Lung Function, Airway Inflammation, and Polycyclic Aromatic Hydrocarbons Exposure in Mexican Schoolchildren: A Pilot Study
Identifieur interne : 004070 ( Main/Exploration ); précédent : 004069; suivant : 004071Lung Function, Airway Inflammation, and Polycyclic Aromatic Hydrocarbons Exposure in Mexican Schoolchildren: A Pilot Study
Auteurs : Albino Barraza-Villarreal [Mexique] ; Maria Consuelo Escamilla-Nunez [Mexique] ; Astrid Schilmann [Mexique] ; Leticia Hernandez-Cadena [Mexique] ; ZHENG LI [États-Unis] ; Lovisa Romanoff [États-Unis] ; Andreas Sjödin [États-Unis] ; Blanca Estela Del Rio-Navarro [Mexique] ; David Diaz-Sanchez [États-Unis] ; Fernando Diaz-Barriga [Mexique] ; Peter Sly [Australie] ; Isabelle Romieu [Mexique, France]Source :
- Journal of occupational and environmental medicine [ 1076-2752 ] ; 2014.
Descripteurs français
- KwdFr :
- Adolescent, Enfant, Enquêtes et questionnaires, Exposition environnementale (effets indésirables), Facteurs de risque, Femelle, Humains, Hydrocarbures aromatiques polycycliques (toxicité), Hydrocarbures aromatiques polycycliques (urine), Marqueurs biologiques (urine), Mexique (épidémiologie), Mâle, Projets pilotes, Tests de la fonction respiratoire, Études transversales.
- MESH :
- effets indésirables : Exposition environnementale.
- toxicité : Hydrocarbures aromatiques polycycliques.
- urine : Hydrocarbures aromatiques polycycliques, Marqueurs biologiques.
- épidémiologie : Mexique.
- Pascal (Inist)
- Adolescent, Composé aromatique polycyclique, Enfant, Enquêtes et questionnaires, Facteurs de risque, Femelle, Fonction respiratoire, Humains, Mâle, Projets pilotes, Tests de la fonction respiratoire, Voie respiratoire, Hydrocarbure, Inflammation, Carcinogène, Exposition, Mexique, Enfant, Age scolaire, Essai pilote, Epidémiologie, Santé publique, Enquête pilote, Etude pilote, Études transversales.
- Wicri :
- geographic : Mexique.
- topic : Hydrocarbure, Enfant, Santé publique.
English descriptors
- KwdEn :
- Adolescent, Biomarkers (urine), Carcinogen, Child, Cross-Sectional Studies, Environmental Exposure (adverse effects), Epidemiology, Exposure, Female, Humans, Hydrocarbon, Inflammation, Lung function, Male, Mexico, Mexico (epidemiology), Pilot Projects, Pilot test, Polycyclic Aromatic Hydrocarbons (toxicity), Polycyclic Aromatic Hydrocarbons (urine), Polycyclic aromatic compound, Public health, Respiratory Function Tests, Respiratory tract, Risk Factors, School age, Surveys and Questionnaires.
- MESH :
- chemical , toxicity : Polycyclic Aromatic Hydrocarbons.
- chemical , urine : Biomarkers, Polycyclic Aromatic Hydrocarbons.
- adverse effects : Environmental Exposure.
- epidemiology : Mexico.
- Adolescent, Child, Cross-Sectional Studies, Female, Humans, Male, Pilot Projects, Respiratory Function Tests, Risk Factors, Surveys and Questionnaires.
Abstract
Objective: To determine the association of exposure to polycyclic aromatic hydrocarbons (PAHs) with lung function and pH of exhaled breath condensate (EBC) in Mexican schoolchildren. Methods: A pilot study was performed in a subsample of 64 schoolchildren from Mexico City. Lung function and pH of EBC were measured and metabolites of PAHs in urine samples were determined. The association was analyzed using robust regression models. Results: A 10% increase in the concentrations of 2-hydroxyfluorene was significantly negatively associated with forced expiratory volume in 1 second (-11.2 mL, 95% CI: -22.2 to -0.02), forced vital capacity (-11.6 mL, 95% CI: -22.9 to -0.2), and pH of EBC (-0.035, 95% CI: -0.066 to -0.005). Conclusion: Biomarkers of PAHs exposure were inversely associated with lung function and decrease of ph of EBC as a marker of airway inflammation in Mexican schoolchildren.
