Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight
Identifieur interne : 002427 ( PascalFrancis/Corpus ); précédent : 002426; suivant : 002428Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight
Auteurs : Rachel M. Freathy ; Dennis O. Mook-Kanamori ; Ulla Sovio ; Inga Prokopenko ; Nicholas J. Timpson ; Diane J. Berry ; Nicole M. Warrington ; Elisabeth Widen ; Jouke Jan Hottenga ; Marika Kaakinen ; Leslie A. Lange ; Jonathan P. Bradfield ; Marjan Kerkhof ; Julie A. Marsh ; Reedik M Gi ; Chih-Mei Chen ; Helen N. Lyon ; Mirna Kirin ; Linda S. Adair ; Yurii S. Aulchenko ; Amanda J. Bennett ; Judith B. Borja ; Nabila Bouatia-Naji ; Pimphen Charoen ; Lachlan J. M. Coin ; Diana L. Cousminer ; Eco J. C. De Geus ; Panos Deloukas ; Paul Elliott ; David M. Evans ; Philippe Froguel ; Beate Glaser ; Christopher J. Groves ; Anna-Liisa Hartikainen ; Neelam Hassanali ; Joel N. Hirschhorn ; Albert Hofman ; Jeff M. P. Holly ; Elina Hyppönen ; Stavroula Kanoni ; Bridget A. Knight ; Jaana Laitinen ; Cecilia M. Lindgren ; Wendy L. Mcardle ; Paul F. O'Reilly ; Craig E. Pennell ; Dirkje S. Postma ; Anneli Pouta ; Adaikalavan Ramasamy ; Nigel W. Rayner ; Susan M. Ring ; Fernando Rivadeneira ; Beverley M. Shields ; David P. Strachan ; Ida Surakka ; Anja Taanilal ; Carla TieslerSource :
- Nature genetics [ 1061-4036 ] ; 2010.
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Abstract
To identify genetic variants associated with birth weight, we meta-analyzed six genome-wide association (GWA) studies (n = 10,623 Europeans from pregnancy/birth cohorts) and followed up two lead signals in 13 replication studies (n = 27,591). rs900400 near LEER1 and CCNL1 (P = 2 x 10-35) and rs9883204 in ADCY5 (P = 7 x 10-15) were robustly associated with birth weight. Correlated SNPs in ADCY5 were recently implicated in regulation of glucose levels and susceptibility to type 2 diabetes1, providing evidence that the well-described association between lower birth weight and subsequent type 2 diabetes2,3 has a genetic component, distinct from the proposed role of programming by maternal nutrition. Using data from both SNPs, we found that the 9% of Europeans carrying four birth weight-lowering alleles were, on average, 113 g (95% CI 89-137 g) lighter at birth than the 24% with zero or one alleles (Ptrend = 7 x 10-30). The impact on birth weight is similar to that of a mother smoking 4-5 cigarettes per day in the third trimester of pregnancy4.
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| NO : | PASCAL 10-0400434 INIST |
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| ET : | Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight |
| AU : | FREATHY (Rachel M.); MOOK-KANAMORI (Dennis O.); SOVIO (Ulla); PROKOPENKO (Inga); TIMPSON (Nicholas J.); BERRY (Diane J.); WARRINGTON (Nicole M.); WIDEN (Elisabeth); HOTTENGA (Jouke Jan); KAAKINEN (Marika); LANGE (Leslie A.); BRADFIELD (Jonathan P.); KERKHOF (Marjan); MARSH (Julie A.); MÄGI (Reedik); CHEN (Chih-Mei); LYON (Helen N.); KIRIN (Mirna); ADAIR (Linda S.); AULCHENKO (Yurii S.); BENNETT (Amanda J.); BORJA (Judith B.); BOUATIA-NAJI (Nabila); CHAROEN (Pimphen); COIN (Lachlan J. M.); COUSMINER (Diana L.); DE GEUS (Eco J. C.); DELOUKAS (Panos); ELLIOTT (Paul); EVANS (David M.); FROGUEL (Philippe); GLASER (Beate); GROVES (Christopher J.); HARTIKAINEN (Anna-Liisa); HASSANALI (Neelam); HIRSCHHORN (Joel N.); HOFMAN (Albert); HOLLY (Jeff M. P.); HYPPÖNEN (Elina); KANONI (Stavroula); KNIGHT (Bridget A.); LAITINEN (Jaana); LINDGREN (Cecilia M.); MCARDLE (Wendy L.); O'REILLY (Paul F.); PENNELL (Craig E.); POSTMA (Dirkje S.); POUTA (Anneli); RAMASAMY (Adaikalavan); RAYNER (Nigel W.); RING (Susan M.); RIVADENEIRA (Fernando); SHIELDS (Beverley M.); STRACHAN (David P.); SURAKKA (Ida); TAANILAL (Anja); TIESLER (Carla) |
| AF : | Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter/Exeter/Royaume-Uni (1 aut., 4 aut.); Department of Pediatrics, Erasmus Medical Center/Rotterdam/Pays-Bas (2 aut.); Department of Epidemiology, Erasmus Medical Center/Rotterdam/Pays-Bas (2 aut., 20 aut., 37 aut., 52 aut., 56 aut.); The Generation R Study, Erasmus Medical Center/Rotterdam/Pays-Bas (2 aut.); Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London/London/Royaume-Uni (3 aut., 24 aut., 25 aut., 29 aut., 45 aut., 49 aut.); Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford/Royaume-Uni (4 aut., 15 aut., 21 aut., 33 aut., 35 aut., 43 aut., 50 aut.); Wellcome Trust Centre for Human Genetics, University of Oxford/Oxford/Royaume-Uni (15 aut., 43 aut., 50 aut.); The Medical Research Council (MRC) Centre for Causal Analyses in Translational Epidemiology, Department of Social Medicine, University of Bristol, Oakfield House/Bristol/Royaume-Uni (5 aut., 30 aut., 32 aut.); Centre for Paediatric Epidemiology and Biostatistics, MRC Centre of Epidemiology for Child Health, University College of London Institute of Child Health/London/Royaume-Uni (6 aut., 39 aut.); Centre for Genetic Epidemiology and Biostatistics, The University of Western Australia/Perth, Western Australia/Australie (7 aut., 14 aut.); Institute for Molecular Medicine Finland (FIMM), University of Helsinki/Helsinki/Finlande (8 aut., 26 aut., 55 aut.); Department of Biological Psychology, Vrije Universiteit Amsterdam/Amsterdam/Pays-Bas (9 aut., 27 aut.); Institute of Health Sciences, University of Oulu/Oulu/Finlande (10 aut.); Biocenter Oulu, University of Oulu/Oulu/Finlande (10 aut.); Department of Genetics, University of North Carolina/Chapel Hill, North Carolina/Etats-Unis (11 aut.); Center for Applied Genomics, The Children's Hospital of Philadelphia/Pennsylvania/Etats-Unis (12 aut.); Department of Epidemiology, University Medical Center Groningen, University of Groningen/Groningen/Pays-Bas (13 aut.); Helmholtz Zentrum Muenchen, German Research Centre for Environmental Health, Institute of Epidemiology/Neuherberg/Allemagne (16 aut., 57 aut.); Ludwig-Maximilians University of Munich, Dr. von Hauner Children's Hospital/Munich/Allemagne (16 aut., 57 aut.); Division of Genetics, Program in Genomics, Children's Hospital/Boston, Massachusetts/Etats-Unis (17 aut., 36 aut.); Department of Pediatrics, Harvard Medical School/Boston, Massachusetts/Etats-Unis (17 aut.); Centre for Population Health Sciences, University of Edinburgh/Edinburgh, Scotland/Royaume-Uni (18 aut.); Department of Nutrition, University of North Carolina/Chapel Hill, North Carolina/Etats-Unis (19 aut.); Office of Population Studies Foundation, University of San Carlos/Cebu City/Philippines (22 aut.); Centre National de la Recherche Scientifique, UMR 8199, Institute of Biology, Pasteur Institute of Lille/Lille/France (23 aut., 31 aut.) |
| DT : | Publication en série; Correspondance, lettre; Niveau analytique |
| SO : | Nature genetics; ISSN 1061-4036; Coden NGENEC; Etats-Unis; Da. 2010; Vol. 42; No. 5; Pp. 430-435; Bibl. 32 ref. |
| LA : | Anglais |
| EA : | To identify genetic variants associated with birth weight, we meta-analyzed six genome-wide association (GWA) studies (n = 10,623 Europeans from pregnancy/birth cohorts) and followed up two lead signals in 13 replication studies (n = 27,591). rs900400 near LEER1 and CCNL1 (P = 2 x 10-35) and rs9883204 in ADCY5 (P = 7 x 10-15) were robustly associated with birth weight. Correlated SNPs in ADCY5 were recently implicated in regulation of glucose levels and susceptibility to type 2 diabetes1, providing evidence that the well-described association between lower birth weight and subsequent type 2 diabetes2,3 has a genetic component, distinct from the proposed role of programming by maternal nutrition. Using data from both SNPs, we found that the 9% of Europeans carrying four birth weight-lowering alleles were, on average, 113 g (95% CI 89-137 g) lighter at birth than the 24% with zero or one alleles (Ptrend = 7 x 10-30). The impact on birth weight is similar to that of a mother smoking 4-5 cigarettes per day in the third trimester of pregnancy4. |
