff id="A63">Viborg Regional Hospital, Medical Department, Viborg, Denmark</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Viborg Regional Hospital, Medical Department, Viborg</wicri:regionArea><wicri:noRegion>Viborg</wicri:noRegion></affiliation></author><author><name sortKey="Torkvist, Leif" sort="Torkvist, Leif" uniqKey="Torkvist L" first="Leif" last="Torkvist">Leif Torkvist</name><affiliation wicri:level="3"><nlm:aff id="A64">Karolinska Institutet, Department of Clinical Science Intervention and Technology, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Karolinska Institutet, Department of Clinical Science Intervention and Technology, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Gazouli, Maria" sort="Gazouli, Maria" uniqKey="Gazouli M" first="Maria" last="Gazouli">Maria Gazouli</name><affiliation wicri:level="3"><nlm:aff id="A65">University of Athens, Department of Biology, School of Medicine, Athens, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>University of Athens, Department of Biology, School of Medicine, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Anagnou, Nicholas P" sort="Anagnou, Nicholas P" uniqKey="Anagnou N" first="Nicholas P." last="Anagnou">Nicholas P. Anagnou</name><affiliation wicri:level="3"><nlm:aff id="A65">University of Athens, Department of Biology, School of Medicine, Athens, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>University of Athens, Department of Biology, School of Medicine, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Karlsen, Tom H" sort="Karlsen, Tom H" uniqKey="Karlsen T" first="Tom H." last="Karlsen">Tom H. Karlsen</name><affiliation wicri:level="3"><nlm:aff id="A58">Rikshospitalet University Hospital, Medical Department, Oslo, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea>Rikshospitalet University Hospital, Medical Department, Oslo</wicri:regionArea><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation></author><author><name sortKey="Kupcinskas, Limas" sort="Kupcinskas, Limas" uniqKey="Kupcinskas L" first="Limas" last="Kupcinskas">Limas Kupcinskas</name><affiliation wicri:level="1"><nlm:aff id="A66">Kaunas University of medicine, Department of Gastroenterology, Kaunas, Lithuania</nlm:aff><country xml:lang="fr">Lituanie</country><wicri:regionArea>Kaunas University of medicine, Department of Gastroenterology, Kaunas</wicri:regionArea><wicri:noRegion>Kaunas</wicri:noRegion></affiliation></author><author><name sortKey="Sventoraityte, Jurgita" sort="Sventoraityte, Jurgita" uniqKey="Sventoraityte J" first="Jurgita" last="Sventoraityte">Jurgita Sventoraityte</name><affiliation wicri:level="1"><nlm:aff id="A66">Kaunas University of medicine, Department of Gastroenterology, Kaunas, Lithuania</nlm:aff><country xml:lang="fr">Lituanie</country><wicri:regionArea>Kaunas University of medicine, Department of Gastroenterology, Kaunas</wicri:regionArea><wicri:noRegion>Kaunas</wicri:noRegion></affiliation></author><author><name sortKey="Mansfield, John C" sort="Mansfield, John C" uniqKey="Mansfield J" first="John C." last="Mansfield">John C. Mansfield</name><affiliation wicri:level="1"><nlm:aff id="A67">Newcastle University, Institute of Human Genetics, Newcastle upon Tyne, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Newcastle University, Institute of Human Genetics, Newcastle upon Tyne</wicri:regionArea><wicri:noRegion>Newcastle upon Tyne</wicri:noRegion></affiliation></author><author><name sortKey="Kugathasan, Subra" sort="Kugathasan, Subra" uniqKey="Kugathasan S" first="Subra" last="Kugathasan">Subra Kugathasan</name><affiliation wicri:level="2"><nlm:aff id="A68">Emory School of Medicine, Department of Genetics and Department of Pediatrics, Atlanta, Georgia, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Emory School of Medicine, Department of Genetics and Department of Pediatrics, Atlanta, Georgia</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Silverberg, Mark S" sort="Silverberg, Mark S" uniqKey="Silverberg M" first="Mark S." last="Silverberg">Mark S. Silverberg</name><affiliation wicri:level="4"><nlm:aff id="A56">University of Toronto, Mount Sinai Hospital Inflammatory Bowel Disease Centre, Toronto, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>University of Toronto, Mount Sinai Hospital Inflammatory Bowel Disease Centre, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Halfvarson, Jonas" sort="Halfvarson, Jonas" uniqKey="Halfvarson J" first="Jonas" last="Halfvarson">Jonas Halfvarson</name><affiliation wicri:level="1"><nlm:aff id="A69">Örebro University Hospital, Department of Medicine, Örebro, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Örebro University Hospital, Department of Medicine, Örebro</wicri:regionArea><wicri:noRegion>Örebro</wicri:noRegion></affiliation></author><author><name sortKey="Rotter, Jerome I" sort="Rotter, Jerome I" uniqKey="Rotter J" first="Jerome I." last="Rotter">Jerome I. Rotter</name><affiliation wicri:level="2"><nlm:aff id="A29">Cedars-Sinai Medical Center, Medical Genetics Institute, Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cedars-Sinai Medical Center, Medical Genetics Institute, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Mathew, Christopher G" sort="Mathew, Christopher G" uniqKey="Mathew C" first="Christopher G." last="Mathew">Christopher G. Mathew</name><affiliation wicri:level="3"><nlm:aff id="A46">King’s College London School of Medicine, Guy’s Hospital, Department of Medical and Molecular Genetics, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>King’s College London School of Medicine, Guy’s Hospital, Department of Medical and Molecular Genetics, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Griffiths, Anne M" sort="Griffiths, Anne M" uniqKey="Griffiths A" first="Anne M." last="Griffiths">Anne M. Griffiths</name><affiliation wicri:level="4"><nlm:aff id="A60">The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>The Hospital for Sick Children, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Gearry, Richard" sort="Gearry, Richard" uniqKey="Gearry R" first="Richard" last="Gearry">Richard Gearry</name><affiliation wicri:level="1"><nlm:aff id="A14">University of Otago, Department of Medicine, Christchurch, New Zealand</nlm:aff><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea>University of Otago, Department of Medicine, Christchurch</wicri:regionArea><wicri:noRegion>Christchurch</wicri:noRegion></affiliation></author><author><name sortKey="Ahmad, Tariq" sort="Ahmad, Tariq" uniqKey="Ahmad T" first="Tariq" last="Ahmad">Tariq Ahmad</name><affiliation wicri:level="1"><nlm:aff id="A70">Peninsula College of Medicine and Dentistry, Barrack Road, Exeter, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Peninsula College of Medicine and Dentistry, Barrack Road, Exeter</wicri:regionArea><wicri:noRegion>Exeter</wicri:noRegion></affiliation></author><author><name sortKey="Brant, Steven R" sort="Brant, Steven R" uniqKey="Brant S" first="Steven R." last="Brant">Steven R. Brant</name><affiliation wicri:level="2"><nlm:aff id="A15">Johns Hopkins University School of Medicine, Meyeroff Inflammatory Bowel Disease Center, Dept. of Medicine, Baltimore, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Johns Hopkins University School of Medicine, Meyeroff Inflammatory Bowel Disease Center, Dept. of Medicine, Baltimore, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Chamaillard, Mathias" sort="Chamaillard, Mathias" uniqKey="Chamaillard M" first="Mathias" last="Chamaillard">Mathias Chamaillard</name><affiliation wicri:level="3"><nlm:aff id="A71">Inserm, U1019, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm, U1019, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Satsangi, Jack" sort="Satsangi, Jack" uniqKey="Satsangi J" first="Jack" last="Satsangi">Jack Satsangi</name><affiliation wicri:level="4"><nlm:aff id="A4">University of Edinburgh, Western General Hospital, Gastrointestinal Unit, Molecular Medicine Centre, Edinburgh, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University of Edinburgh, Western General Hospital, Gastrointestinal Unit, Molecular Medicine Centre, Edinburgh</wicri:regionArea><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region><settlement type="city">Édimbourg</settlement></placeName><orgName type="university">Université d'Édimbourg</orgName></affiliation></author><author><name sortKey="Cho, Judy H" sort="Cho, Judy H" uniqKey="Cho J" first="Judy H." last="Cho">Judy H. Cho</name><affiliation wicri:level="2"><nlm:aff id="A47">Yale University, Section of Digestive Diseases, Department of Medicine, New Haven, Connecticut, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Yale University, Section of Digestive Diseases, Department of Medicine, New Haven, Connecticut</wicri:regionArea><placeName><region type="state">Connecticut</region></placeName></affiliation><affiliation><nlm:aff id="A72">Yale University, Department of Genetics, Yale School of Medicine, New Haven CT</nlm:aff><wicri:noCountry code="subfield">New Haven CT</wicri:noCountry></affiliation></author><author><name sortKey="Schreiber, Stefan" sort="Schreiber, Stefan" uniqKey="Schreiber S" first="Stefan" last="Schreiber">Stefan Schreiber</name><affiliation wicri:level="3"><nlm:aff id="A5">Christian-Albrechts-University Kiel, Institute of Clinical Molecular Biology, Kiel, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Christian-Albrechts-University Kiel, Institute of Clinical Molecular Biology, Kiel</wicri:regionArea><placeName><region type="land" nuts="2">Schleswig-Holstein</region><settlement type="city">Kiel</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A73">Department for General Internal Medicine, Christian-Albrechts-University, Kiel, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department for General Internal Medicine, Christian-Albrechts-University, Kiel</wicri:regionArea><placeName><region type="land" nuts="2">Schleswig-Holstein</region><settlement type="city">Kiel</settlement></placeName></affiliation></author><author><name sortKey="Daly, Mark J" sort="Daly, Mark J" uniqKey="Daly M" first="Mark J." last="Daly">Mark J. Daly</name><affiliation wicri:level="2"><nlm:aff id="A74">Massachusetts General Hospital, Harvard Medical School, Center for Human Genetic Research, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Massachusetts General Hospital, Harvard Medical School, Center for Human Genetic Research, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Barrett, Jeffrey C" sort="Barrett, Jeffrey C" uniqKey="Barrett J" first="Jeffrey C." last="Barrett">Jeffrey C. Barrett</name><affiliation wicri:level="1"><nlm:aff id="A1">Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Parkes, Miles" sort="Parkes, Miles" uniqKey="Parkes M" first="Miles" last="Parkes">Miles Parkes</name><affiliation wicri:level="4"><nlm:aff id="A8">Addenbrooke’s Hospital, University of Cambridge, Gastroenterology Research Unit, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Addenbrooke’s Hospital, University of Cambridge, Gastroenterology Research Unit, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Annese, Vito" sort="Annese, Vito" uniqKey="Annese V" first="Vito" last="Annese">Vito Annese</name><affiliation wicri:level="1"><nlm:aff id="A10">IRCCS-CSS Hospital, Unit of Gastroenterology, San Giovanni Rotondo, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>IRCCS-CSS Hospital, Unit of Gastroenterology, San Giovanni Rotondo</wicri:regionArea><wicri:noRegion>San Giovanni Rotondo</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A37">AOU Careggi, Unit of Gastroenterology SOD2, Florence, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>AOU Careggi, Unit of Gastroenterology SOD2, Florence</wicri:regionArea><wicri:noRegion>Florence</wicri:noRegion></affiliation></author><author><name sortKey="Hakonarson, Hakon" sort="Hakonarson, Hakon" uniqKey="Hakonarson H" first="Hakon" last="Hakonarson">Hakon Hakonarson</name><affiliation wicri:level="2"><nlm:aff id="A13">The Children’s Hospital of Philadelphia, Department of Pediatrics, Center for Pediatric Inflammatory Bowel Disease, Philadelphia, Pennsylvania, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Children’s Hospital of Philadelphia, Department of Pediatrics, Center for Pediatric Inflammatory Bowel Disease, Philadelphia, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A75">Center for Applied Genomics, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Applied Genomics, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Radford Smith, Graham" sort="Radford Smith, Graham" uniqKey="Radford Smith G" first="Graham" last="Radford-Smith">Graham Radford-Smith</name><affiliation wicri:level="1"><nlm:aff id="A76">Queensland Institute of Medical Research, IBD Research Group, Brisbane, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research, IBD Research Group, Brisbane</wicri:regionArea><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Duerr, Richard H" sort="Duerr, Richard H" uniqKey="Duerr R" first="Richard H." last="Duerr">Richard H. Duerr</name><affiliation wicri:level="2"><nlm:aff id="A11">University of Pittsburgh School of Medicine, Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Pittsburgh, Pennsylvania, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Pittsburgh School of Medicine, Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Pittsburgh, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A77">University of Pittsburgh Graduate School of Public Health, 130 Desoto Street, Pittsburgh, PA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Pittsburgh Graduate School of Public Health, 130 Desoto Street, Pittsburgh, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Vermeire, Severine" sort="Vermeire, Severine" uniqKey="Vermeire S" first="Séverine" last="Vermeire">Séverine Vermeire</name><affiliation wicri:level="1"><nlm:aff id="A49">University Hospital Gasthuisberg, Division of Gastroenterology, Leuven, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>University Hospital Gasthuisberg, Division of Gastroenterology, Leuven</wicri:regionArea><wicri:noRegion>Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Weersma, Rinse K" sort="Weersma, Rinse K" uniqKey="Weersma R" first="Rinse K." last="Weersma">Rinse K. Weersma</name><affiliation wicri:level="3"><nlm:aff id="A78">University Medical Center Groningen, Department of Gastroenterology, Groningen, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>University Medical Center Groningen, Department of Gastroenterology, Groningen</wicri:regionArea><placeName><settlement type="city">Groningue</settlement><region nuts="2" type="province">Groningue (province)</region></placeName></affiliation></author><author><name sortKey="Rioux, John D" sort="Rioux, John D" uniqKey="Rioux J" first="John D." last="Rioux">John D. Rioux</name><affiliation wicri:level="1"><nlm:aff id="A2">Université de Montréal, Medicine, Montréal, Québec, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Université de Montréal, Medicine, Montréal, Québec</wicri:regionArea><wicri:noRegion>Québec</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A3">Montreal Heart Institute, Research Center, Montréal, Québec, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Montreal Heart Institute, Research Center, Montréal, Québec</wicri:regionArea><wicri:noRegion>Québec</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">21297633</idno><idno type="pmc">3084597</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084597</idno><idno type="RBID">PMC:3084597</idno><idno type="doi">10.1038/ng.764</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">002E05</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002E05</idno><idno type="wicri:Area/Pmc/Curation">002C55</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002C55</idno><idno type="wicri:Area/Pmc/Checkpoint">002244</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002244</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47</title><author><name sortKey="Anderson, Carl A" sort="Anderson, Carl A" uniqKey="Anderson C" first="Carl A." last="Anderson">Carl A. Anderson</name><affiliation wicri:level="1"><nlm:aff id="A1">Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Boucher, Gabrielle" sort="Boucher, Gabrielle" uniqKey="Boucher G" first="Gabrielle" last="Boucher">Gabrielle Boucher</name><affiliation wicri:level="1"><nlm:aff id="A2">Université de Montréal, Medicine, Montréal, Québec, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Université de Montréal, Medicine, Montréal, Québec</wicri:regionArea><wicri:noRegion>Québec</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A3">Montreal Heart Institute, Research Center, Montréal, Québec, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Montreal Heart Institute, Research Center, Montréal, Québec</wicri:regionArea><wicri:noRegion>Québec</wicri:noRegion></affiliation></author><author><name sortKey="Lees, Charlie W" sort="Lees, Charlie W" uniqKey="Lees C" first="Charlie W." last="Lees">Charlie W. Lees</name><affiliation wicri:level="4"><nlm:aff id="A4">University of Edinburgh, Western General Hospital, Gastrointestinal Unit, Molecular Medicine Centre, Edinburgh, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University of Edinburgh, Western General Hospital, Gastrointestinal Unit, Molecular Medicine Centre, Edinburgh</wicri:regionArea><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region><settlement type="city">Édimbourg</settlement></placeName><orgName type="university">Université d'Édimbourg</orgName></affiliation></author><author><name sortKey="Franke, Andre" sort="Franke, Andre" uniqKey="Franke A" first="Andre" last="Franke">Andre Franke</name><affiliation wicri:level="3"><nlm:aff id="A5">Christian-Albrechts-University Kiel, Institute of Clinical Molecular Biology, Kiel, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Christian-Albrechts-University Kiel, Institute of Clinical Molecular Biology, Kiel</wicri:regionArea><placeName><region type="land" nuts="2">Schleswig-Holstein</region><settlement type="city">Kiel</settlement></placeName></affiliation></author><author><name sortKey="D Mato, Mauro" sort="D Mato, Mauro" uniqKey="D Mato M" first="Mauro" last="D Mato">Mauro D Mato</name><affiliation wicri:level="3"><nlm:aff id="A6">Karolinska Institute, Department of Biosciences and Nutrition, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Karolinska Institute, Department of Biosciences and Nutrition, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Taylor, Kent D" sort="Taylor, Kent D" uniqKey="Taylor K" first="Kent D." last="Taylor">Kent D. Taylor</name><affiliation wicri:level="2"><nlm:aff id="A7">Cedars-Sinai Medical Center, Inflammatory Bowel and Immunobiology Research Institute, Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cedars-Sinai Medical Center, Inflammatory Bowel and Immunobiology Research Institute, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Lee, James C" sort="Lee, James C" uniqKey="Lee J" first="James C." last="Lee">James C. Lee</name><affiliation wicri:level="4"><nlm:aff id="A8">Addenbrooke’s Hospital, University of Cambridge, Gastroenterology Research Unit, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Addenbrooke’s Hospital, University of Cambridge, Gastroenterology Research Unit, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Goyette, Philippe" sort="Goyette, Philippe" uniqKey="Goyette P" first="Philippe" last="Goyette">Philippe Goyette</name><affiliation wicri:level="1"><nlm:aff id="A2">Université de Montréal, Medicine, Montréal, Québec, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Université de Montréal, Medicine, Montréal, Québec</wicri:regionArea><wicri:noRegion>Québec</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A3">Montreal Heart Institute, Research Center, Montréal, Québec, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Montreal Heart Institute, Research Center, Montréal, Québec</wicri:regionArea><wicri:noRegion>Québec</wicri:noRegion></affiliation></author><author><name sortKey="Imielinski, Marcin" sort="Imielinski, Marcin" uniqKey="Imielinski M" first="Marcin" last="Imielinski">Marcin Imielinski</name><affiliation wicri:level="2"><nlm:aff id="A9">The Children’s Hospital of Philadelphia, Center for Applied Genomics, Philadelphia, Pennsylvania, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Children’s Hospital of Philadelphia, Center for Applied Genomics, Philadelphia, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Latiano, Anna" sort="Latiano, Anna" uniqKey="Latiano A" first="Anna" last="Latiano">Anna Latiano</name><affiliation wicri:level="1"><nlm:aff id="A10">IRCCS-CSS Hospital, Unit of Gastroenterology, San Giovanni Rotondo, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>IRCCS-CSS Hospital, Unit of Gastroenterology, San Giovanni Rotondo</wicri:regionArea><wicri:noRegion>San Giovanni Rotondo</wicri:noRegion></affiliation></author><author><name sortKey="Lagace, Caroline" sort="Lagace, Caroline" uniqKey="Lagace C" first="Caroline" last="Lagacé">Caroline Lagacé</name><affiliation wicri:level="1"><nlm:aff id="A2">Université de Montréal, Medicine, Montréal, Québec, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Université de Montréal, Medicine, Montréal, Québec</wicri:regionArea><wicri:noRegion>Québec</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A3">Montreal Heart Institute, Research Center, Montréal, Québec, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Montreal Heart Institute, Research Center, Montréal, Québec</wicri:regionArea><wicri:noRegion>Québec</wicri:noRegion></affiliation></author><author><name sortKey="Scott, Regan" sort="Scott, Regan" uniqKey="Scott R" first="Regan" last="Scott">Regan Scott</name><affiliation wicri:level="2"><nlm:aff id="A11">University of Pittsburgh School of Medicine, Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Pittsburgh, Pennsylvania, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Pittsburgh School of Medicine, Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Pittsburgh, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Amininejad, Leila" sort="Amininejad, Leila" uniqKey="Amininejad L" first="Leila" last="Amininejad">Leila Amininejad</name><affiliation wicri:level="3"><nlm:aff id="A12">Erasmus Hospital, Free University of Brussels, Department of Gastroenterology, Brussels, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Erasmus Hospital, Free