Meta-analysis of New Genome-wide Association Studies of Colorectal Cancer Risk
Identifieur interne : 002243 ( Pmc/Checkpoint ); précédent : 002242; suivant : 002244Meta-analysis of New Genome-wide Association Studies of Colorectal Cancer Risk
Auteurs : Ulrike Peters [États-Unis] ; Carolyn M. Hutter [États-Unis] ; Li Hsu [États-Unis] ; Fredrick R. Schumacher [États-Unis] ; David V. Conti [États-Unis] ; Christopher S. Carlson [États-Unis] ; Christopher K. Edlund [États-Unis] ; Robert W. Haile [États-Unis] ; Steven Gallinger [Canada] ; Brent W. Zanke [Canada] ; Mathieu Lemire [Canada] ; Jagadish Rangrej [Canada] ; Raakhee Vijayaraghavan [États-Unis] ; Andrew T. Chan [États-Unis] ; Aditi Hazra [États-Unis] ; David J. Hunter [États-Unis] ; Jing Ma [États-Unis] ; Charles S. Fuchs [États-Unis] ; Edward L. Giovannucci [États-Unis] ; Peter Kraft [États-Unis] ; Yan Liu [États-Unis] ; Lin Chen [États-Unis] ; Shuo Jiao [États-Unis] ; Karen W. Makar [États-Unis] ; Darin Taverna [États-Unis] ; Stephen B. Gruber [États-Unis] ; Gad Rennert [Israël] ; Victor Moreno [Espagne] ; Cornelia M. Ulrich [États-Unis, Allemagne] ; Michael O. Woods [Canada] ; Roger C. Green [Canada] ; Patrick S. Parfrey [Canada] ; Ross L. Prentice [États-Unis] ; Charles Kooperberg [États-Unis] ; Rebecca D. Jackson [États-Unis] ; Andrea Z. Lacroix [États-Unis] ; Bette J. Caan [États-Unis] ; Richard B. Hayes [États-Unis] ; Sonja I. Berndt [États-Unis] ; Stephen J. Chanock [États-Unis] ; Robert E. Schoen [États-Unis] ; Jenny Chang-Claude [Allemagne] ; Michael Hoffmeister [Allemagne] ; Hermann Brenner [Allemagne] ; Bernd Frank [Allemagne] ; Stéphane Bézieau [France] ; Sébastien Küry [France] ; Martha L. Slattery [États-Unis] ; John L. Hopper [Australie] ; Mark A. Jenkins [Australie] ; Loic Le Marchand [États-Unis] ; Noralane M. Lindor [États-Unis] ; Polly A. Newcomb [États-Unis] ; Daniela Seminara [États-Unis] ; Thomas J. Hudson [Canada] ; David J. Duggan [États-Unis] ; John D. Potter [États-Unis] ; Graham Casey [États-Unis]Source :
- Human Genetics [ 0340-6717 ] ; 2011.
Abstract
Colorectal cancer is the second leading cause of cancer death in developed countries. Genome-wide association studies (GWAS) have successfully identified novel susceptibility loci for colorectal cancer. To follow-up on these findings, and try to identify novel colorectal cancer susceptibility loci, we present results for genome-wide association studies (GWAS) of colorectal cancer (2,906 cases, 3,416 controls) that have not previously published main associations. Specifically, we calculated odds ratios (ORs) and 95% confidence intervals (CIs) using log-additive models for each study. In order to improve our power to detect novel colorectal cancer susceptibility loci, we performed a meta-analysis combining the results across studies. We selected the most statistically significant single nucleotide polymorphisms (SNPs) for replication using 10 independent studies (8,161 cases and 9,101 controls). We again used a meta-analysis to summarize results for the replication studies alone, and for a combined analysis of GWAS and replication studies. We measured 10 SNPs previously identified in colorectal cancer susceptibility loci and found eight to be associated with colorectal cancer (p-value range: 0.02 to 1.8 × 10−8). When we excluded studies that have previously published on these SNPs, five SNPs remained significant at p<0.05 in the combined analysis. No novel susceptibility loci were significant in the replication study after adjustment for multiple testing, and none reached genome-wide significance from a combined analysis of GWAS and replication. We observed marginally significant evidence for a second independent SNP in the
Url:
DOI: 10.1007/s00439-011-1055-0
PubMed: 21761138
PubMed Central: 3257356
Affiliations:
- Allemagne, Australie, Canada, Espagne, France, Israël, États-Unis
- Bade-Wurtemberg, Californie, Catalogne, District de Karlsruhe, Illinois, Massachusetts, Ontario, Pays de la Loire, Pennsylvanie, Texas, Victoria (État), Washington (État), État de New York
- Barcelone, Boston, Chicago, Dallas, Heidelberg, Los Angeles, Melbourne, Nantes, New York, Pittsburgh, Seattle, Toronto
- Université de Californie du Sud, Université de Melbourne, Université de Toronto, Université de Washington
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Edlund</name><affiliation wicri:level="4"><nlm:aff id="A5">Keck School of Medicine, University of Southern California, Los Angeles, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Keck School of Medicine, University of Southern California, Los Angeles</wicri:regionArea><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author><author><name sortKey="Haile, Robert W" sort="Haile, Robert W" uniqKey="Haile R" first="Robert W." last="Haile">Robert W. Haile</name><affiliation wicri:level="4"><nlm:aff id="A4">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles</wicri:regionArea><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author><author><name sortKey="Gallinger, Steven" sort="Gallinger, Steven" uniqKey="Gallinger S" first="Steven" last="Gallinger">Steven Gallinger</name><affiliation wicri:level="1"><nlm:aff id="A6">Department of Surgery, University Health Network, Toronto General Hospital, Toronto, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Surgery, University Health Network, Toronto General Hospital, Toronto</wicri:regionArea><wicri:noRegion>Toronto</wicri:noRegion></affiliation></author><author><name sortKey="Zanke, Brent W" sort="Zanke, Brent W" uniqKey="Zanke B" first="Brent W." last="Zanke">Brent W. Zanke</name><affiliation wicri:level="1"><nlm:aff id="A7">Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa</wicri:regionArea><wicri:noRegion>Ottawa</wicri:noRegion></affiliation></author><author><name sortKey="Lemire, Mathieu" sort="Lemire, Mathieu" uniqKey="Lemire M" first="Mathieu" last="Lemire">Mathieu Lemire</name><affiliation wicri:level="1"><nlm:aff id="A8">Ontario Institute for Cancer Research, Toronto, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Ontario Institute for Cancer Research, Toronto</wicri:regionArea><wicri:noRegion>Toronto</wicri:noRegion></affiliation></author><author><name sortKey="Rangrej, Jagadish" sort="Rangrej, Jagadish" uniqKey="Rangrej J" first="Jagadish" last="Rangrej">Jagadish Rangrej</name><affiliation wicri:level="1"><nlm:aff id="A8">Ontario Institute for Cancer Research, Toronto, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Ontario Institute for Cancer Research, Toronto</wicri:regionArea><wicri:noRegion>Toronto</wicri:noRegion></affiliation></author><author><name sortKey="Vijayaraghavan, Raakhee" sort="Vijayaraghavan, Raakhee" uniqKey="Vijayaraghavan R" first="Raakhee" last="Vijayaraghavan">Raakhee Vijayaraghavan</name><affiliation wicri:level="1"><nlm:aff id="A9">Translational Genomics Research Institute, Phoenix, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Translational Genomics Research Institute, Phoenix</wicri:regionArea><wicri:noRegion>Phoenix</wicri:noRegion></affiliation></author><author><name sortKey="Chan, Andrew T" sort="Chan, Andrew T" uniqKey="Chan A" first="Andrew T." last="Chan">Andrew T. Chan</name><affiliation wicri:level="3"><nlm:aff id="A10">Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston</wicri:regionArea><placeName><settlement type="city">Boston</settlement><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A11">Channing Laboratory, Brigham and Women’s Hospital and Harvard Medical School, Boston, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Channing Laboratory, Brigham and Women’s Hospital and Harvard Medical School, Boston</wicri:regionArea><placeName><settlement type="city">Boston</settlement><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Hazra, Aditi" sort="Hazra, Aditi" uniqKey="Hazra A" first="Aditi" last="Hazra">Aditi Hazra</name><affiliation wicri:level="3"><nlm:aff id="A11">Channing Laboratory, Brigham and Women’s Hospital and Harvard Medical School, Boston, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Channing Laboratory, Brigham and Women’s Hospital and Harvard Medical School, Boston</wicri:regionArea><placeName><settlement type="city">Boston</settlement><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A12">Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, Boston, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, Boston</wicri:regionArea><placeName><settlement type="city">Boston</settlement><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Hunter, David J" sort="Hunter, David J" uniqKey="Hunter D" first="David J." last="Hunter">David J. Hunter</name><affiliation wicri:level="3"><nlm:aff id="A12">Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, Boston, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, Boston</wicri:regionArea><placeName><settlement type="city">Boston</settlement><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Ma, Jing" sort="Ma, Jing" uniqKey="Ma J" first="Jing" last="Ma">Jing Ma</name><affiliation wicri:level="3"><nlm:aff id="A11">Channing Laboratory, Brigham and Women’s Hospital and Harvard Medical School, Boston, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Channing Laboratory, Brigham and Women’s Hospital and Harvard Medical School, Boston</wicri:regionArea><placeName><settlement type="city">Boston</settlement><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Fuchs, Charles S" sort="Fuchs, Charles S" uniqKey="Fuchs C" first="Charles S." last="Fuchs">Charles S. Fuchs</name><affiliation wicri:level="3"><nlm:aff id="A11">Channing Laboratory, Brigham and Women’s Hospital and Harvard Medical School, Boston, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Channing Laboratory, Brigham and Women’s Hospital and Harvard Medical School, Boston</wicri:regionArea><placeName><settlement type="city">Boston</settlement><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A13">Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston</wicri:regionArea><placeName><settlement type="city">Boston</settlement><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Giovannucci, Edward L" sort="Giovannucci, Edward L" uniqKey="Giovannucci E" first="Edward L." last="Giovannucci">Edward L. Giovannucci</name><affiliation wicri:level="3"><nlm:aff id="A11">Channing Laboratory, Brigham and Women’s Hospital and Harvard Medical School, Boston, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Channing Laboratory, Brigham and Women’s Hospital and Harvard Medical School, Boston</wicri:regionArea><placeName><settlement type="city">Boston</settlement><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A14">Departments of Epidemiology and Nutrition, Harvard School of Public Health, Boston, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Epidemiology and Nutrition, Harvard School of Public Health, Boston</wicri:regionArea><placeName><settlement