Local dose enhancement of proton therapy by ceramic oxide nanoparticles investigated with Geant4 simulations.
Identifieur interne : 001B86 ( Main/Curation ); précédent : 001B85; suivant : 001B87Local dose enhancement of proton therapy by ceramic oxide nanoparticles investigated with Geant4 simulations.
Auteurs : Sally Mckinnon [Australie] ; Susanna Guatelli [Australie] ; Sebastien Incerti [France] ; Vladimir Ivanchenko [Russie] ; Konstantin Konstantinov [Australie] ; Stéphanie Corde [Australie] ; Michael Lerch [Australie] ; Moeava Tehei [Australie] ; Anatoly Rosenfeld [Australie]Source :
- Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB) [ 1724-191X ] ; 2016.
Descripteurs français
- KwdFr :
- Cérium (), Cérium (pharmacologie), Dose de radiation, Dosimétrie en radiothérapie, Humains, Mâle, Méthode de Monte-Carlo, Nanoparticules, Nanoparticules métalliques (), Or (), Oxydes (), Oxydes (pharmacologie), Protonthérapie (), Tantale (), Tantale (pharmacologie), Tumeurs de la prostate (radiothérapie).
- MESH :
- pharmacologie : Cérium, Oxydes, Tantale.
- radiothérapie : Tumeurs de la prostate.
- Cérium, Dose de radiation, Dosimétrie en radiothérapie, Humains, Mâle, Méthode de Monte-Carlo, Nanoparticules, Nanoparticules métalliques, Or, Oxydes, Protonthérapie, Tantale.
English descriptors
- KwdEn :
- Cerium (chemistry), Cerium (pharmacology), Gold (chemistry), Humans, Male, Metal Nanoparticles (chemistry), Monte Carlo Method, Nanoparticles, Oxides (chemistry), Oxides (pharmacology), Prostatic Neoplasms (radiotherapy), Proton Therapy (methods), Radiation Dosage, Radiotherapy Dosage, Tantalum (chemistry), Tantalum (pharmacology).
- MESH :
- chemical , chemistry : Cerium, Gold, Oxides, Tantalum.
- chemical , pharmacology : Cerium, Oxides, Tantalum.
- chemistry : Metal Nanoparticles.
- methods : Proton Therapy.
- radiotherapy : Prostatic Neoplasms.
- Humans, Male, Monte Carlo Method, Nanoparticles, Radiation Dosage, Radiotherapy Dosage.
Abstract
Nanoparticles (NPs) have been shown to enhance X-ray radiotherapy and proton therapy of cancer. The effectiveness of radiation damage is enhanced in the presence of high atomic number (high-Z) NPs due to increased production of low energy, higher linear energy transfer (LET) secondary electrons when NPs are selectively internalized by tumour cells. This work quantifies the local dose enhancement produced by the high-Z ceramic oxide NPs Ta2O5 and CeO2, in the target tumour, for the first time in proton therapy, by means of Geant4 simulations. The dose enhancement produced by the ceramic oxides is compared against gold NPs. The energy deposition on a nanoscale around a single nanoparticle of 100nm diameter is investigated using the Geant4-DNA extension to model particle interactions in the water medium. Enhancement of energy deposition in nano-sized shells of water, local to the NP boundary, ranging between 14% and 27% was observed for proton energies of 5MeV and 50MeV, depending on the NP material. Enhancement of electron production and energy deposition can be correlated to the direct DNA damage mechanism if the NP is in close proximity to the nucleus.
