AustralieFrV1, PascalFrancis, Corpus, bibRecord, 002697

The Framingham and UK Prospective Diabetes Study (UKPDS) risk equations do not reliably estimate the probability of cardiovascular events in a large ethnically diverse sample of patients with diabetes: the Action in Diabetes and Vascular Disease: Preterax and Diamicron-MR Controlled Evaluation (ADVANCE) Study

Identifieur interne : 002697 ( PascalFrancis/Corpus ); précédent : 002696; suivant : 002698

The Framingham and UK Prospective Diabetes Study (UKPDS) risk equations do not reliably estimate the probability of cardiovascular events in a large ethnically diverse sample of patients with diabetes: the Action in Diabetes and Vascular Disease: Preterax and Diamicron-MR Controlled Evaluation (ADVANCE) Study

Auteurs : A. P. Kengne ; A. Patel ; S. Colagiuri ; S. Heller ; P. Hamet ; M. Marre ; C. Y. Pan ; S. Zoungas ; D. E. Grobbee ; B. Neal ; J. Chalmers ; M. Woodward

Source :

Diabetologia : (Berlin) [ 0012-186X ] ; 2010.

RBID : Pascal:10-0239448

Descripteurs français

Pascal (Inist)
- Prospective, Facteur risque, Pathologie des vaisseaux sanguins, Evaluation, Pathologie de l'appareil circulatoire, Discrimination, Diabète, Prédiction, Homme.

English descriptors

KwdEn :
- Cardiovascular disease, Diabetes mellitus, Discrimination, Evaluation, Human, Prediction, Prospective, Risk factor, Vascular disease.

Abstract

Aims/hypothesis Available multivariable equations for cardiovascular risk assessment in people with diabetes have been derived either from the general population or from populations with diabetes. Their utility and comparative performance in a contemporary group of patients with type 2 diabetes are not well established. The aim of this study was to evaluate the performance of the Framingham and UK Prospective Diabetes Study (UKPDS) risk equations in participants who took part in the Action in Diabetes and Vascular disease: Preterax and Diamicron-MR Controlled Evaluation (ADVANCE) trial. Methods The 4-year risks of cardiovascular disease (CVD) and its constituents were estimated using two published Framingham and the UKPDS risk equations in 7,502 individuals with type 2 diabetes without prior known CVD at their enrolment in the trial. Results The risk of major CVD was overestimated by 170% (95% CI 146-195%) and 202% (176-231%) using the two Framingham equations. The risk of major coronary heart disease was overestimated by 198% (162-238%) with the UKPDS, and by 146% (117-179%) and 289% (243-341%) with the two different Framingham equations, respectively. The risks of stroke events were also overestimated with the UKPDS and one of the Framingham equations. The ability of these equations to rank risk among ADVANCE participants was modest, with c-statistics ranging from 0.57 to 0.71. Results stratified by sex, treatment allocation and ethnicity were broadly similar. Conclusions/interpretation Application of the Framingham and UKPDS risk equations to a contemporary treated group of patients with established type 2 diabetes is likely to substantially overestimate cardiovascular risk.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