| CC : | 002A07 |
| FD : | Variant; Foetus; Croissance; Poids naissance |
| ED : | Variant; Fetus; Growth; Birth weight |
| SD : | Variante; Feto; Crecimiento; Peso nacimiento |
| LO : | INIST-22883.354000193914090110 |
| ID : | 10-0400434 |
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Pascal:10-0400434Le document en format XML
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Lange</name><affiliation><inist:fA14 i1="15"><s1>Department of Genetics, University of North Carolina</s1><s2>Chapel Hill, North Carolina</s2><s3>USA</s3><sZ>11 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Bradfield, Jonathan P" sort="Bradfield, Jonathan P" uniqKey="Bradfield J" first="Jonathan P." last="Bradfield">Jonathan P. 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Marsh</name><affiliation><inist:fA14 i1="10"><s1>Centre for Genetic Epidemiology and Biostatistics, The University of Western Australia</s1><s2>Perth, Western Australia</s2><s3>AUS</s3><sZ>7 aut.</sZ><sZ>14 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="M Gi, Reedik" sort="M Gi, Reedik" uniqKey="M Gi R" first="Reedik" last="M Gi">Reedik M Gi</name><affiliation><inist:fA14 i1="06"><s1>Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford</s1><s3>GBR</s3><sZ>4 aut.</sZ><sZ>15 aut.</sZ><sZ>21 aut.</sZ><sZ>33 aut.</sZ><sZ>35 aut.</sZ><sZ>43 aut.</sZ><sZ>50 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="07"><s1>Wellcome Trust Centre for Human Genetics, University of Oxford</s1><s2>Oxford</s2><s3>GBR</s3><sZ>15 aut.</sZ><sZ>43 aut.</sZ><sZ>50 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Chen, Chih Mei" sort="Chen, Chih Mei" uniqKey="Chen C" first="Chih-Mei" last="Chen">Chih-Mei Chen</name><affiliation><inist:fA14 i1="18"><s1>Helmholtz Zentrum Muenchen, German Research Centre for Environmental Health, Institute of Epidemiology</s1><s2>Neuherberg</s2><s3>DEU</s3><sZ>16 aut.</sZ><sZ>57 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="19"><s1>Ludwig-Maximilians University of Munich, Dr. von Hauner Children's Hospital</s1><s2>Munich</s2><s3>DEU</s3><sZ>16 aut.</sZ><sZ>57 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Lyon, Helen N" sort="Lyon, Helen N" uniqKey="Lyon H" first="Helen N." last="Lyon">Helen N. Lyon</name><affiliation><inist:fA14 i1="20"><s1>Division of Genetics, Program in Genomics, Children's Hospital</s1><s2>Boston, Massachusetts</s2><s3>USA</s3><sZ>17 aut.</sZ><sZ>36 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="21"><s1>Department of Pediatrics, Harvard Medical School</s1><s2>Boston, Massachusetts</s2><s3>USA</s3><sZ>17 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Kirin, Mirna" sort="Kirin, Mirna" uniqKey="Kirin M" first="Mirna" last="Kirin">Mirna Kirin</name><affiliation><inist:fA14 i1="22"><s1>Centre for Population Health Sciences, University of Edinburgh</s1><s2>Edinburgh, Scotland</s2><s3>GBR</s3><sZ>18 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Adair, Linda S" sort="Adair, Linda S" uniqKey="Adair L" first="Linda S." last="Adair">Linda S. Adair</name><affiliation><inist:fA14 i1="23"><s1>Department of Nutrition, University of North Carolina</s1><s2>Chapel Hill, North Carolina</s2><s3>USA</s3><sZ>19 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Aulchenko, Yurii S" sort="Aulchenko, Yurii S" uniqKey="Aulchenko Y" first="Yurii S." last="Aulchenko">Yurii S. Aulchenko</name><affiliation><inist:fA14 i1="03"><s1>Department of Epidemiology, Erasmus Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>2 aut.</sZ><sZ>20 aut.</sZ><sZ>37 aut.</sZ><sZ>52 aut.</sZ><sZ>56 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Bennett, Amanda J" sort="Bennett, Amanda J" uniqKey="Bennett A" first="Amanda J." last="Bennett">Amanda J. Bennett</name><affiliation><inist:fA14 i1="06"><s1>Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford</s1><s3>GBR</s3><sZ>4 aut.</sZ><sZ>15 aut.</sZ><sZ>21 aut.</sZ><sZ>33 aut.</sZ><sZ>35 aut.</sZ><sZ>43 aut.</sZ><sZ>50 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Borja, Judith B" sort="Borja, Judith B" uniqKey="Borja J" first="Judith B." last="Borja">Judith B. Borja</name><affiliation><inist:fA14 i1="24"><s1>Office of Population Studies Foundation, University of San Carlos</s1><s2>Cebu City</s2><s3>PHL</s3><sZ>22 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Bouatia Naji, Nabila" sort="Bouatia Naji, Nabila" uniqKey="Bouatia Naji N" first="Nabila" last="Bouatia-Naji">Nabila Bouatia-Naji</name><affiliation><inist:fA14 i1="25"><s1>Centre<sub> </sub>National de la Recherche Scientifique, UMR 8199, Institute of Biology, Pasteur Institute of Lille</s1><s2>Lille</s2><s3>FRA</s3><sZ>23 aut.</sZ><sZ>31 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Charoen, Pimphen" sort="Charoen, Pimphen" uniqKey="Charoen P" first="Pimphen" last="Charoen">Pimphen Charoen</name><affiliation><inist:fA14 i1="05"><s1>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London</s1><s2>London</s2><s3>GBR</s3><sZ>3 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>29 aut.</sZ><sZ>45 aut.</sZ><sZ>49 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Coin, Lachlan J M" sort="Coin, Lachlan J M" uniqKey="Coin L" first="Lachlan J. M." last="Coin">Lachlan J. M. Coin</name><affiliation><inist:fA14 i1="05"><s1>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London</s1><s2>London</s2><s3>GBR</s3><sZ>3 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>29 aut.</sZ><sZ>45 aut.</sZ><sZ>49 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Cousminer, Diana L" sort="Cousminer, Diana L" uniqKey="Cousminer D" first="Diana L." last="Cousminer">Diana L. Cousminer</name><affiliation><inist:fA14 i1="11"><s1>Institute for Molecular Medicine Finland (FIMM), University of Helsinki</s1><s2>Helsinki</s2><s3>FIN</s3><sZ>8 aut.</sZ><sZ>26 aut.</sZ><sZ>55 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="De Geus, Eco J C" sort="De Geus, Eco J C" uniqKey="De Geus E" first="Eco J. C." last="De Geus">Eco J. C. De Geus</name><affiliation><inist:fA14 i1="12"><s1>Department of Biological Psychology, Vrije Universiteit Amsterdam</s1><s2>Amsterdam</s2><s3>NLD</s3><sZ>9 aut.</sZ><sZ>27 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Deloukas, Panos" sort="Deloukas, Panos" uniqKey="Deloukas P" first="Panos" last="Deloukas">Panos Deloukas</name></author><author><name sortKey="Elliott, Paul" sort="Elliott, Paul" uniqKey="Elliott P" first="Paul" last="Elliott">Paul Elliott</name><affiliation><inist:fA14 i1="05"><s1>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London</s1><s2>London</s2><s3>GBR</s3><sZ>3 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>29 aut.</sZ><sZ>45 aut.</sZ><sZ>49 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Evans, David M" sort="Evans, David M" uniqKey="Evans D" first="David M." last="Evans">David M. Evans</name><affiliation><inist:fA14 i1="08"><s1>The Medical Research Council (MRC) Centre for Causal Analyses in Translational Epidemiology, Department of Social Medicine, University of Bristol, Oakfield House</s1><s2>Bristol</s2><s3>GBR</s3><sZ>5 aut.</sZ><sZ>30 aut.