type="city">Boston</settlement><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name><affiliation wicri:level="3"><nlm:aff id="A12">Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, Boston, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, Boston</wicri:regionArea><placeName><settlement type="city">Boston</settlement><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Liu, Yan" sort="Liu, Yan" uniqKey="Liu Y" first="Yan" last="Liu">Yan Liu</name><affiliation wicri:level="3"><nlm:aff id="A15">Quantitative Services, Baylor Health Care System, Dallas, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Quantitative Services, Baylor Health Care System, Dallas</wicri:regionArea><placeName><settlement type="city">Dallas</settlement><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Chen, Lin" sort="Chen, Lin" uniqKey="Chen L" first="Lin" last="Chen">Lin Chen</name><affiliation wicri:level="3"><nlm:aff id="A16">Department of Health Studies, University of Chicago, Chicago, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Health Studies, University of Chicago, Chicago</wicri:regionArea><placeName><settlement type="city">Chicago</settlement><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Jiao, Shuo" sort="Jiao, Shuo" uniqKey="Jiao S" first="Shuo" last="Jiao">Shuo Jiao</name><affiliation wicri:level="1"><nlm:aff id="A1">Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle</wicri:regionArea><wicri:noRegion>Seattle</wicri:noRegion></affiliation></author><author><name sortKey="Makar, Karen W" sort="Makar, Karen W" uniqKey="Makar K" first="Karen W." last="Makar">Karen W. Makar</name><affiliation wicri:level="1"><nlm:aff id="A1">Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle</wicri:regionArea><wicri:noRegion>Seattle</wicri:noRegion></affiliation></author><author><name sortKey="Taverna, Darin" sort="Taverna, Darin" uniqKey="Taverna D" first="Darin" last="Taverna">Darin Taverna</name><affiliation wicri:level="1"><nlm:aff id="A9">Translational Genomics Research Institute, Phoenix, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Translational Genomics Research Institute, Phoenix</wicri:regionArea><wicri:noRegion>Phoenix</wicri:noRegion></affiliation></author><author><name sortKey="Gruber, Stephen B" sort="Gruber, Stephen B" uniqKey="Gruber S" first="Stephen B." last="Gruber">Stephen B. Gruber</name><affiliation wicri:level="1"><nlm:aff id="A17">Department of Internal Medicine, University of Michigan, Ann Arbor, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Internal Medicine, University of Michigan, Ann Arbor</wicri:regionArea><wicri:noRegion>Ann Arbor</wicri:noRegion></affiliation></author><author><name sortKey="Rennert, Gad" sort="Rennert, Gad" uniqKey="Rennert G" first="Gad" last="Rennert">Gad Rennert</name><affiliation wicri:level="1"><nlm:aff id="A18">Department of Community Medicine and Epidemiology, CarmelMedical Center and Technion Faculty of Medicine, Haifa, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Department of Community Medicine and Epidemiology, CarmelMedical Center and Technion Faculty of Medicine, Haifa</wicri:regionArea><wicri:noRegion>Haifa</wicri:noRegion></affiliation></author><author><name sortKey="Moreno, Victor" sort="Moreno, Victor" uniqKey="Moreno V" first="Victor" last="Moreno">Victor Moreno</name><affiliation wicri:level="3"><nlm:aff id="A19">Biostatistics and Bioinformatics Unit, Catalan Institute of Oncology-IDIBELL, Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Biostatistics and Bioinformatics Unit, Catalan Institute of Oncology-IDIBELL, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Ulrich, Cornelia M" sort="Ulrich, Cornelia M" uniqKey="Ulrich C" first="Cornelia M." last="Ulrich">Cornelia M. Ulrich</name><affiliation wicri:level="1"><nlm:aff id="A1">Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle</wicri:regionArea><wicri:noRegion>Seattle</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="A2">Department of Epidemiology, School of Public Health, University of Washington, Seattle, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, School of Public Health, University of Washington, Seattle</wicri:regionArea><orgName type="university">Université de Washington</orgName><placeName><settlement type="city">Seattle</settlement><region type="state">Washington (État)</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A20">Division of Preventive Oncology, German Cancer Research Center, Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Preventive Oncology, German Cancer Research Center, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Woods, Michael O" sort="Woods, Michael O" uniqKey="Woods M" first="Michael O." last="Woods">Michael O. Woods</name><affiliation wicri:level="1"><nlm:aff id="A21">Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John’s</wicri:regionArea><wicri:noRegion>St. John’s</wicri:noRegion></affiliation></author><author><name sortKey="Green, Roger C" sort="Green, Roger C" uniqKey="Green R" first="Roger C." last="Green">Roger C. Green</name><affiliation wicri:level="1"><nlm:aff id="A21">Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John’s</wicri:regionArea><wicri:noRegion>St. John’s</wicri:noRegion></affiliation></author><author><name sortKey="Parfrey, Patrick S" sort="Parfrey, Patrick S" uniqKey="Parfrey P" first="Patrick S." last="Parfrey">Patrick S. Parfrey</name><affiliation wicri:level="1"><nlm:aff id="A22">Discipline of Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Discipline of Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John’s</wicri:regionArea><wicri:noRegion>St. John’s</wicri:noRegion></affiliation></author><author><name sortKey="Prentice, Ross L" sort="Prentice, Ross L" uniqKey="Prentice R" first="Ross L." last="Prentice">Ross L. Prentice</name><affiliation wicri:level="1"><nlm:aff id="A23">Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle</wicri:regionArea><wicri:noRegion>Seattle</wicri:noRegion></affiliation></author><author><name sortKey="Kooperberg, Charles" sort="Kooperberg, Charles" uniqKey="Kooperberg C" first="Charles" last="Kooperberg">Charles Kooperberg</name><affiliation wicri:level="1"><nlm:aff id="A23">Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle</wicri:regionArea><wicri:noRegion>Seattle</wicri:noRegion></affiliation></author><author><name sortKey="Jackson, Rebecca D" sort="Jackson, Rebecca D" uniqKey="Jackson R" first="Rebecca D." last="Jackson">Rebecca D. Jackson</name><affiliation wicri:level="1"><nlm:aff id="A24">Division of Endocrinology, Diabetes and Metabolism, Ohio State University, Columbus, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Endocrinology, Diabetes and Metabolism, Ohio State University, Columbus</wicri:regionArea><wicri:noRegion>Columbus</wicri:noRegion></affiliation></author><author><name sortKey="Lacroix, Andrea Z" sort="Lacroix, Andrea Z" uniqKey="Lacroix A" first="Andrea Z." last="Lacroix">Andrea Z. Lacroix</name><affiliation wicri:level="1"><nlm:aff id="A1">Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle</wicri:regionArea><wicri:noRegion>Seattle</wicri:noRegion></affiliation></author><author><name sortKey="Caan, Bette J" sort="Caan, Bette J" uniqKey="Caan B" first="Bette J." last="Caan">Bette J. Caan</name><affiliation wicri:level="1"><nlm:aff id="A25">Division of Research, Kaiser Permanente Medical Care Program, Oakland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Research, Kaiser Permanente Medical Care Program, Oakland</wicri:regionArea><wicri:noRegion>Oakland</wicri:noRegion></affiliation></author><author><name sortKey="Hayes, Richard B" sort="Hayes, Richard B" uniqKey="Hayes R" first="Richard B." last="Hayes">Richard B. Hayes</name><affiliation wicri:level="3"><nlm:aff id="A26">Division of Epidemiology, Department of Environmental Medicine, New YorkUniversity School of Medicine, New York City, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Epidemiology, Department of Environmental Medicine, New YorkUniversity School of Medicine, New York City</wicri:regionArea><placeName><settlement type="city">New York</settlement><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Berndt, Sonja I" sort="Berndt, Sonja I" uniqKey="Berndt S" first="Sonja I." last="Berndt">Sonja I. Berndt</name><affiliation wicri:level="1"><nlm:aff id="A27">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda</wicri:regionArea><wicri:noRegion>Bethesda</wicri:noRegion></affiliation></author><author><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J." last="Chanock">Stephen J. Chanock</name><affiliation wicri:level="1"><nlm:aff id="A27">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda</wicri:regionArea><wicri:noRegion>Bethesda</wicri:noRegion></affiliation></author><author><name sortKey="Schoen, Robert E" sort="Schoen, Robert E" uniqKey="Schoen R" first="Robert E." last="Schoen">Robert E. Schoen</name><affiliation wicri:level="3"><nlm:aff id="A28">Department of Epidemiology, University of Pittsburgh Medical Center, Pittsburgh, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, University of Pittsburgh Medical Center, Pittsburgh</wicri:regionArea><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name><affiliation wicri:level="3"><nlm:aff id="A29">Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Hoffmeister, Michael" sort="Hoffmeister, Michael" uniqKey="Hoffmeister M" first="Michael" last="Hoffmeister">Michael Hoffmeister</name><affiliation wicri:level="3"><nlm:aff id="A30">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><affiliation wicri:level="3"><nlm:aff id="A30">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Frank, Bernd" sort="Frank, Bernd" uniqKey="Frank B" first="Bernd" last="Frank">Bernd Frank</name><affiliation wicri:level="3"><nlm:aff id="A30">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Bezieau, Stephane" sort="Bezieau, Stephane" uniqKey="Bezieau S" first="Stéphane" last="Bézieau">Stéphane Bézieau</name><affiliation wicri:level="3"><nlm:aff id="A31">Centre Hospitalier Universitaire (CHU) de Nantes, Pôle de Biologie, Service de Génétique Médicale, Nantes, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre Hospitalier Universitaire (CHU) de Nantes, Pôle de Biologie, Service de Génétique Médicale, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName></affiliation></author><author><name sortKey="Kury, Sebastien" sort="Kury, Sebastien" uniqKey="Kury S" first="Sébastien" last="Küry">Sébastien Küry</name><affiliation wicri:level="3"><nlm:aff id="A31">Centre Hospitalier Universitaire (CHU) de Nantes, Pôle de Biologie, Service de Génétique Médicale, Nantes, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre Hospitalier Universitaire (CHU) de Nantes, Pôle de Biologie, Service de Génétique Médicale, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName></affiliation></author><author><name sortKey="Slattery, Martha L" sort="Slattery, Martha L" uniqKey="Slattery M" first="Martha L." last="Slattery">Martha L. Slattery</name><affiliation