A01	`01`	`1`		`@0 0012-186X`
A03		`1`		`@0 Diabetologia : (Berl.)`
A05				`@2 53`
A06				`@2 5`
A08	`01`	`1`	`ENG`	`@1 The Framingham and UK Prospective Diabetes Study (UKPDS) risk equations do not reliably estimate the probability of cardiovascular events in a large ethnically diverse sample of patients with diabetes: the Action in Diabetes and Vascular Disease: Preterax and Diamicron-MR Controlled Evaluation (ADVANCE) Study`
A11	`01`	`1`		`@1 KENGNE (A. P.)`
A11	`02`	`1`		`@1 PATEL (A.)`
A11	`03`	`1`		`@1 COLAGIURI (S.)`
A11	`04`	`1`		`@1 HELLER (S.)`
A11	`05`	`1`		`@1 HAMET (P.)`
A11	`06`	`1`		`@1 MARRE (M.)`
A11	`07`	`1`		`@1 PAN (C. Y.)`
A11	`08`	`1`		`@1 ZOUNGAS (S.)`
A11	`09`	`1`		`@1 GROBBEE (D. E.)`
A11	`10`	`1`		`@1 NEAL (B.)`
A11	`11`	`1`		`@1 CHALMERS (J.)`
A11	`12`	`1`		`@1 WOODWARD (M.)`
A14	`01`			`@1 The George Institute for International Health, University of Sydney, PO Box M201, Level 10 KGV Building, RPAH, Missenden Road, Camperdown @2 Sydney, NSW 2050 @3 AUS @Z 1 aut. @Z 2 aut. @Z 8 aut. @Z 10 aut. @Z 11 aut. @Z 12 aut.`
A14	`02`			`@1 Institute of Obesity, Nutrition and Exercise, Faculty of Medicine, The University of Sydney @2 Sydney, NSW @3 AUS @Z 3 aut.`
A14	`03`			`@1 University of Sheffield and Sheffield Teaching Hospitals National Health Service (NHS) Foundation Trust @2 Sheffield @3 GBR @Z 4 aut.`
A14	`04`			`@1 Centre Hospitalier de l'Université de Montréal, Université de Montréal @2 Montréal, QC @3 CAN @Z 5 aut.`
A14	`05`			`@1 Hôpital Bichat-Claude Bernard and Université Paris 7 @2 Paris @3 FRA @Z 6 aut.`
A14	`06`			`@1 Chinese People's Liberation Army General Hospital @2 Beijing @3 CHN @Z 7 aut.`
A14	`07`			`@1 School of Public Health, Monash University @2 Melbourne, Victoria @3 AUS @Z 8 aut.`
A14	`08`			`@1 Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht @2 Utrecht @3 NLD @Z 9 aut.`
A14	`09`			`@1 Mount Sinai School of Medicine @2 New York, NY @3 USA @Z 12 aut.`
A17	`01`	`1`		`@1 ADVANCE Collaborative Group @3 INC`
A20				`@1 821-831`
A21				`@1 2010`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 13012 @5 354000181063030040`
A44				`@0 0000 @1 © 2010 INIST-CNRS. All rights reserved.`
A45				`@0 37 ref.`
A47	`01`	`1`		`@0 10-0239448`
A60				`@1 P`
A61				`@0 A`
A64	`01`	`1`		`@0 Diabetologia : (Berlin)`
A66	`01`			`@0 DEU`
C01	`01`		`ENG`	@0 Aims/hypothesis Available multivariable equations for cardiovascular risk assessment in people with diabetes have been derived either from the general population or from populations with diabetes. Their utility and comparative performance in a contemporary group of patients with type 2 diabetes are not well established. The aim of this study was to evaluate the performance of the Framingham and UK Prospective Diabetes Study (UKPDS) risk equations in participants who took part in the Action in Diabetes and Vascular disease: Preterax and Diamicron-MR Controlled Evaluation (ADVANCE) trial. Methods The 4-year risks of cardiovascular disease (CVD) and its constituents were estimated using two published Framingham and the UKPDS risk equations in 7,502 individuals with type 2 diabetes without prior known CVD at their enrolment in the trial. Results The risk of major CVD was overestimated by 170% (95% CI 146-195%) and 202% (176-231%) using the two Framingham equations. The risk of major coronary heart disease was overestimated by 198% (162-238%) with the UKPDS, and by 146% (117-179%) and 289% (243-341%) with the two different Framingham equations, respectively. The risks of stroke events were also overestimated with the UKPDS and one of the Framingham equations. The ability of these equations to rank risk among ADVANCE participants was modest, with c-statistics ranging from 0.57 to 0.71. Results stratified by sex, treatment allocation and ethnicity were broadly similar. Conclusions/interpretation Application of the Framingham and UKPDS risk equations to a contemporary treated group of patients with established type 2 diabetes is likely to substantially overestimate cardiovascular risk.
C02	`01`	`X`		`@0 002B21E01A`
C03	`01`	`X`	`FRE`	`@0 Prospective @5 01`
C03	`01`	`X`	`ENG`	`@0 Prospective @5 01`
C03	`01`	`X`	`SPA`	`@0 Prospectiva @5 01`
C03	`02`	`X`	`FRE`	`@0 Facteur risque @5 02`
C03	`02`	`X`	`ENG`	`@0 Risk factor @5 02`
C03	`02`	`X`	`SPA`	`@0 Factor riesgo @5 02`
C03	`03`	`X`	`FRE`	`@0 Pathologie des vaisseaux sanguins @5 03`
C03	`03`	`X`	`ENG`	`@0 Vascular disease @5 03`
C03	`03`	`X`	`SPA`	`@0 Vaso sanguíneo patología @5 03`
C03	`04`	`X`	`FRE`	`@0 Evaluation @5 04`
C03	`04`	`X`	`ENG`	`@0 Evaluation @5 04`
C03	`04`	`X`	`SPA`	`@0 Evaluación @5 04`
C03	`05`	`X`	`FRE`	`@0 Pathologie de l'appareil circulatoire @5 07`
C03	`05`	`X`	`ENG`	`@0 Cardiovascular disease @5 07`
C03	`05`	`X`	`SPA`	`@0 Aparato circulatorio patología @5 07`
C03	`06`	`X`	`FRE`	`@0 Discrimination @5 08`
C03	`06`	`X`	`ENG`	`@0 Discrimination @5 08`
C03	`06`	`X`	`SPA`	`@0 Discriminación @5 08`
C03	`07`	`X`	`FRE`	`@0 Diabète @2 NM @5 09`
C03	`07`	`X`	`ENG`	`@0 Diabetes mellitus @2 NM @5 09`
C03	`07`	`X`	`SPA`	`@0 Diabetes @2 NM @5 09`
C03	`08`	`X`	`FRE`	`@0 Prédiction @5 13`
C03	`08`	`X`	`ENG`	`@0 Prediction @5 13`
C03	`08`	`X`	`SPA`	`@0 Predicción @5 13`
C03	`09`	`X`	`FRE`	`@0 Homme @5 72`
C03	`09`	`X`	`ENG`	`@0 Human @5 72`
C03	`09`	`X`	`SPA`	`@0 Hombre @5 72`
C07	`01`	`X`	`FRE`	`@0 Endocrinopathie @5 20`
C07	`01`	`X`	`ENG`	`@0 Endocrinopathy @5 20`
C07	`01`	`X`	`SPA`	`@0 Endocrinopatía @5 20`
N21				`@1 158`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