</sZ><sZ>32 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Froguel, Philippe" sort="Froguel, Philippe" uniqKey="Froguel P" first="Philippe" last="Froguel">Philippe Froguel</name><affiliation><inist:fA14 i1="25"><s1>Centre<sub> </sub>National de la Recherche Scientifique, UMR 8199, Institute of Biology, Pasteur Institute of Lille</s1><s2>Lille</s2><s3>FRA</s3><sZ>23 aut.</sZ><sZ>31 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Glaser, Beate" sort="Glaser, Beate" uniqKey="Glaser B" first="Beate" last="Glaser">Beate Glaser</name><affiliation><inist:fA14 i1="08"><s1>The Medical Research Council (MRC) Centre for Causal Analyses in Translational Epidemiology, Department of Social Medicine, University of Bristol, Oakfield House</s1><s2>Bristol</s2><s3>GBR</s3><sZ>5 aut.</sZ><sZ>30 aut.</sZ><sZ>32 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Groves, Christopher J" sort="Groves, Christopher J" uniqKey="Groves C" first="Christopher J." last="Groves">Christopher J. Groves</name><affiliation><inist:fA14 i1="06"><s1>Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford</s1><s3>GBR</s3><sZ>4 aut.</sZ><sZ>15 aut.</sZ><sZ>21 aut.</sZ><sZ>33 aut.</sZ><sZ>35 aut.</sZ><sZ>43 aut.</sZ><sZ>50 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Hartikainen, Anna Liisa" sort="Hartikainen, Anna Liisa" uniqKey="Hartikainen A" first="Anna-Liisa" last="Hartikainen">Anna-Liisa Hartikainen</name></author><author><name sortKey="Hassanali, Neelam" sort="Hassanali, Neelam" uniqKey="Hassanali N" first="Neelam" last="Hassanali">Neelam Hassanali</name><affiliation><inist:fA14 i1="06"><s1>Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford</s1><s3>GBR</s3><sZ>4 aut.</sZ><sZ>15 aut.</sZ><sZ>21 aut.</sZ><sZ>33 aut.</sZ><sZ>35 aut.</sZ><sZ>43 aut.</sZ><sZ>50 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Hirschhorn, Joel N" sort="Hirschhorn, Joel N" uniqKey="Hirschhorn J" first="Joel N." last="Hirschhorn">Joel N. Hirschhorn</name><affiliation><inist:fA14 i1="20"><s1>Division of Genetics, Program in Genomics, Children's Hospital</s1><s2>Boston, Massachusetts</s2><s3>USA</s3><sZ>17 aut.</sZ><sZ>36 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation><inist:fA14 i1="03"><s1>Department of Epidemiology, Erasmus Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>2 aut.</sZ><sZ>20 aut.</sZ><sZ>37 aut.</sZ><sZ>52 aut.</sZ><sZ>56 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Holly, Jeff M P" sort="Holly, Jeff M P" uniqKey="Holly J" first="Jeff M. P." last="Holly">Jeff M. P. Holly</name></author><author><name sortKey="Hypponen, Elina" sort="Hypponen, Elina" uniqKey="Hypponen E" first="Elina" last="Hyppönen">Elina Hyppönen</name><affiliation><inist:fA14 i1="09"><s1>Centre for Paediatric Epidemiology and Biostatistics, MRC Centre of Epidemiology for Child Health, University College of London Institute of Child Health</s1><s2>London</s2><s3>GBR</s3><sZ>6 aut.</sZ><sZ>39 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Kanoni, Stavroula" sort="Kanoni, Stavroula" uniqKey="Kanoni S" first="Stavroula" last="Kanoni">Stavroula Kanoni</name></author><author><name sortKey="Knight, Bridget A" sort="Knight, Bridget A" uniqKey="Knight B" first="Bridget A." last="Knight">Bridget A. Knight</name></author><author><name sortKey="Laitinen, Jaana" sort="Laitinen, Jaana" uniqKey="Laitinen J" first="Jaana" last="Laitinen">Jaana Laitinen</name></author><author><name sortKey="Lindgren, Cecilia M" sort="Lindgren, Cecilia M" uniqKey="Lindgren C" first="Cecilia M." last="Lindgren">Cecilia M. Lindgren</name><affiliation><inist:fA14 i1="06"><s1>Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford</s1><s3>GBR</s3><sZ>4 aut.</sZ><sZ>15 aut.</sZ><sZ>21 aut.</sZ><sZ>33 aut.</sZ><sZ>35 aut.</sZ><sZ>43 aut.</sZ><sZ>50 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="07"><s1>Wellcome Trust Centre for Human Genetics, University of Oxford</s1><s2>Oxford</s2><s3>GBR</s3><sZ>15 aut.</sZ><sZ>43 aut.</sZ><sZ>50 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Mcardle, Wendy L" sort="Mcardle, Wendy L" uniqKey="Mcardle W" first="Wendy L." last="Mcardle">Wendy L. Mcardle</name></author><author><name sortKey="O Reilly, Paul F" sort="O Reilly, Paul F" uniqKey="O Reilly P" first="Paul F." last="O'Reilly">Paul F. O'Reilly</name><affiliation><inist:fA14 i1="05"><s1>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London</s1><s2>London</s2><s3>GBR</s3><sZ>3 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>29 aut.</sZ><sZ>45 aut.</sZ><sZ>49 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Pennell, Craig E" sort="Pennell, Craig E" uniqKey="Pennell C" first="Craig E." last="Pennell">Craig E. Pennell</name></author><author><name sortKey="Postma, Dirkje S" sort="Postma, Dirkje S" uniqKey="Postma D" first="Dirkje S." last="Postma">Dirkje S. Postma</name></author><author><name sortKey="Pouta, Anneli" sort="Pouta, Anneli" uniqKey="Pouta A" first="Anneli" last="Pouta">Anneli Pouta</name></author><author><name sortKey="Ramasamy, Adaikalavan" sort="Ramasamy, Adaikalavan" uniqKey="Ramasamy A" first="Adaikalavan" last="Ramasamy">Adaikalavan Ramasamy</name><affiliation><inist:fA14 i1="05"><s1>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London</s1><s2>London</s2><s3>GBR</s3><sZ>3 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>29 aut.</sZ><sZ>45 aut.</sZ><sZ>49 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Rayner, Nigel W" sort="Rayner, Nigel W" uniqKey="Rayner N" first="Nigel W." last="Rayner">Nigel W. Rayner</name><affiliation><inist:fA14 i1="06"><s1>Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford</s1><s3>GBR</s3><sZ>4 aut.</sZ><sZ>15 aut.</sZ><sZ>21 aut.</sZ><sZ>33 aut.</sZ><sZ>35 aut.</sZ><sZ>43 aut.</sZ><sZ>50 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="07"><s1>Wellcome Trust Centre for Human Genetics, University of Oxford</s1><s2>Oxford</s2><s3>GBR</s3><sZ>15 aut.</sZ><sZ>43 aut.</sZ><sZ>50 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Ring, Susan M" sort="Ring, Susan M" uniqKey="Ring S" first="Susan M." last="Ring">Susan M. Ring</name></author><author><name sortKey="Rivadeneira, Fernando" sort="Rivadeneira, Fernando" uniqKey="Rivadeneira F" first="Fernando" last="Rivadeneira">Fernando Rivadeneira</name><affiliation><inist:fA14 i1="03"><s1>Department of Epidemiology, Erasmus Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>2 aut.</sZ><sZ>20 aut.</sZ><sZ>37 aut.</sZ><sZ>52 aut.</sZ><sZ>56 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Shields, Beverley M" sort="Shields, Beverley M" uniqKey="Shields B" first="Beverley M." last="Shields">Beverley M. Shields</name></author><author><name sortKey="Strachan, David P" sort="Strachan, David P" uniqKey="Strachan D" first="David P." last="Strachan">David P. Strachan</name></author><author><name sortKey="Surakka, Ida" sort="Surakka, Ida" uniqKey="Surakka I" first="Ida" last="Surakka">Ida Surakka</name><affiliation><inist:fA14 i1="11"><s1>Institute for Molecular Medicine Finland (FIMM), University of Helsinki</s1><s2>Helsinki</s2><s3>FIN</s3><sZ>8 aut.</sZ><sZ>26 aut.</sZ><sZ>55 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Taanilal, Anja" sort="Taanilal, Anja" uniqKey="Taanilal A" first="Anja" last="Taanilal">Anja Taanilal</name><affiliation><inist:fA14 i1="03"><s1>Department of Epidemiology, Erasmus Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>2 aut.</sZ><sZ>20 aut.</sZ><sZ>37 aut.</sZ><sZ>52 aut.</sZ><sZ>56 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Tiesler, Carla" sort="Tiesler, Carla" uniqKey="Tiesler C" first="Carla" last="Tiesler">Carla Tiesler</name><affiliation><inist:fA14 i1="18"><s1>Helmholtz Zentrum Muenchen, German Research Centre for Environmental Health, Institute of Epidemiology</s1><s2>Neuherberg</s2><s3>DEU</s3><sZ>16 aut.