University of Brussels, Department of Gastroenterology, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation></author><author><name sortKey="Bumpstead, Suzannah" sort="Bumpstead, Suzannah" uniqKey="Bumpstead S" first="Suzannah" last="Bumpstead">Suzannah Bumpstead</name><affiliation wicri:level="1"><nlm:aff id="A1">Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Baidoo, Leonard" sort="Baidoo, Leonard" uniqKey="Baidoo L" first="Leonard" last="Baidoo">Leonard Baidoo</name><affiliation wicri:level="2"><nlm:aff id="A11">University of Pittsburgh School of Medicine, Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Pittsburgh, Pennsylvania, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Pittsburgh School of Medicine, Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Pittsburgh, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Baldassano, Robert N" sort="Baldassano, Robert N" uniqKey="Baldassano R" first="Robert N." last="Baldassano">Robert N. Baldassano</name><affiliation wicri:level="2"><nlm:aff id="A13">The Children’s Hospital of Philadelphia, Department of Pediatrics, Center for Pediatric Inflammatory Bowel Disease, Philadelphia, Pennsylvania, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Children’s Hospital of Philadelphia, Department of Pediatrics, Center for Pediatric Inflammatory Bowel Disease, Philadelphia, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Barclay, Murray" sort="Barclay, Murray" uniqKey="Barclay M" first="Murray" last="Barclay">Murray Barclay</name><affiliation wicri:level="1"><nlm:aff id="A14">University of Otago, Department of Medicine, Christchurch, New Zealand</nlm:aff><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea>University of Otago, Department of Medicine, Christchurch</wicri:regionArea><wicri:noRegion>Christchurch</wicri:noRegion></affiliation></author><author><name sortKey="Bayless, Theodore M" sort="Bayless, Theodore M" uniqKey="Bayless T" first="Theodore M." last="Bayless">Theodore M. Bayless</name><affiliation wicri:level="2"><nlm:aff id="A15">Johns Hopkins University School of Medicine, Meyeroff Inflammatory Bowel Disease Center, Dept. of Medicine, Baltimore, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Johns Hopkins University School of Medicine, Meyeroff Inflammatory Bowel Disease Center, Dept. of Medicine, Baltimore, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Brand, Stephan" sort="Brand, Stephan" uniqKey="Brand S" first="Stephan" last="Brand">Stephan Brand</name><affiliation wicri:level="3"><nlm:aff id="A16">University Hospital Munich, Department of Medicine II, Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Hospital Munich, Department of Medicine II, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Buning, Carsten" sort="Buning, Carsten" uniqKey="Buning C" first="Carsten" last="Büning">Carsten Büning</name><affiliation wicri:level="3"><nlm:aff id="A17">Universitätsmedizin Berlin, Department of Gastroenterology, Charité, Campus Mitte, Berlin, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Universitätsmedizin Berlin, Department of Gastroenterology, Charité, Campus Mitte, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Colombel, Jean Frederic" sort="Colombel, Jean Frederic" uniqKey="Colombel J" first="Jean-Frédéric" last="Colombel">Jean-Frédéric Colombel</name><affiliation wicri:level="3"><nlm:aff id="A18">Université de Lille Department of Hepato-Gastroenterology, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université de Lille Department of Hepato-Gastroenterology, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Denson, Lee A" sort="Denson, Lee A" uniqKey="Denson L" first="Lee A." last="Denson">Lee A. Denson</name><affiliation wicri:level="2"><nlm:aff id="A19">Cincinnati Children’s Hospital Medical Center, Pediatric Gastroenterology, Cincinnati, Ohio, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cincinnati Children’s Hospital Medical Center, Pediatric Gastroenterology, Cincinnati, Ohio</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="De Vos, Martine" sort="De Vos, Martine" uniqKey="De Vos M" first="Martine" last="De Vos">Martine De Vos</name><affiliation wicri:level="1"><nlm:aff id="A20">Ghent University Hospital, Department of Hepatology and Gastroenterology, Ghent, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Ghent University Hospital, Department of Hepatology and Gastroenterology, Ghent</wicri:regionArea><wicri:noRegion>Ghent</wicri:noRegion></affiliation></author><author><name sortKey="Dubinsky, Marla" sort="Dubinsky, Marla" uniqKey="Dubinsky M" first="Marla" last="Dubinsky">Marla Dubinsky</name><affiliation wicri:level="2"><nlm:aff id="A21">Cedars-Sinai Medical Center, Department of Pediatrics, Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cedars-Sinai Medical Center, Department of Pediatrics, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Edwards, Cathryn" sort="Edwards, Cathryn" uniqKey="Edwards C" first="Cathryn" last="Edwards">Cathryn Edwards</name><affiliation wicri:level="1"><nlm:aff id="A22">Torbay Hospital, Department of Gastroenterology, Torbay, Devon, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Torbay Hospital, Department of Gastroenterology, Torbay, Devon</wicri:regionArea><wicri:noRegion>Devon</wicri:noRegion></affiliation></author><author><name sortKey="Ellinghaus, David" sort="Ellinghaus, David" uniqKey="Ellinghaus D" first="David" last="Ellinghaus">David Ellinghaus</name><affiliation wicri:level="3"><nlm:aff id="A5">Christian-Albrechts-University Kiel, Institute of Clinical Molecular Biology, Kiel, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Christian-Albrechts-University Kiel, Institute of Clinical Molecular Biology, Kiel</wicri:regionArea><placeName><region type="land" nuts="2">Schleswig-Holstein</region><settlement type="city">Kiel</settlement></placeName></affiliation></author><author><name sortKey="Fehrmann, Rudolf S N" sort="Fehrmann, Rudolf S N" uniqKey="Fehrmann R" first="Rudolf S. N." last="Fehrmann">Rudolf S. N. Fehrmann</name><affiliation wicri:level="3"><nlm:aff id="A23">University Medical Center Groningen, Department of Genetics, Groningen, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>University Medical Center Groningen, Department of Genetics, Groningen</wicri:regionArea><placeName><settlement type="city">Groningue</settlement><region nuts="2" type="province">Groningue (province)</region></placeName></affiliation></author><author><name sortKey="Floyd, James A B" sort="Floyd, James A B" uniqKey="Floyd J" first="James A. B." last="Floyd">James A. B. Floyd</name><affiliation wicri:level="1"><nlm:aff id="A1">Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Florin, Tim" sort="Florin, Tim" uniqKey="Florin T" first="Tim" last="Florin">Tim Florin</name><affiliation wicri:level="1"><nlm:aff id="A24">Mater Health Services, Department of Gastroenterology, Brisbane, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Mater Health Services, Department of Gastroenterology, Brisbane</wicri:regionArea><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Franchimont, Denis" sort="Franchimont, Denis" uniqKey="Franchimont D" first="Denis" last="Franchimont">Denis Franchimont</name><affiliation wicri:level="3"><nlm:aff id="A25">Erasmus Hospital, Free University of Brussels, Department of Gastroenterology, Brussels, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Erasmus Hospital, Free University of Brussels, Department of Gastroenterology, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation></author><author><name sortKey="Franke, Lude" sort="Franke, Lude" uniqKey="Franke L" first="Lude" last="Franke">Lude Franke</name><affiliation wicri:level="3"><nlm:aff id="A23">University Medical Center Groningen, Department of Genetics, Groningen, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>University Medical Center Groningen, Department of Genetics, Groningen</wicri:regionArea><placeName><settlement type="city">Groningue</settlement><region nuts="2" type="province">Groningue (province)</region></placeName></affiliation></author><author><name sortKey="Georges, Michel" sort="Georges, Michel" uniqKey="Georges M" first="Michel" last="Georges">Michel Georges</name><affiliation wicri:level="4"><nlm:aff id="A26">University of Liège, Department of Genetics, Faculty of Veterinary Medicine, Liège, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>University of Liège, Department of Genetics, Faculty of Veterinary Medicine, Liège</wicri:regionArea><orgName type="university">Université de Liège</orgName><placeName><settlement type="city">Liège</settlement><region type="region" nuts="1">Région wallonne</region><region type="province" nuts="1">Province de Liège</region></placeName></affiliation></author><author><name sortKey="Glas, Jurgen" sort="Glas, Jurgen" uniqKey="Glas J" first="Jürgen" last="Glas">Jürgen Glas</name><affiliation wicri:level="3"><nlm:aff id="A16">University Hospital Munich, Department of Medicine II, Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Hospital Munich, Department of Medicine II, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Glazer, Nicole L" sort="Glazer, Nicole L" uniqKey="Glazer N" first="Nicole L." last="Glazer">Nicole L. Glazer</name><affiliation wicri:level="4"><nlm:aff id="A27">University of Washington, Cardiovascular Health Research Unit, Department of Internal Medicine, Seattle, Washington, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Washington, Cardiovascular Health Research Unit, Department of Internal Medicine, Seattle, Washington</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Guthery, Stephen L" sort="Guthery, Stephen L" uniqKey="Guthery S" first="Stephen L." last="Guthery">Stephen L. Guthery</name><affiliation wicri:level="2"><nlm:aff id="A28">University of Utah School of Medicine, Department of Pediatrics, Salt Lake City, Utah, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Utah School of Medicine, Department of Pediatrics, Salt Lake City, Utah</wicri:regionArea><placeName><region type="state">Utah</region></placeName></affiliation></author><author><name sortKey="Haritunians, Talin" sort="Haritunians, Talin" uniqKey="Haritunians T" first="Talin" last="Haritunians">Talin Haritunians</name><affiliation wicri:level="2"><nlm:aff id="A29">Cedars-Sinai Medical Center, Medical Genetics Institute, Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cedars-Sinai Medical Center, Medical Genetics Institute, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Hayward, Nicholas K" sort="Hayward, Nicholas K" uniqKey="Hayward N" first="Nicholas K." last="Hayward">Nicholas K. Hayward</name><affiliation wicri:level="1"><nlm:aff id="A30">Queensland Institute of Medical Research, Genetic Epidemiology, Brisbane, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research, Genetic Epidemiology, Brisbane</wicri:regionArea><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Hugot, Jean Pierre" sort="Hugot, Jean Pierre" uniqKey="Hugot J" first="Jean-Pierre" last="Hugot">Jean-Pierre Hugot</name><affiliation wicri:level="3"><nlm:aff id="A31">Université Paris Diderot & INSERM & Hopital Robert Debre APHP, Gastroenterology, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Paris Diderot & INSERM & Hopital Robert Debre APHP, Gastroenterology, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Jobin, Gilles" sort="Jobin, Gilles" uniqKey="Jobin G" first="Gilles" last="Jobin">Gilles Jobin</name><affiliation wicri:level="1"><nlm:aff id="A2">Université de Montréal, Medicine, Montréal, Québec, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Université de Montréal, Medicine, Montréal, Québec</wicri:regionArea><wicri:noRegion>Québec</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A32">Hôpital Maisonneuve-Rosemont, Dept of Gastroenterology, Montréal, Québec, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Hôpital Maisonneuve-Rosemont, Dept of Gastroenterology, Montréal, Québec</wicri:regionArea><wicri:noRegion>Québec</wicri:noRegion></affiliation></author><author><name sortKey="Laukens, Debby" sort="Laukens, Debby" uniqKey="Laukens D" first="Debby" last="Laukens">Debby Laukens</name><affiliation wicri:level="1"><nlm:aff id="A20">Ghent University Hospital, Department of Hepatology and Gastroenterology, Ghent, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Ghent University Hospital, Department of Hepatology and Gastroenterology, Ghent</wicri:regionArea><wicri:noRegion>Ghent</wicri:noRegion></affiliation></author><author><name sortKey="Lawrance, Ian" sort="Lawrance, Ian" uniqKey="Lawrance I" first="Ian" last="Lawrance">Ian Lawrance</name><affiliation wicri:level="1"><nlm:aff id="A33">The University of Western Australia, School of Medicine and Pharmacology, Fremantle, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>The University of Western Australia, School of Medicine and Pharmacology, Fremantle</wicri:regionArea><wicri:noRegion>Fremantle</wicri:noRegion></affiliation></author><author><name sortKey="Lemann, Marc" sort="Lemann, Marc" uniqKey="Lemann M" first="Marc" last="Lémann">Marc Lémann</name><affiliation wicri:level="3"><nlm:aff id="A34">Université Paris Diderot, GETAID group, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Paris Diderot, GETAID group, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Levine, Arie" sort="Levine, Arie" uniqKey="Levine A" first="Arie" last="Levine">Arie Levine</name><affiliation wicri:level="1"><nlm:aff id="A35">Tel Aviv University, Pediatric Gastroenterology Unit, Wolfson Medical Center and Sackler School of Medicine, Tel Aviv, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Tel Aviv University, Pediatric Gastroenterology Unit, Wolfson Medical Center and Sackler School of Medicine, Tel Aviv</wicri:regionArea><wicri:noRegion>Tel Aviv</wicri:noRegion></affiliation></author><author><name sortKey="Libioulle, Cecile" sort="Libioulle, Cecile" uniqKey="Libioulle C" first="Cecile" last="Libioulle">Cecile Libioulle</name><affiliation wicri:level="1"><nlm:aff id="A36">Centre Hospitalier Universitaire Université de Liège, Division of Gastroenterology, Liège, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Centre Hospitalier Universitaire Université de Liège, Division of Gastroenterology, Liège</wicri:regionArea><wicri:noRegion>Liège</wicri:noRegion></affiliation></author><author><name sortKey="Louis, Edouard" sort="Louis, Edouard" uniqKey="Louis E" first="Edouard" last="Louis">Edouard Louis</name><affiliation wicri:level="1"><nlm:aff id="A36">Centre Hospitalier Universitaire Université de Liège, Division of Gastroenterology, Liège, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Centre Hospitalier Universitaire Université de Liège, Division of Gastroenterology, Liège</wicri:regionArea><wicri:noRegion>Liège</wicri:noRegion></affiliation></author><author><name sortKey="Mcgovern, Dermot P" sort="Mcgovern, Dermot P" uniqKey="Mcgovern D" first="Dermot P." last="Mcgovern">Dermot P. Mcgovern</name><affiliation wicri:level="2"><nlm:aff id="A7">Cedars-Sinai Medical Center, Inflammatory Bowel and Immunobiology Research Institute, Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cedars-Sinai Medical Center, Inflammatory Bowel and Immunobiology Research Institute, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A29">Cedars-Sinai Medical Center, Medical Genetics Institute, Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cedars-Sinai Medical Center, Medical Genetics Institute, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Milla, Monica" sort="Milla, Monica" uniqKey="Milla M" first="Monica" last="Milla">Monica Milla</name><affiliation wicri:level="1"><nlm:aff id="A37">AOU Careggi, Unit of Gastroenterology SOD2, Florence, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>AOU Careggi, Unit of Gastroenterology SOD2, Florence</wicri:regionArea><wicri:noRegion>Florence</wicri:noRegion></affiliation></author><author><name sortKey="Montgomery, Grant W" sort="Montgomery, Grant W" uniqKey="Montgomery G" first="Grant W." last="Montgomery">Grant W. Montgomery</name><affiliation wicri:level="1"><nlm:aff id="A30">Queensland Institute of Medical Research, Genetic Epidemiology, Brisbane, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research, Genetic Epidemiology, Brisbane</wicri:regionArea><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Morley, Katherine I" sort="Morley, Katherine I" uniqKey="Morley K" first="Katherine I." last="Morley">Katherine I. Morley</name><affiliation wicri:level="1"><nlm:aff id="A1">Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Mowat, Craig" sort="Mowat, Craig" uniqKey="Mowat C" first="Craig" last="Mowat">Craig Mowat</name><affiliation wicri:level="1"><nlm:aff id="A38">Ninewells Hospital and Medical School, Dept of Medicine, Dundee, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Ninewells Hospital and Medical School, Dept of Medicine, Dundee</wicri:regionArea><wicri:noRegion>Dundee</wicri:noRegion></affiliation></author><author><name sortKey="Ng, Aylwin" sort="Ng, Aylwin" uniqKey="Ng A" first="Aylwin" last="Ng">Aylwin Ng</name><affiliation wicri:level="2"><nlm:aff id="A39">Massachusetts General Hospital, Harvard Medical School, Gastroenterology Unit Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Massachusetts General Hospital, Harvard Medical School, Gastroenterology Unit Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A40">Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Newman, William" sort="Newman, William" uniqKey="Newman W" first="William" last="Newman">William Newman</name><affiliation wicri:level="3"><nlm:aff id="A41">University of Manchester Department of Medical Genetics, Manchester, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University of Manchester Department of Medical Genetics, Manchester</wicri:regionArea><placeName><settlement type="city">Manchester</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Manchester</region></placeName></affiliation></author><author><name sortKey="Ophoff, Roel A" sort="Ophoff, Roel A" uniqKey="Ophoff R" first="Roel A" last="Ophoff">Roel A. Ophoff</name><affiliation wicri:level="3"><nlm:aff id="A42">University Medical Center Utrecht, Department of Medical Genetics, Utrecht, Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>University Medical Center Utrecht, Department of Medical Genetics, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Papi, Laura" sort="Papi, Laura" uniqKey="Papi L" first="Laura" last="Papi">Laura Papi</name><affiliation wicri:level="1"><nlm:aff id="A43">University of Florence, Institute of Human Genetics, Florence, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>University of Florence, Institute of Human Genetics, Florence</wicri:regionArea><wicri:noRegion>Florence</wicri:noRegion></affiliation></author><author><name sortKey="Palmieri, Orazio" sort="Palmieri, Orazio" uniqKey="Palmieri O" first="Orazio" last="Palmieri">Orazio Palmieri</name><affiliation wicri:level="1"><nlm:aff id="A10">IRCCS-CSS Hospital, Unit of Gastroenterology, San Giovanni Rotondo, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>IRCCS-CSS Hospital, Unit of Gastroenterology, San Giovanni Rotondo</wicri:regionArea><wicri:noRegion>San Giovanni Rotondo</wicri:noRegion></affiliation></author><author><name sortKey="Peyrin Biroulet, Laurent" sort="Peyrin Biroulet, Laurent" uniqKey="Peyrin Biroulet L" first="Laurent" last="Peyrin-Biroulet">Laurent Peyrin-Biroulet</name><affiliation wicri:level="3"><nlm:aff id="A44">University Hospital of Nancy, Department of Hepato-Gastroenterology, Vandoeuvre-lès-Nancy, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>University Hospital of Nancy, Department of Hepato-Gastroenterology, Vandoeuvre-lès-Nancy</wicri:regionArea><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Lorraine (région)</region><settlement type="city">Vandœuvre-lès-Nancy</settlement><settlement type="city" wicri:auto="agglo">Nancy</settlement></placeName></affiliation></author><author><name sortKey="Panes, Julian" sort="Panes, Julian" uniqKey="Panes J" first="Julián" last="Panés">Julián Panés</name><affiliation wicri:level="3"><nlm:aff id="A45">Hospital Clínic de Barcelona, IDIBAPS, CIBERehd, Department of Gastroenterology, Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital Clínic de Barcelona, IDIBAPS, CIBERehd, Department of Gastroenterology, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Phillips, Anne" sort="Phillips, Anne" uniqKey="Phillips A" first="Anne" last="Phillips">Anne Phillips</name><affiliation wicri:level="1"><nlm:aff id="A38">Ninewells Hospital and Medical School, Dept of Medicine, Dundee, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Ninewells Hospital and Medical School, Dept of Medicine, Dundee</wicri:regionArea><wicri:noRegion>Dundee</wicri:noRegion></affiliation></author><author><name sortKey="Prescott, Natalie J" sort="Prescott, Natalie J" uniqKey="Prescott N" first="Natalie J." last="Prescott">Natalie J. Prescott</name><affiliation wicri:level="3"><nlm:aff id="A46">King’s College London School of Medicine, Guy’s Hospital, Department of Medical and Molecular Genetics, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>King’s College London School of Medicine, Guy’s Hospital, Department of Medical and Molecular Genetics, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Proctor, Deborah D" sort="Proctor, Deborah D" uniqKey="Proctor D" first="Deborah D." last="Proctor">Deborah D. Proctor</name><affiliation wicri:level="2"><nlm:aff id="A47">Yale University, Section of Digestive Diseases, Department of Medicine, New Haven, Connecticut, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Yale University, Section of Digestive Diseases, Department of Medicine, New Haven, Connecticut</wicri:regionArea><placeName><region type="state">Connecticut</region></placeName></affiliation></author><author><name sortKey="Roberts, Rebecca" sort="Roberts, Rebecca" uniqKey="Roberts R" first="Rebecca" last="Roberts">Rebecca Roberts</name><affiliation wicri:level="1"><nlm:aff id="A14">University of Otago, Department of Medicine, Christchurch, New Zealand</nlm:aff><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea>University of Otago, Department of Medicine, Christchurch</wicri:regionArea><wicri:noRegion>Christchurch</wicri:noRegion></affiliation></author><author><name sortKey="Russell, Richard" sort="Russell, Richard" uniqKey="Russell R" first="Richard" last="Russell">Richard