Format Inist (serveur)

NO :	PASCAL 10-0239448 INIST
ET :	The Framingham and UK Prospective Diabetes Study (UKPDS) risk equations do not reliably estimate the probability of cardiovascular events in a large ethnically diverse sample of patients with diabetes: the Action in Diabetes and Vascular Disease: Preterax and Diamicron-MR Controlled Evaluation (ADVANCE) Study
AU :	KENGNE (A. P.); PATEL (A.); COLAGIURI (S.); HELLER (S.); HAMET (P.); MARRE (M.); PAN (C. Y.); ZOUNGAS (S.); GROBBEE (D. E.); NEAL (B.); CHALMERS (J.); WOODWARD (M.)
AF :	The George Institute for International Health, University of Sydney, PO Box M201, Level 10 KGV Building, RPAH, Missenden Road, Camperdown/Sydney, NSW 2050/Australie (1 aut., 2 aut., 8 aut., 10 aut., 11 aut., 12 aut.); Institute of Obesity, Nutrition and Exercise, Faculty of Medicine, The University of Sydney/Sydney, NSW/Australie (3 aut.); University of Sheffield and Sheffield Teaching Hospitals National Health Service (NHS) Foundation Trust/Sheffield/Royaume-Uni (4 aut.); Centre Hospitalier de l'Université de Montréal, Université de Montréal/Montréal, QC/Canada (5 aut.); Hôpital Bichat-Claude Bernard and Université Paris 7/Paris/France (6 aut.); Chinese People's Liberation Army General Hospital/Beijing/Chine (7 aut.); School of Public Health, Monash University/Melbourne, Victoria/Australie (8 aut.); Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht/Utrecht/Pays-Bas (9 aut.); Mount Sinai School of Medicine/New York, NY/Etats-Unis (12 aut.)
DT :	Publication en série; Niveau analytique
SO :	Diabetologia : (Berlin); ISSN 0012-186X; Allemagne; Da. 2010; Vol. 53; No. 5; Pp. 821-831; Bibl. 37 ref.
LA :	Anglais
EA :	Aims/hypothesis Available multivariable equations for cardiovascular risk assessment in people with diabetes have been derived either from the general population or from populations with diabetes. Their utility and comparative performance in a contemporary group of patients with type 2 diabetes are not well established. The aim of this study was to evaluate the performance of the Framingham and UK Prospective Diabetes Study (UKPDS) risk equations in participants who took part in the Action in Diabetes and Vascular disease: Preterax and Diamicron-MR Controlled Evaluation (ADVANCE) trial. Methods The 4-year risks of cardiovascular disease (CVD) and its constituents were estimated using two published Framingham and the UKPDS risk equations in 7,502 individuals with type 2 diabetes without prior known CVD at their enrolment in the trial. Results The risk of major CVD was overestimated by 170% (95% CI 146-195%) and 202% (176-231%) using the two Framingham equations. The risk of major coronary heart disease was overestimated by 198% (162-238%) with the UKPDS, and by 146% (117-179%) and 289% (243-341%) with the two different Framingham equations, respectively. The risks of stroke events were also overestimated with the UKPDS and one of the Framingham equations. The ability of these equations to rank risk among ADVANCE participants was modest, with c-statistics ranging from 0.57 to 0.71. Results stratified by sex, treatment allocation and ethnicity were broadly similar. Conclusions/interpretation Application of the Framingham and UKPDS risk equations to a contemporary treated group of patients with established type 2 diabetes is likely to substantially overestimate cardiovascular risk.
CC :	002B21E01A
FD :	Prospective; Facteur risque; Pathologie des vaisseaux sanguins; Evaluation; Pathologie de l'appareil circulatoire; Discrimination; Diabète; Prédiction; Homme
FG :	Endocrinopathie
ED :	Prospective; Risk factor; Vascular disease; Evaluation; Cardiovascular disease; Discrimination; Diabetes mellitus; Prediction; Human
EG :	Endocrinopathy
SD :	Prospectiva; Factor riesgo; Vaso sanguíneo patología; Evaluación; Aparato circulatorio patología; Discriminación; Diabetes; Predicción; Hombre
LO :	INIST-13012.354000181063030040
ID :	10-0239448