wicri:level="1"><nlm:aff id="A32">Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City</wicri:regionArea><wicri:noRegion>Salt Lake City</wicri:noRegion></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name><affiliation wicri:level="4"><nlm:aff id="A33">Centre for Molecular, Environmental, Genetic, and Analytical Epidemiology, University of Melbourne, Melbourne, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Molecular, Environmental, Genetic, and Analytical Epidemiology, University of Melbourne, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region><settlement type="city">Melbourne</settlement></placeName><orgName type="university">Université de Melbourne</orgName></affiliation></author><author><name sortKey="Jenkins, Mark A" sort="Jenkins, Mark A" uniqKey="Jenkins M" first="Mark A." last="Jenkins">Mark A. Jenkins</name><affiliation wicri:level="4"><nlm:aff id="A33">Centre for Molecular, Environmental, Genetic, and Analytical Epidemiology, University of Melbourne, Melbourne, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Molecular, Environmental, Genetic, and Analytical Epidemiology, University of Melbourne, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region><settlement type="city">Melbourne</settlement></placeName><orgName type="university">Université de Melbourne</orgName></affiliation></author><author><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loic" last="Le Marchand">Loic Le Marchand</name><affiliation wicri:level="1"><nlm:aff id="A34">Epidemiology Program, Cancer Research Center of Hawai’i, University of Hawai’i at Manoa, Honolulu, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Epidemiology Program, Cancer Research Center of Hawai’i, University of Hawai’i at Manoa, Honolulu</wicri:regionArea><wicri:noRegion>Honolulu</wicri:noRegion></affiliation></author><author><name sortKey="Lindor, Noralane M" sort="Lindor, Noralane M" uniqKey="Lindor N" first="Noralane M." last="Lindor">Noralane M. Lindor</name><affiliation wicri:level="1"><nlm:aff id="A35">Department of Medical Genetics, Mayo Clinic, Rochester, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medical Genetics, Mayo Clinic, Rochester</wicri:regionArea><wicri:noRegion>Rochester</wicri:noRegion></affiliation></author><author><name sortKey="Newcomb, Polly A" sort="Newcomb, Polly A" uniqKey="Newcomb P" first="Polly A." last="Newcomb">Polly A. Newcomb</name><affiliation wicri:level="1"><nlm:aff id="A1">Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle</wicri:regionArea><wicri:noRegion>Seattle</wicri:noRegion></affiliation></author><author><name sortKey="Seminara, Daniela" sort="Seminara, Daniela" uniqKey="Seminara D" first="Daniela" last="Seminara">Daniela Seminara</name><affiliation wicri:level="1"><nlm:aff id="A36">Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda</wicri:regionArea><wicri:noRegion>Bethesda</wicri:noRegion></affiliation></author><author><name sortKey="Hudson, Thomas J" sort="Hudson, Thomas J" uniqKey="Hudson T" first="Thomas J." last="Hudson">Thomas J. Hudson</name><affiliation wicri:level="1"><nlm:aff id="A8">Ontario Institute for Cancer Research, Toronto, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Ontario Institute for Cancer Research, Toronto</wicri:regionArea><wicri:noRegion>Toronto</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="A37">Departments of Medical Biophysics and Molecular Genetics, University of Toronto, Toronto, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Departments of Medical Biophysics and Molecular Genetics, University of Toronto, Toronto</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Duggan, David J" sort="Duggan, David J" uniqKey="Duggan D" first="David J." last="Duggan">David J. Duggan</name><affiliation wicri:level="1"><nlm:aff id="A9">Translational Genomics Research Institute, Phoenix, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Translational Genomics Research Institute, Phoenix</wicri:regionArea><wicri:noRegion>Phoenix</wicri:noRegion></affiliation></author><author><name sortKey="Potter, John D" sort="Potter, John D" uniqKey="Potter J" first="John D." last="Potter">John D. Potter</name><affiliation wicri:level="4"><nlm:aff id="A2">Department of Epidemiology, School of Public Health, University of Washington, Seattle, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, School of Public Health, University of Washington, Seattle</wicri:regionArea><orgName type="university">Université de Washington</orgName><placeName><settlement type="city">Seattle</settlement><region type="state">Washington (État)</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A23">Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle</wicri:regionArea><wicri:noRegion>Seattle</wicri:noRegion></affiliation></author><author><name sortKey="Casey, Graham" sort="Casey, Graham" uniqKey="Casey G" first="Graham" last="Casey">Graham Casey</name><affiliation wicri:level="4"><nlm:aff id="A4">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles</wicri:regionArea><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">21761138</idno><idno type="pmc">3257356</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257356</idno><idno type="RBID">PMC:3257356</idno><idno type="doi">10.1007/s00439-011-1055-0</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">001546</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001546</idno><idno type="wicri:Area/Pmc/Curation">001406</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001406</idno><idno type="wicri:Area/Pmc/Checkpoint">002243</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002243</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Meta-analysis of New Genome-wide Association Studies of Colorectal Cancer Risk</title><author><name sortKey="Peters, Ulrike" sort="Peters, Ulrike" uniqKey="Peters U" first="Ulrike" last="Peters">Ulrike Peters</name><affiliation wicri:level="1"><nlm:aff id="A1">Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle</wicri:regionArea><wicri:noRegion>Seattle</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="A2">Department of Epidemiology, School of Public Health, University of Washington, Seattle, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, School of Public Health, University of Washington, Seattle</wicri:regionArea><orgName type="university">Université de Washington</orgName><placeName><settlement type="city">Seattle</settlement><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Hutter, Carolyn M" sort="Hutter, Carolyn M" uniqKey="Hutter C" first="Carolyn M." last="Hutter">Carolyn M. Hutter</name><affiliation wicri:level="1"><nlm:aff id="A1">Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle</wicri:regionArea><wicri:noRegion>Seattle</wicri:noRegion></affiliation></author><author><name sortKey="Hsu, Li" sort="Hsu, Li" uniqKey="Hsu L" first="Li" last="Hsu">Li Hsu</name><affiliation wicri:level="1"><nlm:aff id="A3">Biostatistics and Biomathematics, Fred Hutchinson Cancer Research Center, Seattle, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Biostatistics and Biomathematics, Fred Hutchinson Cancer Research Center, Seattle</wicri:regionArea><wicri:noRegion>Seattle</wicri:noRegion></affiliation></author><author><name sortKey="Schumacher, Fredrick R" sort="Schumacher, Fredrick R" uniqKey="Schumacher F" first="Fredrick R." last="Schumacher">Fredrick R. Schumacher</name><affiliation wicri:level="4"><nlm:aff id="A4">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles</wicri:regionArea><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author><author><name sortKey="Conti, David V" sort="Conti, David V" uniqKey="Conti D" first="David V." last="Conti">David V. Conti</name><affiliation wicri:level="4"><nlm:aff id="A4">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles</wicri:regionArea><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author><author><name sortKey="Carlson, Christopher S" sort="Carlson, Christopher S" uniqKey="Carlson C" first="Christopher S." last="Carlson">Christopher S. Carlson</name><affiliation wicri:level="1"><nlm:aff id="A1">Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle</wicri:regionArea><wicri:noRegion>Seattle</wicri:noRegion></affiliation></author><author><name sortKey="Edlund, Christopher K" sort="Edlund, Christopher K" uniqKey="Edlund C" first="Christopher K." last="Edlund">Christopher K. Edlund</name><affiliation wicri:level="4"><nlm:aff id="A5">Keck School of Medicine, University of Southern California, Los Angeles, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Keck School of Medicine, University of Southern California, Los Angeles</wicri:regionArea><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author><author><name sortKey="Haile, Robert W" sort="Haile, Robert W" uniqKey="Haile R" first="Robert W." last="Haile">Robert W. Haile</name><affiliation wicri:level="4"><nlm:aff id="A4">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles</wicri:regionArea><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author><author><name sortKey="Gallinger, Steven" sort="Gallinger, Steven" uniqKey="Gallinger S" first="Steven" last="Gallinger">Steven Gallinger</name><affiliation wicri:level="1"><nlm:aff id="A6">Department of Surgery, University Health Network, Toronto General Hospital, Toronto, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Surgery, University Health Network, Toronto General Hospital, Toronto</wicri:regionArea><wicri:noRegion>Toronto</wicri:noRegion></affiliation></author><author><name sortKey="Zanke, Brent W" sort="Zanke, Brent W" uniqKey="Zanke B" first="Brent W." last="Zanke">Brent W. Zanke</name><affiliation wicri:level="1"><nlm:aff id="A7">Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa</wicri:regionArea><wicri:noRegion>Ottawa</wicri:noRegion></affiliation></author><author><name sortKey="Lemire, Mathieu" sort="Lemire, Mathieu" uniqKey="Lemire M" first="Mathieu" last="Lemire">Mathieu Lemire</name><affiliation wicri:level="1"><nlm:aff id="A8">Ontario Institute for Cancer Research, Toronto, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Ontario Institute for Cancer Research, Toronto</wicri:regionArea><wicri:noRegion>Toronto</wicri:noRegion></affiliation></author><author><name sortKey="Rangrej, Jagadish" sort="Rangrej, Jagadish" uniqKey="Rangrej J" first="Jagadish" last="Rangrej">Jagadish Rangrej</name><affiliation wicri:level="1"><nlm:aff id="A8">Ontario Institute for Cancer Research, Toronto, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Ontario Institute for Cancer Research, Toronto</wicri:regionArea><wicri:noRegion>Toronto</wicri:noRegion></affiliation></author><author><name sortKey="Vijayaraghavan, Raakhee" sort="Vijayaraghavan, Raakhee" uniqKey="Vijayaraghavan R" first="Raakhee" last="Vijayaraghavan">Raakhee Vijayaraghavan</name><affiliation wicri:level="1"><nlm:aff id="A9">Translational Genomics Research Institute, Phoenix, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Translational