</sZ><sZ>57 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="19"><s1>Ludwig-Maximilians University of Munich, Dr. von Hauner Children's Hospital</s1><s2>Munich</s2><s3>DEU</s3><sZ>16 aut.</sZ><sZ>57 aut.</sZ></inist:fA14></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">10-0400434</idno><date when="2010">2010</date><idno type="stanalyst">PASCAL 10-0400434 INIST</idno><idno type="RBID">Pascal:10-0400434</idno><idno type="wicri:Area/PascalFrancis/Corpus">002427</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight</title><author><name sortKey="Freathy, Rachel M" sort="Freathy, Rachel M" uniqKey="Freathy R" first="Rachel M." last="Freathy">Rachel M. Freathy</name><affiliation><inist:fA14 i1="01"><s1>Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter</s1><s2>Exeter</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Mook Kanamori, Dennis O" sort="Mook Kanamori, Dennis O" uniqKey="Mook Kanamori D" first="Dennis O." last="Mook-Kanamori">Dennis O. Mook-Kanamori</name><affiliation><inist:fA14 i1="02"><s1>Department of Pediatrics, Erasmus Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>2 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="03"><s1>Department of Epidemiology, Erasmus Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>2 aut.</sZ><sZ>20 aut.</sZ><sZ>37 aut.</sZ><sZ>52 aut.</sZ><sZ>56 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="04"><s1>The Generation R Study, Erasmus Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>2 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Sovio, Ulla" sort="Sovio, Ulla" uniqKey="Sovio U" first="Ulla" last="Sovio">Ulla Sovio</name><affiliation><inist:fA14 i1="05"><s1>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London</s1><s2>London</s2><s3>GBR</s3><sZ>3 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>29 aut.</sZ><sZ>45 aut.</sZ><sZ>49 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Prokopenko, Inga" sort="Prokopenko, Inga" uniqKey="Prokopenko I" first="Inga" last="Prokopenko">Inga Prokopenko</name><affiliation><inist:fA14 i1="01"><s1>Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter</s1><s2>Exeter</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="06"><s1>Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford</s1><s3>GBR</s3><sZ>4 aut.</sZ><sZ>15 aut.</sZ><sZ>21 aut.</sZ><sZ>33 aut.</sZ><sZ>35 aut.</sZ><sZ>43 aut.</sZ><sZ>50 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Timpson, Nicholas J" sort="Timpson, Nicholas J" uniqKey="Timpson N" first="Nicholas J." last="Timpson">Nicholas J. Timpson</name><affiliation><inist:fA14 i1="08"><s1>The Medical Research Council (MRC) Centre for Causal Analyses in Translational Epidemiology, Department of Social Medicine, University of Bristol, Oakfield House</s1><s2>Bristol</s2><s3>GBR</s3><sZ>5 aut.</sZ><sZ>30 aut.</sZ><sZ>32 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Berry, Diane J" sort="Berry, Diane J" uniqKey="Berry D" first="Diane J." last="Berry">Diane J. Berry</name><affiliation><inist:fA14 i1="09"><s1>Centre for Paediatric Epidemiology and Biostatistics, MRC Centre of Epidemiology for Child Health, University College of London Institute of Child Health</s1><s2>London</s2><s3>GBR</s3><sZ>6 aut.</sZ><sZ>39 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Warrington, Nicole M" sort="Warrington, Nicole M" uniqKey="Warrington N" first="Nicole M." last="Warrington">Nicole M. Warrington</name><affiliation><inist:fA14 i1="10"><s1>Centre for Genetic Epidemiology and Biostatistics, The University of Western Australia</s1><s2>Perth, Western Australia</s2><s3>AUS</s3><sZ>7 aut.</sZ><sZ>14 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Widen, Elisabeth" sort="Widen, Elisabeth" uniqKey="Widen E" first="Elisabeth" last="Widen">Elisabeth Widen</name><affiliation><inist:fA14 i1="11"><s1>Institute for Molecular Medicine Finland (FIMM), University of Helsinki</s1><s2>Helsinki</s2><s3>FIN</s3><sZ>8 aut.</sZ><sZ>26 aut.</sZ><sZ>55 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Hottenga, Jouke Jan" sort="Hottenga, Jouke Jan" uniqKey="Hottenga J" first="Jouke Jan" last="Hottenga">Jouke Jan Hottenga</name><affiliation><inist:fA14 i1="12"><s1>Department of Biological Psychology, Vrije Universiteit Amsterdam</s1><s2>Amsterdam</s2><s3>NLD</s3><sZ>9 aut.</sZ><sZ>27 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Kaakinen, Marika" sort="Kaakinen, Marika" uniqKey="Kaakinen M" first="Marika" last="Kaakinen">Marika Kaakinen</name><affiliation><inist:fA14 i1="13"><s1>Institute of Health Sciences, University of Oulu</s1><s2>Oulu</s2><s3>FIN</s3><sZ>10 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="14"><s1>Biocenter Oulu, University of Oulu</s1><s2>Oulu</s2><s3>FIN</s3><sZ>10 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Lange, Leslie A" sort="Lange, Leslie A" uniqKey="Lange L" first="Leslie A." last="Lange">Leslie A. Lange</name><affiliation><inist:fA14 i1="15"><s1>Department of Genetics, University of North Carolina</s1><s2>Chapel Hill, North Carolina</s2><s3>USA</s3><sZ>11 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Bradfield, Jonathan P" sort="Bradfield, Jonathan P" uniqKey="Bradfield J" first="Jonathan P." last="Bradfield">Jonathan P. Bradfield</name><affiliation><inist:fA14 i1="16"><s1>Center for Applied Genomics, The Children's Hospital of Philadelphia</s1><s2>Pennsylvania</s2><s3>USA</s3><sZ>12 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Kerkhof, Marjan" sort="Kerkhof, Marjan" uniqKey="Kerkhof M" first="Marjan" last="Kerkhof">Marjan Kerkhof</name><affiliation><inist:fA14 i1="17"><s1>Department of Epidemiology, University Medical Center Groningen, University of Groningen</s1><s2>Groningen</s2><s3>NLD</s3><sZ>13 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Marsh, Julie A" sort="Marsh, Julie A" uniqKey="Marsh J" first="Julie A." last="Marsh">Julie A. Marsh</name><affiliation><inist:fA14 i1="10"><s1>Centre for Genetic Epidemiology and Biostatistics, The University of Western Australia</s1><s2>Perth, Western Australia</s2><s3>AUS</s3><sZ>7 aut.</sZ><sZ>14 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="M Gi, Reedik" sort="M Gi, Reedik" uniqKey="M Gi R" first="Reedik" last="M Gi">Reedik M Gi</name><affiliation><inist:fA14 i1="06"><s1>Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford</s1><s3>GBR</s3><sZ>4 aut.</sZ><sZ>15 aut.</sZ><sZ>21 aut.</sZ><sZ>33 aut.</sZ><sZ>35 aut.</sZ><sZ>43 aut.</sZ><sZ>50 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="07"><s1>Wellcome Trust Centre for Human Genetics, University of Oxford</s1><s2>Oxford</s2><s3>GBR</s3><sZ>15 aut.</sZ><sZ>43 aut.</sZ><sZ>50 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Chen, Chih Mei" sort="Chen, Chih Mei" uniqKey="Chen C" first="Chih-Mei" last="Chen">Chih-Mei Chen</name><affiliation><inist:fA14 i1="18"><s1>Helmholtz Zentrum Muenchen, German Research Centre for Environmental Health, Institute of Epidemiology</s1><s2>Neuherberg</s2><s3>DEU</s3><sZ>16 aut.</sZ><sZ>57 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="19"><s1>Ludwig-Maximilians University of Munich, Dr. von Hauner Children's Hospital</s1><s2>Munich</s2><s3>DEU</s3><sZ>16 aut.</sZ><sZ>57 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Lyon, Helen N" sort="Lyon, Helen N" uniqKey="Lyon H" first="Helen N." last="Lyon">Helen N. Lyon</name><affiliation><inist:fA14 i1="20"><s1>Division of Genetics, Program in Genomics, Children's Hospital</s1><s2>Boston, Massachusetts</s2><s3>USA</s3><sZ>17 aut.