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Pascal:10-0239448

Le document en format XML

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<affiliation><inist:fA14 i1="07"><s1>School of Public Health, Monash University</s1>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">The Framingham and UK Prospective Diabetes Study (UKPDS) risk equations do not reliably estimate the probability of cardiovascular events in a large ethnically diverse sample of patients with diabetes: the Action in Diabetes and Vascular Disease: Preterax and Diamicron-MR Controlled Evaluation (ADVANCE) Study</title>
<author><name sortKey="Kengne, A P" sort="Kengne, A P" uniqKey="Kengne A" first="A. P." last="Kengne">A. P. Kengne</name>
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<author><name sortKey="Patel, A" sort="Patel, A" uniqKey="Patel A" first="A." last="Patel">A. Patel</name>
<affiliation><inist:fA14 i1="01"><s1>The George Institute for International Health, University of Sydney, PO Box M201, Level 10 KGV Building, RPAH, Missenden Road, Camperdown</s1>
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<author><name sortKey="Colagiuri, S" sort="Colagiuri, S" uniqKey="Colagiuri S" first="S." last="Colagiuri">S. Colagiuri</name>
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<s2>Sydney, NSW</s2>
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<author><name sortKey="Heller, S" sort="Heller, S" uniqKey="Heller S" first="S." last="Heller">S. Heller</name>
<affiliation><inist:fA14 i1="03"><s1>University of Sheffield and Sheffield Teaching Hospitals National Health Service (NHS) Foundation Trust</s1>
<s2>Sheffield</s2>
<s3>GBR</s3>
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<author><name sortKey="Hamet, P" sort="Hamet, P" uniqKey="Hamet P" first="P." last="Hamet">P. Hamet</name>
<affiliation><inist:fA14 i1="04"><s1>Centre Hospitalier de l'Université de Montréal, Université de Montréal</s1>
<s2>Montréal, QC</s2>
<s3>CAN</s3>
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</inist:fA14>
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</author>
<author><name sortKey="Marre, M" sort="Marre, M" uniqKey="Marre M" first="M." last="Marre">M. Marre</name>
<affiliation><inist:fA14 i1="05"><s1>Hôpital Bichat-Claude Bernard and Université Paris 7</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
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<author><name sortKey="Pan, C Y" sort="Pan, C Y" uniqKey="Pan C" first="C. Y." last="Pan">C. Y. Pan</name>
<affiliation><inist:fA14 i1="06"><s1>Chinese People's Liberation Army General Hospital</s1>
<s2>Beijing</s2>
<s3>CHN</s3>
<sZ>7 aut.</sZ>
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<author><name sortKey="Zoungas, S" sort="Zoungas, S" uniqKey="Zoungas S" first="S." last="Zoungas">S. Zoungas</name>
<affiliation><inist:fA14 i1="01"><s1>The George Institute for International Health, University of Sydney, PO Box M201, Level 10 KGV Building, RPAH, Missenden Road, Camperdown</s1>
<s2>Sydney, NSW 2050</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
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<affiliation><inist:fA14 i1="07"><s1>School of Public Health, Monash University</s1>
<s2>Melbourne, Victoria</s2>
<s3>AUS</s3>
<sZ>8 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Grobbee, D E" sort="Grobbee, D E" uniqKey="Grobbee D" first="D. E." last="Grobbee">D. E. Grobbee</name>
<affiliation><inist:fA14 i1="08"><s1>Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht</s1>
<s2>Utrecht</s2>
<s3>NLD</s3>
<sZ>9 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Neal, B" sort="Neal, B" uniqKey="Neal B" first="B." last="Neal">B. Neal</name>
<affiliation><inist:fA14 i1="01"><s1>The George Institute for International Health, University of Sydney, PO Box M201, Level 10 KGV Building, RPAH, Missenden Road, Camperdown</s1>
<s2>Sydney, NSW 2050</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
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</author>
<author><name sortKey="Chalmers, J" sort="Chalmers, J" uniqKey="Chalmers J" first="J." last="Chalmers">J. Chalmers</name>
<affiliation><inist:fA14 i1="01"><s1>The George Institute for International Health, University of Sydney, PO Box M201, Level 10 KGV Building, RPAH, Missenden Road, Camperdown</s1>
<s2>Sydney, NSW 2050</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>10 aut.</sZ>
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<author><name sortKey="Woodward, M" sort="Woodward, M" uniqKey="Woodward M" first="M." last="Woodward">M. Woodward</name>
<affiliation><inist:fA14 i1="01"><s1>The George Institute for International Health, University of Sydney, PO Box M201, Level 10 KGV Building, RPAH, Missenden Road, Camperdown</s1>
<s2>Sydney, NSW 2050</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
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</affiliation>