Genomics Research Institute, Phoenix</wicri:regionArea><wicri:noRegion>Phoenix</wicri:noRegion></affiliation></author><author><name sortKey="Chan, Andrew T" sort="Chan, Andrew T" uniqKey="Chan A" first="Andrew T." last="Chan">Andrew T. Chan</name><affiliation wicri:level="3"><nlm:aff id="A10">Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston</wicri:regionArea><placeName><settlement type="city">Boston</settlement><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A11">Channing Laboratory, Brigham and Women’s Hospital and Harvard Medical School, Boston, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Channing Laboratory, Brigham and Women’s Hospital and Harvard Medical School, Boston</wicri:regionArea><placeName><settlement type="city">Boston</settlement><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Hazra, Aditi" sort="Hazra, Aditi" uniqKey="Hazra A" first="Aditi" last="Hazra">Aditi Hazra</name><affiliation wicri:level="3"><nlm:aff id="A11">Channing Laboratory, Brigham and Women’s Hospital and Harvard Medical School, Boston, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Channing Laboratory, Brigham and Women’s Hospital and Harvard Medical School, Boston</wicri:regionArea><placeName><settlement type="city">Boston</settlement><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A12">Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, Boston, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, Boston</wicri:regionArea><placeName><settlement type="city">Boston</settlement><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Hunter, David J" sort="Hunter, David J" uniqKey="Hunter D" first="David J." last="Hunter">David J. Hunter</name><affiliation wicri:level="3"><nlm:aff id="A12">Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, Boston, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, Boston</wicri:regionArea><placeName><settlement type="city">Boston</settlement><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Ma, Jing" sort="Ma, Jing" uniqKey="Ma J" first="Jing" last="Ma">Jing Ma</name><affiliation wicri:level="3"><nlm:aff id="A11">Channing Laboratory, Brigham and Women’s Hospital and Harvard Medical School, Boston, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Channing Laboratory, Brigham and Women’s Hospital and Harvard Medical School, Boston</wicri:regionArea><placeName><settlement type="city">Boston</settlement><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Fuchs, Charles S" sort="Fuchs, Charles S" uniqKey="Fuchs C" first="Charles S." last="Fuchs">Charles S. Fuchs</name><affiliation wicri:level="3"><nlm:aff id="A11">Channing Laboratory, Brigham and Women’s Hospital and Harvard Medical School, Boston, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Channing Laboratory, Brigham and Women’s Hospital and Harvard Medical School, Boston</wicri:regionArea><placeName><settlement type="city">Boston</settlement><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A13">Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston</wicri:regionArea><placeName><settlement type="city">Boston</settlement><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Giovannucci, Edward L" sort="Giovannucci, Edward L" uniqKey="Giovannucci E" first="Edward L." last="Giovannucci">Edward L. Giovannucci</name><affiliation wicri:level="3"><nlm:aff id="A11">Channing Laboratory, Brigham and Women’s Hospital and Harvard Medical School, Boston, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Channing Laboratory, Brigham and Women’s Hospital and Harvard Medical School, Boston</wicri:regionArea><placeName><settlement type="city">Boston</settlement><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A14">Departments of Epidemiology and Nutrition, Harvard School of Public Health, Boston, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Epidemiology and Nutrition, Harvard School of Public Health, Boston</wicri:regionArea><placeName><settlement type="city">Boston</settlement><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name><affiliation wicri:level="3"><nlm:aff id="A12">Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, Boston, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, Boston</wicri:regionArea><placeName><settlement type="city">Boston</settlement><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Liu, Yan" sort="Liu, Yan" uniqKey="Liu Y" first="Yan" last="Liu">Yan Liu</name><affiliation wicri:level="3"><nlm:aff id="A15">Quantitative Services, Baylor Health Care System, Dallas, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Quantitative Services, Baylor Health Care System, Dallas</wicri:regionArea><placeName><settlement type="city">Dallas</settlement><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Chen, Lin" sort="Chen, Lin" uniqKey="Chen L" first="Lin" last="Chen">Lin Chen</name><affiliation wicri:level="3"><nlm:aff id="A16">Department of Health Studies, University of Chicago, Chicago, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Health Studies, University of Chicago, Chicago</wicri:regionArea><placeName><settlement type="city">Chicago</settlement><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Jiao, Shuo" sort="Jiao, Shuo" uniqKey="Jiao S" first="Shuo" last="Jiao">Shuo Jiao</name><affiliation wicri:level="1"><nlm:aff id="A1">Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle</wicri:regionArea><wicri:noRegion>Seattle</wicri:noRegion></affiliation></author><author><name sortKey="Makar, Karen W" sort="Makar, Karen W" uniqKey="Makar K" first="Karen W." last="Makar">Karen W. Makar</name><affiliation wicri:level="1"><nlm:aff id="A1">Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle</wicri:regionArea><wicri:noRegion>Seattle</wicri:noRegion></affiliation></author><author><name sortKey="Taverna, Darin" sort="Taverna, Darin" uniqKey="Taverna D" first="Darin" last="Taverna">Darin Taverna</name><affiliation wicri:level="1"><nlm:aff id="A9">Translational Genomics Research Institute, Phoenix, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Translational Genomics Research Institute, Phoenix</wicri:regionArea><wicri:noRegion>Phoenix</wicri:noRegion></affiliation></author><author><name sortKey="Gruber, Stephen B" sort="Gruber, Stephen B" uniqKey="Gruber S" first="Stephen B." last="Gruber">Stephen B. Gruber</name><affiliation wicri:level="1"><nlm:aff id="A17">Department of Internal Medicine, University of Michigan, Ann Arbor, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Internal Medicine, University of Michigan, Ann Arbor</wicri:regionArea><wicri:noRegion>Ann Arbor</wicri:noRegion></affiliation></author><author><name sortKey="Rennert, Gad" sort="Rennert, Gad" uniqKey="Rennert G" first="Gad" last="Rennert">Gad Rennert</name><affiliation wicri:level="1"><nlm:aff id="A18">Department of Community Medicine and Epidemiology, CarmelMedical Center and Technion Faculty of Medicine, Haifa, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Department of Community Medicine and Epidemiology, CarmelMedical Center and Technion Faculty of Medicine, Haifa</wicri:regionArea><wicri:noRegion>Haifa</wicri:noRegion></affiliation></author><author><name sortKey="Moreno, Victor" sort="Moreno, Victor" uniqKey="Moreno V" first="Victor" last="Moreno">Victor Moreno</name><affiliation wicri:level="3"><nlm:aff id="A19">Biostatistics and Bioinformatics Unit, Catalan Institute of Oncology-IDIBELL, Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Biostatistics and Bioinformatics Unit, Catalan Institute of Oncology-IDIBELL, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Ulrich, Cornelia M" sort="Ulrich, Cornelia M" uniqKey="Ulrich C" first="Cornelia M." last="Ulrich">Cornelia M. Ulrich</name><affiliation wicri:level="1"><nlm:aff id="A1">Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle</wicri:regionArea><wicri:noRegion>Seattle</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="A2">Department of Epidemiology, School of Public Health, University of Washington, Seattle, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, School of Public Health, University of Washington, Seattle</wicri:regionArea><orgName type="university">Université de Washington</orgName><placeName><settlement type="city">Seattle</settlement><region type="state">Washington (État)</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A20">Division of Preventive Oncology, German Cancer Research Center, Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Preventive Oncology, German Cancer Research Center, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Woods, Michael O" sort="Woods, Michael O" uniqKey="Woods M" first="Michael O." last="Woods">Michael O. Woods</name><affiliation wicri:level="1"><nlm:aff id="A21">Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John’s</wicri:regionArea><wicri:noRegion>St. John’s</wicri:noRegion></affiliation></author><author><name sortKey="Green, Roger C" sort="Green, Roger C" uniqKey="Green R" first="Roger C." last="Green">Roger C. Green</name><affiliation wicri:level="1"><nlm:aff id="A21">Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John’s</wicri:regionArea><wicri:noRegion>St. John’s</wicri:noRegion></affiliation></author><author><name sortKey="Parfrey, Patrick S" sort="Parfrey, Patrick S" uniqKey="Parfrey P" first="Patrick S." last="Parfrey">Patrick S. Parfrey</name><affiliation wicri:level="1"><nlm:aff id="A22">Discipline of Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Discipline of Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John’s</wicri:regionArea><wicri:noRegion>St. John’s</wicri:noRegion></affiliation></author><author><name sortKey="Prentice, Ross L" sort="Prentice, Ross L" uniqKey="Prentice R" first="Ross L." last="Prentice">Ross L. Prentice</name><affiliation wicri:level="1"><nlm:aff id="A23">Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle</wicri:regionArea><wicri:noRegion>Seattle</wicri:noRegion></affiliation></author><author><name sortKey="Kooperberg, Charles" sort="Kooperberg, Charles" uniqKey="Kooperberg C" first="Charles" last="Kooperberg">Charles Kooperberg</name><affiliation wicri:level="1"><nlm:aff id="A23">Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle</wicri:regionArea><wicri:noRegion>Seattle</wicri:noRegion></affiliation></author><author><name sortKey="Jackson, Rebecca D" sort="Jackson, Rebecca D" uniqKey="Jackson R" first="Rebecca D." last="Jackson">Rebecca D. Jackson</name><affiliation wicri:level="1"><nlm:aff id="A24">Division of Endocrinology, Diabetes and Metabolism, Ohio State University, Columbus, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Endocrinology, Diabetes and Metabolism, Ohio State University, Columbus</wicri:regionArea><wicri:noRegion>Columbus</wicri:noRegion></affiliation></author><author><name sortKey="Lacroix, Andrea Z" sort="Lacroix, Andrea Z" uniqKey="Lacroix A" first="Andrea Z." last="Lacroix">Andrea Z. Lacroix</name><affiliation wicri:level="1"><nlm:aff