Russell</name><affiliation wicri:level="1"><nlm:aff id="A48">Royal Hospital for Sick Children, Paediatric Gastroenterology and Nutrition, Glasgow, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Royal Hospital for Sick Children, Paediatric Gastroenterology and Nutrition, Glasgow</wicri:regionArea><wicri:noRegion>Glasgow</wicri:noRegion></affiliation></author><author><name sortKey="Rutgeerts, Paul" sort="Rutgeerts, Paul" uniqKey="Rutgeerts P" first="Paul" last="Rutgeerts">Paul Rutgeerts</name><affiliation wicri:level="1"><nlm:aff id="A49">University Hospital Gasthuisberg, Division of Gastroenterology, Leuven, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>University Hospital Gasthuisberg, Division of Gastroenterology, Leuven</wicri:regionArea><wicri:noRegion>Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Sanderson, Jeremy" sort="Sanderson, Jeremy" uniqKey="Sanderson J" first="Jeremy" last="Sanderson">Jeremy Sanderson</name><affiliation wicri:level="3"><nlm:aff id="A50">Guy’s & St Thomas’ NHS Foundation Trust, St Thomas’ Hospital, Dept Gastroenterology, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Guy’s & St Thomas’ NHS Foundation Trust, St Thomas’ Hospital, Dept Gastroenterology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Sans, Miquel" sort="Sans, Miquel" uniqKey="Sans M" first="Miquel" last="Sans">Miquel Sans</name><affiliation wicri:level="3"><nlm:aff id="A51">Hospital Clínic de Barcelona, IDIBAPS, CIBERehd, Department of Gastroenterology, Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital Clínic de Barcelona, IDIBAPS, CIBERehd, Department of Gastroenterology, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Schumm, Philip" sort="Schumm, Philip" uniqKey="Schumm P" first="Philip" last="Schumm">Philip Schumm</name><affiliation wicri:level="2"><nlm:aff id="A52">University of Chicago, Department of Health Studies, Chicago, Illinois, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Chicago, Department of Health Studies, Chicago, Illinois</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Seibold, Frank" sort="Seibold, Frank" uniqKey="Seibold F" first="Frank" last="Seibold">Frank Seibold</name><affiliation wicri:level="4"><nlm:aff id="A53">University of Bern, Division of Gastroenterology, Inselspital, Bern, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>University of Bern, Division of Gastroenterology, Inselspital, Bern</wicri:regionArea><placeName><settlement type="city">Berne</settlement><region type="région" nuts="3">Canton de Berne</region><settlement type="city">Berne</settlement></placeName><orgName type="university">Université de Berne</orgName></affiliation></author><author><name sortKey="Sharma, Yashoda" sort="Sharma, Yashoda" uniqKey="Sharma Y" first="Yashoda" last="Sharma">Yashoda Sharma</name><affiliation wicri:level="2"><nlm:aff id="A47">Yale University, Section of Digestive Diseases, Department of Medicine, New Haven, Connecticut, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Yale University, Section of Digestive Diseases, Department of Medicine, New Haven, Connecticut</wicri:regionArea><placeName><region type="state">Connecticut</region></placeName></affiliation></author><author><name sortKey="Simms, Lisa" sort="Simms, Lisa" uniqKey="Simms L" first="Lisa" last="Simms">Lisa Simms</name><affiliation wicri:level="1"><nlm:aff id="A30">Queensland Institute of Medical Research, Genetic Epidemiology, Brisbane, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research, Genetic Epidemiology, Brisbane</wicri:regionArea><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Seielstad, Mark" sort="Seielstad, Mark" uniqKey="Seielstad M" first="Mark" last="Seielstad">Mark Seielstad</name><affiliation wicri:level="1"><nlm:aff id="A54">Genome Institute of Singapore, Human Genetics, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Genome Institute of Singapore, Human Genetics</wicri:regionArea><wicri:noRegion>Human Genetics</wicri:noRegion></affiliation><affiliation wicri:level="2"><nlm:aff id="A55">Institute for Human Genetics, University of California San Fransisco, San Francisco, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institute for Human Genetics, University of California San Fransisco, San Francisco, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Steinhart, A Hillary" sort="Steinhart, A Hillary" uniqKey="Steinhart A" first="A. Hillary" last="Steinhart">A. Hillary Steinhart</name><affiliation wicri:level="4"><nlm:aff id="A56">University of Toronto, Mount Sinai Hospital Inflammatory Bowel Disease Centre, Toronto, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>University of Toronto, Mount Sinai Hospital Inflammatory Bowel Disease Centre, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Targan, Stephan R" sort="Targan, Stephan R" uniqKey="Targan S" first="Stephan R." last="Targan">Stephan R. Targan</name><affiliation wicri:level="2"><nlm:aff id="A7">Cedars-Sinai Medical Center, Inflammatory Bowel and Immunobiology Research Institute, Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cedars-Sinai Medical Center, Inflammatory Bowel and Immunobiology Research Institute, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Van Den Berg, Leonard H" sort="Van Den Berg, Leonard H" uniqKey="Van Den Berg L" first="Leonard H." last="Van Den Berg">Leonard H. Van Den Berg</name><affiliation wicri:level="3"><nlm:aff id="A57">Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Department of Neurology, Utrecht, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Department of Neurology, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Vatn, Morten" sort="Vatn, Morten" uniqKey="Vatn M" first="Morten" last="Vatn">Morten Vatn</name><affiliation wicri:level="3"><nlm:aff id="A58">Rikshospitalet University Hospital, Medical Department, Oslo, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea>Rikshospitalet University Hospital, Medical Department, Oslo</wicri:regionArea><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation></author><author><name sortKey="Verspaget, Hein" sort="Verspaget, Hein" uniqKey="Verspaget H" first="Hein" last="Verspaget">Hein Verspaget</name><affiliation wicri:level="3"><nlm:aff id="A59">Leiden University Medical Center, Experimental Gastroenterology, Leiden, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Leiden University Medical Center, Experimental Gastroenterology, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Walters, Thomas" sort="Walters, Thomas" uniqKey="Walters T" first="Thomas" last="Walters">Thomas Walters</name><affiliation wicri:level="4"><nlm:aff id="A60">The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>The Hospital for Sick Children, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Wijmenga, Cisca" sort="Wijmenga, Cisca" uniqKey="Wijmenga C" first="Cisca" last="Wijmenga">Cisca Wijmenga</name><affiliation wicri:level="3"><nlm:aff id="A23">University Medical Center Groningen, Department of Genetics, Groningen, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>University Medical Center Groningen, Department of Genetics, Groningen</wicri:regionArea><placeName><settlement type="city">Groningue</settlement><region nuts="2" type="province">Groningue (province)</region></placeName></affiliation></author><author><name sortKey="Wilson, David C" sort="Wilson, David C" uniqKey="Wilson D" first="David C." last="Wilson">David C. Wilson</name><affiliation wicri:level="1"><nlm:aff id="A48">Royal Hospital for Sick Children, Paediatric Gastroenterology and Nutrition, Glasgow, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Royal Hospital for Sick Children, Paediatric Gastroenterology and Nutrition, Glasgow</wicri:regionArea><wicri:noRegion>Glasgow</wicri:noRegion></affiliation><affiliation wicri:level="2"><nlm:aff id="A61">Child Life and Health, University of Edinburgh, Scotland</nlm:aff><country>Royaume-Uni</country><placeName><region type="country">Écosse</region></placeName><wicri:cityArea>Child Life and Health, University of Edinburgh</wicri:cityArea></affiliation></author><author><name sortKey="Westra, Harm Jan" sort="Westra, Harm Jan" uniqKey="Westra H" first="Harm-Jan" last="Westra">Harm-Jan Westra</name><affiliation wicri:level="3"><nlm:aff id="A23">University Medical Center Groningen, Department of Genetics, Groningen, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>University Medical Center Groningen, Department of Genetics, Groningen</wicri:regionArea><placeName><settlement type="city">Groningue</settlement><region nuts="2" type="province">Groningue (province)</region></placeName></affiliation></author><author><name sortKey="Xavier, Ramnik J" sort="Xavier, Ramnik J" uniqKey="Xavier R" first="Ramnik J." last="Xavier">Ramnik J. Xavier</name><affiliation wicri:level="2"><nlm:aff id="A39">Massachusetts General Hospital, Harvard Medical School, Gastroenterology Unit Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Massachusetts General Hospital, Harvard Medical School, Gastroenterology Unit Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A40">Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Zhao, Zhen Z" sort="Zhao, Zhen Z" uniqKey="Zhao Z" first="Zhen Z." last="Zhao">Zhen Z. Zhao</name><affiliation wicri:level="1"><nlm:aff id="A30">Queensland Institute of Medical Research, Genetic Epidemiology, Brisbane, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research, Genetic Epidemiology, Brisbane</wicri:regionArea><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Ponsioen, Cyriel Y" sort="Ponsioen, Cyriel Y" uniqKey="Ponsioen C" first="Cyriel Y." last="Ponsioen">Cyriel Y. Ponsioen</name><affiliation wicri:level="3"><nlm:aff id="A62">Academic Medical Center, Department of Gastroenterology, Amsterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Academic Medical Center, Department of Gastroenterology, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Andersen, Vibeke" sort="Andersen, Vibeke" uniqKey="Andersen V" first="Vibeke" last="Andersen">Vibeke Andersen</name><affiliation wicri:level="1"><nlm:aff id="A63">Viborg Regional Hospital, Medical Department, Viborg, Denmark</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Viborg Regional Hospital, Medical Department, Viborg</wicri:regionArea><wicri:noRegion>Viborg</wicri:noRegion></affiliation></author><author><name sortKey="Torkvist, Leif" sort="Torkvist, Leif" uniqKey="Torkvist L" first="Leif" last="Torkvist">Leif Torkvist</name><affiliation wicri:level="3"><nlm:aff id="A64">Karolinska Institutet, Department of Clinical Science Intervention and Technology, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Karolinska Institutet, Department of Clinical Science Intervention and Technology, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Gazouli, Maria" sort="Gazouli, Maria" uniqKey="Gazouli M" first="Maria" last="Gazouli">Maria Gazouli</name><affiliation wicri:level="3"><nlm:aff id="A65">University of Athens, Department of Biology, School of Medicine, Athens, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>University of Athens, Department of Biology, School of Medicine, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Anagnou, Nicholas P" sort="Anagnou, Nicholas P" uniqKey="Anagnou N" first="Nicholas P." last="Anagnou">Nicholas P. Anagnou</name><affiliation wicri:level="3"><nlm:aff id="A65">University of Athens, Department of Biology, School of Medicine, Athens, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>University of Athens, Department of Biology, School of Medicine, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Karlsen, Tom H" sort="Karlsen, Tom H" uniqKey="Karlsen T" first="Tom H." last="Karlsen">Tom H. Karlsen</name><affiliation wicri:level="3"><nlm:aff id="A58">Rikshospitalet University Hospital, Medical Department, Oslo, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea>Rikshospitalet University Hospital, Medical Department, Oslo</wicri:regionArea><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation></author><author><name sortKey="Kupcinskas, Limas" sort="Kupcinskas, Limas" uniqKey="Kupcinskas L" first="Limas" last="Kupcinskas">Limas Kupcinskas</name><affiliation wicri:level="1"><nlm:aff id="A66">Kaunas University of medicine, Department of Gastroenterology, Kaunas, Lithuania</nlm:aff><country xml:lang="fr">Lituanie</country><wicri:regionArea>Kaunas University of medicine, Department of Gastroenterology, Kaunas</wicri:regionArea><wicri:noRegion>Kaunas</wicri:noRegion></affiliation></author><author><name sortKey="Sventoraityte, Jurgita" sort="Sventoraityte, Jurgita" uniqKey="Sventoraityte J" first="Jurgita" last="Sventoraityte">Jurgita Sventoraityte</name><affiliation wicri:level="1"><nlm:aff id="A66">Kaunas University of medicine, Department of Gastroenterology, Kaunas, Lithuania</nlm:aff><country xml:lang="fr">Lituanie</country><wicri:regionArea>Kaunas University of medicine, Department of Gastroenterology, Kaunas</wicri:regionArea><wicri:noRegion>Kaunas</wicri:noRegion></affiliation></author><author><name sortKey="Mansfield, John C" sort="Mansfield, John C" uniqKey="Mansfield J" first="John C." last="Mansfield">John C. Mansfield</name><affiliation wicri:level="1"><nlm:aff id="A67">Newcastle University, Institute of Human Genetics, Newcastle upon Tyne, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Newcastle University, Institute of Human Genetics, Newcastle upon Tyne</wicri:regionArea><wicri:noRegion>Newcastle upon Tyne</wicri:noRegion></affiliation></author><author><name sortKey="Kugathasan, Subra" sort="Kugathasan, Subra" uniqKey="Kugathasan S" first="Subra" last="Kugathasan">Subra Kugathasan</name><affiliation wicri:level="2"><nlm:aff id="A68">Emory School of Medicine, Department of Genetics and Department of Pediatrics, Atlanta, Georgia, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Emory School of Medicine, Department of Genetics and Department of Pediatrics, Atlanta, Georgia</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Silverberg, Mark S" sort="Silverberg, Mark S" uniqKey="Silverberg M" first="Mark S." last="Silverberg">Mark S. Silverberg</name><affiliation wicri:level="4"><nlm:aff id="A56">University of Toronto, Mount Sinai Hospital Inflammatory Bowel Disease Centre, Toronto, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>University of Toronto, Mount Sinai Hospital Inflammatory Bowel Disease Centre, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Halfvarson, Jonas" sort="Halfvarson, Jonas" uniqKey="Halfvarson J" first="Jonas" last="Halfvarson">Jonas Halfvarson</name><affiliation wicri:level="1"><nlm:aff id="A69">Örebro University Hospital, Department of Medicine, Örebro, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Örebro University Hospital, Department of Medicine, Örebro</wicri:regionArea><wicri:noRegion>Örebro</wicri:noRegion></affiliation></author><author><name sortKey="Rotter, Jerome I" sort="Rotter, Jerome I" uniqKey="Rotter J" first="Jerome I." last="Rotter">Jerome I. Rotter</name><affiliation wicri:level="2"><nlm:aff id="A29">Cedars-Sinai Medical Center, Medical Genetics Institute, Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cedars-Sinai Medical Center, Medical Genetics Institute, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Mathew, Christopher G" sort="Mathew, Christopher G" uniqKey="Mathew C" first="Christopher G." last="Mathew">Christopher G. Mathew</name><affiliation wicri:level="3"><nlm:aff id="A46">King’s College London School of Medicine, Guy’s Hospital, Department of Medical and Molecular Genetics, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>King’s College London School of Medicine, Guy’s Hospital, Department of Medical and Molecular Genetics, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Griffiths, Anne M" sort="Griffiths, Anne M" uniqKey="Griffiths A" first="Anne M." last="Griffiths">Anne M. Griffiths</name><affiliation wicri:level="4"><nlm:aff id="A60">The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>The Hospital for Sick Children, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Gearry, Richard" sort="Gearry, Richard" uniqKey="Gearry R" first="Richard" last="Gearry">Richard Gearry</name><affiliation wicri:level="1"><nlm:aff id="A14">University of Otago, Department of Medicine, Christchurch, New Zealand</nlm:aff><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea>University of Otago, Department of Medicine, Christchurch</wicri:regionArea><wicri:noRegion>Christchurch</wicri:noRegion></affiliation></author><author><name sortKey="Ahmad, Tariq" sort="Ahmad, Tariq" uniqKey="Ahmad T" first="Tariq" last="Ahmad">Tariq Ahmad</name><affiliation wicri:level="1"><nlm:aff id="A70">Peninsula College of Medicine and Dentistry, Barrack Road, Exeter, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Peninsula College of Medicine and Dentistry, Barrack Road, Exeter</wicri:regionArea><wicri:noRegion>Exeter</wicri:noRegion></affiliation></author><author><name sortKey="Brant, Steven R" sort="Brant, Steven R" uniqKey="Brant S" first="Steven R." last="Brant">Steven R. Brant</name><affiliation wicri:level="2"><nlm:aff id="A15">Johns Hopkins University School of Medicine, Meyeroff Inflammatory Bowel Disease Center, Dept. of Medicine, Baltimore, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Johns Hopkins University School of Medicine, Meyeroff Inflammatory Bowel Disease Center, Dept. of Medicine, Baltimore, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Chamaillard, Mathias" sort="Chamaillard, Mathias" uniqKey="Chamaillard M" first="Mathias" last="Chamaillard">Mathias Chamaillard</name><affiliation wicri:level="3"><nlm:aff id="A71">Inserm, U1019, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm, U1019, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Satsangi, Jack" sort="Satsangi, Jack" uniqKey="Satsangi J" first="Jack" last="Satsangi">Jack Satsangi</name><affiliation wicri:level="4"><nlm:aff id="A4">University of Edinburgh, Western General Hospital, Gastrointestinal Unit, Molecular Medicine Centre, Edinburgh, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University of Edinburgh, Western General Hospital, Gastrointestinal Unit, Molecular Medicine Centre, Edinburgh</wicri:regionArea><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region><settlement type="city">Édimbourg</settlement></placeName><orgName type="university">Université d'Édimbourg</orgName></affiliation></author><author><name sortKey="Cho, Judy H" sort="Cho, Judy H" uniqKey="Cho J" first="Judy H." last="Cho">Judy H. Cho</name><affiliation wicri:level="2"><nlm:aff id="A47">Yale University, Section of Digestive Diseases, Department of Medicine, New Haven, Connecticut, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Yale University, Section of Digestive Diseases, Department of Medicine, New Haven, Connecticut</wicri:regionArea><placeName><region type="state">Connecticut</region></placeName></affiliation><affiliation><nlm:aff id="A72">Yale University, Department of Genetics, Yale School of Medicine, New Haven CT</nlm:aff><wicri:noCountry code="subfield">New Haven CT</wicri:noCountry></affiliation></author><author><name sortKey="Schreiber, Stefan" sort="Schreiber, Stefan" uniqKey="Schreiber S" first="Stefan" last="Schreiber">Stefan Schreiber</name><affiliation wicri:level="3"><nlm:aff id="A5">Christian-Albrechts-University Kiel, Institute of Clinical Molecular Biology, Kiel, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Christian-Albrechts-University Kiel, Institute of Clinical Molecular Biology, Kiel</wicri:regionArea><placeName><region type="land" nuts="2">Schleswig-Holstein</region><settlement type="city">Kiel</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A73">Department for General Internal Medicine, Christian-Albrechts-University, Kiel, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department for General Internal Medicine, Christian-Albrechts-University, Kiel</wicri:regionArea><placeName><region type="land" nuts="2">Schleswig-Holstein</region><settlement type="city">Kiel</settlement></placeName></affiliation></author><author><name sortKey="Daly, Mark J" sort="Daly, Mark J" uniqKey="Daly M" first="Mark J." last="Daly">Mark J. Daly</name><affiliation wicri:level="2"><nlm:aff id="A74">Massachusetts General Hospital, Harvard Medical School, Center for Human Genetic Research, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Massachusetts General Hospital, Harvard Medical School, Center for Human Genetic Research, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Barrett, Jeffrey C" sort="Barrett, Jeffrey C" uniqKey="Barrett J" first="Jeffrey C." last="Barrett">Jeffrey C. Barrett</name><affiliation wicri:level="1"><nlm:aff id="A1">Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Parkes, Miles" sort="Parkes, Miles" uniqKey="Parkes M" first="Miles" last="Parkes">Miles Parkes</name><affiliation wicri:level="4"><nlm:aff id="A8">Addenbrooke’s Hospital, University of Cambridge, Gastroenterology Research Unit, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Addenbrooke’s Hospital, University of Cambridge, Gastroenterology Research Unit, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Annese, Vito" sort="Annese, Vito" uniqKey="Annese V" first="Vito" last="Annese">Vito Annese</name><affiliation wicri:level="1"><nlm:aff id="A10">IRCCS-CSS Hospital, Unit of Gastroenterology, San Giovanni Rotondo, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>IRCCS-CSS Hospital, Unit of Gastroenterology, San Giovanni Rotondo</wicri:regionArea><wicri:noRegion>San Giovanni Rotondo</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A37">AOU Careggi, Unit of Gastroenterology SOD2, Florence, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>AOU Careggi, Unit of Gastroenterology SOD2, Florence</wicri:regionArea><wicri:noRegion>Florence</wicri:noRegion></affiliation></author><author><name sortKey="Hakonarson, Hakon" sort="Hakonarson, Hakon" uniqKey="Hakonarson H" first="Hakon" last="Hakonarson">Hakon Hakonarson</name><affiliation wicri:level="2"><nlm:aff id="A13">The Children’s Hospital of Philadelphia, Department of Pediatrics, Center for Pediatric Inflammatory Bowel Disease, Philadelphia, Pennsylvania, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Children’s Hospital of Philadelphia, Department of Pediatrics, Center for Pediatric Inflammatory Bowel Disease, Philadelphia, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A75">Center for Applied