<affiliation><inist:fA14 i1="09"><s1>Mount Sinai School of Medicine</s1>
<s2>New York, NY</s2>
<s3>USA</s3>
<sZ>12 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Diabetologia : (Berlin)</title>
<title level="j" type="abbreviated">Diabetologia : (Berl.)</title>
<idno type="ISSN">0012-186X</idno>
<imprint><date when="2010">2010</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Diabetologia : (Berlin)</title>
<title level="j" type="abbreviated">Diabetologia : (Berl.)</title>
<idno type="ISSN">0012-186X</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cardiovascular disease</term>
<term>Diabetes mellitus</term>
<term>Discrimination</term>
<term>Evaluation</term>
<term>Human</term>
<term>Prediction</term>
<term>Prospective</term>
<term>Risk factor</term>
<term>Vascular disease</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Prospective</term>
<term>Facteur risque</term>
<term>Pathologie des vaisseaux sanguins</term>
<term>Evaluation</term>
<term>Pathologie de l'appareil circulatoire</term>
<term>Discrimination</term>
<term>Diabète</term>
<term>Prédiction</term>
<term>Homme</term>
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<front><div type="abstract" xml:lang="en">Aims/hypothesis Available multivariable equations for cardiovascular risk assessment in people with diabetes have been derived either from the general population or from populations with diabetes. Their utility and comparative performance in a contemporary group of patients with type 2 diabetes are not well established. The aim of this study was to evaluate the performance of the Framingham and UK Prospective Diabetes Study (UKPDS) risk equations in participants who took part in the Action in Diabetes and Vascular disease: Preterax and Diamicron-MR Controlled Evaluation (ADVANCE) trial. Methods The 4-year risks of cardiovascular disease (CVD) and its constituents were estimated using two published Framingham and the UKPDS risk equations in 7,502 individuals with type 2 diabetes without prior known CVD at their enrolment in the trial. Results The risk of major CVD was overestimated by 170% (95% CI 146-195%) and 202% (176-231%) using the two Framingham equations. The risk of major coronary heart disease was overestimated by 198% (162-238%) with the UKPDS, and by 146% (117-179%) and 289% (243-341%) with the two different Framingham equations, respectively. The risks of stroke events were also overestimated with the UKPDS and one of the Framingham equations. The ability of these equations to rank risk among ADVANCE participants was modest, with c-statistics ranging from 0.57 to 0.71. Results stratified by sex, treatment allocation and ethnicity were broadly similar. Conclusions/interpretation Application of the Framingham and UKPDS risk equations to a contemporary treated group of patients with established type 2 diabetes is likely to substantially overestimate cardiovascular risk.</div>
</front>
</TEI>
<inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0012-186X</s0>
</fA01>
<fA03 i2="1"><s0>Diabetologia : (Berl.)</s0>
</fA03>
<fA05><s2>53</s2>
</fA05>
<fA06><s2>5</s2>
</fA06>
<fA08 i1="01" i2="1" l="ENG"><s1>The Framingham and UK Prospective Diabetes Study (UKPDS) risk equations do not reliably estimate the probability of cardiovascular events in a large ethnically diverse sample of patients with diabetes: the Action in Diabetes and Vascular Disease: Preterax and Diamicron-MR Controlled Evaluation (ADVANCE) Study</s1>
</fA08>
<fA11 i1="01" i2="1"><s1>KENGNE (A. P.)</s1>
</fA11>
<fA11 i1="02" i2="1"><s1>PATEL (A.)</s1>
</fA11>
<fA11 i1="03" i2="1"><s1>COLAGIURI (S.)</s1>
</fA11>
<fA11 i1="04" i2="1"><s1>HELLER (S.)</s1>
</fA11>
<fA11 i1="05" i2="1"><s1>HAMET (P.)</s1>
</fA11>
<fA11 i1="06" i2="1"><s1>MARRE (M.)</s1>
</fA11>
<fA11 i1="07" i2="1"><s1>PAN (C. Y.)</s1>
</fA11>
<fA11 i1="08" i2="1"><s1>ZOUNGAS (S.)</s1>
</fA11>
<fA11 i1="09" i2="1"><s1>GROBBEE (D. E.)</s1>
</fA11>
<fA11 i1="10" i2="1"><s1>NEAL (B.)</s1>
</fA11>
<fA11 i1="11" i2="1"><s1>CHALMERS (J.)</s1>
</fA11>
<fA11 i1="12" i2="1"><s1>WOODWARD (M.)</s1>
</fA11>
<fA14 i1="01"><s1>The George Institute for International Health, University of Sydney, PO Box M201, Level 10 KGV Building, RPAH, Missenden Road, Camperdown</s1>
<s2>Sydney, NSW 2050</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
</fA14>
<fA14 i1="02"><s1>Institute of Obesity, Nutrition and Exercise, Faculty of Medicine, The University of Sydney</s1>
<s2>Sydney, NSW</s2>
<s3>AUS</s3>
<sZ>3 aut.</sZ>
</fA14>
<fA14 i1="03"><s1>University of Sheffield and Sheffield Teaching Hospitals National Health Service (NHS) Foundation Trust</s1>
<s2>Sheffield</s2>
<s3>GBR</s3>
<sZ>4 aut.</sZ>
</fA14>
<fA14 i1="04"><s1>Centre Hospitalier de l'Université de Montréal, Université de Montréal</s1>
<s2>Montréal, QC</s2>
<s3>CAN</s3>
<sZ>5 aut.</sZ>
</fA14>