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Affiliations:
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aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Mexique</country><wicri:noRegion>National Institute of Public Health</wicri:noRegion></affiliation></author><author><name sortKey="Escamilla Nunez, Maria Consuelo" sort="Escamilla Nunez, Maria Consuelo" uniqKey="Escamilla Nunez M" first="Maria Consuelo" last="Escamilla-Nunez">Maria Consuelo Escamilla-Nunez</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>National Institute of Public Health</s1><s2>Cuernavaca, Morelos</s2><s3>MEX</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Mexique</country><wicri:noRegion>National Institute of Public Health</wicri:noRegion></affiliation></author><author><name sortKey="Schilmann, Astrid" sort="Schilmann, Astrid" uniqKey="Schilmann A" first="Astrid" last="Schilmann">Astrid Schilmann</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>National Institute of Public Health</s1><s2>Cuernavaca, Morelos</s2><s3>MEX</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Mexique</country><wicri:noRegion>National Institute of Public Health</wicri:noRegion></affiliation></author><author><name sortKey="Hernandez Cadena, Leticia" sort="Hernandez Cadena, Leticia" uniqKey="Hernandez Cadena L" first="Leticia" last="Hernandez-Cadena">Leticia Hernandez-Cadena</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>National Institute of Public Health</s1><s2>Cuernavaca, Morelos</s2><s3>MEX</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Mexique</country><wicri:noRegion>National Institute of Public Health</wicri:noRegion></affiliation></author><author><name sortKey="Zheng Li" sort="Zheng Li" uniqKey="Zheng Li" last="Zheng Li">ZHENG LI</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Centers for Disease Control & Prevention</s1><s2>Atlanta, Ga</s2><s3>USA</s3><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Centers for Disease Control & Prevention</wicri:noRegion></affiliation></author><author><name sortKey="Romanoff, Lovisa" sort="Romanoff, Lovisa" uniqKey="Romanoff L" first="Lovisa" last="Romanoff">Lovisa Romanoff</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Centers for Disease Control & Prevention</s1><s2>Atlanta, Ga</s2><s3>USA</s3><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Centers for Disease Control & Prevention</wicri:noRegion></affiliation></author><author><name sortKey="Sjodin, Andreas" sort="Sjodin, Andreas" uniqKey="Sjodin A" first="Andreas" last="Sjödin">Andreas Sjödin</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Centers for Disease Control & Prevention</s1><s2>Atlanta, Ga</s2><s3>USA</s3><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Centers for Disease Control & Prevention</wicri:noRegion></affiliation></author><author><name sortKey="Del Rio Navarro, Blanca Estela" sort="Del Rio Navarro, Blanca Estela" uniqKey="Del Rio Navarro B" first="Blanca Estela" last="Del Rio-Navarro">Blanca Estela Del Rio-Navarro</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Hospital Infantil de Mexico Federico Gomez</s1><s2>Mexico DF</s2><s3>MEX</s3><sZ>8 aut.</sZ></inist:fA14><country>Mexique</country><wicri:noRegion>Hospital Infantil de Mexico Federico Gomez</wicri:noRegion></affiliation></author><author><name sortKey="Diaz Sanchez, David" sort="Diaz Sanchez, David" uniqKey="Diaz Sanchez D" first="David" last="Diaz-Sanchez">David Diaz-Sanchez</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>United States Environmental Protection Agency</s1><s2>Research Triangle Park, NC</s2><s3>USA</s3><sZ>9 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>United States Environmental Protection Agency</wicri:noRegion></affiliation></author><author><name sortKey="Diaz Barriga, Fernando" sort="Diaz Barriga, Fernando" uniqKey="Diaz Barriga F" first="Fernando" last="Diaz-Barriga">Fernando Diaz-Barriga</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Universidad Autónoma de San Luis Potosi</s1><s2>San Luis Potosi</s2><s3>MEX</s3><sZ>10 aut.</sZ></inist:fA14><country>Mexique</country><wicri:noRegion>Universidad Autónoma de San Luis Potosi</wicri:noRegion></affiliation></author><author><name sortKey="Sly, Peter" sort="Sly, Peter" uniqKey="Sly P" first="Peter" last="Sly">Peter Sly</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Division of Clinical Sciences, Telethon Institute for Child Health Research and Centre for Child Health Research, University of Western Australia</s1><s2>Perth</s2><s3>AUS</s3><sZ>11 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xml:lang="en"><term>Polycyclic Aromatic Hydrocarbons</term></keywords><keywords scheme="MESH" type="chemical" qualifier="urine" xml:lang="en"><term>Biomarkers</term><term>Polycyclic Aromatic Hydrocarbons</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Environmental Exposure</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Exposition