</sZ><sZ>36 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="21"><s1>Department of Pediatrics, Harvard Medical School</s1><s2>Boston, Massachusetts</s2><s3>USA</s3><sZ>17 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Kirin, Mirna" sort="Kirin, Mirna" uniqKey="Kirin M" first="Mirna" last="Kirin">Mirna Kirin</name><affiliation><inist:fA14 i1="22"><s1>Centre for Population Health Sciences, University of Edinburgh</s1><s2>Edinburgh, Scotland</s2><s3>GBR</s3><sZ>18 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Adair, Linda S" sort="Adair, Linda S" uniqKey="Adair L" first="Linda S." last="Adair">Linda S. Adair</name><affiliation><inist:fA14 i1="23"><s1>Department of Nutrition, University of North Carolina</s1><s2>Chapel Hill, North Carolina</s2><s3>USA</s3><sZ>19 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Aulchenko, Yurii S" sort="Aulchenko, Yurii S" uniqKey="Aulchenko Y" first="Yurii S." last="Aulchenko">Yurii S. Aulchenko</name><affiliation><inist:fA14 i1="03"><s1>Department of Epidemiology, Erasmus Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>2 aut.</sZ><sZ>20 aut.</sZ><sZ>37 aut.</sZ><sZ>52 aut.</sZ><sZ>56 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Bennett, Amanda J" sort="Bennett, Amanda J" uniqKey="Bennett A" first="Amanda J." last="Bennett">Amanda J. Bennett</name><affiliation><inist:fA14 i1="06"><s1>Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford</s1><s3>GBR</s3><sZ>4 aut.</sZ><sZ>15 aut.</sZ><sZ>21 aut.</sZ><sZ>33 aut.</sZ><sZ>35 aut.</sZ><sZ>43 aut.</sZ><sZ>50 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Borja, Judith B" sort="Borja, Judith B" uniqKey="Borja J" first="Judith B." last="Borja">Judith B. Borja</name><affiliation><inist:fA14 i1="24"><s1>Office of Population Studies Foundation, University of San Carlos</s1><s2>Cebu City</s2><s3>PHL</s3><sZ>22 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Bouatia Naji, Nabila" sort="Bouatia Naji, Nabila" uniqKey="Bouatia Naji N" first="Nabila" last="Bouatia-Naji">Nabila Bouatia-Naji</name><affiliation><inist:fA14 i1="25"><s1>Centre<sub> </sub>National de la Recherche Scientifique, UMR 8199, Institute of Biology, Pasteur Institute of Lille</s1><s2>Lille</s2><s3>FRA</s3><sZ>23 aut.</sZ><sZ>31 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Charoen, Pimphen" sort="Charoen, Pimphen" uniqKey="Charoen P" first="Pimphen" last="Charoen">Pimphen Charoen</name><affiliation><inist:fA14 i1="05"><s1>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London</s1><s2>London</s2><s3>GBR</s3><sZ>3 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>29 aut.</sZ><sZ>45 aut.</sZ><sZ>49 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Coin, Lachlan J M" sort="Coin, Lachlan J M" uniqKey="Coin L" first="Lachlan J. M." last="Coin">Lachlan J. M. Coin</name><affiliation><inist:fA14 i1="05"><s1>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London</s1><s2>London</s2><s3>GBR</s3><sZ>3 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>29 aut.</sZ><sZ>45 aut.</sZ><sZ>49 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Cousminer, Diana L" sort="Cousminer, Diana L" uniqKey="Cousminer D" first="Diana L." last="Cousminer">Diana L. Cousminer</name><affiliation><inist:fA14 i1="11"><s1>Institute for Molecular Medicine Finland (FIMM), University of Helsinki</s1><s2>Helsinki</s2><s3>FIN</s3><sZ>8 aut.</sZ><sZ>26 aut.</sZ><sZ>55 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="De Geus, Eco J C" sort="De Geus, Eco J C" uniqKey="De Geus E" first="Eco J. C." last="De Geus">Eco J. C. De Geus</name><affiliation><inist:fA14 i1="12"><s1>Department of Biological Psychology, Vrije Universiteit Amsterdam</s1><s2>Amsterdam</s2><s3>NLD</s3><sZ>9 aut.</sZ><sZ>27 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Deloukas, Panos" sort="Deloukas, Panos" uniqKey="Deloukas P" first="Panos" last="Deloukas">Panos Deloukas</name></author><author><name sortKey="Elliott, Paul" sort="Elliott, Paul" uniqKey="Elliott P" first="Paul" last="Elliott">Paul Elliott</name><affiliation><inist:fA14 i1="05"><s1>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London</s1><s2>London</s2><s3>GBR</s3><sZ>3 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>29 aut.</sZ><sZ>45 aut.</sZ><sZ>49 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Evans, David M" sort="Evans, David M" uniqKey="Evans D" first="David M." last="Evans">David M. Evans</name><affiliation><inist:fA14 i1="08"><s1>The Medical Research Council (MRC) Centre for Causal Analyses in Translational Epidemiology, Department of Social Medicine, University of Bristol, Oakfield House</s1><s2>Bristol</s2><s3>GBR</s3><sZ>5 aut.</sZ><sZ>30 aut.</sZ><sZ>32 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Froguel, Philippe" sort="Froguel, Philippe" uniqKey="Froguel P" first="Philippe" last="Froguel">Philippe Froguel</name><affiliation><inist:fA14 i1="25"><s1>Centre<sub> </sub>National de la Recherche Scientifique, UMR 8199, Institute of Biology, Pasteur Institute of Lille</s1><s2>Lille</s2><s3>FRA</s3><sZ>23 aut.</sZ><sZ>31 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Glaser, Beate" sort="Glaser, Beate" uniqKey="Glaser B" first="Beate" last="Glaser">Beate Glaser</name><affiliation><inist:fA14 i1="08"><s1>The Medical Research Council (MRC) Centre for Causal Analyses in Translational Epidemiology, Department of Social Medicine, University of Bristol, Oakfield House</s1><s2>Bristol</s2><s3>GBR</s3><sZ>5 aut.</sZ><sZ>30 aut.</sZ><sZ>32 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Groves, Christopher J" sort="Groves, Christopher J" uniqKey="Groves C" first="Christopher J." last="Groves">Christopher J. Groves</name><affiliation><inist:fA14 i1="06"><s1>Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford</s1><s3>GBR</s3><sZ>4 aut.</sZ><sZ>15 aut.</sZ><sZ>21 aut.</sZ><sZ>33 aut.</sZ><sZ>35 aut.</sZ><sZ>43 aut.</sZ><sZ>50 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Hartikainen, Anna Liisa" sort="Hartikainen, Anna Liisa" uniqKey="Hartikainen A" first="Anna-Liisa" last="Hartikainen">Anna-Liisa Hartikainen</name></author><author><name sortKey="Hassanali, Neelam" sort="Hassanali, Neelam" uniqKey="Hassanali N" first="Neelam" last="Hassanali">Neelam Hassanali</name><affiliation><inist:fA14 i1="06"><s1>Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford</s1><s3>GBR</s3><sZ>4 aut.</sZ><sZ>15 aut.</sZ><sZ>21 aut.</sZ><sZ>33 aut.</sZ><sZ>35 aut.</sZ><sZ>43 aut.</sZ><sZ>50 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Hirschhorn, Joel N" sort="Hirschhorn, Joel N" uniqKey="Hirschhorn J" first="Joel N." last="Hirschhorn">Joel N. Hirschhorn</name><affiliation><inist:fA14 i1="20"><s1>Division of Genetics, Program in Genomics, Children's Hospital</s1><s2>Boston, Massachusetts</s2><s3>USA</s3><sZ>17 aut.</sZ><sZ>36 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation><inist:fA14 i1="03"><s1>Department of Epidemiology, Erasmus Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>2 aut.</sZ><sZ>20 aut.</sZ><sZ>37 aut.</sZ><sZ>52 aut.</sZ><sZ>56 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Holly, Jeff M P" sort="Holly, Jeff M P" uniqKey="Holly J" first="Jeff M. P." last="Holly">Jeff M. P. Holly</name></author><author><name sortKey="Hypponen, Elina" sort="Hypponen, Elina" uniqKey="Hypponen E" first="Elina" last="Hyppönen">Elina Hyppönen</name><affiliation><inist:fA14 i1="09"><s1>Centre for Paediatric Epidemiology and Biostatistics, MRC Centre of Epidemiology for Child Health, University College of London Institute of Child Health</s1><s2>London</s2><s3>GBR</s3><sZ>6 aut.