Genomics, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Applied Genomics, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Radford Smith, Graham" sort="Radford Smith, Graham" uniqKey="Radford Smith G" first="Graham" last="Radford-Smith">Graham Radford-Smith</name><affiliation wicri:level="1"><nlm:aff id="A76">Queensland Institute of Medical Research, IBD Research Group, Brisbane, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research, IBD Research Group, Brisbane</wicri:regionArea><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Duerr, Richard H" sort="Duerr, Richard H" uniqKey="Duerr R" first="Richard H." last="Duerr">Richard H. Duerr</name><affiliation wicri:level="2"><nlm:aff id="A11">University of Pittsburgh School of Medicine, Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Pittsburgh, Pennsylvania, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Pittsburgh School of Medicine, Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Pittsburgh, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A77">University of Pittsburgh Graduate School of Public Health, 130 Desoto Street, Pittsburgh, PA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Pittsburgh Graduate School of Public Health, 130 Desoto Street, Pittsburgh, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Vermeire, Severine" sort="Vermeire, Severine" uniqKey="Vermeire S" first="Séverine" last="Vermeire">Séverine Vermeire</name><affiliation wicri:level="1"><nlm:aff id="A49">University Hospital Gasthuisberg, Division of Gastroenterology, Leuven, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>University Hospital Gasthuisberg, Division of Gastroenterology, Leuven</wicri:regionArea><wicri:noRegion>Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Weersma, Rinse K" sort="Weersma, Rinse K" uniqKey="Weersma R" first="Rinse K." last="Weersma">Rinse K. Weersma</name><affiliation wicri:level="3"><nlm:aff id="A78">University Medical Center Groningen, Department of Gastroenterology, Groningen, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>University Medical Center Groningen, Department of Gastroenterology, Groningen</wicri:regionArea><placeName><settlement type="city">Groningue</settlement><region nuts="2" type="province">Groningue (province)</region></placeName></affiliation></author><author><name sortKey="Rioux, John D" sort="Rioux, John D" uniqKey="Rioux J" first="John D." last="Rioux">John D. Rioux</name><affiliation wicri:level="1"><nlm:aff id="A2">Université de Montréal, Medicine, Montréal, Québec, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Université de Montréal, Medicine, Montréal, Québec</wicri:regionArea><wicri:noRegion>Québec</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A3">Montreal Heart Institute, Research Center, Montréal, Québec, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Montreal Heart Institute, Research Center, Montréal, Québec</wicri:regionArea><wicri:noRegion>Québec</wicri:noRegion></affiliation></author></analytic><series><title level="j">Nature genetics</title><idno type="ISSN">1061-4036</idno><idno type="eISSN">1546-1718</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Genome-wide association studies (GWAS) and candidate gene studies in ulcerative colitis (UC) have identified 18 susceptibility loci. We conducted a meta-analysis of 6 UC GWAS, comprising 6,687 cases and 19,718 controls, and followed-up the top association signals in 9,628 cases and 12,917 controls. We identified 29 additional risk loci (P<5×10<sup>-8</sup>), increasing the number of UC associated loci to 47. After annotating associated regions using GRAIL, eQTL data and correlations with non-synonymous SNPs, we identified many candidate genes providing potentially important insights into disease pathogenesis, including <italic>IL1R2, IL8RA/B, IL7R, IL12B, DAP, PRDM1, JAK2, IRF5, GNA12</italic> and <italic>LSP1</italic>. The total number of confirmed inflammatory bowel disease (IBD) risk loci is now 99, including a minimum of 28 shared association signals between Crohn’s disease (CD) and UC.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Xavier, Rj" uniqKey="Xavier R">RJ Xavier</name></author><author><name sortKey="Podolsky, Dk" uniqKey="Podolsky D">DK Podolsky</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Festen, Ea" uniqKey="Festen E">EA Festen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Franke, A" uniqKey="Franke A">A Franke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mcgovern, Dp" uniqKey="Mcgovern D">DP McGovern</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Franke, A" uniqKey="Franke A">A Franke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dideberg, V" uniqKey="Dideberg V">V Dideberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Asano, K" uniqKey="Asano K">K Asano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhernakova, A" uniqKey="Zhernakova A">A Zhernakova</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kugathasan, S" uniqKey="Kugathasan S">S Kugathasan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dubois, Pc" uniqKey="Dubois P">PC Dubois</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kuester, D" uniqKey="Kuester D">D Kuester</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Koren, I" uniqKey="Koren I">I Koren</name></author><author><name sortKey="Reem, E" uniqKey="Reem E">E Reem</name></author><author><name sortKey="Kimchi, A" uniqKey="Kimchi A">A Kimchi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Franke, A" uniqKey="Franke A">A Franke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Turner, Ca" uniqKey="Turner C">CA Turner</name></author><author><name sortKey="Mack, Dh" uniqKey="Mack D">DH Mack</name></author><author><name sortKey="Davis, Mm" uniqKey="Davis M">MM Davis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Martins, Ga" uniqKey="Martins G">GA Martins</name></author><author><name sortKey="Cimmino, L" uniqKey="Cimmino L">L Cimmino</name></author><author><name sortKey="Liao, J" uniqKey="Liao J">J Liao</name></author><author><name sortKey="Magnusdottir, E" uniqKey="Magnusdottir E">E Magnusdottir</name></author><author><name sortKey="Calame, K" uniqKey="Calame K">K Calame</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kallies, A" uniqKey="Kallies A">A Kallies</name></author><author><name sortKey="Xin, A" uniqKey="Xin A">A Xin</name></author><author><name sortKey="Belz, Gt" uniqKey="Belz G">GT Belz</name></author><author><name sortKey="Nutt, Sl" uniqKey="Nutt S">SL Nutt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Grenningloh, R" uniqKey="Grenningloh R">R Grenningloh</name></author><author><name sortKey="Kang, By" uniqKey="Kang B">BY Kang</name></author><author><name sortKey="Ho, Ic" uniqKey="Ho I">IC Ho</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Moisan, J" uniqKey="Moisan J">J Moisan</name></author><author><name sortKey="Grenningloh, R" uniqKey="Grenningloh R">R Grenningloh</name></author><author><name sortKey="Bettelli, E" uniqKey="Bettelli E">E Bettelli</name></author><author><name sortKey="Oukka, M" uniqKey="Oukka M">M Oukka</name></author><author><name sortKey="Ho, Ic" uniqKey="Ho I">IC Ho</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sabath, E" uniqKey="Sabath E">E Sabath</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bettelli, E" uniqKey="Bettelli E">E Bettelli</name></author><author><name sortKey="Korn, T" uniqKey="Korn T">T Korn</name></author><author><name sortKey="Oukka, M" uniqKey="Oukka M">M Oukka</name></author><author><name sortKey="Kuchroo, Vk" uniqKey="Kuchroo V">VK Kuchroo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Steinberg, Mw" uniqKey="Steinberg M">MW Steinberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Maerten, P" uniqKey="Maerten P">P Maerten</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mahida, Yr" uniqKey="Mahida Y">YR Mahida</name></author><author><name sortKey="Wu, K" uniqKey="Wu K">K Wu</name></author><author><name sortKey="Jewell, Dp" uniqKey="Jewell D">DP Jewell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Williams, Ej" uniqKey="Williams E">EJ Williams</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Noble, Cl" uniqKey="Noble C">CL Noble</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schluns, Ks" uniqKey="Schluns K">KS Schluns</name></author><author><name sortKey="Kieper, Wc" uniqKey="Kieper W">WC Kieper</name></author><author><name sortKey="Jameson, Sc" uniqKey="Jameson S">SC Jameson</name></author><author><name sortKey="Lefrancois, L" uniqKey="Lefrancois L">L Lefrancois</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yamazaki, M" uniqKey="Yamazaki M">M Yamazaki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gregory, Sg" uniqKey="Gregory S">SG Gregory</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fumagalli, M" uniqKey="Fumagalli M">M Fumagalli</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pandey, Ak" uniqKey="Pandey A">AK Pandey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, L" uniqKey="Liu L">L Liu</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9216904</journal-id><journal-id journal-id-type="pubmed-jr-id">2419</journal-id><journal-id journal-id-type="nlm-ta">Nat Genet</journal-id><journal-id journal-id-type="iso-abbrev">Nat. Genet.</journal-id><journal-title-group><journal-title>Nature genetics</journal-title></journal-title-group><issn pub-type="ppub">1061-4036</issn><issn pub-type="epub">1546-1718</issn></journal-meta><article-meta><article-id pub-id-type="pmid">21297633</article-id><article-id pub-id-type="pmc">3084597</article-id><article-id pub-id-type="doi">10.1038/ng.764</article-id><article-id pub-id-type="manuscript">NIHMS265993</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Anderson</surname><given-names>Carl A.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Boucher</surname><given-names>Gabrielle</given-names></name><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A3">3</xref><xref rid="FN2" ref-type="author-notes">79</xref></contrib><contrib contrib-type="author"><name><surname>Lees</surname><given-names>Charlie W.</given-names></name><xref ref-type="aff" rid="A4">4</xref><xref rid="FN2" ref-type="author-notes">79</xref></contrib><contrib contrib-type="author"><name><surname>Franke</surname><given-names>Andre</given-names></name><xref ref-type="aff" rid="A5">5</xref><xref rid="FN2" ref-type="author-notes">79</xref></contrib><contrib contrib-type="author"><name><surname>D’Amato</surname><given-names>Mauro</given-names></name><xref ref-type="aff" rid="A6">6</xref><xref rid="FN2" ref-type="author-notes">79</xref></contrib><contrib contrib-type="author"><name><surname>Taylor</surname><given-names>Kent D.</given-names></name><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author"><name><surname>Lee</surname><given-names>James C.</given-names></name><xref ref-type="aff" rid="A8">8</xref></contrib><contrib contrib-type="author"><name><surname>Goyette</surname><given-names>Philippe</given-names></name><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Imielinski</surname><given-names>Marcin</given-names></name><xref ref-type="aff" rid="A9">9</xref></contrib><contrib contrib-type="author"><name><surname>Latiano</surname><given-names>Anna</given-names></name><xref ref-type="aff" rid="A10">10</xref></contrib><contrib contrib-type="author"><name><surname>Lagacé</surname><given-names>Caroline</given-names></name><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Scott</surname><given-names>Regan</given-names></name><xref ref-type="aff" rid="A11">11</xref></contrib><contrib contrib-type="author"><name><surname>Amininejad</surname><given-names>Leila</given-names></name><xref ref-type="aff" rid="A12">12</xref></contrib><contrib contrib-type="author"><name><surname>Bumpstead</surname><given-names>Suzannah</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Baidoo</surname><given-names>Leonard</given-names></name><xref ref-type="aff" rid="A11">11</xref></contrib><contrib contrib-type="author"><name><surname>Baldassano</surname><given-names>Robert N.</given-names></name><xref ref-type="aff" rid="A13">13</xref></contrib><contrib contrib-type="author"><name><surname>Barclay</surname><given-names>Murray</given-names></name><xref ref-type="aff" rid="A14">14</xref></contrib><contrib contrib-type="author"><name><surname>Bayless</surname><given-names>Theodore M.</given-names></name><xref ref-type="aff" rid="A15">15</xref></contrib><contrib contrib-type="author"><name><surname>Brand</surname><given-names>Stephan</given-names></name><xref ref-type="aff" rid="A16">16</xref></contrib><contrib contrib-type="author"><name><surname>Büning</surname><given-names>Carsten</given-names></name><xref ref-type="aff" rid="A17">17</xref></contrib><contrib contrib-type="author"><name><surname>Colombel</surname><given-names>Jean-Frédéric</given-names></name><xref ref-type="aff" rid="A18">18</xref></contrib><contrib contrib-type="author"><name><surname>Denson</surname><given-names>Lee A.</given-names></name><xref ref-type="aff" rid="A19">19</xref></contrib><contrib contrib-type="author"><name><surname>De Vos</surname><given-names>Martine</given-names></name><xref ref-type="aff" rid="A20">20</xref></contrib><contrib contrib-type="author"><name><surname>Dubinsky</surname><given-names>Marla</given-names></name><xref ref-type="aff" rid="A21">21</xref></contrib><contrib contrib-type="author"><name><surname>Edwards</surname><given-names>Cathryn</given-names></name><xref ref-type="aff" rid="A22">22</xref></contrib><contrib contrib-type="author"><name><surname>Ellinghaus</surname><given-names>David</given-names></name><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Fehrmann</surname><given-names>Rudolf S.N.</given-names></name><xref ref-type="aff" rid="A23">23</xref></contrib><contrib contrib-type="author"><name><surname>Floyd</surname><given-names>James A.B.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Florin</surname><given-names>Tim</given-names></name><xref ref-type="aff" rid="A24">24</xref></contrib><contrib contrib-type="author"><name><surname>Franchimont</surname><given-names>Denis</given-names></name><xref ref-type="aff" rid="A25">25</xref></contrib><contrib contrib-type="author"><name><surname>Franke</surname><given-names>Lude</given-names></name><xref ref-type="aff" rid="A23">23</xref></contrib><contrib contrib-type="author"><name><surname>Georges</surname><given-names>Michel</given-names></name><xref ref-type="aff" rid="A26">26</xref></contrib><contrib contrib-type="author"><name><surname>Glas</surname><given-names>Jürgen</given-names></name><xref ref-type="aff" rid="A16">16</xref></contrib><contrib contrib-type="author"><name><surname>Glazer</surname><given-names>Nicole L.</given-names></name><xref ref-type="aff" rid="A27">27</xref></contrib><contrib contrib-type="author"><name><surname>Guthery</surname><given-names>Stephen L.</given-names></name><xref ref-type="aff" rid="A28">28</xref></contrib><contrib contrib-type="author"><name><surname>Haritunians</surname><given-names>Talin</given-names></name><xref ref-type="aff" rid="A29">29</xref></contrib><contrib contrib-type="author"><name><surname>Hayward</surname><given-names>Nicholas K.</given-names></name><xref ref-type="aff" rid="A30">30</xref></contrib><contrib contrib-type="author"><name><surname>Hugot</surname><given-names>Jean-Pierre</given-names></name><xref ref-type="aff" rid="A31">31</xref></contrib><contrib contrib-type="author"><name><surname>Jobin</surname><given-names>Gilles</given-names></name><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A32">32</xref></contrib><contrib contrib-type="author"><name><surname>Laukens</surname><given-names>Debby</given-names></name><xref ref-type="aff" rid="A20">20</xref></contrib><contrib contrib-type="author"><name><surname>Lawrance</surname><given-names>Ian</given-names></name><xref ref-type="aff" rid="A33">33</xref></contrib><contrib contrib-type="author"><name><surname>Lémann</surname><given-names>Marc</given-names></name><xref ref-type="aff" rid="A34">34</xref></contrib><contrib contrib-type="author"><name><surname>Levine</surname><given-names>Arie</given-names></name><xref ref-type="aff" rid="A35">35</xref></contrib><contrib contrib-type="author"><name><surname>Libioulle</surname><given-names>Cecile</given-names></name><xref ref-type="aff" rid="A36">36</xref></contrib><contrib contrib-type="author"><name><surname>Louis</surname><given-names>Edouard</given-names></name><xref ref-type="aff" rid="A36">36</xref></contrib><contrib contrib-type="author"><name><surname>McGovern</surname><given-names>Dermot P.</given-names></name><xref ref-type="aff" rid="A7">7</xref><xref ref-type="aff" rid="A29">29</xref></contrib><contrib contrib-type="author"><name><surname>Milla</surname><given-names>Monica</given-names></name><xref ref-type="aff" rid="A37">37</xref></contrib><contrib contrib-type="author"><name><surname>Montgomery</surname><given-names>Grant W.</given-names></name><xref ref-type="aff" rid="A30">30</xref></contrib><contrib contrib-type="author"><name><surname>Morley</surname><given-names>Katherine I.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Mowat</surname><given-names>Craig</given-names></name><xref ref-type="aff" rid="A38">38</xref></contrib><contrib contrib-type="author"><name><surname>Ng</surname><given-names>Aylwin</given-names></name><xref ref-type="aff" rid="A39">39</xref><xref ref-type="aff" rid="A40">40</xref></contrib><contrib contrib-type="author"><name><surname>Newman</surname><given-names>William</given-names></name><xref ref-type="aff" rid="A41">41</xref></contrib><contrib contrib-type="author"><name><surname>Ophoff</surname><given-names>Roel A</given-names></name><xref ref-type="aff" rid="A42">42</xref></contrib><contrib contrib-type="author"><name><surname>Papi</surname><given-names>Laura</given-names></name><xref ref-type="aff" rid="A43">43</xref></contrib><contrib contrib-type="author"><name><surname>Palmieri</surname><given-names>Orazio</given-names></name><xref ref-type="aff" rid="A10">10</xref></contrib><contrib contrib-type="author"><name><surname>Peyrin-Biroulet</surname><given-names>Laurent</given-names></name><xref ref-type="aff" rid="A44">44</xref></contrib><contrib contrib-type="author"><name><surname>Panés</surname><given-names>Julián</given-names></name><xref ref-type="aff" rid="A45">45</xref></contrib><contrib contrib-type="author"><name><surname>Phillips</surname><given-names>Anne</given-names></name><xref ref-type="aff" rid="A38">38</xref></contrib><contrib contrib-type="author"><name><surname>Prescott</surname><given-names>Natalie J.</given-names></name><xref ref-type="aff" rid="A46">46</xref></contrib><contrib contrib-type="author"><name><surname>Proctor</surname><given-names>Deborah D.</given-names></name><xref ref-type="aff" rid="A47">47</xref></contrib><contrib contrib-type="author"><name><surname>Roberts</surname><given-names>Rebecca</given-names></name><xref ref-type="aff" rid="A14">14</xref></contrib><contrib contrib-type="author"><name><surname>Russell</surname><given-names>Richard</given-names></name><xref ref-type="aff" rid="A48">48</xref></contrib><contrib contrib-type="author"><name><surname>Rutgeerts</surname><given-names>Paul</given-names></name><xref ref-type="aff" rid="A49">49</xref></contrib><contrib contrib-type="author"><name><surname>Sanderson</surname><given-names>Jeremy</given-names></name><xref ref-type="aff" rid="A50">50</xref></contrib><contrib contrib-type="author"><name><surname>Sans</surname><given-names>Miquel</given-names></name><xref ref-type="aff" rid="A51">51</xref></contrib><contrib contrib-type="author"><name><surname>Schumm</surname><given-names>Philip</given-names></name><xref ref-type="aff" rid="A52">52</xref></contrib><contrib contrib-type="author"><name><surname>Seibold</surname><given-names>Frank</given-names></name><xref ref-type="aff" rid="A53">53</xref></contrib><contrib contrib-type="author"><name><surname>Sharma</surname><given-names>Yashoda</given-names></name><xref ref-type="aff" rid="A47">47</xref></contrib><contrib contrib-type="author"><name><surname>Simms</surname><given-names>Lisa</given-names></name><xref ref-type="aff" rid="A30">30</xref></contrib><contrib contrib-type="author"><name><surname>Seielstad</surname><given-names>Mark</given-names></name><xref ref-type="aff" rid="A54">54</xref><xref ref-type="aff" rid="A55">55</xref></contrib><contrib contrib-type="author"><name><surname>Steinhart</surname><given-names>A. Hillary</given-names></name><xref ref-type="aff" rid="A56">56</xref></contrib><contrib contrib-type="author"><name><surname>Targan</surname><given-names>Stephan R.</given-names></name><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author"><name><surname>van den Berg</surname><given-names>Leonard H.</given-names></name><xref ref-type="aff" rid="A57">57</xref></contrib><contrib contrib-type="author"><name><surname>Vatn</surname><given-names>Morten</given-names></name><xref ref-type="aff" rid="A58">58</xref></contrib><contrib contrib-type="author"><name><surname>Verspaget</surname><given-names>Hein</given-names></name><xref ref-type="aff" rid="A59">59</xref></contrib><contrib contrib-type="author"><name><surname>Walters</surname><given-names>Thomas</given-names></name><xref ref-type="aff" rid="A60">60</xref></contrib><contrib contrib-type="author"><name><surname>Wijmenga</surname><given-names>Cisca</given-names></name><xref ref-type="aff" rid="A23">23</xref></contrib><contrib contrib-type="author"><name><surname>Wilson</surname><given-names>David C.</given-names></name><xref ref-type="aff" rid="A48">48</xref><xref ref-type="aff" rid="A61">61</xref></contrib><contrib contrib-type="author"><name><surname>Westra</surname><given-names>Harm-Jan</given-names></name><xref ref-type="aff" rid="A23">23</xref></contrib><contrib contrib-type="author"><name><surname>Xavier</surname><given-names>Ramnik J.</given-names></name><xref ref-type="aff" rid="A39">39</xref><xref ref-type="aff" rid="A40">40</xref></contrib><contrib contrib-type="author"><name><surname>Zhao</surname><given-names>Zhen Z.</given-names></name><xref ref-type="aff" rid="A30">30</xref></contrib><contrib contrib-type="author"><name><surname>Ponsioen</surname><given-names>Cyriel Y.