DOI: 10.1016/j.ejmp.2016.11.112
PubMed: 27916516
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pubmed:27916516Le document en format XML
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Radiation Oncology Department, Prince of Wales Hospital, Randwick, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Medical Radiation Physics, University of Wollongong, NSW, Australia; Radiation Oncology Department, Prince of Wales Hospital, Randwick, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author><author><name sortKey="Lerch, Michael" sort="Lerch, Michael" uniqKey="Lerch M" first="Michael" last="Lerch">Michael Lerch</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Medical Radiation Physics, University of Wollongong, NSW, Australia; Illawarra Health and Medical Research Institute, University of Wollongong, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Medical Radiation Physics, University of Wollongong, NSW, Australia; Illawarra Health and Medical Research Institute, University of Wollongong, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author><author><name sortKey="Tehei, Moeava" sort="Tehei, Moeava" uniqKey="Tehei M" first="Moeava" last="Tehei">Moeava Tehei</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Medical Radiation Physics, University of Wollongong, NSW, Australia; Illawarra Health and Medical Research Institute, University of Wollongong, NSW, Australia; Centre for Medical and Molecular Bioscience, University of Wollongong, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Medical Radiation Physics, University of Wollongong, NSW, Australia; Illawarra Health and Medical Research Institute, University of Wollongong, NSW, Australia; Centre for Medical and Molecular Bioscience, University of Wollongong, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author><author><name sortKey="Rosenfeld, Anatoly" sort="Rosenfeld, Anatoly" uniqKey="Rosenfeld A" first="Anatoly" last="Rosenfeld">Anatoly Rosenfeld</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Medical Radiation Physics, University of Wollongong, NSW, Australia; Illawarra Health and Medical Research Institute, University of Wollongong, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Medical Radiation Physics, University of Wollongong, NSW, Australia; 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Illawarra Health and Medical Research Institute, University of Wollongong, NSW, Australia. Electronic address: susanna@uow.edu.au.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Medical Radiation Physics, University of Wollongong, NSW, Australia; Illawarra Health and Medical Research Institute, University of Wollongong, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author><author><name sortKey="Incerti, Sebastien" sort="Incerti, Sebastien" uniqKey="Incerti S" first="Sebastien" last="Incerti">Sebastien Incerti</name><affiliation wicri:level="1"><nlm:affiliation>CNRS/IN2P3, Centre d'Etudes Nucléaires de Bordeaux-Gradignan, UMR-5797, chemin du solarium, 33175 Gradignan, France; Université Bordeaux, Centre d'Etudes Nucléaires de Bordeaux-Gradignan, UMR-5797, chemin du solarium, 33175 Gradignan, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CNRS/IN2P3, Centre d'Etudes Nucléaires de Bordeaux-Gradignan, UMR-5797, chemin du solarium, 33175 Gradignan, France; Université Bordeaux, Centre d'Etudes Nucléaires de Bordeaux-Gradignan, UMR-5797, chemin du solarium, 33175 Gradignan</wicri:regionArea><wicri:noRegion>33175 Gradignan</wicri:noRegion><wicri:noRegion>33175 Gradignan</wicri:noRegion></affiliation></author><author><name sortKey="Ivanchenko, Vladimir" sort="Ivanchenko, Vladimir" uniqKey="Ivanchenko V" first="Vladimir" last="Ivanchenko">Vladimir Ivanchenko</name><affiliation wicri:level="1"><nlm:affiliation>Geant4 Associates International Ltd, United Kingdom; Ecoanalytica, 119899 Moscow, Russian Federation.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Geant4 Associates International Ltd, United Kingdom; Ecoanalytica, 119899 Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Konstantinov, Konstantin" sort="Konstantinov, Konstantin" uniqKey="Konstantinov K" first="Konstantin" last="Konstantinov">Konstantin Konstantinov</name><affiliation wicri:level="1"><nlm:affiliation>Illawarra Health and Medical Research Institute, University of Wollongong, NSW, Australia; Institute for Superconducting and Electronic Materials, University of Wollongong, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Illawarra Health and Medical Research Institute, University of Wollongong, NSW, Australia; Institute for Superconducting and Electronic Materials, University of Wollongong, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author><author><name sortKey="Corde, Stephanie" sort="Corde, Stephanie" uniqKey="Corde S" first="Stéphanie" last="Corde">Stéphanie Corde</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Medical Radiation Physics, University of Wollongong, NSW, Australia; Radiation Oncology Department, Prince of Wales Hospital, Randwick, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Medical Radiation Physics, University of Wollongong, NSW, Australia; Radiation Oncology Department, Prince of Wales Hospital, Randwick, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author><author><name sortKey="Lerch, Michael" sort="Lerch, Michael" uniqKey="Lerch M" first="Michael" last="Lerch">Michael Lerch</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Medical