</sZ><sZ>39 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Kanoni, Stavroula" sort="Kanoni, Stavroula" uniqKey="Kanoni S" first="Stavroula" last="Kanoni">Stavroula Kanoni</name></author><author><name sortKey="Knight, Bridget A" sort="Knight, Bridget A" uniqKey="Knight B" first="Bridget A." last="Knight">Bridget A. Knight</name></author><author><name sortKey="Laitinen, Jaana" sort="Laitinen, Jaana" uniqKey="Laitinen J" first="Jaana" last="Laitinen">Jaana Laitinen</name></author><author><name sortKey="Lindgren, Cecilia M" sort="Lindgren, Cecilia M" uniqKey="Lindgren C" first="Cecilia M." last="Lindgren">Cecilia M. Lindgren</name><affiliation><inist:fA14 i1="06"><s1>Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford</s1><s3>GBR</s3><sZ>4 aut.</sZ><sZ>15 aut.</sZ><sZ>21 aut.</sZ><sZ>33 aut.</sZ><sZ>35 aut.</sZ><sZ>43 aut.</sZ><sZ>50 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="07"><s1>Wellcome Trust Centre for Human Genetics, University of Oxford</s1><s2>Oxford</s2><s3>GBR</s3><sZ>15 aut.</sZ><sZ>43 aut.</sZ><sZ>50 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Mcardle, Wendy L" sort="Mcardle, Wendy L" uniqKey="Mcardle W" first="Wendy L." last="Mcardle">Wendy L. Mcardle</name></author><author><name sortKey="O Reilly, Paul F" sort="O Reilly, Paul F" uniqKey="O Reilly P" first="Paul F." last="O'Reilly">Paul F. O'Reilly</name><affiliation><inist:fA14 i1="05"><s1>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London</s1><s2>London</s2><s3>GBR</s3><sZ>3 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>29 aut.</sZ><sZ>45 aut.</sZ><sZ>49 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Pennell, Craig E" sort="Pennell, Craig E" uniqKey="Pennell C" first="Craig E." last="Pennell">Craig E. Pennell</name></author><author><name sortKey="Postma, Dirkje S" sort="Postma, Dirkje S" uniqKey="Postma D" first="Dirkje S." last="Postma">Dirkje S. Postma</name></author><author><name sortKey="Pouta, Anneli" sort="Pouta, Anneli" uniqKey="Pouta A" first="Anneli" last="Pouta">Anneli Pouta</name></author><author><name sortKey="Ramasamy, Adaikalavan" sort="Ramasamy, Adaikalavan" uniqKey="Ramasamy A" first="Adaikalavan" last="Ramasamy">Adaikalavan Ramasamy</name><affiliation><inist:fA14 i1="05"><s1>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London</s1><s2>London</s2><s3>GBR</s3><sZ>3 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>29 aut.</sZ><sZ>45 aut.</sZ><sZ>49 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Rayner, Nigel W" sort="Rayner, Nigel W" uniqKey="Rayner N" first="Nigel W." last="Rayner">Nigel W. Rayner</name><affiliation><inist:fA14 i1="06"><s1>Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford</s1><s3>GBR</s3><sZ>4 aut.</sZ><sZ>15 aut.</sZ><sZ>21 aut.</sZ><sZ>33 aut.</sZ><sZ>35 aut.</sZ><sZ>43 aut.</sZ><sZ>50 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="07"><s1>Wellcome Trust Centre for Human Genetics, University of Oxford</s1><s2>Oxford</s2><s3>GBR</s3><sZ>15 aut.</sZ><sZ>43 aut.</sZ><sZ>50 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Ring, Susan M" sort="Ring, Susan M" uniqKey="Ring S" first="Susan M." last="Ring">Susan M. Ring</name></author><author><name sortKey="Rivadeneira, Fernando" sort="Rivadeneira, Fernando" uniqKey="Rivadeneira F" first="Fernando" last="Rivadeneira">Fernando Rivadeneira</name><affiliation><inist:fA14 i1="03"><s1>Department of Epidemiology, Erasmus Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>2 aut.</sZ><sZ>20 aut.</sZ><sZ>37 aut.</sZ><sZ>52 aut.</sZ><sZ>56 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Shields, Beverley M" sort="Shields, Beverley M" uniqKey="Shields B" first="Beverley M." last="Shields">Beverley M. Shields</name></author><author><name sortKey="Strachan, David P" sort="Strachan, David P" uniqKey="Strachan D" first="David P." last="Strachan">David P. Strachan</name></author><author><name sortKey="Surakka, Ida" sort="Surakka, Ida" uniqKey="Surakka I" first="Ida" last="Surakka">Ida Surakka</name><affiliation><inist:fA14 i1="11"><s1>Institute for Molecular Medicine Finland (FIMM), University of Helsinki</s1><s2>Helsinki</s2><s3>FIN</s3><sZ>8 aut.</sZ><sZ>26 aut.</sZ><sZ>55 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Taanilal, Anja" sort="Taanilal, Anja" uniqKey="Taanilal A" first="Anja" last="Taanilal">Anja Taanilal</name><affiliation><inist:fA14 i1="03"><s1>Department of Epidemiology, Erasmus Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>2 aut.</sZ><sZ>20 aut.</sZ><sZ>37 aut.</sZ><sZ>52 aut.</sZ><sZ>56 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Tiesler, Carla" sort="Tiesler, Carla" uniqKey="Tiesler C" first="Carla" last="Tiesler">Carla Tiesler</name><affiliation><inist:fA14 i1="18"><s1>Helmholtz Zentrum Muenchen, German Research Centre for Environmental Health, Institute of Epidemiology</s1><s2>Neuherberg</s2><s3>DEU</s3><sZ>16 aut.</sZ><sZ>57 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="19"><s1>Ludwig-Maximilians University of Munich, Dr. von Hauner Children's Hospital</s1><s2>Munich</s2><s3>DEU</s3><sZ>16 aut.</sZ><sZ>57 aut.</sZ></inist:fA14></affiliation></author></analytic><series><title level="j" type="main">Nature genetics</title><title level="j" type="abbreviated">Nat. genet.</title><idno type="ISSN">1061-4036</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Nature genetics</title><title level="j" type="abbreviated">Nat. genet.</title><idno type="ISSN">1061-4036</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Birth weight</term><term>Fetus</term><term>Growth</term><term>Variant</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Variant</term><term>Foetus</term><term>Croissance</term><term>Poids naissance</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To identify genetic variants associated with birth weight, we meta-analyzed six genome-wide association (GWA) studies (n = 10,623 Europeans from pregnancy/birth cohorts) and followed up two lead signals in 13 replication studies (n = 27,591). rs900400 near LEER1 and CCNL1 (P = 2 x 10<sup>-35</sup>) and rs9883204 in ADCY5 (P = 7 x 10<sup>-15</sup>) were robustly associated with birth weight. Correlated SNPs in ADCY5 were recently implicated in regulation of glucose levels and susceptibility to type 2 diabetes<sup>1</sup>, providing evidence that the well-described association between lower birth weight and subsequent type 2 diabetes<sup>2,3</sup> has a genetic component, distinct from the proposed role of programming by maternal nutrition. Using data from both SNPs, we found that the 9% of Europeans carrying four birth weight-lowering alleles were, on average, 113 g (95% CI 89-137 g) lighter at birth than the 24% with zero or one alleles (P<sub>trend</sub> = 7 x 10<sup>-30</sup>). The impact on birth weight is similar to that of a mother smoking 4-5 cigarettes per day in the third trimester of pregnancy<sup>4</sup>.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>1061-4036</s0></fA01><fA02 i1="01"><s0>NGENEC</s0></fA02><fA03 i2="1"><s0>Nat. genet.</s0></fA03><fA05><s2>42</s2></fA05><fA06><s2>5</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight</s1></fA08><fA11 i1="01" i2="1"><s1>FREATHY (Rachel M.)</s1></fA11><fA11 i1="02" i2="1"><s1>MOOK-KANAMORI (Dennis O.)</s1></fA11><fA11 i1="03" i2="1"><s1>SOVIO (Ulla)</s1></fA11><fA11 i1="04" i2="1"><s1>PROKOPENKO (Inga)</s1></fA11><fA11 i1="05" i2="1"><s1>TIMPSON (Nicholas J.)</s1></fA11><fA11 i1="06" i2="1"><s1>BERRY (Diane J.)</s1></fA11><fA11 i1="07" i2="1"><s1>WARRINGTON (Nicole M.)</s1></fA11><fA11 i1="08" i2="1"><s1>WIDEN (Elisabeth)</s1></fA11><fA11 i1="09" i2="1"><s1>HOTTENGA (Jouke Jan)</s1></fA11><fA11 i1="10" i2="1"><s1>KAAKINEN (Marika)</s1></fA11><fA11 i1="11" i2="1"><s1>LANGE (Leslie A.)</s1></fA11><fA11 i1="12" i2="1"><s1>BRADFIELD (Jonathan P.)