<fA14 i1="05"><s1>Hôpital Bichat-Claude Bernard and Université Paris 7</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>6 aut.</sZ>
</fA14>
<fA14 i1="06"><s1>Chinese People's Liberation Army General Hospital</s1>
<s2>Beijing</s2>
<s3>CHN</s3>
<sZ>7 aut.</sZ>
</fA14>
<fA14 i1="07"><s1>School of Public Health, Monash University</s1>
<s2>Melbourne, Victoria</s2>
<s3>AUS</s3>
<sZ>8 aut.</sZ>
</fA14>
<fA14 i1="08"><s1>Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht</s1>
<s2>Utrecht</s2>
<s3>NLD</s3>
<sZ>9 aut.</sZ>
</fA14>
<fA14 i1="09"><s1>Mount Sinai School of Medicine</s1>
<s2>New York, NY</s2>
<s3>USA</s3>
<sZ>12 aut.</sZ>
</fA14>
<fA17 i1="01" i2="1"><s1>ADVANCE Collaborative Group</s1>
<s3>INC</s3>
</fA17>
<fA20><s1>821-831</s1>
</fA20>
<fA21><s1>2010</s1>
</fA21>
<fA23 i1="01"><s0>ENG</s0>
</fA23>
<fA43 i1="01"><s1>INIST</s1>
<s2>13012</s2>
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<fA44><s0>0000</s0>
<s1>© 2010 INIST-CNRS. All rights reserved.</s1>
</fA44>
<fA45><s0>37 ref.</s0>
</fA45>
<fA47 i1="01" i2="1"><s0>10-0239448</s0>
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<fA60><s1>P</s1>
</fA60>
<fA61><s0>A</s0>
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<fA64 i1="01" i2="1"><s0>Diabetologia : (Berlin)</s0>
</fA64>
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</fA66>
<fC01 i1="01" l="ENG"><s0>Aims/hypothesis Available multivariable equations for cardiovascular risk assessment in people with diabetes have been derived either from the general population or from populations with diabetes. Their utility and comparative performance in a contemporary group of patients with type 2 diabetes are not well established. The aim of this study was to evaluate the performance of the Framingham and UK Prospective Diabetes Study (UKPDS) risk equations in participants who took part in the Action in Diabetes and Vascular disease: Preterax and Diamicron-MR Controlled Evaluation (ADVANCE) trial. Methods The 4-year risks of cardiovascular disease (CVD) and its constituents were estimated using two published Framingham and the UKPDS risk equations in 7,502 individuals with type 2 diabetes without prior known CVD at their enrolment in the trial. Results The risk of major CVD was overestimated by 170% (95% CI 146-195%) and 202% (176-231%) using the two Framingham equations. The risk of major coronary heart disease was overestimated by 198% (162-238%) with the UKPDS, and by 146% (117-179%) and 289% (243-341%) with the two different Framingham equations, respectively. The risks of stroke events were also overestimated with the UKPDS and one of the Framingham equations. The ability of these equations to rank risk among ADVANCE participants was modest, with c-statistics ranging from 0.57 to 0.71. Results stratified by sex, treatment allocation and ethnicity were broadly similar. Conclusions/interpretation Application of the Framingham and UKPDS risk equations to a contemporary treated group of patients with established type 2 diabetes is likely to substantially overestimate cardiovascular risk.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B21E01A</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Prospective</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Prospective</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Prospectiva</s0>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Facteur risque</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Risk factor</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Factor riesgo</s0>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Pathologie des vaisseaux sanguins</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Vascular disease</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Vaso sanguíneo patología</s0>
<s5>03</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Evaluation</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Evaluation</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Evaluación</s0>
<s5>04</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Pathologie de l'appareil circulatoire</s0>
<s5>07</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Cardiovascular disease</s0>
<s5>07</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Aparato circulatorio patología</s0>
<s5>07</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Discrimination</s0>
<s5>08</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Discrimination</s0>
<s5>08</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Discriminación</s0>
<s5>08</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Diabète</s0>
<s2>NM</s2>
<s5>09</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Diabetes mellitus</s0>
<s2>NM</s2>
<s5>09</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Diabetes</s0>
<s2>NM</s2>
<s5>09</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Prédiction</s0>
<s5>13</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Prediction</s0>