</given-names></name><xref ref-type="aff" rid="A62">62</xref></contrib><contrib contrib-type="author"><name><surname>Andersen</surname><given-names>Vibeke</given-names></name><xref ref-type="aff" rid="A63">63</xref></contrib><contrib contrib-type="author"><name><surname>Torkvist</surname><given-names>Leif</given-names></name><xref ref-type="aff" rid="A64">64</xref></contrib><contrib contrib-type="author"><name><surname>Gazouli</surname><given-names>Maria</given-names></name><xref ref-type="aff" rid="A65">65</xref></contrib><contrib contrib-type="author"><name><surname>Anagnou</surname><given-names>Nicholas P.</given-names></name><xref ref-type="aff" rid="A65">65</xref></contrib><contrib contrib-type="author"><name><surname>Karlsen</surname><given-names>Tom H.</given-names></name><xref ref-type="aff" rid="A58">58</xref></contrib><contrib contrib-type="author"><name><surname>Kupcinskas</surname><given-names>Limas</given-names></name><xref ref-type="aff" rid="A66">66</xref></contrib><contrib contrib-type="author"><name><surname>Sventoraityte</surname><given-names>Jurgita</given-names></name><xref ref-type="aff" rid="A66">66</xref></contrib><contrib contrib-type="author"><name><surname>Mansfield</surname><given-names>John C.</given-names></name><xref ref-type="aff" rid="A67">67</xref></contrib><contrib contrib-type="author"><name><surname>Kugathasan</surname><given-names>Subra</given-names></name><xref ref-type="aff" rid="A68">68</xref></contrib><contrib contrib-type="author"><name><surname>Silverberg</surname><given-names>Mark S.</given-names></name><xref ref-type="aff" rid="A56">56</xref></contrib><contrib contrib-type="author"><name><surname>Halfvarson</surname><given-names>Jonas</given-names></name><xref ref-type="aff" rid="A69">69</xref></contrib><contrib contrib-type="author"><name><surname>Rotter</surname><given-names>Jerome I.</given-names></name><xref ref-type="aff" rid="A29">29</xref></contrib><contrib contrib-type="author"><name><surname>Mathew</surname><given-names>Christopher G.</given-names></name><xref ref-type="aff" rid="A46">46</xref></contrib><contrib contrib-type="author"><name><surname>Griffiths</surname><given-names>Anne M.</given-names></name><xref ref-type="aff" rid="A60">60</xref></contrib><contrib contrib-type="author"><name><surname>Gearry</surname><given-names>Richard</given-names></name><xref ref-type="aff" rid="A14">14</xref></contrib><contrib contrib-type="author"><name><surname>Ahmad</surname><given-names>Tariq</given-names></name><xref ref-type="aff" rid="A70">70</xref></contrib><contrib contrib-type="author"><name><surname>Brant</surname><given-names>Steven R.</given-names></name><xref ref-type="aff" rid="A15">15</xref></contrib><contrib contrib-type="author"><name><surname>Chamaillard</surname><given-names>Mathias</given-names></name><xref ref-type="aff" rid="A71">71</xref></contrib><contrib contrib-type="author"><name><surname>Satsangi</surname><given-names>Jack</given-names></name><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Cho</surname><given-names>Judy H.</given-names></name><xref ref-type="aff" rid="A47">47</xref><xref ref-type="aff" rid="A72">72</xref></contrib><contrib contrib-type="author"><name><surname>Schreiber</surname><given-names>Stefan</given-names></name><xref ref-type="aff" rid="A5">5</xref><xref ref-type="aff" rid="A73">73</xref></contrib><contrib contrib-type="author"><name><surname>Daly</surname><given-names>Mark J.</given-names></name><xref ref-type="aff" rid="A74">74</xref></contrib><contrib contrib-type="author"><name><surname>Barrett</surname><given-names>Jeffrey C.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Parkes</surname><given-names>Miles</given-names></name><xref ref-type="aff" rid="A8">8</xref></contrib><contrib contrib-type="author"><name><surname>Annese</surname><given-names>Vito</given-names></name><xref ref-type="aff" rid="A10">10</xref><xref ref-type="aff" rid="A37">37</xref></contrib><contrib contrib-type="author"><name><surname>Hakonarson</surname><given-names>Hakon</given-names></name><xref ref-type="aff" rid="A13">13</xref><xref ref-type="aff" rid="A75">75</xref><xref rid="FN3" ref-type="author-notes">80</xref></contrib><contrib contrib-type="author"><name><surname>Radford-Smith</surname><given-names>Graham</given-names></name><xref ref-type="aff" rid="A76">76</xref><xref rid="FN3" ref-type="author-notes">80</xref></contrib><contrib contrib-type="author"><name><surname>Duerr</surname><given-names>Richard H.</given-names></name><xref ref-type="aff" rid="A11">11</xref><xref ref-type="aff" rid="A77">77</xref><xref rid="FN3" ref-type="author-notes">80</xref></contrib><contrib contrib-type="author"><name><surname>Vermeire</surname><given-names>Séverine</given-names></name><xref ref-type="aff" rid="A49">49</xref><xref rid="FN3" ref-type="author-notes">80</xref></contrib><contrib contrib-type="author"><name><surname>Weersma</surname><given-names>Rinse K.</given-names></name><xref ref-type="aff" rid="A78">78</xref><xref rid="FN3" ref-type="author-notes">80</xref></contrib><contrib contrib-type="author"><name><surname>Rioux</surname><given-names>John D.</given-names></name><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A3">3</xref></contrib></contrib-group><aff id="A1"><label>1</label>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK</aff><aff id="A2"><label>2</label>Université de Montréal, Medicine, Montréal, Québec, Canada</aff><aff id="A3"><label>3</label>Montreal Heart Institute, Research Center, Montréal, Québec, Canada</aff><aff id="A4"><label>4</label>University of Edinburgh, Western General Hospital, Gastrointestinal Unit, Molecular Medicine Centre, Edinburgh, UK</aff><aff id="A5"><label>5</label>Christian-Albrechts-University Kiel, Institute of Clinical Molecular Biology, Kiel, Germany</aff><aff id="A6"><label>6</label>Karolinska Institute, Department of Biosciences and Nutrition, Stockholm, Sweden</aff><aff id="A7"><label>7</label>Cedars-Sinai Medical Center, Inflammatory Bowel and Immunobiology Research Institute, Los Angeles, California, USA</aff><aff id="A8"><label>8</label>Addenbrooke’s Hospital, University of Cambridge, Gastroenterology Research Unit, Cambridge, UK</aff><aff id="A9"><label>9</label>The Children’s Hospital of Philadelphia, Center for Applied Genomics, Philadelphia, Pennsylvania, USA</aff><aff id="A10"><label>10</label>IRCCS-CSS Hospital, Unit of Gastroenterology, San Giovanni Rotondo, Italy</aff><aff id="A11"><label>11</label>University of Pittsburgh School of Medicine, Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Pittsburgh, Pennsylvania, USA</aff><aff id="A12"><label>12</label>Erasmus Hospital, Free University of Brussels, Department of Gastroenterology, Brussels, Belgium</aff><aff id="A13"><label>13</label>The Children’s Hospital of Philadelphia, Department of Pediatrics, Center for Pediatric Inflammatory Bowel Disease, Philadelphia, Pennsylvania, USA</aff><aff id="A14"><label>14</label>University of Otago, Department of Medicine, Christchurch, New Zealand</aff><aff id="A15"><label>15</label>Johns Hopkins University School of Medicine, Meyeroff Inflammatory Bowel Disease Center, Dept. of Medicine, Baltimore, Maryland, USA</aff><aff id="A16"><label>16</label>University Hospital Munich, Department of Medicine II, Munich, Germany</aff><aff id="A17"><label>17</label>Universitätsmedizin Berlin, Department of Gastroenterology, Charité, Campus Mitte, Berlin, Germany</aff><aff id="A18"><label>18</label>Université de Lille Department of Hepato-Gastroenterology, Lille, France</aff><aff id="A19"><label>19</label>Cincinnati Children’s Hospital Medical Center, Pediatric Gastroenterology, Cincinnati, Ohio, USA</aff><aff id="A20"><label>20</label>Ghent University Hospital, Department of Hepatology and Gastroenterology, Ghent, Belgium</aff><aff id="A21"><label>21</label>Cedars-Sinai Medical Center, Department of Pediatrics, Los Angeles, California, USA</aff><aff id="A22"><label>22</label>Torbay Hospital, Department of Gastroenterology, Torbay, Devon, UK</aff><aff id="A23"><label>23</label>University Medical Center Groningen, Department of Genetics, Groningen, the Netherlands</aff><aff id="A24"><label>24</label>Mater Health Services, Department of Gastroenterology, Brisbane, Australia</aff><aff id="A25"><label>25</label>Erasmus Hospital, Free University of Brussels, Department of Gastroenterology, Brussels, Belgium</aff><aff id="A26"><label>26</label>University of Liège, Department of Genetics, Faculty of Veterinary Medicine, Liège, Belgium</aff><aff id="A27"><label>27</label>University of Washington, Cardiovascular Health Research Unit, Department of Internal Medicine, Seattle, Washington, USA</aff><aff id="A28"><label>28</label>University of Utah School of Medicine, Department of Pediatrics, Salt Lake City, Utah, USA</aff><aff id="A29"><label>29</label>Cedars-Sinai Medical Center, Medical Genetics Institute, Los Angeles, California, USA</aff><aff id="A30"><label>30</label>Queensland Institute of Medical Research, Genetic Epidemiology, Brisbane, Australia</aff><aff id="A31"><label>31</label>Université Paris Diderot & INSERM & Hopital Robert Debre APHP, Gastroenterology, Paris, France</aff><aff id="A32"><label>32</label>Hôpital Maisonneuve-Rosemont, Dept of Gastroenterology, Montréal, Québec, Canada</aff><aff id="A33"><label>33</label>The University of Western Australia, School of Medicine and Pharmacology, Fremantle, Australia</aff><aff id="A34"><label>34</label>Université Paris Diderot, GETAID group, Paris, France</aff><aff id="A35"><label>35</label>Tel Aviv University, Pediatric Gastroenterology Unit, Wolfson Medical Center and Sackler School of Medicine, Tel Aviv, Israel</aff><aff id="A36"><label>36</label>Centre Hospitalier Universitaire Université de Liège, Division of Gastroenterology, Liège, Belgium</aff><aff id="A37"><label>37</label>AOU Careggi, Unit of Gastroenterology SOD2, Florence, Italy</aff><aff id="A38"><label>38</label>Ninewells Hospital and Medical School, Dept of Medicine, Dundee, UK</aff><aff id="A39"><label>39</label>Massachusetts General Hospital, Harvard Medical School, Gastroenterology Unit Boston, Massachusetts, USA</aff><aff id="A40"><label>40</label>Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, Massachusetts, USA</aff><aff id="A41"><label>41</label>University of Manchester Department of Medical Genetics, Manchester, UK</aff><aff id="A42"><label>42</label>University Medical Center Utrecht, Department of Medical Genetics, Utrecht, Netherlands</aff><aff id="A43"><label>43</label>University of Florence, Institute of Human Genetics, Florence, Italy</aff><aff id="A44"><label>44</label>University Hospital of Nancy, Department of Hepato-Gastroenterology, Vandoeuvre-lès-Nancy, France</aff><aff id="A45"><label>45</label>Hospital Clínic de Barcelona, IDIBAPS, CIBERehd, Department of Gastroenterology, Barcelona, Spain</aff><aff id="A46"><label>46</label>King’s College London School of Medicine, Guy’s Hospital, Department of Medical and Molecular Genetics, London, UK</aff><aff id="A47"><label>47</label>Yale University, Section of Digestive Diseases, Department of Medicine, New Haven, Connecticut, USA</aff><aff id="A48"><label>48</label>Royal Hospital for Sick Children, Paediatric Gastroenterology and Nutrition, Glasgow, UK</aff><aff id="A49"><label>49</label>University Hospital Gasthuisberg, Division of Gastroenterology, Leuven, Belgium</aff><aff id="A50"><label>50</label>Guy’s & St Thomas’ NHS Foundation Trust, St Thomas’ Hospital, Dept Gastroenterology, London, UK</aff><aff id="A51"><label>51</label>Hospital Clínic de Barcelona, IDIBAPS, CIBERehd, Department of Gastroenterology, Barcelona, Spain</aff><aff id="A52"><label>52</label>University of Chicago, Department of Health Studies, Chicago, Illinois, USA</aff><aff id="A53"><label>53</label>University of Bern, Division of Gastroenterology, Inselspital, Bern, Switzerland</aff><aff id="A54"><label>54</label>Genome Institute of Singapore, Human Genetics, Singapore</aff><aff id="A55"><label>55</label>Institute for Human Genetics, University of California San Fransisco, San Francisco, California, USA</aff><aff id="A56"><label>56</label>University of Toronto, Mount Sinai Hospital Inflammatory Bowel Disease Centre, Toronto, Ontario, Canada</aff><aff id="A57"><label>57</label>Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Department of Neurology, Utrecht, the Netherlands</aff><aff id="A58"><label>58</label>Rikshospitalet University Hospital, Medical Department, Oslo, Norway</aff><aff id="A59"><label>59</label>Leiden University Medical Center, Experimental Gastroenterology, Leiden, the Netherlands</aff><aff id="A60"><label>60</label>The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada</aff><aff id="A61"><label>61</label>Child Life and Health, University of Edinburgh, Scotland</aff><aff id="A62"><label>62</label>Academic Medical Center, Department of Gastroenterology, Amsterdam, the Netherlands</aff><aff id="A63"><label>63</label>Viborg Regional Hospital, Medical Department, Viborg, Denmark</aff><aff id="A64"><label>64</label>Karolinska Institutet, Department of Clinical Science Intervention and Technology, Stockholm, Sweden</aff><aff id="A65"><label>65</label>University of Athens, Department of Biology, School of Medicine, Athens, Greece</aff><aff id="A66"><label>66</label>Kaunas University of medicine, Department of Gastroenterology, Kaunas, Lithuania</aff><aff id="A67"><label>67</label>Newcastle University, Institute of Human Genetics, Newcastle upon Tyne, UK</aff><aff id="A68"><label>68</label>Emory School of Medicine, Department of Genetics and Department of Pediatrics, Atlanta, Georgia, USA</aff><aff id="A69"><label>69</label>Örebro University Hospital, Department of Medicine, Örebro, Sweden</aff><aff id="A70"><label>70</label>Peninsula College of Medicine and Dentistry, Barrack Road, Exeter, UK</aff><aff id="A71"><label>71</label>Inserm, U1019, Lille, France</aff><aff id="A72"><label>72</label>Yale University, Department of Genetics, Yale School of Medicine, New Haven CT</aff><aff id="A73"><label>73</label>Department for General Internal Medicine, Christian-Albrechts-University, Kiel, Germany</aff><aff id="A74"><label>74</label>Massachusetts General Hospital, Harvard Medical School, Center for Human Genetic Research, Boston, Massachusetts, USA</aff><aff id="A75"><label>75</label>Center for Applied Genomics, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA</aff><aff id="A76"><label>76</label>Queensland Institute of Medical Research, IBD Research Group, Brisbane, Australia</aff><aff id="A77"><label>77</label>University of Pittsburgh Graduate School of Public Health, 130 Desoto Street, Pittsburgh, PA, USA</aff><aff id="A78"><label>78</label>University Medical Center Groningen, Department of Gastroenterology, Groningen, the Netherlands</aff><author-notes><corresp id="FN1">Correspondence should be addressed to C.A.A. (<email>carl.anderson@sanger.ac.uk</email>)or J.D.R. (<email>john.david.rioux@umontreal.ca</email>)</corresp><fn id="FN2" fn-type="equal"><label>79</label><p>These authors contributed equally to this work.</p></fn><fn id="FN3" fn-type="equal"><label>80</label><p>These authors contributed equally to this work.</p></fn></author-notes><pub-date pub-type="nihms-submitted"><day>5</day><month>4</month><year>2011</year></pub-date><pub-date pub-type="epub"><day>06</day><month>2</month><year>2011</year></pub-date><pub-date pub-type="ppub"><month>3</month><year>2011</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>9</month><year>2011</year></pub-date><volume>43</volume><issue>3</issue><fpage>246</fpage><lpage>252</lpage><pmc-comment>elocation-id from pubmed: 10.1038/ng.764</pmc-comment>
<permissions><license xlink:href="http://www.nature.com/authors/editorial_policies/license.html#terms"><license-p>Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:<ext-link ext-link-type="uri" xlink:href="http://www.nature.com/authors/editorial_policies/license.html#terms">http://www.nature.com/authors/editorial_policies/license.html#terms</ext-link></license-p></license></permissions><abstract><p id="P1">Genome-wide association studies (GWAS) and candidate gene studies in ulcerative colitis (UC) have identified 18 susceptibility loci. We conducted a meta-analysis of 6 UC GWAS, comprising 6,687 cases and 19,718 controls, and followed-up the top association signals in 9,628 cases and 12,917 controls. We identified 29 additional risk loci (P<5×10<sup>-8</sup>), increasing the number of UC associated loci to 47. After annotating associated regions using GRAIL, eQTL data and correlations with non-synonymous SNPs, we identified many candidate genes providing potentially important insights into disease pathogenesis, including <italic>IL1R2, IL8RA/B, IL7R, IL12B, DAP, PRDM1, JAK2, IRF5, GNA12</italic> and <italic>LSP1</italic>. The total number of confirmed inflammatory bowel disease (IBD) risk loci is now 99, including a minimum of 28 shared association signals between Crohn’s disease (CD) and UC.</p></abstract></article-meta></front><floats-group><table-wrap id="T1" position="float" orientation="landscape"><label>Table 1</label><caption><title>Association results and <italic>in silico</italic> analyses for the 18 previously confirmed (P<5×10<sup>-8</sup>) ulcerative colitis (UC) loci</title><p>Left-right association boundaries are given for each index SNP (see <xref rid="SD2" ref-type="supplementary-material">Online Methods</xref>). RAF = risk allele frequency. OR is estimated using the meta-analysis cohort only. Known associations represent phenotypes previously associated with the locus at P<5×10<sup>-8</sup>). AS = ankylosing spondylitis, Ast = Asthma, BD = Behçet’s disease, CD = Crohn’s disease, CeD = celiac disease, Graves’ disease = GD, HL = Hodgkin’s lymphoma, MS = multiple sclerosis, PBC = primary biliary sclerosis, Ps = psoriasis, RA = rheumatoid arthritis, SLE = systemic lupus erythematosus, T1D = type 1 diabetes and WBC = white blood cell count. Candidate genes of interest are listed. Those in bold were highlighted by <italic>in silico</italic> analyses (GRAIL connectivity and/or presence of an eQTL or nonsynonymous SNP. See <xref rid="SD2" ref-type="supplementary-material">Online Methods and Supplementary Table 7</xref> for more details).</p></caption><table frame="hsides" rules="groups"><thead><tr><th align="left" rowspan="1" colspan="1">dbSNP ID</th><th align="left" rowspan="1" colspan="1">Chr.</th><th align="left" rowspan="1" colspan="1">Left-right(Mb)</th><th align="center" rowspan="1" colspan="1">Risk Allele</th><th align="center" rowspan="1" colspan="1">Allele frequency in controls</th><th align="center" rowspan="1" colspan="1">P-value (meta)</th><th align="center" rowspan="1" colspan="1">OR (95% CI)</th><th align="left" rowspan="1" colspan="1">Association reported with other phenotypes</th><th align="left" rowspan="1" colspan="1">Positional candidate genes of interest</th></tr></thead><tbody><tr><td align="left" rowspan="1" colspan="1">rs6426833</td><td align="left" rowspan="1" colspan="1">1p36</td><td align="left" rowspan="1" colspan="1">19.93-20.18</td><td align="center" rowspan="1" colspan="1">A</td><td align="center" rowspan="1" colspan="1">0.541</td><td align="center" rowspan="1" colspan="1">3.93 × 10<sup>-35</sup></td><td align="center" rowspan="1" colspan="1">1.30 (1.25-1.35)</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1">rs11209026</td><td align="left" rowspan="1" colspan="1">1p31</td><td align="left" rowspan="1" colspan="1">67.30-67.54</td><td align="center" rowspan="1" colspan="1">G</td><td align="center" rowspan="1" colspan="1">0.935</td><td align="center" rowspan="1" colspan="1">5.12 × 10<sup>-28</sup></td><td align="center" rowspan="1" colspan="1">1.74 (1.57-1.92)</td><td align="left" rowspan="1" colspan="1">CD, AS, BD, Ps</td><td align="left" rowspan="1" colspan="1"><bold><italic>IL23R</italic></bold></td></tr><tr><td align="left" rowspan="1" colspan="1">rs1801274</td><td align="left" rowspan="1" colspan="1">1q23</td><td align="left" rowspan="1" colspan="1">159.54-159.91</td><td align="center" rowspan="1" colspan="1">A</td><td align="center" rowspan="1" colspan="1">0.505</td><td align="center" rowspan="1" colspan="1">2.16 × 10<sup>-20</sup></td><td align="center" rowspan="1" colspan="1">1.21 (1.16-1.26)</td><td align="left" rowspan="1" colspan="1">SLE</td><td align="left" rowspan="1" colspan="1"><bold><italic>FCGR2A, FCGR2B, HSPA6</italic></bold></td></tr><tr><td align="left" rowspan="1" colspan="1">rs3024505</td><td align="left" rowspan="1" colspan="1">1q32</td><td align="left" rowspan="1" colspan="1">204.85-205.11</td><td align="center" rowspan="1" colspan="1">A</td><td align="center" rowspan="1" colspan="1">0.159</td><td align="center" rowspan="1" colspan="1">5.76 × 10<sup>-17</sup></td><td align="center" rowspan="1" colspan="1">1.25 (1.19-1.32)</td><td align="left" rowspan="1" colspan="1">CD, BD, SLE, T1D</td><td align="left" rowspan="1" colspan="1"><bold><italic>IL10, IL19</italic></bold></td></tr><tr><td align="left" rowspan="1" colspan="1">rs7608910</td><td align="left" rowspan="1" colspan="1">2p16</td><td align="left" rowspan="1" colspan="1">60.76-61.87</td><td align="center" rowspan="1" colspan="1">G</td><td align="center" rowspan="1" colspan="1">0.390</td><td align="center" rowspan="1" colspan="1">1.70 × 10<sup>-14</sup></td><td align="center" rowspan="1" colspan="1">1.19 (1.14-1.24)</td><td align="left" rowspan="1" colspan="1">CD, CeD, RA</td><td align="left" rowspan="1" colspan="1"><italic>PUS10</italic></td></tr><tr><td align="left" rowspan="1" colspan="1">rs4676406</td><td align="left" rowspan="1" colspan="1">2q37</td><td align="left" rowspan="1" colspan="1">241.20-241.32</td><td align="center" rowspan="1" colspan="1">T</td><td align="center" rowspan="1" colspan="1">0.516</td><td align="center" rowspan="1" colspan="1">8.32 × 10<sup>-11</sup></td><td align="center" rowspan="1" colspan="1">1.14 (1.09-1.18)</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"><bold><italic>GPR35</italic></bold></td></tr><tr><td align="left" rowspan="1" colspan="1">rs9822268</td><td align="left" rowspan="1" colspan="1">3p21</td><td align="left" rowspan="1" colspan="1">48.14-51.77</td><td align="center" rowspan="1" colspan="1">A</td><td align="center" rowspan="1" colspan="1">0.302</td><td align="center" rowspan="1" colspan="1">1.60 × 10<sup>-17</sup></td><td align="center" rowspan="1" colspan="1">1.21 (1.16-1.26)</td><td align="left" rowspan="1" colspan="1">CD</td><td align="left" rowspan="1" colspan="1"><bold>MST1, <italic>UBA7, APEH, AMIGO3, GMPPB, BSN</italic></bold></td></tr><tr><td