</s1></fA11><fA11 i1="13" i2="1"><s1>KERKHOF (Marjan)</s1></fA11><fA11 i1="14" i2="1"><s1>MARSH (Julie A.)</s1></fA11><fA11 i1="15" i2="1"><s1>MÄGI (Reedik)</s1></fA11><fA11 i1="16" i2="1"><s1>CHEN (Chih-Mei)</s1></fA11><fA11 i1="17" i2="1"><s1>LYON (Helen N.)</s1></fA11><fA11 i1="18" i2="1"><s1>KIRIN (Mirna)</s1></fA11><fA11 i1="19" i2="1"><s1>ADAIR (Linda S.)</s1></fA11><fA11 i1="20" i2="1"><s1>AULCHENKO (Yurii S.)</s1></fA11><fA11 i1="21" i2="1"><s1>BENNETT (Amanda J.)</s1></fA11><fA11 i1="22" i2="1"><s1>BORJA (Judith B.)</s1></fA11><fA11 i1="23" i2="1"><s1>BOUATIA-NAJI (Nabila)</s1></fA11><fA11 i1="24" i2="1"><s1>CHAROEN (Pimphen)</s1></fA11><fA11 i1="25" i2="1"><s1>COIN (Lachlan J. M.)</s1></fA11><fA11 i1="26" i2="1"><s1>COUSMINER (Diana L.)</s1></fA11><fA11 i1="27" i2="1"><s1>DE GEUS (Eco J. C.)</s1></fA11><fA11 i1="28" i2="1"><s1>DELOUKAS (Panos)</s1></fA11><fA11 i1="29" i2="1"><s1>ELLIOTT (Paul)</s1></fA11><fA11 i1="30" i2="1"><s1>EVANS (David M.)</s1></fA11><fA11 i1="31" i2="1"><s1>FROGUEL (Philippe)</s1></fA11><fA11 i1="32" i2="1"><s1>GLASER (Beate)</s1></fA11><fA11 i1="33" i2="1"><s1>GROVES (Christopher J.)</s1></fA11><fA11 i1="34" i2="1"><s1>HARTIKAINEN (Anna-Liisa)</s1></fA11><fA11 i1="35" i2="1"><s1>HASSANALI (Neelam)</s1></fA11><fA11 i1="36" i2="1"><s1>HIRSCHHORN (Joel N.)</s1></fA11><fA11 i1="37" i2="1"><s1>HOFMAN (Albert)</s1></fA11><fA11 i1="38" i2="1"><s1>HOLLY (Jeff M. P.)</s1></fA11><fA11 i1="39" i2="1"><s1>HYPPÖNEN (Elina)</s1></fA11><fA11 i1="40" i2="1"><s1>KANONI (Stavroula)</s1></fA11><fA11 i1="41" i2="1"><s1>KNIGHT (Bridget A.)</s1></fA11><fA11 i1="42" i2="1"><s1>LAITINEN (Jaana)</s1></fA11><fA11 i1="43" i2="1"><s1>LINDGREN (Cecilia M.)</s1></fA11><fA11 i1="44" i2="1"><s1>MCARDLE (Wendy L.)</s1></fA11><fA11 i1="45" i2="1"><s1>O'REILLY (Paul F.)</s1></fA11><fA11 i1="46" i2="1"><s1>PENNELL (Craig E.)</s1></fA11><fA11 i1="47" i2="1"><s1>POSTMA (Dirkje S.)</s1></fA11><fA11 i1="48" i2="1"><s1>POUTA (Anneli)</s1></fA11><fA11 i1="49" i2="1"><s1>RAMASAMY (Adaikalavan)</s1></fA11><fA11 i1="50" i2="1"><s1>RAYNER (Nigel W.)</s1></fA11><fA11 i1="51" i2="1"><s1>RING (Susan M.)</s1></fA11><fA11 i1="52" i2="1"><s1>RIVADENEIRA (Fernando)</s1></fA11><fA11 i1="53" i2="1"><s1>SHIELDS (Beverley M.)</s1></fA11><fA11 i1="54" i2="1"><s1>STRACHAN (David P.)</s1></fA11><fA11 i1="55" i2="1"><s1>SURAKKA (Ida)</s1></fA11><fA11 i1="56" i2="1"><s1>TAANILAL (Anja)</s1></fA11><fA11 i1="57" i2="1"><s1>TIESLER (Carla)</s1></fA11><fA14 i1="01"><s1>Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter</s1><s2>Exeter</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ></fA14><fA14 i1="02"><s1>Department of Pediatrics, Erasmus Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>2 aut.</sZ></fA14><fA14 i1="03"><s1>Department of Epidemiology, Erasmus Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>2 aut.</sZ><sZ>20 aut.</sZ><sZ>37 aut.</sZ><sZ>52 aut.</sZ><sZ>56 aut.</sZ></fA14><fA14 i1="04"><s1>The Generation R Study, Erasmus Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>2 aut.</sZ></fA14><fA14 i1="05"><s1>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London</s1><s2>London</s2><s3>GBR</s3><sZ>3 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>29 aut.</sZ><sZ>45 aut.</sZ><sZ>49 aut.</sZ></fA14><fA14 i1="06"><s1>Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford</s1><s3>GBR</s3><sZ>4 aut.</sZ><sZ>15 aut.</sZ><sZ>21 aut.</sZ><sZ>33 aut.</sZ><sZ>35 aut.</sZ><sZ>43 aut.</sZ><sZ>50 aut.</sZ></fA14><fA14 i1="07"><s1>Wellcome Trust Centre for Human Genetics, University of Oxford</s1><s2>Oxford</s2><s3>GBR</s3><sZ>15 aut.</sZ><sZ>43 aut.</sZ><sZ>50 aut.</sZ></fA14><fA14 i1="08"><s1>The Medical Research Council (MRC) Centre for Causal Analyses in Translational Epidemiology, Department of Social Medicine, University of Bristol, Oakfield House</s1><s2>Bristol</s2><s3>GBR</s3><sZ>5 aut.</sZ><sZ>30 aut.</sZ><sZ>32 aut.</sZ></fA14><fA14 i1="09"><s1>Centre for Paediatric Epidemiology and Biostatistics, MRC Centre of Epidemiology for Child Health, University College of London Institute of Child Health</s1><s2>London</s2><s3>GBR</s3><sZ>6 aut.</sZ><sZ>39 aut.</sZ></fA14><fA14 i1="10"><s1>Centre for Genetic Epidemiology and Biostatistics, The University of Western Australia</s1><s2>Perth, Western Australia</s2><s3>AUS</s3><sZ>7 aut.</sZ><sZ>14 aut.</sZ></fA14><fA14 i1="11"><s1>Institute for Molecular Medicine Finland (FIMM), University of Helsinki</s1><s2>Helsinki</s2><s3>FIN</s3><sZ>8 aut.</sZ><sZ>26 aut.</sZ><sZ>55 aut.</sZ></fA14><fA14 i1="12"><s1>Department of Biological Psychology, Vrije Universiteit Amsterdam</s1><s2>Amsterdam</s2><s3>NLD</s3><sZ>9 aut.</sZ><sZ>27 aut.</sZ></fA14><fA14 i1="13"><s1>Institute of Health Sciences, University of Oulu</s1><s2>Oulu</s2><s3>FIN</s3><sZ>10 aut.</sZ></fA14><fA14 i1="14"><s1>Biocenter Oulu, University of Oulu</s1><s2>Oulu</s2><s3>FIN</s3><sZ>10 aut.</sZ></fA14><fA14 i1="15"><s1>Department of Genetics, University of North Carolina</s1><s2>Chapel Hill, North Carolina</s2><s3>USA</s3><sZ>11 aut.</sZ></fA14><fA14 i1="16"><s1>Center for Applied Genomics, The Children's Hospital of Philadelphia</s1><s2>Pennsylvania</s2><s3>USA</s3><sZ>12 aut.</sZ></fA14><fA14 i1="17"><s1>Department of Epidemiology, University Medical Center Groningen, University of Groningen</s1><s2>Groningen</s2><s3>NLD</s3><sZ>13 aut.</sZ></fA14><fA14 i1="18"><s1>Helmholtz Zentrum Muenchen, German Research Centre for Environmental Health, Institute of Epidemiology</s1><s2>Neuherberg</s2><s3>DEU</s3><sZ>16 aut.</sZ><sZ>57 aut.</sZ></fA14><fA14 i1="19"><s1>Ludwig-Maximilians University of Munich, Dr. von Hauner Children's Hospital</s1><s2>Munich</s2><s3>DEU</s3><sZ>16 aut.</sZ><sZ>57 aut.</sZ></fA14><fA14 i1="20"><s1>Division of Genetics, Program in Genomics, Children's Hospital</s1><s2>Boston, Massachusetts</s2><s3>USA</s3><sZ>17 aut.</sZ><sZ>36 aut.</sZ></fA14><fA14 i1="21"><s1>Department of Pediatrics, Harvard Medical School</s1><s2>Boston, Massachusetts</s2><s3>USA</s3><sZ>17 aut.</sZ></fA14><fA14 i1="22"><s1>Centre for Population Health Sciences, University of Edinburgh</s1><s2>Edinburgh, Scotland</s2><s3>GBR</s3><sZ>18 aut.</sZ></fA14><fA14 i1="23"><s1>Department of Nutrition, University of North Carolina</s1><s2>Chapel Hill, North Carolina</s2><s3>USA</s3><sZ>19 aut.</sZ></fA14><fA14 i1="24"><s1>Office of Population Studies Foundation, University of San Carlos</s1><s2>Cebu City</s2><s3>PHL</s3><sZ>22 aut.</sZ></fA14><fA14 i1="25"><s1>Centre<sub> </sub>National de la Recherche Scientifique, UMR 8199, Institute of Biology, Pasteur Institute of Lille</s1><s2>Lille</s2><s3>FRA</s3><sZ>23 aut.</sZ><sZ>31 aut.</sZ></fA14><fA17 i1="01" i2="1"><s1>The Genetic Investigation of Anthropometric Traits (GIANT) Consortium (MAGIC) Consortium</s1><s3>INC</s3></fA17><fA20><s1>430-435</s1></fA20><fA21><s1>2010</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>22883</s2><s5>354000193914090110</s5></fA43><fA44><s0>0000</s0><s1>© 2010 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>32 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>10-0400434</s0></fA47><fA60><s1>P</s1><s3>CR</s3></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Nature genetics</s0></fA64><fA66 i1="01"><s0>USA</s0></fA66><fC01 i1="01" l="ENG"><s0>To identify genetic variants associated with birth weight, we meta-analyzed six genome-wide association (GWA) studies (n = 10,623 Europeans from pregnancy/birth cohorts) and followed up two lead signals in 13 replication studies (n = 27,591). rs900400 near LEER1 and CCNL1 (P = 2 x 10<sup>-35</sup>) and rs9883204 in ADCY5 (P = 7 x 10<sup>-15</sup>) were robustly associated with birth weight. Correlated SNPs in ADCY5 were recently implicated in regulation of glucose levels and susceptibility to type 2 diabetes<sup>1</sup>, providing evidence that the well-described association between lower birth weight and subsequent type 2 diabetes<sup>2,3</sup> has a genetic component, distinct from the proposed role of programming by maternal nutrition. Using data from both SNPs, we found that the 9% of Europeans carrying four birth weight-lowering alleles were, on average, 113 g (95% CI 89-137 g) lighter at birth than the 24% with zero or one alleles (P<sub>trend</sub> = 7 x 10<sup>-30</sup>). The impact on birth weight is similar to that of a mother smoking 4-5 cigarettes per day in the third trimester of pregnancy<sup>4</sup>.