<s5>13</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>Predicción</s0>
<s5>13</s5>
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<fC03 i1="09" i2="X" l="FRE"><s0>Homme</s0>
<s5>72</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG"><s0>Human</s0>
<s5>72</s5>
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<fC03 i1="09" i2="X" l="SPA"><s0>Hombre</s0>
<s5>72</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Endocrinopathie</s0>
<s5>20</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Endocrinopathy</s0>
<s5>20</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Endocrinopatía</s0>
<s5>20</s5>
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<fN21><s1>158</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
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<server><NO>PASCAL 10-0239448 INIST</NO>
<ET>The Framingham and UK Prospective Diabetes Study (UKPDS) risk equations do not reliably estimate the probability of cardiovascular events in a large ethnically diverse sample of patients with diabetes: the Action in Diabetes and Vascular Disease: Preterax and Diamicron-MR Controlled Evaluation (ADVANCE) Study</ET>
<AU>KENGNE (A. P.); PATEL (A.); COLAGIURI (S.); HELLER (S.); HAMET (P.); MARRE (M.); PAN (C. Y.); ZOUNGAS (S.); GROBBEE (D. E.); NEAL (B.); CHALMERS (J.); WOODWARD (M.)</AU>
<AF>The George Institute for International Health, University of Sydney, PO Box M201, Level 10 KGV Building, RPAH, Missenden Road, Camperdown/Sydney, NSW 2050/Australie (1 aut., 2 aut., 8 aut., 10 aut., 11 aut., 12 aut.); Institute of Obesity, Nutrition and Exercise, Faculty of Medicine, The University of Sydney/Sydney, NSW/Australie (3 aut.); University of Sheffield and Sheffield Teaching Hospitals National Health Service (NHS) Foundation Trust/Sheffield/Royaume-Uni (4 aut.); Centre Hospitalier de l'Université de Montréal, Université de Montréal/Montréal, QC/Canada (5 aut.); Hôpital Bichat-Claude Bernard and Université Paris 7/Paris/France (6 aut.); Chinese People's Liberation Army General Hospital/Beijing/Chine (7 aut.); School of Public Health, Monash University/Melbourne, Victoria/Australie (8 aut.); Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht/Utrecht/Pays-Bas (9 aut.); Mount Sinai School of Medicine/New York, NY/Etats-Unis (12 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Diabetologia : (Berlin); ISSN 0012-186X; Allemagne; Da. 2010; Vol. 53; No. 5; Pp. 821-831; Bibl. 37 ref.</SO>
<LA>Anglais</LA>
<EA>Aims/hypothesis Available multivariable equations for cardiovascular risk assessment in people with diabetes have been derived either from the general population or from populations with diabetes. Their utility and comparative performance in a contemporary group of patients with type 2 diabetes are not well established. The aim of this study was to evaluate the performance of the Framingham and UK Prospective Diabetes Study (UKPDS) risk equations in participants who took part in the Action in Diabetes and Vascular disease: Preterax and Diamicron-MR Controlled Evaluation (ADVANCE) trial. Methods The 4-year risks of cardiovascular disease (CVD) and its constituents were estimated using two published Framingham and the UKPDS risk equations in 7,502 individuals with type 2 diabetes without prior known CVD at their enrolment in the trial. Results The risk of major CVD was overestimated by 170% (95% CI 146-195%) and 202% (176-231%) using the two Framingham equations. The risk of major coronary heart disease was overestimated by 198% (162-238%) with the UKPDS, and by 146% (117-179%) and 289% (243-341%) with the two different Framingham equations, respectively. The risks of stroke events were also overestimated with the UKPDS and one of the Framingham equations. The ability of these equations to rank risk among ADVANCE participants was modest, with c-statistics ranging from 0.57 to 0.71. Results stratified by sex, treatment allocation and ethnicity were broadly similar. Conclusions/interpretation Application of the Framingham and UKPDS risk equations to a contemporary treated group of patients with established type 2 diabetes is likely to substantially overestimate cardiovascular risk.</EA>
<CC>002B21E01A</CC>
<FD>Prospective; Facteur risque; Pathologie des vaisseaux sanguins; Evaluation; Pathologie de l'appareil circulatoire; Discrimination; Diabète; Prédiction; Homme</FD>
<FG>Endocrinopathie</FG>
<ED>Prospective; Risk factor; Vascular disease; Evaluation; Cardiovascular disease; Discrimination; Diabetes mellitus; Prediction; Human</ED>
<EG>Endocrinopathy</EG>
<SD>Prospectiva; Factor riesgo; Vaso sanguíneo patología; Evaluación; Aparato circulatorio patología; Discriminación; Diabetes; Predicción; Hombre</SD>
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<ID>10-0239448</ID>
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