align="left" rowspan="1" colspan="1">rs17388568</td><td align="left" rowspan="1" colspan="1">4q27</td><td align="left" rowspan="1" colspan="1">123.20-123.78</td><td align="center" rowspan="1" colspan="1">A</td><td align="center" rowspan="1" colspan="1">0.273</td><td align="center" rowspan="1" colspan="1">9.49 × 10<sup>-7</sup></td><td align="center" rowspan="1" colspan="1">1.12 (1.07-1.17)</td><td align="left" rowspan="1" colspan="1">CeD, T1D</td><td align="left" rowspan="1" colspan="1"><italic><bold>IL21, IL2</bold>, ADAD1</italic></td></tr><tr><td align="left" rowspan="1" colspan="1">rs11739663</td><td align="left" rowspan="1" colspan="1">5p15</td><td align="left" rowspan="1" colspan="1">0.48-0.80</td><td align="center" rowspan="1" colspan="1">T</td><td align="center" rowspan="1" colspan="1">0.767</td><td align="center" rowspan="1" colspan="1">2.80 × 10<sup>-8</sup></td><td align="center" rowspan="1" colspan="1">1.15 (1.09-1.21)</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"><bold><italic>EXOC3</italic></bold></td></tr><tr><td align="left" rowspan="1" colspan="1">rs9268853</td><td align="left" rowspan="1" colspan="1">6p21</td><td align="left" rowspan="1" colspan="1">31.49-33.01</td><td align="center" rowspan="1" colspan="1">T</td><td align="center" rowspan="1" colspan="1">0.661</td><td align="center" rowspan="1" colspan="1">1.35 × 10<sup>-55</sup></td><td align="center" rowspan="1" colspan="1">1.40 (1.34-1.47)</td><td align="left" rowspan="1" colspan="1">CD, CeD, GrD, MS, PBC, RA, T1D</td><td align="left" rowspan="1" colspan="1"><bold><italic>HLA-DRB5, HLA-DQA1, HLA-DRB1, HLA-DRA, BTNL2</italic></bold></td></tr><tr><td align="left" rowspan="1" colspan="1">rs4510766</td><td align="left" rowspan="1" colspan="1">7q22</td><td align="left" rowspan="1" colspan="1">107.20-107.39</td><td align="center" rowspan="1" colspan="1">A</td><td align="center" rowspan="1" colspan="1">0.559</td><td align="center" rowspan="1" colspan="1">2.00 × 10<sup>-16</sup></td><td align="center" rowspan="1" colspan="1">1.20 (1.15-1.26)</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1">rs6584283</td><td align="left" rowspan="1" colspan="1">10q24</td><td align="left" rowspan="1" colspan="1">101.25-101.33</td><td align="center" rowspan="1" colspan="1">T</td><td align="center" rowspan="1" colspan="1">0.472</td><td align="center" rowspan="1" colspan="1">8.46 × 10<sup>-21</sup></td><td align="center" rowspan="1" colspan="1">1.21 (1.16-1.26)</td><td align="left" rowspan="1" colspan="1">CD</td><td align="left" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1">rs7134599</td><td align="left" rowspan="1" colspan="1">12q14</td><td align="left" rowspan="1" colspan="1">66.72-66.92</td><td align="center" rowspan="1" colspan="1">A</td><td align="center" rowspan="1" colspan="1">0.385</td><td align="center" rowspan="1" colspan="1">1.06 × 10<sup>-16</sup></td><td align="center" rowspan="1" colspan="1">1.19 (1.14-1.24)</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"><bold><italic>IFNG, IL26</italic></bold></td></tr><tr><td align="left" rowspan="1" colspan="1">rs6499188</td><td align="left" rowspan="1" colspan="1">16q22</td><td align="left" rowspan="1" colspan="1">66.98-67.40</td><td align="center" rowspan="1" colspan="1">A</td><td align="center" rowspan="1" colspan="1">0.749</td><td align="center" rowspan="1" colspan="1">3.97 × 10<sup>-8</sup></td><td align="center" rowspan="1" colspan="1">1.14 (1.09-1.20)</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"><bold><italic>ZFP90</italic></bold></td></tr><tr><td align="left" rowspan="1" colspan="1">rs2872507</td><td align="left" rowspan="1" colspan="1">17q12</td><td align="left" rowspan="1" colspan="1">34.62-35.51</td><td align="center" rowspan="1" colspan="1">A</td><td align="center" rowspan="1" colspan="1">0.463</td><td align="center" rowspan="1" colspan="1">5.44 × 10<sup>-11</sup></td><td align="center" rowspan="1" colspan="1">1.15 (1.10-1.19)</td><td align="left" rowspan="1" colspan="1">CD, Ast, PBC, T1D, WBC</td><td align="left" rowspan="1" colspan="1"><bold><italic>IKZF3, ORMDL3, IKZF3, PNMT</italic>, ZPBP2, GSDML</bold></td></tr><tr><td align="left" rowspan="1" colspan="1">rs6017342</td><td align="left" rowspan="1" colspan="1">20q13</td><td align="left" rowspan="1" colspan="1">42.49-42.70</td><td align="center" rowspan="1" colspan="1">C</td><td align="center" rowspan="1" colspan="1">0.538</td><td align="center" rowspan="1" colspan="1">1.09 × 10<sup>-20</sup></td><td align="center" rowspan="1" colspan="1">1.20 (1.15-1.26)</td><td align="left" rowspan="1" colspan="1">HDL</td><td align="left" rowspan="1" colspan="1"><bold><italic>SERINC3</italic></bold></td></tr><tr><td align="left" rowspan="1" colspan="1">rs2836878</td><td align="left" rowspan="1" colspan="1">21q22</td><td align="left" rowspan="1" colspan="1">39.34-39.41</td><td align="center" rowspan="1" colspan="1">G</td><td align="center" rowspan="1" colspan="1">0.738</td><td align="center" rowspan="1" colspan="1">1.86 × 10<sup>-22</sup></td><td align="center" rowspan="1" colspan="1">1.25 (1.20-1.32)</td><td align="left" rowspan="1" colspan="1">AS</td><td align="left" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1">rs5771069</td><td align="left" rowspan="1" colspan="1">22q13</td><td align="left" rowspan="1" colspan="1">48.70-48.83</td><td align="center" rowspan="1" colspan="1">G</td><td align="center" rowspan="1" colspan="1">0.515</td><td align="center" rowspan="1" colspan="1">1.87 × 10<sup>-7</sup></td><td align="center" rowspan="1" colspan="1">1.11 (1.07-1.16)</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"><bold><italic>PIM3, IL17REL</italic></bold></td></tr></tbody></table></table-wrap><table-wrap id="T2" position="float" orientation="landscape"><label>Table 2</label><caption><title>Association results and <italic>in silico</italic> analyses for the 29 newly confirmed ulcerative colitis (UC) loci</title><p>UC loci that meet genome-wide significance P<5×10<sup>-8</sup> in the combined analysis and P<0.05 in the replication study. Left-right association boundaries are given for each index SNP (see <xref rid="SD2" ref-type="supplementary-material">Online Methods</xref>). RAF = risk allele frequency. OR is estimated using the replication cohort only. Known associations represent phenotypes previously associated with the locus at P<5×10<sup>-8</sup>. AtD = atopic dermatitis, BMD = bone mineral density, CD = Crohn’s disease, CeD = celiac disease, Gli = glioma, Lep = leprosy, MS = multiple sclerosis, MyN = myeloproliferative neoplasms, PBC = primary biliary sclerosis, Ps = psoriasis, RA = rheumatoid arthritis and SLE = systemic lupus erythematosus. Candidate genes of interest are listed. Those in bold were highlighted by <italic>in silico</italic> analyses (GRAIL connectivity and/or presence of an eQTL or nonsynonymous SNP. See <xref rid="SD2" ref-type="supplementary-material">Online Methods and Supplementary Table 7</xref> for more details).</p></caption><table frame="hsides" rules="groups"><thead><tr><th align="left" rowspan="1" colspan="1">dbSNP ID</th><th align="left" rowspan="1" colspan="1">Chr.</th><th align="left" rowspan="1" colspan="1">Left-right(Mb)</th><th align="center" rowspan="1" colspan="1">Risk Allele</th><th align="center" rowspan="1" colspan="1">Allele frequency in controls</th><th align="center" rowspan="1" colspan="1">P-value (meta)</th><th align="center" rowspan="1" colspan="1">P-value (follow-up)</th><th align="center" rowspan="1" colspan="1">P-value (comb)</th><th align="center" rowspan="1" colspan="1">OR (95% CI)</th><th align="left" rowspan="1" colspan="1">Association reported with other phenotypes</th><th align="left" rowspan="1" colspan="1">Positional candidate genes of interest</th></tr></thead><tbody><tr><td align="left" rowspan="1" colspan="1">rs734999</td><td align="left" rowspan="1" colspan="1">1p36</td><td align="left" rowspan="1" colspan="1">2.39-2.80</td><td align="center" rowspan="1" colspan="1">C</td><td align="center" rowspan="1" colspan="1">0.524</td><td align="center" rowspan="1" colspan="1">1.21 × 10<sup>-9</sup></td><td align="center" rowspan="1" colspan="1">1.51 × 10<sup>-2</sup></td><td align="center" rowspan="1" colspan="1">3.34 × 10<sup>-9</sup></td><td align="center" rowspan="1" colspan="1">1.05 (1.01-1.09)</td><td align="left" rowspan="1" colspan="1">CeD, PBC</td><td align="left" rowspan="1" colspan="1"><bold><italic>TNFRSF14, MMEL1, PLCH2, C1orf93</italic></bold></td></tr><tr><td align="left" rowspan="1" colspan="1">rs35675666</td><td align="left" rowspan="1" colspan="1">1p36</td><td align="left" rowspan="1" colspan="1">7.83-8.13</td><td align="center" rowspan="1" colspan="1">G</td><td align="center" rowspan="1" colspan="1">0.829</td><td align="center" rowspan="1" colspan="1">1.09 × 10<sup>-8</sup></td><td align="center" rowspan="1" colspan="1">1.13 × 10<sup>-2</sup></td><td align="center" rowspan="1" colspan="1">4.84 × 10<sup>-9</sup></td><td align="center" rowspan="1" colspan="1">1.08 (1.02-1.15)</td><td align="left" rowspan="1" colspan="1">CD</td><td align="left" rowspan="1" colspan="1"><italic><bold>TNFRSF9, ERFFI1,UTS2</bold>,PARK7</italic></td></tr><tr><td align="left" rowspan="1" colspan="1">rs7524102</td><td align="left" rowspan="1" colspan="1">1p36</td><td align="left" rowspan="1" colspan="1">22.54-22.61</td><td align="center" rowspan="1" colspan="1">A</td><td align="center" rowspan="1" colspan="1">0.828</td><td align="center" rowspan="1" colspan="1">1.04 × 10<sup>-11</sup></td><td align="center" rowspan="1" colspan="1">2.06 × 10<sup>-4</sup></td><td align="center" rowspan="1" colspan="1">1.65 × 10<sup>-13</sup></td><td align="center" rowspan="1" colspan="1">1.10 (1.05-1.16)</td><td align="left" rowspan="1" colspan="1">BMD</td><td align="left" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1">rs7554511</td><td align="left" rowspan="1" colspan="1">1q32</td><td align="left" rowspan="1" colspan="1">199.06-199.33</td><td align="center" rowspan="1" colspan="1">C</td><td align="center" rowspan="1" colspan="1">0.721</td><td align="center" rowspan="1" colspan="1">2.04 × 10<sup>-13</sup></td><td align="center" rowspan="1" colspan="1">NA</td><td align="center" rowspan="1" colspan="1">NA</td><td align="center" rowspan="1" colspan="1">1.19 (1.14-1.25)</td><td align="left" rowspan="1" colspan="1">CD, CeD</td><td align="left" rowspan="1" colspan="1"><italic>C1orf106</italic></td></tr><tr><td align="left" rowspan="1" colspan="1">rs2310173</td><td align="left" rowspan="1" colspan="1">2q11</td><td align="left" rowspan="1" colspan="1">101.66-102.13</td><td align="center" rowspan="1" colspan="1">T</td><td align="center" rowspan="1" colspan="1">0.461</td><td align="center" rowspan="1" colspan="1">8.44 × 10<sup>-8</sup></td><td align="center" rowspan="1" colspan="1">5.94 × 10<sup>-6</sup></td><td align="center" rowspan="1" colspan="1">3.17 × 10<sup>-12</sup></td><td align="center" rowspan="1" colspan="1">1.09 (1.05-1.14)</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"><bold><italic>IL1R2</italic></bold></td></tr><tr><td align="left" rowspan="1" colspan="1">rs11676348</td><td align="left" rowspan="1" colspan="1">2q35</td><td align="left" rowspan="1" colspan="1">218.58-218.97</td><td align="center" rowspan="1" colspan="1">T</td><td align="center" rowspan="1" colspan="1">0.486</td><td align="center" rowspan="1" colspan="1">8.78 × 10<sup>-9</sup></td><td align="center" rowspan="1" colspan="1">6.18 × 10<sup>-4</sup></td><td align="center" rowspan="1" colspan="1">1.25 × 10<sup>-10</sup></td><td align="center" rowspan="1" colspan="1">1.07 (1.03-1.11)</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"><bold><italic>IL8RA, SLC11A1, IL8RB, AAMP, ARPC</italic></bold></td></tr><tr><td align="left" rowspan="1" colspan="1">rs267939</td><td align="left" rowspan="1" colspan="1">5p15</td><td align="left" rowspan="1" colspan="1">10.72-10.90</td><td align="center" rowspan="1" colspan="1">C</td><td align="center" rowspan="1" colspan="1">0.368</td><td align="center" rowspan="1" colspan="1">9.67 × 10<sup>-7</sup></td><td align="center" rowspan="1" colspan="1">1.27 × 10<sup>-6</sup></td><td align="center" rowspan="1" colspan="1">6.01 × 10<sup>-12</sup></td><td align="center" rowspan="1" colspan="1">1.10 (1.06-1.15)</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"><bold><italic>DAP</italic></bold></td></tr><tr><td align="left" rowspan="1" colspan="1">rs3194051</td><td align="left" rowspan="1" colspan="1">5p13</td><td align="left" rowspan="1" colspan="1">35.83-36.07</td><td align="center" rowspan="1" colspan="1">G</td><td align="center" rowspan="1" colspan="1">0.269</td><td align="center" rowspan="1" colspan="1">2.19 × 10<sup>-6</sup></td><td align="center" rowspan="1" colspan="1">2.06 × 10<sup>-3</sup></td><td align="center" rowspan="1" colspan="1">4.22 × 10<sup>-8</sup></td><td align="center" rowspan="1" colspan="1">1.07 (1.02-1.12)</td><td align="left" rowspan="1" colspan="1">MS</td><td align="left" rowspan="1" colspan="1"><bold><italic>IL7R</italic></bold></td></tr><tr><td align="left" rowspan="1" colspan="1">rs6451493*</td><td align="left" rowspan="1" colspan="1">5p13</td><td align="left" rowspan="1" colspan="1">40.32-40.85</td><td align="center" rowspan="1" colspan="1">T</td><td align="center" rowspan="1" colspan="1">0.610</td><td align="center" rowspan="1" colspan="1">1.78 × 10<sup>-6</sup></td><td align="center" rowspan="1" colspan="1">2.09 × 10<sup>-4</sup></td><td align="center" rowspan="1" colspan="1">2.80 × 10<sup>-9</sup></td><td align="center" rowspan="1" colspan="1">1.08 (1.04-1.12)</td><td align="left" rowspan="1" colspan="1">CD, MS</td><td align="left" rowspan="1" colspan="1"><bold><italic>PTGER4</italic></bold></td></tr><tr><td align="left" rowspan="1" colspan="1">rs254560</td><td align="left" rowspan="1" colspan="1">5q31</td><td align="left" rowspan="1" colspan="1">134.41-134.53</td><td align="center" rowspan="1" colspan="1">A</td><td align="center" rowspan="1" colspan="1">0.397</td><td align="center" rowspan="1" colspan="1">3.06 × 10<sup>-7</sup></td><td align="center" rowspan="1" colspan="1">4.19 × 10<sup>-4</sup></td><td align="center" rowspan="1" colspan="1">1.25 × 10<sup>-9</sup></td><td align="center" rowspan="1" colspan="1">1.07 (1.03-1.12)</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1">rs6871626</td><td align="left" rowspan="1" colspan="1">5q33</td><td align="left" rowspan="1" colspan="1">158.46-158.86</td><td align="center" rowspan="1" colspan="1">A</td><td align="center" rowspan="1" colspan="1">0.334</td><td align="center" rowspan="1" colspan="1">1.02 × 10<sup>-8</sup></td><td align="center" rowspan="1" colspan="1">1.40 × 10<sup>-14</sup></td><td align="center" rowspan="1" colspan="1">1.11 × 10<sup>-21</sup></td><td align="center" rowspan="1" colspan="1">1.17 (1.12-1.22)</td><td align="left" rowspan="1" colspan="1">CD, Ps, SLE</td><td align="left" rowspan="1" colspan="1"><bold><italic>IL12B</italic></bold></td></tr><tr><td align="left" rowspan="1" colspan="1">rs943072</td><td align="left" rowspan="1" colspan="1">6p21</td><td align="left" rowspan="1" colspan="1">43.88-43.92</td><td align="center" rowspan="1" colspan="1">G</td><td align="center" rowspan="1" colspan="1">0.092</td><td align="center" rowspan="1" colspan="1">1.05 × 10<sup>-6</sup></td><td align="center" rowspan="1" colspan="1">3.71 × 10<sup>-5</sup></td><td align="center" rowspan="1" colspan="1">2.37 × 10<sup>-10</sup></td><td align="center" rowspan="1" colspan="1">1.15 (1.08-1.23)</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1">rs6911490</td><td align="left" rowspan="1" colspan="1">6q21</td><td align="left" rowspan="1" colspan="1">106.51-106.67</td><td align="center" rowspan="1" colspan="1">T</td><td align="center" rowspan="1" colspan="1">0.210</td><td align="center" rowspan="1" colspan="1">3.51 × 10<sup>-7</sup></td><td align="center" rowspan="1" colspan="1">1.70 × 10<sup>-3</sup></td><td align="center" rowspan="1" colspan="1">1.01 × 10<sup>-8</sup></td><td align="center" rowspan="1" colspan="1">1.08 (1.03-1.13)</td><td align="left" rowspan="1" colspan="1">CD, RA, SLE</td><td align="left" rowspan="1" colspan="1"><bold><italic>PDRM1</italic></bold></td></tr><tr><td align="left" rowspan="1" colspan="1">rs6920220</td><td align="left" rowspan="1" colspan="1">6q23</td><td align="left" rowspan="1" colspan="1">137.88-138.17</td><td align="center" rowspan="1" colspan="1">A</td><td align="center" rowspan="1" colspan="1">0.207</td><td align="center" rowspan="1" colspan="1">6.38 × 10<sup>-10</sup></td><td align="center" rowspan="1" colspan="1">1.94 × 10<sup>-8</sup></td><td align="center" rowspan="1" colspan="1">8.05 × 10<sup>-17</sup></td><td align="center" rowspan="1" colspan="1">1.14 (1.09-1.20)</td><td align="left" rowspan="1" colspan="1">CeD, Ps, RA, SLE</td><td align="left" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1">rs798502</td><td align="left" rowspan="1" colspan="1">7p22</td><td align="left" rowspan="1" colspan="1">2.70-2.90</td><td align="center" rowspan="1" colspan="1">A</td><td align="center" rowspan="1" colspan="1">0.711</td><td align="center" rowspan="1" colspan="1">1.21 × 10<sup>-8</sup></td><td align="center" rowspan="1" colspan="1">3.82 × 10<sup>-8</sup></td><td align="center" rowspan="1" colspan="1">2.61 × 10<sup>-15</sup></td><td align="center" rowspan="1" colspan="1">1.13 (1.08-1.18)</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"><bold><italic>GNA12</italic></bold></td></tr><tr><td align="left" rowspan="1" colspan="1">rs4728142</td><td align="left" rowspan="1" colspan="1">7q32</td><td align="left" rowspan="1" colspan="1">128.33-128.56</td><td align="center" rowspan="1" colspan="1">A</td><td align="center" rowspan="1" colspan="1">0.444</td><td align="center" rowspan="1" colspan="1">1.68 × 10<sup>-6</sup></td><td align="center" rowspan="1" colspan="1">1.25 × 10<sup>-3</sup></td><td align="center" rowspan="1" colspan="1">1.74 × 10<sup>-8</sup></td><td align="center" rowspan="1" colspan="1">1.07 (1.03-1.11)</td><td align="left" rowspan="1" colspan="1">SLE, RA, PBC</td><td align="left" rowspan="1" colspan="1"><bold><italic>IRF5, TNPO3</italic></bold></td></tr><tr><td align="left" rowspan="1" colspan="1">rs10758669</td><td align="left" rowspan="1" colspan="1">9p24</td><td align="left" rowspan="1" colspan="1">4.93-5.28</td><td align="center" rowspan="1" colspan="1">C</td><td align="center" rowspan="1" colspan="1">0.350</td><td align="center" rowspan="1" colspan="1">8.52 × 10<sup>-13</sup></td><td align="center" rowspan="1" colspan="1">3.78 × 10<sup>-14</sup></td><td align="center" rowspan="1" colspan="1">2.22 × 10<sup>-25</sup></td><td align="center" rowspan="1" colspan="1">1.17 (1.12-1.21)</td><td align="left" rowspan="1" colspan="1">CD, MyN</td><td align="left" rowspan="1" colspan="1"><bold><italic>JAK2</italic></bold></td></tr><tr><td align="left" rowspan="1" colspan="1">rs4246905</td><td align="left" rowspan="1" colspan="1">9q32</td><td align="left" rowspan="1" colspan="1">116.48-116.74</td><td align="center" rowspan="1" colspan="1">C</td><td align="center" rowspan="1" colspan="1">0.713</td><td align="center" rowspan="1" colspan="1">4.77 × 10<sup>-8</sup></td><td align="center" rowspan="1" colspan="1">1.44 × 10<sup>-5</sup></td><td align="center" rowspan="1" colspan="1">5.65 × 10<sup>-12</sup></td><td align="center" rowspan="1" colspan="1">1.10 (1.05-1.15)</td><td align="left" rowspan="1" colspan="1">CD, Lep</td><td align="left" rowspan="1" colspan="1"><bold><italic>TNFSF8, TNFSF15</italic></bold></td></tr><tr><td align="left" rowspan="1" colspan="1">rs10781499</td><td align="left" rowspan="1" colspan="1">9q34</td><td align="left" rowspan="1" colspan="1">138.27-138.55</td><td align="center" rowspan="1" colspan="1">A</td><td align="center" rowspan="1" colspan="1">0.411</td><td align="center" rowspan="1" colspan="1">6.95 × 10<sup>-13</sup></td><td align="center" rowspan="1" colspan="1">2.50 × 10<sup>-8</sup></td><td align="center" rowspan="1" colspan="1">2.62 × 10<sup>-19</sup></td><td align="center" rowspan="1" colspan="1">1.12 (1.08-1.17)</td><td align="left" rowspan="1" colspan="1">CD</td><td align="left" rowspan="1" colspan="1"><bold><italic>CARD9, INPP5E, SDCCAG3, SEC16A, SNAPC4</italic></bold></td></tr><tr><td align="left" rowspan="1" colspan="1">rs12261843</td><td align="left" rowspan="1" colspan="1">10p11</td><td align="left" rowspan="1" colspan="1">35.22-35.94</td><td align="center" rowspan="1" colspan="1">G</td><td align="center" rowspan="1" colspan="1">0.286</td><td align="center" rowspan="1" colspan="1">2.35 × 10<sup>-8</sup></td><td align="center" rowspan="1" colspan="1">1.22 × 10<sup>-3</sup></td><td align="center" rowspan="1" colspan="1">7.09 × 10<sup>-10</sup></td><td align="center" rowspan="1" colspan="1">1.07 (1.03-1.12)</td><td align="left" rowspan="1" colspan="1">CD</td><td align="left" rowspan="1" colspan="1"><bold><italic>CCNY</italic></bold></td></tr><tr><td align="left" rowspan="1" colspan="1">rs907611</td><td align="left" rowspan="1" colspan="1">11q15</td><td align="left" rowspan="1" colspan="1">1.82-1.93</td><td align="center" rowspan="1" colspan="1">A</td><td align="center" rowspan="1" colspan="1">0.317</td><td align="center" rowspan="1" colspan="1">2.49 × 10<sup>-8</sup></td><td align="center" rowspan="1" colspan="1">3.58 × 10<sup>-4</sup></td><td align="center" rowspan="1" colspan="1">1.38 × 10<sup>-10</sup></td><td align="center" rowspan="1" colspan="1">1.08 (1.03-1.13)</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"><bold><italic>LSP1</italic></bold></td></tr><tr><td align="left" rowspan="1" colspan="1">rs2155219</td><td align="left" rowspan="1" colspan="1">11q13</td><td align="left" rowspan="1" colspan="1">75.72-76.02</td><td align="center" rowspan="1" colspan="1">T</td><td align="center" rowspan="1" colspan="1">0.500</td><td align="center" rowspan="1" colspan="1">6.33 × 10<sup>-8</sup></td><td align="center" rowspan="1" colspan="1">1.61 × 10<sup>-9</sup></td><td align="center" rowspan="1" colspan="1">5.39 × 10<sup>-16</sup></td><td align="center" rowspan="1" colspan="1">1.13 (1.08-1.17)</td><td align="left" rowspan="1" colspan="1">CD, AtD</td><td align="left" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1">rs678170</td><td align="left" rowspan="1" colspan="1">11q23</td><td align="left" rowspan="1" colspan="1">113.76-114.08</td><td align="center" rowspan="1" colspan="1">A</td><td align="center" rowspan="1" colspan="1">0.661</td><td