environnementale</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Mexico</term></keywords><keywords scheme="MESH" qualifier="toxicité" xml:lang="fr"><term>Hydrocarbures aromatiques polycycliques</term></keywords><keywords scheme="MESH" qualifier="urine" xml:lang="fr"><term>Hydrocarbures aromatiques polycycliques</term><term>Marqueurs biologiques</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Mexique</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Child</term><term>Cross-Sectional Studies</term><term>Female</term><term>Humans</term><term>Male</term><term>Pilot Projects</term><term>Respiratory Function Tests</term><term>Risk Factors</term><term>Surveys and Questionnaires</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Adolescent</term><term>Composé aromatique polycyclique</term><term>Enfant</term><term>Enquêtes et questionnaires</term><term>Facteurs de risque</term><term>Femelle</term><term>Fonction respiratoire</term><term>Humains</term><term>Mâle</term><term>Projets pilotes</term><term>Tests de la fonction respiratoire</term><term>Voie respiratoire</term><term>Hydrocarbure</term><term>Inflammation</term><term>Carcinogène</term><term>Exposition</term><term>Mexique</term><term>Enfant</term><term>Age scolaire</term><term>Essai pilote</term><term>Epidémiologie</term><term>Santé publique</term><term>Enquête pilote</term><term>Etude pilote</term><term>Études transversales</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Mexique</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Hydrocarbure</term><term>Enfant</term><term>Santé publique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Objective: To determine the association of exposure to polycyclic aromatic hydrocarbons (PAHs) with lung function and pH of exhaled breath condensate (EBC) in Mexican schoolchildren. Methods: A pilot study was performed in a subsample of 64 schoolchildren from Mexico City. Lung function and pH of EBC were measured and metabolites of PAHs in urine samples were determined. The association was analyzed using robust regression models. Results: A 10% increase in the concentrations of 2-hydroxyfluorene was significantly negatively associated with forced expiratory volume in 1 second (-11.2 mL, 95% CI: -22.2 to -0.02), forced vital capacity (-11.6 mL, 95% CI: -22.9 to -0.2), and pH of EBC (-0.035, 95% CI: -0.066 to -0.005). Conclusion: Biomarkers of PAHs exposure were inversely associated with lung function and decrease of ph of EBC as a marker of airway inflammation in Mexican schoolchildren.</div></front></TEI><affiliations><list><country><li>Australie</li><li>France</li><li>Mexique</li><li>États-Unis</li></country><region><li>Auvergne-Rhône-Alpes</li><li>Rhône-Alpes</li></region><settlement><li>Lyon</li></settlement></list><tree><country name="Mexique"><noRegion><name sortKey="Barraza Villarreal, Albino" sort="Barraza Villarreal, Albino" uniqKey="Barraza Villarreal A" first="Albino" last="Barraza-Villarreal">Albino Barraza-Villarreal</name></noRegion><name sortKey="Del Rio Navarro, Blanca Estela" sort="Del Rio Navarro, Blanca Estela" uniqKey="Del Rio Navarro B" first="Blanca Estela" last="Del Rio-Navarro">Blanca Estela Del Rio-Navarro</name><name sortKey="Diaz Barriga, Fernando" sort="Diaz Barriga, Fernando" uniqKey="Diaz Barriga F" first="Fernando" last="Diaz-Barriga">Fernando Diaz-Barriga</name><name sortKey="Escamilla Nunez, Maria Consuelo" sort="Escamilla Nunez, Maria Consuelo" uniqKey="Escamilla Nunez M" first="Maria Consuelo" last="Escamilla-Nunez">Maria Consuelo Escamilla-Nunez</name><name sortKey="Hernandez Cadena, Leticia" sort="Hernandez Cadena, Leticia" uniqKey="Hernandez Cadena L" first="Leticia" last="Hernandez-Cadena">Leticia Hernandez-Cadena</name><name sortKey="Romieu, Isabelle" sort="Romieu, Isabelle" uniqKey="Romieu I" first="Isabelle" last="Romieu">Isabelle Romieu</name><name sortKey="Schilmann, Astrid" sort="Schilmann, Astrid" uniqKey="Schilmann A" first="Astrid" last="Schilmann">Astrid Schilmann</name></country><country name="États-Unis"><noRegion><name sortKey="Zheng Li" sort="Zheng Li" uniqKey="Zheng Li" last="Zheng Li">ZHENG LI</name></noRegion><name sortKey="Diaz Sanchez, David" sort="Diaz Sanchez, David" uniqKey="Diaz Sanchez D" first="David" last="Diaz-Sanchez">David Diaz-Sanchez</name><name sortKey="Romanoff, Lovisa" sort="Romanoff, Lovisa" uniqKey="Romanoff L" first="Lovisa" last="Romanoff">Lovisa Romanoff</name><name sortKey="Sjodin, Andreas" sort="Sjodin, Andreas" uniqKey="Sjodin A" first="Andreas" last="Sjödin">Andreas Sjödin</name></country><country name="Australie"><noRegion><name sortKey="Sly, Peter" sort="Sly, Peter" uniqKey="Sly P" first="Peter" last="Sly">Peter Sly</name></noRegion></country><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Romieu, Isabelle" sort="Romieu, Isabelle" uniqKey="Romieu I" first="Isabelle" last="Romieu">Isabelle Romieu</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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