Lung Function, Airway Inflammation, and Polycyclic Aromatic Hydrocarbons Exposure in Mexican Schoolchildren
Identifieur interne : 003777 ( Main/Merge ); précédent : 003776; suivant : 003778Lung Function, Airway Inflammation, and Polycyclic Aromatic Hydrocarbons Exposure in Mexican Schoolchildren
Auteurs : Albino Barraza-Villarreal ; Maria Consuelo Escamilla-Nu Ez ; Astrid Schilmann ; Leticia Hernandez-Cadena ; Zheng Li ; Lovisa Romanoff ; Andreas Sjödin ; Blanca Estela Del Río-Navarro ; David Díaz-Sanchez ; Fernando Díaz-Barriga ; Peter Sly ; Isabelle RomieuSource :
- Journal of occupational and environmental medicine / American College of Occupational and Environmental Medicine [ 1076-2752 ] ; 2014.
Descripteurs français
- KwdFr :
- Adolescent, Enfant, Enquêtes et questionnaires, Exposition environnementale (effets indésirables), Facteurs de risque, Femelle, Humains, Hydrocarbures aromatiques polycycliques (toxicité), Hydrocarbures aromatiques polycycliques (urine), Marqueurs biologiques (urine), Mexique (épidémiologie), Mâle, Projets pilotes, Tests de la fonction respiratoire, Études transversales.
- MESH :
- effets indésirables : Exposition environnementale.
- toxicité : Hydrocarbures aromatiques polycycliques.
- urine : Hydrocarbures aromatiques polycycliques, Marqueurs biologiques.
- épidémiologie : Mexique.
- Adolescent, Enfant, Enquêtes et questionnaires, Facteurs de risque, Femelle, Humains, Mâle, Projets pilotes, Tests de la fonction respiratoire, Études transversales.
English descriptors
- KwdEn :
- Adolescent, Biomarkers (urine), Child, Cross-Sectional Studies, Environmental Exposure (adverse effects), Female, Humans, Male, Mexico (epidemiology), Pilot Projects, Polycyclic Aromatic Hydrocarbons (toxicity), Polycyclic Aromatic Hydrocarbons (urine), Respiratory Function Tests, Risk Factors, Surveys and Questionnaires.
- MESH :
- chemical , toxicity : Polycyclic Aromatic Hydrocarbons.
- chemical , urine : Biomarkers, Polycyclic Aromatic Hydrocarbons.
- adverse effects : Environmental Exposure.
- epidemiology : Mexico.
- Adolescent, Child, Cross-Sectional Studies, Female, Humans, Male, Pilot Projects, Respiratory Function Tests, Risk Factors, Surveys and Questionnaires.
Abstract
To determine the association of exposure to polycyclic aromatic hydrocarbons (PAHs) with lung function and pH of exhaled breath condensate (EBC) in Mexican schoolchildren.
A pilot study was performed in a subsample of 64 schoolchildren from Mexico City. Lung function and pH of EBC were measured and metabolites of PAHs in urine samples were determined. The association was analyzed using robust regression models.
A 10% increase in the concentrations of 2-hydroxyfluorene was significantly negatively associated with forced expiratory volume in 1 second (−11.2 mL, 95% CI: −22.2 to −0.02), forced vital capacity (−11.6 mL, 95% CI: −22.9 to −0.2), and pH of EBC (−0.035, 95% CI: −0.066 to −0.005).
Biomarkers of PAHs exposure were inversely associated with lung function and decrease of ph of EBC as a marker of airway inflammation in Mexican schoolchildren.
Url:
DOI: 10.1097/JOM.0000000000000111
PubMed: 24500378
PubMed Central: 4604599
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PMC:4604599Le document en format XML
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medicine / American College of Occupational and Environmental Medicine</title><idno type="ISSN">1076-2752</idno><idno type="eISSN">1536-5948</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Biomarkers (urine)</term><term>Child</term><term>Cross-Sectional Studies</term><term>Environmental Exposure (adverse effects)</term><term>Female</term><term>Humans</term><term>Male</term><term>Mexico (epidemiology)</term><term>Pilot Projects</term><term>Polycyclic Aromatic Hydrocarbons (toxicity)</term><term>Polycyclic Aromatic Hydrocarbons (urine)</term><term>Respiratory Function Tests</term><term>Risk Factors</term><term>Surveys and Questionnaires</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Enfant</term><term>Enquêtes et questionnaires</term><term>Exposition environnementale (effets indésirables)</term><term>Facteurs 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respiratoire</term><term>Études transversales</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Objective</title><p id="P1">To determine the association of exposure to polycyclic aromatic hydrocarbons (PAHs) with lung function and pH of exhaled breath condensate (EBC) in Mexican schoolchildren.</p></sec><sec id="S2"><title>Methods</title><p id="P2">A pilot study was performed in a subsample of 64 schoolchildren from Mexico City. Lung function and pH of EBC were measured and metabolites of PAHs in urine samples were determined. The association was analyzed using robust regression models.</p></sec><sec id="S3"><title>Results</title><p id="P3">A 10% increase in the concentrations of 2-hydroxyfluorene was significantly negatively associated with forced expiratory volume in 1 second (−11.2 mL, 95% CI: −22.2 to −0.02), forced vital capacity (−11.6 mL, 95% CI: −22.9 to −0.2), and pH of EBC (−0.035, 95% CI: −0.066 to −0.005).</p></sec><sec id="S4"><title>Conclusion</title><p id="P4">Biomarkers of PAHs exposure were inversely associated with lung function and decrease of ph of EBC as a marker of airway inflammation in Mexican schoolchildren.</p></sec></div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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