align="center" rowspan="1" colspan="1">6.88 × 10<sup>-11</sup></td><td align="center" rowspan="1" colspan="1">2.50 × 10<sup>-5</sup></td><td align="center" rowspan="1" colspan="1">4.65 × 10<sup>-14</sup></td><td align="center" rowspan="1" colspan="1">1.09 (1.05-1.14)</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1">rs17085007</td><td align="left" rowspan="1" colspan="1">13q12</td><td align="left" rowspan="1" colspan="1">26.39-26.46</td><td align="center" rowspan="1" colspan="1">C</td><td align="center" rowspan="1" colspan="1">0.178</td><td align="center" rowspan="1" colspan="1">3.30 × 10<sup>-9</sup></td><td align="center" rowspan="1" colspan="1">4.66 × 10<sup>-9</sup></td><td align="center" rowspan="1" colspan="1">9.65 × 10<sup>-17</sup></td><td align="center" rowspan="1" colspan="1">1.16 (1.10-1.21)</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1">rs941823</td><td align="left" rowspan="1" colspan="1">13q13</td><td align="left" rowspan="1" colspan="1">39.90-39.95</td><td align="center" rowspan="1" colspan="1">C</td><td align="center" rowspan="1" colspan="1">0.756</td><td align="center" rowspan="1" colspan="1">3.93 × 10<sup>-7</sup></td><td align="center" rowspan="1" colspan="1">1.93 × 10<sup>-6</sup></td><td align="center" rowspan="1" colspan="1">3.82 × 10<sup>-12</sup></td><td align="center" rowspan="1" colspan="1">1.12 (1.07-1.17)</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1">rs16940202</td><td align="left" rowspan="1" colspan="1">16q24</td><td align="left" rowspan="1" colspan="1">84.53-84.58</td><td align="center" rowspan="1" colspan="1">C</td><td align="center" rowspan="1" colspan="1">0.180</td><td align="center" rowspan="1" colspan="1">1.27 × 10<sup>-12</sup></td><td align="center" rowspan="1" colspan="1">1.42 × 10<sup>-8</sup></td><td align="center" rowspan="1" colspan="1">5.96 × 10<sup>-19</sup></td><td align="center" rowspan="1" colspan="1">1.15 (1.10-1.21)</td><td align="left" rowspan="1" colspan="1">MS</td><td align="left" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1">rs2297441</td><td align="left" rowspan="1" colspan="1">20q13</td><td align="left" rowspan="1" colspan="1">61.66-61.98</td><td align="center" rowspan="1" colspan="1">A</td><td align="center" rowspan="1" colspan="1">0.766</td><td align="center" rowspan="1" colspan="1">5.78 × 10<sup>-8</sup></td><td align="center" rowspan="1" colspan="1">2.68 × 10<sup>-4</sup></td><td align="center" rowspan="1" colspan="1">1.70 × 10<sup>-10</sup></td><td align="center" rowspan="1" colspan="1">1.09 (1.04-1.15)</td><td align="left" rowspan="1" colspan="1">CD, Gli</td><td align="left" rowspan="1" colspan="1"><bold><italic>SLC2A4RG, STMN3, ZBTB46, ZGPAT, RTEL1, TNFRSF6B</italic></bold></td></tr><tr><td align="left" rowspan="1" colspan="1">rs1297265</td><td align="left" rowspan="1" colspan="1">21q21</td><td align="left" rowspan="1" colspan="1">15.62-15.77</td><td align="center" rowspan="1" colspan="1">A</td><td align="center" rowspan="1" colspan="1">0.564</td><td align="center" rowspan="1" colspan="1">1.73 × 10<sup>-7</sup></td><td align="center" rowspan="1" colspan="1">5.02 × 10<sup>-7</sup></td><td align="center" rowspan="1" colspan="1">6.99 × 10<sup>-13</sup></td><td align="center" rowspan="1" colspan="1">1.11 (1.06-1.15)</td><td align="left" rowspan="1" colspan="1">CD</td><td align="left" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1">rs2838519</td><td align="left" rowspan="1" colspan="1">21q22</td><td align="left" rowspan="1" colspan="1">44.41-44.52</td><td align="center" rowspan="1" colspan="1">G</td><td align="center" rowspan="1" colspan="1">0.390</td><td align="center" rowspan="1" colspan="1">2.26 × 10<sup>-8</sup></td><td align="center" rowspan="1" colspan="1">7.10 × 10<sup>-4</sup></td><td align="center" rowspan="1" colspan="1">6.41 × 10<sup>-11</sup></td><td align="center" rowspan="1" colspan="1">1.14 (1.05-1.22)</td><td align="left" rowspan="1" colspan="1">CD</td><td align="left" rowspan="1" colspan="1"><bold><italic>ICOSLG</italic></bold></td></tr></tbody></table></table-wrap><table-wrap id="T3" position="float" orientation="landscape"><label>Table 3</label><caption><title>Shared association signals between UC and CD</title><p>A shared association is defined as a confirmed association (P<sub>combined</sub> < 5×10<sup>-8</sup>) in either UC or CD and P<sub>meta</sub> < 1×10-4 in the other form of IBD. For more details and comparative results across all 99 reported IBD risk loci see <xref rid="SD2" ref-type="supplementary-material">Supplementary table 9</xref>.</p></caption><table frame="box" rules="groups"><thead><tr><th align="center" colspan="2" valign="bottom" rowspan="1">LOCUS</th><th align="center" valign="bottom" rowspan="1" colspan="1">GENE</th><th align="center" colspan="3" valign="bottom" rowspan="1">INDEX SNP</th><th align="center" colspan="2" valign="bottom" rowspan="1">CD-META (6333/15056)</th><th align="center" colspan="2" valign="bottom" rowspan="1">UC-META (6687/19718)</th></tr><tr><th align="center" rowspan="1" colspan="1">Chr.</th><th align="center" rowspan="1" colspan="1">Left-Right (Mb)</th><th align="center" rowspan="1" colspan="1">Candidate</th><th align="center" rowspan="1" colspan="1">SNP</th><th align="center" rowspan="1" colspan="1">Risk Allele</th><th align="center" rowspan="1" colspan="1">Allele frequency in controls</th><th align="center" rowspan="1" colspan="1">p-value</th><th align="center" rowspan="1" colspan="1">OR (95% CI)</th><th align="center" rowspan="1" colspan="1">p-value</th><th align="center" rowspan="1" colspan="1">OR (95% CI)</th></tr></thead><tbody><tr><td align="center" rowspan="1" colspan="1">1p31</td><td align="center" rowspan="1" colspan="1">67.30-67.54</td><td align="center" rowspan="1" colspan="1"><italic>IL23R</italic></td><td align="center" rowspan="1" colspan="1">rs11209026</td><td align="center" rowspan="1" colspan="1">G</td><td align="center" rowspan="1" colspan="1">0.94</td><td align="center" rowspan="1" colspan="1">1.00×10<sup>-64</sup></td><td align="center" rowspan="1" colspan="1">2.67 (2.37-3.01)</td><td align="center" rowspan="1" colspan="1">5.12×10<sup>-28</sup></td><td align="center" rowspan="1" colspan="1">1.74 (1.57-1.92)</td></tr><tr><td align="left" colspan="10" valign="bottom" rowspan="1"><hr></hr></td></tr><tr><td align="center" rowspan="1" colspan="1">1q32</td><td align="center" rowspan="1" colspan="1">199.0 -199.33</td><td align="center" rowspan="1" colspan="1"><italic>KIF21B</italic></td><td align="center" rowspan="1" colspan="1">rs7554511</td><td align="center" rowspan="1" colspan="1">C</td><td align="center" rowspan="1" colspan="1">0.72</td><td align="center" rowspan="1" colspan="1">1.58×10<sup>-7</sup></td><td align="center" rowspan="1" colspan="1">1.14 (1.08-1.19)</td><td align="center" rowspan="1" colspan="1">2.04×10<sup>-13</sup></td><td align="center" rowspan="1" colspan="1">1.19 (1.14-1.25)</td></tr><tr><td align="left" colspan="10" valign="bottom" rowspan="1"><hr></hr></td></tr><tr><td align="center" rowspan="1" colspan="1">1q32</td><td align="center" rowspan="1" colspan="1">204.85-205.11</td><td align="center" rowspan="1" colspan="1"><italic>IL10</italic></td><td align="center" rowspan="1" colspan="1">rs3024505</td><td align="center" rowspan="1" colspan="1">A</td><td align="center" rowspan="1" colspan="1">0.16</td><td align="center" rowspan="1" colspan="1">8.32×10<sup>-9</sup></td><td align="center" rowspan="1" colspan="1">1.18 (1.12-1.25)</td><td align="center" rowspan="1" colspan="1">5.76×10<sup>-17</sup></td><td align="center" rowspan="1" colspan="1">1.25 (1.19-1.32)</td></tr><tr><td align="left" colspan="10" valign="bottom" rowspan="1"><hr></hr></td></tr><tr><td align="center" rowspan="1" colspan="1">2p16</td><td align="center" rowspan="1" colspan="1">60.76-61.87</td><td align="center" rowspan="1" colspan="1"><italic>REL</italic></td><td align="center" rowspan="1" colspan="1">rs7608910</td><td align="center" rowspan="1" colspan="1">G</td><td align="center" rowspan="1" colspan="1">0.39</td><td align="center" rowspan="1" colspan="1">3.11×10<sup>-7</sup></td><td align="center" rowspan="1" colspan="1">1.14 (1.09-1.21)</td><td align="center" rowspan="1" colspan="1">1.70×10<sup>-14</sup></td><td align="center" rowspan="1" colspan="1">1.19 (1.14-1.24)</td></tr><tr><td align="left" colspan="10" valign="bottom" rowspan="1"><hr></hr></td></tr><tr><td align="center" rowspan="1" colspan="1">2q11</td><td align="center" rowspan="1" colspan="1">101.66-102.13</td><td align="center" rowspan="1" colspan="1"><italic>IL1R2</italic></td><td align="center" rowspan="1" colspan="1">rs2310173</td><td align="center" rowspan="1" colspan="1">T</td><td align="center" rowspan="1" colspan="1">0.46</td><td align="center" rowspan="1" colspan="1">8.31×10<sup>-5</sup></td><td align="center" rowspan="1" colspan="1">1.09 (1.04-1.14)</td><td align="center" rowspan="1" colspan="1">8.44×10<sup>-8</sup></td><td align="center" rowspan="1" colspan="1">1.12 (1.07-1.16)</td></tr><tr><td align="left" colspan="10" valign="bottom" rowspan="1"><hr></hr></td></tr><tr><td align="center" rowspan="1" colspan="1">3p21</td><td align="center" rowspan="1" colspan="1">48.14-51.77</td><td align="center" rowspan="1" colspan="1"><italic>MST1</italic></td><td align="center" rowspan="1" colspan="1">rs3197999</td><td align="center" rowspan="1" colspan="1">A</td><td align="center" rowspan="1" colspan="1">0.30</td><td align="center" rowspan="1" colspan="1">6.17×10<sup>-17</sup></td><td align="center" rowspan="1" colspan="1">1.22 (1.16-1.27)</td><td align="center" rowspan="1" colspan="1">1.86×10<sup>-17</sup></td><td align="center" rowspan="1" colspan="1">1.21 (1.16-1.26)</td></tr><tr><td align="left" colspan="10" valign="bottom" rowspan="1"><hr></hr></td></tr><tr><td align="center" rowspan="1" colspan="1">5p13</td><td align="center" rowspan="1" colspan="1">40.32-40.85</td><td align="center" rowspan="1" colspan="1"><italic>PTGER4</italic></td><td align="center" rowspan="1" colspan="1">rs6451493</td><td align="center" rowspan="1" colspan="1">T</td><td align="center" rowspan="1" colspan="1">0.61</td><td align="center" rowspan="1" colspan="1">1.61×10<sup>-27</sup></td><td align="center" rowspan="1" colspan="1">1.35 (1.28-1.43)</td><td align="center" rowspan="1" colspan="1">1.78×10<sup>-6</sup></td><td align="center" rowspan="1" colspan="1">1.12 (1.07-1.17)</td></tr><tr><td align="left" colspan="10" valign="bottom" rowspan="1"><hr></hr></td></tr><tr><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"><italic>IL12B</italic></td><td align="center" rowspan="1" colspan="1">rs6871626</td><td align="center" rowspan="1" colspan="1">A</td><td align="center" rowspan="1" colspan="1">0.33</td><td align="center" rowspan="1" colspan="1">6.08×10<sup>-12</sup></td><td align="center" rowspan="1" colspan="1">1.15 (1.10-1.20)</td><td align="center" rowspan="1" colspan="1">1.02×10<sup>-8</sup></td><td align="center" rowspan="1" colspan="1">1.12 (1.08-1.17)</td></tr><tr><td align="center" rowspan="1" colspan="1">5q33</td><td align="center" rowspan="1" colspan="1">158.46-158.86</td><td align="center" rowspan="1" colspan="1"><italic>IL12B</italic></td><td align="center" rowspan="1" colspan="1">rs6556412 (r<sup>2</sup>=0.03)</td><td align="center" rowspan="1" colspan="1">A</td><td align="center" rowspan="1" colspan="1">0.34</td><td align="center" rowspan="1" colspan="1">5.37×10<sup>-14</sup></td><td align="center" rowspan="1" colspan="1">1.18 (1.13-1.23)</td><td align="center" rowspan="1" colspan="1">1.69×10<sup>-5</sup></td><td align="center" rowspan="1" colspan="1">1.09 (1.05-1.14)</td></tr><tr><td align="left" colspan="10" valign="bottom" rowspan="1"><hr></hr></td></tr><tr><td align="center" rowspan="1" colspan="1">6p22</td><td align="center" rowspan="1" colspan="1">20.60-21.25</td><td align="center" rowspan="1" colspan="1"><italic>CDKAL1</italic></td><td align="center" rowspan="1" colspan="1">rs6908425</td><td align="center" rowspan="1" colspan="1">C</td><td align="center" rowspan="1" colspan="1">0.78</td><td align="center" rowspan="1" colspan="1">1.41×10<sup>-8</sup></td><td align="center" rowspan="1" colspan="1">1.17 (1.11-1.23)</td><td align="center" rowspan="1" colspan="1">7.75×10<sup>-5</sup></td><td align="center" rowspan="1" colspan="1">1.11 (1.05-1.16)</td></tr><tr><td align="left" colspan="10" valign="bottom" rowspan="1"><hr></hr></td></tr><tr><td align="center" rowspan="1" colspan="1">6q21</td><td align="center" rowspan="1" colspan="1">106.51-106.67</td><td align="center" rowspan="1" colspan="1"><italic>PRDM1</italic></td><td align="center" rowspan="1" colspan="1">rs6911490</td><td align="center" rowspan="1" colspan="1">T</td><td align="center" rowspan="1" colspan="1">0.21</td><td align="center" rowspan="1" colspan="1">4.28×10<sup>-7</sup></td><td align="center" rowspan="1" colspan="1">1.12 (1.07-1.18)</td><td align="center" rowspan="1" colspan="1">3.51×10<sup>-7</sup></td><td align="center" rowspan="1" colspan="1">1.13 (1.07-1.18)</td></tr><tr><td align="left" colspan="10" valign="bottom" rowspan="1"><hr></hr></td></tr><tr><td align="center" rowspan="1" colspan="1">9p24</td><td align="center" rowspan="1" colspan="1">4.93-5.29</td><td align="center" rowspan="1" colspan="1"><italic>JAK2</italic></td><td align="center" rowspan="1" colspan="1">rs10758669</td><td align="center" rowspan="1" colspan="1">C</td><td align="center" rowspan="1" colspan="1">0.35</td><td align="center" rowspan="1" colspan="1">1.00×10<sup>-13</sup></td><td align="center" rowspan="1" colspan="1">1.18 (1.13-1.23)</td><td align="center" rowspan="1" colspan="1">8.52×10<sup>-13</sup></td><td align="center" rowspan="1" colspan="1">1.16 (1.11-1.21)</td></tr><tr><td align="left" colspan="10" valign="bottom" rowspan="1"><hr></hr></td></tr><tr><td align="center" rowspan="1" colspan="1">9q32</td><td align="center" rowspan="1" colspan="1">116.48-116.74</td><td align="center" rowspan="1" colspan="1"><italic>TNFSF15</italic></td><td align="center" rowspan="1" colspan="1">rs4246905</td><td align="center" rowspan="1" colspan="1">C</td><td align="center" rowspan="1" colspan="1">0.71</td><td align="center" rowspan="1" colspan="1">1.33×10<sup>-15</sup></td><td align="center" rowspan="1" colspan="1">1.21 (1.15-1.28)</td><td align="center" rowspan="1" colspan="1">4.77×10<sup>-8</sup></td><td align="center" rowspan="1" colspan="1">1.13 (1.08-1.18)</td></tr><tr><td align="left" colspan="10" valign="bottom" rowspan="1"><hr></hr></td></tr><tr><td align="center" rowspan="1" colspan="1">9q34</td><td align="center" rowspan="1" colspan="1">138.27-138.55</td><td align="center" rowspan="1" colspan="1"><italic>CARD9</italic></td><td align="center" rowspan="1" colspan="1">rs10781499</td><td align="center" rowspan="1" colspan="1">A</td><td align="center" rowspan="1" colspan="1">0.40</td><td align="center" rowspan="1" colspan="1">3.49×10<sup>-18</sup></td><td align="center" rowspan="1" colspan="1">1.20 (1.15-1.26)</td><td align="center" rowspan="1" colspan="1">6.95×10<sup>-13</sup></td><td align="center" rowspan="1" colspan="1">1.16 (1.11-1.21)</td></tr><tr><td align="left" colspan="10" valign="bottom" rowspan="1"><hr></hr></td></tr><tr><td align="center" rowspan="1" colspan="1">10p11</td><td align="center" rowspan="1" colspan="1">35.22-35.94</td><td align="center" rowspan="1" colspan="1"><italic>CREM/CCNY</italic></td><td align="center" rowspan="1" colspan="1">rs12261843</td><td align="center" rowspan="1" colspan="1">G</td><td align="center" rowspan="1" colspan="1">0.29</td><td align="center" rowspan="1" colspan="1">1.87×10<sup>-9</sup></td><td align="center" rowspan="1" colspan="1">1.15 (1.10-1.20)</td><td align="center" rowspan="1" colspan="1">2.35×10<sup>-8</sup></td><td align="center" rowspan="1" colspan="1">1.13 (1.08-1.18)</td></tr><tr><td align="left" colspan="10" valign="bottom" rowspan="1"><hr></hr></td></tr><tr><td align="center" rowspan="1" colspan="1">10q21</td><td align="center" rowspan="1" colspan="1">63.97-64.43</td><td align="center" rowspan="1" colspan="1"><italic>ZNF365</italic></td><td align="center" rowspan="1" colspan="1">rs10761659</td><td align="center" rowspan="1" colspan="1">G</td><td align="center" rowspan="1" colspan="1">0.54</td><td align="center" rowspan="1" colspan="1">4.37×10<sup>-22</sup></td><td align="center" rowspan="1" colspan="1">1.23 (1.18-1.28)</td><td align="center" rowspan="1" colspan="1">7.39×10<sup>-6</sup></td><td align="center" rowspan="1" colspan="1">1.10 (1.05-1.14)</td></tr><tr><td align="left" colspan="10" valign="bottom" rowspan="1"><hr></hr></td></tr><tr><td align="center" rowspan="1" colspan="1">10q24</td><td align="center" rowspan="1" colspan="1">101.25-101.33</td><td align="center" rowspan="1" colspan="1"><italic>NKX2.3</italic></td><td align="center" rowspan="1" colspan="1">rs6584283</td><td align="center" rowspan="1" colspan="1">T</td><td align="center" rowspan="1" colspan="1">0.47</td><td align="center" rowspan="1" colspan="1">7.18×10<sup>-20</sup></td><td align="center" rowspan="1" colspan="1">1.21 (1.16-1.27)</td><td align="center" rowspan="1" colspan="1">8.46×10<sup>-21</sup></td><td align="center" rowspan="1" colspan="1">1.21 (1.16-1.26)</td></tr><tr><td align="left" colspan="10" valign="bottom" rowspan="1"><hr></hr></td></tr><tr><td align="center" rowspan="1" colspan="1">11q13</td><td align="center" rowspan="1" colspan="1">75.72-76.02</td><td align="center" rowspan="1" colspan="1"><italic>C11Orf30</italic></td><td align="center" rowspan="1" colspan="1">rs2155219</td><td align="center" rowspan="1" colspan="1">T</td><td align="center" rowspan="1" colspan="1">0.50</td><td align="center" rowspan="1" colspan="1">1.58×10<sup>-12</sup></td><td align="center" rowspan="1" colspan="1">1.16 (1.11-1.21)</td><td align="center" rowspan="1" colspan="1">6.33×10<sup>-8</sup></td><td align="center" rowspan="1" colspan="1">1.12 (1.07-1.16)</td></tr><tr><td align="left" colspan="10" valign="bottom" rowspan="1"><hr></hr></td></tr><tr><td align="center" rowspan="1" colspan="1">15q22</td><td align="center" rowspan="1" colspan="1">65.2-65.27</td><td align="center" rowspan="1" colspan="1"><italic>SMAD3</italic></td><td align="center" rowspan="1" colspan="1">rs17293632</td><td align="center" rowspan="1" colspan="1">T</td><td align="center" rowspan="1" colspan="1">0.24</td><td align="center" rowspan="1" colspan="1">1.41×10<sup>-13</sup></td><td align="center" rowspan="1" colspan="1">1.19 (1.14-1.25)</td><td align="center" rowspan="1" colspan="1">9.52×10<sup>-6</sup></td><td align="center" rowspan="1" colspan="1">1.11 (1.06-1.16)</td></tr><tr><td align="left" colspan="10" valign="bottom" rowspan="1"><hr></hr></td></tr><tr><td align="center" rowspan="1" colspan="1">17q12</td><td align="center" rowspan="1" colspan="1">34.62-35.51</td><td align="center" rowspan="1" colspan="1"><italic>ORMDL3</italic></td><td align="center" rowspan="1" colspan="1">rs2872507</td><td align="center" rowspan="1" colspan="1">A</td><td align="center" rowspan="1" colspan="1">0.46</td><td align="center" rowspan="1" colspan="1">1.51×10<sup>-9</sup></td><td align="center" rowspan="1" colspan="1">1.14 (1.09-1.19)</td><td align="center" rowspan="1" colspan="1">5.44×10<sup>-11</sup></td><td align="center" rowspan="1" colspan="1">1.15 (1.10-1.19)</td></tr><tr><td align="left" colspan="10" valign="bottom" rowspan="1"><hr></hr></td></tr><tr><td align="center" rowspan="1" colspan="1">18p11</td><td align="center" rowspan="1" colspan="1">12.73-12.92</td><td align="center" rowspan="1" colspan="1"><italic>PTPN2</italic></td><td align="center" rowspan="1" colspan="1">rs1893217</td><td align="center" rowspan="1" colspan="1">G</td><td align="center" rowspan="1" colspan="1">0.16</td><td align="center" rowspan="1" colspan="1">1.29×10<sup>-14</sup></td><td align="center" rowspan="1" colspan="1">1.25 (1.18-1.32)</td><td align="center" rowspan="1" colspan="1">4.78×10<sup>-5</sup></td><td align="center" rowspan="1" colspan="1">1.12 (1.06-1.18)</td></tr><tr><td align="left" colspan="10" valign="bottom" rowspan="1"><hr></hr></td></tr><tr><td align="center" rowspan="1" colspan="1">19p13</td><td align="center" rowspan="1" colspan="1">10.26-10.5</td><td align="center" rowspan="1" colspan="1"><italic>TYK2</italic></td><td align="center" rowspan="1" colspan="1">rs12720356</td><td align="center" rowspan="1" colspan="1">C</td><td align="center" rowspan="1" colspan="1">0.08</td><td align="center" rowspan="1" colspan="1">9.20×10<sup>-10</sup></td><td align="center" rowspan="1" colspan="1">1.22 (1.14-1.31)</td><td align="center" rowspan="1" colspan="1">3.90×10<sup>-6</sup></td><td align="center" rowspan="1" colspan="1">1.17 (1.09-1.26)</td></tr><tr><td align="left" colspan="10" valign="bottom" rowspan="1"><hr></hr></td></tr><tr><td align="center" rowspan="1" colspan="1">19q13</td><td align="center" rowspan="1" colspan="1">38.42-38.47</td><td align="center" rowspan="1" colspan="1">-</td><td align="center" rowspan="1" colspan="1">rs736289</td><td align="center" rowspan="1" colspan="1">T</td><td align="center" rowspan="1" colspan="1">0.61</td><td align="center" rowspan="1" colspan="1">2.69×10<sup>-7</sup></td><td align="center" rowspan="1" colspan="1">1.11 (1.06-1.16)</td><td align="center" rowspan="1" colspan="1">1.89×10<sup>-5</sup></td><td align="center" rowspan="1" colspan="1">1.08 (1.03-1.12)</td></tr><tr><td align="left" colspan="10" valign="bottom" rowspan="1"><hr></hr></td></tr><tr><td align="center" rowspan="1" colspan="1">20q13</td><td align="center" rowspan="1" colspan="1">61.66-61.98</td><td align="center" rowspan="1" colspan="1"><italic>RTEL1/SLC2A4RG</italic></td><td align="center" rowspan="1" colspan="1">rs2297441</td><td align="center" rowspan="1" colspan="1">A</td><td align="center" rowspan="1" colspan="1">0.76</td><td align="center" rowspan="1" colspan="1">1.83×10<sup>-11</sup></td><td align="center" rowspan="1" colspan="1">1.19 (1.13-1.25)</td><td align="center" rowspan="1" colspan="1">5.78×10<sup>-8</sup></td><td align="center" rowspan="1" colspan="1">1.14 (1.09-1.20)</td></tr><tr><td align="left" colspan="10" valign="bottom" rowspan="1"><hr></hr></td></tr><tr><td align="center" rowspan="1" colspan="1">21q21</td><td align="center" rowspan="1" colspan="1">15.62-15.77</td><td align="center" rowspan="1" colspan="1">-</td><td align="center" rowspan="1" colspan="1">rs1297265</td><td align="center" rowspan="1" colspan="1">A</td><td align="center" rowspan="1" colspan="1">0.57</td><td