id="A1">Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle</wicri:regionArea><wicri:noRegion>Seattle</wicri:noRegion></affiliation></author><author><name sortKey="Caan, Bette J" sort="Caan, Bette J" uniqKey="Caan B" first="Bette J." last="Caan">Bette J. Caan</name><affiliation wicri:level="1"><nlm:aff id="A25">Division of Research, Kaiser Permanente Medical Care Program, Oakland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Research, Kaiser Permanente Medical Care Program, Oakland</wicri:regionArea><wicri:noRegion>Oakland</wicri:noRegion></affiliation></author><author><name sortKey="Hayes, Richard B" sort="Hayes, Richard B" uniqKey="Hayes R" first="Richard B." last="Hayes">Richard B. Hayes</name><affiliation wicri:level="3"><nlm:aff id="A26">Division of Epidemiology, Department of Environmental Medicine, New YorkUniversity School of Medicine, New York City, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Epidemiology, Department of Environmental Medicine, New YorkUniversity School of Medicine, New York City</wicri:regionArea><placeName><settlement type="city">New York</settlement><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Berndt, Sonja I" sort="Berndt, Sonja I" uniqKey="Berndt S" first="Sonja I." last="Berndt">Sonja I. Berndt</name><affiliation wicri:level="1"><nlm:aff id="A27">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda</wicri:regionArea><wicri:noRegion>Bethesda</wicri:noRegion></affiliation></author><author><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J." last="Chanock">Stephen J. Chanock</name><affiliation wicri:level="1"><nlm:aff id="A27">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda</wicri:regionArea><wicri:noRegion>Bethesda</wicri:noRegion></affiliation></author><author><name sortKey="Schoen, Robert E" sort="Schoen, Robert E" uniqKey="Schoen R" first="Robert E." last="Schoen">Robert E. Schoen</name><affiliation wicri:level="3"><nlm:aff id="A28">Department of Epidemiology, University of Pittsburgh Medical Center, Pittsburgh, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, University of Pittsburgh Medical Center, Pittsburgh</wicri:regionArea><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name><affiliation wicri:level="3"><nlm:aff id="A29">Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Hoffmeister, Michael" sort="Hoffmeister, Michael" uniqKey="Hoffmeister M" first="Michael" last="Hoffmeister">Michael Hoffmeister</name><affiliation wicri:level="3"><nlm:aff id="A30">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><affiliation wicri:level="3"><nlm:aff id="A30">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Frank, Bernd" sort="Frank, Bernd" uniqKey="Frank B" first="Bernd" last="Frank">Bernd Frank</name><affiliation wicri:level="3"><nlm:aff id="A30">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Bezieau, Stephane" sort="Bezieau, Stephane" uniqKey="Bezieau S" first="Stéphane" last="Bézieau">Stéphane Bézieau</name><affiliation wicri:level="3"><nlm:aff id="A31">Centre Hospitalier Universitaire (CHU) de Nantes, Pôle de Biologie, Service de Génétique Médicale, Nantes, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre Hospitalier Universitaire (CHU) de Nantes, Pôle de Biologie, Service de Génétique Médicale, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName></affiliation></author><author><name sortKey="Kury, Sebastien" sort="Kury, Sebastien" uniqKey="Kury S" first="Sébastien" last="Küry">Sébastien Küry</name><affiliation wicri:level="3"><nlm:aff id="A31">Centre Hospitalier Universitaire (CHU) de Nantes, Pôle de Biologie, Service de Génétique Médicale, Nantes, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre Hospitalier Universitaire (CHU) de Nantes, Pôle de Biologie, Service de Génétique Médicale, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName></affiliation></author><author><name sortKey="Slattery, Martha L" sort="Slattery, Martha L" uniqKey="Slattery M" first="Martha L." last="Slattery">Martha L. Slattery</name><affiliation wicri:level="1"><nlm:aff id="A32">Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City</wicri:regionArea><wicri:noRegion>Salt Lake City</wicri:noRegion></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name><affiliation wicri:level="4"><nlm:aff id="A33">Centre for Molecular, Environmental, Genetic, and Analytical Epidemiology, University of Melbourne, Melbourne, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Molecular, Environmental, Genetic, and Analytical Epidemiology, University of Melbourne, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region><settlement type="city">Melbourne</settlement></placeName><orgName type="university">Université de Melbourne</orgName></affiliation></author><author><name sortKey="Jenkins, Mark A" sort="Jenkins, Mark A" uniqKey="Jenkins M" first="Mark A." last="Jenkins">Mark A. Jenkins</name><affiliation wicri:level="4"><nlm:aff id="A33">Centre for Molecular, Environmental, Genetic, and Analytical Epidemiology, University of Melbourne, Melbourne, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Molecular, Environmental, Genetic, and Analytical Epidemiology, University of Melbourne, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region><settlement type="city">Melbourne</settlement></placeName><orgName type="university">Université de Melbourne</orgName></affiliation></author><author><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loic" last="Le Marchand">Loic Le Marchand</name><affiliation wicri:level="1"><nlm:aff id="A34">Epidemiology Program, Cancer Research Center of Hawai’i, University of Hawai’i at Manoa, Honolulu, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Epidemiology Program, Cancer Research Center of Hawai’i, University of Hawai’i at Manoa, Honolulu</wicri:regionArea><wicri:noRegion>Honolulu</wicri:noRegion></affiliation></author><author><name sortKey="Lindor, Noralane M" sort="Lindor, Noralane M" uniqKey="Lindor N" first="Noralane M." last="Lindor">Noralane M. Lindor</name><affiliation wicri:level="1"><nlm:aff id="A35">Department of Medical Genetics, Mayo Clinic, Rochester, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medical Genetics, Mayo Clinic, Rochester</wicri:regionArea><wicri:noRegion>Rochester</wicri:noRegion></affiliation></author><author><name sortKey="Newcomb, Polly A" sort="Newcomb, Polly A" uniqKey="Newcomb P" first="Polly A." last="Newcomb">Polly A. Newcomb</name><affiliation wicri:level="1"><nlm:aff id="A1">Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle</wicri:regionArea><wicri:noRegion>Seattle</wicri:noRegion></affiliation></author><author><name sortKey="Seminara, Daniela" sort="Seminara, Daniela" uniqKey="Seminara D" first="Daniela" last="Seminara">Daniela Seminara</name><affiliation wicri:level="1"><nlm:aff id="A36">Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda</wicri:regionArea><wicri:noRegion>Bethesda</wicri:noRegion></affiliation></author><author><name sortKey="Hudson, Thomas J" sort="Hudson, Thomas J" uniqKey="Hudson T" first="Thomas J." last="Hudson">Thomas J. Hudson</name><affiliation wicri:level="1"><nlm:aff id="A8">Ontario Institute for Cancer Research, Toronto, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Ontario Institute for Cancer Research, Toronto</wicri:regionArea><wicri:noRegion>Toronto</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="A37">Departments of Medical Biophysics and Molecular Genetics, University of Toronto, Toronto, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Departments of Medical Biophysics and Molecular Genetics, University of Toronto, Toronto</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Duggan, David J" sort="Duggan, David J" uniqKey="Duggan D" first="David J." last="Duggan">David J. Duggan</name><affiliation wicri:level="1"><nlm:aff id="A9">Translational Genomics Research Institute, Phoenix, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Translational Genomics Research Institute, Phoenix</wicri:regionArea><wicri:noRegion>Phoenix</wicri:noRegion></affiliation></author><author><name sortKey="Potter, John D" sort="Potter, John D" uniqKey="Potter J" first="John D." last="Potter">John D. Potter</name><affiliation wicri:level="4"><nlm:aff id="A2">Department of Epidemiology, School of Public Health, University of Washington, Seattle, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, School of Public Health, University of Washington, Seattle</wicri:regionArea><orgName type="university">Université de Washington</orgName><placeName><settlement type="city">Seattle</settlement><region type="state">Washington (État)</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A23">Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle</wicri:regionArea><wicri:noRegion>Seattle</wicri:noRegion></affiliation></author><author><name sortKey="Casey, Graham" sort="Casey, Graham" uniqKey="Casey G" first="Graham" last="Casey">Graham Casey</name><affiliation wicri:level="4"><nlm:aff id="A4">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles</wicri:regionArea><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author></analytic><series><title level="j">Human Genetics</title><idno type="ISSN">0340-6717</idno><idno type="eISSN">1432-1203</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Colorectal cancer is the second leading cause of cancer death in developed countries. Genome-wide association studies (GWAS) have successfully identified novel susceptibility loci for colorectal cancer. To follow-up on these findings, and try to identify novel colorectal cancer susceptibility loci, we present results for genome-wide association studies (GWAS) of colorectal cancer (2,906 cases, 3,416 controls) that have not previously published main associations. Specifically, we calculated odds ratios (ORs) and 95% confidence intervals (CIs) using log-additive models for each study. In order to improve our power to detect novel colorectal cancer susceptibility loci, we performed a meta-analysis combining the results across studies. We selected the most statistically significant single nucleotide polymorphisms (SNPs) for replication using 10 independent studies (8,161 cases and 9,101 controls). We again used a meta-analysis to summarize results for the replication studies alone, and for a combined analysis of GWAS and replication studies. We measured 10 SNPs previously identified in colorectal cancer susceptibility loci and found eight to be associated with colorectal cancer (p-value range: 0.02 to 1.8 × 10<sup>−8</sup>). When we excluded studies that have previously published on these SNPs, five SNPs remained significant at p<0.05 in the combined analysis. No novel susceptibility loci were significant in the replication study after adjustment for multiple testing, and none reached genome-wide significance from a combined analysis of GWAS and replication. We observed marginally significant evidence for a second independent SNP in the <italic>BMP2</italic> region at chromosomal location 20p12 (rs4813802; replication p-value 0.03; combined p-value 7.3 × 10<sup>−5</sup>). In a region on 5p33.15, which includes the coding regions of the <italic>TERT-CLPTM1L</italic> genes and has been identified in GWAS to be associated with susceptibility to at least seven other cancers, we observed a marginally significant association with rs2853668 (replication p-value 0.03; combined p-value 1.9 × 10<sup>−4</sup>). Our study suggests a complex nature of the contribution of common genetic variants to risk for colorectal cancer.