</s0></fC01><fC02 i1="01" i2="X"><s0>002A07</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Variant</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Variant</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Variante</s0><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Foetus</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Fetus</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Feto</s0><s5>02</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Croissance</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Growth</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Crecimiento</s0><s5>03</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Poids naissance</s0><s5>04</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Birth weight</s0><s5>04</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Peso nacimiento</s0><s5>04</s5></fC03><fN21><s1>256</s1></fN21><fN44 i1="01"><s1>OTO</s1></fN44><fN82><s1>OTO</s1></fN82></pA></standard><server><NO>PASCAL 10-0400434 INIST</NO><ET>Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight</ET><AU>FREATHY (Rachel M.); MOOK-KANAMORI (Dennis O.); SOVIO (Ulla); PROKOPENKO (Inga); TIMPSON (Nicholas J.); BERRY (Diane J.); WARRINGTON (Nicole M.); WIDEN (Elisabeth); HOTTENGA (Jouke Jan); KAAKINEN (Marika); LANGE (Leslie A.); BRADFIELD (Jonathan P.); KERKHOF (Marjan); MARSH (Julie A.); MÄGI (Reedik); CHEN (Chih-Mei); LYON (Helen N.); KIRIN (Mirna); ADAIR (Linda S.); AULCHENKO (Yurii S.); BENNETT (Amanda J.); BORJA (Judith B.); BOUATIA-NAJI (Nabila); CHAROEN (Pimphen); COIN (Lachlan J. M.); COUSMINER (Diana L.); DE GEUS (Eco J. C.); DELOUKAS (Panos); ELLIOTT (Paul); EVANS (David M.); FROGUEL (Philippe); GLASER (Beate); GROVES (Christopher J.); HARTIKAINEN (Anna-Liisa); HASSANALI (Neelam); HIRSCHHORN (Joel N.); HOFMAN (Albert); HOLLY (Jeff M. P.); HYPPÖNEN (Elina); KANONI (Stavroula); KNIGHT (Bridget A.); LAITINEN (Jaana); LINDGREN (Cecilia M.); MCARDLE (Wendy L.); O'REILLY (Paul F.); PENNELL (Craig E.); POSTMA (Dirkje S.); POUTA (Anneli); RAMASAMY (Adaikalavan); RAYNER (Nigel W.); RING (Susan M.); RIVADENEIRA (Fernando); SHIELDS (Beverley M.); STRACHAN (David P.); SURAKKA (Ida); TAANILAL (Anja); TIESLER (Carla)</AU><AF>Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter/Exeter/Royaume-Uni (1 aut., 4 aut.); Department of Pediatrics, Erasmus Medical Center/Rotterdam/Pays-Bas (2 aut.); Department of Epidemiology, Erasmus Medical Center/Rotterdam/Pays-Bas (2 aut., 20 aut., 37 aut., 52 aut., 56 aut.); The Generation R Study, Erasmus Medical Center/Rotterdam/Pays-Bas (2 aut.); Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London/London/Royaume-Uni (3 aut., 24 aut., 25 aut., 29 aut., 45 aut., 49 aut.); Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford/Royaume-Uni (4 aut., 15 aut., 21 aut., 33 aut., 35 aut., 43 aut., 50 aut.); Wellcome Trust Centre for Human Genetics, University of Oxford/Oxford/Royaume-Uni (15 aut., 43 aut., 50 aut.); The Medical Research Council (MRC) Centre for Causal Analyses in Translational Epidemiology, Department of Social Medicine, University of Bristol, Oakfield House/Bristol/Royaume-Uni (5 aut., 30 aut., 32 aut.); Centre for Paediatric Epidemiology and Biostatistics, MRC Centre of Epidemiology for Child Health, University College of London Institute of Child Health/London/Royaume-Uni (6 aut., 39 aut.); Centre for Genetic Epidemiology and Biostatistics, The University of Western Australia/Perth, Western Australia/Australie (7 aut., 14 aut.); Institute for Molecular Medicine Finland (FIMM), University of Helsinki/Helsinki/Finlande (8 aut., 26 aut., 55 aut.); Department of Biological Psychology, Vrije Universiteit Amsterdam/Amsterdam/Pays-Bas (9 aut., 27 aut.); Institute of Health Sciences, University of Oulu/Oulu/Finlande (10 aut.); Biocenter Oulu, University of Oulu/Oulu/Finlande (10 aut.); Department of Genetics, University of North Carolina/Chapel Hill, North Carolina/Etats-Unis (11 aut.); Center for Applied Genomics, The Children's Hospital of Philadelphia/Pennsylvania/Etats-Unis (12 aut.); Department of Epidemiology, University Medical Center Groningen, University of Groningen/Groningen/Pays-Bas (13 aut.); Helmholtz Zentrum Muenchen, German Research Centre for Environmental Health, Institute of Epidemiology/Neuherberg/Allemagne (16 aut., 57 aut.); Ludwig-Maximilians University of Munich, Dr. von Hauner Children's Hospital/Munich/Allemagne (16 aut., 57 aut.); Division of Genetics, Program in Genomics, Children's Hospital/Boston, Massachusetts/Etats-Unis (17 aut., 36 aut.); Department of Pediatrics, Harvard Medical School/Boston, Massachusetts/Etats-Unis (17 aut.); Centre for Population Health Sciences, University of Edinburgh/Edinburgh, Scotland/Royaume-Uni (18 aut.); Department of Nutrition, University of North Carolina/Chapel Hill, North Carolina/Etats-Unis (19 aut.); Office of Population Studies Foundation, University of San Carlos/Cebu City/Philippines (22 aut.); Centre<sub> </sub>National de la Recherche Scientifique, UMR 8199, Institute of Biology, Pasteur Institute of Lille/Lille/France (23 aut., 31 aut.)</AF><DT>Publication en série; Correspondance, lettre; Niveau analytique</DT><SO>Nature genetics; ISSN 1061-4036; Coden NGENEC; Etats-Unis; Da. 2010; Vol. 42; No. 5; Pp. 430-435; Bibl. 32 ref.</SO><LA>Anglais</LA><EA>To identify genetic variants associated with birth weight, we meta-analyzed six genome-wide association (GWA) studies (n = 10,623 Europeans from pregnancy/birth cohorts) and followed up two lead signals in 13 replication studies (n = 27,591). rs900400 near LEER1 and CCNL1 (P = 2 x 10<sup>-35</sup>) and rs9883204 in ADCY5 (P = 7 x 10<sup>-15</sup>) were robustly associated with birth weight. Correlated SNPs in ADCY5 were recently implicated in regulation of glucose levels and susceptibility to type 2 diabetes<sup>1</sup>, providing evidence that the well-described association between lower birth weight and subsequent type 2 diabetes<sup>2,3</sup> has a genetic component, distinct from the proposed role of programming by maternal nutrition. Using data from both SNPs, we found that the 9% of Europeans carrying four birth weight-lowering alleles were, on average, 113 g (95% CI 89-137 g) lighter at birth than the 24% with zero or one alleles (P<sub>trend</sub> = 7 x 10<sup>-30</sup>). The impact on birth weight is similar to that of a mother smoking 4-5 cigarettes per day in the third trimester of pregnancy<sup>4</sup>.</EA><CC>002A07</CC><FD>Variant; Foetus; Croissance; Poids naissance</FD><ED>Variant; Fetus; Growth; Birth weight</ED><SD>Variante; Feto; Crecimiento; Peso nacimiento</SD><LO>INIST-22883.354000193914090110</LO><ID>10-0400434</ID></server></inist></record>Pour manipuler ce document sous Unix (Dilib)
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