align="center" rowspan="1" colspan="1">1.41×10<sup>-8</sup></td><td align="center" rowspan="1" colspan="1">1.16 (1.10-1.22)</td><td align="center" rowspan="1" colspan="1">1.73×10<sup>-7</sup></td><td align="center" rowspan="1" colspan="1">1.11 (1.06-1.16)</td></tr><tr><td align="left" colspan="10" valign="bottom" rowspan="1"><hr></hr></td></tr><tr><td align="center" rowspan="1" colspan="1">21q22</td><td align="center" rowspan="1" colspan="1">39.34-39.41</td><td align="center" rowspan="1" colspan="1">-</td><td align="center" rowspan="1" colspan="1">rs2836878</td><td align="center" rowspan="1" colspan="1">G</td><td align="center" rowspan="1" colspan="1">0.74</td><td align="center" rowspan="1" colspan="1">3.22×10<sup>-6</sup></td><td align="center" rowspan="1" colspan="1">1.12 (1.06-1.17)</td><td align="center" rowspan="1" colspan="1">1.86×10<sup>-22</sup></td><td align="center" rowspan="1" colspan="1">1.25 (1.20-1.32)</td></tr><tr><td align="left" colspan="10" valign="bottom" rowspan="1"><hr></hr></td></tr><tr><td align="center" rowspan="1" colspan="1">21q22</td><td align="center" rowspan="1" colspan="1">44.41-44.52</td><td align="center" rowspan="1" colspan="1"><italic>ICOSLG</italic></td><td align="center" rowspan="1" colspan="1">rs2838519</td><td align="center" rowspan="1" colspan="1">G</td><td align="center" rowspan="1" colspan="1">0.39</td><td align="center" rowspan="1" colspan="1">2.09×10<sup>-14</sup></td><td align="center" rowspan="1" colspan="1">1.18 (1.13-1.23)</td><td align="center" rowspan="1" colspan="1">2.26×10<sup>-8</sup></td><td align="center" rowspan="1" colspan="1">1.12 (1.08-1.17)</td></tr><tr><td align="left" colspan="10" valign="bottom" rowspan="1"><hr></hr></td></tr><tr><td align="center" rowspan="1" colspan="1">22q11</td><td align="center" rowspan="1" colspan="1">20.14-20.39</td><td align="center" rowspan="1" colspan="1"><italic>YDJC</italic></td><td align="center" rowspan="1" colspan="1">rs181359</td><td align="center" rowspan="1" colspan="1">A</td><td align="center" rowspan="1" colspan="1">0.19</td><td align="center" rowspan="1" colspan="1">6.31×10<sup>-13</sup></td><td align="center" rowspan="1" colspan="1">1.21 (1.15-1.28)</td><td align="center" rowspan="1" colspan="1">2.73×10<sup>-5</sup></td><td align="center" rowspan="1" colspan="1">1.11 (1.06-1.17)</td></tr></tbody></table></table-wrap></floats-group></pmc><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Belgique</li><li>Canada</li><li>Danemark</li><li>Espagne</li><li>France</li><li>Grèce</li><li>Israël</li><li>Italie</li><li>Lituanie</li><li>Norvège</li><li>Nouvelle-Zélande</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>Singapour</li><li>Suisse</li><li>Suède</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Angleterre de l'Est</li><li>Attique (région)</li><li>Bavière</li><li>Berlin</li><li>Californie</li><li>Canton de Berne</li><li>Catalogne</li><li>Connecticut</li><li>District de Haute-Bavière</li><li>Grand Est</li><li>Grand Londres</li><li>Grand Manchester</li><li>Groningue (province)</li><li>Géorgie (États-Unis)</li><li>Hauts-de-France</li><li>Hollande-Méridionale</li><li>Hollande-Septentrionale</li><li>Illinois</li><li>Lorraine (région)</li><li>Maryland</li><li>Massachusetts</li><li>Nord-Pas-de-Calais</li><li>Ohio</li><li>Ontario</li><li>Pennsylvanie</li><li>Province de Liège</li><li>Région de Bruxelles-Capitale</li><li>Région wallonne</li><li>Schleswig-Holstein</li><li>Svealand</li><li>Utah</li><li>Utrecht (province)</li><li>Washington (État)</li><li>Écosse</li><li>Île-de-France</li><li>Østlandet</li></region><settlement><li>Amsterdam</li><li>Athènes</li><li>Barcelone</li><li>Berlin</li><li>Berne</li><li>Bruxelles</li><li>Cambridge</li><li>Groningue</li><li>Kiel</li><li>Leyde</li><li>Lille</li><li>Liège</li><li>Londres</li><li>Manchester</li><li>Munich</li><li>Nancy</li><li>Oslo</li><li>Paris</li><li>Seattle</li><li>Stockholm</li><li>Toronto</li><li>Utrecht</li><li>Vandœuvre-lès-Nancy</li><li>Édimbourg</li></settlement><orgName><li>Université d'Édimbourg</li><li>Université de Berne</li><li>Université de Cambridge</li><li>Université de Liège</li><li>Université de Toronto</li><li>Université de Washington</li></orgName></list><tree><country name="Royaume-Uni"><noRegion><name sortKey="Anderson, Carl A" sort="Anderson, Carl A" uniqKey="Anderson C" first="Carl A." last="Anderson">Carl A. Anderson</name></noRegion><name sortKey="Ahmad, Tariq" sort="Ahmad, Tariq" uniqKey="Ahmad T" first="Tariq" last="Ahmad">Tariq Ahmad</name><name sortKey="Barrett, Jeffrey C" sort="Barrett, Jeffrey C" uniqKey="Barrett J" first="Jeffrey C." last="Barrett">Jeffrey C. Barrett</name><name sortKey="Bumpstead, Suzannah" sort="Bumpstead, Suzannah" uniqKey="Bumpstead S" first="Suzannah" last="Bumpstead">Suzannah Bumpstead</name><name sortKey="Edwards, Cathryn" sort="Edwards, Cathryn" uniqKey="Edwards C" first="Cathryn" last="Edwards">Cathryn Edwards</name><name sortKey="Floyd, James A B" sort="Floyd, James A B" uniqKey="Floyd J" first="James A. B." last="Floyd">James A. B. Floyd</name><name sortKey="Lee, James C" sort="Lee, James C" uniqKey="Lee J" first="James C." last="Lee">James C. Lee</name><name sortKey="Lees, Charlie W" sort="Lees, Charlie W" uniqKey="Lees C" first="Charlie W." last="Lees">Charlie W. Lees</name><name sortKey="Mansfield, John C" sort="Mansfield, John C" uniqKey="Mansfield J" first="John C." last="Mansfield">John C. Mansfield</name><name sortKey="Mathew, Christopher G" sort="Mathew, Christopher G" uniqKey="Mathew C" first="Christopher G." last="Mathew">Christopher G. Mathew</name><name sortKey="Morley, Katherine I" sort="Morley, Katherine I" uniqKey="Morley K" first="Katherine I." last="Morley">Katherine I. Morley</name><name sortKey="Mowat, Craig" sort="Mowat, Craig" uniqKey="Mowat C" first="Craig" last="Mowat">Craig Mowat</name><name sortKey="Newman, William" sort="Newman, William" uniqKey="Newman W" first="William" last="Newman">William Newman</name><name sortKey="Parkes, Miles" sort="Parkes, Miles" uniqKey="Parkes M" first="Miles" last="Parkes">Miles Parkes</name><name sortKey="Phillips, Anne" sort="Phillips, Anne" uniqKey="Phillips A" first="Anne" last="Phillips">Anne Phillips</name><name sortKey="Prescott, Natalie J" sort="Prescott, Natalie J" uniqKey="Prescott N" first="Natalie J." last="Prescott">Natalie J. Prescott</name><name sortKey="Russell, Richard" sort="Russell, Richard" uniqKey="Russell R" first="Richard" last="Russell">Richard Russell</name><name sortKey="Sanderson, Jeremy" sort="Sanderson, Jeremy" uniqKey="Sanderson J" first="Jeremy" last="Sanderson">Jeremy Sanderson</name><name sortKey="Satsangi, Jack" sort="Satsangi, Jack" uniqKey="Satsangi J" first="Jack" last="Satsangi">Jack Satsangi</name><name sortKey="Wilson, David C" sort="Wilson, David C" uniqKey="Wilson D" first="David C." last="Wilson">David C. Wilson</name><name sortKey="Wilson, David C" sort="Wilson, David C" uniqKey="Wilson D" first="David C." last="Wilson">David C. Wilson</name></country><country name="Canada"><noRegion><name sortKey="Boucher, Gabrielle" sort="Boucher, Gabrielle" uniqKey="Boucher G" first="Gabrielle" last="Boucher">Gabrielle Boucher</name></noRegion><name sortKey="Boucher, Gabrielle" sort="Boucher, Gabrielle" uniqKey="Boucher G" first="Gabrielle" last="Boucher">Gabrielle Boucher</name><name sortKey="Goyette, Philippe" sort="Goyette, Philippe" uniqKey="Goyette P" first="Philippe" last="Goyette">Philippe Goyette</name><name sortKey="Goyette, Philippe" sort="Goyette, Philippe" uniqKey="Goyette P" first="Philippe" last="Goyette">Philippe Goyette</name><name sortKey="Griffiths, Anne M" sort="Griffiths, Anne M" uniqKey="Griffiths A" first="Anne M." last="Griffiths">Anne M. Griffiths</name><name sortKey="Jobin, Gilles" sort="Jobin, Gilles" uniqKey="Jobin G" first="Gilles" last="Jobin">Gilles Jobin</name><name sortKey="Jobin, Gilles" sort="Jobin, Gilles" uniqKey="Jobin G" first="Gilles" last="Jobin">Gilles Jobin</name><name sortKey="Lagace, Caroline" sort="Lagace, Caroline" uniqKey="Lagace C" first="Caroline" last="Lagacé">Caroline Lagacé</name><name sortKey="Lagace, Caroline" sort="Lagace, Caroline" uniqKey="Lagace C" first="Caroline" last="Lagacé">Caroline Lagacé</name><name sortKey="Rioux, John D" sort="Rioux, John D" uniqKey="Rioux J" first="John D." last="Rioux">John D. Rioux</name><name sortKey="Rioux, John D" sort="Rioux, John D" uniqKey="Rioux J" first="John D." last="Rioux">John D. Rioux</name><name sortKey="Silverberg, Mark S" sort="Silverberg, Mark S" uniqKey="Silverberg M" first="Mark S." last="Silverberg">Mark S. Silverberg</name><name sortKey="Steinhart, A Hillary" sort="Steinhart, A Hillary" uniqKey="Steinhart A" first="A. Hillary" last="Steinhart">A. Hillary Steinhart</name><name sortKey="Walters, Thomas" sort="Walters, Thomas" uniqKey="Walters T" first="Thomas" last="Walters">Thomas Walters</name></country><country name="Allemagne"><region name="Schleswig-Holstein"><name sortKey="Franke, Andre" sort="Franke, Andre" uniqKey="Franke A" first="Andre" last="Franke">Andre Franke</name></region><name sortKey="Brand, Stephan" sort="Brand, Stephan" uniqKey="Brand S" first="Stephan" last="Brand">Stephan Brand</name><name sortKey="Buning, Carsten" sort="Buning, Carsten" uniqKey="Buning C" first="Carsten" last="Büning">Carsten Büning</name><name sortKey="Ellinghaus, David" sort="Ellinghaus, David" uniqKey="Ellinghaus D" first="David" last="Ellinghaus">David Ellinghaus</name><name sortKey="Glas, Jurgen" sort="Glas, Jurgen" uniqKey="Glas J" first="Jürgen" last="Glas">Jürgen Glas</name><name sortKey="Schreiber, Stefan" sort="Schreiber, Stefan" uniqKey="Schreiber S" first="Stefan" last="Schreiber">Stefan Schreiber</name><name sortKey="Schreiber, Stefan" sort="Schreiber, Stefan" uniqKey="Schreiber S" first="Stefan" last="Schreiber">Stefan Schreiber</name></country><country name="Suède"><region name="Svealand"><name sortKey="D Mato, Mauro" sort="D Mato, Mauro" uniqKey="D Mato M" first="Mauro" last="D Mato">Mauro D Mato</name></region><name sortKey="Halfvarson, Jonas" sort="Halfvarson, Jonas" uniqKey="Halfvarson J" first="Jonas" last="Halfvarson">Jonas Halfvarson</name><name sortKey="Torkvist, Leif" sort="Torkvist, Leif" uniqKey="Torkvist L" first="Leif" last="Torkvist">Leif Torkvist</name></country><country name="États-Unis"><region name="Californie"><name sortKey="Taylor, Kent D" sort="Taylor, Kent D" uniqKey="Taylor K" first="Kent D." last="Taylor">Kent D. Taylor</name></region><name sortKey="Baidoo, Leonard" sort="Baidoo, Leonard" uniqKey="Baidoo L" first="Leonard" last="Baidoo">Leonard Baidoo</name><name sortKey="Baldassano, Robert N" sort="Baldassano, Robert N" uniqKey="Baldassano R" first="Robert N." last="Baldassano">Robert N. Baldassano</name><name sortKey="Bayless, Theodore M" sort="Bayless, Theodore M" uniqKey="Bayless T" first="Theodore M." last="Bayless">Theodore M. Bayless</name><name sortKey="Brant, Steven R" sort="Brant, Steven R" uniqKey="Brant S" first="Steven R." last="Brant">Steven R. Brant</name><name sortKey="Cho, Judy H" sort="Cho, Judy H" uniqKey="Cho J" first="Judy H." last="Cho">Judy H. Cho</name><name sortKey="Daly, Mark J" sort="Daly, Mark J" uniqKey="Daly M" first="Mark J." last="Daly">Mark J. Daly</name><name sortKey="Denson, Lee A" sort="Denson, Lee A" uniqKey="Denson L" first="Lee A." last="Denson">Lee A. Denson</name><name sortKey="Dubinsky, Marla" sort="Dubinsky, Marla" uniqKey="Dubinsky M" first="Marla" last="Dubinsky">Marla Dubinsky</name><name sortKey="Duerr, Richard H" sort="Duerr, Richard H" uniqKey="Duerr R" first="Richard H." last="Duerr">Richard H. Duerr</name><name sortKey="Duerr, Richard H" sort="Duerr, Richard H" uniqKey="Duerr R" first="Richard H." last="Duerr">Richard H. Duerr</name><name sortKey="Glazer, Nicole L" sort="Glazer, Nicole L" uniqKey="Glazer N" first="Nicole L." last="Glazer">Nicole L. Glazer</name><name sortKey="Guthery, Stephen L" sort="Guthery, Stephen L" uniqKey="Guthery S" first="Stephen L." last="Guthery">Stephen L. Guthery</name><name sortKey="Hakonarson, Hakon" sort="Hakonarson, Hakon" uniqKey="Hakonarson H" first="Hakon" last="Hakonarson">Hakon Hakonarson</name><name sortKey="Hakonarson, Hakon" sort="Hakonarson, Hakon" uniqKey="Hakonarson H" first="Hakon" last="Hakonarson">Hakon Hakonarson</name><name sortKey="Haritunians, Talin" sort="Haritunians, Talin" uniqKey="Haritunians T" first="Talin" last="Haritunians">Talin Haritunians</name><name sortKey="Imielinski, Marcin" sort="Imielinski, Marcin" uniqKey="Imielinski M" first="Marcin" last="Imielinski">Marcin Imielinski</name><name sortKey="Kugathasan, Subra" sort="Kugathasan, Subra" uniqKey="Kugathasan S" first="Subra" last="Kugathasan">Subra Kugathasan</name><name sortKey="Mcgovern, Dermot P" sort="Mcgovern, Dermot P" uniqKey="Mcgovern D" first="Dermot P." last="Mcgovern">Dermot P. Mcgovern</name><name sortKey="Mcgovern, Dermot P" sort="Mcgovern, Dermot P" uniqKey="Mcgovern D" first="Dermot P." last="Mcgovern">Dermot P. Mcgovern</name><name sortKey="Ng, Aylwin" sort="Ng, Aylwin" uniqKey="Ng A" first="Aylwin" last="Ng">Aylwin Ng</name><name sortKey="Ng, Aylwin" sort="Ng, Aylwin" uniqKey="Ng A" first="Aylwin" last="Ng">Aylwin Ng</name><name sortKey="Proctor, Deborah D" sort="Proctor, Deborah D" uniqKey="Proctor D" first="Deborah D." last="Proctor">Deborah D. Proctor</name><name sortKey="Rotter, Jerome I" sort="Rotter, Jerome I" uniqKey="Rotter J" first="Jerome I." last="Rotter">Jerome I. Rotter</name><name sortKey="Schumm, Philip" sort="Schumm, Philip" uniqKey="Schumm P" first="Philip" last="Schumm">Philip Schumm</name><name sortKey="Scott, Regan" sort="Scott, Regan" uniqKey="Scott R" first="Regan" last="Scott">Regan Scott</name><name sortKey="Seielstad, Mark" sort="Seielstad, Mark" uniqKey="Seielstad M" first="Mark" last="Seielstad">Mark Seielstad</name><name sortKey="Sharma, Yashoda" sort="Sharma, Yashoda" uniqKey="Sharma Y" first="Yashoda" last="Sharma">Yashoda Sharma</name><name sortKey="Targan, Stephan R" sort="Targan, Stephan R" uniqKey="Targan S" first="Stephan R." last="Targan">Stephan R. Targan</name><name sortKey="Xavier, Ramnik J" sort="Xavier, Ramnik J" uniqKey="Xavier R" first="Ramnik J." last="Xavier">Ramnik J. Xavier</name><name sortKey="Xavier, Ramnik J" sort="Xavier, Ramnik J" uniqKey="Xavier R" first="Ramnik J." last="Xavier">Ramnik J. Xavier</name></country><country name="Italie"><noRegion><name sortKey="Latiano, Anna" sort="Latiano, Anna" uniqKey="Latiano A" first="Anna" last="Latiano">Anna Latiano</name></noRegion><name sortKey="Annese, Vito" sort="Annese, Vito" uniqKey="Annese V" first="Vito" last="Annese">Vito Annese</name><name sortKey="Annese, Vito" sort="Annese, Vito" uniqKey="Annese V" first="Vito" last="Annese">Vito Annese</name><name sortKey="Milla, Monica" sort="Milla, Monica" uniqKey="Milla M" first="Monica" last="Milla">Monica Milla</name><name sortKey="Palmieri, Orazio" sort="Palmieri, Orazio" uniqKey="Palmieri O" first="Orazio" last="Palmieri">Orazio Palmieri</name><name sortKey="Papi, Laura" sort="Papi, Laura" uniqKey="Papi L" first="Laura" last="Papi">Laura Papi</name></country><country name="Belgique"><region name="Région de Bruxelles-Capitale"><name sortKey="Amininejad, Leila" sort="Amininejad, Leila" uniqKey="Amininejad L" first="Leila" last="Amininejad">Leila Amininejad</name></region><name sortKey="De Vos, Martine" sort="De Vos, Martine" uniqKey="De Vos M" first="Martine" last="De Vos">Martine De Vos</name><name sortKey="Franchimont, Denis" sort="Franchimont, Denis" uniqKey="Franchimont D" first="Denis" last="Franchimont">Denis Franchimont</name><name sortKey="Georges, Michel" sort="Georges, Michel" uniqKey="Georges M" first="Michel" last="Georges">Michel Georges</name><name sortKey="Laukens, Debby" sort="Laukens, Debby" uniqKey="Laukens D" first="Debby" last="Laukens">Debby Laukens</name><name sortKey="Libioulle, Cecile" sort="Libioulle, Cecile" uniqKey="Libioulle C" first="Cecile" last="Libioulle">Cecile Libioulle</name><name sortKey="Louis, Edouard" sort="Louis, Edouard" uniqKey="Louis E" first="Edouard" last="Louis">Edouard Louis</name><name sortKey="Rutgeerts, Paul" sort="Rutgeerts, Paul" uniqKey="Rutgeerts P" first="Paul" last="Rutgeerts">Paul Rutgeerts</name><name sortKey="Vermeire, Severine" sort="Vermeire, Severine" uniqKey="Vermeire S" first="Séverine" last="Vermeire">Séverine Vermeire</name></country><country name="Nouvelle-Zélande"><noRegion><name sortKey="Barclay, Murray" sort="Barclay, Murray" uniqKey="Barclay M" first="Murray" last="Barclay">Murray Barclay</name></noRegion><name sortKey="Gearry, Richard" sort="Gearry, Richard" uniqKey="Gearry R" first="Richard" last="Gearry">Richard Gearry</name><name sortKey="Roberts, Rebecca" sort="Roberts, Rebecca" uniqKey="Roberts R" first="Rebecca" last="Roberts">Rebecca Roberts</name></country><country name="France"><region name="Hauts-de-France"><name sortKey="Colombel, Jean Frederic" sort="Colombel, Jean Frederic" uniqKey="Colombel J" first="Jean-Frédéric" last="Colombel">Jean-Frédéric Colombel</name></region><name sortKey="Chamaillard, Mathias" sort="Chamaillard, Mathias" uniqKey="Chamaillard M" first="Mathias" last="Chamaillard">Mathias Chamaillard</name><name sortKey="Hugot, Jean Pierre" sort="Hugot, Jean Pierre" uniqKey="Hugot J" first="Jean-Pierre" last="Hugot">Jean-Pierre Hugot</name><name sortKey="Lemann, Marc" sort="Lemann, Marc" uniqKey="Lemann M" first="Marc" last="Lémann">Marc Lémann</name><name sortKey="Peyrin Biroulet, Laurent" sort="Peyrin Biroulet, Laurent" uniqKey="Peyrin Biroulet L" first="Laurent" last="Peyrin-Biroulet">Laurent Peyrin-Biroulet</name></country><country name="Pays-Bas"><region name="Groningue (province)"><name sortKey="Fehrmann, Rudolf S N" sort="Fehrmann, Rudolf S N" uniqKey="Fehrmann R" first="Rudolf S. N." last="Fehrmann">Rudolf S. N. Fehrmann</name></region><name sortKey="Franke, Lude" sort="Franke, Lude" uniqKey="Franke L" first="Lude" last="Franke">Lude Franke</name><name sortKey="Ophoff, Roel A" sort="Ophoff, Roel A" uniqKey="Ophoff R" first="Roel A" last="Ophoff">Roel A. Ophoff</name><name sortKey="Ponsioen, Cyriel Y" sort="Ponsioen, Cyriel Y" uniqKey="Ponsioen C" first="Cyriel Y." last="Ponsioen">Cyriel Y. Ponsioen</name><name sortKey="Van Den Berg, Leonard H" sort="Van Den Berg, Leonard H" uniqKey="Van Den Berg L" first="Leonard H." last="Van Den Berg">Leonard H. Van Den Berg</name><name sortKey="Verspaget, Hein" sort="Verspaget, Hein" uniqKey="Verspaget H" first="Hein" last="Verspaget">Hein Verspaget</name><name sortKey="Weersma, Rinse K" sort="Weersma, Rinse K" uniqKey="Weersma R" first="Rinse K." last="Weersma">Rinse K. Weersma</name><name sortKey="Westra, Harm Jan" sort="Westra, Harm Jan" uniqKey="Westra H" first="Harm-Jan" last="Westra">Harm-Jan Westra</name><name sortKey="Wijmenga, Cisca" sort="Wijmenga, Cisca" uniqKey="Wijmenga C" first="Cisca" last="Wijmenga">Cisca Wijmenga</name></country><country name="Australie"><noRegion><name sortKey="Florin, Tim" sort="Florin, Tim" uniqKey="Florin T" first="Tim" last="Florin">Tim Florin</name></noRegion><name sortKey="Hayward, Nicholas K" sort="Hayward, Nicholas K" uniqKey="Hayward N" first="Nicholas K." last="Hayward">Nicholas K. Hayward</name><name sortKey="Lawrance, Ian" sort="Lawrance, Ian" uniqKey="Lawrance I" first="Ian" last="Lawrance">Ian Lawrance</name><name sortKey="Montgomery, Grant W" sort="Montgomery, Grant W" uniqKey="Montgomery G" first="Grant W." last="Montgomery">Grant W. Montgomery</name><name sortKey="Radford Smith, Graham" sort="Radford Smith, Graham" uniqKey="Radford Smith G" first="Graham" last="Radford-Smith">Graham Radford-Smith</name><name sortKey="Simms, Lisa" sort="Simms, Lisa" uniqKey="Simms L" first="Lisa" last="Simms">Lisa Simms</name><name sortKey="Zhao, Zhen Z" sort="Zhao, Zhen Z" uniqKey="Zhao Z" first="Zhen Z." last="Zhao">Zhen Z. Zhao</name></country><country name="Israël"><noRegion><name sortKey="Levine, Arie" sort="Levine, Arie" uniqKey="Levine A" first="Arie" last="Levine">Arie Levine</name></noRegion></country><country name="Espagne"><region name="Catalogne"><name sortKey="Panes, Julian" sort="Panes, Julian" uniqKey="Panes J" first="Julián" last="Panés">Julián Panés</name></region><name sortKey="Sans, Miquel" sort="Sans, Miquel" uniqKey="Sans M" first="Miquel" last="Sans">Miquel Sans</name></country><country name="Suisse"><region name="Canton de Berne"><name sortKey="Seibold, Frank" sort="Seibold, Frank" uniqKey="Seibold F" first="Frank" last="Seibold">Frank Seibold</name></region></country><country name="Singapour"><noRegion><name sortKey="Seielstad, Mark" sort="Seielstad, Mark" uniqKey="Seielstad M" first="Mark" last="Seielstad">Mark Seielstad</name></noRegion></country><country name="Norvège"><region name="Østlandet"><name sortKey="Vatn, Morten" sort="Vatn, Morten" uniqKey="Vatn M" first="Morten" last="Vatn">Morten Vatn</name></region><name sortKey="Karlsen, Tom H" sort="Karlsen, Tom H" uniqKey="Karlsen T" first="Tom H." last="Karlsen">Tom H. Karlsen</name></country><country name="Danemark"><noRegion><name sortKey="Andersen, Vibeke" sort="Andersen, Vibeke" uniqKey="Andersen V" first="Vibeke" last="Andersen">Vibeke Andersen</name></noRegion></country><country name="Grèce"><region name="Attique (région)"><name sortKey="Gazouli, Maria" sort="Gazouli, Maria" uniqKey="Gazouli M" first="Maria" last="Gazouli">Maria Gazouli</name></region><name sortKey="Anagnou, Nicholas P" sort="Anagnou, Nicholas P" uniqKey="Anagnou N" first="Nicholas P." last="Anagnou">Nicholas P. Anagnou</name></country><country name="Lituanie"><noRegion><name sortKey="Kupcinskas, Limas" sort="Kupcinskas, Limas" uniqKey="Kupcinskas L" first="Limas" last="Kupcinskas">Limas Kupcinskas</name></noRegion><name sortKey="Sventoraityte, Jurgita" sort="Sventoraityte, Jurgita" uniqKey="Sventoraityte J" first="Jurgita" last="Sventoraityte">Jurgita Sventoraityte</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Pmc/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002244 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Checkpoint/biblio.hfd -nk 002244 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= Pmc
|étape= Checkpoint
|type= RBID
|clé= PMC:3084597
|texte= Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Checkpoint/RBID.i -Sk "pubmed:21297633" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Checkpoint/biblio.hfd \
| NlmPubMed2Wicri -a AustralieFrV1
| This area was generated with Dilib version V0.6.33. |  |