</p></div></front></TEI><pmc article-type="research-article" xml:lang="en"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">7613873</journal-id><journal-id journal-id-type="pubmed-jr-id">4137</journal-id><journal-id journal-id-type="nlm-ta">Hum Genet</journal-id><journal-title-group><journal-title>Human Genetics</journal-title></journal-title-group><issn pub-type="ppub">0340-6717</issn><issn pub-type="epub">1432-1203</issn></journal-meta><article-meta><article-id pub-id-type="pmid">21761138</article-id><article-id pub-id-type="pmc">3257356</article-id><article-id pub-id-type="doi">10.1007/s00439-011-1055-0</article-id><article-id pub-id-type="manuscript">NIHMS324653</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Meta-analysis of New Genome-wide Association Studies of Colorectal Cancer Risk</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Peters</surname><given-names>Ulrike</given-names></name><xref rid="A1" ref-type="aff">1</xref><xref rid="A2" ref-type="aff">2</xref><xref rid="FN2" ref-type="author-notes">*</xref></contrib><contrib contrib-type="author"><name><surname>Hutter</surname><given-names>Carolyn M.</given-names></name><xref rid="A1" ref-type="aff">1</xref><xref rid="FN2" ref-type="author-notes">*</xref></contrib><contrib contrib-type="author"><name><surname>Hsu</surname><given-names>Li</given-names></name><xref rid="A3" ref-type="aff">3</xref></contrib><contrib contrib-type="author"><name><surname>Schumacher</surname><given-names>Fredrick R.</given-names></name><xref rid="A4" ref-type="aff">4</xref></contrib><contrib contrib-type="author"><name><surname>Conti</surname><given-names>David V.</given-names></name><xref rid="A4" ref-type="aff">4</xref></contrib><contrib contrib-type="author"><name><surname>Carlson</surname><given-names>Christopher S.</given-names></name><xref rid="A1" ref-type="aff">1</xref></contrib><contrib contrib-type="author"><name><surname>Edlund</surname><given-names>Christopher K.</given-names></name><xref rid="A5" ref-type="aff">5</xref></contrib><contrib contrib-type="author"><name><surname>Haile</surname><given-names>Robert W.</given-names></name><xref rid="A4" ref-type="aff">4</xref></contrib><contrib contrib-type="author"><name><surname>Gallinger</surname><given-names>Steven</given-names></name><xref rid="A6" ref-type="aff">6</xref></contrib><contrib contrib-type="author"><name><surname>Zanke</surname><given-names>Brent W.</given-names></name><xref rid="A7" ref-type="aff">7</xref></contrib><contrib contrib-type="author"><name><surname>Lemire</surname><given-names>Mathieu</given-names></name><xref rid="A8" ref-type="aff">8</xref></contrib><contrib contrib-type="author"><name><surname>Rangrej</surname><given-names>Jagadish</given-names></name><xref rid="A8" ref-type="aff">8</xref></contrib><contrib contrib-type="author"><name><surname>Vijayaraghavan</surname><given-names>Raakhee</given-names></name><xref rid="A9" ref-type="aff">9</xref></contrib><contrib contrib-type="author"><name><surname>Chan</surname><given-names>Andrew T.</given-names></name><xref rid="A10" ref-type="aff">10</xref><xref rid="A11" ref-type="aff">11</xref></contrib><contrib contrib-type="author"><name><surname>Hazra</surname><given-names>Aditi</given-names></name><xref rid="A11" ref-type="aff">11</xref><xref rid="A12" ref-type="aff">12</xref></contrib><contrib contrib-type="author"><name><surname>Hunter</surname><given-names>David J.</given-names></name><xref rid="A12" ref-type="aff">12</xref></contrib><contrib contrib-type="author"><name><surname>Ma</surname><given-names>Jing</given-names></name><xref rid="A11" ref-type="aff">11</xref></contrib><contrib contrib-type="author"><name><surname>Fuchs</surname><given-names>Charles S.</given-names></name><xref rid="A11" ref-type="aff">11</xref><xref rid="A13" ref-type="aff">13</xref></contrib><contrib contrib-type="author"><name><surname>Giovannucci</surname><given-names>Edward L.</given-names></name><xref rid="A11" ref-type="aff">11</xref><xref rid="A14" ref-type="aff">14</xref></contrib><contrib contrib-type="author"><name><surname>Kraft</surname><given-names>Peter</given-names></name><xref rid="A12" ref-type="aff">12</xref></contrib><contrib contrib-type="author"><name><surname>Liu</surname><given-names>Yan</given-names></name><xref rid="A15" ref-type="aff">15</xref></contrib><contrib contrib-type="author"><name><surname>Chen</surname><given-names>Lin</given-names></name><xref rid="A16" ref-type="aff">16</xref></contrib><contrib contrib-type="author"><name><surname>Jiao</surname><given-names>Shuo</given-names></name><xref rid="A1" ref-type="aff">1</xref></contrib><contrib contrib-type="author"><name><surname>Makar</surname><given-names>Karen W.</given-names></name><xref rid="A1" ref-type="aff">1</xref></contrib><contrib contrib-type="author"><name><surname>Taverna</surname><given-names>Darin</given-names></name><xref rid="A9" ref-type="aff">9</xref></contrib><contrib contrib-type="author"><name><surname>Gruber</surname><given-names>Stephen B.</given-names></name><xref rid="A17" ref-type="aff">17</xref></contrib><contrib contrib-type="author"><name><surname>Rennert</surname><given-names>Gad</given-names></name><xref rid="A18" ref-type="aff">18</xref></contrib><contrib contrib-type="author"><name><surname>Moreno</surname><given-names>Victor</given-names></name><xref rid="A19" ref-type="aff">19</xref></contrib><contrib contrib-type="author"><name><surname>Ulrich</surname><given-names>Cornelia M.</given-names></name><xref rid="A1" ref-type="aff">1</xref><xref rid="A2" ref-type="aff">2</xref><xref rid="A20" ref-type="aff">20</xref></contrib><contrib contrib-type="author"><name><surname>Woods</surname><given-names>Michael O.</given-names></name><xref rid="A21" ref-type="aff">21</xref></contrib><contrib contrib-type="author"><name><surname>Green</surname><given-names>Roger C.</given-names></name><xref rid="A21" ref-type="aff">21</xref></contrib><contrib contrib-type="author"><name><surname>Parfrey</surname><given-names>Patrick S.</given-names></name><xref rid="A22" ref-type="aff">22</xref></contrib><contrib contrib-type="author"><name><surname>Prentice</surname><given-names>Ross L.</given-names></name><xref rid="A23" ref-type="aff">23</xref></contrib><contrib contrib-type="author"><name><surname>Kooperberg</surname><given-names>Charles</given-names></name><xref rid="A23" ref-type="aff">23</xref></contrib><contrib contrib-type="author"><name><surname>Jackson</surname><given-names>Rebecca D.</given-names></name><xref rid="A24" ref-type="aff">24</xref></contrib><contrib contrib-type="author"><name><surname>LaCroix</surname><given-names>Andrea Z.</given-names></name><xref rid="A1" ref-type="aff">1</xref></contrib><contrib contrib-type="author"><name><surname>Caan</surname><given-names>Bette J.</given-names></name><xref rid="A25" ref-type="aff">25</xref></contrib><contrib contrib-type="author"><name><surname>Hayes</surname><given-names>Richard B.</given-names></name><xref rid="A26" ref-type="aff">26</xref></contrib><contrib contrib-type="author"><name><surname>Berndt</surname><given-names>Sonja I.</given-names></name><xref rid="A27" ref-type="aff">27</xref></contrib><contrib contrib-type="author"><name><surname>Chanock</surname><given-names>Stephen J.</given-names></name><xref rid="A27" ref-type="aff">27</xref></contrib><contrib contrib-type="author"><name><surname>Schoen</surname><given-names>Robert E.</given-names></name><xref rid="A28" ref-type="aff">28</xref></contrib><contrib contrib-type="author"><name><surname>Chang-Claude</surname><given-names>Jenny</given-names></name><xref rid="A29" ref-type="aff">29</xref></contrib><contrib contrib-type="author"><name><surname>Hoffmeister</surname><given-names>Michael</given-names></name><xref rid="A30" ref-type="aff">30</xref></contrib><contrib contrib-type="author"><name><surname>Brenner</surname><given-names>Hermann</given-names></name><xref rid="A30" ref-type="aff">30</xref></contrib><contrib contrib-type="author"><name><surname>Frank</surname><given-names>Bernd</given-names></name><xref rid="A30" ref-type="aff">30</xref></contrib><contrib contrib-type="author"><name><surname>Bézieau</surname><given-names>Stéphane</given-names></name><xref rid="A31" ref-type="aff">31</xref></contrib><contrib contrib-type="author"><name><surname>Küry</surname><given-names>Sébastien</given-names></name><xref rid="A31" ref-type="aff">31</xref></contrib><contrib contrib-type="author"><name><surname>Slattery</surname><given-names>Martha L.</given-names></name><xref rid="A32" ref-type="aff">32</xref></contrib><contrib contrib-type="author"><name><surname>Hopper</surname><given-names>John L.</given-names></name><xref rid="A33" ref-type="aff">33</xref></contrib><contrib contrib-type="author"><name><surname>Jenkins</surname><given-names>Mark A.</given-names></name><xref rid="A33" ref-type="aff">33</xref></contrib><contrib contrib-type="author"><name><surname>Le Marchand</surname><given-names>Loic</given-names></name><xref rid="A34" ref-type="aff">34</xref></contrib><contrib contrib-type="author"><name><surname>Lindor</surname><given-names>Noralane M.</given-names></name><xref rid="A35" ref-type="aff">35</xref></contrib><contrib contrib-type="author"><name><surname>Newcomb</surname><given-names>Polly A.</given-names></name><xref rid="A1" ref-type="aff">1</xref></contrib><contrib contrib-type="author"><name><surname>Seminara</surname><given-names>Daniela</given-names></name><xref rid="A36" ref-type="aff">36</xref></contrib><contrib contrib-type="author"><name><surname>Hudson</surname><given-names>Thomas J.</given-names></name><xref rid="A8" ref-type="aff">8</xref><xref rid="A37" ref-type="aff">37</xref></contrib><contrib contrib-type="author"><name><surname>Duggan</surname><given-names>David J.</given-names></name><xref rid="A9" ref-type="aff">9</xref></contrib><contrib contrib-type="author"><name><surname>Potter</surname><given-names>John D.