Radiation Physics, University of Wollongong, NSW, Australia; Illawarra Health and Medical Research Institute, University of Wollongong, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Medical Radiation Physics, University of Wollongong, NSW, Australia; Illawarra Health and Medical Research Institute, University of Wollongong, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author><author><name sortKey="Tehei, Moeava" sort="Tehei, Moeava" uniqKey="Tehei M" first="Moeava" last="Tehei">Moeava Tehei</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Medical Radiation Physics, University of Wollongong, NSW, Australia; Illawarra Health and Medical Research Institute, University of Wollongong, NSW, Australia; Centre for Medical and Molecular Bioscience, University of Wollongong, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Medical Radiation Physics, University of Wollongong, NSW, Australia; Illawarra Health and Medical Research Institute, University of Wollongong, NSW, Australia; Centre for Medical and Molecular Bioscience, University of Wollongong, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author><author><name sortKey="Rosenfeld, Anatoly" sort="Rosenfeld, Anatoly" uniqKey="Rosenfeld A" first="Anatoly" last="Rosenfeld">Anatoly Rosenfeld</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Medical Radiation Physics, University of Wollongong, NSW, Australia; Illawarra Health and Medical Research Institute, University of Wollongong, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Medical Radiation Physics, University of Wollongong, NSW, Australia; Illawarra Health and Medical Research Institute, University of Wollongong, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author></analytic><series><title level="j">Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)</title><idno type="eISSN">1724-191X</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cerium (chemistry)</term><term>Cerium (pharmacology)</term><term>Gold (chemistry)</term><term>Humans</term><term>Male</term><term>Metal Nanoparticles (chemistry)</term><term>Monte Carlo Method</term><term>Nanoparticles</term><term>Oxides (chemistry)</term><term>Oxides (pharmacology)</term><term>Prostatic Neoplasms (radiotherapy)</term><term>Proton Therapy (methods)</term><term>Radiation Dosage</term><term>Radiotherapy Dosage</term><term>Tantalum (chemistry)</term><term>Tantalum (pharmacology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Cérium ()</term><term>Cérium (pharmacologie)</term><term>Dose de radiation</term><term>Dosimétrie en radiothérapie</term><term>Humains</term><term>Mâle</term><term>Méthode de Monte-Carlo</term><term>Nanoparticules</term><term>Nanoparticules métalliques ()</term><term>Or ()</term><term>Oxydes ()</term><term>Oxydes (pharmacologie)</term><term>Protonthérapie ()</term><term>Tantale ()</term><term>Tantale (pharmacologie)</term><term>Tumeurs de la prostate (radiothérapie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Cerium</term><term>Gold</term><term>Oxides</term><term>Tantalum</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Cerium</term><term>Oxides</term><term>Tantalum</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Metal Nanoparticles</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Proton Therapy</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Cérium</term><term>Oxydes</term><term>Tantale</term></keywords><keywords scheme="MESH" qualifier="radiotherapy" xml:lang="en"><term>Prostatic Neoplasms</term></keywords><keywords scheme="MESH" qualifier="radiothérapie" xml:lang="fr"><term>Tumeurs de la prostate</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term><term>Male</term><term>Monte Carlo Method</term><term>Nanoparticles</term><term>Radiation Dosage</term><term>Radiotherapy Dosage</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Cérium</term><term>Dose de radiation</term><term>Dosimétrie en radiothérapie</term><term>Humains</term><term>Mâle</term><term>Méthode de Monte-Carlo</term><term>Nanoparticules</term><term>Nanoparticules métalliques</term><term>Or</term><term>Oxydes</term><term>Protonthérapie</term><term>Tantale</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Nanoparticles (NPs) have been shown to enhance X-ray radiotherapy and proton therapy of cancer. The effectiveness of radiation damage is enhanced in the presence of high atomic number (high-Z) NPs due to increased production of low energy, higher linear energy transfer (LET) secondary electrons when NPs are selectively internalized by tumour cells. This work quantifies the local dose enhancement produced by the high-Z ceramic oxide NPs Ta2O5 and CeO2, in the target tumour, for the first time in proton therapy, by means of Geant4 simulations. The dose enhancement produced by the ceramic oxides is compared against gold NPs. The energy deposition on a nanoscale around a single nanoparticle of 100nm diameter is investigated using the Geant4-DNA extension to model particle interactions in the water medium. Enhancement of energy deposition in nano-sized shells of water, local to the NP boundary, ranging between 14% and 27% was observed for proton energies of 5MeV and 50MeV, depending on the NP material. Enhancement of electron production and energy deposition can be correlated to the direct DNA damage mechanism if the NP is in close proximity to the nucleus.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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