</given-names></name><xref rid="A2" ref-type="aff">2</xref><xref rid="A23" ref-type="aff">23</xref></contrib><contrib contrib-type="author"><name><surname>Casey</surname><given-names>Graham</given-names></name><xref rid="A4" ref-type="aff">4</xref></contrib><on-behalf-of>on behalf of CCFR</on-behalf-of><xref rid="A38" ref-type="aff">38</xref><on-behalf-of>GECCO</on-behalf-of><xref rid="A39" ref-type="aff">39</xref></contrib-group><aff id="A1"><label>1</label>Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, USA</aff><aff id="A2"><label>2</label>Department of Epidemiology, School of Public Health, University of Washington, Seattle, USA</aff><aff id="A3"><label>3</label>Biostatistics and Biomathematics, Fred Hutchinson Cancer Research Center, Seattle, USA</aff><aff id="A4"><label>4</label>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, USA</aff><aff id="A5"><label>5</label>Keck School of Medicine, University of Southern California, Los Angeles, USA</aff><aff id="A6"><label>6</label>Department of Surgery, University Health Network, Toronto General Hospital, Toronto, Canada</aff><aff id="A7"><label>7</label>Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Canada</aff><aff id="A8"><label>8</label>Ontario Institute for Cancer Research, Toronto, Canada</aff><aff id="A9"><label>9</label>Translational Genomics Research Institute, Phoenix, USA</aff><aff id="A10"><label>10</label>Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, USA</aff><aff id="A11"><label>11</label>Channing Laboratory, Brigham and Women’s Hospital and Harvard Medical School, Boston, USA</aff><aff id="A12"><label>12</label>Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, Boston, USA</aff><aff id="A13"><label>13</label>Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, USA</aff><aff id="A14"><label>14</label>Departments of Epidemiology and Nutrition, Harvard School of Public Health, Boston, USA</aff><aff id="A15"><label>15</label>Quantitative Services, Baylor Health Care System, Dallas, USA</aff><aff id="A16"><label>16</label>Department of Health Studies, University of Chicago, Chicago, USA</aff><aff id="A17"><label>17</label>Department of Internal Medicine, University of Michigan, Ann Arbor, USA</aff><aff id="A18"><label>18</label>Department of Community Medicine and Epidemiology, CarmelMedical Center and Technion Faculty of Medicine, Haifa, Israel</aff><aff id="A19"><label>19</label>Biostatistics and Bioinformatics Unit, Catalan Institute of Oncology-IDIBELL, Barcelona, Spain</aff><aff id="A20"><label>20</label>Division of Preventive Oncology, German Cancer Research Center, Heidelberg, Germany</aff><aff id="A21"><label>21</label>Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Canada</aff><aff id="A22"><label>22</label>Discipline of Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Canada</aff><aff id="A23"><label>23</label>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, USA</aff><aff id="A24"><label>24</label>Division of Endocrinology, Diabetes and Metabolism, Ohio State University, Columbus, USA</aff><aff id="A25"><label>25</label>Division of Research, Kaiser Permanente Medical Care Program, Oakland, USA</aff><aff id="A26"><label>26</label>Division of Epidemiology, Department of Environmental Medicine, New YorkUniversity School of Medicine, New York City, USA</aff><aff id="A27"><label>27</label>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, USA</aff><aff id="A28"><label>28</label>Department of Epidemiology, University of Pittsburgh Medical Center, Pittsburgh, USA</aff><aff id="A29"><label>29</label>Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany</aff><aff id="A30"><label>30</label>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany</aff><aff id="A31"><label>31</label>Centre Hospitalier Universitaire (CHU) de Nantes, Pôle de Biologie, Service de Génétique Médicale, Nantes, France</aff><aff id="A32"><label>32</label>Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, USA</aff><aff id="A33"><label>33</label>Centre for Molecular, Environmental, Genetic, and Analytical Epidemiology, University of Melbourne, Melbourne, Australia</aff><aff id="A34"><label>34</label>Epidemiology Program, Cancer Research Center of Hawai’i, University of Hawai’i at Manoa, Honolulu, USA</aff><aff id="A35"><label>35</label>Department of Medical Genetics, Mayo Clinic, Rochester, USA</aff><aff id="A36"><label>36</label>Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, USA</aff><aff id="A37"><label>37</label>Departments of Medical Biophysics and Molecular Genetics, University of Toronto, Toronto, Canada</aff><aff id="A38"><label>38</label>CCFR: Colon Cancer Family Registry</aff><aff id="A39"><label>39</label>GECCO: Genetics and Epidemiology of Colorectal Cancer Consortium</aff><author-notes><corresp id="FN1">Correspondence should be addressed to both: Ulrike Peters, <email>upeters@fhcrc.org</email>, Tel: +1 (206) 667-2450. Graham Casey, <email>gcasey@usc.edu</email>, Tel: +1 (323) 442-7865</corresp><fn id="FN2"><label>*</label><p>The authors wish it to be known that, in their opinion, the first two authors should be regarded as joint First Authors.</p></fn></author-notes><pub-date pub-type="nihms-submitted"><day>26</day><month>9</month><year>2011</year></pub-date><pub-date pub-type="epub"><day>15</day><month>7</month><year>2011</year></pub-date><pub-date pub-type="ppub"><month>2</month><year>2012</year></pub-date><pub-date pub-type="pmc-release"><day>1</day><month>2</month><year>2013</year></pub-date><volume>131</volume><issue>2</issue><fpage>217</fpage><lpage>234</lpage><abstract><p id="P1">Colorectal cancer is the second leading cause of cancer death in developed countries. Genome-wide association studies (GWAS) have successfully identified novel susceptibility loci for colorectal cancer. To follow-up on these findings, and try to identify novel colorectal cancer susceptibility loci, we present results for genome-wide association studies (GWAS) of colorectal cancer (2,906 cases, 3,416 controls) that have not previously published main associations. Specifically, we calculated odds ratios (ORs) and 95% confidence intervals (CIs) using log-additive models for each study. In order to improve our power to detect novel colorectal cancer susceptibility loci, we performed a meta-analysis combining the results across studies. We selected the most statistically significant single nucleotide polymorphisms (SNPs) for replication using 10 independent studies (8,161 cases and 9,101 controls). We again used a meta-analysis to summarize results for the replication studies alone, and for a combined analysis of GWAS and replication studies. We measured 10 SNPs previously identified in colorectal cancer susceptibility loci and found eight to be associated with colorectal cancer (p-value range: 0.02 to 1.8 × 10<sup>−8</sup>). When we excluded studies that have previously published on these SNPs, five SNPs remained significant at p<0.05 in the combined analysis. No novel susceptibility loci were significant in the replication study after adjustment for multiple testing, and none reached genome-wide significance from a combined analysis of GWAS and replication. We observed marginally significant evidence for a second independent SNP in the <italic>BMP2</italic> region at chromosomal location 20p12 (rs4813802; replication p-value 0.03; combined p-value 7.3 × 10<sup>−5</sup>). In a region on 5p33.15, which includes the coding regions of the <italic>TERT-CLPTM1L</italic> genes and has been identified in GWAS to be associated with susceptibility to at least seven other cancers, we observed a marginally significant association with rs2853668 (replication p-value 0.03; combined p-value 1.9 × 10<sup>−4</sup>). Our study suggests a complex nature of the contribution of common genetic variants to risk for colorectal cancer.</p></abstract><funding-group><award-group><funding-source country="United States">Women's Health Initiative : WHI</funding-source><award-id>N01 WH024152 || WH</award-id></award-group><award-group><funding-source country="United States">National Cancer Institute : NCI</funding-source><award-id>U24 CA074806-13 || CA</award-id></award-group><award-group><funding-source country="United States">National Cancer Institute : NCI</funding-source><award-id>U24 CA074800-13 || CA</award-id></award-group><award-group><funding-source country="United States">National Human Genome Research Institute : NHGRI</funding-source><award-id>U01 HG004446-04W1 || HG</award-id></award-group><award-group><funding-source country="United States">National Cancer Institute : NCI</funding-source><award-id>U01 CA137088-04 || CA</award-id></award-group><award-group><funding-source country="United States">National Cancer Institute : NCI</funding-source><award-id>U01 CA097735-05 || CA</award-id></award-group><award-group><funding-source country="United States">National Cancer Institute : NCI</funding-source><award-id>U01 CA074794-10 || CA</award-id></award-group><award-group><funding-source country="United States">National Cancer Institute : NCI</funding-source><award-id>U01 CA074783-09S2 || CA</award-id></award-group><award-group><funding-source country="United States">National Cancer Institute : NCI</funding-source><award-id>R25 CA094880-10 || CA</award-id></award-group><award-group><funding-source country="United States">National Cancer Institute : NCI</funding-source><award-id>R01 CA137178-04 || CA</award-id></award-group><award-group><funding-source country="United States">National Cancer Institute : NCI</funding-source><award-id>R01 CA081488-10 || CA</award-id></award-group><award-group><funding-source country="United States">National Cancer Institute : NCI</funding-source><award-id>R01 CA059045-14 || CA</award-id></award-group><award-group><funding-source country="United States">National Cancer Institute : NCI</funding-source><award-id>R01 CA048998-17 || CA</award-id></award-group><award-group><funding-source country="United States">National Cancer Institute : NCI</funding-source><award-id>P50 CA127003-05 || CA</award-id></award-group><award-group><funding-source country="United States">National Cancer Institute : NCI</funding-source><award-id>P01 CA087969-13 || CA</award-id></award-group><award-group><funding-source country="United States">National Cancer Institute : NCI</funding-source><award-id>P01 CA055075-17 || CA</award-id></award-group><award-group><funding-source country="United States">Women's Health Initiative : WHI</funding-source><award-id>N01 WH32115 || WH</award-id></award-group><award-group><funding-source country="United States">Women's Health Initiative : WHI</funding-source><award-id>N01 WH044221 || WH</award-id></award-group><award-group><funding-source country="United States">Women's Health Initiative : WHI</funding-source><award-id>N01 WH042129 || WH</award-id></award-group><award-group><funding-source country="United States">Women's Health Initiative : WHI</funding-source><award-id>N01 WH042116 || WH</award-id></award-group><award-group><funding-source country="United States">Women's Health Initiative : WHI</funding-source><award-id>N01 WH042114 || WH</award-id></award-group><award-group><funding-source country="United States">Women's Health Initiative : WHI</funding-source><award-id>N01 WH042112 || WH</award-id></award-group><award-group><funding-source country="United States">Women's Health Initiative : WHI</funding-source><award-id>N01 WH042107 || WH</award-id></award-group><award-group><funding-source country="United States">Women's Health Initiative : WHI</funding-source><award-id>N01 WH032122 || WH</award-id></award-group><award-group><funding-source country="United States">Women's Health Initiative : WHI</funding-source><award-id>N01 WH032119 || WH</award-id></award-group><award-group><funding-source country="United States">Women's Health Initiative : WHI</funding-source><award-id>N01 WH032118 || WH</award-id></award-group><award-group><funding-source country="United States">Women's Health Initiative : WHI</funding-source><award-id>N01 WH032111 || WH</award-id></award-group><award-group><funding-source country="United States">Women's Health Initiative : WHI</funding-source><award-id>N01 WH032108 || WH</award-id></award-group><award-group><funding-source country="United States">Women's Health Initiative : WHI</funding-source><award-id>N01 WH032105 || WH</award-id></award-group><award-group><funding-source country="United States">Women's Health Initiative : WHI</funding-source><award-id>N01 WH032100 || WH</award-id></award-group><award-group><funding-source country="United States">Division of Cancer Epidemiology and Genetics : NCI</funding-source><award-id>Z01 CP010200-03 || CP</award-id></award-group></funding-group></article-meta></front></pmc><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Canada</li><li>Espagne</li><li>France</li><li>Israël</li><li>États-Unis</li></country><region><li>Bade-Wurtemberg</li><li>Californie</li><li>Catalogne</li><li>District de Karlsruhe</li><li>Illinois</li><li>Massachusetts</li><li>Ontario</li><li>Pays de la Loire</li><li>Pennsylvanie</li><li>Texas</li><li>Victoria (État)</li><li>Washington (État)</li><li>État de New York</li></region><settlement><li>Barcelone</li><li>Boston</li><li>Chicago</li><li>Dallas</li><li>Heidelberg</li><li>Los Angeles</li><li>Melbourne</li><li>Nantes</li><li>New York</li><li>Pittsburgh</li><li>Seattle</li><li>Toronto</li></settlement><orgName><li>Université de Californie du Sud</li><li>Université de Melbourne</li><li>Université de Toronto</li><li>Université de Washington</li></orgName></list><tree><country name="États-Unis"><noRegion><name sortKey="Peters, Ulrike" sort="Peters, Ulrike" uniqKey="Peters U" first="Ulrike" last="Peters">Ulrike Peters</name></noRegion><name sortKey="Berndt, Sonja I" sort="Berndt, Sonja I" uniqKey="Berndt S" first="Sonja I." last="Berndt">Sonja I. Berndt</name><name sortKey="Caan, Bette J" sort="Caan, Bette J" uniqKey="Caan B" first="Bette J." last="Caan">Bette J. Caan</name><name sortKey="Carlson, Christopher S" sort="Carlson, Christopher S" uniqKey="Carlson C" first="Christopher S." last="Carlson">Christopher S. Carlson</name><name sortKey="Casey, Graham" sort="Casey, Graham" uniqKey="Casey G" first="Graham" last="Casey">Graham Casey</name><name sortKey="Chan, Andrew T" sort="Chan, Andrew T" uniqKey="Chan A" first="Andrew T." last="Chan">Andrew T. Chan</name><name sortKey="Chan, Andrew T" sort="Chan, Andrew T" uniqKey="Chan A" first="Andrew T." last="Chan">Andrew T. Chan</name><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J." last="Chanock">Stephen J. Chanock</name><name sortKey="Chen, Lin" sort="Chen, Lin" uniqKey="Chen L" first="Lin" last="Chen">Lin Chen</name><name sortKey="Conti, David V" sort="Conti, David V" uniqKey="Conti D" first="David V." last="Conti">David V. Conti</name><name sortKey="Duggan, David J" sort="Duggan, David J" uniqKey="Duggan D" first="David J." last="Duggan">David J. Duggan</name><name sortKey="Edlund, Christopher K" sort="Edlund, Christopher K" uniqKey="Edlund C" first="Christopher K." last="Edlund">Christopher K. Edlund</name><name sortKey="Fuchs, Charles S" sort="Fuchs, Charles S" uniqKey="Fuchs C" first="Charles S." last="Fuchs">Charles S. Fuchs</name><name sortKey="Fuchs, Charles S" sort="Fuchs, Charles S" uniqKey="Fuchs C" first="Charles S." last="Fuchs">Charles S. Fuchs</name><name sortKey="Giovannucci, Edward L" sort="Giovannucci, Edward L" uniqKey="Giovannucci E" first="Edward L." last="Giovannucci">Edward L. Giovannucci</name><name sortKey="Giovannucci, Edward L" sort="Giovannucci, Edward L" uniqKey="Giovannucci E" first="Edward L." last="Giovannucci">Edward L. Giovannucci</name><name sortKey="Gruber, Stephen B" sort="Gruber, Stephen B" uniqKey="Gruber S" first="Stephen B." last="Gruber">Stephen B. Gruber</name><name sortKey="Haile, Robert W" sort="Haile, Robert W" uniqKey="Haile R" first="Robert W." last="Haile">Robert W. Haile</name><name sortKey="Hayes, Richard B" sort="Hayes, Richard B" uniqKey="Hayes R" first="Richard B." last="Hayes">Richard B. Hayes</name><name sortKey="Hazra, Aditi" sort="Hazra, Aditi" uniqKey="Hazra A" first="Aditi" last="Hazra">Aditi Hazra</name><name sortKey="Hazra, Aditi" sort="Hazra, Aditi" uniqKey="Hazra A" first="Aditi" last="Hazra">Aditi Hazra</name><name sortKey="Hsu, Li" sort="Hsu, Li" uniqKey="Hsu L" first="Li" last="Hsu">Li Hsu</name><name sortKey="Hunter, David J" sort="Hunter, David J" uniqKey="Hunter D" first="David J." last="Hunter">David J. Hunter</name><name sortKey="Hutter, Carolyn M" sort="Hutter, Carolyn M" uniqKey="Hutter C" first="Carolyn M." last="Hutter">Carolyn M. Hutter</name><name sortKey="Jackson, Rebecca D" sort="Jackson, Rebecca D" uniqKey="Jackson R" first="Rebecca D." last="Jackson">Rebecca D. Jackson</name><name sortKey="Jiao, Shuo" sort="Jiao, Shuo" uniqKey="Jiao S" first="Shuo" last="Jiao">Shuo Jiao</name><name sortKey="Kooperberg, Charles" sort="Kooperberg, Charles" uniqKey="Kooperberg C" first="Charles" last="Kooperberg">Charles Kooperberg</name><name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name><name sortKey="Lacroix, Andrea Z" sort="Lacroix, Andrea Z" uniqKey="Lacroix A" first="Andrea Z." last="Lacroix">Andrea Z. Lacroix</name><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loic" last="Le Marchand">Loic Le Marchand</name><name sortKey="Lindor, Noralane M" sort="Lindor, Noralane M" uniqKey="Lindor N" first="Noralane M." last="Lindor">Noralane M. Lindor</name><name sortKey="Liu, Yan" sort="Liu, Yan" uniqKey="Liu Y" first="Yan" last="Liu">Yan Liu</name><name sortKey="Ma, Jing" sort="Ma, Jing" uniqKey="Ma J" first="Jing" last="Ma">Jing Ma</name><name sortKey="Makar, Karen W" sort="Makar, Karen W" uniqKey="Makar K" first="Karen W." last="Makar">Karen W. Makar</name><name sortKey="Newcomb, Polly A" sort="Newcomb, Polly A" uniqKey="Newcomb P" first="Polly A." last="Newcomb">Polly A. Newcomb</name><name sortKey="Peters, Ulrike" sort="Peters, Ulrike" uniqKey="Peters U" first="Ulrike" last="Peters">Ulrike Peters</name><name sortKey="Potter, John D" sort="Potter, John D" uniqKey="Potter J" first="John D." last="Potter">John D. Potter</name><name sortKey="Potter, John D" sort="Potter, John D" uniqKey="Potter J" first="John D." last="Potter">John D. Potter</name><name sortKey="Prentice, Ross L" sort="Prentice, Ross L" uniqKey="Prentice R" first="Ross L." last="Prentice">Ross L. Prentice</name><name sortKey="Schoen, Robert E" sort="Schoen, Robert E" uniqKey="Schoen R" first="Robert E." last="Schoen">Robert E. Schoen</name><name sortKey="Schumacher, Fredrick R" sort="Schumacher, Fredrick R" uniqKey="Schumacher F" first="Fredrick R." last="Schumacher">Fredrick R. Schumacher</name><name sortKey="Seminara, Daniela" sort="Seminara, Daniela" uniqKey="Seminara D" first="Daniela" last="Seminara">Daniela Seminara</name><name sortKey="Slattery, Martha L" sort="Slattery, Martha L" uniqKey="Slattery M" first="Martha L." last="Slattery">Martha L. Slattery</name><name sortKey="Taverna, Darin" sort="Taverna, Darin" uniqKey="Taverna D" first="Darin" last="Taverna">Darin Taverna</name><name sortKey="Ulrich, Cornelia M" sort="Ulrich, Cornelia M" uniqKey="Ulrich C" first="Cornelia M." last="Ulrich">Cornelia M. Ulrich</name><name sortKey="Ulrich, Cornelia M" sort="Ulrich, Cornelia M" uniqKey="Ulrich C" first="Cornelia M." last="Ulrich">Cornelia M. Ulrich</name><name sortKey="Vijayaraghavan, Raakhee" sort="Vijayaraghavan, Raakhee" uniqKey="Vijayaraghavan R" first="Raakhee" last="Vijayaraghavan">Raakhee Vijayaraghavan</name></country><country name="Canada"><noRegion><name sortKey="Gallinger, Steven" sort="Gallinger, Steven" uniqKey="Gallinger S" first="Steven" last="Gallinger">Steven Gallinger</name></noRegion><name sortKey="Green, Roger C" sort="Green, Roger C" uniqKey="Green R" first="Roger C." last="Green">Roger C. Green</name><name sortKey="Hudson, Thomas J" sort="Hudson, Thomas J" uniqKey="Hudson T" first="Thomas J." last="Hudson">Thomas J. Hudson</name><name sortKey="Hudson, Thomas J" sort="Hudson, Thomas J" uniqKey="Hudson T" first="Thomas J." last="Hudson">Thomas J. Hudson</name><name sortKey="Lemire, Mathieu" sort="Lemire, Mathieu" uniqKey="Lemire M" first="Mathieu" last="Lemire">Mathieu Lemire</name><name sortKey="Parfrey, Patrick S" sort="Parfrey, Patrick S" uniqKey="Parfrey P" first="Patrick S." last="Parfrey">Patrick S. Parfrey</name><name sortKey="Rangrej, Jagadish" sort="Rangrej, Jagadish" uniqKey="Rangrej J" first="Jagadish" last="Rangrej">Jagadish Rangrej</name><name sortKey="Woods, Michael O" sort="Woods, Michael O" uniqKey="Woods M" first="Michael O." last="Woods">Michael O. Woods</name><name sortKey="Zanke, Brent W" sort="Zanke, Brent W" uniqKey="Zanke B" first="Brent W." last="Zanke">Brent W. Zanke</name></country><country name="Israël"><noRegion><name sortKey="Rennert, Gad" sort="Rennert, Gad" uniqKey="Rennert G" first="Gad" last="Rennert">Gad Rennert</name></noRegion></country><country name="Espagne"><region name="Catalogne"><name sortKey="Moreno, Victor" sort="Moreno, Victor" uniqKey="Moreno V" first="Victor" last="Moreno">Victor Moreno</name></region></country><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Ulrich, Cornelia M" sort="Ulrich, Cornelia M" uniqKey="Ulrich C" first="Cornelia M." last="Ulrich">Cornelia M. Ulrich</name></region><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name><name sortKey="Frank, Bernd" sort="Frank, Bernd" uniqKey="Frank B" first="Bernd" last="Frank">Bernd Frank</name><name sortKey="Hoffmeister, Michael" sort="Hoffmeister, Michael" uniqKey="Hoffmeister M" first="Michael" last="Hoffmeister">Michael Hoffmeister</name></country><country name="France"><region name="Pays de la Loire"><name sortKey="Bezieau, Stephane" sort="Bezieau, Stephane" uniqKey="Bezieau S" first="Stéphane" last="Bézieau">Stéphane Bézieau</name></region><name sortKey="Kury, Sebastien" sort="Kury, Sebastien" uniqKey="Kury S" first="Sébastien" last="Küry">Sébastien Küry</name></country><country name="Australie"><region name="Victoria (État)"><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name></region><name sortKey="Jenkins, Mark A" sort="Jenkins, Mark A" uniqKey="Jenkins M" first="Mark A." last="Jenkins">Mark A. Jenkins</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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